Table: Families analysed for FGFR paralogon

List of human gene families inhabiting Human Chromosomes 4/5/8/10 which were used in the phylogenetic analysis of FGFR paralogon. Please click on particular family to view its members.

  FGFR Paralogon Summary

  Paralogon:  
Hsa: 4/5/8/10   

  Number of Families:  
82   

  Number of Family Members:  
546   

  Number of Family Sequences:  
6276   

Gene Family Name Years Number of Included Taxa Functions Number of Sequences Included
Actin Binding LIM protein (ABLIM)/(AJUBA)/(ZYX) 2015 11 Actin binding,Zinc ion binding,Metal ion binding,Protein binding 66
Acyl-CoA Synthetase Family (ACSL)/(ACSBG) 2015 23 Long-chain fatty acid-CoA ligase activity,ATP binding, Nucleotide binding ,Ligase activity 80
ADAM Metallopeptidase Domain (ADAM) 2015 18 Metalloendopeptidase activity, ion binding, Protein binding 123
ADAM Metallopeptidase with Thrombospondin Type 1 Motif (ADAMTS) 2015 16 Peptidase activity, Heparin binding, Metal ion binding 106
Adrenoceptor alpha (ADRA)/(HTR) 2015 21 Signal transducer activity, Receptor activity, Serotonin binding 120
Actin filament associated protein (AFAP1) 2015 28 Actin binding, SH2 and SH3 domain binding, Protein tyrosine kinase activator activity 71
Ankyrin (ANK) 2015 21 Protein binding, Structural constituent of cytoskeleton 74
Annexins (ANXA) 2015 18 Protein binding, Calcium ion binding, Phospholipase inhibitor activity, Single-stranded RNA and DNA binding 147
ArfGAP(Ankyrin Repeat and PH Domain) (ACAP)/(AGAP)/(ARAP)/(ASAP) 2015 14 ARF GTPase activator activity,Metal ion binding,Zinc ion binding,Protein binding 27
Calcium/calmodulin-dependent protein kinases (CAMK) 2015 11 ATP binding, Calmodulin-dependent protein kinase activity, Protein serine/threonine kinase activity, Nucleotide binding 98
Cyclins (CCN) 2015 21 Protein binding, Protein kinase activity 136
Collagen alpha (COL) 2015 11 Protein homodimerization activity, Structural molecule activity,Heparin binding,Extracellular matrix structural constituent,Extracellular matrix structural constituent 67
Cytoplasmic Polyadenylation Element Binding Protein (CPEB) 2015 18 Nucleotide binding, RNA binding, Protein binding 46
Dickkopf WNT Signaling Pathway Inhibitor (DKK) 2015 25 Protein binding,Growth factor activity,Signal transducer activity,Low-density lipoprotein particle receptor binding 49
Distal-less homeobox (DLX)/(BAR)/(MSX)/(NKX1) 2015 12 Sequence-specific DNA binding, transcription factor activity 127
DNAJ (HSP40) heat shock proteins (DNAJ) 2015 18 Unfolded protein binding, Heat shock protein binding 61
DOCK family Rho GEFs (DOCK) 2015 37 GTPase activator activity, GTP binding, Guanyl-nucleotide exchange factor activity, Protein binding 118
M38 metallopeptidases/Dihydropyrimidinase-like (DPYS) 2015 22 Protein binding, Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides 75
Dual specificity phosphatase (DUSP)(MKP)/(SSH) 2015 18 Hydrolase activity, Protein binding, MAP kinase tyrosine/serine/threonine phosphatase activity, Actin binding 146
Early B-cell factor 1 (EBF) 2015 21 DNA binding,Metal ion binding 47
Early Growth Response (EGR) 2015 14 Sequence-specific DNA binding transcription factor activity 64
Eukaryotic Translation Initiation Factor 4E Binding Protein family (EIF4EBP) 2015 23 Protein Binding, Translation repressor activity 38
Elongation of very long fatty acids protein (ELOVL) 2015 19 Protein binding, Transferase activity 91
Family with sequence similarity 13 (FAM13) 2015 27 GTPase activator activity 73
Family with sequence similarity 53 (FAM53) 2015 30 Role in neural development 67
Fibroblast growth factor family (FGF) 2015 17 Protein tyrosine kinase activity,Type 1 fibroblast growth factor receptor binding,Type 2 fibroblast growth factor receptor binding,Growth factor activity 37
Fibroblast growth factor receptor (FGFR) 2015 28 Protein binding, Fibroblast growth factor binding 73
GDNF family receptor alpha (GFRA) 2015 23 Glial cell-derived neurotrophic factor receptor activity 63
G Protein-Coupled Receptor (GPR)/(ADGRA) 2015 27 G-protein coupled receptor activity,Receptor activity,Signal transducer activity 59
G Protein Regulated Inducer of Neurite Outgrowth (GPRIN) 2015 8 Phosphoprotein binding 20
Glutamate Receptor Ionotropic (GRI) 2015 21 Protein binding, PDZ domain binding, Ion channel activity, Glutamate receptor activity, Transporter activity 137
G protein-coupled receptor kinase (GRK/ADRBK)/(AKT)/(SGK)/(RPS6KB) 2015 14 G-protein coupled receptor kinase activity,Rhodopsin kinase activity,ATP binding,Nucleotide binding,Protein serine/threonine kinase activity 150
Heterogeneous nuclear ribonucleoprotein H (HNRNPH)/(RBM12)/(ESRP) 2015 27 Nucleotide binding, RNA binding 86
HtrA serine peptidase (HTRA) 2015 27 Peptidase activity,Insulin-like growth factor binding,Serine-type endopeptidase activity 74
Janus kinase and microtubule interacting protein (JAKMIP) 2015 29 Kinase binding, Microtubule binding 55
Kv Channel Interacting Protein (KCNIP) 2015 28 Voltage-gated ion channel activity, Calcium ion binding, Protein heterodimerization activity, Protein binding, Potassium channel regulator activity, Ion channel activity, ER retention sequence binding, Transcription corepressor activity, DNA binding 72
KLF transcription factors (KLF) 2015 9 Metal ion binding, DNA binding, Zinc ion binding, Sequence-specific DNA binding transcription factor activity 69
Leucine-rich, glioma inactivated (LGI) 2015 32 Catalytic activity, Receptor binding 99
Lysyl oxidase homolog (LOX) 2015 25 Protein binding, Copper ion binding 89
Leucine zipper tumor suppressor family (LZTS) 2015 23 Protein binding 72
Mitogen-activated protein kinases (MAPK) 2015 22 MAP kinase activity, Histone deacetylase binding , ATP and nucleotide binding 73
Membrane-associated ring-CH-type fingers (MARCH)/(MARCHF) 2015 18 MHC protein binding, Zinc ion binding, Ligase activity, Ubiquitin-protein ligase activity 52
MAX dimerization proteins (MXD) 2015 25 Protein binding, DNA binding 68
Myozenins (MYOZ) 2015 29 Protein Binding 68
N-deacetylase and N-sulfotransferase (NDST) 2015 23 Sulfotransferase activity,Deacetylase activity,Hydrolase activity,Transferase activity,[heparan sulfate]-glucosamine N-sulfotransferase activity 64
Solute carrier family 57, NIPA-like magnesium transporters (SLC57, NIPA) 2015 22 Magnesium ion transport 68
NK Homeobox (NKX)/(HMX)/(TLX) 2015 4 DNA binding, Sequence-specific DNA binding transcription factor activity, Protein binding, Transcription factor binding, Protein self-association 85
Nucleophosmins (NPM) 2015 22 ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors 53
Neuregulins (NRG) 2015 23 Protein tyrosine kinase activator activity, Growth factor activity, Transcription cofactor activity, Protein binding 50
Neuron-specific protein family (NSG) 2015 20 Clathrin light chain binding 45
I-set domain containing (PALLD)/(MYPN)/(MYOT)/(OBSL1) 2015 25 Muscle alpha-actinin binding, Protein binding, Actin binding, Nebulin binding, Muscle alpha-actinin binding, Structural constituent of muscle, Cytoskeletal adaptor activity 57
Phosphodiesterases (PDE)  2015 15 Nucleotide binding,Metal ion binding,Hydrolase activity,CGMP binding,3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity 91
PZD and LIM domain protein (PDLIM) 2015 37 Zinc ion binding, Protein binding 89
Pituitary homeobox (PITX) 2015 22 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription 52
Polycystic Kidney Disease (PKD) 2015 26 Protein binding, Ion channel binding, Voltage-gated cation channel activity, Sour taste receptor activity 108
POU class (POU) 2015 13 RNA polymerase II activating transcription factor binding ,RNA polymerase II transcription coactivator activity 80
Peroxisome Proliferator-Activated Receptor Gamma, Coactivator (PPARGC) 2015 24 Ligand-dependent nuclear receptor binding, Transcription coactivator activity, Protein binding 50
Protein phosphotase 2, regulatory subunit B (PPP2R2) 2015 16 Protein binding, Protein phosphatase type 2A regulator activity 52
Protein Phosphate 3 Catalytic Subunit (PPP3C) 2015 21 Calmodulin binding, Hydrolase activity, Phosphoprotein phosphatase activity, Drug binding, Enzyme binding, Protein heterodimerization activity 39
Pleckstrin and Sec7 domain containing (PSD) 2015 32 Signal transducer activity, ARF guanyl-nucleotide exchange factor activity 70
RNA Binding Motif (RBM) 2015 21 Nucleotide binding, RNA binding, Protein binding 80
Receptor accessory proteins (REEP) 2015 14 Protein binding, Receptor binding, Microtubule binding 63
Regulators of G-protein signaling subfamily 1 (RGS) 2015 18 GTPase activator activity, Protein binding, Signal transducer activity 95
Rho family GTPases (RHO) 2015 13 Rho GTPase binding,GTPase activity,Nucleotide binding,Protein binding,Kinase inhibitor activity,GTP binding,GBD domain binding 63
RUN and FYVE domain containing (RUF) 2015 27 Nervous system development,Cell differentiation,Multicellular organismal development,Protein binding, 93
SEC24 homologs (SEC24) 2015 34 Zinc ion binding, Vesicle-mediated transport, Cellular membrane organization 93
Septins (SEPTIN) 2015 23 Nucleotide binding, GTP binding, Protein binding 187
Solute Carrier Family 26 (SLC26) 2015 22 Transporter activity, Anion antiporter activity, Protein binding, Ion channel activity 131
Solute Carrier Family 39 (SLC39) 2015 19 Metal ion transmembrane transporter activity,Zinc ion transmembrane transporter activity 98
Slit guidance ligand (SLIT) 2015 33 Calcium ion binding, Roundabout binding, Protein binding 74
Synucleins (SNC) 2015 18 Alpha-tubulin binding, ion binding, Cysteine-type endopeptidase inhibitor activity involved in apoptotic process, Arachidonic acid binding, Fatty acid binding, Protein binding, Oxidoreductase activity, Phospholipase inhibitor activity 30
SPARC (osteonectin), cwcv and kazal like domains proteoglycan (SPOCK) 2015 26 Calcium ion binding, Extracellular matrix binding, Glycosaminoglycan binding 56
Serine/threonine kinase 32 (STK32) 2015 34 Protein serine/threonine kinase activity, Metal ion binding, ATP binding 71
Synaptopodins (SYNPO) 2015 15 Actin binding,Protein binding 36
TACC family (TACC) 2015 25 Cerebral cortex development, Protein domain specific binding, Interkinetic nuclear migration, Cell cycle 55
TCF/LEF transcription factor family (TCF) 2015 17 Chromatin binding,Transcription regulatory region DNA binding,Sequence-specific DNA binding ,transcription factor activity,Protein binding,Beta-catenin binding 50
Tetraspanins (TSPAN) 2015 16 Ubiquitin-protein ligase activity,Protein binding,Signal transducer activity 139
UNC-5 netrin receptors (UNC-5)/(BAI)/(ADGRB) 2015 17 Receptor activity, Netrin receptor activity, Protein binding 89
Voltage dependent anion channels (VDAC) 2015 22 Voltage-gated anion channel activity, Nucleotide binding, Porin activity 56
Sorbin and SH3 domain containing (SH3RF)/(SORBS) 2015 17 Protein binding, Zinc ion binding 57
HR lysine demethylase and nuclear receptor corepressor (HR)/(KDM3) 2015 16 Transcription regulator controlling hair biology, neutral activity and cell cycle. 45
Nuclear Receptor Binding SET domain protein (NSD) 2015 32 Chromatin binding, Methyltransferase activity, Transcription regulator activator activity, Metal ion binding. 79
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