The PAHG database (Phylogenomic Analysis of the Human Genome) offers insights into the evolutionary history of human multigene families and paralogous regions.
This project is funded by Higher Education Commission of Pakistan.
The phylogenomic analysis of 1247 gene members of 221 gene families residing 58 families on four-fold and 163 on three-fold representation paralogy blocks which was conducted, and results were incorporated in the database. Present database deals with evolutionary history of 5% of human protein coding genes and our aim is to keep moving in this domain to cover phylogenetic history of all possible human protein coding gene families. We are also building a library which will work in R so that a user can access data by using an R interpretor. To increase the efficiency of database operations, dynamicity would be integrated into the graphical images. This database will help out Evolutionary Biologists, Geneticists, Biochemists, Biotechnologists, Bioinformaticians and researchers from versatile biological communities to obtain evolutionary histories of human genes of their interest/human multigene families/human paralogy blocks in an interactive graphical manner.
Data, sequences, and other information at this site are accessible for the public. However, they are not guaranteed to be accurate as this is an ongoing research. Data will be updated from time to time. When using data obtained from this website, it is important to cite the original publications and contributors of that data and the database. Please see "Citing the database" section below.
If a specific page of the database has been used, we would be pleased if you cite us in your article. Please use the following format:
Azhar, R., Arif, R., Khokhar, M.W., Rana, N., Abbasi, A.A.,* PAHG. http://pahg.qau.edu.pk/ (Unpublished)
Batool, F., Pervaiz, N., Khalid, Q., & Abbasi, A.A. Evolution of Human Multigene Families. Encyclopedia of Life Sciences. *Corresponding author
Nawaz, S.M., Asghar, R., Pervaiz, N., Ali, S., Hussain, I., Xing, P., Bao, Y., & Abbasi, A.A. Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders. BMC Ecology and Evolution. *Corresponding author
Pervaiz, N., Shakeel, N., Qasim, A., Zehra, R., Anwar, S., Rana, N., Xue,Y., Zhang, Z., Bao,Y., & Abbasi, A.A. Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals. BMC Evolutionary Biology. *Corresponding author
Seemab, S., Pervaiz, N., Zehra, R., Anwar, S.,Yiming Bao & Abbasi, A.A. Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene. BMC Evolutionary Biology *Corresponding author
Ma, L., Cao, J., Liu, L., Li, Z., Shireen, H., Pervaiz, N., Batool, F., Raza, R. Z., Zou, D., Bao, Y., Abbasi, A. A., & Zhang, Z. (2019). Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook. Current Protocols in Bioinformatics.
Wang, G., Yin, H., Li, B., Abbasi, A.A., … & Zhang, Z. (2019). Characterization and identification of long non-coding RNAs based on feature relationship. Bioinformatics.
Zhang, Z., Zhao, W., Xiao, J., Bao, Y., Wang, F., Abbasi, A.A*., ... & Tang, B. Database. Database Resources of the BIG Data Center in 2019. BIG Data Center Members.
Rabail Zehra, Amir Ali Abbasi (2018). Homo sapiens-Specific Binding Site Variants within Brain Exclusive Enhancers Are Subject to Accelerated Divergence across Human Population. Genome Biology and Evolution, 10 (3), 956-966. *Corresponding author
Naz, R., Tahir, S., Abbasi, A.A., (2017). An insight into the evolutionary history of human MHC paralogon. Molecular Phylogenetics and Evolution. *Corresponding author
Hafeez, M., Shabbir, M., Altaf, F., and Abbasi, A.A*. (2016). Phylogenomic analysis reveals ancient segmental duplications in the human genome. Molecular Phylogenetics and Evolution. 94: 95-100. *Corresponding Author
Ajmal, W., Khan, H., Abbasi, A.A*., (2014). Phylogenetic investigation of human FGFR-bearing paralogons favors piecemeal duplication theory of vertebrate genome evolution. Molecular Phylogenetics and Evolution. 81: 49-60. *Corresponding Author
Ambreen S , Khalil F , Abbasi A.A*. (2014). Integrating large-scale phylogenetic datasets to dissect the ancient evolutionary history of vertebrate genome . Molecular Phylogenetics and Evolution. 78: 1-13. *Corresponding Author
Asrar Z , Haq F, Abbasi A.A*. (2013). Fourfold paralogy regions on human HOX-bearing chromosomes: Role of ancient segmental duplications in the evolution of vertebrate genome, Molecular Phylogenetics and Evolution . 66(3): Pages 737–747. *Corresponding Author
Abbasi A.A*, Hanif H (2012). Phylogenetic history of paralogous gene quartets on human chromosomes 1, 2, 8 and 20 provides no evidence in favor of the vertebrate octoploidy hypothesis. Molecular Phylogenetics and Evolution . 63:922-927. *Corresponding Author.
Abbasi A.A.*, (2011). Molecular evolution of HR, a gene that regulates the postnatal cycle of the hair follicle . Sci. Rep. 1, 32; DOI:10.1038/srep00032. *Corresponding Author
Abbasi A.A.*, (2011). Evolution of vertebrate appendicular structures: Insight from genetic and palaeontological data .Developmental Dynamics. 240:1005-1066. (Special issue on limb development). *Corresponding Author
Abbasi A.A.*, (2010). Unraveling ancient segmental duplication events in human genome by phylogenetic analysis of multigene families residing on HOX cluster paralogons . Molecular Phylogenetics and Evolution. 57: 836-848.*Corresponding Author
Abbasi A.A.*, (2010). Piecemeal or big bangs: correlating the vertebrate evolution with proposed models of gene expansion events . Nat Rev Genet 11(2):166. *Corresponding Author
Abbasi A.A*., (2008). Are we degenerate tetraploids? More genomes, New facts . Biology Direct 3:50 (Highly accessed).*Corresponding Author
Abbasi A.A*, Grzeschik KH (2007). An insight into the phylogenetic history of HOX linked gene families in vertebrates . BMC Evol Biol 7:239. *Corresponding Author