Human genome is littered with paralogy blocks consisting large syntenic regions with duplicated/triplicated/quadruplicated distribution in multiple distinct locations. For instance the popular paralogy blocks such as the HOX-cluster bearing homo sapiens autosomes (Hsa) 2/7/12/17, human FGFR-bearing paralogon (Hsa 4/5/8/10), MHC paralogon (Hsa 1/6/9/19) and Hsa 1/2/8/20 are investigated intensively over the past couple of decades to understand mechanisms that have shaped the current architecture of human genome. Some argued that such triplicated/quadruplicated human paralogy blocks are evidence of ancient polyploidy events in vertebrate history, whereas others have taken them as a consequence of small scale segmental/independant gene duplications and translocation events.
The current database focuses upon the history of subset of paralogy blocks residing on Hsa 2/7/12/17, Hsa 4/5/8/10, Hsa 1/2/8/20 and Hsa 1/6/9/19. Phylogenomic analysis of our data will provide the user to hunt knowledge about history of evolution of multigene families residing these paralogy blocks. Following features of database make it an interactive and comprehensive platform for phylogenomic understanding of human paralogy blocks.
Evolutionary Biologists, Geneticists, Biochemists, Biotechnologists, Bioinformaticians and researchers from versatile biological communities can utilize distinct features of this database to obtain evolutionary histories of human genes of their interest/human multigene families/human paralogy blocks in an interactive graphical manner.
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