The PAHG database (Phylogenomic Analysis of the Human Genome) offers insights into the evolutionary history of human multigene families and paralogous regions.
This project is funded by Higher Education Commission of Pakistan.
The phylogenomic analysis of 1247 gene members of 221 gene families residing 58 families on four-fold and 163 on three-fold representation paralogy blocks which was conducted, and results were incorporated in the database. Present database deals with evolutionary history of 5% of human protein coding genes and our aim is to keep moving in this domain to cover phylogenetic history of all possible human protein coding gene families. We are also building a library which will work in R so that a user can access data by using an R interpretor. To increase the efficiency of database operations, dynamicity would be integrated into the graphical images. This database will help out Evolutionary Biologists, Geneticists, Biochemists, Biotechnologists, Bioinformaticians and researchers from versatile biological communities to obtain evolutionary histories of human genes of their interest/human multigene families/human paralogy blocks in an interactive graphical manner.
Data, sequences, and other information at this site are accessible for the public. However, they are not guaranteed to be accurate as this is an ongoing research. Data will be updated from time to time. When using data obtained from this website, it is important to cite the original publications and contributors of that data and the database. Please see "Citing the database" section below.
If a specific page of the database has been used, we would be pleased if you cite us in your article. Please use the following format: Azhar, R., Malik, M.F., Arif, R., Khokhar, M.W., Abbasi, Y.M., Batool, F., Jalalzai, M.H., Bao, Y., & Abbasi, A.A. PAHG: the database of human multi-gene families. BMC Genom Data 26, 74 (2025).
Azhar, R., Malik, M.F., Arif, R., Khokhar, M.W., Abbasi, Y.M., Batool, F., Jalalzai, M.H., Bao, Y., & Abbasi, A.A. PAHG: the database of human multi-gene families. BMC Genom Data 26, 74 (2025).
Batool, F., Pervaiz, N., Khalid, Q., & Abbasi, A.A. Evolution of Human Multigene Families. Encyclopedia of Life Sciences.
Nawaz, S.M., Asghar, R., Pervaiz, N., Ali, S., Hussain, I., Xing, P., Bao, Y., & Abbasi, A.A. Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders. BMC Ecology and Evolution.
Pervaiz, N., Shakeel, N., Qasim, A., Zehra, R., Anwar, S., Rana, N., Xue,Y., Zhang, Z., Bao,Y., & Abbasi, A.A. Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals. BMC Evolutionary Biology.
Seemab, S., Pervaiz, N., Zehra, R., Anwar, S.,Yiming Bao & Abbasi, A.A. Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene. BMC Evolutionary Biology
Naz, R., Tahir, S., Abbasi, A.A., (2017). An insight into the evolutionary history of human MHC paralogon. Molecular Phylogenetics and Evolution.
Hafeez, M., Shabbir, M., Altaf, F., and Abbasi, A.A. (2016). Phylogenomic analysis reveals ancient segmental duplications in the human genome. Molecular Phylogenetics and Evolution. 94: 95-100.
Pervaiz, N., Abbasi, A. A.(2016). Molecular evolution of WDR62, a gene that regulates neocorticogenesis. Meta gene, 9, 1-9.
Siddiqui, I. J., Pervaiz, N., Abbasi, A. A.(2016). The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication. Scientific reports , 6.
Abbasi, A. A. (2015). Diversification of four human HOX gene clusters by step-wise evolution rather than ancient whole-genome duplications. Development genes and evolution, 225(6), 353-357.
Ajmal, W., Khan, H., Abbasi, A.A., (2014). Phylogenetic investigation of human FGFR-bearing paralogons favors piecemeal duplication theory of vertebrate genome evolution. Molecular Phylogenetics and Evolution. 81: 49-60.
Ambreen S , Khalil F , Abbasi A.A. (2014). Integrating large-scale phylogenetic datasets to dissect the ancient evolutionary history of vertebrate genome . Molecular Phylogenetics and Evolution. 78: 1-13.
Asrar Z , Haq F, Abbasi A.A. (2013). Fourfold paralogy regions on human HOX-bearing chromosomes: Role of ancient segmental duplications in the evolution of vertebrate genome, Molecular Phylogenetics and Evolution . 66(3): Pages 737–747.
Abbasi A.A, Hanif H (2012). Phylogenetic history of paralogous gene quartets on human chromosomes 1, 2, 8 and 20 provides no evidence in favor of the vertebrate octoploidy hypothesis. Molecular Phylogenetics and Evolution . 63:922-927. .
Abbasi A.A., (2011). Molecular evolution of HR, a gene that regulates the postnatal cycle of the hair follicle . Sci. Rep. 1, 32; DOI:10.1038/srep00032.
Abbasi A.A., (2010). Unraveling ancient segmental duplication events in human genome by phylogenetic analysis of multigene families residing on HOX cluster paralogons . Molecular Phylogenetics and Evolution. 57: 836-848.
Abbasi A.A., (2010). Piecemeal or big bangs: correlating the vertebrate evolution with proposed models of gene expansion events . Nat Rev Genet 11(2):166.
Abbasi A.A, Goode DK, Amir S, Grzeschik KH (2009). Evolution and functional diversification of the GLI family of transcription factors in vertebrates. Evolutionary Bioinformatics 5: 5-13.
Abbasi A.A., (2008). Are we degenerate tetraploids? More genomes, New facts . Biology Direct 3:50 (Highly accessed).
Abbasi A.A, Grzeschik KH (2007). An insight into the phylogenetic history of HOX linked gene families in vertebrates . BMC Evol Biol 7:239.