Gene Family Table

List of human gene families used in the phylogenetic analysis. Please click on particular family to view its members.

  Database Summary

  Number of Paralogons covered:  
4   

  Number of Human Gene Families:  
221   

  Number of Human Gene Family Members:  
1247   

Gene Family Name Years Number of Included Taxa Functions Number of Sequences Included
Solute carrier family 4 (SLC4) 2007 9 Inorganic anion exchanger activity, Bicarbonate transport, Chloride transport. 37
Fibrillar collagens (COL) 2007 11 Extracellular matrix structural constituent, Structural constituent of bone, Phosphate transport, Cell adhesion, Skeletal development, Perception of sound. 40
Erb-b2 receptor tyrosine kinases (ERBB) 2007 9 Epidermal growth factor receptor activity, Protein serine/threonine kinase activity, Electron transporter activity, Cell proliferation, ATP binding. 29
GLI zinc-finger protein family (GLI) 2007 13 Regulation of transcription from RNA , polymerase II promoter, Morphogenesis of limb and brain. 29
Hedgehog signaling molecule family (HH) 2007 14 Mesodermal cell fate determination, Proteolysis and peptidolysis, Cell-cell signaling, Intein-mediated protein splicing. 32
Inhibin subunits (INH) 2007 15 Cytokine activity, Growth factor activity, Induction of apoptosis, Mesoderm development, Defense response. 39
Insulin like growth factor binding proteins (IGFBP) 2007 12 Regulation of cell growth, Signal transduction, Skeletal Development, Cell proliferation. 38
Integrin beta subunits (ITGB) 2007 8 Receptor activity, Cell-matrix adhesion, Integrinmediated Signaling pathway. 33
Myosin light chains (MYL) 2007 14 Phosphoprotein phosphatase activity, Structural constituent of muscle, Muscle development, Microfilament motor activity. 45
Sp transcription factors (SP) 2007 9 RNA polymerase II transcription factor activity. 36
Zinc finger protein subfamily 1A (ZNFN1A)/(IKZF) 2007 10 DNA-dependent regulation of transcription, Specification and the maturation of the lymphocyte. 30
ATP synthase, H+ transporting, mitochondrial F0 complex (ATP5G/ATP5MC) 2010 18 Lipid binding, Hydrogen ion transmembrane transporter activity, Transporter activity, Protein binding. 29
Calcium binding and coiled-coil domain (CALCOCO) 2010 21 Transcription coactivator activity, Protein binding, Protein homodimerization activity. 41
Chromobox family (CBX) 2010 14 Chromatin binding, Enzyme binding, DNA binding, Protein binding, Transcription repressor activity, Ubiquitin-protein ligase activity. 71
Heterogeneous nuclear ribonucleoprotein A (HNRNPA) 2010 16 Nucleotide binding, RNA binding, Protein binding. 37
Nuclear factor (erythroid-derived) (NFE) 2010 21 Transcription factor activity, Transcription coactivator activity, Protein N-terminus binding, Sequence-specific DNA binding, WW domain binding, Protein dimerization activity. 51
Oxysterol binding proteins (OSBP) 2010 21 Protein binding. 55
Phosphodiesterase 1 Calmodulin-dependent (PDE1) 2010 25 Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, Hydrolase activity, Calmodulin binding 46
Rho family GTPase (RND) 2010 18 GTP binding, GTPase activity, Nucleotide binding, Protein binding. 35
Secernin (SCRN) 2010 25 Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. 52
Sorting nexins subfamily 1 (SNX) 2010 10 Protein binding, Phosphoinositide binding, signal transducer activity, Receptor binding. 23
WAS/WASL interacting protein family (WIPF) 2010 15 Actin binding, Profilin binding. 31
Amiloride-sensitive cation channel neuronal (ACCN)/(ASIC) 2013 20 Ligand-gated sodium,Channel activity, Protein binding,Ion channel activity. 60
ATPase H+ transporting V0 Subunit A (ATP6V0A) 2013 23 Hydrogen ion transmembrane transporter activity, ATPase binding, Insulin receptor signaling pathway, ATP hydrolysis coupled proton transport. 74
Calcium voltage-gated channel auxiliary beta subunits (CACNB) 2013 14 Voltage-gated ion channel activity,High voltage-gated calcium channel activity, Protein binding. 46
Carbohydrate sulfotransferases (CHST) 2013 17 Sulfotransferase activity, Transferase activity, Cell adhesion. 84
CAP-GLY domain containing linker protein (CLIP) 2013 28 Nucleic acid binding, Protein homodimerization activity, Microtubule binding, Positive regulation of microtubule polymerization. 89
FKBP prolyl isomerases (FKBP) 2013 25 FK506 binding,Peptidyl-prolyl cis-trans isomerase activity,Calcium ion binding 104
Formin-like (FMNL) 2013 21 Actin binding, Profilin binding, Rho GTPase binding, Substrate-dependent cell migration. 50
Growth factor receptor-bound proteins (GRB) 2013 27 Protein binding, SH3/SH2 adaptor activity, Leukocyte migration, Epidermal growth factor receptor. 67
Histone deacetylases, class II (HDAC) 2013 17 Histone deacetylase binding, Potassium ion binding, Hydrolase activity, Activating transcription factor binding, Sequence-specific DNA binding. 61
Inhibitor of growth family (ING) 2013 18 Protein binding,Zinc ion binding, Metal ion binding, Histone acetyltransferase activity, Transcription coactivator activity. 70
Neurexophilins (NXPH) 2013 13 Protein binding, Receptor binding, Neuropeptide signaling pathway. 34
ORM1-like (ORMDL) 2013 15 Protein binding. 30
Pyruvate dehydrogenase kinase (PDK) 2013 20 Pyruvate dehydrogenase (acetyl-transferring) kinase activity, Two-component sensor activity, Protein heterodimerization activity, ATP binding. 67
Pleckstrin homology domain containing, family A (PLEKHA) 2013 26 Phospholipid binding,1-phosphatidylinositol binding, Glycolipid transporter activity, Glycolipid binding. 41
Protein phosphatase 1 regulatory 1 subunits (PPP1R1) 2013 18 Protein binding, Protein serine/threonine phosphatase inhibitor activity, Protein kinase inhibitor activity, Receptor binding. 38
Protein kinase gamma subunit (PRKAG) 2013 26 Protein binding, CAMP-dependent protein kinase activity, AMP binding, CAMP-dependent protein kinase regulator activity, Protein kinase binding, Phosphorylase kinase regulator activity. 63
Transmembrane protein 106 (TMEM106) 2013 24 "Putative transmembrane protein, molecular function unknown" 46
Tensin (TNS) 2013 25 Actin binding, Protein binding. 74
Vesicle-associated membrane protein (VAMP) 2013 15 Protein binding, Syntaxin binding, Phospholipid binding, Calmodulin binding. 59
Zinc finger protein 385 (ZNF385) 2013 17 Protein binding, Zinc ion binding, DNA binding, Metal ion binding, Nucleic acid binding. 51
ATP binding cassette subfamily A,G (ABCA, ABCG) 2014 18 ATPase activity, nucleotide binding, ATPase activity coupled to transmembr-ane movement of substances, ATP binding, Cholesterol absorption, transport. 142
Bromodomain containing (BRD)/(BAZ)/(BPTF)/(KAT)/(CERC) 2014 27 Zinc ion binding, DNA binding, Ubiquitin-protein ligase activity, Histone acetyltransferse activity, Transcription cofactor activity 136
Chaperonins (CCT) 2014 27 Unfolded protein binding, ATP binding, Catalytic activity, The complex folds various proteins including actin and tubulin. 171
Cyclin dependent kinases (CDK) 2014 28 Cyclin-dependent protein kinase activity, Transferase activity , Protein serine/threonine & tyrosine kinase activity, Signal transducer activity. 183
Beta-gamma crystallins (CRYB, CRYG) 2014 19 Structural constituent of eye lens, Visual perception. 110
G protein-coupled receptors, Class F frizzled (FZD) 2014 21 G-protein coupled receptor activity, Transmembrane receptor activity, Frizzled signaling pathway. 102
Integrin alpha subunits (ITGA) 2014 16 Protein binding, Cell-matrix adhesion, Integrin mediated signaling pathway, Integrin complex. 146
Potassium voltage-gated channel, subfamily H (KCNH)/(CNG) 2014 15 Calmodulin binding, Voltage-gated potassium channel activity, Signal transducer activity, Nucleotide binding, cGMP binding, Intracellular cAMP activated cation channel activity. 103
Potassium inwardly rectifying channel subfamily J (KCNJ) 2014 27 Amino acid-polyamine transporter activity, Sodium symporter activity, Oxygen transporter activity, Structural constituent of ribosome. 239
Methyltransferase (METTL) 2014 27 Methyltransferase. 56
MLX interacting protein (MLX) 2014 15 Transcription factor activity, Regulation of transcription, DNA dependent, Transcription. 28
Myosin heavy chains, class I (MYO1) 2014 28 ATP binding, ATPase activity, Calmodulin binding, Actin binding, Microfilament motor activity. 161
Nascent polypeptide associated complex subunit alpha & domain proteins (NACA) 2014 18 Protein biosynthesis, Nascent polypeptide association, Nascent polypeptide associated complex. 29
Neuronal differentiation (NEUROD)/Neurogenin (NEUROG) 2014 23 RNA polymerase II transcription factor activity, Double-stranded DNA binding, E-box binding. 89
Rap guanine nucleotide exchange factor (RAPGEF) 2014 27 Calcium ion binding, Signal transducer activity, Protein binding, Rap guanyl-nucleotide exchange factor activity, CAMP-dependent protein kinase regulator activity, cAMP binding. 95
Ring finger protein subfamily 1 (RNF) 2014 21 Ubiquitin-protein ligase activity, Peptidase activity, Zinc ion binding, Protein ubiquitinition, Proteolysis, Peptidolysis, Ubiquitin ligase complex. 114
Solute carrier family 38 (SLC38) 2014 28 Amino acid-polyamine transporter activity, Oxygen transporter activity, Structural constituent of ribosome. 128
Solute carrier family 5 (SLC5) 2014 28 Sodium-dependent multivitamin transporter activity, Biotin binding, Transporter activity, Symporter activity, Ion transport, Sodium ion transport. 126
Suppressors of cytokine signaling (SOCS) 2014 26 SH3/SH2 adaptor activity, Insulin-like growth factor receptor binding , Prolactin receptor binding, Protein kinase inhibitor activity. 150
Receptor (G protein-coupled) activity modifying protein (RAMP) 2013 18 Coreceptor activity, Protein transporter activity, Intracellular protein transport. 44
EYA transcriptional coactivator and phosphatases (EYA) 2011 19 Metal ion binding, Hydrolase activity, Protein tyrosine phosphatase activity, Protein binding, Chromatin binding 62
Src family tyrosine kinases subfamily B (SrcB) 2011 23 Nucleotide binding, ATP binding, Transferase activity, Protein tyrosine kinase activity, Protein binding 62
Lysosomal transmembrane protein (LAPTM) 2011 27 Transport, Protein binding 62
Matrilins (MATN) 2011 14 Extracellular matrix structural constituent, Protein binding 46
MYB family of transcription factor genes (MYB) 2011 18 Sequence-specific DNA binding transcription factor activity,DNA, Protein binding 55
Myc proto-oncogene protein (MYC) 2011 20 Sequence-specific DNA binding transcription factor activity, Protein binding 53
Potassium voltage-gated channel delayed-rectifier, subfamily S (KCNS) 2011 26 Voltage-gated ion channel activity, Protein binding, Potassium channel regulator and delayed-rectifier activity 60
Protein tyrosine phosphatases receptor type subfamily 1 (PTPR) 2011 17 Protein tyrosine phosphatase activity, Hydrolase activity, Receptor activity, Protein binding 59
Src family tyrosine kinases subfamily A (SrcA) 2011 21 Protein tyrosine kinase activity, ATP binding, Transferase activity, Nucleotide binding, Protein binding 67
Syndecans (SDC) 2011 14 Cytoskeletal protein binding, Glycoprotein binding, Protein C-terminus binding, PDZ domain binding 46
WNT1 inducible signaling pathway (WISP)/(CCN) 2011 25 Protein binding, Insulin-like growth factor binding, Growth factor activity 63
Actin Binding LIM protein (ABLIM)/(AJUBA)/(ZYX) 2015 11 Actin binding,Zinc ion binding,Metal ion binding,Protein binding 66
Acyl-CoA Synthetase Family (ACSL)/(ACSBG) 2015 23 Long-chain fatty acid-CoA ligase activity,ATP binding, Nucleotide binding ,Ligase activity 80
ADAM Metallopeptidase Domain (ADAM) 2015 18 Metalloendopeptidase activity, ion binding, Protein binding 123
ADAM Metallopeptidase with Thrombospondin Type 1 Motif (ADAMTS) 2015 16 Peptidase activity, Heparin binding, Metal ion binding 106
Adrenoceptor alpha (ADRA)/(HTR) 2015 21 Signal transducer activity, Receptor activity, Serotonin binding 120
Actin filament associated protein (AFAP1) 2015 28 Actin binding, SH2 and SH3 domain binding, Protein tyrosine kinase activator activity 71
Ankyrin (ANK) 2015 21 Protein binding, Structural constituent of cytoskeleton 74
Annexins (ANXA) 2015 18 Protein binding, Calcium ion binding, Phospholipase inhibitor activity, Single-stranded RNA and DNA binding 147
ArfGAP(Ankyrin Repeat and PH Domain) (ACAP)/(AGAP)/(ARAP)/(ASAP) 2015 14 ARF GTPase activator activity,Metal ion binding,Zinc ion binding,Protein binding 27
Calcium/calmodulin-dependent protein kinases (CAMK) 2015 11 ATP binding, Calmodulin-dependent protein kinase activity, Protein serine/threonine kinase activity, Nucleotide binding 98
Cyclins (CCN) 2015 21 Protein binding, Protein kinase activity 136
Collagen alpha (COL) 2015 11 Protein homodimerization activity, Structural molecule activity,Heparin binding,Extracellular matrix structural constituent,Extracellular matrix structural constituent 67
Cytoplasmic Polyadenylation Element Binding Protein (CPEB) 2015 18 Nucleotide binding, RNA binding, Protein binding 46
Dickkopf WNT Signaling Pathway Inhibitor (DKK) 2015 25 Protein binding,Growth factor activity,Signal transducer activity,Low-density lipoprotein particle receptor binding 49
Distal-less homeobox (DLX)/(BAR)/(MSX)/(NKX1) 2015 12 Sequence-specific DNA binding, transcription factor activity 127
DNAJ (HSP40) heat shock proteins (DNAJ) 2015 18 Unfolded protein binding, Heat shock protein binding 61
DOCK family Rho GEFs (DOCK) 2015 37 GTPase activator activity, GTP binding, Guanyl-nucleotide exchange factor activity, Protein binding 118
M38 metallopeptidases/Dihydropyrimidinase-like (DPYS) 2015 22 Protein binding, Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 75
Dual specificity phosphatase (DUSP)(MKP)/(SSH) 2015 18 Hydrolase activity, Protein binding, MAP kinase tyrosine/serine/threonine phosphatase activity, Actin binding 146
Early B-cell factor 1 (EBF) 2015 21 DNA binding,Metal ion binding 47
Early Growth Response (EGR) 2015 14 Sequence-specific DNA binding transcription factor activity 64
Eukaryotic Translation Initiation Factor 4E Binding Protein family (EIF4EBP) 2015 23 Protein Binding, Translation repressor activity 38
Elongation of very long fatty acids protein (ELOVL) 2015 19 Protein binding, Transferase activity 91
Family with sequence similarity 13 (FAM13) 2015 27 GTPase activator activity 73
Family with sequence similarity 53 (FAM53) 2015 30 Role in neural development 67
Fibroblast growth factor family (FGF) 2015 17 Protein tyrosine kinase activity,Type 1 fibroblast growth factor receptor binding,Type 2 fibroblast growth factor receptor binding,Growth factor activity 37
Fibroblast growth factor receptor (FGFR) 2015 28 Protein binding, Fibroblast growth factor binding 73
GDNF family receptor alpha (GFRA) 2015 23 Glial cell-derived neurotrophic factor receptor activity 63
G Protein-Coupled Receptor (GPR)/(ADGRA) 2015 27 G-protein coupled receptor activity,Receptor activity,Signal transducer activity 59
G Protein Regulated Inducer of Neurite Outgrowth (GPRIN) 2015 8 Phosphoprotein binding 20
Glutamate Receptor Ionotropic (GRI) 2015 21 Protein binding, PDZ domain binding, Ion channel activity, Glutamate receptor activity, Transporter activity 137
G protein-coupled receptor kinase (GRK/ADRBK)/(AKT)/(SGK)/(RPS6KB) 2015 14 G-protein coupled receptor kinase activity,Rhodopsin kinase activity,ATP binding,Nucleotide binding,Protein serine/threonine kinase activity 150
Heterogeneous nuclear ribonucleoprotein H (HNRNPH)/(RBM12)/(ESRP) 2015 27 Nucleotide binding, RNA binding 86
HtrA serine peptidase (HTRA) 2015 27 Peptidase activity,Insulin-like growth factor binding,Serine-type endopeptidase activity 74
Janus kinase and microtubule interacting protein (JAKMIP) 2015 29 Kinase binding, Microtubule binding 55
Kv Channel Interacting Protein (KCNIP) 2015 28 Voltage-gated ion channel activity, Calcium ion binding, Protein heterodimerization activity, Protein binding, Potassium channel regulator activity, Ion channel activity, ER retention sequence binding, Transcription corepressor activity, DNA binding 72
KLF transcription factors (KLF) 2015 9 Metal ion binding, DNA binding, Zinc ion binding, Sequence-specific DNA binding transcription factor activity 69
Leucine-rich, glioma inactivated (LGI) 2015 32 Catalytic activity, Receptor binding 99
Lysyl oxidase homolog (LOX) 2015 25 Protein binding, Copper ion binding 89
Leucine zipper tumor suppressor family (LZTS) 2015 23 Protein binding 72
Mitogen-activated protein kinases (MAPK) 2015 22 MAP kinase activity, Histone deacetylase binding , ATP and nucleotide binding 73
Membrane-associated ring-CH-type fingers (MARCH)/(MARCHF) 2015 18 MHC protein binding, Zinc ion binding, Ligase activity, Ubiquitin-protein ligase activity 52
MAX dimerization proteins (MXD) 2015 25 Protein binding, DNA binding 68
Myozenins (MYOZ) 2015 29 Protein Binding 68
N-deacetylase and N-sulfotransferase (NDST) 2015 23 Sulfotransferase activity,Deacetylase activity,Hydrolase activity,Transferase activity,[heparan sulfate]-glucosamine N-sulfotransferase activity 64
Solute carrier family 57, NIPA-like magnesium transporters (SLC57, NIPA) 2015 22 Magnesium ion transport 68
NK Homeobox (NKX)/(HMX)/(TLX) 2015 4 DNA binding, Sequence-specific DNA binding transcription factor activity, Protein binding, Transcription factor binding, Protein self-association 85
Nucleophosmins (NPM) 2015 22 ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors 53
Neuregulins (NRG) 2015 23 Protein tyrosine kinase activator activity, Growth factor activity, Transcription cofactor activity, Protein binding 50
Neuron-specific protein family (NSG) 2015 20 Clathrin light chain binding 45
I-set domain containing (PALLD)/(MYPN)/(MYOT)/(OBSL1) 2015 25 Muscle alpha-actinin binding, Protein binding, Actin binding, Nebulin binding, Muscle alpha-actinin binding, Structural constituent of muscle, Cytoskeletal adaptor activity 57
Phosphodiesterases (PDE)  2015 15 Nucleotide binding,Metal ion binding,Hydrolase activity,CGMP binding,3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity 91
PZD and LIM domain protein (PDLIM) 2015 37 Zinc ion binding, Protein binding 89
Pituitary homeobox (PITX) 2015 22 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 52
Polycystic Kidney Disease (PKD) 2015 26 Protein binding, Ion channel binding, Voltage-gated cation channel activity, Sour taste receptor activity 108
POU class (POU) 2015 13 RNA polymerase II activating transcription factor binding ,RNA polymerase II transcription coactivator activity 80
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator (PPARGC) 2015 24 Ligand-dependent nuclear receptor binding, Transcription coactivator activity, Protein binding 50
Protein phosphotase 2, regulatory subunit B (PPP2R2) 2015 16 Protein binding, Protein phosphatase type 2A regulator activity 52
Protein Phosphate 3 Catalytic Subunit (PPP3C) 2015 21 Calmodulin binding, Hydrolase activity, Phosphoprotein phosphatase activity, Drug binding, Enzyme binding, Protein heterodimerization activity 39
Pleckstrin and Sec7 domain containing (PSD) 2015 32 Signal transducer activity, ARF guanyl-nucleotide exchange factor activity 70
RNA Binding Motif (RBM) 2015 21 Nucleotide binding, RNA binding, Protein binding 80
Receptor accessory proteins (REEP) 2015 14 Protein binding, Receptor binding, Microtubule binding 63
Regulators of G-protein signaling subfamily 1 (RGS) 2015 18 GTPase activator activity, Protein binding, Signal transducer activity 95
Rho family GTPases (RHO) 2015 13 Rho GTPase binding,GTPase activity,Nucleotide binding,Protein binding,Kinase inhibitor activity,GTP binding,GBD domain binding 63
RUN and FYVE domain containing (RUF) 2015 27 Nervous system development,Cell differentiation,Multicellular organismal development,Protein binding, 93
SEC24 homologs (SEC24) 2015 34 Zinc ion binding, Vesicle-mediated transport, Cellular membrane organization 93
Septins (SEPTIN) 2015 23 Nucleotide binding, GTP binding, Protein binding 187
Solute Carrier Family 26 (SLC26) 2015 22 Transporter activity, Anion antiporter activity, Protein binding, Ion channel activity 131
Solute Carrier Family 39 (SLC39) 2015 19 Metal ion transmembrane transporter activity,Zinc ion transmembrane transporter activity 98
Slit guidance ligand (SLIT) 2015 33 Calcium ion binding, Roundabout binding, Protein binding 74
Synucleins (SNC) 2015 18 Alpha-tubulin binding, ion binding, Cysteine-type endopeptidase inhibitor activity involved in apoptotic process, Arachidonic acid binding, Fatty acid binding, Protein binding, Oxidoreductase activity, Phospholipase inhibitor activity 30
SPARC (osteonectin), cwcv and kazal like domains proteoglycan (SPOCK) 2015 26 Calcium ion binding, Extracellular matrix binding, Glycosaminoglycan binding 56
Serine/threonine kinase 32 (STK32) 2015 34 Protein serine/threonine kinase activity, Metal ion binding, ATP binding 71
Synaptopodins (SYNPO) 2015 15 Actin binding,Protein binding 36
TACC family (TACC) 2015 25 Cerebral cortex development, Protein domain specific binding, Interkinetic nuclear migration, Cell cycle 55
TCF/LEF transcription factor family (TCF) 2015 17 Chromatin binding,Transcription regulatory region DNA binding,Sequence-specific DNA binding ,transcription factor activity,Protein binding,Beta-catenin binding 50
Tetraspanins (TSPAN) 2015 16 Ubiquitin-protein ligase activity,Protein binding,Signal transducer activity 139
UNC-5 netrin receptors (UNC-5)/(BAI)/(ADGRB) 2015 17 Receptor activity, Netrin receptor activity, Protein binding 89
Voltage dependent anion channels (VDAC) 2015 22 Voltage-gated anion channel activity, Nucleotide binding, Porin activity 56
Sorbin and SH3 domain containing (SH3RF)/(SORBS) 2015 17 Protein binding, Zinc ion binding 57
Mannosidases alpha class 1 (MAN1) 2016 26 Calcium ion binding,Mannosidase activity. 60
Cyclin-dependent kinase inhibitor 2 Family (CDKN2) 2016 19 Protein kinase binding,Protein binding,Cyclin-dependent protein serine/threonine kinase inhibitor activity. 38
Nuclear factor I family (NFI) 2016 24 Involved in positive regulation of transcription, Transcription factor binding, Double-stranded DNA binding. 50
KN motif and ankyrin repeat domain containing (KANK) 2016 23 Protein binding, Beta-catenin binding. 54
Solute carrier family 35 (SLC35) 2016 28 UDP-glucuronic acid transmembrane transporter activity, Nucleotide-sugar transmembrane transporter activity. 59
Growth arrest and DNA-damage-inducible 45 Family (GADD45) 2016 24 Core promoter binding, Protein binding. 60
Far upstream element (FUSE) binding protein family (FUBP) 2016 26 DNA binding, poly(A) RNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. 53
Transforming growth factor beta receptor family (TGFBR) 2016 23 Activin binding, Transforming growth factor beta receptor binding, Heparin binding, SMAD binding 33
PHD finger protein family (PHF) 2016 16 Zinc ion binding, Methylated histone binding, DNA binding. 37
Solute carrier family 25 (SLC25) 2016 29 Transmembrane transport, Cellular response to calcium ion. 104
Solute carrier family 27 (SLC27) 2016 29 Long-chain fatty acid transport, Bile acid metabolic process. 108
Src homology 2 domain containing adaptor protein (SH) 2016 27 Apoptotic process, Adaptor activity. 58
Regulatory factor X family (RFX) 2016 24 Regulation of transcription from RNA polymerase II promoter, DNA binding. 79
Procollagen-lysine,2-oxoglutarate 5-dioxygenase family (PLOD)/(COLGALT) 2016 27 Procollagen galactosyltransferase activity. 89
Sphingosine 1-phosphate receptors (S1PR1) 2016 21 Sphingosine-1-phosphate signaling pathway, Immune response. 64
Protein-kinase N family (PKN) 2016 26 Protein phosphorylation, Signal transduction. 60
Lysine demethylase 4 (KDM4) 2016 18 Histone demethylation, Chromatin organization, Regulation of transcription. 48
AT-rich interaction domain containing (ARID) 2016 23 Regulation of transcription from RNA polymerase II promoter, Chromatin remodeling. 58
pre-B-cell leukemia homeobox (PBX) 2016 25 Transcription factor binding. 42
Formin binding protein family (FNBP1) 2016 34 Identical protein binding, Lipid binding. 70
NSP adaptor proteins (SH2D3) 2016 26 Protein binding. 54
Paralemmins (PALM) 2016 16 Regulation of cell shape. 30
Syntaxin binding protein (STXBP) 2016 24 Syntaxin binding. 44
Proline-rich coiled-coil family (PRRC2) 2016 16 Protein C-terminus binding. 34
Family with sequence similarity 129 (FAM129)/(NIBAN) 2016 22 Protein binding. 44
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G (ATP6V1G) 2016 26 Hydrogen-exporting ATPase activity, phosphorylative mechanism. 40
Calmodulin regulated spectrin-associated protein family (CAMSAP) 2016 23 Protein binding. 63
Solute carrier family 44 (SLC44) 2016 26 Small molecule metabolic process. 61
Tumor necrosis factor superfamily (TNFSF) 2016 21 Tumor necrosis factor receptor binding. 51
Tropomyosins (TPM) 2016 22 Binds to actin filaments in muscle and non-muscle cells, Smooth muscle contraction is regulated by interaction with caldesmon, Non-muscle cells is implicated in stabilizing cytoskeleton actin filaments 42
Polypyrimidine tract binding protein family (PTBP) 2016 20 RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. Plays also a role in the regulation of translation. 44
CREB3 transcription factor family (CREB3) 2016 18 Plays a role in the unfolded protein response (upr), Cell proliferation and migration, Tumor suppression and inflammatory gene expression. 48
Regulators of G-protein signaling subfamily 2 (RGS) 2016 13 GTPase activator activity, Calmodulin binding, Beta-tubulin binding. 72
Dynamin family (DNM) 2016 23 Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. Involved in receptor-mediated endocytosis. 67
SHC adaptor proteins (SHC) 2016 23 Signaling adapter that couples activated growth factor receptors to signaling pathways, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. 55
Chloride intracellular channels (CLIC) 2016 27 Form chloride ion channels. channel activity depends on the ph. Involved in regulation of the cell cycle. 69
SH3-domain GRB2-like endophilin family (SH3GL) 2016 20 Implicated in endocytosis and recruit other proteins to membranes with high curvature (by similarity). 67
Heparin binding growth factor family (HDGF) 2016 24 Heparin-binding protein, Mitogenic activity for fibroblasts, Transcriptional repressor. 51
Bromodomain and extra-terminal domain family (BRD) 2016 24 Plays a key role in spermatogenesis, Involved in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. 53
Ring finger protein subfamily 2 (RNF) 2016 18 Zinc ion binding. 33
DLG associated proteins (DLGAP) 2017 25 Protein binding activity 85
E2F transcription factors (E2F) 2017 31 DNA binding, Protein binding, Sequence-specific DNA binding transcription factor activity, Transcription factor binding 84
Family with Sequence Similarity 110 (FAM110) 2017 25 Alpha-tubulin binding,Protein binding 56
Grainyhead like Transcription factor (GRHL)/(TFCP2) 2017 26 Chromatin DNA binding, Sequence-specific DNA binding, Protein binding. 57
Inhibitor of DNA binding proteins (ID) 2017 35 Sequence-specific DNA binding transcription factor activity, Protein binding, Protein dimerization activity 65
Maestro heat-like repeat-containing (MROH) 2017 22 Protein binding 46
Zinc fingers C2H2C-type (MYT) 2017 22 Zinc ion binding,Sequence-specific DNA binding transcription factor activity 48
Nuclear Receptor Coactivator (NCOA) 2017 22 Protein dimerization activity,Chromatin binding,Nuclear hormone receptor binding,RNA polymerase II regulatory region DNA binding 54
Na+/K+ transporting ATPase interacting (NKAIN) 2017 24 Involves in ATPase binding 46
Potassium Voltage-Gated Channel subfamily Q (KCNQ) 2017 28 Voltage-gated potassium channel activity,Ankyrin binding,Delayed rectifier potassium channel activity 67
Regulators of G-protein signaling subfamily 3 (RGS) 2017 31 GTPase activator activity,Calmodulin binding,Protein binding 101
Regulating synaptic membrane exocytosis family (RIMS) 2017 27 Ion channel binding,Protein heterodimerization activity,Rab GTPase binding 49
R-spondin family (RSPO) 2017 31 Heparin binding, G-protein coupled receptor binding, Protein binding, Receptor binding 60
Solute carrier family 30 (SLC30) 2017 23 Zinc ion transmembrane transporter activity, Protein binding, Cation transmembrane transporter activity 74
Syntrophins (SNT) 2017 28 Actin binding, PDZ domain binding, Calmodulin binding, 81
Sorting nexins subfamily 2 (SNX) 2017 29 Protein binding,Phosphatidylinositol binding 43
Stathmins (STMN) 2017 22 Tubulin binding,Protein domain specific binding,Signal transducer activity 63
Serine/Threonine-Protein Kinases (STK) 2017 25 ATP binding, Protein homodimerization activity, Protein serine/threonine kinase activity,Protein binding 72
Transcription Elongation factor A (SII) Proteins (TCEA) 2017 22 Zinc ion binding,DNA binding,Protein binding 51
UBX domain containing (UBXN) 2017 22 Ubiquitin binding,Protein phosphatase type 1 regulator activity,Protein binding 25
XK related family (XKR) 2017 24 Promotes phosphatidylserine exposure on apoptotic cell surface 101
YTH domain containing N6-methyladenosine readers subfamily F (YTHF) 2017 24 Poly(A) RNA binding, N6-methyladenosine-containing RNA binding 50
WDR domain (WDR) 2019 36 Cerebral cortical development, neuronal proliferation and migration 57
HR lysine demethylase and nuclear receptor corepressor (HR)/(KDM3) 2015 16 Transcription regulator controlling hair biology, neutral activity and cell cycle. 45
Antizyme Inhibitor (AZIN)/(ODC) 2017 25 Protein binding, Ornithine decarboxylase activator activity 55
Cholinergic receptors nicotinic subunits (CHRN) 2017 32 Drug binding,Ion channel activity,Acetylcholine receptor activity 123
Ciliary Rootlet Coiled-Coil Proteins (CROCC) 2017 28 Protein binding activity 42
Nuclear Receptor Binding SET domain protein (NSD) 2015 32 Chromatin binding, Methyltransferase activity, Transcription regulator activator activity, Metal ion binding. 79