>Homo sapiens GLI1
MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
PNMAVGNMSVLLRSLPGETEFLNSSA
>Mus musculus GLI1
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETS
SCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSP
GGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQARGPRATC
QLKSELDMMVGKCPEDPLEGDMSSPNSTGIQDHLLGMLDGREDLEREEKPEPESVYETDC
RWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTG
EKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHS
NEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKRE
REGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDL
SSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVS
LDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARG
SGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFK
SLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLN
PYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPEN
WGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSE
GSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLV
CNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPA
SANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPE
VGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTP
SPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
>Rattus norvegicus GLI1
MFNPMTSPQVNSYGEPCCLRPLPSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGSARETS
SCTEGSLFPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
YGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTQGSMMLHPQSRGPRATCQLK
SELDIMVGKCPEEPLEGDMSSPNSTSTQDHLLGMLDGREDLEREEKPEPESVYETDCRWD
GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEK
PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREG
GSGREESRLTVPEGTMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSL
DEGPCVAATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDR
RSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLTPAQHYMLRARYASARGSGT
PPTAAHSLDRIGGLPAPPWRSRAEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLG
CVHTPPSVATGRNFDPHLPTSVYSPQPPSITENVAMDTRGLQGELEVGTSMMGNDLNPYM
DFSSADTLGYGGPEGTAAESYGSKGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPETWGE
FPSHAGVYPGTKALGTAYNQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSP
DPQPLFSHHSQLPPPQYLQSGPYPQPPHDCLSLESRPGLNFNPSSHSTGQLKAQLLCNYV
QSQQELLWEGRSRGGIPNQELPYQSPKFLGGSQVSQSPTKVPAAAAAATFGSGFASPALA
NHKSVSYPAPSPCHETFTMGVNRPPHRPAAPPRLLPPLPPCYGPLKVGDANPSCGHPEVG
RLGAGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEAQGLSPPPSHEQGDSSKNTPPP
SGPPNMAVGNMSVLLGSLPGETQFLNSSA
>Tetraodon nigroviridis GLI1
MYNPMTSAIAHGAGTGIGLCTDQYMRPPQALPPHSMMGHRGMPPPEGGNSTPYCNQSNMM
PSHHNFCQAQGNSDQIGSGDGSRFSTPRSMLKLSKKRALSISPLSDASVDLQTVIRTSPN
SLVAFVNSRGNANGASSYGHLSVGAMSPSLGYTSNISCQSRQQGSLYGGGGVTPLGHTPG
PCQGSRLPPHNPRLHAPPKHGHLKTEPGLSSVMDGMNVKSLEERSEGDVASPSSTGTQDP
LLGLLDGRDDLDKEDGKPEQEAIYETNCHWESCNKEFDTQDQLVHHINNEHIHGEKKEFV
CHWQDCSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEK
PYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGP
EAHITKKHRGDTGPRPPGSAMTPGGQSSELLLEKEEARRDDCKLMAPETSLKSQPSPGGQ
SSCSSERSPLGSANNNDSGVEMNLNAAGSLEDLTALEDGVGGGGGGGGEPGNVGGTMAMS
AQALKRLENLKIDKLKQICRPSPPARCAGSKLPAIPGTGDNMGMCVPPPLLSNRRVMELS
SHELGGSASVGCSNDRRGSGTSSLSSAYTVSRRSSMVSPYLSSRRSSEVSQMGGTAGGGC
HSFGSEIVADPLSPETNRRGAPCPGGGLPGLSNLTPAQQYNLKAKYAAATGGPPPTPLPN
MEQMGATTARRGGYLSEYQGQPLPPFLTQGGPRRHSANTEYGTGVIYPHQAPGNNTRRAS
DPLSPGHDSLRCPDQAYMHGRYQNPGGDVSSKAGNSTGQARPFQSEGMSNSLLQQTEYSM
STCQLSPSAPHYPSIGQGGDAGGRWSDNHSHIPTPAHELQSQQGLQYTDAQHTHFNSQPG
LYNSPGGTHKLVIKPEQQFHVGMGGRDACQSAKLQQQRMLLQQAQGYPQPAGAVMMRNSS
SSNCGFQAQNQTTFASGGSVSLGCAGKALSDGQRSETPMMQVKEMMVRNYVQSQQALMWE
QQQEQQQQNPTGDSKSVPLSPYAESGPIANALENLDLDNTRIDFTSIIEDAESSSFGPIN
NTLEGQPGPSSQASSRLTTPQNSVSLSAESGLSNMAVGDMTSMLTSLAGENKFLNTLS
>Gasterosteus aculeatus GLI1
MPVDMQPHQGLYHYETSPSHPSRGLVPSDQSPYTDVSSLRAPLLNGHPQDCRAMYNPMTP
SMAHGSGQGIGNCMDQYMRPPQAPPPHSMMGHRGMPPTDGGNSTAYCNQNNMMSSHHNFC
QFQSSSDQIGSGDGSRFSTPRSILKLSKKRALSISPLSDASVDLQTVIRTSPNSLVAFVN
SRCNPNGASSYGHLSVSAMSPSLGYSSNINCQSRQQVSMYGGGGGTPLGGHSTGPCQASR
LPPHNPRLHAPPKHGHLKTEPGLGGVMDGMNVKSLEERSEGDVASPSSTGTQDPLLGLLD
GRDDLDKEDGKPEPEAIYETNCHWESCNKEFDTQDQLVHHINNEHIHGEKKEFVCHWQEC
SREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEH
EGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITK
KHRGDTGPRPPGSAMTPGGQSSELLLEKEETRREDCKLLAPETTLKSQPSPGGQSSCSSE
RSPLGSANNNDSGVEMNLNAAGSLEDLTALEDGVAGGGEPVGVGTMGMSSQALKRLENLK
IDKLKQIRRPTPPGRCSNNRLPALPGPGENMGMCAPSPLLSNRRVMELSNHELGGGAPIG
CSSNDRRGSGTSSLSSAYTVSRRSSMVSPHLSSRRSSEVSQMGGTGGGGCHHLSAEKSVG
DPLSPETNRRGAPCPGGGLPGLPNLTPAQQYSLKAKYAAATGGPPPTPLPNMEQPGTPAR
RGVLSEYQGQPLPPFLQKGGPRRHSANTEYGTGVIYPHQAPGNHSRRASDPVRSVADPQA
LPKRFNSLNNVAMMGRRNALHRGSDTSLARHLYSPRPPSITENVMMEAMGMEPHLAPIDA
RDRSMMMPPGERSFMGYQQQHQSLGGVGGPLGNQLSPSHDSLSCPDQVYMQGPYQNQGGE
VTSRAGGNPMGQVRPIHSEGISNALLQQAEYSMSTCQLSPSGPHYPSIGQGGDAGGPWSD
SHGQNQRGLQYSDPSLQPQQTQAHFNNQTGLYSSPDGTHKLTIKPEQQFHPGMGGGNACQ
SAKLQQQQRMLVQQPQGYPQQTGQVLMGNSNNPSCDFQGQNQNSFPAAGGLSLGCAGTAL
ADGQRSETPMMQVKEMMVRNYVQSQQALMWEQQQEQQQQSGIKPPPLSDNMDMSGQTAIM
QHSPQHQNQTLYSSQPYPSYPNQNLAMSPPGHSRGPGSVTPKDQQLAGLQVSCYGQEMVV
PRPPQGRKPLSRQNSLSQVGVGYLGSPPHLSPVHSASSPRRVVRLPPVQHPQHQQNEMFS
PSNNNMYYSGQISMDMDKHMDPQIGTCLNQPHTMRSNLDPTGGTKTSPMTPYPESGPISN
ALEHLDLDNARIDFTSIIDDAESSSFSPINNPLHGLPGSSSQASSRLTTPQTSGLSNMAV
GDMTSMLTSLAGENKYLNTLS
>Danio rerio GLI1
MPVDMQPHQGLYHYDNTSNQPSRGLAPSVRSPYSSEASSVCVALSGGQSVNSREMYNPSM
APGACMEPYMRAPHAPPPHSMMGHRGMPPPEGMSGAPYCNQNMMTSHHNLPHNQHTSELM
ASGDASCFSTPRSMLKLSKKRALSISPLSDASVDLQTVIRTSPNSLVAFVNSRCGPNNPS
SYGHLSVGTMSPSLGFSSSINYSRPQGNIYSHPVPSCIGAPARLPPHNPRLHTPAKHTHL
KTEPVLGSVMDSINIKGLEDHSEGDVASPSSTGTQDPLLGLLEGRDDLDKEEKPEPEAIY
ETNCHWESCSKEFDTQEQLVHHINNEHIHGEKKEFVCHWKDCSREQRPFKAQYMLVVHMR
RHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQN
RTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDTGPRPPGLTTAGQ
SSELLIEKEERNREDCKLLAPDNTLKSQPSPGGQSSCSSERSPLGSANNNDSGVEMNLNA
AGSLEDLTTQEDSGNAGVSESSATISSGGMCMSVQALKRLENLKIDKLKQIRRPTPPGRN
AGNKLPALSATGEMMSMCAPSPLLSNRRVMELSAPDMGGVTGMSCPPNDRRGSGTSSLSS
AYTVSRRSSMVSPYLSSRRSSDVSHCQSVMGGEVPGDPLSPQNSQRAGLCQNSGGLPGLP
SLTPAQQYSLKAKYAAATGGPPPTPLPNMDQAGTPARHVGFLRECQGQPLPPFLQQGGTR
RHSANAEYGTGVIYPHQAPGNNTRRASDPVRSAADPQGLPKVQRFNSLSNVSLMSRRNAL
QQCGSDAALSRHMYSPRPPSITENVMMEAMGMDGNTEGRQQGNMIPGGDRSYMGYQHNPH
QASQLSPGQESLGCIDQVYQSQMQGQYQREESCSTGVMGQADIANNLLQQAEYGMSTCQL
SPSGPHYPSQGDGSGPWGQTNQLHSPGMQYQGAGMQGQHYTQQGIYDPTSNPNLQRVTVK
PEQFHPSMGGSSSCQNTKALHQNRHNANMQTYPLQGQGIMNRSSSASCDFHHSQMGTQPN
QGGSFQSGTGINLALAESRRSQTPMHQMKEMMVRNYVQSQQALLWEQQQEQSVSEKPDGM
DMGQTQMMQHSPQHQQANQNLYPGNTYQGYPNQNLMSPQQNRVPGSVKEQMQSSCYGPDM
IPRPPQVRKSLSRQNSLSQQAGGAYLGSPPHLSPVHSTASPRRGVRLPPVQQQQQQQQQH
SENFNNNNNPMYYSGQMHMHHDLEKTPEGPCLAQQHLTSSDPTTKPTSISYPDPAPMSNA
LEHLDLENAQIDFTSIIDDQEPSSYSPINAPIGHNQCSSQTSSRLTTPQNSITLPSGLSN
MAIGDMSSMLTSLAGENKYLNTLS
>Takifugu rubripes GLI1
MPVDMQPHQGLYHYDSSPGQPSRGLVPSDQSPYSDVSSLRAPFLNGLPQDCRTMYNPMAS
SMTHGSGPGIGLCTDQYMRPPQALPPHSMMGHRGMPPPEGGNSTPYCTQSNMMPSHHNFC
QAQGNSDLIGSGDGSRFSTPRSILKLSKKRALSISPLSDASVDLQTVIRTSPNSLVAFVN
SRGNANGASSYGHLSVGAMSPSLGYTGNISCQSRQQGSIYGGGGVTPLGGHTPGPCQGSR
LPPHNPRLHAPPKHGHLKTEPGLSGVMDGMNVKSLEERSEGDVASPSSTGTQDPLLGLLD
GRDELDKEDGKTEQEAIYETNCHWESCSKEFDTQDQLVHHINNEHIHGEKKEFVCHWQEC
SREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEH
EGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITK
KHRGDMGPRPPGSAMTPGGQSSELLLEKEETRRDDCKLMAPETSLKSQPSPGGQSSCSSE
RSPLGSANNNDSGVEMNLNAAGSLEDLTALEDGVGGGGGGESASAGGTMGMSAQALKRLE
NLKIDKLKQICRPSPPARCGSNKLPALPGTGENLGMCVPSPLLSNRRVMELSSHELGGSA
SAGCSNDRRGSGTSSLSSAYTVSRRSSMVSPYLSSRRSSEVSQMGGTAGGGCHVFGSEQI
VADPLSPETNRRGAPCPGAGLPGLSNLTPAQQYNLKAKYAAATGGPPPTPLPNMEQIGTT
ARRGGVLSEYQGQPLPPFLTQGGPRRHSANTEYGTGVIYPHQAPGNNTRRASDPVRSAAD
PQALPKRFNSLNNVALMGRRNALQHRGSDTSLSRHLYSPRPPSITENVMMEAMSMDTHLT
PLDSRDHSMMMPPGERSFIGYQQQHQAHGGGASLSNQLSPSHDSLSCPDQAYMHGCYQNP
GGDVTSKDGNSIGQARPHQSEGMTNTLLQQTEYSMSTCQLSPSAPHYPSISQSGNAGGRW
GNNHSQIQSSPHELQSQQGMQYTDASLQSQQTHFNNQPGLYNGPGGTHKLVIKPEQQFHP
VMGGRDACQSAKLQQQRMLLQQTQGYPQQTGQVMMRNSSNSSCGFPVQNQNTFASGGSVS
LGCAGKALSDGQRSETPMMQVKEMMVRSYVQSQQALMWEQRQEQQQQSGIKPALSDNVDL
AAQTAMIQHSPQHQNQNLYPNQPYPSYPNQNMIMSPPSRGPSSVPPKDQQLTGLQGSCYG
QEMAPRPPQGRKPLSRQNSLSQVGGVYIGSSPHLSPVHSSSPRRGVRLPPVQHPQHPQNE
MFSPSNNNNNLYCSGQVNLDKIIDSQNGPCLNQQHGMGSGLDPTSDPKSAPLGPYPESGP
ISNALENLDLDNTRIDFTSIIDDAESSSFGPVNSTLQGQPGSSPQASSHLTTPQTSMSLT
AGSGLSNMAVGDMTSMLTSLAGENKYLNTLS
>GLI2 Homo sapiens
METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHA
PLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHP
YVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQM
TLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSD
ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL
SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSES
AVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKED
LDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTRE
QKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGC
NKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQR
NDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGA
QSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLR
KHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPA
GLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASP
LGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGP
PPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHE
APGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLA
RGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDE
GTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKN
NMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDS
TQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTIS
GALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQS
YPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPT
GRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAP
DHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTV
DSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGI
SNMAVGDMSSMLTSLAEESKFLNMMT
>Mus musculus GLI2
METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAVAAAVAAHGVPQQLLPAFHAPLPI
DMRHQEGRYHYDPHSVHSVHGPPTLSGSPVISDISLIRLSPHPAGPGESPFSAHHPYVNP
HMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQMTLMA
SHPTPYGDLLMQSGGAASAPHLHDYLNPVDASRFSSPRVTPRLSRKRALSISPLSDASLD
LQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQR
GLGSAFGHTPPLIQPSPTFLAQQPMTLTSISTMPTQLSSSSSNCLNDANQNKQNSESAVS
STVNPITIHKRSKVKTEAEGLRPASPLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCH
WADCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGE
KPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSN
EKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHVRAPLLKENGDNEASA
EPGGRGPEESVEASSTSHTVEDCLHIKAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNN
DSGMEMPGTGPGSLGDLTALADTCPGADTSALAAPSTGGLQLRKHMSTVHRFEQLKREKL
KSLKDSCSWAGPAPHTRNTKLPPLPVNGSVLENFNNTGGGGPAGLLPSQRLPELTEVTML
SQLQERRDSSTSTMSSAYTVSRRSSGISPYFSSRRSSEASPLGGLRPHNASSADSYDPIS
TDASRRSSEASQCSGGGPGLLNLTPAQQYNLRAKYAAATGGPPPTPLPGLDRVSLRTRLA
LLDAPERALPGACPHPLGPRRGSDGPTYSHGHGHGYAGAAPAFPHEGPNSSTRRASDPVR
RPDPLILPRVQRFHSTHNMNPGSLPPCADRRGLHVQSHPSVDSNLTRNAYSPRPPSINEN
VVMEAVAAGVDGPGLECDLGLVEDELVLPDDVVQYIKAHTGGTLDDGIRQGYPTEGTGFP
ENSKLPSPGLQGHRRLAAADSNMGPSAPGLGGCQLSYSPSSNLNKSNMPVQWNEVSSGTV
DALPTQVKPPPFPHSNLAVVQQKPAFGQYPGYNPQSVQSSSGGLDSTQPHLQLRGAPSAS
RGSYTQQPRQPAAGSQCLGMSAAMSPQASYSQAHPQLSPNIVSGSLNQFSPSCSNMAAKP
SHLGLPQQMEVVPNATIMNGHQREHGVPNSSLAAVSQPHPVLSYPQQDSYQQGSNLLSSH
QPGFMESQQNAGFGLMQPRPPLEPNTASRHRGVRSGQQQLYARTTGQAMVTSANQETAEA
MPKGPAGTMVSLAPQPSQDTGRAQDQNTLYYYGQIHMYEQNGGCPAVQPQPPQPQACSDS
IQPEPLPSPGVNQVSSTVDSQLLEPPQIDFDAIMDDGDHSSLFSGALSPTLLHNLSQNSS
RLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT
>Rattus norvegicus GLI2
MTLTSITVPTQLGSNSSNCISDANQNKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPAS
PLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIHG
EKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLR
SHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHV
KTVHGPDAHVTKKQRNDVHLRAPLLKENGDNEAGAEPGGRGPEESVEASSTSHTAEDCLH
IKAIKTESSGLCQSSPGAQSSCSSEPSPLGSVPNNDSGVEMPGTGPGSLGDLTALDDTSP
GADTSALAVPSTGGLQLRKHMTTMHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLP
VNGSVLENFNNTGGCGPAGLLPNQRLPELTEVTMLSQLQERRDSSTSTMSSAYTVSRRSS
GISPYFSSRRSSEASPLGGIRPHNASSADSYDPISTDASRRSSEASQCSGGGPGLLNLTP
AQQYSLRAKYAAATGGPPPTPLPGLDRVSLRTRLALLDAPERALPGACPQPLGPRRGSDG
PTYNHGHGYVGAAPALPHEGPNGSTRRASDPVRRPDPLVLPRVQRFHSIHNMNPGPLPPC
TDRRGLHLQSHPSVDGSLTRHAYSPRPPSINENVVMEAVAAGVEGAGLESDLGLVEDDLV
LPDDVVQYIKAHTGGALDDSTRQVYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMSPSA
PGLGGCQLSYSPSSSLNKSNMPVQWNEVSSGTVDALPTQVKPPSFPQSNLVQQKPAFAHY
PGYSPQALQSGSGGLDSTQPHLQLRGAPSASRGSYTQQPRLPATGSQCLGVTAAMSPQAN
YSQTHHQLSPNVVSGSLNQFAPSCSNMAAKPSHLGLPQQMEVVPNATIISGHQRELGIAS
SSLAAVSQPHPVLGYPQQDGYQQVSGLPSSHQPSFMESQQNTGFGLMQPRPPLEPNTASR
HRGVRSGQQQQQLYARTAGQAVVTSANQETAEAMPKGTAGTVVSLTPQPSQDTGRSQDQN
TLYYYGQIHMYEQNGGCPAMQPQPPQPQGCSDNIQPEPLPSPGVNQVSSTVDSQLLEPPQ
IDFDAIMDDGDHSSLFSGALSPSLLHNLSQNSSRLTTPRNSLTLPSIPVGISNMAVGDMS
SMLTSLAEENKFLNMMT
>Tetraodon nigroviridis GLI2
MAAPRLDAHPAPRPRGFSTSVSRFSSPRLTPRLSRKRALSISPLSDASIDLQTMIRTSPN
SLVAYINNSRSSSAASSSYGHLSVGPGIRNPVGGILDLSEDLDKDECKQEPEAVYETNCH
WEGCTKEYETQEQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGE
KPHKCTGCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTHSNEV
GPQLAAMPCSVHPNSELESPSFQKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKK
QRSDMAPRPQPPKGNGVNEANSRHGAKGVEGKLEANSTSGGMENCLQIKSIKTENSMMYQ
SSPGGHSSCSSEPSPLGSTNNNDSGVEMAMHSGGSFADLSAQDESPMVDSTVPAGGQQAG
VGLHLRKAVGHSGTVTIKLENIKKERLKTVSTSDWVSSAAQPLQGQRSSVKLPPIPAVGS
LLENSTMMSNSSVCYPGPRKGDLSSCEVTLLNQLNERRDSTTSTISSAYTVSRRSSGISP
GYSSRRSSEASQFGANRHNNVSSADSYDPISTDLSRRSSEASQCGVGGGATLLSLTPAQH
YRLKAKYAAATGGAPPTPLPNMDRMSLRTRMALYSDSQEASLHQFHQPPTGAVPRRCSDM
GYGTRSMMPHEVPSSLPRRASDPVRRPPLDPLSLPRVQRYNSMNNMNPLNVTTAERYQSL
LAQGYTRSDGNLQRYPFAPRPPSISENVAMENMAMDGMAGGDQNGEDDMVLPDDMVQYLR
SQNTDPSANNSCQVDYHSNHQNQGFQAGIAPPPAYYSQRRMAMVDASMPHSGQDSQQPFS
APPANTNKNNMPVQWNEVSSGTVDSTSKLSKQQHHPLRGNLAVVQQRHNFSSFQGPSQAL
SSNQQVVPMSQNVSTQAYANHSNQRLTHASQPQQQQQRQYIPANFGQHMSPQQGFGQEFI
PNSISGSTSMRPAQNGMASSEPQSYRARTQTDGYCRVNPMDVQQNYNVLTQQHQSIHSGA
RGSLQPRPPAEPRSSLRQHLGSNMMPPNRVPKSSALSPCDGNETSEASPKRCSGLAAQNS
NSENSVFYTGQIHMFEPSFDAPMSPCASEPPANSTTAASMASPGVNLVSSSTTDSSTGAS
GGAQHPQIDFDTMLDDGDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGN
MAIGDMNSMLTALAEESKFLNMMS
>Gasterosteus aculeatus GLI2
HLFPTFHTPIPIDMRHHEGRYHYEPHPLHAMHGPPGLTGSPVISDISLIRLSPHVAPGTG
ESPFSPPHHYVSPHMEHYLRSVHGSPTLSMISAARGLSPAEVTHEHLKERALFNLPPPPP
GANPTDYYHLMASASQRSPYGDLLIQSTAHLPEYISPMDVSRFSSPRLTPRLSRKRALSI
SPLSDASIDLQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGGISPSFSFPHPINPVA
YQQLLSHQRSLNAFGHTPPLIHPSPSSFSARQHPLAASPMTTSHNTSSSEANQCVNTCKN
ASGDPAVSSTVNPLSTKRSKVKTEAEGPLPISPSSQDHCGGILDLSEDLDKDECKQEPEA
IYVTDCHWEGCSKEYDTQDQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVH
MRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKH
QNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRSDAPPRPQPPRGD
GENGANSKIADGRVEANSTSRGVEDCLQVKSIKTENSMTYQSSPGGHSSCSSEPSPLSSA
NNNDSGVEMALHSGGSFGDLSALDDCPMVDSTVSAGGQQAGVGLQLRKAVGHVGTVTIKL
ENIKKERLKTVRDSCPWVNSAPQPPQGQRSSMKLPPIPAVGSLLESSNMISNLSGSYPGQ
RIGDLSSSEITLLNQLNERRDSTTSTMSSAYTMSRRSSGISPCYSSRRSSEASQFGTNRH
NNISSADSYDPISTDLSRRSSEASHCGGGGVGGGGLPSVLSLTPAQHYRLKAKYAAAIGG
APPTPLPNMDRMSLRTRMALYGDPQEGTLHPFHQPDFGTVPRRCSDIGYGTRSMMPHEVP
TSLPRRASDPVRRPTLDPLSFPRVQRYNSMNSMNPVNGPPAERHQALTMQGYTRSDGSLQ
RYPFAPRPPSISENVAMENMAVDGMIIGGEQGGEDDMVLPDDVVQYLRSQNSGPSGHNLG
QGDFHSNNLTKGYQTGMTSSASFYAQRRMAMADANMTQSGQDMQSQQPFSAPPGNVNKNN
MPVQWNEVSSGTVDTTKKLSKQHQHPLRGNLAVVQPRHNLGSFQGQGQGLGSNQQVVPMS
QNMSIQGYANHNSQRMMSIPPQQHQQLRQCNPVNMSEQMSPQQGFGQEIIPNSISGSTSV
RPTRNNMAVTEVHSYRARTQVDGYCHVNQVDQQQNYSVVSQQHNIHNGGRGMLQPRPPIE
PKAIARQQTGSSMMQPNRIPKSSDLNPSFGTDTSEASPKRPTGSSAHNCNSANPNSAMLY
SGQVHMFAPTSVSFDASMPPSASHAPASNTTAADHMASPGVNHVSSSTVDSSTNAAAGTE
HAQIDFDTLLDDGDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSVTLTSVPAGIGNMAIG
DMNSMLTALAEENKFLNLIS
>Danio rerio GLI2b
MEAGVPAPAEKKDCKSSPLEGNVFSEMPKKPSPSSLSRGPHHIFPTFHSPIPIDVRHHEG
RYHYDPHALHALHGPPGLAGSPVISDISLIRLSPGAAGEAFLPPHSYVSPHVEHYLRSAH
SSPTLSMISAARGLSPAEVAHEHLKERGLFGLPPPPGASPADYYHLMAGHRNPYGELLMQ
GAGAAAAAAHLPEYFTSVDVSRFPSPRMTPRLSRKRALSISPLSDASIDLQTMIRTSPNS
LVAYINNSRSSSAASSSYGHLSVGGISPSFPFPHSINPVAYQQLLTQQRGLSAFGHTPPL
IQPSPTFSSRHPLSLSTLPTPTTNDTETKNSNGESAVSSTVNPLGNKRSKVKTELGGPRP
VSPYSPEHLSSAQDLKEDMDDCKQEAELVYETNCHWEGCSKEYDTQEQLVHHINNEHIHG
EKKEFVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLR
SHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHV
KTVHGPEAHVTKKQRGDLPSRPHPPKENGENEAGAKMAEEKIEANSTTRGVEDYLQVKSI
KTENSMMYQSSPGGQSSCSSEPSPLGSASLHGGGVEPAGLSGGSVGDLSALDDVPIVDST
VSTGILGLHLRKNAGPAHRLTHLKQEKLKSVRDSCSWANTAPPAPCTKLPPINTGSLLDG
LCDPGLSISSPRLGDLCPGETTVLSQLVERRDSLASTVSSAYTFSRRSSGISPCYSSRRS
SQTSQPGGRHNNISSADSYDPISTDLSRRSSEASLYGGIFSLTPAQHYRLKAKYAAATGG
APPTPLPNIDCKTLLGDSHEIPIHPPLVPRRCSDTGYANRSVLPHEVTANITRRASDPVR
RIAAERHSLYNSVNPYPTLHPLASSRHFYSTSESNVNRQQYPPRAPSISENVMMETLPDD
MESCNGVEDGLMMADDAVQCITTQNADSPQHTGVAHRNQSFGSPQHCHLQRRLALVEGNM
NAVARQTASSQQTFPGSANATKIPMPVQWNEVSSGTVDSSRSQTKQGSGRGNLQQKQNLS
SFLNVNSNQQVGLMSHNLALSPVQRSVEFNSLRINQRQANAEFLHGYLQGSASNDISLGL
LNPSGKSLTVQPGGVQNNRVCAQAQSHATFPNNQGNYSQMSSNQQGYIVASQNVNGNLLL
QPRPPTEPKPYSTQHSGPTTTAAQSNFSPAYDTSEASPKKSSSMFYTGQIHMFDSSGAMP
CPSSVGSPETNQVSSTVDSSGADPPQIDFDAMLDDGDHSSLMSGTLSPALLRSLSQNSSR
LTTPRNSVTLPPVAAGISNMAIGDMSSMLTALAEESKFLNMMS
>Danio rerio GLI2a
METTSPTSTEKKELKPSVLDGSSFTDLPKKPSPTTASRAPHLFSTFHTPIPIDMRHHEGR
YHYEPHPLHPMHGPHGLAGSPVISDISLIRLSPHAAATGESPFNPPHPYVNPHMEHYLRS
VHSSPTLSMISAARGLSPAELTHEHLKERSLFGLPPPPPGANPSEYYHLIASHRSPYGDL
LMQTGAAAAHLPDYMSPVDMSRFPSPRLTPRVSRKRALSISPVSDASIDLQTMIRTSPNS
LVAYINNSRSSSAASSSYGHLSVGAISPSFTFPHPITPVAYHQLLSQQRGLNAFGHTPPL
LQPSPALSSRQQTLVAAAALNNTTSSSTSSSTADTSTESSQNAGGDPAVSSTVNPMIFKR
SKVKTEAEGPHPISPGSQDHLELREELDKDECKQEPEAVYETNCHWEGCAKEYDTQDQLV
HHISNDHIHGEKKEFVCRWVECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYS
RLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRY
TDPSSLRKHVKTVHGPEAHVTKKQRGDAPPKPHPPKGNGENEAHTKHVRGRTDGSGEANS
TTRGVEDCQHVKTIKTENTVMYQSSPGGQSSCSSEPSPLGSATNNDSGVEMAMHSGGSLG
DLSALDDTPVVDSTGSPGTSAGVGLQLRKNRAGLLQLEHIKKEKLKTVRDSCSWANAPPQ
VRNTKLPPIPSIDSLLDAPNMGTQMSVPPTQHLGDLSSYEMTMLNQLHERRDSSTSTMSS
AYISRRSSGISPCYSSRRSSEASQFGVRNNNVSSADSYDPISTDLSRRSSEASQCGGTGG
LPSLLNLTPAQHYSLKAKYAAATGGAPPTPLPNMDRMSLKTRMAMYNDSQDSSAHLHHAQ
GVVNSRRCSDTGYGAPGMMPHEVPANLPRRASDPVRRTTLDPLSLPRVQRFNSISNMNLS
RLPAYDRRAFNMQNNTWSDGSLHRHPFSQRPPSISENILMENMATDGGDQQGDDLVLPDD
MVQYLRSQNGNSNHDSGISVNGGHALEFHGNMTSQQQQFYGQRRMGMAGINGSHVEPVPE
QIADPQGMNKNNMPVQWNEVSSGSADAVSRVPKQQQQQLRGNLTVVQQKQNFGSYQGFGS
NQQIVPMSQNLASLQQAYPQRNIQRMNTVQQFRQSISNPCQNIGEQVNRQDLSYNSNQRL
ICNSMGPPNGRMVQNQELQNYRSNLMHMNNINQQNYVPLTQTAFQNAGRGLIQPRPPSEP
KPLNRQHSGSGMVQPNGCSLSNVNSSEASPKRPGEVGQHSNGNGTMYYSGEIHMLDNGID
YGSPMSPCTNQAPVASVSTMASPGVNQVTSTVDSTQSLDHTQIDFDAMLDDGDHSSLMSG
TLSPGLLQSISQNSSRLTTPRNSVTLASVPAGIGNMAIGDMSSMLTALAEESKFLNMMA
>Takifugu rubripes GLI2
MENSATTAAEKKECKSSGLDGSPSEIPKKLSPTTLSRGAHHLFPTFHTPIPIDVRHHEGR
YHYEPHPLHPMHGPPGLTGSPVISDISLIRLSPHAAPGSGESPFSPPHPYMSPHMEHYLR
SVHSSPTLSMISAARGLSPAEVSHEHLKERTLFSLPPPPPGANPTEYYHLMASQRSPYGD
LLMQSGEMGPHLFSKPFIGPLSAVSRFSSPRLTPRLSRKRALSISPLSDASIDLQTMIRT
SPNSLVAYINNSRSSSAASSSYGHLSVGPGISPSFGFPPHINPVAYQQLLSQQRGLSAFG
HTPPLIQPSPSSFSTRQHPLSASAMSAALNNSNSDTRGSFSSVCQSASGDPAVSSTVNPL
TTKRSKVKTEAEGLLPISPSSQDHGGGILDLSEDLDKDECKQEPEAVYETNCHWEGCTKE
YETQDQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF
EGCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCK
IPGCTKRYTDPSSLRKHVKTVHGPEAHITKKQRSDVPPRPQPPKGNGVNEANSRHGAKGV
EGKIEANSTSGGMEDCLQIKSIKTENSMTYQSSPGGHSSCSSEPSPLGSTNNNDSGVEMA
MHSGGSFGDLSAQDECPMVDSTVPAGGQQAVMGLHLRKAVGHPGTVTIKLENIKKERLKT
VSTSDWVNSAAQPLQGQRSSVKLPPIPAVGSLLENSTLMSNSSISYPGQRRGDLSSCEVT
LLNQLNERRDSTTSTISSAYTISRRSSGISPGYSSRRSSEASQFGANRHNNISSADSYDP
ISTDLSRRSSEASQCGGGGLGGGATLPSLLSLTPAQHYRLKAKYAAATGGAPPTPLPNMD
RMSLRTRMALYSDSQEASLNQFHQPSPGTVPRRCSDMGYGTRSMMPHEVPGNLPRRASDP
VRRPTLDPLSLSRFQRYNSMNNMNPLNVSTAERYQSLVTQGYTRSDGNLQRYPFAPRPPS
ISENVAMENMVMDGMTGADQNGEDDLVLPDDMVQYLRSQNTGPSANNLGQVDFHSNHQNH
GFQTGMAPPPSYYSQRRMAMVDATMTHSAQDSQQPFSAPPENMNKNNMPVQWNEVSSGTV
DSTAKLSKPQHHPLRGNLAVVQQRHNFSSFQGQGQALSSNHQVVPMSQNVSMQYVPVNFG
EHMSPQQGFGQEFIPNSISGSTSMRPAQNVVASSELQRGRTQTDGGSLQPRPPAEPKSNM
RQHPGSNMMHPNRVAKSSALSPCDGTETSEASPKRRSGPAAHNSSSENSVFYTGQIHMFE
PSFDAPMSPCASEPPANSTSAANMASPGVNLVSSSTIDSSTGVSGGPQHPQIDFDTMLDD
GDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGNMAIGDMNSMLTALAEE
SKFLNMMS
>Homo sapiens GLI3
MEAQSHSSTTTEKKKVENSIVKCSTRTDVSEKAVASSTTSNEDESPGQTYHRERRNAITM
QPQNVQGLSKVSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTVFAMDPRNGYMEP
HYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPHR
NPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHAGVSPAEYYHQ
MALLTGQRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPLS
DHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMH
QQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSE
SAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYET
NCHWEGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH
TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT
HSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHS
QSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPI
SNYSNSGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKL
ERLKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTM
LNMLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIST
DASRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRLALL
GDALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGVRRASDPVRTGSEGLALPR
VPRFSSLSSCNPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLTM
DADANLNDEDFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGDFDAPGLPDSHAG
QQFHALEQPCPEGSKTDLPIQWNEVSSGSADLSSSKLKCGPRPAVPQTRAFGFCNGMVVH
PQNPLRSGPAGGYQTLGENSNPYGGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYGNCLNR
QPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNFGLPVAPNESAGSMVNGMQNQDPVGQ
GYLAHQLLGDSMQHPGAGRPGQQMLGQISATSHINIYQGPESCLPGAHGMGSQPSSLAVV
RGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCSNLQNYS
GQFYDQTVGFSQQDTKAGSFSISDASCLLQGTSAKNSELLSPGANQVTSTVDSLDSHDLE
GVQIDFDAIIDDGDHSSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPAVHEHHQHGYRG
HEFFADLPSGRKQIPCSYAIGFRKKRLQPTEINRS
>Mus musculus GLI3
MEAQAHSSTATERKKAENSIGKCPTRTDVSEKAVASSTTSNEDESPGQIYHRERRNAITM
QPQSVQGLNKISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNGYMEP
HYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYPDLPFIRISPHR
NPTAASESPFSPPHPYINPYMDYIRSLHCSPSLSMISAARGLSPTDAPHAGVSPAEYYHQ
MALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPLS
DHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHMH
QQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTSE
SAVSSTGGPMHNKRSKIKPDEDLPSPGSRGQQEQPEGTTLVKEEADKDESKQEPEVIYET
NCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH
TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT
HSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHS
QSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPI
SNYSNSGLELPLTDGGSVADLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHIKL
ERLKQVNGMFPRLNPILPSKAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFTV
LNTLNRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIST
DASRRSSEASQGDGLPSLLSLTPVQQYALKAKYAAPTGGPPPTPLPHMERLSLKTKMALL
GEGRDSGVTLPPVHPPRRCSDGGGHTYRGRHLMPHDALANSVRRDSDPVRTVSENMSLAR
VQRFSSLNSFNPPNLPPSVEKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALEALTM
DADANLNDEDLLPDDVVQYLNSQNQTGYGQQLQSGISEDSKVAHEPEDLDLAGLPDSHVG
QEYPALEQPCSEGSKTDLPIQWNEVSSGTSDLSSSKLKCGQQRPRQQPRGFGLYNNMVVH
PHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYGSQL
NRQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDFSLSVAPNELAGNTVNGMQTQDQM
GQGYIAHQLLSGSMQHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDNSSQPSSMA
AIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLCSTVQN
YSGQFYDQTMGFSQQDRKAGSFSLSDANCLLQGTCTENSELLSPGANQVTSTVDSFESHD
LEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPIPIHGHHQHG
YRGYEFFADLPCRRKQVPCSYAVGGRQGGPQTQRLK
>Rattus norvegicus GLI3
HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSR
LENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYT
DPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKEL
SNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSIA
DLSAIDETPIMDSTISTATTALALQGRRNPAGTKWMEHIKLERLKQVNGMFPRLNPILPS
KAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFTVLNTLNRRDSNTSTISSAYL
SSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQGDGLPSLL
SLTPVQQYRLKAKYAAATGGPPPTPLPHMEKLSLKTRMALLGEGRDSGVTLPPVHPPRRC
SDGGGHTYSRRHLLPHDALANSARRASDPVRTVSENMSLPRVQRFSSLNSFNPPNLPPSV
EKRSLVLQNYTRQESTHPRYFQASPCPPSITENVALEALTMDADASLNDEDFLPDDVVQY
LNSQNQTGYGQQLQSSISEDGKVAREPEDLDLPGLPDSHVGQQYPALEQPCSEGSKTDLP
IQWNEVSSGSSDLSSSKLKCGQRPTVQQARGFGLYSNMVVHPQNLWKVGTGPAGGSQTLG
ENGSSYSDPEHFAVHSGDGLGPSGDTFHEQAYKTQQYGSQLSRQPLTSSVLDSACGAGIQ
GSKLKGNSLQENGGLLDFGLSMAPNELADNIVNGIQTQEQMGQGYIAPQLLSGSMQHQGP
SRPGQQVLGQVGATSHINIYQGTESCLPGTQDKISQPSSMAVIRGYQPCASYGGSRRQAM
PRGSLTLQQGQLSDVSQTSRVNSIKMEAHGQSHQLCSSMQNYSGQFYDQTMGFSQQDRKA
GSFSLSEANCLLQENGSENSELLSPGVNQVTSTVDSFESHDLEGVQIDFDAIIDDGDHTS
LMSGALSPSIIQNLSHSSSRLTTPRASLPFPSLSMSTTNMAIGDMSSLLTSLAEESKFLA
VMQ
>Gasterosteus aculeatus GLI3
PGLAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYINPYMDYIRSLHSSPSISVLSA
TRGLSPADVISSSFLQKRLLYSAPHTGLTTAEYYHQMALLAGHRSPYATDLLPSVASTAG
ATSATALHMEYLQAMENSRFSSPRLPSRPSRKRPLPISPLSDHSFDLQTRIRHSPNSLVT
MLNNSRSSSSTSGSYGHLSAGAISPALSFAYPSTPVALHMHQQLLGRQPGMVGSAFGHSP
PLIHPSPAYATQRPVPGIPPSGLSASERSALSSDSAQTKPTSESAVSSTGDPMHHKRSKM
KPEEELPSPGAVSVQSLGRRGGNCFCFCLIKIDHPDGMTLVKEEGDKDESKQEPEVVYET
NCHWENCCREFDTQEQLVQHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRH
TGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT
HSNEKPYVCKIQGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDLPLGGYTDQREYNHA
TSKQDECLQVKSIKTEKPMTSQPSPGGQSTCSSDQSPVSHYPCSGVQLAVSAGRSLGEGH
CVGERAPIMDSTVSTATAAMLTLQARRSVGRPLRWMEHMKMERLKQVNGALPRLGPLSPT
PPPKGSTLPNILGKENSNITTDLCLNPAVRNKLSPDSIFPVWLLERSGVKTDVVWVLISS
YCVKLNSSGISPCFSSRRSSQASQSEGTAAAAHHHRRLHNLSSSDSYDPISTDASRRSSE
ASHGSRGMLTLTPAQHYHLKAKYAAATGGPPPTPLPNMERMSLKTRMAMMDEGGSNQSLP
PLVRPHCCGDGANGYANGYAGHAGHRRRVLYPGEGPLNGNRRASDPVRTQAGDMGSLPPV
QRFNSLNNLHPLPPLSHHSTPEARSFSLQSYTRSEGNLQRGLQHSPYTPSIAEHAALEAL
AMEDEAGLLLGDEDMLPDDLVQYLHSQAQVDGGSYMHIEEQIASSQRDASHPPMEEMGQI
QAAGLDMGHAGSHGLLQQQQQTAERTSPSKLPIQWNEVSSGSADRSPQREQIHRAQCGRW
PAAEHGPVPFGRFGNMVVQQQVPLDFQNSCVQANQSQGACFVNPAVKLETPPNSCMEMRG
FGRPNFAQIIDGPLQQGFKHPPPGGPPKQSHFQQNHSQMGSNLILSRSSVDILPSVSQGA
AAHHNRQIHVPRPPDGYRNSARIQQYLNAETSGESQAGLNKQQQLQRSGDHCSLAHQVSG
LKLEASDHGYLEQGFGDCLSYAPLDCKASPFPVLEDQCLLNSMVESAGQVVGGGGGGGNS
AALLSPGTDQVTSTMEGAVPGILDDGVGLDFGAMLEDGYDQGSLVSGVLSPSIFQGLSRT
SSRLTTPRASAAFHSVAPGLNNMAIGDMSSLLTTLAEESKFLAILQ
>Tetraodon nigroviridis GLI3
EDDSSGTPFHRERRNAISSHAPTPGGLDRSISEEPSTSTEERPSLLKKELHGSLAHLGDH
ALPYRGTLFAMDPRNGYLDSHYLRATLRCRQPVSAGGFLVCLLPKWHPHRYVSAAPQFFP
TFHPPVPIDDRHTQGRYIYEPSPVPPLHVFWYPASHRERIRPLSAPRDEGHFFILLSNCP
KRIRWNFGGRRPPALAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYISPYMDYIRSL
HSSPSISVLSATRGLSPADAPHTGLTTAEYYHQMALLAGHRSPYAADLLPSLAATAGASG
AAASHVEYLHAMESSRFSSPRLPSRPSRKRPLPISPLSEPSFDLQTMIRNSPNSLVNILN
NSRSSSSTSGSYGHLSAGAISPALSFAYPPTPVALHVHQQLMGRQPSIVGSAFGHSPPLI
HPSPAFTTQRPVPGIPASGISASERSAISSDSSQTKPTSESAVSSTGDPMHHKRSKMKPE
EELPSPGAVSIQDHPDGMTLVKEEGDKDENKQEPEVVYETNCHWENCCREFDTQEQLVQV
RHKRQVQRRLVGDVGGAALSLFSDEELALHAEAAAHINNDHIHGEKKEFVCRWEDCSREQ
KPFKAQYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCN
KAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRG
DYPRPPPQPREPGSNGQGRSPGQLPLGGYTDQREYTHSTSKPEECLQVKSIKTEKPMTSQ
PSPGGQSTCSSDQSPVSTHPYGRVQLAVSAGRSPGEGLEESEEKEENEEADEECEEGEQA
PIMDSTVSTASTAMLALQARRSVGRSLRWMEHVKMERLKQVNEALPRLGPLSPTPPPKVS
TLPTILGKGSCLGRQWGVTAPQPPAHGELGSTELTVLNLLRDRRDSSGSATSSAYLSSSR
RSSGISPCFSSRRSSQASQNEATMAAVYHRRLHNLSSTDSYDPISTDASRRSSEASHCGG
GGGGMLSAGGCGGAFGLGVGGGGGSRGMLSLTPAQHYHLKAKYAAATGGPPPTPLPNMER
MMGDALVRPHRCADGSPGSVNGHTGHSGYRRRVLYPGEGSANRNRRASDPVRSQAPDACS
LPPVQRFSSLNNLHPLPPLSHHSIPENCSLSLQNSARSEGNMQRILQHSAYNPSIAEHAA
LEALAMEEDGGAGLLLGDEDMLPDDLVQYLHSQVQSDSCAFMNVEEQLASSQRDPSYPSM
EELEQIQSSGLDMSYSGSHGLQQQIAERRSPSSLPIQWNEVSSGSADRS
>Takifugu rubripes GLI3
METQSQASSAAEKKKKVETIAATKGLVARNDISEKAVASSTTSNEDDSSGTPFHRERRNA
ISSHAPTASGLDRSISEEPSTSTDDRPSLLKKEQHSSLPHLADHALPYRGTLFAMDPRNG
YLDSHYAAPQFFPTFHPPVPIDDRHTQGRYIYDPSPVPPLHVPPALAGSPAFSDISLIRI
SPQRNPSVGAESPFHPPHPYISPYMDYIRSLHSSPSISVLSATRGLSPADAPHAGLTTAE
YYHQMALLAGHRSPYATDLLPSLAATASASGAVAPHVEYLHAMESSRFSSPRLPSRPSRK
RPLPISPLSEHSFDLQTMIRNSPNSLVNILNNSRSSSSTSGSYGHLSAGAISPALSFAYP
PTPVALHVHQQLIGRQPSIVGSAFGHSPPLIHPSPAFATQRPVPGIPPPGISASERSAIS
SDSSQNKPTSESAVSSTGDPMHHKRSKLKPEEELPSPGAVSIQDHPDGMTLVKEEGDKDE
SKQEPEVVYETNCHWENCCREFDTQEQLVQHINNDHIHGEKKEFVCRWEDCSREQKPFKA
QYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSN
ASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDYPRP
PPQPREPGTNGQGRSPGQLPLGGYTDQREYNHSTSKQEECLQVKSIKTEKPMTSQPSPGG
QSTCSSDQSPVSTYPYSRVQLAPIMDSTVSTASTAMLTLQARRGVGRPLRWMEHVKMERL
KQVNEALPRLGPLSPTPPPKVATLPNILGKGSCLGRQWGVTAPQPPINGELGSTELTVLN
LLRDRRDSSGSAASSAYLSSSRRSSGISPCFSSRRSSQASQNEATTAAAHHRRLHNLSST
DSYDPISTDASRRSSEASHCGGGAGGGGGGPLSGGCGGVFGLGVGGGGGSRGMLSLTPAQ
HYHLKAKYAAATGGPPPTPLPSMERVMDDGGSNQTLPPLVRPHRCSESSWGNTGGYVGHS
GSRRRVLYPGEGALNRNRRASDPVRTQAPDACGLPPVQRFSSLNNLHPLPPLAHHSIPEN
CSLSLQSSTRSEGNMQRFLQHSTYNPSIAEHAALEALAMEEDGGSGFLLGDEDMLPDDLV
QYLHSQVQSDSLSLLNIEDQLASSQRDTSYPSMEEFEQIQSSGLDMSYPGSHSLQHQIAE
QKSPSSLPIQWNEVSSGSADKSPHRKQNQQTAYGRWTGSGNGCASAPFGRFQNMVVQQQV
PLEFQNNCPNASQPQGACSVNPAVKLETLPNSCMELRGTRGTFGRSTFPQGLDGPLPQVF
KQQPANGAPRQSHSQLKHHSTTPSQDGADPGSSLNNLSGLSHGAALSLHRQVHVPHPPNS
YRTFARAQQGHNSSNMLTNTKQQLMRRNGDHCSLAHQVSGLKLEAPDQGYSESGYGQSLS
YGEGDCKASSFLALKDQCLLGSITEPLGQSEGINGTAPVALLSPGADQVTSTVDSLGPPL
DQGTSLDFGAILEDGFDQGSLGTSSRLTTPRASAAFHSVAPGLNNMAIGDMSSLLTTLAE
ESKFLAIMQ
>Danio rerio GLI3
MEPQFQTSSSTEKRMENVVGTNSAPTRTDISEKAVASSTTSNEDDSSGSPYHLERRNTIS
AQTDVVNTSGKVSEEPSTSTDERLPLVKKELQSFLHRLADHTLPYRGTLFAMDLRSGYLD
PHYTAPQFFRAFHHPVPIDDRHTQGRYIYEPSPVPSLHMPPALAASPTFSDISLIRISPH
RNPSMGTDSPFNPSHPYINPYMDYIRSLHSSPSLSMVSAARGLSPADTHHTGLTTAEYYH
QMALLVGHRSPYADLIPSVGSTTGPASSALHMEYLQAMESSRFPSPRLINRPSRKRPIPN
SPSLSDPSFDLQAMIRTSPNSLVTILNNSRSSSSNSGSYGHLSAGTISPALSFAYPPTPV
ALQMHQQLISRQPGIVGSAFGHSPPLMHSALAFSTQRPVPAIQTSSLAPTERSIVSNDSQ
SKPTSESAVSSTGDPMNHKRSKLKPEEEPPSPRAVSMQEQMNGMTLVKEEGDKEEGKQEP
EVVYETNCHWDGCCREFDTQEQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLV
VHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRA
KHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGETYPRPPPQP
REPGATTDQKEYTHATSKQDECLQVKSIKTEKPMTSQSSPGSQSSCSSDQSINGPHVSQG
VQLTVNSIGLAGEVAMLEDMENEEEDEENREGEKEDAPIMDSTVSTATSSAATIVLQTHR
SVGRPLRWMEHVKMERLRQVNGAVPRLGFLPPTPPRKGQAMPALTGKGQCLGRMTSVRVP
PCPEPSNTELTILSLLHERRDSSGSNTSSAYLSSSRRSSGISPCFSSRCSSQASLSEYSP
HRHIHNLSATDSYDPISTDASRRSSEASQYDGGSSSAVVFGGSGVFKGSGMGSRGDLNLT
PAQHYSLKAKYAAATGGPPPTPLPSMGHINLKTHFALKEDRKDTGQLTLPPLVRSRRCSD
GAHNSHDSQAVYQRKGTYFGGGPGKNDRRASDPTHHKQNLSSYGLPQVRHFSSLNNMTSS
PNPASYGYSNREDHSLNLQNSTCHVDSFQSGLHSPCPPSIMEQSALENIFMNQDGLLLRV
NENIQSDFMQYLHSQDQESIIIQDNHRPIFNPADDQNFLSPQQQQEGVEQEDTRIDLMPI
QSNEVSSASADVTIPRQPFQRCGRWSDQSGSVSNAFGRFGNMVVQQQPIDFIDQHSALQH
MGGISYGCRNSEQHLQVAKPAQEKSRMKTGIKTESSSTFQLESKHSNFGRPDFSHIFSAP
IHQKCSQHTVVSQSYPQQNQITNQDSSNLFLQRPGNCSLLLAYRPQPAVNTSYSTRQDIN
SHNVQSCHPQSLNNRLGTSCSLSNQVSVVKLDQVNHLQINSCSTIQQQKPVFIDKCFDPE
ESKLSHAIVQSCLMESLMAEKERTSKVLLSSGVGQVTSKVERSPAEKVGLGICSIGGDSY
DQGSVVSSSRLSNSHDSFAFHSVDPGTNNMAISDMNSLLTTLAEESKFLAIIQ
>Branchiostoma floridae GLIA
MASTSPGVTKEPERRPAESSESKSDKSRHHGEAKSAETSIKKEAASSSEYAHPRLEPSRPGFPHPPLISE
HRSTYPYPSFGLDPRNGYVDPHFMSPVMPFHQPIPVDARTNEGRYTFDPHNVYHVPIHSPPFGGSPVLSD
VSMLRLTPHRPHSDPTSPLHGPHPAFRLNPFFSPYHGTPPLSALSQARGLSPHDGMTAAEYYHMAAMSQQ
RMYSDMPPLSGGSGSIAIDLPTDGSRFSTPRTAARHGRKRALSISPLSGECLDLNSMIRTSPNSLVAFIN
GGSRSGSSASTGSYGHLSASAMRTESGAESKPGTQSSANMPFSAPMPMFPYPTSPAMQQFHNRLMRQKSP
FHFGMPHASPFAAPLPAGMAMLAAQGAMPPSSSAATHTETKASLGDAFTMEPSESKRSKVKYEGSQGSPD
DVPSTTFPAESRSETSMAEGTNEDAEPPVYETNCHWDGCSKEFDTQDQLVHHINNDHIHGEKKEFVCRWS
ECTREQKPFKAQYMLVVHMRRHTGEKPHKCTEIMPQISLRTLPVLPFEGCNKAYSRLENLKTHLRSHTGE
KPYVCEHEGCNKAFSNASDRAKHQNRTHSNAKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHQTKKHK
TLGPTPRPRDPPSEKRDQDSVSSPPDSNGVHSSTTNPAASQGSPGQKPTEGHKPTGQTCDAQQSVYGSSP
HHDSGVEMNANSGSLPDLSTLDDQVISDSSISSTVPTSRASGVMVAARPGLVPRAPRIGNKPSNQRRRMR
LSSGTPGPTSPPRSDSVQLPPIEKTGSRGPSAQGSHSSVEAANRRTNELRASDLSQTSRTSSLGSLGSRK
DSASTVSSYYSSRRSSEASPFPESIFSSRRSSQASPFPGINRRTSNGSLYSPNDSYDPISLGSSRKSSDA
SSLSMNVNELGINIEQQQMLRARFIQATGRPPTAVCGNDSRPESRRGDRKEKENVEEPNPRRQSDLGHYN
RLKGTPLPKEVKDGPHRRSSAPQKNDVVTNLPDVPRDHSFNKHTPLPPVTPQPPPQIKKAFSPSKVKQAF
SPKSASTSMQGVAEEFPMDLIENEPDVIIPDEMVQFLNSQTGDDPREMVPNFEQVGTTPTFVEDIPPMQV
NPIQGDGFSNMGSPQQAFSPNRQPMPPIQQQQAFNQSQQVLSPSRQSYKMSQPMGSQPLSPMEVNMAALD
HSPNPPTYNASQMSPAQQFSPASYDPNLNSPSCRVQQNYSQMGMQSPVPNYASPTRQAQNMAPKLPNMQP
QMLSPQQRQQSQQQQLQQQMQSQQQQMQQMQKLQQMQKMQQMQKMQQMQKMQQMQKMQQMQKMQQVQKMQ
QMQQQQQQQQQAQMQNMQVQRQMQNMQKQSQLQQQMQNLQQQQRLQQQNLQQNYNMQQMQNLQSQMQLSP
NVQQQMQNLQLSPSGQQYLPEGAQQMQYQANVQFYNLQNQSGRPLENPTQVNVVHSTIEPHHSPQRPDGA
ADINLENVAMPTQNPMGFPAGNAGYTQDQSTNFVGGVNMSTPMVPPETPGSASNMVINDMSSLMASLAEE
NRYLNMMG
>Branchiostoma floridae GLIB
MASTSPGVTKEPERRPAESSESKSDKSRHHGEAKSAETSIKKEAASSSEYAHPRLEPSRPGFPHPPLISE
HRSTYPYPSFGLDPRNGYVDPHFMSPVMPFHQPIPVDARTNEGRYTFDPHNVYHVPIHSPPFGGSPVLSD
VSMLRLTPHRPHSDPTSPLHGPHPAFRLNPFFSPYHGTPPLSALSQARGLSPHDGMTAAEYYHMAAMSQQ
RMYSDMPPLSGGSGSIAIDLPTDGSRFSTPRTAARHGRKRALSISPLSGECLDLNSMIRTSPNSLVAFIN
GGSRSGSSASTGSYGHLSASAMRTESGAESKPGTQSSANMPFSAPMPMFPYPTSPAMQQFHNRLMRQKSP
FHFGMPHASPFAAPLPAGMAMLAAQGAMPPSSSAATHTETKAGEPSSSIVSSTMEPSESKRSKVKYEGSQ
GSPDDVPSTTFPAESRSETSMAEGTNEDAEPPVYETNCHWDGCSKEFDTQDQLVHHINNDHIHGEKKEFV
CRWSECTREQKPFKAQYMLVVHMRRHTGEKPHKCTEIMPQISLRTLPVLPFEGCNKAYSRLENLKTHLRS
HTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNAKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHQT
KKHKTLGPTPRPRDPPSEKRDQDSVSSPPDSNGVHSSTTNPAASQGSPGQKPTEGHKPTGQTCDAQQSVY
GSSPHHDSGVEMNANSGSLPDLSTLDDQVISDSSISSTVPTSRASGVMVAARPGLVPRAPRIGNKPSNQR
RRMRLSSGTPGPTSPPRSDSIQLPPIEKTGSRGPSAQGSHSSVEAANRRTNELRASDLSQTSRTSSLGSL
GSRKDSASTVSSYYSSRRSSEASPFPESIFSSRRSSQASPFPGINRRTSNGSLYSPNDSYDPISLGSSRK
SSDASSLSMNVNELGINIEQQQMLRARFIQATGRPPTAVCGNDSRPESRRGDRKEKENVEEPNPRRQSDL
GHYNRLKGTPLPKEVKDGPHRRSSAPQKNDVVTNLPDVPRDHSFNKHTPLPPVTPQPPPQIKKAFSPSKV
KQAFSPKSASTSMQGVAEEFPMDLIENEPDVIIPDEMVQFLNSQTGDDPREMVPNFEQVRTTPTFVEDIP
PMPVNPIQGDGFSNMGSPQQAFSPNRQPMPPIQQQQQAFNQSQQVLSPSRQSYKMSQPMGSQPLSPMEVS
MAALDHSPNPPTYNASQMSPAQQFSPASYDPNLNSPSCRVQQNYSQMGMQSPVPNYASPTRQAQNMAPKL
PNMQPQMMSPQQRQQSQQQQLQQQMQSMQSQQQQMQQMQKLQQMQKMQQMQKMQQMQKMQQMQKMQQMQK
MQQVQKMQQLQQQQQQQAQMQNMQVQRQMQNMQKQSQLQQQMQNLQQQQRLQQQNLQQNYNMQQMQNLQS
QMQLSPNVQQQMQNLQLSPSGQQYLPEGAQQMQYQANVQFYNMQNQSGRPLENPTQVNVVHSTIEPHHSP
QRPDGAADINLENVALPTQNPMGFPAGNAGYTQDQSTNFVGGVNMSTPMVPPETPGSASNMVINDMSSLM
ASLAEENRYLNMMG
>Ciona savignyi GLI
METAGKNDIDVLHQKCGKDFSREEKATPQTHLPPDHKIEGSEHHSRRSEAPKPGKQSAFF
SSQDENEAREEAVVSSSTSPSDKRTKRSSSPDHNEHLRQQNDELRHQSRHQSVREAATST
TTFEDEFEKQFHGNENLGVTSSDGRPPSCGTPLGKIKEETSSNNRKVMLLGNAHQFTKPS
PSNRNMTSSQAGNTNCNGEDRRYPIGNPHTQVDPHSRDGRYPFEPRTMNNAPGFSGSPIH
SDISLIPMSPQQSANPFNYNSSLEFYMGGLSQGGLRSPTMSILSQARNLSPHHSIQELEK
LCYPYYNAHQSNMSVNGAQQNSNQSLPGNFSQNINPLAYYQLMQQQQRLLAVAARNDRNL
ALSLEKQEDFGRFPSPLCRSRARKRPLSISPCFSDTGLDITAMIRTSPNSLLPFGGLTNS
RSSSVASGGSYGHLAAGGISPTFGYQTPMMTSPQHLHAHLLSRQMQSSFAGQLMPGFPTN
QGAFDKPNSRFDPNISTRNYLPHVGASAASNDMCNPHRDNKNFSKHSVDPQSPNVQFNNN
NNNSNSIPGISPGGHGANEENDVVYDTNCSWVNCSLEFDTQEQLVHHINNDHIHGDKKEF
VCRWIGCARDQRPFKAQYMLVVHMRRHTGEKPHRCTFEGCSKAYSRLENLKTHLRSHTGE
KPYVCEYPSCTKAFSNASDRAKHQNRTHSNEKPYACKQAGCTKRYTDPSSLRKHVKTVHG
PEAHVTKRMKAEREREGKREPNIKQEPGMDKDKRKGDAGGTKRTCHPLSPGSNPPSNDQN
PPSNMNPRSNQSSCTSGSDVSVTPQNSPHMTSQNNDSGVDVNVGANEGDSDGDIVVDENP
QPDSTSGGVGVQSRHRGTVRASLVPRLVNKKMQNLSIGGNIESYVDIGGYDDQRKLGMHK
AESFTEVSSTTAFPAKQKNATFPRKLPLTPHRQVALLNQDRRDSGTVSDGSRKSSLASQN
SRRSSQNTGGINVAGSYDPISLDSSRRSSSNVTSGSSALNPYQLHRLRSRFNENAGLPPP
TPVDREGYTKSQLSRWLKDDTPIPDRGGYLYNPQQRPSLPQMGPPKPPMEDRRRSEPRSS
ARTPLPPHLGGGVAFRRASDPTRKSPQMDPTRLPNVQRHNSWNSIHPLPGIKPQGCAYPG
AVPCNPSNQPPMQQVQRQRSISNSSNYYGGESGYHSHGSNMALHQPSYQVNEQVLMENFN
NDVINGDVTYNGQVYGKSDHWHQQTTPHPHQTMTPASVGSMPPHQRFPQNGHINQNPFPR
SFNNNPNVGPNKGVQDANATRYYGNPHFNPNAQMGGQVHGHPTMRPQKMTQQNVTQQFGN
PDFMQLPYNAPSPYIAQRQSVQNQGRSPNMINSGNVEMHLGHQNRTANQITPRPPVSSTS
SNQNRMRLQRVRQSGSSSVTSYNQAPSVTSQSNGQAGRTNYTPDAQIPDEFLQQEFIDSI
PELHPETHRENEPNENQPYVKMAADSTTGPDLDGITGNFCYQDDDAMSGTNTDVTLPPMS
AFSSRMATPMMGKYPPQIPTNQHPASNMAINSMSSMLSTLEEENKYLNLLPQ
>Strongylocentrotus purpuratus (XP_001195249)
MSSVSKQVTEPNNNQVTSSVDLDNHQSKGMDDPNTVSSTSHMEGSPSAPAPGGDHRDDDGAHGGEEDIPV
VTDCEWDDCHRKFDTLDQLVQYDNHLFFFLLKFVCNLLQHINNDHIHNERKEFICHWRDCIREEKPFKAQ
YMLVVHMRRHTGEKPHKCSFEGCYKAYSRLENLKTHLRSHTGERPYVCEFQGCTKAFSNASDRAKHQNRT
HSNAKPYACKITGCTKRYTDPSSLRKHVKTVHGPEAHVTKRQRGDKRDPPSGSGGEKEGRKGDDMDKKSP
GDVKPITKAISVSSNSTNNNRTKGVPQECHTSAHQSVHLSAPVNDYSSSPHNDSGVEMNATGGSIGDLTS
IDDEKLIQDDQISSNVGDLGDGIGHRGRMGRRGGGGGRGSLTVTTAPTIIGRTTSPFMERSIKIKAGMSR
PTHKAKTGVHILPQMPPPPPPPLQQQLPPVINNNNHGIDYKPKARNIEKLIFEERCDSSQSMTGNLDNLG
NRRGSDHSTVSSYFSGRSSEASPFFMGSQFSSRRSSQASSYMSSMSSRRTSGASQWSGHMGMNSPYDPIS
IGSSRRSSEASSLNGPTGLPGLTLAQQRSLQARYEQTIMQQNSGDERFGMTPSPMPPPGYRRLSGVASMP
PHPPRTPLPNEIPGNEIRRGSEPISSNQNSHMNRRYSSFNNKQPLPLPENMKNFRPAFHNIHHPPTIHEQ
DGGSGREQWQNIPQNHYEHGTIPEESMDTGGSGGPEEFMFPDEMVQFLDDQCKQEMQWTGQRQMPAGGGG
GDGGRGFNQPHGNNHPGHNQMQGGYNMQPLNSDALDHVQQIVPETMESETENKMPYNSQGASAGYPQQEN
VVNPTISNMAVTDMSSMLTSLAEENRFLSIM
>Drosophila melanogaster (Ci)
MDAYALPTYFPLAYSELQFLASRRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPSIIP
TGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYRIPGYME
QLYSLQRTNSASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSSLGELHNAAVAAAAAG
SLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSDSFDINSMIRFSPNSLA
TIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPMTPQQVAA
SGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKK
GPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYIN
CGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTN
KKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRS
HTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVK
TVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPS
IKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAM
VNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITE
LKMEPGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQN
STASTYYGSMQSRRSSQSSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANC
NSFTSTSGLPVLNKESNKSLNACINKPNIGVQGVGIYNSSLPPPPSSHLIATNLKRLQRK
DSEYHNFTSGRFSVPSYMHSLHIKNNKPVGENEFDKAIASNARRQTDPVPNINLDPLTNI
SRFSTTPHSFDINVGKTNNIASSINKDNLRKDLFTVSIKADMAMTSDQHPNERINLDEVE
ELILPDEMLQYLNLVKDDTNHLEKEHQAVPVGSNVSETIASNHYREQSNIYYTNKQILTP
PSNVDIQPNTTKFTVQDKFAMTAVGGSFSQRELSTLAVPNEHGHAKCESFHHQSQKYMNT
DIGSKQQSALPSAHQRQTEKSNYNQIIDSSMTSLPELNVDSIYPRNETENIFKVHGDHDN
EIQCGIISQSQMSPSTNLNNDGQFSTVNMQPITTSKLFPPEPQKIVCDTQASNTSVMHLD
TYQRTLEYVQSCQNWMETNNTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMT
TSLTSLLEENRYLQMMQ
>Apis mellifera(XP_624136)
LSSSTTAIGTAATGGGGGASSGASGGGGGGSGGGGGGAAGNGTSGGDFLRRSHPLSEHTA
LHPAYRLNYMDHLYHQLQASTHSPNASLHGLGGLGPEYLLHAAGPASTLASSEFPFSIDV
SASSRLGSPRASAIRASRKRALSSSPYSDRFDIDSMIRFSPNSLASIVNGSRSSSASGSY
GHLSAAMSPALGMHPGMAPHLQQLQAHLLRSAAAAALLPHAHPLQRPAPPPPPPHPHPHA
HGLSPHSQLYPGVPPHSTASATLGPHGGGLPPKTESAESCRKASESTTRSVTAEADTSSR
RTSTKVKREPATTTTNATTTTAPPTHPQGLSPSEDLRDEPGDFIETNCHWRDCGLEFPTQ
DDLVKHINNDHIHANKKSFVCGWEECSREEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCF
KAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYVCKAPGC
TKRYTDPSSLRKHVKTVHGAEFYANKKHKGGGGDGGGSDEAGAGGHSPSRSEDLHPKTPS
LSSPSVKSESEANSPPSMMQQQGSPLVGGCNDEVAGVGTLTGDGVALAEEPWNEEPDDLD
IADLPVALRAMVGGMESQQQQQPPPPASRNRLKGRLNAKGMPNLPVSVSSMRGTRGMGPQ
GNIGDLNRRITDLKMEGGGSARQTSLSDLQLRLQPLSEPRRDSNSTVSTYYGSMKSTDFG
SRRSSQASGVSAVRMGQTGPGSFYDPISPGTSRRSSQMSTTSGRMNPPNLQGPYSTSNLV
VQTQNMSLQGIQGIPGDWNGPSGHCTQLSGDRRMSEPTRGHQTQRNSPPVPPRPRSAQLP
EHHPNQEVILDEVGEGEMVENKLVIPDEMMQYLNQVQAGGTQVNCRSPLPICQSPICTNP
LHYQRQIQPTCNYNQSHQQTCYPSSQSAQPCTNYQNTSPSPYNQCPSSRPPQSNSQYCPP
PTYPLQPNGGQVLSPAAGQVMSPGSHYAPSHISDQPLTSPAAGALAPQHPPQNLPQNSAQ
LTRNCPQNHMHHGYYPNYNCQGQMNANCTGNPNGQVNHHTNSTCAPPNHNTMTQQQCVQM
RSAGNCQQLSSHCTQQPVIPNQTTMSHPNTQCGQVANQCTRPIVTPNGQMPNLHSVQQTT
VPNQCAQMSPHCSQLNMNNQAKPITNMTNLQGCQQQVQQPTTPCLQMANCAHPNSGHRPI
TDNTLSKRTSPQLCSAQQTNCRMQQQQHTCTHNCQARTNPPNHQYNCNCQWGYDQCYHEQ
TGTAMPEIQCRDISQSQQGSPIKPPQGMRQDSYRRTLEYVQQCRNWSGNAQTHETNVSSS
THPISLPQPLPSSANMVVNDMTSSLSSLLEENRYLQMIQ
>Caenorhabditis elegans (Tra)
MAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDP
SKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSD
ELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPPG
TFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEH
HAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHT
GEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKAV
HGDDEYEKAKKSRPANYSNRRRPDHRLAPPTGAMSHPYLATPNSGASVVAHSSVHQQNFI
NMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQAQAQMLQTHMMQQAQI
QAAAQMQAQVQHQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQT
PPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAPVPASPVFDELREQMREVEPLQQQ
QQQEPMDQDLQDIRVDGDSDDEDEEEPRTPSGALLLPRGGNNGDGGFGGSGSSRASSGSG
TMELSAAPISQNGSRASGSGERGMRSFLIADILQLAADFQNERLLSDVLDLAIFDTRDVR
SLHNIYQVYIRAHKAIPITRRPLDWNETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFWR
TIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFEDEDDV
PGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDHY
YPPMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTKTLLI
QRALFDKTSSVRRSLLQFITISVDQEELRQSCHATSAPQGAHVVHNVVDEFDSIMRAQED
SNNRILLSLDIPAPSAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPPP
PPPAPPRRRRSADNKDDSENIPKKPRHQF