Table: Duplication Summary

Summary of the phylogenetic analysis of gene families whose three or more members are residing on human MHC paralogon HSA 1/6/9/19
For each gene family the chromosomal location and topologies (in the Newick format) of those genes are given, which arose through duplications after the invertebrates vertebrates split and before the tetrapod-fish divergence. The percentage bootstrap support of the internal branches is given with each relevant topology.
  • a Represents that a gene family member is not residing on human MHC paralogon.
  • b Indicates that the gene family member is positioned on a different chromosome, i.e. KDM4D/KDM4E is on Hsa 11, PLOD2 and PLOD3 are on Hsa3 and Hsa7 respectfully.
  • c Depicts the sub family.
Family Name Hsa1/15a Hsa6 Hsa9/18 Hsa19 Topology
ARID ARID3Ba - ARID3C ARID3A ((15,19)9) 91,66
ATP6V1G ATP6V1G3 ATP6V1G2 ATP6V1G1 - ((9,6)1) 91
BRD BRDT BRD2 BRD3 BRD4 (((6,9)19)1) 74,91,88
CAMSAP CAMSAP2 - CAMSAP1 CAMSAP3 ((1,9)19) 78,89
CDKN2 CDKN2C - CDKN2A, CDKN2B CDKN2D ((9,19)1) 90
COLGALT c COLGALT2 - CERCAM COLGALT1 ((1,19)9) 98,96
CREB3 CREB3L4 - CREB3 CREB3L3 ((9,19)1) 52,97
DNM DNM3 - DNM1 DNM2 ((1,19)9) 67,100
FAM129 FAM129A - FAM129B FAM129C ((1,9)19) 72,84
FNBP FNBP1L - FNBP1 TRIP10 ((1,19)9) 95,91
FUBP FUBP1 - FUBP3 KHSRP ((1,19)9) 92,89
GADD45 GADD45A - GADD45G GADD45B ((1,19)9) 69,100
HDGFRP HDGFRP3a - PSIP1 HDGFRP2 ((9,19)15)
KANK KANK4 - KANK1 KANK2, KANK3 (((9,19)19)1) 72,98,100
KDM KDM4A - KDM4C KDM4B ((1,9)19)b 57,69
MAN1 MAN1C1, MAN1A2 MAN1A1 - - ((6,1)1) 91,92
NFI NFIA - NFIB NFIX NFIC ((9,19)(1,19)) 94,99,98
PALM PALMD - PALM2 PALM ((9,19)1) 63,100
PBX PBX1 PBX2 PBX3 - ((1,9)6) 72,71
PKN PKN2 - PKN3 PKN1 ((1,19)9) 90,99
PLOD c PLOD1 - - - ((3,1)7)b 51,99
PRRC2 PRRC2C PRRC2A PRRC2B - ((1,9)6) 100,100
PTBP PTBP2 - PTBP3 PTBP1 ((9,19)1) 93,100
RFX - - RFX3 RFX2 RFX1 ((19,9)19) 69,58
RNF RNF223 - RNF183 RNF225 ((9,19)1) 58
S1PR S1PR1 - S1PR3 S1PR2, S1PR5, S1PR4 (((9,1)(19,19)19)) 76,99,100
SH SHFa - SHB SHD ((9,19)15)
SH2D BCAR3 - SH2D3C SH2D3A ((1,19)9) 50,70
SH3GL SH3GL3a - SH3GL2 SH3GL1 ((9,19)15) 74,90
SHC SHC1, SHC4a - SHC3 SHC2 (((9,19)1)15) 96,59,56
SLC25A SLC25A24 - SLC25A25 SLC25A41 SLC25A23 (((9,19)19)1) 70
SLC44A SLC44A5 SLC44A4 - SLC44A2 ((1,19)6) 100,99
TNF FASLG TNF TNFSF15 TNFSF14 ((((6,6)9)1)19) 82,53
TPM TPM3, TPM1a - TPM2 TPM4 (((9,19)(1,15)) 50,100,57

Hsa: Homo Sapien Autosome.