Table: Families analysed for HOX paralogon

List of human gene families inhabiting Human Chromosomes 2/7/12/17 which were used in the phylogenetic analysis of HOX paralogon. Please click on particular family to view its members.

  HOX Paralogon Summary

  Paralogon:  
Hsa: 2/7/12/17   

  Number of Families:  
62   

  Number of Family Members:  
362   

  Number of Sequences:  
4419   

Gene Family Name Years Number of Included Taxa Functions Number of Sequences Included
Solute carrier family 4 (SLC4) 2007 9 Inorganic anion exchanger activity, Bicarbonate transport, Chloride transport. 37
Fibrillar collagens (COL) 2007 11 Extracellular matrix structural constituent, Structural constituent of bone, Phosphate transport, Cell adhesion, Skeletal development, Perception of sound. 40
Erb-b2 receptor tyrosine kinases (ERBB) 2007 9 Epidermal growth factor receptor activity, Protein serine/threonine kinase activity, Electron transporter activity, Cell proliferation, ATP binding. 29
GLI zinc-finger protein family (GLI) 2007 13 Regulation of transcription from RNA , polymerase II promoter, Morphogenesis of limb and brain. 29
Hedgehog signaling molecule family (HH) 2007 14 Mesodermal cell fate determination, Proteolysis and peptidolysis, Cell-cell signaling, Intein-mediated protein splicing. 32
Inhibin subunits (INH) 2007 15 Cytokine activity, Growth factor activity, Induction of apoptosis, Mesoderm development, Defense response. 39
Insulin like growth factor binding proteins (IGFBP) 2007 12 Regulation of cell growth, Signal transduction, Skeletal Development, Cell proliferation. 38
Integrin beta subunits (ITGB) 2007 8 Receptor activity, Cell-matrix adhesion, Integrinmediated Signaling pathway. 33
Myosin light chains (MYL) 2007 14 Phosphoprotein phosphatase activity, Structural constituent of muscle, Muscle development, Microfilament motor activity. 45
Sp transcription factors (SP) 2007 9 RNA polymerase II transcription factor activity. 36
Zinc finger protein subfamily 1A (ZNFN1A)/(IKZF) 2007 10 DNA-dependent regulation of transcription, Specification and the maturation of the lymphocyte. 30
ATP synthase, H+ transporting, mitochondrial F0 complex (ATP5G/ATP5MC) 2010 18 Lipid binding, Hydrogen ion transmembrane transporter activity, Transporter activity, Protein binding. 29
Calcium binding and coiled-coil domain (CALCOCO) 2010 21 Transcription coactivator activity, Protein binding, Protein homodimerization activity. 41
Chromobox family (CBX) 2010 14 Chromatin binding, Enzyme binding, DNA binding, Protein binding, Transcription repressor activity, Ubiquitin-protein ligase activity. 71
Heterogeneous nuclear ribonucleoprotein A (HNRNPA) 2010 16 Nucleotide binding, RNA binding, Protein binding. 37
Nuclear factor (erythroid-derived) (NFE) 2010 21 Transcription factor activity, Transcription coactivator activity, Protein N-terminus binding, Sequence-specific DNA binding, WW domain binding, Protein dimerization activity. 51
Oxysterol binding proteins (OSBP) 2010 21 Protein binding. 55
Phosphodiesterase 1 Calmodulin-dependent (PDE1) 2010 25 Calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, Hydrolase activity, Calmodulin binding 46
Rho family GTPase (RND) 2010 18 GTP binding, GTPase activity, Nucleotide binding, Protein binding. 35
Secernin (SCRN) 2010 25 Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. 52
Sorting nexins subfamily 1 (SNX) 2010 10 Protein binding, Phosphoinositide binding, signal transducer activity, Receptor binding. 23
WAS/WASL interacting protein family (WIPF) 2010 15 Actin binding, Profilin binding. 31
Amiloride-sensitive cation channel neuronal (ACCN)/(ASIC) 2013 20 Ligand-gated sodium,Channel activity, Protein binding,Ion channel activity. 60
ATPase H+ transporting V0 Subunit A (ATP6V0A) 2013 23 Hydrogen ion transmembrane transporter activity, ATPase binding, Insulin receptor signaling pathway, ATP hydrolysis coupled proton transport. 74
Calcium voltage-gated channel auxiliary beta subunits (CACNB) 2013 14 Voltage-gated ion channel activity,High voltage-gated calcium channel activity, Protein binding. 46
Carbohydrate sulfotransferases (CHST) 2013 17 Sulfotransferase activity, Transferase activity, Cell adhesion. 84
CAP-GLY domain containing linker protein (CLIP) 2013 28 Nucleic acid binding, Protein homodimerization activity, Microtubule binding, Positive regulation of microtubule polymerization. 89
FKBP prolyl isomerases (FKBP) 2013 25 FK506 binding,Peptidyl-prolyl cis-trans isomerase activity,Calcium ion binding 104
Formin-like (FMNL) 2013 21 Actin binding, Profilin binding, Rho GTPase binding, Substrate-dependent cell migration. 50
Growth factor receptor-bound proteins (GRB) 2013 27 Protein binding, SH3/SH2 adaptor activity, Leukocyte migration, Epidermal growth factor receptor. 67
Histone deacetylases, class II (HDAC) 2013 17 Histone deacetylase binding, Potassium ion binding, Hydrolase activity, Activating transcription factor binding, Sequence-specific DNA binding. 61
Inhibitor of growth family (ING) 2013 18 Protein binding,Zinc ion binding, Metal ion binding, Histone acetyltransferase activity, Transcription coactivator activity. 70
Neurexophilins (NXPH) 2013 13 Protein binding, Receptor binding, Neuropeptide signaling pathway. 34
ORM1-like (ORMDL) 2013 15 Protein binding. 30
Pyruvate dehydrogenase kinase (PDK) 2013 20 Pyruvate dehydrogenase (acetyl-transferring) kinase activity, Two-component sensor activity, Protein heterodimerization activity, ATP binding. 67
Pleckstrin homology domain containing, family A (PLEKHA) 2013 26 Phospholipid binding,1-phosphatidylinositol binding, Glycolipid transporter activity, Glycolipid binding. 41
Protein phosphatase 1 regulatory 1 subunits (PPP1R1) 2013 18 Protein binding, Protein serine/threonine phosphatase inhibitor activity, Protein kinase inhibitor activity, Receptor binding. 38
Protein kinase gamma subunit (PRKAG) 2013 26 Protein binding, CAMP-dependent protein kinase activity, AMP binding, CAMP-dependent protein kinase regulator activity, Protein kinase binding, Phosphorylase kinase regulator activity. 63
Transmembrane protein 106 (TMEM106) 2013 24 "Putative transmembrane protein, molecular function unknown" 46
Tensin (TNS) 2013 25 Actin binding, Protein binding. 74
Vesicle-associated membrane protein (VAMP) 2013 15 Protein binding, Syntaxin binding, Phospholipid binding, Calmodulin binding. 59
Zinc finger protein 385 (ZNF385) 2013 17 Protein binding, Zinc ion binding, DNA binding, Metal ion binding, Nucleic acid binding. 51
Receptor (G protein-coupled) activity modifying protein (RAMP) 2013 18 Coreceptor activity, Protein transporter activity, Intracellular protein transport. 44
ATP binding cassette subfamily A,G (ABCA, ABCG) 2014 18 ATPase activity, nucleotide binding, ATPase activity coupled to transmembr-ane movement of substances, ATP binding, Cholesterol absorption, transport. 142
Bromodomain containing (BRD)/(BAZ)/(BPTF)/(KAT)/(CERC) 2014 27 Zinc ion binding, DNA binding, Ubiquitin-protein ligase activity, Histone acetyltransferse activity, Transcription cofactor activity 136
Chaperonins (CCT) 2014 27 Unfolded protein binding, ATP binding, Catalytic activity, The complex folds various proteins including actin and tubulin. 171
Cyclin dependent kinases (CDK) 2014 28 Cyclin-dependent protein kinase activity, Transferase activity , Protein serine/threonine & tyrosine kinase activity, Signal transducer activity. 183
Beta-gamma crystallins (CRYB, CRYG) 2014 19 Structural constituent of eye lens, Visual perception. 110
G protein-coupled receptors, Class F frizzled (FZD) 2014 21 G-protein coupled receptor activity, Transmembrane receptor activity, Frizzled signaling pathway. 102
Integrin alpha subunits (ITGA) 2014 16 Protein binding, Cell-matrix adhesion, Integrin mediated signaling pathway, Integrin complex. 146
Potassium voltage-gated channel, subfamily H (KCNH)/(CNG) 2014 15 Calmodulin binding, Voltage-gated potassium channel activity, Signal transducer activity, Nucleotide binding, cGMP binding, Intracellular cAMP activated cation channel activity. 103
Potassium inwardly rectifying channel subfamily J (KCNJ) 2014 27 Amino acid-polyamine transporter activity, Sodium symporter activity, Oxygen transporter activity, Structural constituent of ribosome. 239
Methyltransferase (METTL) 2014 27 Methyltransferase. 56
MLX interacting protein (MLX) 2014 15 Transcription factor activity, Regulation of transcription, DNA dependent, Transcription. 28
Myosin heavy chains, class I (MYO1) 2014 28 ATP binding, ATPase activity, Calmodulin binding, Actin binding, Microfilament motor activity. 161
Nascent polypeptide associated complex subunit alpha & domain proteins (NACA) 2014 18 Protein biosynthesis, Nascent polypeptide association, Nascent polypeptide associated complex. 29
Neuronal differentiation (NEUROD)/Neurogenin (NEUROG) 2014 23 RNA polymerase II transcription factor activity, Double-stranded DNA binding, E-box binding. 89
Rap guanine nucleotide exchange factor (RAPGEF) 2014 27 Calcium ion binding, Signal transducer activity, Protein binding, Rap guanyl-nucleotide exchange factor activity, CAMP-dependent protein kinase regulator activity, cAMP binding. 95
Ring finger protein subfamily 1 (RNF) 2014 21 Ubiquitin-protein ligase activity, Peptidase activity, Zinc ion binding, Protein ubiquitinition, Proteolysis, Peptidolysis, Ubiquitin ligase complex. 114
Solute carrier family 38 (SLC38) 2014 28 Amino acid-polyamine transporter activity, Oxygen transporter activity, Structural constituent of ribosome. 128
Solute carrier family 5 (SLC5) 2014 28 Sodium-dependent multivitamin transporter activity, Biotin binding, Transporter activity, Symporter activity, Ion transport, Sodium ion transport. 126
Suppressors of cytokine signaling (SOCS) 2014 26 SH3/SH2 adaptor activity, Insulin-like growth factor receptor binding , Prolactin receptor binding, Protein kinase inhibitor activity. 150