Table: Families analysed for MHC paralogon

List of human gene families inhabiting Human Chromosomes 1/6/9/19 which were used in the phylogenetic analysis of MHC paralogon. Please click on particular family to view its members.

  MHC Paralogon Summary


  Paralogon:  
  Number of Families:  
40   

  Number of Family Members:  
176   

  Number of Sequences:  
2246   

Gene Family Name Years Number of Included Taxa Functions Number of Sequences Included
Mannosidases alpha class 1 (MAN1) 2016 26 Calcium ion binding,Mannosidase activity. 60
Cyclin-dependent kinase inhibitor 2 Family (CDKN2) 2016 19 Protein kinase binding,Protein binding,Cyclin-dependent protein serine/threonine kinase inhibitor activity. 38
Nuclear factor I family (NFI) 2016 24 Involved in positive regulation of transcription, Transcription factor binding, Double-stranded DNA binding. 50
KN motif and ankyrin repeat domain containing (KANK) 2016 23 Protein binding, Beta-catenin binding. 54
Solute carrier family 35 (SLC35) 2016 28 UDP-glucuronic acid transmembrane transporter activity, Nucleotide-sugar transmembrane transporter activity. 59
Growth arrest and DNA-damage-inducible 45 Family (GADD45) 2016 24 Core promoter binding, Protein binding. 60
Far upstream element (FUSE) binding protein family (FUBP) 2016 26 DNA binding, poly(A) RNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. 53
Transforming growth factor beta receptor family (TGFBR) 2016 23 Activin binding, Transforming growth factor beta receptor binding, Heparin binding, SMAD binding 33
PHD finger protein family (PHF) 2016 16 Zinc ion binding, Methylated histone binding, DNA binding. 37
Solute carrier family 25 (SLC25) 2016 29 Transmembrane transport, Cellular response to calcium ion. 104
Solute carrier family 27 (SLC27) 2016 29 Long-chain fatty acid transport, Bile acid metabolic process. 108
Src homology 2 domain containing adaptor protein (SH) 2016 27 Apoptotic process, Adaptor activity. 58
Regulatory factor X family (RFX) 2016 24 Regulation of transcription from RNA polymerase II promoter, DNA binding. 79
Procollagen-lysine,2-oxoglutarate 5-dioxygenase family (PLOD)/(COLGALT) 2016 27 Procollagen galactosyltransferase activity. 89
Sphingosine 1-phosphate receptors (S1PR1) 2016 21 Sphingosine-1-phosphate signaling pathway, Immune response. 64
Protein-kinase N family (PKN) 2016 26 Protein phosphorylation, Signal transduction. 60
Lysine demethylase 4 (KDM4) 2016 18 Histone demethylation, Chromatin organization, Regulation of transcription. 48
AT-rich interaction domain containing (ARID) 2016 23 Regulation of transcription from RNA polymerase II promoter, Chromatin remodeling. 58
pre-B-cell leukemia homeobox (PBX) 2016 25 Transcription factor binding. 42
Formin binding protein family (FNBP1) 2016 34 Identical protein binding, Lipid binding. 70
NSP adaptor proteins (SH2D3) 2016 26 Protein binding. 54
Paralemmins (PALM) 2016 16 Regulation of cell shape. 30
Syntaxin binding protein (STXBP) 2016 24 Syntaxin binding. 44
Proline-rich coiled-coil family (PRRC2) 2016 16 Protein C-terminus binding. 34
Family with sequence similarity 129 (FAM129)/(NIBAN) 2016 22 Protein binding. 44
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G (ATP6V1G) 2016 26 Hydrogen-exporting ATPase activity, phosphorylative mechanism. 40
Calmodulin regulated spectrin-associated protein family (CAMSAP) 2016 23 Protein binding. 63
Solute carrier family 44 (SLC44) 2016 26 Small molecule metabolic process. 61
Tumor necrosis factor superfamily (TNFSF) 2016 21 Tumor necrosis factor receptor binding. 51
Tropomyosins (TPM) 2016 22 Binds to actin filaments in muscle and non-muscle cells, Smooth muscle contraction is regulated by interaction with caldesmon, Non-muscle cells is implicated in stabilizing cytoskeleton actin filaments 42
Polypyrimidine tract binding protein family (PTBP) 2016 20 RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. Plays also a role in the regulation of translation. 44
CREB3 transcription factor family (CREB3) 2016 18 Plays a role in the unfolded protein response (upr), Cell proliferation and migration, Tumor suppression and inflammatory gene expression. 48
Regulators of G-protein signaling subfamily 2 (RGS) 2016 13 GTPase activator activity, Calmodulin binding, Beta-tubulin binding. 72
Dynamin family (DNM) 2016 23 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. Involved in receptor-mediated endocytosis. 67
SHC adaptor proteins (SHC) 2016 23 Signaling adapter that couples activated growth factor receptors to signaling pathways, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. 55
Chloride intracellular channels (CLIC) 2016 27 Form chloride ion channels. channel activity depends on the ph. Involved in regulation of the cell cycle. 69
SH3-domain GRB2-like endophilin family (SH3GL) 2016 20 Implicated in endocytosis and recruit other proteins to membranes with high curvature (by similarity). 67
Heparin binding growth factor family (HDGF) 2016 24 Heparin-binding protein, Mitogenic activity for fibroblasts, Transcriptional repressor. 51
Bromodomain and extra-terminal domain family (BRD) 2016 24 Plays a key role in spermatogenesis, Involved in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. 53
Ring finger protein subfamily 2 (RNF) 2016 18 Zinc ion binding. 33