Table: Duplication Summary

Summary of the phylogenetic analysis of gene families whose three or more members are residing on FGFR paralogon HSA 4/5/8/10

For each gene family the chromosomal location and topologies (in the Newick format) of those genes are given, which arose through duplications after the invertebrates vertebrates split and before the tetrapod-fish divergence. The percentage bootstrap support of the internal branches is given with each relevant topology.

• a, b, c Indicates that the gene family members are positioned on Hsa 2, Hsa 20 and Hsa 11 respectively.

Family Name	Hsa4/2a	Hsa5	Hsa8/20b	Hsa10/11c	Consistency_with_FGFR_Phylogeny	Topology
ANK	ANK2	-	ANK1	ANK3	-	((4,10) 8) 100,96
DPYSL	CRMP1	DPYSL3	DPYSL2	DPYSL4	-	(((8, 10) 5) 4) 91,69,100
FAM13	FAM13A	FAM13B	-	FAM13C	-	((4, 5) 10) 91
FAM53	FAM53A	FAM53C	-	FAM53B	-	((4, 10) 5) 96,69
GFRA	-	GFRA3	GFRA2 GFRA4b	GFRA1	-	(((8, 10) 20) 5)b 95,92,100
JAKMIP	JAKMIP1	JAKMIP2	-	JAKMIP3	-	((4, 5) 10) 97,100
LGI	LGI2	-	LGI3	LGI1	-	((4, 10) 8) 77,98
LOXL	LOXL3a	-	LOXL2	LOXL4	-	((2, 10) 8) 60,99
NSG	NSG1	NSG2	-	CALY	-	((4, 5) 10) 99,50
PPP2R2	PPP2R2C	PPP2R2B	PPP2R2A	PPP2R2D	Yes	((4, 5)(8, 10)) 86,71,99
PITX	PITX2	PITX1	-	PITX3	-	((4, 5) 10) 75
PDLIM	PDLIM3	PDLIM4	-	PDLIM1	-	((5, 10) 4) 50,81
REEP	REEP1a	REEP2	REEP4	REEP3	Yes	((2, 5)(8, 10)) 93
SORBSc	SORBS2	-	SORBS3	SORBS1	-	((8, 10) 4) 67,56
SH3RFc	SH3RF1 SH3RF3a	SH3RF2	-	-	-	((4, 2) 5) 99
ABLIM	ABLIM2	ABLIM3	DMTN	ABLIM1	-	((5,10)4) 57,83
ACSL	ACSL1	ACSL6	-	ACSL5	-	((4,5)10) 99,99
ADAM	-	ADAM19	ADAM33b	ADAM12	-	((5,20)10) 54,79
ADAMTS	ADAMTS3	ADAMTS2	-	ADAMTS14	-	((4,5)10) 54,99
ADRA1A	ADRA2C ADRA2Ba	-	-	ADRA2A	-	((4,2)10) 69,100
ARAP	ARAP2	ARAP3	ASAP1	ARAP1c	-	((4,5)11) 50,99
ANXA	ANXA5	ANXA6	-	ANXA8	-	((4,5)10) 92,62
COLA1	COL25A1	COL23A1	COL22A1	COL13A1	-	((5,10)4) 91
DKK	DKK2	-	DKK4	DKK1	-	((4,10)8) 83
DNAJ	DNAJB14	DNAJC18	-	DNAJB12	-	((4,10)5)56,60
DOCK	-	DOCK2	DOCK5	DOCK1	-	((8,10)5)91,91
EBF	-	EBF1	EBF2	EBF3	-	((5,10)8) 99,93
EGR	-	EGR1	EGR3	EGR2	-	((8,10)5)62,99
FGF	-	FGF18	FGF17	FGF8	-	((8,10)5) 99,100
GPR	GPR125	-	GPR124	GPR123	-	((4,10)8) 74,99
GPRIN	GPRIN3	GPRIN1	-	GPRIN2	-	((5,10)4) 90
GRK	GRK4	GRK6	-	GRK5	-	((4,10)5) 84,71
HTRA	HTRA3	-	HTRA4	HTRA1	-	((8,10)4) 80,89
KCNIP	KCNIP4 KCNIP3a	KCNIP1	-	KCNIP2	-	(((5,4)10)2) 60
MAPK	MAPK10	MAPK9	-	MAPK8	-	((4,10)5)80,97
MYOZ	MYOZ2	MYOZ3	-	MYOZ1	-	((4,5)10) 79,100
NKX	-	NKX2-5	NKX2-6	NKX2-3	-	((8,10)5)
NPM	-	NPM1	NPM2	NPM3	-	((8,10)5)95
PDE	PDE6B	PDE6A	-	PDE6C	-	((4,5)10) 99,100
PPP3C	PPP3CA	-	PPP3CC	PPP3CB	-	((8,10)4) 95,76
PSD	PSD4a	PSD2	PSD3	PSD	-	(((8,5)10)2) 56,62,99
RUFY	RUFY3	RUFY1	-	RUFY2	-	((5,10)4) 98
SLIT	SLIT2	SLIT3	-	SLIT1	-	((4,5)10) 100,100
SNC	SNCA	SNCB	-	SNCG	-	((4,5)10) 69
SPOCK	SPOCK3	SPOCK1	-	SPOCK2	-	((4,5)10)99
SYNPO	SYNPO2	SYNPO	-	SYNPO2L	-	((4,10)5) 91
TCF7	LEF1	TCF7	-	TCF7L2	Yes	((4,5)(2,10)) 53,80,99
UNC5	UNC5C	UNC5A	UNC5D	UNC5B	-	(((4,5)10)8) 61,89