>Homo sapiens_ADAMTS1(ENST_284984)
MQRAVPEGFGRRKLGSDMGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEEL
VVPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDL
AHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAP
LQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG
QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN
SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD
LCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASL
NGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGT
SYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWC
INGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEG
KRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKL
ICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGN
GSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILN
GDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTY
FVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPAS
TRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDF
CTMAECS

>Mus musculus_ADAMTS1(ENSMUSP_23610)
MQPKVPLGSRKQKPCSDMGDVQRAARSRGSLSAHMLLLLLASITMLLCARGAHGRPTEED
EELVLPSLERAPGHDSTTTRLRLDAFGQQLHLKLQPDSGFLAPGFTLQTVGRSPGSEAQH
LDPTGDLAHCFYSGTVNGDPGSAAALSLCEGVRGAFYLQGEEFFIQPAPGVATERLAPAV
PEEESSARPQFHILRRRRRGSGGAKCGVMDDETLPTSDSRPESQNTRNQWPVRDPTPQDA
GKPSGPGSIRKKRFVSSPRYVETMLVADQSMADFHGSGLKHYLLTLFSVAARFYKHPSIR
NSISLVVVKILVIYEEQKGPEVTSNAALTLRNFCSWQKQHNSPSDRDPEHYDTAILFTRQ
DLCGSHTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKHCAS
LNGVSGDSHLMASMLSSLDHSQPWSPCSAYMVTSFLDNGHGECLMDKPQNPIKLPSDLPG
TLYDANRQCQFTFGEESKHCPDAASTCTTLWCTGTSGGLLVCQTKHFPWADGTSCGEGKW
CVSGKCVNKTDMKHFATPVHGSWGPWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCE
GKRVRYRSCNIEDCPDNNGKTFREEQCEAHNEFSKASFGNEPTVEWTPKYAGVSPKDRCK
LTCEAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGG
NGSTCKKMSGIVTSTRPGYHDIVTIPAGATNIEVKHRNQRGSRNNGSFLAIRAADGTYIL
NGNFTLSTLEQDLTYKGTVLRYSGSSAALERIRSFSPLKEPLTIQVLMVGHALRPKIKFT
YFMKKKTESFNAIPTFSEWVIEEWGECSKTCGSGWQRRVVQCRDINGHPASECAKEVKPA
STRPCADLPCPHWQVGDWSPCSKTCGKGYKKRTLKCVSHDGGVLSNESCDPLKKPKHYID
FCTLTQCS

>Dasypus novemcinctus_ADAMTS1(ENSDNOP_15134)
MEAARRPRSSQRALSRLLLAVAAVLLTVPGTGGRPAQEDEELVLPELQRAGEHETTRLLL
DAFGRRLLLELQPDHGFLAPGFTLQTVGRSPEPETPRPESSGDLAHCFYSGTVNGDAHSA
AALSLCEGVRGAFYLQGEEYFIQPAPAAASVRLAPAAHGEEPPQQPQFHLLRRRRRGGDG
AKCGVMDDEILPPRGAGPEDGTGEQWSQRDRAPQSAEQPTGTGSIRKKRFVSSPRYVETM
LVADQSMADFHGGGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIYEEQKGPEVTS
NAALTLRNFCNWQKQHNPLSDRDAEHYDTAILFTRQDLCGAQTCDTLGMADVGTVCDPSR
SCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASINGMNRDSHLMASMLSNLDRSQPW
SPCSASMITSFLDNGHGECLMDKPQNPIQLPSDLPGTLYDANRQCQFTFGEESKHCPDTA
STCTILWCTGISGGLQVCQTKHFPWADGTTCGEGKWCVGGNCVNKTDRKHFDIPVHGSWG
PWGPWGDCSRTCGGGIQYTMRECDNPVPKNGGKYCEGKRVRYRSCNIEDCPDNNGKTFRE
EQCEAHNDFSKASFGTGPAVEWTPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPC
SPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGICGGNGSTCKKISGSVTSAKPGYHDVIT
IPTGATNIEVKHRNQRGSRNNGSFLAIRAADGTYILNGDFTLSTLEQDITYKGSVLRYSG
SSAALERIRSFSPLQEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSEWVIEEW
GECSKSCGSGWQRRLVECRDINGQPASECAKEVKPASTRPCAEGPCPHWQLGDWSPCSKT
CGKGYRKRTSKCVSHEGAVLSQESCDLLKKPKHYIDFCTMAECS

>Gallus gallus_ADAMTS1(ENSGALP_25419)
IRNWKLPFICSQYCGRKMYXQRPAARQALVLPRRLGSAGGRERFRLEAFGERLTLELEPD
SSFLAPDFTLQYLGGPPPPSSSSPPPGDDLARCFYSGTVNRDPGSAAALSLCAGMRGAFS
LRGREYLIQPAPGAAAHRLGPHLLRVRGPRAPAASRCAVTEQGEKRGRGGGARAGAGALG
AQTRSKRKKRFVSSPRYVETMLVADQSMAEFHGSGLKHYLLTLLSVAAKLYKHPSIRNSI
SLVVVKIMVIYEERKGPDISSNAALTLRNFCSWQKQHNPPSDRHAEHYDTAILFTRQDLC
GAKTCDTLGMADVGTVCDLNRSCSIIEDDGLQAAFTTAHELGHVFNMPHDDAKQCAGING
ISRDFHMMASMLSNLDRSQPWSPCSAYMITTFLDNGHGECLLDKPHRPIQLPSDLPGTLY
DANRQCQFTFGDESKHCPDAASTCTTLWCTGTSGGLLVCQTKHFPWADGTSCGEGKWCMN
GKCVNKTEKKHYDTPVHGSWGSWGAWGECSRSCGGGVQYSFRECDNPVPRNGGKYCEGKR
VQYRSCNIEDCPDNNGKTFREEQCEKHNEFSKSTFGSGPAVEWTPKYAGVSPKDRCKLVC
RAKGTGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRMIGSNKKFDKCGICGGNGS
TCKKVSGTFVRAKPGYHDVVTIPAGATNIEVKQRNHRGARHDGSFLAIKAADGTYVLNGD
YTLSTLEQDITYKGSVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGDLPQPKIKFTYFV
KKPAQPASEKVPSKKKESFNAIKEIISSEWVIEEWGECSKSCGSGWQRRAVECRDPRGRP
ATDCARELKPSDIRPCADIPCPQWQLGDWSACSKTCGKGFKKRLLKCISYDGGVLPQESC
EPSKKPKHLIDFCNVTDCS

>Xenopus tropicalis_ADAMTS1(ENSXETP_29862)
AKMMGYLLPWMAALLCARNALGMGTALEEELVAPVRLDPGTTQGESGNGKVRYHLNVFGE
SLTLDLEPDRTFLAPDFSLQYVGSPAERNGGAEPLAELAKCFYSGSVNGDSTSSAALSLC
SGLRGAFFYRGEEYLIQPSNHTLTVADPDSPDPLVLHLVRRRSRAKAKCGVTDSVGQPVK
SEDAPSQRTMPPTEKKATKKRSGSSRRKKRFVSSPRYVETMLVADQSMAEFHGSSLKHYL
LTLMSVAAKLYKHPSIRNSISIVVVKILVIYDEQKGPDVSSNAALTLRNFCSWQKQHNPP
SDRHAEHYDTAILFTRQDLCGAQTCDTLGMADVGTICDPTRSCSIIEDDGLQAAFTTAHE
LGHVFNMPHDEAKQCSGLNRDNQDSHMMASMLSNLDRYEPWSPCSAYMITSFLDNGHGEC
LLDKPHRPIQLPSDLPGTLYDANKQCQFTFGDESRHCPDAASTCTTLWCTGVSGGLLVCQ
TKHFPWADGTSCGEGKWCINGKCMDQTDKKHYETPVHGGWGAWGQWGECSRTCDGGVQYS
VRECDNPVPKNGGKYCEGKRVQYRSCNIQDCPENNGKTYREEQCEAHNDLSKSPFGSGPA
VEWTPKYAGVSPKDRCKLMCRAKGTGYFFVLNPKVVDGTPCSPDSTSMCIQGQCVKAGCD
RVIGSSKKFDKCGVCGGNGSTCKKVSGNFIISRPGYQDVVTIPAGATNIEVKQRNNRGSR
HDGSFLAIKAADGNYILNGDYTLSTLEQDIIHNGNILRYSGSSASLERIRSFSPLKEPIT
IQVLTVGDSHRLKIKYVYFVKKTGQPEKPNKKKESFNAIRETILSEWVIEEWGECSKTCG
LGWQRRTVECKDINGQPSTDCANELKPDDIRPCADTPCPQWQLGDWSSCSKTCGKGFKKR
LLKCVSYDGVSMPQENCDPLKKPKHLIDFCTLANCS

>Danio rerio_ADAMTS1(ENSDARP_60938)
MSFLRVVLSLAGFALCVNAAQSAWEESFVLPVRLDTQPGHTKQSREEDSEKRIYRLDVFG
KRMVLALEPDQTFLAPGFVFQMVGKPETGEFDSAGEARCFFSGTVNGDELSSAAINLCKG
LHGGFSVGGEEYFIQPENSTGAATDRDTHTIRRRTPGILAEESGSKCGVNEEEERVTEKP
HTTHSKPSESKAHHRSRRFVSTPRYLEIMIVADQSMAEFHGAQLKPYLLTIMAVASRLYR
HPTIHNSITLAVVKLLVVHDEEHGPHVSTNAALTLRSFCQWQKQHNQPSDRHPEHYDTAV
LFTRKDLCGAHSCDTLGMADVGTACDPDRSCSIIEDDGLQAAFTVAHELGHVFNMPHDDA
KQCASVNGDQWGAHMMASTLSNLNQLDPWSPCSALMVTSFLDNGHGQCLLDKPQKPEELP
QTLPGSVYDADRQCRLTFGEESQHCPDLSSTCAALWCTVTSANGLLVCQTKNFPWADGTP
CGSNSYCMAGQCLSKTEAAKYETPVNGGWGSWGSWGDCSRTCGGGVQYSFRDCVNPRPKN
GGKYCEGKRIQYRSCNTETCPDSNGLTFREEQCLAHNDLSSQVSLGSGEGVEWVPKYAGV
SPKDRCKLVCRAKGTGYFFILKPKVADGTPCTPDSTSVCVQGQCVKAGCDRVIGSDKRFD
KCGICGGDGSTCKKVSGSMERARPGYQDVVTIPAGATHLDVKQRSFGGRSQDNSYLAVRR
QDGSYLLNGDYKLTTLETDISVKGALLRYSGSSVLLERLRSFAPLPEPLTIQVLSVGESP
RPRVKYSYFAPRPNGSNRPSINAISKAVDAEWFLGEWGTCSKTCGGGIQTRDVMCLDSKR
RPSKNCVDELRPASSRQCALQDCPFWFLGEWGTCSKTCGGGIQTRDVMCLDHNRRPSKDC
VELHPPSSRQCALQDCPAWFLGEWGTCSKTCGGGIQKRDVMCLDHNHRPSEDCVELRPAS
SRQCALQDCPFWLPGNWSECSRTCGRGFRKRTLSCITHDGHILPNSSCNATDRPRPLLNL
CNLTPC

>Takifugu rubripes_ADAMTS1(ENSTRUP_27148)
MLLLHIFLGIIASLCVGTAHGAWEESMVVPVRLDPATRPEPWRTFSVEEQQKRAEMREYR
LEVFGKELVLELEPDQTFLAPGFVFHIVGSPESEPTPESKNGAEPGCFYSGTVNGEEHSA
AALNLCHGLRGGFYFQGVEYFIQPLNSSDFVGTEETVHMIRRRARASLAEEGSSKCGVNE
DEERVPKNLEKEAGRGAANGDQTAHHRTRRFVSTPRYLEIMIVADQSMAEFHGAGLKPYL
LTIMAVASRLYRHPSIHNSISLAVVKLLVVYEEEYGPQVSSNAAMTLRNFCQWQRQHNPT
SDRHAEHYDTAVLFTRTDLCGAHSCDTLGMADVGTVCDPDRSCSIIEDDGLQAAFTVAHE
LGHVFNMPHDDAQLCSEVNGAHWGSHMMASTLSNLDQQQPWSPCSALMVTTFLDNGHGQC
LLDKPVRPQALPQPLPGTVYDADHQCRLTFGEDSQHCPDLSTTCAALWCTVTTSNGLLVC
QTKNFPWADGTPCGHDSYCLAGQCLTKSQAAKHQIPVNGGWGTWGPWGDCSRTCGGGVQY
SFRSCDNPLPRNGGKYCEGKRIQYHSCNTETCPDTNAGLTFREEQCLAHNDMSAQVSLGS
GEGVEWVPKYAGISPKDRCKLVCRAKGTGYFFVLKSKVADGTPCSPDSTTVCVQGQCVKA
GCDRVIGSNRRFDKCGVCGGDGSTCKKVSGSLDRARPGYQDVVTIPAGATHVDVKQRATG
NGRHDNSYLAVRRQDGTYLLNGDYKLMTMETDVALRGALLRYSGSSATLERIRSFSPLPE
PLTIQVLSVGEAPRPRVKYSYFAPRPNNGASTSNNGGRRPSINAIREVGGAEWTLREWGP
CSQTCGGGVQQREVVCLDAYGHPSRDCPEELRPLASRSCATQPCPTWLLGDWSVCSKTCG
RGFRKRQLRCIGHDGRTLTNESCDPKDRPRPLLELCTQGAC

>Tetraodon nigroviridis_ADAMTS1(ENSTNIP_390)
MVLLRVCLAIIATLCVGAAHGAWEESVVVPVRLDPTTPTEPWRTLSVEEQQKQAERREYR
LEAFGRDLVLQLEPDQTFLAPGFVFHMVGSPDPDPTPEPKSGTEPGCFYSGTVNGEEHSA
AALNLCHGLRGGFYLQGAEYFIQPLNSSLLAGTEENVHMIRRRSRATLAEEGGSKCGVNE
DEKRVPINLEREAGGAVNGAQTVHHRTRRFVSTPRYLEIMIVADQSMAEFHGAGLKPYLL
TIMAVASRLYRHASIHNSISLAVVKLLVVYEEEHGPQVSSNAAMTLRNFCQWQRQHNPAS
DRHPEHYDTAVLFTRTDLCGAHSCDTLGMADVGTVCDPDRSCSIIEDDGLQAAFTVAHEL
GHVFNMPHDDAQMCSEVNGAHWGSHMMASTLSNLDQQQPWSPCSALMVTTFLDNGHGQCL
LDKPVRPQALPQPLPGSVYDADHQCRLTFGEDSQHCSDPNTTCAALWCTVTTPNGLLVCQ
TKNFPWADGTPCGHDSSCLAGQCLTRSQAAKHQIPVNGGWGLWGPWGDCSRTCGGGVQYS
FRSCDNPLPRNGGKYCEGKRIQYRSCNTETCPDTNGLTFREEQCLAHNDMSAQVSLGSGE
GVEWVPKYAGISPKDRCKLVCRAKGTGYFFVLKSKVADGTPCSPDSTTVCVQGQCVKAGC
DRIIGSNRRFDKCGVCGGDGSTCKKVSGSLVRARPGYQDVVTIPAGATHVDVKQRAAGNG
RHDNSYLAVRRQDGTYLLNGDYKLMTMETDIALRGALLRYSGSSTTLERIRSFSPLPEPL
TIQVLSVGEAPRPRVKYSYFAPRPNNGASTSNNGGRRQSINAITEVGGAEWTL

>Gasterosteus aculeatus_ADAMTS1(ENSGACP_19888)
LDVFGKELVLQLEPDQTFLAPGFVFHIVGSPDTDPTQEPKSGAEPGCFFSGTVNGEEHSA
AALNLCHGLRGGFYFQGAEYFIQPQNSINFTGTEKDVHVIRRRDRAVLAEEGSSKCGVNE
DEEKVPKNLEKEDQHGAANADQTDYTSVTNGNRHGKEHHRTRRFVSTPRYMEIMLVADQS
MAEFHGAGLKPYLLTIMAVASRLYRHPSIHNSISLAVVKLLVVYEEERGPQVSSNAAMTL
RNFCQWQRQHNPPSDRHPEHYDTAVLFTRTDLCGAHSCDTLGMADVGTVCDPERSCSIIE
DDGLQAAFTVAHELGHVFNMPHDDAQLCSGVNGAHWGSHMMASTLSDLDQQQPWSPCSAL
MITTFLDNGHGQCLLDKPVKPQALPQPLPGTVYDADHQCRLTFGDDSQHCTDLSTVCAAL
WCTVTTSNNLLVCQTKNFPWADGTTCGHDSYCLAGHCLSKSQAAKHQTPVNGGWGVWGPW
GDCSRTCGGGVQYSFRSCENPLPKNGGKYCEGKRIQYRSCSTDTCPETNGLSFREEQCLA
HNDMTAQVSLGSGEGVEWVPKYAGVSPKDRCKLVCRAKGTGYFFVLKSKVADGTPCSPDS
TSVCVQGQCVKAGCDRVIGSSRRFDKCAVCGGDGSTCKKVSGSLERARPGYQDVVTIPAG
ATHLDVKQRTPGNGRQDNSYLAVRRQDGTYLLNGDYKLMTMETDIALRGAMLRYSGSSAT
LERIRSFAPLPEPITIQVLSVGEAPRPRVKYSYFAPRPSNAASVSNNNGGRRHSINAIRE
VGVAEWTLREWGLCSQTCGGGTQQREVVCLDPQGRLSRDCPEELRPLASRSCATQSCPYW
LLGEWSACSKNCGRGFRKRQLRCIGHDGRTLTHESCDPKDRPKPLLELCNQTAC

>Oryzias latipes_ADAMTS1(ENSORLP_6294)
MWLLHVSIVALCVGAALCTWEESTVVPVRLEPDQREPWRTLSAEEEQKVGEMRVYQLDVF
GKQLILRLEPDQTFLAPGFVFHVVGSPESVPALAGSDSGSEPGCFFSGTVNGEAHSAAAL
NLCRGLSGGFFFEGNEYFIQPLDSSELDQVHSIRRRSRAAHKEEGSSKCGVNEDEERMPK
NPGEEASHGAPNAEQTARQRTRRFVSTPRYLEIMLVADQSMAEFHGAGLKPYLLTIMAVA
SRLYRHPSIHNSISLAVVKLLVVYEEEKGPQVSSNAAMTLRNFCQWQRQHNPTSDRHPEH
YDTAVLFTRTDLCGAKNCDTLGMADVGTVCDPERSCSIIEDDGLQAAFTVAHELGHVFNM
PHDDAQLCSGVNGPHWGSHMMASTLSNLDQQQPWSPCSALMITSFLDNGYGQCLLDKPVK
PQPLPQPLPGTVYDVNHQCRLIFGDDSKHCQEHSSTCAVLWCTVTLPSGLMVCQTKNFPW
ADGTACGTESYCLAGQCLTKSQAAKHQQTPVNGGWGLWGPWGDCSRTCGGGVQYSFRSCD
NPLPKNGGKFCEGKRIQYRSCNTETCPDTNGLSFREEQCLAHNDMSAQVSLGSGEGVEWV
PKYAGVSPKDRCKLVCRAKGTGYFFVLKPKVADGTTCSPDSTSVCVQGQCVKAGCDRIIG
SNRRFDKCGVCGGDGSTCKKVSGSLDRARPGYQDIITVPAGATHLDVKQRAPGNGRNDNS
YLAVRRQDGTYLLNGDYKLMTMETDIAMRGALLRYSGSSATLERLRSFAPLPEPLTIQVL
SVGEAPRPRVKYSYFAPRPNNGASASNNNGARRQSINAIRDVGTADWTLREWGMCSQTCG
GGIQQREVVCLDPQGRPSLDCPEELRPLASRPCASQECPTWLLGEWSGCSKTCGRGFRKR
QLSCIGHNGRTLTNDSCDSKNQPRPLLELCNQTAC

>Homo sapiens_ADAMTS2(ENST_251582)
MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV
PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL
HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG
LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS
RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE
IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH
DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG
QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ
LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA
PGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTC
SGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCE
SRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNS
HCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEEND
VDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDS
LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK
PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN
DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETA
RTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYC
SIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPL
EVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELID
EMRKKEMLGKF

>Mus musculus_ADAMTS2(ENSMUSP_40171)
MDPPAGAARRLLCPALLLLLLPPPPLLLLPPPPASVRLVAATEPPGGPPGQGAERILAVP
VRTDAQGRLVSHVVSLETAGAGVRARRAALDQTSGLPGGAAQDPGGRLFYNLTVFGRDLH
LRLRPNARLVAPGATVEWQGETGDTRVEPLLGSCLYVGDVADLPKASSVALSNCDGLAGL
IRMEEEEFFIEPLEKGQTDQEAEQGRVHVVYRRPPTPKPPPVSEPQALDTGVSQGNLDSL
SRALGVLEERINSSRRRVRRHATDDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVN
EIYHDESLGAHINVVLVRIILLSHAKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHDEY
HDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHD
GQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPFAHDWPALP
QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMC
APGKHCFKGHCIWLTPDILKRDGNWGAWTPFGSCSRTCGTGVKFRTRQCDNPHPANGGRT
CSGLAYDFQLCNPQDCPNSLADFREEQCQQWDLYFEHGDVQHHWLPHEHRDAKERCHLYC
ESKETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSRKQEDKCGVCGGDN
THCKVVKGTFTRSPRKQDYIKMFEIPAGARHLLIQEADTTSHHLSVKNLETGKFILNEEN
HLDPNSRSFIAMGVEWEYRNEDERETLQTIGPLHGTITVLVIPEGDTRISLTYKYMIHED
SLNVDDNNVLEDDAVRHEWALKKWSPCSKPCGGGSQFTKYGCRRRLDSKMVHRAFCSALA
KPKAIRRACNPQECSQPVWVTGEWEPCTQSCGRTGMQVRSVRCIQPLHNNTTRSVHTKHC
NDHRPESRRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDNFGVCREERPET
ARICRLAPCPRNGSDPSKKSYVVQWLSRPDPDSPIQKISSKDQCQGDKSMFCRMEVLSRY
CSIPSYNKLCCKSCNPPRNLSNTEDGGVEPPPGKHNDIDVFMPTLPGPTVATQVQPSPGP
PLEAPLNVSSTNATEDHPETNAVDVPYKIHGVDEEVPSPNLIPRRPSLYVKTRNQRIQEL
INAVQRKEKPGKF

>Dasypus novemcinctus_ADAMTS2(ENSDNOP_15771)
VPPASLDTLSRALGVLEERVNSSRRRVRRHTADDDYNIEVLLGVDDSVVQFHGKEHVQKY
LLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQ
KPDTDHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHET
GHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELGRYLHSYDCLRDDP
FAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKK
GPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGNWGAWTPFGSCSRTCGTGVKFRTRQCDN
PHPANGGRTCSGLAYDFQLCNPQDCPDALVDFREEQCRQWDLYFEHGNGQHHWLPHEHRD
AKERCHLYCESQETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCKKVGCDGVVGSSKQED
KCGVCGGDNSHCKVVKGMFTRSPKKQGYIKMFEIPAGARHLLIQEADSTRHYLAVKNLET
GKFILNEENDVDPNSKSFIAMGVEWEYREDDERETLQTIGPLRGAIAVLVIPEGDARISL
TYKYMIHEDSLHVDDNNVLEEYSLGYEWALKKWSPCSKPCGGGSQFTKYGCRRKLDHKLV
HRGFCKALAKPKAIRRVCNPQECSQPVWVTGEWEPCSQSCGRSGMQARSVRCIQPLHDNT
NRSVHTKYCNNARPEGRRACNRELCPGRWRAGPWSQTTLACAKGGVSKREVTCKTMSRRF
GMRRKQVSQKGREAVIGPTHREADHLKKKGYVRRWSSHPDHSYLSHFSFSEGHCQGDKSM
FCRMEVLSRYCSIPGYNKLCCKSCNLHNSTSVDDRTEPPPGKQNDIEELMPTLPVPTLVM
EVHPPPAVPLEVPLNASSTNATQDHPETNAVDVPYKIDGLDNEVQPPNLIPRRPSLFEKT
RNQRIQQLIDEMRKKRCSESS

>Gallus gallus_ADAMTS2(ENSGALP_9639)
MEPPAGFACVLLCCALCLPAAAPRRPGHRDPILRNIEEYSLVIPTSTDSEGRFLSHLVSG
PPKARFRRAADDLQHKAANEQIFYNVTVFGREFHFRLRPNSRLVAPGATVEWQEDSDETH
IEPLYGNCLYVGDITDLPNASVAISNCDGLAGMIRTDKDEFFIEPLEKGTREEEEEGGRT
HVVYRRAAAKKQLPIEDADTLYKAPNLTNLDGLDSALSLIEDGVRRSRQRHRRHATDDDY
NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKS
MSLIEIGNPSQSLENVCRWAYLQQKPDTGHAEYHDHAIFLTRQDFGPSGMQGYAPVTGMC
HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRF
HWSRCSQQELNRYLHSYDCLRDDPFEHDWPSLPQLPGIHYSMNEQCRFDFGLGYMMCTAF
RTFDPCKQLWCSHPENPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKQDGHWGA
WSKFGSCSRTCGTGVKYRTRQCDNPHPANGGRTCVGPSYEFQLCNTQDCPKDFEDFREEQ
CRQWDPYFEYQNTKHHWLPYEHVDAKERCHLYCESKETGDVVYMKRMVHDGTRCSYKDAY
SICVRGECLKVGCDRVIGSTKQEDKCGVCGGDNSHCKVVKGTFSRVPKKQGHIKMFEIPV
GARHLLIQESDATSHHLAIKNRETGRFILSEDNYVPDSKVFIDMGVEWEYRNDDNRETVQ
TMGPLRNGIVILVIPHGGAKISLTYKYMIHEDSLNVDNNNVLEEDSVSYEWALKKWSQCS
RPCGGGFQFTKYGCRRKTDHKMVHRSYCELIQKPKPIRRVCNLQECSQPIWVTGEWEPCS
KSCGKTGYQVRSVRCIQPLHDNTNRSVHTKYCNNDRPEGRRPCNRELCPAQWRIGPWSQC
SVSCGNGTQDRPVLCRTSDNAIGLCKEAKPENVKICRLPPCPRNISDPSKKTYMIQWLSR
PDPDYPIQKISSKDHCQGDKSMFCRMEVLSRYCSIPGYNKLCCKSCNMYNNVTEEGNATD
SNANKNNVIEEELLTTPSPLTGVPTTQPATTSPPPVSKPPMPPSNATDEHPEINAVDVPY
KIDGLDNEVSQHNIITQRRIPYERTRNQRIQELIAEKRKKETLRRIN

>Xenopus tropicalis_ADAMTS2(ENSXETP_8331)
EYSLVTPVSTDSKGKYVSHSVTKRETHRYRRDASNLEKTSAERIYYNVTVFGREFHLKLR
VNSKLVAPGATIEWEEDANVTVIEPLNTNCLYVGDITDLPNASVAISNCDGLAGIIRTEE
EEFFIEPLEKDKEGEDEGRVHIVYRRNHTPPTLGPPKILAQIHRADTKTTQHSPNLLENI
IDNVQEQVNSTRKRTRRHASDDDFNIEILLGVDDSVVQFHGKEYVQKYLLTLLNIVNEIY
HDESLGAHINVVLVRIIMLSHSKSSSLIEVGNPSQSLENVCRWAYLQQKPETGHAEYHDH
AIFLTRQEFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG
NRCGDEVRMGSIMAPLVQAAFHRFHWSRCSQQELSRYLNSYDCLRDDPFEHNWPSLPQLP
GIHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHTDNPYFCKTKKGPPLDGTMCSYG
KHCFKGHCIWLTPDILRQDGNWGQWSKFGSCSRSCGTGVRYRTRSCDNPHPANGGRSCSG
PSYELQLCNTEDCKTDFDDFREEQCKQWDPYFEYQDSKHNWLPYDHPDEKERCHLYCQSK
ETGDVVYMKRLTHDGTRCSYKDSYNICVRGECLKVGCDKVIGSKKKEDKCGVCGGDNSHC
KVVKGTFTRTPRKQGNVRIFEIPVGARHLLIQETGASIHNLAIKNQASGKFILNDENVTL
PDSKIFVNMGIEWEYQNDDNRETVQTMGPLHNPITILVIPRGHSKISLSYKYMIHEDSFN
VDNNNVVEDVVVTYEWTLKKWSHCSKPCGGGHQFTKYGCRRKSDHKMVHKNFCDSIQKLK
PIRRVCNLQECSQPLWISGEWEPCTVTCGKSGYQFRTVKCIQPLNDNKNRSVHNKYCSDD
RPEAKRPCNRQPCPAQWRIGPWSQCSVTCGNGTEERQVHCGSDINKSANCSEEKPETIRI
CRLSPCSGNASDPYKKNYIVQWLSKLDPDYPLHKISSKESCLEDKSMVCRLGILQRYCSV
PGYSRMCCKACNASQLYNDSKMNSSSDPALPIPSPPTLYNTTVTFTPDYKQNVSNPNITD
QLNNRVDVPYKIQELQNEVPQLNAIPRRRSTFGRTKNQRIQQLIAEKVKQESKSKF

>Danio rerio_ADAMTS2(ENSDARP_121689)
MDVTPGCAFFIFFLHFQRADTLYIANSIDSLQHVLREYGLVRPVSVDADGHFLTHAVSAS
RLSGQGSHRRRRRQANQQGETDHLRETLFYNVTVYGQEFHLRLRLNSRLVAPGAKVEWLE
DDNQTHSEPLLPSDCLYVGYVTNVQDTSVAISNCDGLAGMIRAGQEEFFIEPLERGGDMT
GEEEGGPGRHHIVYRSSDIKKPAVNQPADFHPRGSPLGGLAALELLPQHVKKKINSRARR
ETYEDEIFNIEVLLGVDCSVVMFHGREHIQKYLLTLMNIVNEIYQDSTLGAHINVVLVRI
MMLCSSKSMGLIELGNASQSLENVCRWAFLQQKEDKNDAEYHDHAIFLTRQEFGPTGMQG
YAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQANECGDEVPMGSIMAPL
VQAAFHRFHWSRCSQQELRRYLNTYDCLRDDPFDHEWPTLPQLPGLQYSMDEQCRFDFGM
GYMMCTAYSTYDPCKQLWCSHPENPFFCKTKKGPPIDGTKCASGKNCFKGHCIKLTPDIL
RLDGHWGQWTKFGSCSRTCGGGVRFRTRECNNPVPANGGRTCYGNNYEFQLCNTEECAEA
LVDFREEQCKMWDPHFEHEGNKHHWLPYEHSEPDERCQLYCQSKETGDVVSMKRMVHDGT
RCSYKDPYSVCVRGECEKVGCDNVIASELEDDKCGVCGGDNSTCKIVKGNFTRSTRKPGF
LKILEIPRGARHIQIHEFKGTPHILAVKNQATDHLFLNDEGDFPESRTVIEKGVAWEYTN
NDDMETVQTTGPLRYGVLIMVQSHSISKVTISYKYILPEDPLSSMENTLPQDDTIYFEWA
LRKWSHCSKPCGGGKQYTRFGCRRKSDGKMVHRTLCANIPKPRAISRACNQKECSEPIWV
TGEWEECSKSCGKTGSQTRPVRCVRPELDGSYKAINAKYCNDDRPEGRRPCNRQLCPAHW
RTGPWSQCSVSCGNGTQERQVMCSTPDNAIGICMDTKPQSVRSCLPAPCPNDRGNFLIQW
LSRADPEFPAPKISSRSRCKGDKSVFCRMEVLSMYCSNPGYRQMCCKSCSETNYTSQFNL
TRPWTYTTATPPKTPIRTTLLFRTSQKPSTTTTPSISRWTDISPTSATTKTLKQTTTITF
TTGAFTKHPDSFDYEEESSGSFYEDETWSSVSESESSEFISSSSKPWSTTPQYTTTPENE
NIEMTLLTTPQPNVTATTSPPAIVSLHLSEDKKENNSIDVSYRIVSPNEVALNHFVPRKR
VSFREKTQNKRIQELLAEKRRQDFLLQRLKRKPGD

>Tetraodon nigroviridis_ADAMTS2(ENSTNIP_7400)
LVRPISVDAEGRFLSHAVSAGRVVGGQPRRRRRRDVGIGPDEWEEPKAEHVADREKLYYN
VTIFGREFHLRLRHNTRLVAPGAKMEWHDDSDSTRRTEPLHDACLYVGDITDTPGATVAI
SNCDGLAGMIRMEQEEFFIEPVERGAGVIEEKEQEGGGGRTHIVYRSSAVKKNSPVHSPH
ALCAGADLGAMMDLESLHRGVEQSINHTRAGRMRRQSLERSYNIEVLLGVDDSVVQFHGK
EHVQKYLLTLMNIVNEIYHDQSLGAKINVVLVRIIMLGYGKSMSLIELGNPSQSLENVCR
WAFLQQKQDTGDAEYHDHAIFLTRQEFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAF
VVAHETGHVLGMEHDGQGNRCGDEVHMGSIMAPLVQAAFHRFHWSRCSMQELGRYLHSYD
CLRDDPFDHNWPSLPQLPGLHYSMNEQCRFDFGVGYTMCTAYRTFDPCKQLWCSHPDNPF
FCKTKKGPPIDGTMCGNGKHCFKGHCIWLTPDIIKQDGNWGAWSEFGQCSRTCGGGVKFR
TRNCDNPRPANGGRTCVGATYQFQMCNTNECEDIYNDPREEQCRTWEPDFELHSNKHHWL
PYEHPDPNKRCNLHCQSKETRAVALTDRVVLDGTRCSYKDPHSVCVRGECEKVGCDGVFG
SSKQEDKCGVCGGDNSSCKTFKDTITRTSKKQGCLKVIEIPRGARHLLIQELKATSHTLA
VKNVASGLFFVNGENEYPESHSVIEKGVEWEYEYDNGKETLQTSGPLRHGILIMMKLHGD
EDVNLSYKYMMNMDSDTAIQNNMLVEDSSYEWAPKKWSYCSRPCSGGKQYLRYGCRRKVD
SKMVHKSFCNKSNMKPRGDVRDCNQKPCPPPVWVTGEWQNCSKTCGKTGTQIRTVSCMQP
SEDNTTRSIHNKHCNDHRPESRRACNRHPCPTQWRVGPWTQCSVTCGNGTQQRKALCHTR
DNTIGLCLDSKPDTIRVCRLDPCPKGSSDLNKNGNILIQWLSRPNPYPKISSRQRCTGDR
SSFCRIEALKRHCSLPDFRRMCCQSCGGVTNSSGGFVPIRPRVTSPPTSTSSINYFLPSS
FKPEVTTELFPSTIPSTGVPLTTVTTGSTKDPTTRARTPLWNTGVDGDVPQNNQIPKRRV
NFRERTKNKRIQELLEEKRNFLLRKKRGHA

>Homo sapiens_ADAMTS3(ENST_622135)
MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHT
LSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNI
TDPINNHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYF
IEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQ
LNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVH
INVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQD
FGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA
MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDE
QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC
MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLC
NTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYM
KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT
RTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDL
GVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVI
QEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCN
IQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP
CNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPC
LGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLP
RSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSK
TVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRS
STLER

>Mus musculus_ADAMTS3(ENSMUSP_58552)
MVFLSLWLIAASLVEVRTSADGQAGTDEMVQIDLPTKRYREYELVTPVSTNLKGHYLSHI
LSANHKKRSPRDVSSNSEHLFFNVTAFGRDFHLRLKPNTHFIAPGAVVEWHETAPRPGNT
TDPRNSHLHGSASEGSWRSEPLQTSCAYVGDIMDIPGTSVAISNCDGLAGMIKSDDEEYF
IEPLERGKQMDEENGRIHVVYKRSAVEQPPRDVSEDVYHRESDLEGLDDLGTVYSNIGQQ
LNKTMRRRRHTGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVH
INVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWACQQQKTDPNHAEHHDHAIFLTRQD
FGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA
MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFEHDWPKLPELPGINYSMDE
QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC
MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLC
NTEECQKHFEDFRAQQCQQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYM
KQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFT
RTPRKLGKTRGAFVLPKGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFID
LGVEWDYNIEDDIETLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNV
IQEELDTFEWALKSWSQCSEPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMC
NIQECTHPVWAADEWEHCSRSCGSSGNQLRTVRCLQPLQDGTNRSVHSKYCLGDRPESRR
PCNRVPCPAQWKTGSWNECSVTCGEGTEVRQVLCRTGDHCDGEKPESVRPCQLPPCNDEP
CLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSGTLPPPYLQEAAEIHSDAIFGPSDL
PRSLVMPTPFLPSSSGTRAEKKSLSSFSSMANPNADAAFRASSRASADFPRKRAHQAGRK
TLESVPSSSSIKTDHLRPASPVAAAPSPAISDSIGASPQTRTPKKDDAKSVSRRHPTRST
ASER

>Dasypus novemcinctus_ADAMTS3(ENSDNOP_2343)
MSKDVHYREPDLEGLDDLGTVYSNIEQQLNETTRRRRHAGENDYNIEVLLGVDDSVVRFH
GKEHVQNYLLTLMNIVNEIYHDVSLGVHINVVLVRMIMLGYTKSISLIERGDPSRSLENV
CRWACQQQKSDPNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSS
AFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHS
YDCLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDN
PYFCKTKKGPPVDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKYGACSRTCGTGVR
FRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECEKHFEDFRAQQCQQRNSHFEYQNTKHH
WLPYEHPDSKKRCHLYCQSKETGDVACMKQLVHDGTRCSYKDPYSICVRGECVKVGCDKE
IGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKGYLKMFDIPPGARHVLIQEDEASP
HILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDGIETLHTNGPLHDPVIVLII
PQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGRGFQYTKY
GCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRT
VRCFQPLHDGTKRSVHTVCVGDRPETPPCNRVPCPTCENGPCNECSVTCGEGMEVRQVIC
RAGDECDGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCASCSKR
SSTLSPPHPPEAAETQDDAMFNPSDLPQSLVMPTSLVPYHPETPAEKKSSLSRISSVEGP
NIYAAFRASNKPDGANLPLRRAQQAESETLRLVSVPSSPPTKSHHLSSSLQMAASPFLAV
SDSIGASSHARTSKKNEKRRPIRSSTLER

>Danio rerio_ADAMTS3(ENSDARP_78846)
MVVLSLRLLIVGVVSVQKKAQGNTECLSCVILDLLKNRLKEYGLITPISTDAEGHFLSHF
LSANHKQRVKRDVLEGSAPAPDRLFFNITVFGKEFHLRLHPNQRLVAPGAMVEWHDDIEI
AGNATDNRTHFERILKRELLKTDCTFIGDITDVPGASVAINNCDGLAGMIRTDSDEYFIE
PLEQGTQEHEERGRVHVVYRRSAVLQTPSDISLDYQPIAGDLECQPELDTPRMLDNIAKQ
VNKTVRRRRHAGDEDYNIEILLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLEVH
INVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWAFVQQKEDPEHSEHHDHAIFLTRQG
FGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA
MGSVMAPLVQAAFHRYHWSMCSGQELKRYIHSYDCLLDDPFKHDWPQLPELPGINYSMDE
QCRFDFGVGYKICTSFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCYKGHC
MWKNANQVKQDGAWGAWSKYGSCSRSCGMGVRFRTRQCNNPVPSNGGQDCPGVNYEYQLC
NTDDCPKHFEDFRAQQCQLRNSHFEYQNAKHHWLPYEHPDANKRCHLYCQSKETGDVAYM
KQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFT
RVPKKAGYLKMFLIPPGARHVIIQEHEASPQILAIKNQATGHYVLNGKGEDARSRRFIEM
GVEWDYLVEEDVETLHTDGPLNDAIVVLIIPKDNETRSTLMYKYIIHEDSVPLNNNNVIQ
EDTYEWALKSWSQCSRPCAGGFQYTKYGCRKKGDNKMVHRGYCDVNKKPKPIRRMCNLQD
CTQPQWITEEWEHCTKTCGSLGYQIRTVRCVQFLHEGTNRSIHSKYCNGEKPEMRRACNR
VACPAQWRTGAWSECSVSCGEGVSRRLVTCRIGDQCTGEKPESQKPCRPRPCHDEPCGGD
KSIFCQMEVLARYCSIPGYNKLCCESCSRRSGTFAPLLHEAAETEEELRFG

>Takifugu rubripes_ADAMTS3(ENSTRUP_39914)
LTQQVNDTVKRRRRRRDAGEDDYNIEILLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYH
EESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWAFVQQKSDPDHAEHHDHA
IFLTRQGFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGN
RCGDETAMGSVMAPLVQAAFHRYHWSMCSGQELKRYIHTYDCLLDDPFKHDWPQLPELPG
INYSMDEQCRFDFGVGYKICTSFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGK
WCYKGHCMWKNPNQVKQDGAWGSWSKYGSCSRSCGTGIRFRTRQCNNPAPSNGGQDCPGV
NFEYQLCNTDDCPKHFEDFRAQQCQLRNSHFEFQNTKHHWLPHEHPDANKRCHLYCQSKE
TGDVTYMKQLVHDGTRCSYKDAYSICVRGECVKVGCDREIGSTKVEDKCGVCGGDNSHCR
TVKGSFTRTPKKPGYLKMFYIPPGARHVVIQEHEASPQILAIKNQATGHYILNGKGEELK
SRSFIDLGVEWHYIMDRDVETLHTDGPLHDPVVVLIIPKDNETRTTLMYKYIIHEDSVPV
NNNNVIQEDTYEWALKSWSPCSKPCAGGFQYTKYGCRKKGDTKMLHKGYCDASKKPKPIR
RMCNLQDCTQPQWITDEWENCPRSCGSLGFQIRIVRCVQFLHDGTNRSVHSKYCSGEKPE
SRRPCNRVPCPAQWRTGAWSECSVTCGEGVERRLVTCRIGDQCSREKPEAVRPCRLGPCH
DEPCYGDKSIFCQMEVLARYCSIPGYNKLCCDSCSRRSGTLSMFAEAAET

>Gasterosteus aculeatus_ADAMTS3(ENSGACP_19109)
LITPFSTDSHGRYLSHLLSAAHKQRTKREAPPPGGAEQELFFNISAFGEEFHLRLRPNNR
LVAPGAVVEWHDADDGGEQGGNQTERNPHRELLKTDCTFIGDITDVPGASVAINNCDGLA
GMIRTDADEYFIEPLERGTQELEHQGRVHVVYRRSALLQPPADPPGDDDDLPPGYPMASE
DLRSVAFAAGAITERFNMQQDNRDKHAGEDDYNIEILLGVDDSVVRFHGKEHVQNYLLTL
MNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWAFVQQKSDS
EHAEHHDHAIFLTRQGFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVL
GMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSMCSGRELKRYISTYDCLLDDPFKHD
WPQLPELPGINYSMDEQCRFDFGVGYKICTSFRTFDPCKQLWCSHPDNPYFCKTKKGPPL
DGTECNPGKWCYKGHCMWKNPNQVKQDGAWGSWSKYGSCSRSCGTGVRFRTRQCSSPPPS
NGGQDCPGLNYEAALCNADDCPKHYEDFRAQQCQLRNSHFEFQNAKHHWLPYEHPDASKR
CHLYCQSKESGDVAYMKQLVHDGTRCSYKDAYSICARGECLKVGCDREIGSSKAEDRCGV
CGGDNSHCRTVKGSFTRAPKKPVGEGSLKMFLIPPGARRVIVQEHEASPHILAIKNQATG
HYILNGRGEEAASRSFIDLGVEWNYILEDQVEMLHTDGPLHDPVLVLVIIPKDNETRSTL
MYKYIIHEDSVPVNNNNVIQEDTYEWALKSWSPCSKPCAGGFQYTKYGCRKKGDTKMVHR
GYCDAGKKPKPIRRMCNLQDCTQPQWSSDDWEHCTKTCGSLGFQIRTVRCVQCLSDGTNR
SVHSKYCSGEKPESRRPCGRVSCPAQWRTGAWSECSVTCGEGMERRLVTCRIGDQCNGDK
PETVRFCRPAACHDILPFSSQQQYNVAVIRFQPAPSSPRSDEPCSGDKSIFCQMEVLARY
CSIPGYSKLCCDSCS

>Homo sapiens_ADAMTS4(ENST_367996)
MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEE
IVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLG
GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHI
LRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR
YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLN
TPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA
HELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGY
GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA
MCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGV
QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSF
PGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHA
GCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNP
GHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQP
LTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK

>Mus musculus_ADAMTS4(ENSMUSP_106947)
MASIHPSCSPGTMSQMGLHPRRGLTGHWLQRFQPCLPLHTVQWRRLLLLAFLLSLAWPAS
PLPREEEIVFPEKLNGSSILPGSGVPARLLYRLPAFGEMLLLELEQDPGVQVEGLTVQYL
GQAPEMLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGALNS
AGGPGAHILRRKSPASSQGPMCTVKAPSGSPSPISRRTKRFASLSRFVETLVVADDKMAA
FHGTGLKRYLLTVMAAAAKAFKHPSIRNPVNLVVTRLVILGSGQEGPQVGPSAAQTLRSF
CTWQRGLNTPNDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDG
LQSAFTAAHELGHVFNMLHDNSKPCTNLNGQGGSSRHVMAPVMAHVDPEEPWSPCSARFI
TDFLDNGYGHCLLDKPEAPLHLPATFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWC
SGHLNGHAMCQTKHSPWADGTPCGSSQACMGGRCLHVDQLKDFNVPQAGGWGPWGPWGDC
SRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTENCPHGSALTFREEQCAAYNH
RTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQARALGYYYVLEPRVADGTPCSPDTSSVC
VQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSRCSKQSGSFKKFRYGYSDVVTIPAGATHI
LVRQQGGSGLKSIYLALKLSDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLS
GHGPLAQPLTLQVLVAGNPQNARLRYSFFVPRPVPSTPRPPPQDWLQRRAEILKILRKRP
WAGRK

>Dasypus novemcinctus_ADAMTS4(ENSDNOP_31171)
MSQTESLPPSCSTSAMSQTGLHPRKGLAGRWLWGVQLRLLLPTVLLSGLVRPLLLLLLLL
ASLLPSARPASPLPREEEIVFPEKLNGSVLPGLGIPARLLYRLPAFGETLLLELEQDPGV
RVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYQGAELHL
QPLEGGSPNSAGGPGAHILRRKSPASGQGPMCNVKAPPGRPSPSPRRAKRFASLSRFVET
LVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGPGEEGPQVG
PSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPA
RSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCVGLNGPGSTSRHVMAPVMAHVDPEE
PWSPCSAHFITEFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQ
LPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHIDQLRDFNIPQAGG
WGPWGPWGDCSRSCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTQDCPAGSALTF
REEQCAAYNHHTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQARALGYYYVLKPRVVDGT
PCSPDSSSVCVQGRCIHAGCDHIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNDV
VTIPVGATHILVRHQGTSGPRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYS
GATAASETLSGHGPLTQPLTLQALVAGDPQNTRLRYSFFVPRPAPAAAAPRPPPQDWQHR
RAQILEILRRRPWAGRK

>Homo sapiens_ADAMTS5(ENST_284987)
MLLGWASLLLCAFRLPLAAVGPAATPAQDKAGQPPTAAAAAQPRRRQGEEVQERAEPPGH
PHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSVGIAGFVPAGGGT
SAPWRHRSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGR
VYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLD
QSALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPR
NNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCPLSQRPSAFKQCLLKKC

>Mus musculus_ADAMTS5(ENSMUSP_23611)
MRLEWAPLLLLLLLLSASCLSLAADSPAAAPAQDKTRQPQAAAAAAEPDQPQGEETRERG
HLQPLAGQRRSGGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDTVGAAGSIVTAGG
GLSASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGSWAEYER
IYGDGSSRILHVYNREGFSFEALPPRASCETPASPSGPQESPSVHSRSRRRSALAPQLLD
HSAFSPSGNAGPQTWWRRRRRSISRARQVELLLVADSSMARMYGRGLQHYLLTLASIANR
LYSHASIENHIRLAVVKVVVLTDKDTSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD
AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH
DDSKFCEENFGTTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI
LGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGT
PCGKGRVCLQGKCVDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPR
NSGRYCTGKRAIYRSCSVTPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVL
PADVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDK
CGVCGGDNSSCTKIIGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKK
TGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPT
KALDVRYSFFVPKKTTQKVNSVISHGSNKVGPHSTQLQWVTGPWLACSRTCDTGWHTRTV
QCQDGNRKLAKGCLLSQRPSAFKQCLLKKC

>Gallus gallus_ADAMTS5(ENSGALP_25424)
ARYTVRPARRGGEEEDEGGPRIYGEGPARAPHFFRRERFSFETLPARPSCETRGPAGAAT
APESGRRRRRRRRSVSRARQVELLLVADASMARKYGKGLQHYLLTLASIASRLYAHASLE
NHVRLAVVKVVVLGEKEKGLEVNRNAATTLKNFCKWQHQHNRLDDDHDEHYDAAILFTRE
DLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEE
NFGSMEDKRLMSSILTSIDASKPWSKCTSATITEFFDDGHGNCLLDQPRKQILGPEELPG
QTYDAIRQCKLAFGPEYTVCPGMDVCSRLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRIC
LQGKCVDKTKKKYYSASSHGNWGSWGPWGQCSRTCGGGVQFAYRHCNNPAPRNNGRYCTG
KRAIYRSCNVTPCPANAKSFRQEQCEARNGYQSDAKGVKTFVEWVPKYAGVLPGDVCKLT
CRAKGTGYYVVFSQKVTDGTECRPYSNSVCVRGKCIRTGCDGIIGSKLQYDKCGVCGGDN
SSCTKVMGTFTKKSKGYTDIVKIPEGATHIKVRQFKTKDQSRFTAYLALKKKNGEYLVNG
KYMISTSETIIDINGTVMNYSGWSHKDDFLHAMGHSATKEVLIVQILATDPTQPVDVRYS
FFVPKKQGQMTNSVTGSGSSSKVTPQLTQPRWVTGPWLSCSRTCDTGWHTRTVQCKDGHG
KLAKGCLLSQRPSAFKQCLLKKC

>Xenopus tropicalis_ADAMTS5(ENSXETP_29878)
QIYAGGGKVGYILYADGKKFLLDLERDELLLSPHFSTKYLGRLHPQHRFQRHCFYRGTVD
SSPQSLAVFNLCGGLDGYFAVKHAHYTIKPLIKGTAETVPTRASCETHGLRKRLHKHGKG
ATRHPHQHQQTQENPQKANQTSAPSDPNLKETLFQSTALKKRQRRSVSKSRQVELLLVAD
ESMAKKYGKDLHHYLLTLASIASRLYSHPSIENHIRLAVVKVVMLTDKDKGPEVSKNAAT
TLKNFCKWQHQHNQLDDEHDQHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAV
IEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSLEDKRLMSSVLTSIDASKPWSKCT
SATITDFLDDGHGNCLLDQPRNQILGPEELPGQSYDAIRQCKLAFGPTYTVCPGMDVCSR
LWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLHGKCVDKNKKKYYSVSSHGNWGSWGPW
GQCSRTCGGGVQFAYRHCNNPAPKNSGKYCIGKRAIYRSCNVTPCPSNVSKSFRQQQCEA
RNGYQTDAKGVKTFVEWVPKYAGVQPGDVCKLICQAKGTGYYVVFSQKVTDGTECRPYSN
SVCVRGKCVRTGCDGIIGSKLQFDKCGICGGDNSSCTKVMGTFTTKSKGYTDIVKIPEGA
THIKVRQYKAKDQTRFTAYLALKKKSGEYITNGKYMISTSETIIEMNGFVMNYSGWSHAE
DMLHSMGHSSTQEVLIVQILATDQSKPLDVRYSFYVPSKQVPNTNSINNINNVVPKISQP
QWVTGPWLSCSRTCDTGWHTRTVQCQDGHGKLAKGCLLSQRPSAFKQC

>Takifugu rubripes_ADAMTS5(ENSTRUP_27713)
PPANGSLLAPARRTDGVVRTIDRIYHGGGKVGYLLYLDGSRFLLDMERDESALSHPFSPQ
MGESPAPLQRECVYRGTVDSNPESLAVFNLCGGGLQGFFALNHSRYSITPIVRAKGHEHD
VRTLQDKDAESALHAFTRESFSFEATREGRESCGTRDGRRGRRLRRHRKGARDGEGLAGE
SGRHGSRGRRWRSRPAAAPVRRRERSVSRARYVELLLVADDTMTKKYGKDLNHYLLTLAS
IASKLYGHASIENPIRLSVVKVTTVGEKEKGLEVSKNAAATLKSFCKWQNQQNSLDDDHQ
HHHDAAILFTRQDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLL
GLSHDDSKFCEERFGVNSDKRLMSSILTSIDASKPWSRCTSATITDFFDDGNAECLLDSP
RQPLLGSEELPGQSYDAVRQCRLAFGPEYTVCPGMDVCSRLWCAVIRQGQMVCLTKKLPA
VEGTPCGKGRICLQGKCVDKTRKRHYSASNHGSWSSWGPWGSCSRSCGGGVQFAQRLCNN
PPPRNNGRYCTGKRAIYRSCNVSPCPPSTKSFRAEQCEVRNGPQTDPKGVKTFVEWVPKY
AGVLPKDVCKLTCRAKGTGYYVVFSQRVTDGTECRPYSSSVCVKGKCVRTGCDGIIGSKL
QYDKCGVCGGDSTGCIRVVGNFTKKSKGYTDVVKIPAGSTHLKVRQHKAKDQTRYSAYLA
LRRPNGDYLLNGKFMISTSETIIPLNGSVLNYSGWSQRDEWLHSMGPGALQEALVVQILA
TDAKKPLDIRYSFFMPRRTTPQQPSVPLLPYPKPTTAHSTTTLSTMSPGPQWVTGSWMTC
SRTCDTGWQSRTVQCKNLDGKLSKGCILSFRPSAFRPCVVKKC

>Gasterosteus aculeatus_ADAMTS5(ENSGACP_19882)
PPANGSLLTPARRTDGVVRTIDRIYHGGGKVGYLVYLDGSRFQLDLERDELVLSHHFSPQ
YVLAMMGGSHAALQRECVYRGTVDSKPESLAVFNLCRGGLEGFFAVDHARYTIAPIIRAK
GQEHDMRALQDKDAESALHVFTRESFSFEAMREGRESCGTRDGRRGRGDAAGRRRAAEHG
ALERTRWSRLARAAAAEHGARSKRSVSRARHVELLLVADETMVQKYGKDLNHYLLTLASI
ASKLYGHASIENPIRLSVVRVAVVTEKEKGLDLACEHVTSLDSALSWAFVLHPPLSSDHR
AYFSLPPSFQESAPFVQDLCGHHSCDTLGMADVGTVCSPERSCAVIEDDGLHAAFTVAHE
IGHLLGLSHDDSKFCEERFGVNSDKRLMSSILTSIDASKPWSRCTSATITDFFDDGNAEC
LLDSPRQPLLGPEELPGQSYDAVRQCRLAFGPEYTVCPGMDVCARLWCAVIRQGQMVCLT
KKLPAVEGTPCGKGRICLQGKCVDKTRKKHYSASNHGSWSSWGPWGGCSRTCGGGLQFAQ
RPCNNPPPRNNGRYCVGKRAIHRSCNVTPCPTSNKSFRLEQCEVRNGPQTDPKGMKTFVE
WVPKYAGVLPKDMCKLTCRAKGTGYYVVFSQRVVDGTECRPYSSSVCVKGKCVRTGCDGI
IGSKLQFDKCGICGGDSTGCIRIVGNFTKKSKGYTDVVKIPAGSTHVKVRQHKAKDQTRY
TAYLALRRPNNEYLLNGKFMISTSETIIPLNGSVLNYSGWSQRDEWLHSMGPGALREALV
VQILATDSKRPLDVRYSFFMPRRTAPQQPSPLLYHHYNFLCSLPPGPRWVTGSWMTCSRT
CDTGWQSRTVQCKDQDGKLSKGCTLGARPSAFKHCLVKKC

>Oryzias latipes_ADAMTS5(ENSORLP_6260)
RRTDGVVRTIDRIYHGGGKVGYLVYLDGRRFQLDMERDESVLSDHFSPQYVMALMGQSSA
PSQRECAYRGTVNSEPESLAVLNLCGGGLEGFFAVNQSRYTITPIIRARGHEHDVRALQD
KDAESALHVFTRESFRFEAANDGRESCGTRDRARRGRKRKPHNREDEGGARRRRSVSRAR
HVELLLVADDSMAKKYGKDLNHYLLTLASIASKLYGHASIENPIRLSVVKLVVLSEREKG
LEVSKNAAATLKSFCKWQNQQNPLDDDHPHHHDAAILFTRQDLCGHHSCDTLGMADVGTI
CSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEERFGVNSDKRLMSSILTSID
ASKPWSRCTSSTITDFFDDGNAECLLDSPRQSLLGPEELPGQSYDAVRQCRLAFGPEYTV
CHGMDVCSRLWCSVIRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTRKKHYSTSNH
GSWSSWGSWGSCTRTCGGGVQFAQRLCNNPPPRNNGRYCTGKRAIYRSCNVTPCPPSNKT
FRQEQCEARNGPQTDPKGVKTFVEWVPKYAGVLPKDVCKLTCRAKGTGYYVVFSHRVVDG
TECRPYSSSVCVKGKCVRTGCDGIIGSKLQYDKCGVCGGDSTGCIRVVGNFTKKSKGYTD
IVKIPAGSTHIKVRQHKAKDQTRFTAYLAFRRPNGEYLLNGKFMISTSETIVPLNGSLLN
YSGWSQRDEWLHSMGPGALQEPLVVQILATDAKKPLDVRYSFLMPRVTSPQQLLAPKLTQ
SQSTTTTSSTTGPQWVTGSWMACSRTCDTGWQSRTVQCKDQHGKLSKNCLIGVRPSAFRH
CLVKKC

>Homo sapiens_ADAMTS6(ENST_381055)
MEILWKTLTWILSLIMASSEFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT
VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDG
PQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHF
SYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWWLNDTSTVSYSLPINNTHIHH
RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA
RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD
ICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC
GTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAP
GQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG
WCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE
RKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEGYN
FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE
GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF
DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEV
GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP
PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP
PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPP
RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNT
EECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH

>Mus musculus_ADAMTS6(ENSMUSP_64570)
MEISWKTLTWILSLIMASSEFYSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT
VKNDKHSRRRRSMDLLDPQQAVSKLFFKLSAYGKHFHLNLTLNTNFVSKHFTVEYWGKDG
PQWKHDFLDNCHYTGYLQDQHSTTKVALSNCVGLHGIIATEDEEYFIEPLKNTTEDSKHF
SYENGHPHVIYKKSTLQQQHIYDHSHCGVSDLTGSGKPWWLNKTSSFPSLPPINDTHIHH
RKRRSVSTERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA
RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD
ICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC
GTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAP
GQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKG
WCYQGDCVPFGTWPQSIDGGWGSWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGE
RKRYRSCNTDPCPLGSRDFREKQCADFDSMPFRGKHYNWKPYTGGGVKPCALNCLAEGYN
FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE
GFFNDSLPRGGYMEVVQIPRGSVHIEVREVSMSKNYIALKSEGDDYYINGAWTIDWPRKF
DVSGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPIVRTGSGDNEV
GFMWTYQPWAECSATCAGGVQRQEVVCKRLDDNSIVQNNFCDPDSKPPENQRACNTEPCP
PEWFIGDWLECSKTCDGGMRTRAVLCIRKVGPSEEETLDYGDCLTHRPVEKESCNNQSCP
PQWVALDWSECTPKCGSGFKHRIVLCKSSDLSKTFPAAQCPEESKPPARIRCSLGRCPPP
RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASVDCPETVRPPSMQQCDSKCDSTPLSST
EECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH

>Gallus gallus_ADAMTS6(ENSGALP_23740)
MEIFWKTWTWILSLVMVSSEFHSDSRLSYSSQEEFLSYLEHYQLTIPIRVDQNGAFLSFT
VKNAKPSRRRRSTDPYDQELSASKLFFKLSAYGKHFHLNLTLNTDLVSRHFTVEYWGKDG
PQWKHDFLDHCHYTGYLQDQHTTTKVAVSNCNGLHGVIATEDEEYFIEPLKNVTANSSNF
TYENGHPHVIYKKSTMRQHLLYDHSRCGVSEDLTRSSKPWWMSDGSAFPTSLPVNDTLSS
HSRQKRSVSLERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNII
VTRLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITR
YDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGN
SCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAV
APGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGSIE
KGWCYQGECVPFGTWPQSIDGDWGPWSIWGECSRTCGGGVSSSIRHCDSPAPSGGGKYCL
GERKRYRSCNTDPCPAGARDFREKQCADFDNMPFRGKYYNWKPYTGGGVKPCALNCLAEG
YNFYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAKEDRCRVCGGDGSTCEA
IEGFFNDSLPRGGYMEVIQIPRGSVHIEIREVAVSKNYIALKSEEDDYYINGAWTIDWPR
KFDVAGTAFHYKRPTDEPESLEALGPTSENLIVMILLQEQNLGIRYKFNVPISRTGSGDN
EVGFAWNHLPWSECSATCAGGVQKQEVVCKRLDDNSVVQNNYCDPDSKPPENQRACNTEP
CPPEWFIGDWSECSKTCDGGVRSRTVLCIRKIGPSEEETLDSTNCLTHRPIEKEPCNNQS
CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLLKTFPAAQCQEESKPPVRIRCSLGRCP
PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSECSETHRPPSMQQCESKCDSTPIS
NTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH

>Danio rerio_ADAMTS6(ENSDARP_117393)
MEIFWKTLTWIFSLVLAAAEAQILSYNSQAEFLSTLEHYQLTVPVRVNEKGQFMSYTVKH
YRPGRRRRGLDQTELDHTETRLFYKLSAYGKHFHLNLTLNPNLVSKHFTVEYWGKDGLDW
QHSVVDNCHYVGYLLDQYSTTKVALSNCKGLHGVITTEDEQYLIEPLKNISRNFSDVNHE
GQPHVIYKKTSIPSPQEPSKEFSCGVSDLTVNRTQFYNTNPKLNPDFPVLGVDSLMGAHR
QRRSVSSERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDASLGNVVNIIVTR
LIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQGDGNSIPENGIAHHDNAVLITRYDI
CTYKNKPCGTLAGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC
GTKGHETAKLMAAHITANTNPFSWSACSKDYITSFLDSGRGTCLDNEPLKRDFLYPTVAP
GQVYDADEQCRFQYGASSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTNTIEKG
WCYQGECVAFGTWPQSVDGSWGPWTVWGECSRTCGGGVSSSMRHCDSPAPSGGGKYCLGE
RKRYRSCNTDACPEGSRDFREKQCADFDSLPFRGKYYNWKPYTGGGVKPCALNCLAEGYN
FYTERSPAVIDGTRCQGDSLDICINGECKHVGCDNILGSDAKEDRCRVCGGDGSTCELTE
GLFNDSLPRGGYMEVVQIPKGSVHIEIREVAVSKNYIALKSEGDDYYINGAWTIDWPRKF
DIAGTAFHYKRPTDEPESLEALGATMENLVVMVLLQEQNLGIQYKFNVPIQRTGSGDNEV
GFSWHHLPWSECSATCAGGSQKQEVVCKRLDDNSVVQNSYCDQDSKPPGNQRRCNTEPCP
PEWFIGDWSECGKTCDGGIRTRTVLCIRKINPAEEETLEDSHCLTHRPIEQESCNNQSCP
PQWVTLDWSECTPKCGPGFKHRIVLCKSSDLTKTFPAALCSDHSKPPVRIRCSLGRCPPP
RWIPGEWGQCSAQCGLGQQMRTVQCLSYTGQPSSECLDSLRPNTMQQCESKCDSTPISGG
DECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH

>Takifugu rubripes_ADAMTS6(ENSTRUP_47110)
YQLTVPVRVDENGEFLSYTVKHHRPGRRRRGAGDPVVGPSPSLDPLESRLFYSLSAYGKH
FHLNLTLNPHLVSRHFAVEYWGKDGLQWRHNTADNCHYVGVLQNQHGTTRVALSNCKGLH
GVITTEEEQYLIEPLKNTSSTTSSEWNLEEAQQHVIYKMSAIPSPQEPSQEETAKAVIGR
KLACLNLHHLIAFSQSDWVIKQRPWLLSTPSPLHPSAEPKNGSEQSGDGHRRRRSVSSER
FVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDASLGNVVNIIVTRLIVLTEDQP
NLEINHHADKSLDSFCKWQRTVLSHHSGGNSIPENGMAHHDNAVLITRYDICTYKNKPCG
TLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHETAKL
MAAHITANTNPFSWSACSKDYITSFLDSGRGTCLDNEPLKRDFLYPTVAPGQVYEADEQC
RFQYGASSRQCKYGLKQEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGSIDKGGECVAFG
TFPQSLNGNWGPWSMWGECSRTCGGGVSSSMRHCDSPAPSGGGKYCLGERKRYRSCNIDA
CPAGSRNFREKQCADFDNMPFRGKYYNWKPYAGGGVKPCALNCLAEGYNFYTERSPAVVD
GTRCQADSLDICINGECKHVGCDNILGSDAKEDRCRVCGGDGSTCETTEGLFNQSLPRGG
YMEVVQIPKGSVHIEIKELAMSKNYIALKSEGEEYYINGAWTIDWPRKFDIGGTTFHYKR
PSDEPESLEAMGPTTENLFVMVLLQEQNQGIRYKFNVPIQRTGSGDNEVGFSWNHLPWSE
CSTTCSGGSQKQEVVCKRLDDNSVVQNNYCDPDGKPPENHRDCNTEPCPPEWFIGDWSEC
GKTCDGGIRTRSVLCIRKISAAVEETLEDVHCLTHRPIEQESCNNQSCPPKWVTLDWSEC
TPKCGPGFKHRIALCKSSDLAKTFPPAQCSSHSKPPVRVRCSLGRCPPPRWTPGEWGQTA
LNASSSTQNRALRCLEDGSLSRMIIFWLWPCWLRPKSDADAQSSSNRKPRPRCSPPKASA
RPKGHWFKSHCSAQCGLGQQMRTVQCLSYTGQPSNECSDTLRPAMMQQCESKCDATPISN
GDECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC

>Tetraodon nigroviridis_ADAMTS6(ENSTNIP_16488)
MEILWKTLTWTLSLVVMAASDLQNLNRLSHNSQDKEELLSYLQHYQLTVPVRVDENGEFL
SYTVKHHRPGRRMHPPEPRLFYRLSAYGKHFHLNLTLNPQLVSRHFTVEYWGKDGLEWRH
NTVDNCHYVGFLQNQHGTTRVALSNCKGLHGVITTEEEQYLIEPLKNTSSTTSGEWSLEE
AQQHVIYKMSAIPSPQEPSQEFSCGLSDLIKSSPPCQLSSPSPPHPSAEPKNGSEPSGGG
RRRRRSVSSERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDASLGNVVNIIV
TRLIVLTEDQQPNLEINHHADKSLDSFCKWQKTISTHHSGGNSIPDNGVAHHDNAVLITS
RYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIG
NSCGTKGHETAKLMAAHITANTNPFSWSACSKDYITSFLDSGRGTCLDNEPLKRDFLYPT
VAPGQVYGADEQCRFQYGASSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQSGSI
EKGWCYQGECVAFGTFPQSLDGDWGPWSTWGECSRTCGGGVSSSMRHCDSPAPSGGGKYC
LGERKRYRSCNIDVQCFFQSRDFREKQWADFDSMPFRGKYYNWKPYAGAGGVKPCALNCL
AEGYNFYTERSPAVIDGTRCQADSLDICINGECKHVGCDNILGSDAKEDRCRVCGGDGST
CETTEGLFNDSLPRGGYMEVVQIPKGSVHLEIKELAMSKNYIALKSKEEDYYINGAWTID
WPRKFDIGGTTFHYKRPADEPESLEALGPTTKNLVVMVLLQEQNQGIRYKFNVPIQRTGS
GDNEVGFSWNHLPWSECSTTCSGGSQKQEVVCKRLDDNSVVQNNYCDPDGKPPENQRDCN
TEPCPAEWLIGDWSECGKTCDGGIRTRTVVCIRKISPTVEETLEDVHCLTRRPIEQESCN
NQSCPPKWVTLDWSECTPRCGPGFKHRIALCKSSDLTKTFPPAQCPSQSKPPVRVRCSLG
RCPPPRWTPGEWGQCSAQCGLGQQMRTVQCLSYTGQPSNECLETLRPAMMQQCESKCDAA
PVSNSDECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH

>Gasterosteus aculeatus_ADAMTS6(ENSGACP_20731)
MEILWKTLTWTLSLVVMAASEFQRLSHNSQASLEEFLSYLQHYQVTVPVRVDESGEFLSY
TVKHHRPGRRRRGVPDPLDPDPPHHNPRLFYRLSAYGMHFHLNLTLNPHLVSKHFAVEFW
GRDGLEWRHDAVDNCHYVGSLQNQRGATRVALSNCKGLHGVITTEEEQYLIEPLRNISSS
EWNLEEAQQHVIYKMSAIPSPQERSQELSCGISDLIKSSSPCQFSSPPPPAPQSDGERAN
GTHRPRRSVSSERFVETLVVADKMMVGYHGRKDIEGYILSVMNIVAKLYRDASLGNVVNI
IVTRLIVLTEDQPNLEINHHADKSLDSFCKWQKSIRSHHGDGNSIPENGMAHHDNAVLIT
RYDICTYKNKPCGTLVGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGI
GNSCGTKGHETAKLMAAHITANTNPFSWSACSKDYITSFLDSGRGTCLDNEPMKRDFLYP
TVAPGQVYDADEQCRFQYGTSSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGS
IEKGWCYQGECVAFGTWPQSEDGGWGPWSTWGECSRTCGGGVSSSMRHCDSPAPSGGGKY
CLGERKRYRSCNTDACAAGSRDFREKQCADFDLMPFRGKYYNWKPYTGGGVKPCALNCLA
EATTFYTEGSPAVVEGTGCQVDSLDICINGECKHVGCDNVLSSDAKEDRCRVCGGDGSTC
EATEGLFNDSLPRGGYMEVVQIPKGSVHIEIKEVAMSKNYIGRGGGGGDYYINGAWTIDW
PRKFDIAGTAFHYKRPSDEPESLEALGATTEVLVVMVLLQEQNLGIRYKFNVPIQRTGSG
DNEVGFSWHYLPWSECSATCAGGSQKQEVVCKRLDDNSVVQNNYCDPDSKPPENQRDCNT
EPCPPEWFIGDWSECGKTCDGGMRTRTVLCIRKMGPAEEETLEDTHCLTHRPMEREACNN
QSCPPKWVTLDWSECTPKCGPGFKHRIALCKSSDLATFPPAHCPSHNKPPVRIRCSLGRC
PPPRWIPGEWGQCSAQCGLGQQMRTVTCLSYTGQPSGDCAESLRPATMQQCESKCDATPV
SNGDECKDVNKVAYCPLVLKFKFCSRAYFRQMCCRTCQGH

>Oryzias latipes_ADAMTS6(ENSORLP_2455)
MEILWKTLTWTLSLVLMAASEFQSRLSYNSQEEFLSYLQHYQLTVPVRVDQKGDFLSYTV
KHQRPGRRRRGLADSTMGSDPPETQMFYRLSAYGKHFHLNLTLNPHLVSKHFTVEYWGRD
GPEWRHGVVDNCHYVGFLQDQDSTTRVALSNCKGLHGVITTEEEQYLIEPLKNASAAPFS
ERSQNEEAHQHVIYKMSAISSPQEQSQEFSCGISDLIKSDAPCQLSKSSALHLSPHNHEL
SNNTRRQRRSVSSERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVV
NIIVTRLIVLTEDQPNLEINHHADKSLDSFCKWQKSIRSHHSGGNSIPENGMAHHDNAVL
ITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDG
IGNSCGTKGHETAKLMAAHITANTNPFSWSACSKDYITSFLDSGRGTCLDNEPLKRDFLY
PTMAPGQVYEADEQCRFQYGASSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTG
SIEKGWCYQGECVAFGTWPQSQDGGWGPWSMWGECSRTCGGGVSSSTRHCDSPAPSGGGK
YCLGERKRYRSCNIDACSAGSRDFREKQCADFDSMPFRGKYYNWKPYTGGGVKPCALNCL
AEGYNFYTERSPAVIDGTRCQADSLDICINGECKHVGCDNILASDAREDRCRVCGGDGST
CEATEGLFNDSLPRGGYMEVVQIPKGSVHIEIREVIVSKNYIALKSEGEDYYINGAWTID
WPRKFDIAGTTFHYKRPTDDPESLEALGPTTENLVVMVLLQEQNLGIRYRFIVPIQRTGS
GDNEVGFAWHYLPWSECSATCAGGTQKQEVLCKRFDDNSVVQNSYCDSDSKPPENQRDCN
TEPCPPEWFIGDWSECGKTCDGGIRTRTVLCTRKIGPAEEETMKDSHCLTHRPIERETCN
NQSCPPKWVTLEWSECTPKCGPGFKHRIALCKSSDMTKTFPPSHCPSHNKPPVRIRCSLG
RCPPPRWIPGDWGQCSAHCGLGQQMRTVTCLSYTGQLSNECPESLRPATMQQCESKCNST
PISNGDECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH

>Homo sapiens_ADAMTS8(ENST_257359)
MLPAPAAPRWPPLLLLLLLLLPLARGAPARPAAGGQASELVVPTRLPGSAGELALHLSAF
GKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPESLAAVSLCR
GLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERG
DHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADASMAAFYGADLQ
NHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRF
NQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHT
LAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGG
HGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTD
GAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSR
TCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNY
TDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQ
CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQ
RSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFR
PLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGD
WSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCPL

>Mus musculus_ADAMTS8(ENSMUSP_69644)
MLRDPTTTGWPPLLLLLLQLPPPPLVCGAPAGPGTGAQASELVVPTRLPGSASELAFHLS
AFGQGFVLRLAPDASFLAPEFKIERLGGSSAAAGGEPGLRGCFFSGTVNGERESLAAMSL
CRGLSGSFLLAGEEFTIQPQGAGDSLDQPHRLQRWGPGQRREDPGLAAAEVFPLPQGLEW
EVEMGNGQGQERSDNEEDRKQDKEGLLKETEDSRKVPPPFGSKTRSKRFVSEARFVETLL
VADASMAAFYGTDLQNHILTVMSMAARIYKHPSIRNSVNLVVVKVLIVEEEGWGPEVSDN
GGLTLRNFCSWQRRFNKPSDRHPEHYDTAILFTRQNFCGKGEQCDTLGMADVGTICDPDK
SCSVIKDEGLQAAYTLAHELGHVLSMPHDDSKPCVRLFGPMGKYHMMAPFFIHVNKTLPW
SPCSAVYLTELLDDGHGDCLLDAPTSVLPLPTGLPGHSTLYELDQQCKQIFGPDFRHCPN
TSVEDICVQLWCRHRDSDEPICHTKNGSLLWADGTPCGPGHLCLDGSCVLKEDVENPKAV
VDGDWGPWRPWGQCSRTCGGGIQFSNRECDNPMPQNGGRFCLGERVKYQSCNTEECPPNG
KSFREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFEAKVID
GTLCGPDTLSICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTACRKISGSFTPFSYGYN
DIVTIPAGATNIDVKQRSHPGVRNDGSYLALKTANGQYLLNGNLAISAIEQDILVKGTIL
KYSGSMATLERLQSFQALPEPLTVQLLTVSGEVFPPKVRYTFFVPNDMDFSVQNSKERAT
TNIIQSLPSAEWVLGDWSECPSTCRGSWQRRTVECRDPSGQASDTCDEALKPEDAKPCGS
QPCPL

>Gallus gallus_ADAMTS8(ENSGALP_2088)
HGQEGGSSPGAEDDSKRVVKRLSRKERHGEKPEAAPGQPLRRARRFVSEARYVETLLVAD
ASMVRFYGEDVENHILTLMSMAARIYKHPSLKNAISLVVVKVLVVDEEAAGPEVSDNGGL
TLRNFCSWQQQFNPLSDRHPEHYDTAILLTRQDFCGHQGCDTLGVADIGTMCDRNKSCSV
IEDEGLQAAYTLAHELGHVLSMPHDDSKTCERLFGPLGKHHMMAPLFVHLNKSQPWSPCS
AMYLTEFLDGGHGDCLLDPPAQALSLPSELPGRGALYSLDQQCQQIFGKDFQHCPNTTEE
DVCAQLWCRTSSGEPLCHTKNGSLPWADGTPCMAGGLCWDGACLPQDALQPQVLQPAVDG
GWGAWSPWGSCSRTCGGGVQFSHRHCDHPRPQHGGRYCEGQRTRYQSCHTEECPQDGKSF
REQQCEKYNSYNFTDLEGNRLEWVPKYAGVSPRDRCKLFCRARGRSEFKVFEPKVIDGTL
CGPETLSICVHGQCIKAGCDHVVGSSKKLDKCGVCGGNGSTCRKISGSLNRSKYGYNDIV
TIPAGATNIDIKQRSHRGVRHDGNYLALRTLEGRYLLNGDFAISAMEQDILIKGTILKYS
GSMTTLERLQSFRQLPEPLTVQLLTIASEVFPPKVKYTFFIPKDIPFSKQKDKEKKSANV
IRPMLTSQWVLGDWSECSKTCGSGWQRRTVECRDVEGQPSATCDRALKPEDIKPCGDVPC
PLWRMGPWSPCSQTCGEGVRTRNASCIHYTGTVIAPEKCSSPGPPPATATCLLRQC

>Danio rerio_ADAMTS8a(ENSDARP_62377)
MWSYLVIFVCLFAETSARLFETEEIVPVQLTGRSGGRVAKRSETQPSFRLSAFGRNFTLN
LTPDSTFISPALKVYRVKVKPQEKSTSNLTDLYQSLNQTEETGTEFLKGCFYTGFVDSSE
DSVVSVSLCRGILGSFISDGKEYLIEPKSFGLGTKGKLTEQLHVIKRRRFAKSSQVSKQL
SDMRADLQNSRIQMPSRRRRFVSTPRFIETLVVGDASLTHFYGDEIKHYMLTLMSVAAQV
YKHPSIKNSINIVLVKMLIVEDEEVGPSISSNGGVALRSFCAWQQLFNPSSHRHPEHYDT
AILFTREDICGHQSCETLGVADVGTMCDTKRSCSVIEDNGLQAAYTTAHELGHVLSMPHD
DTKSCEQLFGHLGEDHIMAPVFTQLSKTSPWSPCSALYVTEFFDNGHGDCLLDAPETTVA
LPTELPGLTYSLDRQCQQIFGEEFSHCPNTSSSEVCERLWCQQEGQSMCTTRNGSLPWAD
GTSCGTNRTCLNSVCMSSEDVLRPQPAVDGGWGEWGSWQPCSRSCGGGVMFSYRECNRPS
PQNGGKYCVGQRVNYQSCNKQACENNRGKSFREEQCEKYNNPNHFDIHGNVKQWIPKYAG
VSLRDRCKLFCRARGSSEFRVFAPKVIDGTPCGPDTTSFCVQGQCIKAGCDLEIDSSKKL
DKCAVCGGNGQSCRIISGSFNKVVHGYRDIVTIPSGATNINIKQQSHGSIPHDGHYLAVR
RENGNYILNGNFSVSTVEQHIPVLGAVLKYSGSSTTLERLQSFRQLQEPITIQLLSTAAE
SIPPKVKYTFYIPKSMAFSKPKDKKIAGKLIHPFGVPQWISSEWSECSKTCGSGWSRRNV
ECKDNAGFYSNHCNKDLRPSDIRPCADLPCPIWQIGPWSSCSQTCGHGERQRKILCIDYT
GKTVEPENCDPAKMPESVSEKCFYQEC

>Danio rerio_ADAMTS8b(ENSDARP_89072)
MVSTIVYVFFLVNLMSQFALCELNEEEETVLVNRTFRKGLFWRSEERQHFKLSAFGHLFL
LDLSPDSKFVSPVLNVQRIKAKNLRSVLDASRSGGALRDATLYPDSGADLRDCFYTGTVN
SEKESVVAVSLCHGIHGTFITQGVEYFIHPKASVQTTGKHFPQVHVIKRRAVSNSRTASL
VFDQMKVDSLVKESKLNSSEDEDSNMRRAKRFVSAARYIETLVVADASMTRFYGDEIKHY
LLTVMAMAAQVFVHPSLKNAVSLVVVKMVVVEDEEVGPELSSNGGVALRNFCMWQQLFNP
GSQRHPEHYDTAILFTREDICGYKDCDTLGVADVGTMCDPKRSCSVIEDNGLQAAFTVSH
ELGHVLSMPHDDSKNCEKWFGHLYGHTMAPFFVHLNKTLPWSPCSALYITEFFDNGHGDC
LLDPPEMTIPLAAELPGHTFGLDQQCQQAFGNKYTHCSNAPADQTCVQLWCREEGKIQCT
TRNGSLHWADGTPCGEDRRCREGLCLSSAMEEAGEQKVPVNGGWGEWGPWGPCSRTCGGG
VEFSHRECTSPVPQNGGLYCVGQRVKYQSCNTQTCPEDHGKSFREEQCEKYNSDRYMDIK
GNIKQWIPKYSGVSPRDRCKLVCRAKGSNEFKVFEAKVVDGTTCGPDTTSICVQGQCIKA
GCDQVIGSNEKLDKCSVCGGDGTTCRKISGSLNKATIGYIDIVTIPAGATNIDIKQRSHR
GIPHDGNYLAVKAQDGTYILNGNFSVSMAEQDVPVPGAMLRYSGSSTTLERLLSFHRLQE
PITIQLLSTAGDISPPRIKYTFFLPRDVPFSKPGTESRISTHVISPFGGFDWVLGEWSEC
SKSCGAGWSRRSVECRDGEGSLSYLCDADLRPADIRPCGDLPCP

>Tetraodon nigroviridis_ADAMTS8(ENSTNIP_17389)
LSAFGRNMTLNLVPDTSFLAPTFSVQRIRASGAAAAPNRSSELGEQLRACFYSGTVDAEA
DSLVAVSLCSGISGSFTTGGTEYLIRPQPHVLSRRTGPGSLRFRRFVSAPRFIETLVVAD
ASMAYFYGDEIQHYVLTLVSTAAQLYRHPSIKNRVSLVLVKMLVVEDAEAGPRLSANGGV
ALRNFCSWQQLFNPPSQRHPEHYDTAVLFTREDICGQKSCDTLGVADVGTMCDPKRSCSV
IEDNGLQDAFTAAHELGHVLSMPHDDSKTCEGLFGPLGGHHLMAPVLLSLDRTAPWSPCS
ALHITEFLDNGHGDCLLDVPHSAVALPAGLPGAAYSLDQQCQQVFGEEFLHCPNASDGAA
CSQLWCREDGTLQCSTRNGSLPWADGTPCGPDGTCLHGACTPTQEVMRPPVVVDGGWGAW
GAWRRCSRTCGGGVEFSHRECTDPEPQNGGKYCEGQRVQYRSCNTQACPGHSAKSFREEQ
CERYNSPAYLDHNGHVKEWIPKYAGVSPRDRCKLFCRARGSSEFKVFESKVIDGTACGPD
TTSVCVQGQCAKAGCDRVIGSSLRLDKCGECGGSGLSCRKITGLYNKVTYGYSDIVTIPA
GATNIDVKQRSHGGLKHDGNYLAVKSQSGGYILNGNYSVTTVEQDIPLPGAVLRYSGSST
TLERVQSFRQLREAVTVQLLSTAGDAVPAKVKYTFFIPRDAAFGRSGERTASSPSLYAVR
PVGVADWALGEWSACSKSCGSGWSRRTVECQDAAGFSSARCDPGLKPADLRACGDLPCPV
WQAGPWSACSPACGTGERRRGVLCVDYTGMPVEPDKCDPQKKPWPVSAQCHGNECL

>Homo sapiens_ADAMTS10(ENST_597188)
MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPP
PRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARP
HCLYAGHLQGQASSSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY
KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERY
VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPT
LEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT
LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM
AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCR
FQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFG
SRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDD
CPPGSQDFREVQCSEFDSIPFRGKFYKWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVD
GTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAG
YEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFQLRQ
GPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYSWHYAPWTKCSAQ
CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC
DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSC
GPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCG
VGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPL
VLKFQFCSRAYFRQMCCKTCHGH

>Mus musculus_ADAMTS10(ENSMUSP_84905)
MASACQILRWALALGLGLTFKVTHAFRSQDELLSSLESYEIAFPTRVDHNGAMLAFSPPA
FRRQRRGAGATTESRLFYKVAAPSTHFLLNLTRSPRLLAGHVSVEYWTREGLAWQRAARA
HCLYAGHLQGQAGSSHVAVSTCGGLHGLIVADDEEYLIEPLQGGPKGHRGPEESGPHVVY
KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNESERGQLGLKRSVSRERY
VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILLTEDQPT
LEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT
LGLAPVGGMCERERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLM
AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCR
FQHGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVCVPFG
SRPEGVDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTND
CPPGSQDFREMQCSEFDSVPFRGKFYTWKTYRGGGVKACSLTCLAEGFNFYTERAAAVVD
GTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPALPGTG
YEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGTTFHLRQ
GPDQAQSLEALGPINASLIIMVLAQAELPALHYRFNAPIARDALPPYSWHYAPWTKCSAQ
CAGGSQVQVVECRNQLDSSAVAPHYCSGHSKLPKRQRACNTEPCPPDWVVGNWSRCSRSC
DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACQGPMCPPEWATLDWSECTPSC
GPGLRHRVVLCKSADQRSTLPPGHCLPAAKPPSTMRCNLRRCPPARWVTSEWGECSTQCG
LGQQQRTVRCTSHTGQPSRECTEALRPSTMQQCEAKCDSVVPPGDGPEECKDVNKVAYCP
LVLKFQFCSRAYFRQMCCKTCQGR

>Gallus gallus_ADAMTS10(ENSGALP_2345)
MAIAWRLLIWTVTFTTTVCSFRGYMFQSQEEFLSSLDHYEIAFPIQVDQNGDFLTFDMRS
QLKQRPRRSLGSLPYEPSEQQVFYKVSAHRTQFLLNLTLHSNLLAEHFTVEYWKRDGVDW
QHDFHEDCHYAGHLQDQYLNSKVAISNCNGLHGVIVADEEEYFIEPLSPGANVSAGNEGK
GSPHVVYKRSSLQYPHMDAACGVLDEKPWKGRHWWLRTLKPSPLKPSGNHSQRGQLPLKR
SVSTERYVETLVVADKMMVGYHGRRDIEQYILAIMNIVAKLFQDSSLGNIVNILVTRLIL
LTEDQPTLEINHHAGKSLDSFCKWQKSIVNRNGNGNAIPENGIANHDTAVLITRYDICIY
KNKPCGTLGLAPVGGMCERERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGSRG
QETAKLMAAHITMKTNPFVWSTCSRDYITSFLDSGMGLCLNNAPPKQDFIYPTVAPGQAY
DADEQCRFQYGVKSRQCKYGEVCSELWCLSKSNRCITNSIPAAEGTICQTNTIEKGWCYK
RECVPFGTRPEGVDGAWGSWSSWGECSRTCGGGVSSSVRHCDSPRPTIGGKYCLGERKRY
RSCNTDDCPPGSQDFRELQCAEFDNVPFRGKYYTWKTYRGGGVKACSLNCLAEGFNFYTE
RAAAVVDGTPCRQDSNDICVNGECKHVGCDRVLGSDAKEDKCRVCGGDGSSCETIEGIFN
QSLPEGGYEEVIQIPKGSVHIDIRELNLSINYLALRGDAGEYYINGKLSIDPPRRFDIAG
TTFHYRRSPDEPESLEALGPTNVTLFVMVLVRTELQGIRYKFNAPISRDASNQYSWHYTP
WTKCSVLCAGGSQIQSVVCRKLSDSSTVSNHFCSPETKMLERQRPCNTEPCAPAWVIGNW
SECSRSCNEGVRTRSVFCKRKISATEEKTLDDASCTQPRPKMLEPCNNQTCPPEWVALDW
SECTPSCGPGFRHRIVLCKSGDHSATLPTSQCPEGSKPPTSMRCNLRRCPPPRWVTGEWG
ECSAHCGLGQQRRSVQCLAHTGQPSSDCLETLQPPGMQQCETKCESGPTDNPEECKDVNK
VAYCPLVLKFKFCSRTYFRQMCCKTCQGH

>Danio rerio_ADAMTS10(ENSDARP_99288)
METVWRSLACVGIMAMVASGGAESWSDEKFAQSQAEFLSSLGQYEIAIPVRVGPHGETLS
EEETSHGTVRHRRSTETQSAPEPQLYYQLSTSSTDLLLNLTLQGGLLSRQFRVEYWKRGR
LAWSHPYLPSCHYVGHLQHQPHSSSVALSNCNGLQGVIVAGGEEYLIEPLVSAKNLTNED
GREGRPHVVYKRSSLRYQNMDQSCGVIDEKPGKSYGWWQRTIKPSPNQMGRGQLPLKRSV
SRERFVETLVVADKMMVSYHGRRDIEQYILAVMNIVAKLFQDSSLGNAVNIVVTRLILLM
EDQPTLEVNHHAGKSLDSFCKWQKSILHRNGHGNAIPDNGIAHHDTAVLITRYDICIYKN
KPCGTLGLAPVGGMCEPERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNACGVRSQE
TAKLMAAHITMKTNPFVWSACSRDYITNFLDSGMGSCLNNVPPKQEFVYPTTAPGQAYDA
DEQCRFQYGVKSRQCKYGEVCSELWCMSKGNRCITSSIPAAEGTICQTSTIEKGWCYKRL
CVPYGTRPEGVDGGWGHWSPWEECSRTCGGGVSSSIRHCDSPRPTVGGKYCLGERKRFRS
CNIDECPVGSQDFREIQCSDFDSVPFRGKFYTWKPYRGGGVKSCSLNCLAEGYNFYTERA
PAVVDGTPCRDDSLDVCVNGECKHVGCDRILGSDVREDRCRVCGGDGSSCQVIEGVFNDS
LSEGGYEEVVRIPKGSVFIHIQELNISLNYLVLKSKGDQYFINGKLTIDTPRRFDIAGGT
FHYRRPANEPETLEALGPTNMTLIVMVLVREENPGILYRFNPPVSRDPLSSYSWHYTSWS
RCSALCAGGVQVQQVVCKKQADLSVVYNHFCDKKNKPKDKKRPCNQEPCPPTWWTGDWSE
CSRSCNGGVRTREVLCKRKMSVTEEKVLDDTACTTTRPSVTEPCNNHTCPPEWHALDWSE
CTPGCGPGYRYRVILCRSGDNGETLPESECPKQSRPTTRVRCNIQRCPPPQWVAGPWGEC
SARCGMGQEIRFVQCLTHTGQPSNECPESHRPAFMQQCKSKCDHSGPTDNPEECKDVNTV
AYCPLVLRFKFCGRAYFRQMCCKTCQGH

>Takifugu rubripes_ADAMTS10(ENSTRUP_16456)
METLWRTGLVCTVIAIVFATEVDGDHRDEFVQSQAAFLSSLGQYEIAIPVRIGPHGETLD
AEKSQHHQRRRRSAEDRLPDSVLSSLFYQLSTSRNNFLLNLTLQGGLLSRQFRVEYWKRG
RLAWSHPYSPHCHYVGHLQDQPHSSKVALSNCNGLQGVIVAGGEEYLIEPLVSPDNQTRM
EKGERAEGRPHVVYKRSSLRHQYKGQSCGVIDEKPMKSASWWQRTLKTPPHHVGRGQWPL
KRSVNRERYVETLVVADKMMVGYHGRRDIEQYILAVMNIVAKLFQDSSLGNAVNIVVTRL
ILLMEDQPTLEINHHAGKSLDSFCKWQKTIQHRNSYGNAIPDNGIAHHDTAVLITRYDIC
IQKNKPCETLGLAPVGGMCEPERSCSINEDIGLGTAFTIAHEIGHTFGMNHDGMGNACGP
HSQETAKLMADHITMKTNPFIWSACSRDYITSFLDSGMGSCLNNIPPKQEFVYPTTAPGQ
AYDADEQCRFQYGVRSRQCKYAEVCSELWCMSKSNRCITSSIPAAEGTICQTNTIEKGWC
YKRMCVAYGTRPEGVDGGWGLWSTWGECSRTCGGGVSSSIRHCDSPRPTIGGKYCLGERK
RFRSCNIDDCPAGSRDFREIQCSDFDGVPFRGKFYTWKPYRGGGVKPCSLNCLAEGYNFY
TERAPAVVDGTVCRDDSVDVCVNGECKHVGCDRVLGSDVREDRCRTCGGDGSSCVSVEGL
FNSSLPEGGYEEVVRIPKGSVFIHIQELNISLNYLVLKNKGDQYFINGNLSIDTPRRFNV
AGTTFHYRRPIDGPETLEALGPTNMSLIIMVLVREENPGVHYRFNPPLNRDPLTGFAWHY
TSWSRCSALCAGGVQTQQVVCMKHSDRTIVYNHFCDKKNRPKEKRRPCNTEPCSPSWGTG
EWSECSRSCNGGLRTRQVLCKRRISVTEEKVLDDSACSPLRPSLTEPCNNHSCPPEWLAL
DWSECTPSCGPGYRHRVVVCKSGESGDTLPESKCPKHSRPTSRVRCNLKRCPPPLWVTGP
WGECSAKCGLGQEMRSVQCLTHTGQLSNECLEHQRPASMQQCKSKCDLSLPVGTDNSEEC
KDVNTVAYCPLVLRFKFCSRPYFRQMCCKTCQGH

>Tetraodon nigroviridis_ADAMTS10(ENSTNIP_13061)
METLWRTGLVCTVVAIVFATEVAGGRRDEFVHSQAAFLSGLGQYDIAIPVRVGPHGETLA
AEKPQHHQRRRRSAEDRLPDSVRTSLFYQLSTSRNNFLLNLTLQGGLLSRQFRVEYWKRG
RLAWTHPYSPHCHYVGHLNDQPHSSKVALSNCNGLQGVIVAGGEEYLIEPLVSPDNQTGA
EKGERAEGRPHVVYKRSSLRHQYKGQSCGVIDEKPMKSASWWQRTLKRLPITSGRGQWPL
KRSVSRERYVETLVVADKMMVGYHGRRDIEQYILAVMNIVAKLFQDSSLGNAVNIVVTRL
ILLMEDQPTLEINHHAGKSLDSFCKWQKTIQHRSSYANAIPDNGIAHHDTAVLITRYDIC
IQKNKPCETLGGLAPVGGMCEPERSCSINEDIGLGTAFTIAHELGHTFGMNHDGMGNACG
PLSQETAKLMADHITMKTNPFIWSACSRDYITSFLDSGMGSCLNNVPPKQEFVYPTTAPG
QVYDADEQCRFQYGVRSRQCKYAEVCSELWCMSKSNRCITSSIPAAEGTICQTNTIEKGW
CYKRMCVAYGTRPEGVDGGWGLWSAWGECSRTCGGGVSSSIRHCDSPRPTIGGKYCLGER
KRFRSCNIDECPAGSRDFREIQCSDFDGVPFRGKFYTWKPYRGVGGVKPCSLNCLAEGYN
FYTERAPAVVDGTPCRDDSVDVCVNGECKHVGCDRVLGSDVREDRCRMCGGDGSGCVSVE
GLFNHSLPEGGYEEVVRIPKGSVFIHIQELNISLNYLVLKSKGDQFFINGNLSIDTPRRF
NVAGTTFYYRRPPDGPETLEALGPTNMSLIIMVLVREENPGVHYRFNPPLNRDPLAGFAW
HFTSWSRCSALCAGGVQTQQVVCMKHSDRTVAHNHFCDKKSRPKEKRRPCNTEPCSPSWW
TGEWSECSRSCNGGLRTRQVLCKRRLSVTEEKVLDDSACSPLRPALTEPCNNRSCPPEWL
ALDWSECTPSCGPGYRHRVVLCKSGESGDTLPESKCPKHSRPTSRVRCNLKRCPPPQWVT
GPWGECSAKCGLGQEMRAVQCLTHTGQLSNECLEHQRPASMQQCKSKCDLSLSVNADNSE
ECKDVNTVAYCPLVLRFKFCSRPYFRQMCCKTCQGH

>Gasterosteus aculeatus_ADAMTS10(ENSGACP_10156)
RLAAFLSNLGRYEIAIPVRVGPNGEALDTETQPHHRRRSRSTEDGLPDSLFYQLSTSRNN
FLLNLTLQGGLLSRQFRVEYWKKGRLAWSHPYSPHCHYVGHLQDQPHSSKVALSNCNGLQ
GVIVAGGEEYLIEPLVSPDNQTRTEKGEGAEGRPHVVYKRSSLRHQYKGQSCGVIDEKPL
KGASWWQRTLKTPPHHVGRGQLPLKRSVSRERYVETLVVADKMMVGYHGRRDIEQYILAV
MNIVAKLFQDSSLGNAVNIVVTRLILLMEDQPTLEINHHAGKSLDSFCKWQKNIQHRSSY
GNAIPDNGIAHHDTAVLITRYDICIQKNKPCETLGLAPVGGMCEPERSCSINEDIGLGTA
FTIAHEIGHTFGMNHDGMGNACGPRSQETAKLMADHITMKTNPFIWSACSRDYITSFLDS
GMGSCLNNVPPKQEFVYPTTAPGQAYDADEQCRFQYGVRSRQCKYAEVCSELWCMSKSNR
CITSSIPAAEGTICQTNTIEKGWCYKRVCVAYGTRPEGVDGGWGLWSPWEECSRTCGGGV
SSSIRHCDSPRPTIGGKYCLGERKRFRSCNIDECPAGSRDFRIIQCSNFDSVPFRGKFYT
WKPYRGAGGVKPCSLNCLAEGYNFYTERAPAVVDGTPCRDDSLDVCVNGECKHVGCDRVL
GSDVREDRCRVCGGDGSSCVSVEGLFNDSLPEGGYEEVVRIPKGSVFIHLQELNISLNYL
VLKSKGDQYFINGKLTIDTPRRFNVAGTTFHYRRPTDGPETLEALGPTNITLIVMVLVRE
ENPGIHYRFNPPMNREPLTGFAWHYTSWSRCSALCAGGVQTQQVVCRKQADHSVVYNHFC
DKKNKPKEKRRSCNTEPCSSSWWTGEWSDCSRSCNSGLQTREVLCKRRISVTEEKVLDDS
ACTNPRPSLTEPCSNQSCPPEWLALDWSECTPSCGPGYRHRVVLCKRGESGDNLPDSKCS
KHGRPTSRVRCNLQRCPPPQWVTGPWGECSARCGLGQEMRSVQCLTPNGQPSNECLEHQR
PSAMQQCKSKCDLSLPISTDNPEECKDVNTVAYCPLVLRFKFCSRPYFRQMCCKTCQGH

>Oryzias latipes_ADAMTS10(ENSORLP_11481)
METLWRTGLACTVIIIMVASEVAEGRRDDFAQSQAAFLSNLGQYEIATPVRVGPNGEKFD
GDNSHHQRRRRSPEDRLHDTLFYQLSMSQNNFLLNLTLQGGLLSHQFRVEYWKRGQLAWS
HPYSPHCHYTGHLQDQPHSSKVALSNCNGLQGVIVTGGEEYLIEPLVSPDNQTKTEGSER
TEERPHVVYKRSSLRHQYKGRSCGVIDEKPLKSLSWWQRTLKTPPHLVGRGQLPLKRSVS
QERYVETLVVADKMMVGYHGRRDIEQYILAVMNIVAKLFQDSSLGNAVNIVVTRLILLME
DQPTLEINHHAGKSLDSFCKWQKSIQHRNSYGNAIPDNGIAHHDTAVLITRYDICIQKNK
PCETLGLAPVGGMCEPERSCSINEDIGLGTAFTIAHEIGHTFGMNHDGMGNTCGPRSQET
AKLMADHITMKTNPFIWSACSRDYITSFLDSGMGSCLNNVPLKQEFVYPTTAPGQAYDAD
EQCRFQYGIRSRQCKYSEVCSELWCMSKSNRCITSSIPAAEGTICQTNTIEKGWCYKRMC
VAYGTRPEGVDGGWSLWSPWGECSRTCGGGVSSSVRHCDSPRPTIGGKYCLGERKRFRSC
NIDECPAGSRDFREIQCSDFDNIPFRGKFYTWKPYRGGGVKPCSLNCLAEGYNFYTERAP
AVVDGTPCRDESLDMCVSGECKHVGCDRVLGSDVREDRCRICGGDGSSCVSVEGVFNDSL
PEGGYEEVVRIPKGSVFIHIQELNMSLNYLVLKSKSDQYFINGKLTIDTPRRFNVAGTTF
HYRRPTDGPETLEALGPTNITLIVMVLVREENPGIHYRFNPPLNRDPLNGFSWFYTSWSR
CSVLCAGGVQIQQVVCKRLLDHTVVYNHFCDKKSKPKEKRRSCNTEPCSPTWWTGGWSEC
SRSCNGGLRTREVLCKRRISVTEEKILDDSACSSHRPSLTEPCNNHSCPPEWLALDWSEC
TPSCGPGYRHRVVLCKSGESGDILSESRCPKHGRPTSRVRCNLKRCPPPQWIVGPWGECS
AKCGLGQEMRLVQCLTHTGQPSNECLDHQRPAAMQQCRSKCDLNLPISTENTEECKDVNT
VAYCPLVLRFKFCSRPYFRQMCCKTCQGH

>Homo sapiens_ADAMTS14(ENST_373208)
MAPLRALLSYLLPLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGP
AAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLR
LRPNRRLVVPGSSVEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRT
DSTDFFIEPLERGQQEKEASGRTHVVYRREAVQQEWAEPDGDLHNEAFGLGDLPNLLGLV
GDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESL
GVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLT
RQDFGPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD
ETSLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYS
MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFK
GHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFE
YQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGD
VVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVK
GTLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRT
FTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIG
SNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPI
RRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP
EARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCS
LPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLD
RYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKP
TGSEDHQHGRATQLPGALDTSSPGTQHPFAPETPIPGASWSISPTTPGGLPWGWTQTPTP
VPEDKGQPGEDLRHPGTSLPAASPVT

>Mus musculus_ADAMTS14(ENSMUSP_112723)
MAWLRALLHCLLPWYCALCAAAGSQTPDLRLSGKLHDYVVTVPCSTDFQGRFLSHVVSAP
AAPSPRSHLRVARSPLSLERETPRPGGPRQHFLYFNVTVFGKLLHLRLQPNRRLVAPGAP
VEWQEDFRELFRQPLQQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDNSDYFIEPLERG
QQEKEAGGRTHVVYRREAVQREWKEPHGDLHNEAFGLGDLPNVLDLVGDRLGDAERKRRH
AKPGSYSIEVLLAVDDSVVRFHGREHTQNYVLTLMNIVDEIYHDESLGAHVNIALVRLIM
VGYRQSLSLIERGNPARSLEQVCRWAHSQQRQDPSHTEHHDHVIFLTRQNFGPSGMQGYA
PVTGMCHPLRSCALNHEDGFSSAFVVAHETGHVLGMEHDGQGNGCDDETSLGSVMAPLVQ
AAFHRFHWSRCSKLELSRYLPSYDCLLDDPFERTWPQPPELPGIDYSMDEQCRFDFGTGY
HTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYG
QDGGWSSWTNFGSCSRSCGGGVRSRSRSCDNPPPAYGGRPCSGSMFEYQICNSEDCPGPY
EDFRAQQCAKRNSYYTHQDAKHSWLPYEPDSDAQKCELICQSADTGDVVFMNQVVHDGTR
CSYRDPYSVCARGECVPFGCDKEVGSMKTDDKCGVCGGDNSHCRTVKGTLGKGSKQAAAL
KQVQIPAGARHIQIELLEKAPHRIAVKNQVTGSFIFNPKGKEASSRTFTALGLEWEHEAE
DTKDSLRTNGPLPEAIAILVLPPAEGKPRGSLAYKYVIHEDLLPLIGSNNVLLEETDTYE
WALKSWSPCSKACGGGIQFTKYGCRRRRDHHMVHRHLCDHKKRPKPIRRRCNQHSCPQPT
WVTEEWGACSRSCGKLGLQTRGVQCLLPLSNGTHKAMPAKACLGNRPEAKKPCLRVPCPA
QWRTGAWSQCSATCGEGIQQRQVVCRNTSSALGPCEGVKPDMVQICSLPACGGDLQNSTV
KAEVQDPVTKTGYREPQSRPLTPEDRISTMEPCVRDRSVFCRMEVLDRYCTIPGYHRLCC
ESCIKKTSGPNASLALPPTFSTPGSLLPAPKATLEDVKSTRGPTSLEDHRQSQPTQLPDV
ADRISPVTQYPVTPQMLSPKAFPGNSPATPRRPPQDWTQTAMPTSEGQGQSREEPGHGGT
SLPATSPVT

>Dasypus novemcinctus_ADAMTS14(ENSDNOP_14855)
MALLGALLSCLLPLHCALRAATAAGSRTPAELHLSGKLQDFVVTVPCSTDVQGRFLSHVV
SGPAAASAGREAVGRPPTPPSRSSPRRVARSPPRPEEGTPPPGRAGRTSLYFNVTIFGKE
LHLRLRPNRRLVVPGASVEWQEDFRELFRQPLQQECVYTGSVTGMPRAAVAISNCDGLAG
LIRTDSTDYFIEPLERGQQEKEASGRTHVVYRRGEGGRLQWEEPHRDFHNEAFGLGGLPN
LLGLVEERLGEAERKRRHAKPGSYSIEVLLAVDDSVVRFHGRRHVQNYVLTLMNIVDEIY
HDESLGVHINIALVRLIMVGYRQSLSLIERGNRSASSSTPCLPRWPRARDSLDSSSPCYQ
HHLVVSARQPSRPAGYAPVTGMCHPLRSCALNHEDGFSSAFVVAHETGHVLGMEHDGQGN
GCADETSLGSVMAPLVQAAFHRFHWSRCSRLELGRYLPSYACLLDDPFEPTWPRPPELPG
VDYSMDEQCRFDFGTGYQTCSAFQTHEPCRQLWCSHPDNPYFCKTKKGPPLDGTECAPGK
WCFKGHCIWKSLEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCDYPPPAYGGRPCSG
PMFEYQVCNSEECPGPHEDFRAQQCAKRNSYYTHRNAKHSWLPYEPDDDAQKCELICRSA
DTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHC
RTVKGTLGKAPKQAGALKMVQIPAGARHIQIEALDKVPHHVVVKNQVTGSVILNPKGKEA
TSLNFTAMGLEWAYTVEDAKESLETSGPLPEAIAVLVLPPGDSGPRSSLAYKYVIHEDLL
PLIGSNNVLLEETDTFEWALKSWAPCTKACGGGVQFTKYGCRRRRDHHMVQRHLCDPRKR
PKPIRRRCNQHACAPPAWVTEEWGACSRSCGKLGVQTRLVQCLLPLSNGTRKALLATACP
GDRPEARRPCLRVPCPAQWRTGAWSQCSATCGEGIQQRQVVCRTSANSLGQCDGDKPDSV
QVCSLPACEGGLQNSTAEDDVRKLVTPEGQWAPQSGPLPPINKVSSMEPCRGDRSIFCQM
KALGRYCSIPGYHRLCCGSCTGKVPASDASLDPGLASPPPITTPGSLSAGPKAPPDAVAP
TRGLAGPAGHRQDLTTQLPEPLDRSSAVTQSRFAPRKPSPGAFWGTFPPTLWGLPQASTA
APMPGSQDTGQPREGRELPGTKLPTPPP

>Homo sapiens_ADAMTS15(ENST_299164)
MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF
QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC
GGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGW
NPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH
YLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLN
KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA
HELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG
DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVC
QTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLAR
RQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLA
VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCD
GNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI
GDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT
VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP
ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELS
AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC

>Mus musculus_ADAMTS15(ENSMUSP_67022)
MLLLGISILALAWRPAGSSEPEWEVVVPIRRDPDINGRHYYRRGTEDSGDQGLIFQITAF
QQDFYLHLTPDAQFLAPAFATEYLGVPLQRLTGSSLDLRRCFYSGYVNAEPDSFAAVSLC
GGLRGAFGYRGAEYVISPLPNTSAPEAQRHSQGAHLLQRRGAPVGPSGDPTSRCGVASGW
NPAILRALDPYKPRRTGAGESHNRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH
YLLTLLATAARLYRHPSILNPINIVVVKVLLLGDRDTGPKVTGNAALTLRNFCAWQKKLN
KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA
HELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG
DCLLDQPSKPITLPEDLPGTSYSLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVC
QTRHFPWADGTSCGEGKFCLKGACVERHNPNKYRVDGSWAKWEPYGSCSRTCGGGVQLAR
RQCSNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLA
VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCTPDSTSVCVQGKCIKAGCD
GNLGSKKKFDKCGVCGGDNKSCKRVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI
GDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSVLRYSGTGTAVESLQASRPILEPLT
VEVLSVGKMTPPRVRYSFYLPKEPREDKSTRPKDPRGSPVLRNSVLSLSNQVEQPDNRPP
ARWVAGSWGPCSVSCGSGLQKRAVDCRDSPGQQGASACDVDHRPLEKRACGEPCPTWELG
NWSPCSKSCGRGFKRRPLKCVGHGGRLLARDQCDLRRKPQELDFCVLRPC

>Dasypus novemcinctus_ADAMTS15(ENSDNOP_11435)
MLLLGILTLALAGRPAGGSEPEQEVVVPLRLDPDINGRRYYRRGPEDSAAQGLIFQITAF
QEDFYLHLTPDAQFLAPAVTTERLGVPLQGLSRSAQDLRRCFFSGDVNAEPDSFAALSLC
RGLRGAFGYRGAEYVISPLPNASAPGAQRNGLGAHLLQRRGAAGRPPRDPTSRCGVSSGW
NPDILRALDSYKPRLTGSGDGRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH
YLLTLLATAARLYRHPSILNPISIVVVKVLLLGSRETGPKVTGNAALTLRNFCAWQKKLN
KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA
HELGHVFNMPHDNVRVCEEVFGKLQANHMMSPTLIQIDRDRPWSACSAAIITDFLDSGHG
DCLLDQPSQAIALPEDLPGASYPLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGHMVC
QTRHFPWADGTGCGEGKFCLKGACVERHDPNKYRVDGAWAKWEPYGPCSRTCGGGVQLAR
RQCSSPAPANGGRYCEGVRVKYRSCSLEPCPSSASGKSFREEQCEAFNGYNHNTNRLTLT
VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTPCTPDSTSVCVQGKCIKAGCD
GNLGSKKKFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI
GDDNYLALRNGQGKYLLNGHFIVSAVERDLVVKGSVLHYSGTGTAVESLQASRPILEPLT
VELLSVGKMTPPRVRYSFYLPKEPREDRPSPRLDPRAPSVPRHSELSLSNQVEQADHRPP
ARWVAGSWGPCS

>Xenopus tropicalis_ADAMTS15(ENSXETP_47272)
QSFLHLSNAKLCLALEICLFKEVVVIPKRLDPDLNGRYYLKKENDNAKDLGVIFQITAFY
EDFYLNLIPDAQFIAPAFSMHFPGSIPKQSPDLRHCFYSGDVNSDRDSFAALSLCGGLRG
AFGYQGEEYLIRPLQNVTRDQLQSSHQGPHLLQRRKGPLKSVDTTSRCGVGSGLNQGIME
ALNKYKGSHNKKQLNGTRLKGSHRSRRFASITRYVETLIVADETMLKFHGDDLQHYLLTL
MATAARLYRHPSIQNPINIVVVKFMVLTDDGKGPKVTTNAAMTLRSFCGWQKKWNKVSDK
HPEYWDTAILFTKMDLCGASTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGH
VFNMPHDNVKVCEEAFGKLRENYMMSPTLIQIDRANPWSACSAAIITDFLDSGHGECLLD
EPAKPISLPEELPGARYSLSRQCELAFGLGSKPCPYMQYCTKLWCTGRARGQLVCQTRHF
PWADGTSCGDGKFCLNGACVERHNVNRYKAKVDGAWGKWSPYGQCSRTCGGGVQLAKREC
NNPEPSNGGSFCEGLRVKYRSCSLNPCPETECKSFREEQCESFNGFNHSTNRITQTVGWV
PKYSGVSPRDKCKLICRANGTGYFYVLSPKVVDGTPCSPDATSVCVQGKCIKAGCDGQLG
SKKKYDKCRVCGGDNKSCKKISGLFTKPIHGYNFVVTIPAGASNLDVRQRGYKGLINDDN
YLAVKNAQGRYLLNGNYIVAAGERDISVRGSLLKYSGTGTAVETLQAINVIQESLTIEVL
CVGKMTPPRLRYSFYIPREKKDGKVGQVISNSLAGLPPPLPRLKPQSNWIAGNWGDCSVS
CGTGHQIRTIECRDPWEQLASDCQAALRPSERRTCGDPCPVWDAGEWSSCSKSCGRGFKR
RQLRCSADGGVTLPREHCHLKRKPQELDFCNIRPC

>Danio rerio_ADAMTS15(ENSDARP_89066)
MFLLLRSVLLVNVFYAQWRIVNSMQSQLCVPIRMDHVKNSLVDDEDSILPRKAVFKISAF
EQDFVLELRSDSSFIAPGFSARTDSAAHNSAHGEDLSRCFYAGEVNSDPYSYAALSLCKG
LQGAFGYDGWEYFIKPASNNTDRDNEAAHLIRRRSNADLSGNSTSRCGVDSNATQTVAQS
LAKFKHLKEQHMNNVTMSFLRNRSKRFVSIPRYVETLVVADESMAKFHGDDLKHYVLTLM
SVAAKLYKHPTILNSINIVVVKFMVINEEEKGPKVSGNAAMTLRNFCTWQKKLNKNNDKH
PEYWDTAILFTKQDLCGSSTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHV
FNMPHDNVKACEEVFGKLQDNHMMSPTLIRINRTSPWSPCSAAIITDYLDSGHGDCLLDQ
PEKPLALPDVLPGASYGLERQCELAFGAGSKPCPFMQAPCQRLWCTGKTRGQLVCQTRHF
PWADGTSCGDGQLCMRGTCIDKQELLKTKVDGKWGKWGPFGSCSRTCGGGVQLSKRECDN
PVPVNGGKYCQGVRVKYRSCNLSPCPDTVGKSYREEQCEAYNGFSLNTNRLTSSVVWVPK
YSGVSAKDMCKLICRANGTGYFYVLAPKVVDGTPCSPDSSSVCVQGKCIKAGCDGKLGSN
KKSDKCGVCGGDNKNCKKVSGLFTKPMHGYNFVVMLPMGSSNIDIRQRGYKGITSDDNYL
AVKNNQGKYLLNGNYVVSAMEKDILVKGSLLRYSGTVGSSETLQAVKPLGEALIIEVLSV
GQMTPPRIRYSFYLPRESKDNKAQKKEEKARAENSILREEDIASKPGKWVAAGWDVCSVT
CGNGLQRRMVQCLGGDGGPGVDCEPSQKPSAIQACGDPCPMWDVGDWSPCSKTCGKGFKR
RLLRCITTVGKLLPREKCVDKKKPQELDFCSLAPC

>Takifugu rubripes_ADAMTS15(ENSTRUP_30346)
MVPLVGALLILTKLLLCCGPVRCLEVDFCSPQRADEHPQGRAEQAGDGGVVFKLRAFTRD
LYLRLTPDSGFLAPPESRAAASAASDLRDCFYSGDVNADPDSFAALSLCGGLSGGFSYDG
MEYFISPGGSARAAPGDPAERTHVISRRGRVDPGGSATRRCGVAPGGNFSASLERYRHLS
ETVLGGAGRSRRFASIPRFVEVLVVADESMASAHGEDLQHYLLTLMSVVARLYKHPSILN
PISVVVVGVMVLGGADKGPKVSSNAALTLRNFCSWQKKLNKHSDKHPDYWDTAVLFTKQD
LCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPTAFTAAHELGHVFNMPHDNVKACEEV
FGKLKDNHMMSPTLIQIDRSRPWSVCSAAIITEFLDRGHGECLLDPPQKQLSLPNNLPGF
SYNLHRQCQLAFGPGSKPCPFMQPCSKLWCTGKAQGQLVCQTRHFPWADGTGCGDGRVCH
RGSCTAKNSTAQAKIQVNGRWGAWSPYAGCSRSCGGGVELAKRECNSPTPENGGKYCYGL
RVKYRSCNLNPCPDAAPGKSFREQQCEEFNGMNLNTNRLGSSVVWVPKYSGISHKDQCKL
ICRANGTGYFYVLAPKVVDGTPCSPDTPSVCVQGKCIKAGCEGKLNSRKKFDKCGVCGGN
NQGCTKVSGMFTKPIHGYNFVVTLPVGAANIDVRQRGYQGMMSDENYLAVRNRHGEYILN
GNYVVSAAERDLLVRGSLVRYSGTSSSVETLQAVMPLKEPLTVEVLSVGKMTPPRVRYTF
YVSKESKEEKVLRKEERSHNRILEGGNKVEPKMGKRPVSHWVAGGWESCTVTCGSGLQRR
PVLCQSADKRAAMDCDSAERPQSERACGDPCPMWTIGTWSHCSKSCGRGFKRRQVRCETG
KGVNLPREHCSWKRKPQELDLCYLRTC

>Tetraodon nigroviridis_ADAMTS15(ENSTNIP_3233)
METELCYPVEMDDRNQDRKDFQNDVENLHGKHVLKIRAFQQELVLDLHQDFSFIAPSVAN
QDKFWSPDGDDTADLSRCFYSGYVNSDRESYAALSLCKGLRGAFGFQGWEYFISPVQNRS
TESAHIIRRRTNSNQKLNSTSRCAVDSDLSLKAAKSLAKYKHLEDGSNVTETVLRKIGRA
KRFASVPRYVETLVVADSSMVQFHGSDLKHYLLTLMSVAARLYKHPSILNFINIAVVKIV
IISEEDKGPKVSGNAAMTLRNFCTWQKKLNKNTDKHPEYWDTAILFTRQDLCGASTCDTL
GMADVGTMCDSKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKACADVFGKLQDNHMM
SPTLIQINRTSPWSPCSAAIITEFLDSGHGECLLDQPQKPLVLPDVQPGASYGIDRQCEL
AFGEGSKPCPFIQPPCGRLWCTGKSNGHLVCMTRHFPWADGTQCGNDQVCEQGICSDRQL
QNAKVDGRWGKWGQFGSCSRTCGGGVQLSRRECNNPVPSNGGKYCQGVRVKYRSCNLNHC
PDKGRTFREEQCERSGLNFSNNRIAPFMVWVPKYSGVSSDDRCKLICRANGTGYFYVLAS
KVQLWDGTPCSPDSTGVCVQGKCIKAGCDGKIGSDKKFDKCGICGGDNKGCKKVSGLFTK
PVHGYNFVVMLPVGAANIDIRQRGYKGMTSDDNYLAVKNSDGRYLLNGNYIVSAGERDII
VKKSLLRYSGTTGLSETLQSVKPLEEALTVEVLCAGQITPPRIRYSFYLSRQNKEDKNLK
KEAHDNSPNSVLAHDGAKENGAKLLKKSYNKENPAPGKWISAVWDKCSVTCGNGLQRRSV
QCLKPDGKPATDCDSSQQPSDTRVCGTPCPEWLIGQWSPCSRTCGKGFKRRPLHCKTQSG
HSLPRDRCTGLQKPQELDFCNLRSC

>Gasterosteus aculeatus_ADAMTS15a(ENSGACP_45)
FRFSAFERVLHLRLAPDSSFLALPGAADLRECFFSGTVNADPDSFAALSLCEGLRGFSYD
GMEYFIRPTDTADAEHRNSFNRTHVIHRWTRAAHSGANHTSRCAVTPDANFNGSFENREH
LDGLAATVVKNLGRSKRFASIPRFVEVLVVADESMAAFHGGDLKHYLMTLMAVAARLYKH
PSILNSINVVVVDFMVINEADKGPKISSNAALTLRNFCSWQKKLNKHNDKHPEYWDTAIL
FTKQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTAAHELGHVFNMPHDNVK
ACEEVFGKLKDNHMMSPTLIQIDRSRPWSACSAAIITQFLDRGHGDCLLDQPQKQLSFSD
HMPGSSYSLHRQCELAFGPGSKPCPYMQPCTKLWCTGKARGQLVCQTRHFPWADGTSCGH
GKVCYRGACTDKNNTVHVKVDGRWGKWGAFGSCSRSCGGGVQLASRQCDNPVPQNGGRYC
YGLRIKYCSCNLNTCPKKAPGKSFREEQCEAFNGLSLNTNRLGSTVAWVPKYSGISPKDK
CKLICRANGTGYFYVLAPKVVDGTLCSPDTSAVCVQGKCIKAGCDGKLDSSRKFDKCGVC
GGDNQGCKKVSGMFTKPVHGYNFVATLPVGASNIDVRQRGYRGMVSDENYLAVKNRHGKY
LLNGNYVVSAVERDLLVKGALLRYSGTSSAVEILQSTRPLQEALTVEVLSVGKMTPPRVR
YSFYIAKDSKEDKTLRKEDKSHAAHNSVLADSNQVEAEELMASKRPVSHWVTGSWDPCTV
TCGSGLQKRPVHCQSTEGRPAADCSAADRPASARACGDPCPAWDAGGWSQCSKSCGRGFK
RRPVRCMTENGPSLPRDHCSGRRKPQELDLCNLKPC

>Gasterosteus aculeatus_ADAMTS15b(ENSGACP_26992)
METELCFPIRLDNHKHNRGDFDNDVEILNGKCVFKIRAFQQEFVIELHQDSNFIAPSISN
QDEFWLSNTDVTSDLRWCFYSGYVHADPHSYAALSLCKGLHGAFGFQGWEYFIAPVQNDT
TTAEGAHIIRRRTSNNLKLNSTSRCAVDTGISLQVARSLEKYKRLQDHDNVTETLLKKMG
RTKRFASIPRYVEALVVADESMVQFHGEDLNHYLLTLMSVAAKLYKHPSILNSINIVVVK
IVVISEEDKGPKVSGNAAMTLRNFCTWQKKMNHNNDKQRDYWDTAILFTRQDLCGASTCD
TLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVRACEDVFGKLQDNH
MMSPTLIQINRTSPWSLCSAAIITEFLDSGHGECLLDHPQKPLFLPDVMPGTSYVLERQC
ELAFGEDSKPCPFMQPPCGRLWCTGKSNGHLVCMTRHFPWADGTHCGDNQVCNQGVCSNK
QVPRVKVDGRWGRWGPFGSCSRTCGGGVQLSKRECSNPVPSNGGKYCQGVRVKYRSCSPN
QCTETGVGKTYREEQCASTGRSFNSNRIDPSVVWVPKYSGVSTDDRCKLICRANGTGYFY
VLAPKVVDGTPCSPDSTGVCVQGKCIKAGCDGKIGSTKKFDKCGICGGDSKGCKKVSGLF
TKPEHGYNFVVMLPLGAANIDIRQRGYKGMRSDDNYLAVKNSQGHYLLNGNYIVSAGERD
IIIKNSLLRYSGTAGLAETLQAVKPLGESLTVEVLCAGKMTPPRIRYSFYLARQAKEEKV
KKEERVNSHNSVLSEDSVKENGGDTLKKSYSKEEPSLGKWISTGWDQCSVSCGVGFQRRM
VQCLSADEKPWLDCDPSQRPPATRVCGDPCPDWHIGQWSPCSRTCGKGFKRRPLHCKNGQ
SGHLLPRDHCAGLRKPQELDFCNRMPC

>Oryzias latipes_ADAMTS15a(ENSORLP_19045)
RLLLILVHLFLHWRASDCMEVDICVPVRVAHLHHGKHERTDRARDAQVAFKLSVFKQDFF
LHLAPDPTFHALDGPPPARTRPCFYAGHVNADPDSLAALSICGGLRGAFSIDGVEYFIAP
QRGDPQERIHVITRRGSRAHERSRCGVSPDSNLTLSLQKYSHMKELYSNGLRRDFWGSLG
RSRRFASTPRYVEVLVVADESMAKFHGDDLQHYLLTLMSVAARLYKHPSILNPINIVVVG
FMVIHEAHKGPKVSSNAALTLRNFCSWQKKLNKYSDQHPEYWDTAILFTKQDLCGASTCD
TLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHIFNMPHDNVKACEEVFGKLKDDH
MMSPTLIQINRSRPWSVCSAAIITEFLDRGHGDCLLDQPQKQMALLESLPGSSYSLHRQC
ELAFGPGSKPCPYMQSCSKLWCTGKARGQLVCQTRHFPWADGTSCGPEKVCYRSACVHKN
TTVRVKVDGHWGKWGAFGDCSRSCGGGVQLAKRECNNPAPEHGGKYCYGLRLKYRSCNFS
PCPKTGMGKSFREEQCEAYNGFNLNTSRLGSTVVWVPKYSGISPKDKCKLICRANGTGYF
YVLSPKVVDGTPCSPDTSAICVQGKCIKAGCDGKLESNKKFDKCGMCGGENQGCKKVSGM
FTKPVHGYNFVVTLPVGASNVDVRQRGYRGMVGDENYLAVKNSHGKYLLNGNYVVSAVER
DLLVQGSLLRYSGTSTSVEMLQAVRPLQEPLTVEVLSVGNMTPPRIRYSYYISKESKVEK
TLWKEEKSHKAHNSILVDSNKIETKKQIMARKPASHWISGSWDLCSVSCGNGLQRRLVQC
KSVEGLPAGNCEGAERPAAVRVCGDPCPVWDVGSWSHCSKSCGRGFKRRLVRCMTDNGLN
LPREHCFGKRKPQELDLCNLMPC

>Oryzias latipes_ADAMTS15b(ENSORLP_9505)
VIKIRAFQQELMINLNQDSHFIGPSSIDASWLPNTKSRADLSRCFYSGYVNDDPYSYAAL
SICKGLHGAFDFQGWEYFINPARNDTKSAEEAHIIQRRTSNNLRNSSASRCAVKSDLSHQ
EVQSLIKFKRLADHSNLTESMLKRRAKRFASIPRYVETLVVADASMAQFHGDDLKHYLLT
LMSVAAQLYKHPSILNSISIVVVKIMILSEEDKGPKVSSNAALTLRNFCTWQKKMNKNND
KHPDYWDTAILFTRQDLCGASTCDTLGLADVGTMCDPKRSCSVIEDDGLPSAFTAAHELE
GHVFNMPHDNVRACEDVFGKLQDNHMMSPTLVKMNRTSPWSPCSAAIITEFLDSGHGECL
LDQPQKQLVLPDGLPGASYDLNRQCELAFGEDSKPCIAMQPCSRLWCTGTSSSHLVCMTR
HFPWADGTECGDGKVCDRGVCSEKPAKKMTVDGRWGSWSLFGSCSRSCGGGIQLSKRECT
NPAPSNGGKYCRGLRVKYRSCNLNSCTDAVTEKTFREEQCETSGRNFNSNHVSQSVVWVP
KYSGVSLGDRCKLVCRANGTGYFYVLAPKVIDGTPCSPDSTGVCVQGKCIKAGCDGKIGS
NKKFDKCGICGGDNKGCKKVSGLFTKPVHGYNFVVMLPEGAANIDIRQRGYKGMRGDENY
LAVKNSKGRYLLNGNYVVSAGEKDILVKHTLLRYSGTSGLSETLQTVKPLGESLTVEVLC
AGKMTPPRIRYSFYLPRQTKDHKTLTKHPSGHNSVLDQNSYIEESTAGKWVPTSWEKCSV
TCGDGVQKRSVQCLGPDGKPGLDCDPLQIPSETKVCGDVCSEWHVGQWSPCSRTCGKGFK
RRPLLCKSQTGKLLARDHCTGIRKPQELDFCNLKPC

>Homo sapiens_ADAMTS16(ENST_274181)
MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEY
DLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVA
PGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL
RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRL
GLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDK
KMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH
TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTIN
EDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLH
KFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKA
LWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSR
TCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRF
RGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERV
GCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMN
VSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIV
ELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDL
KFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHY
DSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSA
RAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAE
KYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTA
SCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAEKKDAFCKDYFHWCYLV
PQHGMCSHKFYGKQCCKTCSKSNL

>Mus musculus_ADAMTS16(ENSMUSP_79041)
MESRGCAALWVLLLAQVSEQQTPACALGLAAAASGSPEDPQPPPFSGSSWLETGEYDLVS
AYEVDHRGDYVSHDIMHYQRRRRRRAVTQPGGDALHLRLKGPRHDLHLDLKAASNLMAPG
FMVQTLGKGGTKSVQMFPPEENCFYQGSLRSQGNSSVALSTCQGLLGMIRTKDTDYFLKP
LPPHLTSKLNRSAQGDSPSHVLYKRSTERQAPRENEVLMITRKRDLARPHLHHDNFHLGP
SQKQHFCGRRKKYMPQPPNDDLYILPDEYKPSSRHKRSLLKSHRNEELNVETLVVVDRKM
MQSHGHENITTYVLTILNMVSALFKDGTIGGNINIVIVGLILLEDEQPGLAISHHADHTL
TSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTVNED
SGLGLAFTIAHESGHNFGMVHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSSCSRQYLHKF
LSTAQAICLADQPKPVKEYKYPEKLPGQLYDANTQCKWQFGEKAKLCMLDFRKDICKALW
CHRIGRKCETKFMPAAEGTLCGQDMWCRGGQCVKYGDEGPKPTHGHWSDWSPWSPCSRTC
GGGISHRDRLCTNPRPSHGGKFCQGSTRTLKLCNSQRCPLDSVDFRAAQCAEYNSKRFRG
WLYKWKPYTQLEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGMCERVGC
DNVLGSDATEDSCGVCKGNNSDCVTHRGLYSKHHSTNQYYHMVTIPSGARSIHIYETNIS
TSYISVRNSLKRYYLNGHWSVDWPGRYKFSGATFNYKRSYKEPENLTSPGPTNETLIVEL
LFQGRNPGVAWEFSLPRSGAKKTPAAQPSYSWAIVRSECSVSCGGGKMNSKAGCYRDLKV
PVNASFCNPKTRPVTGLVPCKVSPCPSSWSVGNWSVCSRTCGGGTQSRPVRCTRRAHYRD
ESIPASLCPQPEPPIHQACNSQSCPPAWSTGPWAECSRTCGKGWRKRTVACKSTNPSARA
QLLHDTACTSEPKPRTHEICLLKRCHKHKKLQWLVSAWSQCSVTCQGGTQQRVLRCAEKY
ISGKYRELASKKCLHLPKPDLELERACGLIPCPKHPPFDASGSPRGSWFASPWSQCTASC
GGGVQRRTVQCLLRGQPASDCFLHEKPETSSACNTHFCPIAEKRGTFCKDLFHWCYLVPQ
HGMCGHRFYSKQCCNTCSKSNL

>Dasypus novemcinctus_ADAMTS16(ENSDNOP_1332)
RGAGAARGGWAMRARGCAALWVLLLAQVGVRAPASAAGPAAGAPASRSAPDPRPPPGPPG
WADSGEYDLVSAYEVDSRGNYVSHDISHHQRRRRALAGPGAASLHLRLRGFGQDFQLDLT
SSSSLVAPGFLVHTLGRGGTKAVQAFSPEDFCFYQGSSRSHKDSSVALSTCQGLSGMIRT
QEADYFLKPLPSHLAGNLSGSRQEGPRSHVLYKRAAERRSPPGNEILAIKRRQEPENRRS
PSHEKQHLHSGFHLRHRQKQHFCGRRKKYMPKPPSEDIFILPDEYKPSFRHKRSLLKSHR
NKELNVETLVVVDRKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLE
EEQPGLVINHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAP
ISGMCSKYRSCTVNEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSEGSIMSPTLAGRN
GVFSWSPCSRQYLHRFLSTAQAICLADQPKPGKEYKYPEKLPGELYDANTQCKWQFGEKA
KLCMLDLKKDICKALWCHRIGRKCETKFMPAAEGTVCGHDMWCRGGQCVKYGDRGPQPTH
GHWSAWSPWSPCSRTCGGGVSHRDRLCTNPKPSHGGKFCEGPTRTLKLCNNQKCPRNSVD
FRSLQCAEYNSKQFRGWHYKWKPYTHVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSE
DSRNVCIDGICERVGCDNILGSDAVEDLCGVCGGNNSDCTIHRGLYTKQHPTNQYYQMVT
IPPGARSIRIHELNSSASYISVRNSLRRYHLNGHWTVDWPGRYTFSGAAFDYKRSYNQPE
SLTSTGPTNETLIVELLLQGRNPGVAWQYSVPRAAKKPSPQPSYTWAVIRSACSVSCGGG
QMTTREGCYRDLRFPVDTSFCNPRTRPVTGVVACQLAACPPSWSVGNWSACSRTCGGGAQ
SRPVQCVQRARHRSEVVSGSLCPQPEPPGRQTCGSQSCPPAWSTGPWAECSRTCGKGWRK
RPVACKNTTPSARALLLPDAVCTADPKPKTQEACLLRRCPKPKKLLWLVSAWSECSATCG
RGIQRRFFKCAEKYISGKYRELASKKCLHLPRPSLERERACALSPCPKPTMYKAVGPPRS
SWLSSPWSQCSASCGGGVRLRSVQCLAGGRPAGGCPLLQKPMASLACNTHFCPIAEKKEA
SCKDLVSWCSLVPQHGMCAHTVYGRQCCRACSRSNL

>Xenopus tropicalis_ADAMTS16(ENSXETP_41290)
EYYIVEVYEVDRNGRFITHDISHKHRKKRSAANIDNDAVHLKLHGFGQDLHLELKVTERL
LAPGFKIQTFGEGRTKSIKTFSSQDFCFYQGSVVSHENSSVALSTCSGLSGLIRTQEAEY
FLKPMPRHVALKHNYSSSDGSQHHVLYKRALDKLLYKNNDINTVQTQQELHDSHQEMNQK
YERLEKQHYCGRRKKYIPKPPKKDMYIFPDEYRYQGRFKRSLIKLSKSKQLNVETLVVVD
KKMMQNHGHENITTYVLTILNMVSALFKDGSIGGNINIAIVGLILLEDDQPGLIINHHAD
HTLSSFCHWQSGLVGKDGSRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTV
NEDTGLGLAFTIAHESGHNFGMVHDGEGNMCKKSEGNIMSPTLAGHNGVFSWSFCSRQYL
YKFLSSAQAVCLADDPKPGKEYKYPEKLPGVLYDANIQCKWQFGEKAKLCMLDFKKDICK
ALWCHRVGRKCETKFMPAAEGTICGHDMWCRRGQCVNYGEEGPKATDGQWSEWSTWSPCS
RTCGGGVSYKERQCTNPRPSHGGKFCEGSSRVNKLCNNQSCPKNNIDFRAQQCAEYNSKP
FRGWYYNWKPYTRVEEHEYCKLYCIAEGFDFFFSLSNKVKDGTTCSEYSNNVCIDGICET
VGCDHLLGSNAVQDICGVCKGDNSTCKVYRSHYTKQHYSNQYYSIVTIPAGARSIRINEM
NISTSYISIRNNEKKYYLNGHWTVDWPGQYKFAGSVFHYKRPFNNPESLSTAGPINETLV
VEIFLQGKNPGIAWEYSMAKSVSVKKPTIKHNYTWAIIKSECSVSCGGGHMNTKEGCYKD
MRVQVNTSFCSAKNRPVTGPLPCNPQPCLPRWSVGNWTECSQTCGSGEQFRQVQCKQRKH
FKLEIVANKLCTMPPPLHRQICNTQSCPPAWSVGTWSECSRTCGKGWRKRTVVCKSTNPS
LHAQVLPDGACTTEFKPVIQEICIVKRCNKPKKLQWIISNWSECVYSISYGSNKCFVKIA
KKIYSHKYMRELKSTKIKGLVTTILDMEFYFTPIWCARHPPPPYLGENQCKTLMLEQSRC
TVSCGGGMQVRIVQCLSSGKPATRCQPHQKPKSSQACNTDFCPSEKKDNLCKDYFNWCYL
VPQHGMCNHKFYGKQCCKSCSKSNV

>Danio rerio_ADAMTS16(ENSDARP_87089)
MAVLRALPNRRNYTERVYFVLFSSLIVLGCHQRTHCASAAAHHVKHRELLETLRLPHDTE
YELVSPYEVDPEGQYISHAVSHQHRSKRSTDASTVHFRLQGLGREFQLDLRPSRGLIAAE
FTVQTLGRSGTRSLQTLDGEMMCFYQGELRMQEHSSVALSTCMGMSGLIRTRDADYFLKP
LHPHQALLENFSAPSPDHQPHILYKRPAPTNTRRTRRSSEPRPGDPAIPNRWRTSRQAEK
NTHTLINPEEMQKTTHKNSTRRRQHYCGRRKKYMPKPPEEDIYIFPDEYKLMPRGKRDVV
FKPETQPSLNVETLVVVDRKMMDNHGHENITTYVLTVLNMVSTLFKDGTIGGNINVVIVG
LILLDEDQDGLVINHHADHTLNSFCQWQSGLSGREGRRHDHAILLTGLDICSWKNEPCDT
LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSVGNIMSPT
LAGHNGLFSWSSCSRQYLNRFLSSAQATCLSDEPSAIQEYKYPEKLPGELYDADTQCKWQ
FGEKAKLCTLDFKKDICKALWCHRFGRKCETKFMPAAEGSACGPEMWCRGGQCVKQADAG
PKAVDGQWSSWSGWSSCSRSCESGVTHRERVCSSPRPAHGGRFCEGSSRSYKLCNTDDCP
ANTVDFRAAQCAEFNSKPFRGWYYKWRPYTRVDDQDVCKLYCLAEGYDFFFALSSKVRDG
TLCAQDSTDVCIDGICEKVGCDRVLGSNAVPDMCGVCKGDNSTCKIYKGQYSKQHHLSQY
YRVVTIPAGARSIRVSELNSSSSYLALRNLQRKYYLNGAWTVDWPGRHSIAGAIFDYKRP
YNRPESLSSSGPTNQTLVIEVLLQGWNPGVQWEYTLNREQKHNYSWAVVRSQCSSSCAGG
QMVSKSICYRDLRFQVNSSYCSARSRPSSGVMSCNTQPCPASWSVQDWSSCSRSCGSGQQ
VRRVVCVQKTGPDQLETVADAQCPQPAPAHTHSCNTHSCPPAWSAGAWTQCSRKCGKGVM
KRPVLCVLSNGVVLPDSSCADLLKPSVQEICFIKHCRKQRKAQWFVSTWTPCSVSCGEGL
QQRVVKCAEKDYSGKYRELSQKKCQHVSRPSVDLQRVCVQAECPAAGTHWYSSPWSQCTV
SCGGGVQIRSVQCLSLGRPASGCVLQMKPLMSQACNTAFCPQPELNDVVCKDHFSWCYLV
PQHSVCNHKFYGKQCCKSCRQSKP

>Takifugu rubripes_ADAMTS16(ENSTRUP_16801)
EYEIVSPYEVTHQGHYISHEVGHHHRRRRRSVTPGASSTINGGGETVHFRLSGLGQDFHL
ELQETSDGLIAPGFTIQVLGTNGTKSLRAYQKHDLCFYQGSLRSRVNSSVALSTCTGMSG
LIRTPDADYFLRPVSRDLAQRENFTAPSSHQPHILYRRTEPRGKGRRRPRVSATRERRHL
KRPDHGNHHSDYRHGGRQRQHFCGRRKKYMPKPPEDDTFILPDEYKFIPRNKRAVLMKTQ
HSRKLNVEMLVVVDRKMMDNHGHENITTYVLTVLNMVSSLFKDGTIGGNINIVIVGLVLL
DEEQEGLVINHHADHTLNSFCHWQSTLRGREGRHHDHAILLTGLDICSWKNEPCDTLGFA
PISGMCSRYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSEGNIMSPTLAGH
NGIFSWSACSRQYLSRFLNSAQSLCLSDEPRAAKEYRYPEKLPGELYDADTQCKWQFGEK
AKLCTLDFKKDICKALWCHRVGRKCETKFMPAAEGSACGPDMWCRRGQCVKRGDEGPRPQ
HGQWSDWSSWSACSRSCESGVTYRERHCNNPRPAYGGKFCEGSARSYKLCNTVDCPPNTT
DYRAQQCAEFNSRQFRGWHYTWRPYTKVDDQDICKLYCFAEGYDFFFALASKVKDGTLCS
QDSSNVCIDGLCERVGCDRILGSAAAPDACGICRGDNSTCKIYKGQYTKQHYTNQYYGVV
TIPAGARGIRVMELNTSSSYLAVRDTQRRYYLNGHWTVDWPGRHAIAGAIFEYKRPYNRP
ESLISSGPTNETLVIEVLLQGWNPGVRWEYTLMKADEKRKHNYTWAIVRSQCSATCAAGL
MNTKTACYKDMRVQVNTSYCNPRSRPVTGLVPCNTQPCPASWSVGEWGACSQSCGGGEHT
RLVQCIQRTSQTDADNLSDAQCVQPAPARRQACNTHSCPPVWSTGPWSQCSRKCGSGLRK
RTVLCTSTKPGVETRTLPDSLCAGLPKPGSQESCFIKRCQKLRKVQWFVSTWQECSATCG
RGYQTRFIKCAEKDTAGKYRELTDKKCHHVPKPAVELQRPCVLKECPPLPHPPPPAEWRS
SPWSQCTVTCGGGVQXCLVQGKPSSGCAFHLKPLISQACNTNFCPQPDKKDVACRDYFNW
CYLVPQHGVCNHKFYGKQCCQSCSNSNL

>Gasterosteus aculeatus_ADAMTS16(ENSGACP_8677)
EYELVSPYEVNPRGVHISYEVAHNQRRRRRRSLAQDAAGSPTNDAGSKTIHFRLSGLGQD
FHMELREASESLIAPGFTIQVLGKNGTKSLRAYHQDDLCFYQGSLRSDVNSSVALSTCAG
MSGLIRTQDADYFLRPVSHRLARRENFTAPSDHQPHILYKSDREPRAEGERKGDISRGDQ
PERHGRGHRRTRRRLDGDRTHGEKQRQHFCGRRKKYMPKPPEEDAFILPDEYEINLRNKR
AVQNQANQKLNVETLVVVDRKMMENHGHENITTYVLTVLNMVSSLFKDGTIGGNINIVIV
GLVLLDEDQDGLVINHHADHTLNSFCHWQSTLGGRQGRHHDHAILLTGLDICSWKNEPCD
TLGFAPISGMCSKYRSCTVNEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSEGNIMSP
TLAGHNGIFSWSDCSRQYLSRFLNSAQAVCLSDEPRAVKEYRYPEKLPGELYDADTQCKW
QFGEKAKLCTLDFKKDICKALWCHRVGRKCETKFMPAAEGSACGPDMWCRRGQCVKQGDE
GPTPQHGQWSEWSPLSACSRSCESGVTYRERQCNNPRPAYGGKFCEGTSRSYKLCNTEDC
PPNAADYRAQQCAEFNGKQFRGWYYSWRPYTRVDDQDVCKLYCFAEGYDFFFALASKVKD
GTLCSQDSSNVCIDGLCEKVGCDRVLGSTAVPDACGVCSGDNSTCKIYKGQFTKQYHTNQ
YYGVLTIPAGARSIRVMELNTSSSYLAVRDTQRRYYLNGHWTVDWPGRHPIAGAIFEYKR
PYNRPESLMSTGPTNETLVVEILLQGRNPGVRWEYTLKKADEKKSHVKHNYTWAIIRSQC
SATCAGGQMNTKSACYKDLRVQVNTSYCNPRSRPATGLMPCNTQPCPASWSVAEWGGCSR
SCGGGEQMRLVRCEQRSGPTGADALADARCAQPTPARRQACNTRSCPPVWTAGPWSQCSR
KCGSGLRKRTVLCTNTNPGVRTPTLTDTLCAGLSKPTSQESCFIKRCQKQRKVQWFVSTW
QECSATCGRGNQARFIKCAEKDTAGKYRELAAKKCHHVPKPSVELHRLCIQAECPIQTTP
AAHRWSMHHLTRPPQPPPQAGWQSSPWSQCTVTCGGGVQVRTAQCLVQGKPSPACGLHLK
PSMSQACNTNFCQQPEKKDLACRDYFNWCYLVPQHGVCNHKFYGKQCCQSCSNSNL

>Oryzias latipes_ADAMTS16(ENSORLP_6517)
EYEIVAPYEVSHEGVYISHRVSHHERRRRRRSLTTEAQSSNKGGSSEKVHFRLSGLGQDF
HMELWEASESLIAPGFTIQVLGKNSTKSLRAYHQDDLCFYQGSLRSRVNSSVALSTCMGM
SGLIRTQHADYFLRPVSRSLAERENFTAPVTHQPHILYKRDGVTWLKQMYHQPRALQKRS
ADSFQHLSPRPSKLSDYRPGEKQRQHFCGRKKKYMPKPPEENIYVLPDEYKFIPRNKRAV
LSKNRDIQRLNVETLVVVDRKMMDNHGHDNITTYALTVLNMMTKVDKGGKISCFFVHAIF
FLSSQDGLMINHHADHTLNSFCQWQSTLGGREGRHHDHAILLTGLDICSWKNEPCDTLVG
FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGNVCKKSEGNIMSPTLA
GHNGIFSWSPCSRQYLSRFLNTAQALCLSDEPKAAKEYRYPEKLPGELYDADTQCKWQFG
EKAKLCTLDFKKDICKALWCHRVGRKCETKFMPAAEGSACGPEMWCRRGQCVKQGDEGPG
PQHGHWSEWSSWSACSRSCESGVTSRERQCSNPRPAYGGKFCEGSAKSYKLCNAVDCPPN
STDYRAHQCAEFNSKQFRGWYYTWRPYTKVDDQDVCKLYCFAEGYDFFFALASKVKDGTL
CSKDNTNVCVDGLCERVGCDSVLGSTAVLDACGVCKGDNSTCKIYKGQYTKQHFTNQYYG
VVTIPAGARSIRVMELNTSSSYLAVRDNHRHYYLNGHWTVDWSGRHSIAGSIFEYKRPYN
RPESLLSAGPTNESLIIEILLQGWNPGVRWEYTLSNTDDRLMKNPSKHNYSWAVVQSLCT
VTCAGGRMSTNASCYKDMRVQVNTSYCNPKMKPATGVMPCNTQPCPHSWSVGEWGVCSRS
CGGGEQTRQVQCVQRTNQNNVDARADSGCAQPAPVRRQTCNTHSCPPVWSTGPWSQCSHK
CGNGLKKRTVLCVSPKADAQTRTLPDSKCAGLQKPPSQEPCFIKRCQKQRKVQWFVSTWQ
ECSAKCGQGYQARFIKCAEKDTAGKYRELPAKKCHHVPKPTVDLQRPCIVAECRSHTTPA
VHQWVTPLRTYPPQPLPHSPPEWQSSPWSHCTVTCGGGVQSRTVYCQVQGKLSSGCAPHL
KPPMSQACNTNFCPQPEKKDLLCRDYFNWCYLVPQHGVCNHKFYGKQCCQSCSNSNL

>Homo sapiens_ADAMTS17(ENST_268070)
MCDGALLPPLVLPVLLLLVWGLDPGTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPR
RRRRPRTPPAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRGR
PAELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGREHLI
RRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRLTSEHTVETLVVA
DADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHG
ERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGI
AYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKG
RNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILF
GMNATFCRNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPE
HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKG
LPSFRDQQCQAHDRLSPKKKGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGP
YETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKG
SINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYEY
TVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVND
SDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVAT
RPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDASTR
PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPY
RQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRCCQTC
RDFYANKMRQPPPNS

>Mus musculus_ADAMTS17(ENSMUSP_103102)
MCDGTLLPPLVLSLLLLVWGLDPGTAVGDAAADVEVVLPRRLRPEDVHLQLLPGAAGLRR
WRRPRASPGGHRAGQGERALLLHLPAFGRDLYLQLHRDLRFLSPGFEVEEAGVSGRSGHP
AELCFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLEQEQVFIQPLNSSGGPFIGREHLIR
RKWASTPSPATEVEGPRQRCKVVTEKKPRKDHLSRDWRERRNAIRLTNEHTVETLVVADA
DMVQYHGAEAAQRFILTVMNMVYNMFQHRSLGIKINIQVTKLVLLRQRPAKLSIGHHGER
SLESFCHWQNEEYGGARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVHKDEPCDTVGIAY
LGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRN
PSDLSWSSCSRDDLENFLKSKVSTCLLITDPRSQHALRLPHKLPGMHYSANEQCQILFGT
NATFCKNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHV
DGDWSLWSAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCQGASVEHAACEKLPCPKGVP
SFRDQQCQAHDRLSSKKRGLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYE
ADLCVYGRCQKIGCDGIIGSAAKEDRCGVCSGDGKTCRVVKGDFSHSRGTGYIEAVVIPV
GARRIRVVEDKPAHSFLALKDSSKRSINSDWKIELPGEFQIAGTTVRYVRRGLWEKFSAK
GPTTVPLHLMVLLFHDQNYGIHYEYTIPVNQSSENQSEPAKPQDALFLWTHSGWEGCSVQ
CGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVTGQWSPCSA
TCEKGVQHREVTCVYQLQNGTHVTTRPIYCSEPRPTPVQSCEGQDCLSIWEASEWSECSA
NCGKGIQKRTVTCTNSQGKCDASTRPKAEEECEDYSGCYEWKTGDWSKCSSTCGKGLQSR
VVQCMHKLTGRHGSECPTLSKPAAYRQCHQEVCNEKINVNTITSPRLAALTYKCTRDQWT
VYCRVIREKNLCQDMRWYQRCCQTCRDFYADKMRQPPSPPSS

>Gallus gallus_ADAMTS17(ENSGALP_11434)
MFDGCLLPLVFPCLLLWGLDAGTAGGAELEVVIPERVALERIHLLPPAGRGDRGGARRRR
ELLRPREAAGEALLLRLPAAGTELYVHLRRDLRFLSRGFVVEHRRGEERRPPAERLCFYT
GRVLNRSDSFASLSTCAGLKGGYVGYIQIGSEHMLIQPVNTSETSFSGKEHFIRRRRSTK
SSHSLKSQIPDEHCKVVAEKKRQKKMKSTSDWRERRNAIRLTNEYTVETLVVADADMVQY
HGAEAAQRFILTVMNMVYNMFQHQSLGIKVSIRVTKLVLLRSRPAKLSIGHHGERSLESF
CHWQNEEYGGAKYLGNNQVPGARDDTPPVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVC
SAKRKCVLAEDNGLNLAFTIAHELGHNMGMSHDDDHPPCAGRSHIMSGEWVKGRNPSDLS
WSSCSRDDLENFLKSKVSTCLLVTDPRSQYAVRLPHKLPGMHYSADEQCQILFGTNATFC
KNMEHLMCAGLWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWS
VWSQWSMCSRTCGTGVRFRQRKCDNPPPGPGGKNCRGASVEHTVCENLPCPKGVPSFRDQ
QCQAHDRYTNKKKSLLTAVVVDDKPCELFCSPLGKDSPVLVTDRVLDGTPCGPYETDLCV
HGKCQKIGCDGIIGSAAKEDRCGICSGDGKTCKVVKGDFNHTKGMGFKDSSKRSINSDWK
IELPGEFQIAGTTVRYVRRGLWEKISAKGPTKIPLHLMLNQVLLFHDQNYGIHYEYTIPV
NYTANRSEPEKQQDSLYIWTHSGWEGCSVQCGGGERKTIVSCTRIINKTMTVVNDSNCQR
VNRPEPQVRKCNTHPCQSRWVTGLWSPCSATCEKGIQHREVTCVYQLQNGTYVNTRDLYC
LGNKPATVQSCEGRDCLSIWEASEWSKCSADCGKGIQKRTVTCTNSQGKCDAATRPRDEE
ECEDHTGCYEWKTGDWSKCSSTCGKGLQSRVVQCMHKVTGRHGSECPVLSKPAAYRQCHQ
EVCNEKINVNTITSPRLAALTYKCTGDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYA
NKMQQKS

>Xenopus tropicalis_ADAMTS17(ENSXETP_40681)
EDWRGRRNAIRLNEEHTVETLVVADSDMVQYHGAEAAQRFILTVMNMVYNLFQHQSLGIK
VNIRVTKLVLLHSRPARLSIGHHGERSLESFCHWQNEEHGSKYLGNNQVPGAKDDIPVDV
AVFMTRTDFCVHKDEPCDTVGIAYLGGACSAKRKCVLAEDNGLNLAFTVAHELGHNMGMS
HDDDHPSCAGRSHIMSGEWVKGRSPSDLSWSTCSRDDLENFLKSKVSSCLLVTDPRSHYA
VRLPHKLPGMHYSASEQCQILFGSNATFCKNMEHLMCAGLWCLVEGDSSCKTKLDPPLDG
TECGADKWCRAGECVGKTPIPQHVDGDWSAWSSWSMCSRTCGTGARFRQRKCDNPPPGPG
GRSCRGASVEHMVCENLPCPKGVSSFRDHQCQSHDRSSNKKKSPLTAVIIDDRPCELFCT
PVGRDTPVLMADRVLDGTPCGPYEIDLCVHGRCQKIGCDGIIGSSAKEDRCGICNGDGKT
CKVVKGDFNHTKGMGYIEAAVIPAGARRIRVVEDKPAHSFLALKDSIKKSINSDWKIELP
GEFQIAGTTIRYVRRGLWEKISAKGPTKTPLHLMVLLFHDQNYGIHYEYTIPVNQSSEQK
PEPEKQPDPMYMWTHSGWEGCSVQCGGGERRTVVSCTKIVNKTMVIVNDSLCLHTSRPVP
QVRKCNVHPCQSRWVAGTWNQCSSTCDRGFQLREVTCVFQLQNGTFVNTQDFYCLGPKPA
TRQICEGQDCLSIWEASEWSKCSSDCGRGTKKRRISCSNSKGKCDSATRPRAEEECEDYT
GCYEWKTGDWSKCSSTCGKGLQSRVVQCMHKVTGRHGNECAIISKPVAYRQCHQEACNDK
VNANTITSPRLAALTYKCTGDQWTVYCRVIREKNLCQDMRWYQRCCQTCRDFYANKVQPQ
S

>Danio rerio_ADAMTS17(ENSDARP_100254)
MFFISVCVFLLSFLFSMGMSHDDDHASCTGHSHIMSGEWVKGRNPSDLSWSTCSRDDLEK
FLRSKASGCLLHTDPRNRYLVRLPAKLPGMHYSADEQCQILFGTNATFCTDMEHLMCAGL
WCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPQHVDGDWSPWSTWSMCSRT
CGTGARFRQRKCDNPPPGPGGKYCQKASVEHKVCEGPPCTKGLPTFRDQQCQSHERQASK
KSQMWTAVIDDEKPCALYCTPVGSDSPVLVAERVLDGTPCGPYESDLCVNGKCQKIGCDG
IIGSSAKEDRCGVCNGDGKSCRIVKGDFNHSKGMGYIEAAVIPVGARRIKVVEDKPSHSF
LALKDSSKRSINNDWKIELPGEFELAGTTVRYVRRGLWEKMSAKGPTKTPLHLMVLLFHD
QTYGIHYEYTVALNHSQENSSDLVKEPEHMYLWTHSSWEDCSVHCGGGERRTVVSCMRII
NKTMTPVNDSSCQVENKPSPQIRQCNIHPCQYRWVTGDWTQCSLTCGKGLQQREVGCIYQ
LQNGTYIPTRDLYCLSSKPASVQHCEGRHCLTVWEASEWSQCSSECGHGSRRRTVTCTNP
HGLCDPVSRPAEVEACEDHSKCYEWKTGEWSKCSSSCGRGLQSRVVQCMHRVSGRHGSDC
PAVLKPATYRQCHQSTCNARGNINTITSPRLAALTYKCVGDQWAVYCKVIREKNLCQDMR
WYQRCCQTCRDFYTNKMPPKS

>Gasterosteus aculeatus_ADAMTS17(ENSGACP_16578)
DTDEVVPRLLSGQEAHLSSGRSASPPWRRGQRSTDAPRGRHSDPAQIIVSLTAFGMRLYL
NLTWDSTFISGDFEVEERRGDQSAASSRLSKKQLCFYSGSVINHTGSVASLSTCGGLTGL
IQIREESLFIQPVGEYGPYQSFSGMKHWLLRHQRCATTSSSPDGNCWIVRGKEKMPNMGE
KGRRKRNVLHLQEAYTVETVVVADSNMVQYHGAEAAQRFLLTVMNMVYNMFQHKSLGVKI
NIRVTKLVILHSRPEQLKVGHHGERYLESFCHWQHQEFGRLRYLGTDHFPGGWEDIPPVD
TAVLVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCALAEDNGLNLAFTIAHELGHNMGM
SHDDDHATCTSHSHIMSGEWIKGRNPSDLSWSSCSRTDLENFLRSKASACLQQTDSRSRY
QIRLPPKLPGMHYSVDQQCQILFGTNASFCSNMEHLMCAGLWCLVEGDAACKTKLDPPLD
GTECGPDKWCRSGKCVNKTPIPQHVDGDWSPWSQWSVCSRTCGTGVHFRQRKCDNPPPGP
GGRHCQKANVEHKACERPPCPNGATGFRDQQCLSYDQHGSKNKGLLTAIINDEKPCALFC
SPVGRDVPVLMADRVMDGTPCGPYEADLCVNGRCQKIGCDGIVGPTAKEDHCGVCNGDGR
SCKIASGKFTHTKGMALRDSIKRSINSDWKIELPGEFELAGTTVHYVRRGLWEKMSAKGP
TKTPLHLMVLLFHDQSYGIHYEYTVSLNTTQDSDTHLYIWTHSNWQDCTVKCGGGERRTV
VSCVRIANKTMEAVNNSYCHPENRPLPKVRLCNSQPCQYRWLTGEWGSCSITCGKGLQHR
EVVCVYHLQNGSRIHTRDLYCQGGKPPVLQACEGHLCLTVWEASEWSKCSSDCGQGVHKR
TVSCTNPEGVCDPFSRPKEEEPCEDLSKCYEWKTGDWSKCSASCGKGLQSRVVQCMHKLT
GRHGNDCSVMLRPPTYRPCHQGTCIDQINVNRVASLPSCSDLLMHWDQWCCRVIRETNLC
QDMRWFQRCCETCGDIYAKKMLKEKQLS

>Homo sapiens_ADAMTS18(ENST_282849)
MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD
YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS
HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP
LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE
TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV
ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH
ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI
CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE
CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS
KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC
ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ
ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET
LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC
LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS
EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG
GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ
HGVCNHKFYGKQCCKSCTRKI

>Mus musculus_ADAMTS18(ENSMUSP_90801)
MECALLCLCALRAAGPGPPWGPAGLGRLAKALQLCCFCCASVAVALASDSGSSGGSGLND
DYVFVVPVEVDSGGSYISHDILHHRKRRSAHGASNSLHYRVSAFGQDLHLELKPSAILSS
HFRVQVLGKDGASETREPEVPQCLYQGFIRNDSSSSVAVSTCAGLSGLIRTRDNEFLISP
LPQLLAQEHNYSSPAGHHPHVLYKRTAEKRVRWYQDYPGSQRTYPGHSPSHTPPASQSQE
PEYSHRRWQKRHFCGRRKKYAPKPPAEDAYLRFDEYGGTGRPRRSAGKSQNGLNVETLVV
ADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGTIGSDINIVVVSLILLEEEPEGLLINHH
ADQSLNSFCQWQSALVGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
TINEDTGLGLAFTIAHESGHNFGMVHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
YLKKFLSTPQAGCLVDEPKQTGQYKYPDKLPGQIYDADMQCKWQFGAKAKLCSLGVMKDI
CKSLWCHRVGHRCETKFMPAAEGTACGLSMWCRQGQCVKLGELGPRPIHGQWSAWSKWSE
CSRTCGGGVKFQERHCSNPKPQYGGKYCPGSSRIYKLCNINPCPENSLDFRAQQCAEYNN
KPFRGWLYRWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPHRNDVCIDGIC
ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLSQHKANEYYPVVTIPAGARSIEIQ
ELQLSSSYLAVRSLSQKYYLTGGWSIDWPGDFTFAGTTFEYQRSFNRPERLYAPGPTNET
LVFEILTQGKNPGIAWKYALPKVMNVTQPATKRYHHTWRTVQSDCSVTCGGGYISIKAIC
LRDQHTQVNSSFCSVRTKPATEPKICNAFSCPAYWLPGEWSACSKSCAGGQQSRKIRCVQ
KKPFQKEEAVLHSLCPVSTPTQVQVCNSHACPPEWSPSPWSQCSKTCGRGVRRREVLCKS
PAAETLPESLCSSSPRPEAQEGCVLGRCPKNNRLQWIASAWSECSATCGLGVRKRELKCV
EKTLQGKLITFPERRCRNIKKPSLELEEACNQRTCPVYSMAVASWYSSPWQQCTVTCGGG
VQTRSVHCMQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKKDDPSCVDFFSWCHLVPQHG
VCNHKFYGKQCCRSCTRKS

>Gallus gallus_ADAMTS18(ENSGALP_8559)
MDCLLLVVWTLPAAILSGSSMQFPTFLWLGNAVKTLQLCCLCCMSHAASLTSDSISSSEL
NHDYVFVTPVKVDSSGLYISHNVLHSTRKKRSTHSSRSSLHYKFSAFGQELHLELKPSTI
LSNSFIVQVLGKDGVSNSQEHEIEQCFYQGFIRNDSTSSVAISTCVGLSGLIRTRKIEFL
ISPLPQQLAQEHNYTSPAGHHPHVLYKRTAEEKVHRYTVESNPKSFSLGHHRTHIYHKYH
AQANGYHHGRFQKQHFCGRRKKYAPKPPTEETYIRSDEYGTSARFRRSSAKIQKNGSLNV
ETLVVADKKMVEKHGKENVTTYILTVMNMVSSLFKDGTIGSDINIIVVSLLLLEQEPSGL
LINHHADQSLNSFCQWQSALVGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCS
KYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWS
VCSRQYLNKFLSTAQAACLIDEPKQTGQYKYPDKLPGQMYDADTQCKWQFGMRAKVCNLS
FVKDICKSLWCHKVGHRCETKFMPAAEGTACGINMWCRRGQCVKYGDHGPKPVNGHWSAW
SEWSQCTRTCGGGVTYQERHCNNPKPQYGGKFCQGSSRIYELCNHQPCPASSLDFRAQQC
AEYNSKPFRGWYYKWKPYTKVEEEDRCKLYCTAEDFDFFFAMSSKVKDGTLCSPNKYDVC
IDGICEQVGCDHGLGSKAVLDACGVCKGDNSTCKFFKGQYLIQHKANDYYAVVTIPAGAR
SIHLHEMQISNSYLAVRNLSKKYYLTGDWTIDWPGKFPFAGTVFDYQRSFNHPESLYAAG
PTNETLVFEILLQGRNPGIAWEYTFSKMNENKTSVKKHSHSWVTVQSECSATCGGGHITA
KAICLEDHRTRVNSSFCGPRMKPLTETKLCNTNPCPAHWSAGEWSACSKSCGGGQQSRLI
QCVQKKAFQREEVVAHSLCPVSTPTQVQICNSQDCPPEWSPGLWSQCSKTCGRGVKKRDV
YCTSTSSPKLKILPESMCSQDHKPESQQTCVLGRCPKNDRLQWVIASWSECSASCGPAVR
KRELKCGEKSIHGKLITFPQRRCRNIKKPNIDLEEACNNGPCPSQTLYNMVSGWYSSPWQ
QCTVTCGGGVQTRSVQCLRQGRPASGCLPHQKPAILRACNTNFCPAPSKRDDPSCVDFFS
WCHLVPQHGVCNHKFYGKQCCKSCTKKN

>Xenopus tropicalis_ADAMTS18(ENSXETP_27786)
IGSLDKTFQLYCLCCVSFAASLNSDSGVGGLNHDYFFVTPIEVDISGAYVSHDILHISRK
RRSARSSKSSLHYRFSAFGQELHLELQQSSVLSDEFYVQVLGKNGSITDVEQEAASCFYQ
GFIRDYENSTVAVSTCDGMSGFLRTHTSEFFISPLPQHLAEKHNYTSPDGHHPHVLYKRS
AEVKVAPNKAYSNPANEKHPARSEQTLSGSQTLQKHFCGRRNKHSQKLLTKNAYVRADEY
ENLSRAKRSATKSQHSGGLVVETLVVADKKMVDKHGKDSVTTYILTVMNMVSSLFKDGTI
GTDISIVVVSLLLLEDEQAGFTINHHADQSLNNFCQWQSALTGKHGKRHDHAILLTGLDI
CSWKNEPCDTLGFAPINGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCG
KAEGNIMSPTLTGNNGLFSWSACSRQYLKKFLSTAQSACLIDEPKQSGHFKYPDKLPGQI
YDADTQCKWQFGPRAKQCSLSFVKDICKSLWCHKAGHRCETKFMPAAEGTVCGLNMWCRR
GQCVRFGDHGPKPVNGAWSDWSDWSECSRKCGGGVMYQERHCNKPKPQYGGKFCQGSSRI
YQLCNIQSCPPNTVDFRAQQCAEYNSKPFRGWYYKWKPYTRVEEENICKLYCTAEDFDFF
FAMSNKVKDGTPCSTTGYDVCIDGSCELCGCFKCALAKFQEEICSKLTLDPQQAFHNLAL
LTVKNLSRYYSVVTVPAGARSIHVREHEVSTSYLAVRNLKKKYYLTADWTIDWPGKFSFA
GTIFNYQRSFQQPESIYAAGPTNETLVFEILFQGKNQGLTWEYTLPNSVKENTTTIITKN
FSWFSVYSGCSVTCGGGHMMAKLVCIQDHYIQVDSSLCALQAKPHSVPKVCNDQPCPAYW
SVSEWSSCSVSCGGGQQTRQIQCVQKTLMQTEMLVGHSQCPVSTPSQVQACNVQDCPAEW
SSGPWSQCSRSCGKGMKKREVFCRSMNSGKYKILPENLCPMQAKPESTESCVLARCQKHD
KLQWAISAWTECSATCGPGVKKRELKCVEKDSHGKLIPFPLKRCRSVKKVNIALEQPCNS
APCPVHTPYSTFNGWHASPWQQCSVTCGGGVQSRSVQCVHQGRPAAGCLPYQKPPTSQAC
NIHFCPTSETQESASCIDYYSWCSLVPQHGVCNHKFYGKQCCKSCARKK

>Danio rerio_ADAMTS18(ENSDARP_23956)
MHTNMDCLFLLLWSLQVPLVTCTSFRSLASVSFGNFLKAVQFCCLHSVASVSFTGDTGGL
YQDYDFATPVEVDSYGGYISHDVSRHGRSRRSLSEAGSLVHYHVSAFGKELHLDLQPSHV
LAEGFTVQTLGAEGINTATLDPSIHNCFYQGSIRNHSDSSVALSTCTGLSGLIRYSSEEL
FITPLPQHLALQHNYSAPSGHHPHVIYKRSAERRVHADKTDRTSRFKSSNPYEDHHHHHH
HHRHHDYQHGKLQRQHFCGRRKQYTPKPPTEDHFVMPDEFEQQIRVKRSEITSSKEGGLN
VETLVVADRKMLEKHGRDNVTTYVLTVMNMVSSLFKDGTIGNDINIVVVSLLLLEKDPLG
LSINHHADQSLNSFCQWQSGLVGKNGKRHDHAILLTGLDICSWKNEPCDTLGFAPISGMC
SKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKTEGNIMSPTLAGNNGVFSW
SACSRQYLNRFLGTAQASCLVDEPKQIGQYKYPEQLPGQLYDADIQCKWQFGSKAKLCGL
DFVKDICKSLWCHRTGHRCETKFMPAAEGTICGADMWCRKGQCVKFGDHGPKAVHGQWSG
WSEWSDCSRTCGGGVMYRERSCNSPSPQHNGKFCQGPGRLHQLCNTKPCQPDGVDFRAQQ
CAEYNSKPFRGWYYKWKPYTKVEEEDICKLYCIAEDFDFFFAMSSKVKDGTSCSDYKGGV
CIDGICEPVGCDQVLGSKAALDACGVCKGDNSTCKFYSGQYTLQHRANEYYPVVMVPAGA
RSIQVQEMEISNSYLAVRSLKRGTYYLTADWTVDWPGRFQFAGTTFNYQRSFNRPETLFA
TGPTNETLLFEILLQGKNPGITWEYTLPHPEKKHNYTWSVVRSDCSAPCAGGRVSTKAIC
LQDQQTQVNSSLCNPQTRPVVGSHLCNTQPCPAYWTTGKWGVCSRTCGGGQQTRNIRCLR
KVTYQREEVAAQSLCPVMAPAQLQPCNTQSCPPEWSTSSWTQCSKTCGRGLKKRSVFCRS
TDPGARAVVVPDSMCKLHLKPKAQESCVLSRCPKNERLQWITSAWGECSASCGAGVRRRE
LHCGEKDSQGGYTEFPARRCRNLQKPEADLEQSCNNGPCPEPLAPQLLQPGGPSVTLGWY
SSPWLQCTVSCGGGVQTRSVQCLRQGRPSVGCFPHQRPISSRACNTHFCPAPIPVPVPPP
SPTLKEDQPCIDFFSWCHLVPQHGVCNHKFYGQQCCKSCSAKRQ

>Takifugu rubripes_ADAMTS18(ENSTRUP_26165)
YCSHTPHVASASYSSSGSHGLNHDYVFVTPVEVNSDGGFLSHDVTGRSHRARRSLSPSVH
YRLSAFGQDMQLDLHPSSVVGPGFTVQSLGSEGITTVTDDAGFHNCLYQGFVRNLSSSSA
ALSTCSGLAGFIRMSQEEYLIAPLPQHLAEEHNYRAPDGHHPHVIYKRSAEHVVHRGSSG
TSSSRPANPYQQQHHHQQLHQQHHHHHDDQQEKLERKHFCGRRKQYAPKPPTDDRFIMPD
EFATPATDESGRAKRSPINSNRVGGLNVETLVVADRKMLEKHGRDNVTTYVLTVMNMVSS
LFKDGTIGSDINIVVVSLLLLEEDPLGLTISHHADQSLNSFCQWQSGLLGKGGKRHDHAV
LLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHD
GEGNPCRKTEGNIMSPTLAGNNGVFFWSTCSRQYLSRFLGTTQASCLVDEPKQIGQYKYP
EKLPGQLYDADTQCKWQFGSKAKLCSLDFVKDICKSLWCHRTGHRCETKFMPAAEGTTCG
PDMWCRRGQCVKFGEHGPKAVHGQWSAWSQWSDCSRTCGGGVMYRERSCTSPRPQNNGKF
CPGSSRFNQLCNTRPCPPNTVDFRAQQCAEYNSKLFRGWYYKWKPYTKVDDEDICKLYCI
AEDFDFFFAMSSKVKDGTPCSKTETNVCIEGVCEEVGCDQILGSQASLDACGICKGDNST
CKFFKGQYTLQHRANEYYTMVVIPAGARSIHVQEMAVSTSYLAVRSIKKKYYLTGDWTVD
WPGKFHIGGTMFDYQRSFNKPESLYAAGPTNETLVFEILLQGKNPGVVWEYTLPRTEKKP
DYSWGVVRSDCSAPCAGGRISTKAICLQDQKVQVNSTMCNPYTKPILGYHLCNTQPCPAY
WAPGDWGLCSRSCGGGQQTRPLRCLRKVTYQREEVVAHSLCPIISPAQVQPCQTQTCPPE
WSTGSWSQCSKTCGRGLRKRSVFCSSTDPGVTAVVVPDSMCRQHHKPKAQETCVLRRCPK
NERLQWFPTPWGECSRSCGSGFQRRELHCGERDPNGGNVEFPIRRCRNIARPLVDLQRSC
NRSPCPEPSHAVPGRSPSSAVVLGWYSSPWQQCSVSCGGGVQTRSIQCLRQGRPAAGCLP
HQRPVTSRACNTQFCPAAPFAAEPQCTDHFSWCHLVPQHGVCNHKFYGQQCCRSCSRKR

>Tetraodon nigroviridis_ADAMTS18(ENSTNIP_14845)
VETLVVADRKMLEKHGRDNVTTYVLTVMNMVSSLFKDGTIGTDINIVVVGLLLLEEDPLG
LTISHHADQSLNSFCQWQSGLLGKGGKRHDHAVLLTGLDICSWKNEPCDTLGFAPISGMC
SKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKTEGNIMSPTLAGNNGVFFW
STCSRQYLSRFLGTNQASCLVDEPKQIGQYKYPEKLPGQLYDADTQCKWQFGSKAKLCSL
DFVKDICKSLWCHRAGHRCETKFMPAAEGTTCGPDMWCRRGQCVKFGEHGPKAVHGQWSA
WSQWSDCSRTCGGGVMYRERSCTSPRPQNNGKFCPGSSRFNQLCNTRPCPPHAVDFRAQQ
CAEHNSKPFRGWYYKWKPYTKVDDEDICKLYCIAEDFDFFFAMSSKVKDGTPCSKSEKNV
CIEGVCEAVGCDQVLGSQASLDACGICKGDNSTCKFFKGQYTLQHRANEYYTMVIIPAGA
RSVHVQEMEVSTSYLAVRSMKKKYYLTGDWTVDWPGKFHFGGTTFDYQRSFNKPESLYAA
GPTNETLVFEIKCCGYVLKDDISRMWWEKLLMEHFSAVVPQFKHWAPADWGPCSRSCGAG
QQTRLLRCLRKVTYQREEVVAHSLCPIISPAQVQPCQTQTCPPEWSTGSWSQCSKTCGRG
LRKRSVFCSSTDPGVTAVVVPDSMCRQHHKPKAHETCVLRRCP

>Gasterosteus aculeatus_ADAMTS18(ENSGACP_18936)
SSSDRHGLNHDYVFVTPVEVDSEGGYLTHDVTRRSSRSRRSLSSSLHYRLSAFGQDMHLD
LVPSPVVGPGFTVQTVGLDGIATVMDDVGFHDCLYQGFIRNASASSAAISTCSGLSGLIR
VSQEEYLIAPLPQHLAAQHSYSAPDGHHPHVVYKRSAEHIVHRRSGRSSSTGSSTPDNPE
RGKLHFCGRRKQYAPKPPAEDSFIMLDDFVVPEAEGAGRLKRSPINSNRVGGLNVETLVV
ADRKMLEEHGRDNVTTYVLTVMNMVSSLFKDGTIGTDINIVVVSLLLLEQDPLGLTINHH
ADQSLNSFCQWQSGLVGKGGKRHDHAVLLTGLDICSWKNEPCDTLGFAPISGMCSKYRSC
TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKTEGNIMSPTLAGNNGVFSWSTCSRQ
YLSRFLGTAQASCLVDEPKQIGQYKYPEQLPGQLYNADTQCKWQFGSKAKLCSLDFVKDI
CKSLWCHRTGHRCETKYMPAAEGTGCGPNMWCRRGQCVKYGEHGPRAVHGQWTAWSQWSD
CSRTCGGGVMYRERSCTSPRPQNNGKFCSGSSRLNQLCNSRPCPPKSVGFRAQQCAEYNS
KPFRGWYYKWKPYTKVDDEDICKLYCIAEDYDFFFAMSGKVKDGTSCSEHKGDICIDGVC
EAVGCDQILGSKASLDACGACKGDNSTCKFFKGQYTLQHRANEYYSMVSVPAGARSIRVY
EMEASPSYLAARSLKRKYYLTGDWTVDWPGKFHFGGTVFDYQRSFNKPESLYAAGPTNET
LVFEILLQGKNLGVVWEYTLPRAERKPDYSWGVVRSDCSAPCAGGRISTKAICLEDQKVQ
VNSTMCIPHTRPALGSHLCNTQPCPASFWASGDWGLCSRSCGGGQQTRTLRCLRKVTYQR
EEVAAHSLCPVISPAQIQPCHTQACPPEWSTGSWSQCSKTCGRGLRKRSAFCRSTDPGAK
AVVVPDSMCRQHHRPKTQETCVLRRCPKNERLQWVTAAWGECSRSCGSGIQKRELRCGER
DSQGGYVEFPVRRCRNIAKPLVDLQQGCNRGPCPELPRAVPGRTSSGAVTLGWYPSPWQQ
CSVSCGGGVQARSIQCLRQGRPAGGCLPHQRPVTSRACNTHFCPAAPPADEPCVDHFSWC
HLVPQHGVCNHKFYGQQCCKSCSSGR

>Oryzias latipes_ADAMTS18(ENSORLP_18985)
MDYLFLLIWTLPVPLVGCTSVRLLSTLLSWNIIKTLHIYCTHSVLASSSFSSSHGLNHDY
IIVTPVEVDSDGAYLTHDVGRRSHRSRRSLSSSLHYSFSAFGQDLHLDLRPSSVVGPGFT
VQTLGSGGISTVTGDAGFRNCLYQGFIRNLSESSAAISTCSGLSGLIRVSQEDYLLAPLP
QHLAEQHNYSAPAGHHPHVVYRRSADHIVHRKTRSSSGSSSSRSDDSYLHHLQRQQSFGS
QPGKLQRRHFCGRRKQYTPKPPAENLFIMPDEYATPEAGEPARAKRSPINSNRVGGLNVE
TLVVADRKMLEKHGRENVTTYVLTVMNMVSSLFKDGTIGTDINIVVVSLLLLEQDPLGLT
VNHHADQSLNSFCQWQSGLVGKGGKRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSK
YRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKTEGNIMSPTLAGNNGVFSWST
CSRQYLSRFLGTAQASCLGDEPKQIGQYKYPEQLPGQLYDADTQCKWQFGSKTKLCSLDF
VKDICKSLWCHRAGHRCETKFMPAAEGTTCGPDMWCRKGQCVKYGDHGPRAIHGQWSAWS
QWSDCSRTCGGGVMYRERSCNSPRPQNNGKFCPGSGRLNQLCNPQSCPVNAVDFRAQQCS
EYNSKPFRGWYYKWKPYTKVDDEDICKLYCIAEDYDFFFAMSSKVKDGTPCYDHKGDVCV
DGVCEAVGCDRILGSKAFVDACGVCKGDNSTCKFFKGQYTLQHRANEYYSMVTVPAGARS
IRIQEMEVSTSYLAVRSLKRRYYLTGDWTVDWPGKFLFGGTVFDYQRSFNKPESLYAAGP
TNETLVFEILLQGQNPGVMWEYSLSRTERKPEYSWGVVRSDCSAPCAGGRISTKAICLQD
QKTQVNSSMCNPHSRPTLGSHLCNTQPCPAYWAAADWGPCSRSCGGGQQTRTLRCLRKVT
YQREEVVALSLCPAISPAQIQPCNTQACPPEWSTGSWSQCSKSCGRGLRKRSVFCRSTDP
GIKAVVVPDSMCKQHHRPKAQETCVLRRCPRNEKLQWMLTPWEECSRSCGSGNQRRELRC
GERDAHGGFVEFPVRRCRNLAKPLVDLQQLCNRGPCQELVPGRASSTVVLGWYSSPWQQC
SVSCGGGVQTRSIQCLRQGRPAAGCLPHQKPVTSRACNTHFCPAAQRPAEELCVDQFSWC
HLVPQHGVCNHKFYGQQCCKSCSSKK

>Homo sapiens_ADAMTS19(ENST_274487)
MRLTHICCCCLLYQLGFLSNGIVSELQFAPDREEWEVVFPALWRREPVDPAGGSGGSADP
GWVRGVGGGGSARAQAAGSSREVRSVAPVPLEEPVEGRSESRLRPPPPSEGEEDEELESQ
ELPRGSSGAAALSPGAPASWQPPPPPQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLL
RRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCG
GGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDK
GRPRSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNL
FQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMST
NWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTI
AHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNC
LLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGEKE
CRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCSAGISSRERKC
PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQWQAVLDEE
KPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCG
VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN
SDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHYEYTIP
SDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY
LTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC
IGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAE
DCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHL
QPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRDFYA
QKLQQKS

>Mus musculus_ADAMTS19(ENSMUSP_50535)
MGPEMRLTRICCCCCLLYQLGFLSHGTTSGLQLTPDLEEWEVVFPALWRRESLNATGLSG
GSSDPGSGRSSGGGGRGQASGSSREVRSVARAPQEEATRGQSEPWFGSPLEPGAEDEEEL
ESQELPRGSSGDTALSSGTPASWQPPLPPQRPSSPPPAQQEEPSAEEVLLRIPALSRDLY
LLLRRDGRFLAQRFAVEQWPKPGPDPTRATADPGSSLLPDASCFYTGTVLRHPGSLASFS
TCGGGLMGFIQLNEDFLFIEPFNDTMAIIGHPHRLYRQKRSTEEKVTENSAVHRHHCGVI
SDKGRPRSKKIADNRREKRYSYKLSQEYNIETVVVADPAMVSYHGADAARRFILTILNMV
FNLFQHKSLGVQVNLRVLKLILLHETPADLYIGHHGEKMLESFCKWQHEEFGRRNDVHLE
MSTSWGEDIAAVDAAILITRKDFCVHKDEPCDTVGIAYLNGMCSEKRKCIIAEDNGLNLA
FTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKA
SSCLLHTDPQSLSSVLVPSKLPGMAYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEG
EAECRTKLDPPMDGTDCDPGKWCKAGECTRRTPAPEHLAGEWSPWSSCSRSCSSGVSSRE
RKCPGLGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSYPKHALQWQAVF
DEEKPCALFCSPVGKEQPVLLSEKVMDGTSCGYQGLDICANGRCQKAGCDGLLGSLARED
HCGVCNGNGKSCKVIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSFLALRDASKQ
SINSDWKIEHSGAFSLAGTTVHYLRRGLWEKISAKGPTTTPLHLLVLLFQDQNYGLHYEY
TVPSDPLPDNQSSKEPGPLFMWTHAGWGDCNATCGGGERKTMVSCTKIMSKNISLVDNKK
CKDLTKPEPQIRKCNEQPCQTRWMMTEWTTCSRTCGKGVQSRQVACTQQLENGTLIRAWE
RDCLGPKPATVQRCEGQDCMTVWEAGVWSECSVKCGKGVRHRTVRCTNPRKKCVLSTRPR
EAEDCEDYSKCYVWRVGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRP
CHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDMRWYQRCCETCRD
FYAQKLQQKS

>Anolis carolinensis_ADAMTS19(ENSACAP_1461)
GLQLLGDSEEWEIVYPALWSRDQQEPIGGSGAGGSCSPDGNCGNNSSNISATSASTQVVG
SSREVRSVSFSSSRQFQLVGETSEDEVSEDEYESQEFYHWSQGSNATSQLPPPPPLSSSP
EDEVLLRIPAFAQELYLLLKRDSRFLAPGFAVEERLKSERRSLPYSAKTHTERSCYYSGS
VLHHPGSFASFSTCGGLMGFLQMNDDFIFIEPLNHTLAVTGHAHRVYRRKRSIHERATEN
PTSHSQYCGVLTEKRRAKGQKGTESGRGKRYSYKLPQEYNVETVVVADPAMVSYHGADAA
RRFILTILNMVFNLFQHKSLGVQVSLRVTKLVLLHETPVRKYCICLFHVKILEAGLKGHH
PEFGIQYKIHSKISVIWVDDVTAKQSCVPAKKKDFCVHKDEPCDTVGIAYLNGMCSEKRK
CIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCS
REDLERFLRSKASNCLRQTNPQSINSVIIPSKVPGMTYTSDEQCQILFGPTASFCQEMQH
VICTGLWCKVEGEKECKTKLDPPMDGTDCDTGKWCKAGECTSKMSFPGHMEAEWSTWSTC
SRTCNTGISSRQRRCSGSVHDGGECHGTRIQYKICENPSCPPGVPAFRDWQCQVFSVRPS
YQKHVQQWQAVIDEEKPCALFCSPNGKDQPILVTEKVMDGTSCGHQELDICANGRCQKFG
CDGILGSLTWEDHCGVCNGDGKSCRVVKGDFNHTRGAGYVEALVIPAGARRIKVVEEKPA
HSYLALRDTGKQSINSDWKIEHSGTFNIAGTTVQYVRRGLWEKISAKGPTTSPLHLLVLL
FQDQNYGLHYEYTIPLDPIPENQSSKVSEPLFMWTHSGWEDCDAVCGGGERKTTVSCTKI
MNKNISFVDNRKCKYLTKPEPQVRKCNEQPCQTRWMMTEWTPCSRTCGKGTQNRQVACTQ
QLRNGTMIRARERDCVNPKPNAAQRCEGQDCMTVWEAGVWSECSVKCGKGVRHRTVRCTN
PRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE
CFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDM
RWYQRCCETCRDFYAQKMQQRS

>Ciona intestinalis_(ENSCINP_34072)
LKFLLWLCCIVQVRSGGTGVVGGWLTLSRVDELRSRFVEFEIIEPTVVTATGQYISHDVT
NARRHTEERNTTSQEHLHFNLTVFGESLKLRVRSKSHLISPRAKSVLFTSGGGRVERKLD
PGCVFTGEIPQLPHSNVAISNCDGLAGLIRTPDDEIFIEPIEDRHVTGPQKHVIYRRSAT
KNSANHGQRMEALKPTKRDDTRDSMQGSLEVILEQTKRERSKRHAKRNDYNMEILLTVGH
EIVRVHGRHHVENYLVTLMNIVDEIYHDDSLGEHINIILTRIYQLDAVRTNNLIVENEPK
TSLNNVCHWAKDIQVTDPAPNGRTYDAAIFLTRIRFGTAGMGIKEGWGYAHVDGLCQPLR
SCSLTYEDGFSSAFVVAHETGHILGMKHDGDFNRCGDETTMGSIMAPLVQAAFHRYHWSR
CSQEELRSSLGSYTCLSDDPHLQDWGPTPLYPGVAYSVDDQCRFDFGRGYKRCTSLQNID
VCKTLWCSNDENPDICKTKKGPAVDGTECGDNMWCFKGHCVWRDQRQTAVDGNWGSWNTY
GQCSRSCGTGVWYRTRMCNNPMPSHGGVDCIGQNIDFDLCSKRPCPNGRDFREEQCQYQK
EVLYKGQKHKWFPYEPRDASLKCELYCVSKRTHDIVSMGDIVGDGTRCSYEDPHGICVRG
ECVDIGCDKVIGSSMREDVCGVCGGNGQHCRNINGVLNKRANRKVNNYMRLYKIPAGARR
INIRETSSSSSFNLLALKSRQGRRYTLNSRSYRIQTRDTPHKFVSAGTLWHYDVINGLES
ITAYGPTNSDVILLISVQRRASRVSVAYSYVMHVNSLPRSHETFRYAVKRWTVCSVTCGA
GTKRARYGCRSSRNGGRWVSKRNCNGRPPRPEKKICSTTCTVTTRWFATPWSACSKTCGN
NGFHTRAVTCRQINPDATTQLVSAAMCFGQVKLPTQKTCTVSPCPPKWRTGAWTKCSKTC
GEGIQQRRVICRSSNHSLTSNHECPQPQPPDVRECQLVACSAPAVQSTETCVKERWLFCR
YGIQHCGIREYQKLCCLSCHNYTGVAGQP

>Ciona intestinalis_(ENSCINP_30146)
MSMLKIVFLFVFLSTVGAGDVGKDVDFVIPVRMEEDLSRVAGSKHFKSRHTVTHETTSKH
TVHEDEFTRPVYKIPAFGKDLLVRLEKDNSLVAPSFTTSYSYSNETVNDMNTFKQPLLRH
CFYKGTVLGEPESQVALSICDSLTGSIYTDSAHYMIKPTKNAHLPNKAYHSVHKRSVGRW
RPEIEETPHCGVRDTKHESTYEKTFLNSPLEELENMVSKITNRVRRSISTSENFKEPVVA
EGVRAKSRSKRAFDSQQHYIETLVVADASMVEEHGDDLEHYILTLMMVANRVFSHPSLGS
AISISVVKIMVLHEDSDGPRITQHAQHTLREFCSWQKRHNTPDDSDPQHYDLAILLTRTN
LCGDTCATLGLAEVGTMCSRRHSCAVIEDDGLSASYTIAHEVGHVLNMMHDDNRLCRANF
ANIDSTSHVMSPTMDRVDSEQPWSLCSKQALTDFLEDGGGACLLDRPQEPRVYPSQYPGA
MYDVNAQCKMAFGEGAVECPYMRECGRLWCQFPTGSRANRCHTRSFPRADGSDCAAGMHC
MQGRCVAKVAAVRPVDGHWGRWGHFGACSRSCGGGVQMSSRQCNNPEPRHGGKYCIGSRL
KFSSCNTNPCQPVAGRPVRDYRSEQCATYDGQRFPLLGVQTASTWMPKYTDIHTRDRCKL
TCQSVQTGAYITLADRVVDGTRCGPDTTNVCVHGQCMPAGCDGILGSKANFSKCGVCGGK
NSDCKRIRGKYNKRVAGYNNVITLPVGAASIKIEQRGFHNKVYDGNYLALKKPNGQYILN
GALILSTIKRDIEVNGTVLQYSGVDVPNERIHATMPLKEPITVQLLSVGVAGSKLLPPRV
KYSYYVSAPKRRASRKSKAKVPSSRSAVSDGSLVNRGIGRRIKSPSATPGSNHGPPRWVT
GRWRKCKAYGKRKCGSGWQKRSVTCKQGKRRARGCTGSKPFDRLPCFINACPTVSTNGRR
NHSGRSRPSPTERPIWNSGSWGPCSRSCGLGTKMRLVRCQTRSGHVLSESRCEAGTRPSE
AHGCRLRNCT

>Ciona intestinalis_(ENSCINP_14955)
MSASLSSKHIQRRQELLLRNFEELSKASSEATIHTIRPQRIDRNGGFIEFATLDPISSRS
GGKLRKRRSVEATNVLDTLDAAAATADGNHEVFYDLGEAPGSPLSGAKLRLTRNYKLVSK
NFVVEERSRAGKIRSRHTKLEECHYVGVIHNHNSFSKVALSLCNGMQGLITKDDDTFFIE
PKWNHTSNSTSSEFSTTASPQEVEEGHPHVIVKRSAIRRLMEKTENDDELGHCGNADHRT
SAGRRRGLEEDSTEEVTNEEDIAKSRGKRSISTERNVETMVVADKMMMVTHGKQELEKYI
LTIMNIVASFYHDASIGNAINIIITRVIILTEDQPNLEISTHAGNTLNSFCEWQAGVNIN
STGDSSDSGLAHHDNAVLLTGNNICANDFAPCATLGMANVGGICENERSCNINQDTGLAS
AFTIAHEIGHNFDMEHDGTNNDCGPRNGEPSQIMSPQLTKYTSPFSWSSCSKKYITDYLD
SGSGDCLLNTPPQRDFDFPSELPGQLHDADEQCRLQYGASSRQCKYGDVCRELWCISKLG
YCVTNSMPAATGTNCSEVNRGWCYRGHCVPYGYRADSVDGQWGEWTSWGECSRTCGTGVS
SSHRSCDSPAPEHGGKYCLGGRKRYRSCNTQECPNPKSDFRQEQCARFDTEPFQGRYLNW
IAFDGGYQVKPCALNCKPEGYSFYAERAGAVIDGTRCFSNSLDMCINGECHHVGCDHVLH
SDAVEDKCRVCGGDGSTCRTEAGVFNLPVTRTQYQEVITIPKGSVNIFIQELEISVQNYI
ALRNTRGDEYINGGWAIDWPRKFDIAGTTFSYKRPAGEPESLQALGPTTEDLVVMMLLQE
PNRGLRYEYNVRVEREGSAGAESAFLWSHGDWSPCTASCAGGTQRRPIECRRVDDDTVVQ
HSYCNSDTMPSEQVQTCNAEPCPARWITGSWGQCSRSCDGGHHVRTVVCMRAITQTEDEV
VDDRYCTDRKPWSTGSCGTEACPARWHTGDWSRCNPSCGAGWKTRVVTCASANGDETYDD
SQCDVNQKPTVKAHCMGRACRAKWVTYKWGQCSATCGRGTKRRRVVCIDPVTNRASNTCS
RNKKPKTTVSCSSSSPSCVRSPVRAPAAGRCIDDPSVAYCPLVLQFHYCNRAYFRKACCA
TCSKS

>Ciona intestinalis_(ENSCINP_19338)
DFQVVVPFRTDSTYNHLTNHLPHKRIRRDSDDVRRDVSSAAGDELHYVIPGYGERFELRL
LPNNALLAPTFSVKRIKREAEETEENIEQWGCHYHGRMTSHGKRRVAMSTCEGLTGLLRT
SEDDFLVEPLPHHINHTFPDRQHPHIIYKRRHLYKHRLHYCGKKKRFINYRKLHLVAVIF
KRETRTKHNRFKLRFYCRSSDNTRYRKPSNHQTLIFNDVSNRVNATRPTAKNVETLVVAD
AQMIRNHERDHRDITTYILTVMNMVSGLFSDRSMDGTINVVLVGIMLLEDNGALHLDHKA
DEALSSFCHWQANLNNTNGGKPDHSILLTGIDICVDKNKPCETLGLAQIGGMCSERNSCT
INEDMGLGLAFTVAHESGHSFGMKHDGEGNLCSKRDGHIMSPTLNGLNGVFTWSTCSRNA
IGDFLQNVESQCLDDHPSPMANLNFPDQLPGEIYDAASQCKWQFGADAITCIFRFNKASV
CKVLWCQRSESSRCETKYMPAAEGTNCGNNMWCRRGVCVTYGDPGPDAIDGGWGDYASWS
PCTRTCGGGVQHRMRACNNPTPRYGGRHCEGEEKIYKLCNTEPCAPNQVSFREQQCAQYN
RRAYRRQYFHWTPFTKYSSFGRDQCELLCKAEGYDFFDMLADKVIDGTPCDASSTDVCIQ
GKCKHVGCDFVLGSNATFDSCGVCNGDNSTCQSFNGSYDDNVRDSGYYDVIRIPRGARSV
KIWENKCCTHSYIAVRSASNSDRYYLNGNWEIDLYGETTFAGAKWFYNRKSFQSETLLTP
GPLGEELLIQVLVVAQNPGISYSYTTQVIDNRLPGLRTNSAIQVQPPSYNWSSTSDSCSA
TCAGGTQTVHISCVMDGTTVVDESHCDRPSRPSLTKECNTQACPARWHTTEWGQCSRTCG
GGLQLRQVTCKSKRMNGDVYVGESHCNNKRKPPRTQQCMQTECPAYWHTGEWSKCSRACG
RGVRNRHVRCRSGTRSLRNARCDRRVRPKSREPCLVTYCQRKYQWFITAWDQCSVTCGEG
IQRRELKCSFKGRNGRYRPVVARRCRRARRPEVSLEKTCTLSTCPSPRRISRRRSARWIV
GTWQKCSVSCGGGLQMRAVRCLQFGRPSHSCSISSKAPNKRACNTYKCRKKIQTACEDTF
KWCYLVPQHGQCSHKYFGVACCKTCKASSGNR

>Ciona savignyi_(ENSCSAVP_7277)
LVSQNFIVEERSKGGKIKSRHSKLEDCHYIGVIHNHDSFSKVALSLCNGLQGVIAKGDDT
FFIEPKWNHTMNETGEGPHPHIIVKRSTVVRVDEKKAEVGHCGNTGKFVFIRLVNMRFKH
DLAESERGEQDKHTEKRSRRESNSADFDSFSNHRTSAGRDRILGGRRSKRSVSVERNVET
MVVADKKLMITHGKQELEKYILTIMNIVAGFYHDASIGNAVNIIITRVIILTEDQPGLEI
NNHAGISLGSFCEWQAGVNINATGDSSDSGLAHHDNAVLLTGNNICVNSYEPCATLGMAN
VGGMCESDRSCNINQDTGLASAFTIAHEMGHNFGMEHDGPKNDCGPQSGKPSQIMSPQLT
KYTSPFSWSVCSKNYITDFLDAGSGECLLNSPPQRDFQLPTELPGQLHDADEQCRLQYGA
ASRQCKYGDVCRELWCLSRSGYCVTNSMPAAEGTNCSDITPRGWCYRGHCVPYGYRANSV
DGQWADWTSWAECSRTCGTGVSSSHRSCDNPAPEHGGRYCVGGRKRYRSCNTQACPNAGS
SDFRQEQCARFDTEPFQGRYFNWIAFNGGYQVNPCALNCKPQGYSFYAERAPAVVDGTRC
FSNSLDMCINGECHHVGCDHVLHSDAVEDKCRVCGGDGSTCHTEAGVFNQLVTRTQYQEV
VTIPKGSVNIFIQELEISVQNYIALQNTNGEEYINGGWAIDWPRKFEIAGTMFSYKRPAD
EPESLQALGPTTEDLVVMMLLQEPNRGLKYEYNVPIAREGSTSGEESAFLWTHGDWTPCS
ASCAGGTQRRPIECRRIDDDTLVQHSYCNPATMPSEHIQSCNVEPCAPRWISGSWGHCSR
TCGGGHHTRTVVCMRAITHTEDEVVDDRYCTDRKPQSTQSCNDDTCPARWHTGSWTRCNP
SCGSGWKRRSVTCASADGLETYGESECDVNQKPSIRARCMNRPCRPRWIAGKWGQCNPSC
GSGWKRRSVTCASADGLETYGESKCDVNQKPSIRARCLNRPCRPRWIAGKWSQCSGTCGQ
GMKLRRVVCVDPMTKRPSHACFYSRKPKRIISCNAKCEETEVPPEECADNLAYCPMVLQL
NFCNRKYFRKVCCHT

>Ciona savignyi_(ENSCSAVP_19260)
VYKIPAFGRDLLVRLTKDEALVAPSFTTSYSYKNQTIKELDTSHQPLLRHCFYKGKVVGE
PSSQVALSICDSLTGSIYTDEYHYMIKPVTKSGQEEASVKFHSVQRRSVGGGRSSQHQTP
HCGVRDARHTSTYQKTFLHSPFEEIEGSVQRKSRSKRSFDSRQHYIETMVVADAGMVREH
GTDLEHYILTLMMVANRVFAHPSLGSAISISVVKIVILDEEANGPRITQNAHHTLHDFCS
WQKRYNTPDDSDPQHYDLAILLTRTDLCGDTCATLGMAEVGTMCSRRHSCAVIEDDGLSA
SYTIAHEVGHVLNMMHDDNRLCRANFANVDSTSHVMSPTMDRVDSEQPWSLCSSQALTDF
LEDGGGDCLLDRPQEPRVYPSEYPGAMYDVNEQCRMAFGEGAVECPYMRECGRLWCQFPT
GSRANQCHTRSFPRADGSACAAGMHCLQGKCIPKVEQMQPVNGRWGRWSQFGACSRSCGG
GVQMSSRQCNNPAPQHGGNYCIGSRLKFSSCNTEPCRSINGRPVRDFRSEQCAAYDGQRF
PLLGVSIASTWLPKYTDIHAKDRCKLTCQSIQTGAYITLGDRVVDGTRCGPDTTDVCVHG
QCMPAGCDGILGSKARFSKCGVCGGRNSDCKRVRGKYNKRVSGYNNRTLPCPSERRRIRI
ERTRSYDGNYLALKKPRRTIHSANGALILLTMKRDIEVNGSVLQYSGVDVPIERIHASMP
LKEPITVQLLSVGVAGSKLLPPRVKYSYYVRSAKRRASRKSKTKKVSSSSAIFSPNMAGR
ITPSSVAPASNQDPPRWVTGRWRKCKAYGKRKCGSGWQRRSVTCKRGKRQNRCPTVPSRG
RSSHRPRPRQSEKPIWVVGTWGACSKSCGLGTKMRIVRCQTRGGDVRAESRCGIGIRPSE
AHGCRLRNC

>Branchiostoma floridae_(XP_002601614)
MFRRFTIVLAMLCQLLLIAATTCTGYGLDGPGERTFHFPDEKQGNFADGLSSYDVVHPVRVSPDGEFISH
RVVHSEHHHLHRRGAGDQGRPSSSQADGLHYKVTVDGVDLHLDLRLNPALLAPGYVLERHRGNVSRAAVT
RGPTNPCHYVGTVPTSRDSSVAISTCSGLRGLIRTGKDDYFIEPVRGHNVSAAEKHPHLIYKRSALPKEN
QPSSSPVYEGEHSDFCGLEGNRQRDETRRERWENKHHNHGGEQHGSRPRAKRSVSKERFVETVVVVDKKM
VDYYKDDDVETYVLTLLNMVSRLYHDPSIGNLINIVLVRLMLLEEEPEDLSISHHADHTMSSFCKWSKSI
NPKDEVHPNHHDVAILLTRYDICTGMNEPCGTLGLAQVYGMCQPHRSCNINEDTGLAVAFTMAHEIGHNF
GMKHDDEKSGCQTPPHQRPHVMSHLLTTQTSPLAWSNCSRATITTFLDRGWGSCLDDQPSEHDFTFPTLP
PGMMYDADHQCRLQYGPTASLCYGMSDVCNTLWCNVVETNACHSKLESAAEGTRCGHNKWCNRGNCVAVT
GAPPVVDGGWGTWSEWSDCTRTCGAGVQHAIRSCDSPRPSHGGRFCLGQRKKFRLCNVEACPDGEIDFRE
WQCQMHDEKPFKGNYYSWVPVAYPQYPCELHCKPEGSFFSARLAEVVIDGTPCRKASRDVCIDGICKPVG
CDFILGSNATEDRCGVCSGDGTSCETIKESYNEKEGRGYVEATVIPAGARNIRVEEVAEANNFLALKGHD
GEYYINGHWFIQWTGEYEAGGTTFRYERHGNREVFTAPGPTTEQLHIMLLFQEKNPGVVFEYTIPREQND
TDGEPTRVPDFSWEFSDWTECTATCGTGTQRSRVMCVEKEAGQVDPRFCNATNKPDDKLRTCNEDRCPSR
WWTGPWQHCTASCGDGGTRTRSVLCIRSIGPDEQMALPFVECLALPKPPHEETCNKDVPCPFSKWIPGPW
SECSKSCGGGIKIQSLTCKDNATCDPDVRPKTVLCNIHVCPPDPTTKSTTADISTTDYITTEPENTPLRG
TTQFLPTGKVGKSREDNSLHESEKKRNYGHENIITRFRAFMMGDDAHVEDKPFLKRLPPSKPESSSVAHT
MKSQTEATTPITTATLTLGTLSGEKQVITSWSSLRAMSSTPVIVDRTNDPSKVAMVRTELRLKTETPTTS
PTTVLTERISTHPQMATQATAATLSVTVSNGTVRHRHEMHSWVTGNWSECSQTCGHDVQERDVTCSRPHQ
CEHSKKPIQQRPCFVRPCALWVTGGWSECSASCGGGQQRRQVQCQDLVTRRRSQGCDKRRTPANVQQCNL
EDCPSENSAQSRCTGDLNRPHLCNIVVRFRRCHMPQFWAKCCKSCGDPVVSHRTHRQKRTSQ

>Branchiostoma floridae_(XP_002601301)
MAAVQLQPVPRVLALLLAGLFFLALASGARHNSQVVFPRRVQRDQTGSPWRGDRGRVARDAAQGTSGDPQ
DFVFYRMDAFGKTLLLRLTPNKEFLSRSFQTLTLSGDGRVVDMSGSTGACFYSGTVESFHSSSVVLSTCS
GLMGLIKVNNEQMLIEPLSQRRRYFGGRPHRIYRRELPQASVTQFCGTEPDDRESEGEDESRQTKRSAVN
NIDARQRTVEALVVLDKTIVKHHGRALVKTYALTVMSMVNSVISLPSIGHNINIAVTKLVILEEDQVLTD
VPRYGVQVFPLQTAALFPEVSGQLAVHGRKDICKDRDEPCGTLGMAFISGMCDPNRMCSVNEDNGLTLAF
TVAHELGHNLGMNHDGMENRCVTRPESSIQYIMSSSWLRRTGKVNLQWSPCSRSKVENFLRSQQSQCLLD
TKRGANLGYAAELPGELYTPEQQCVFIFGKNASVCPYPEKKIRLCESLWCIEPGKDECVTKEFAAVDGTE
CGQDKWCKGGRCEYNKDPVHGGWGNWTDWSGCSRTCGTGVRFAARKCDSPFPEYGGHSCGGDRVKYEICN
TQPCPEGSPSFRSEQCAAYRQQHARQNKTKSSLWFPVYSEESPCSLLCRAVSGRRRTVTLSDRVIDGTPC
SPGKRALCVDGQCKRVGCDDVIGSDAEEDQCGVCRGNGTTCHLVRGMYQHHRGTGYEEIVVIPKGARRIR
VMEARPMRSYLAVKDSVTNRYVNGGRRIELPKTFKMAGTKVQYTRKDLWETFTAEGPLNNSLQFLILQQD
PFVGVVFEYTVDLDNASHEESPTVNNYKITTDLDSFSEDEPTYGWIPDGWEDCDAVCGGGIRRGRNRCMQ
LLLKNRSLTYVEDEPCRDLPRPHQKEERCNKAPCETKWRMAGWLPCSVTCGEGTHRRVVACTQQLSNGTL
RATHPDNCEGSRPPAEKPCRLNSCPLVESRWKESSWGQCTVTCGGGIQSRLVRCVGRASDGSERYVGEAQ
CQEKKPAETRECSNRSCEDFYEWRTDAWSPCSASCGPGVQLRNASCVQLLENDTDTTTVPGRLCFAPKPD
VIRNCTYGSCPIKQVKWEVSAWAGCSVSCGQGMQSRDVTCMTSYTNGTVLTGDDLCDIPKPAPVRSCGFE
PCPISESWEATPWHACSVTCGQGIRSRRVRCKVTYPNGTMVYAPDVRCNDTDKLRTLKPCFGMECAAKPI
EIVWSKCSTKCGPGERTRRVKCHQDDALCKVKYRTVRRVACFGSRCNGVWKTGPWSKCSVTCGYGLQHRS
IRCKTDRSDKTWYHNCNKHDRPDSTRSCSAGSCVNAFDLYVYPLQPPNVKEPRRCNRDQANPRICRVVKT
RGRLCRHTHWAKNCCRTCGYYEIV

>Drosophila melanogaster_(FBpp0082613)
MSMPDAGSLKSPAGGQEVECHRLLSDLPAFAYPSTTLRSTTSGHSTGTNSTTVCESPGAR
DRTSFACSSSCVSSACSATASDDDEDERALERCLRGTTDDLGESGLRYSLKGPPPELYSA
KKDFISKGPLLGRQLEVKKRCEWWCHKYIQKMSTHWRQNACLYACCIAFLLGMLIMFHLG
LRSAHKGQEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAFV
MPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNV
FGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPH
SMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVLHRVFRKSQRNARHAVSKFELGLDD
FMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYIL
ILMSIVSSIFADASIGNSIRILLVRLISLPNINDQTHSSNEMLKHFCQFINQSGYERDTA
MLITREPICGSVPGKICHMLGLAELGTVCSSSSCSIVQDTGLPTAFTMAHELGHILNMNH
DDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVG
AHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLP
WADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQ
PVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY
EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDK
CGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQN
FIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQI
ISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACI
STTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQ
TFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHN
SRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEKTRS
VSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGT
RKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTRDVRCES
FQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQCNCEGVEKRRDFCFNSHKGRIACP
TRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSRSLNSIGGSRNRGTPRSCADLK
EMHGYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQENYSIYYEYRTKQTNSCPP
ESRGHEYYNDQNSGRTHFRKLRLNITDLRIMDNDFKFADSRGLAQKLGSAGDCYNRIGQC
PQGDFSINMKDTDFSIRPGTVWRMHGQYSVMKRISEFDTTTQMRRGFCGGYCGGCYIAPD
SGLYLDVL

>Apis mellifera_(XP_006561641)
MSRVSSRASVVAAVISIVLLIVVFLVVVLWAGARTKKEEEMAVDGRLVVEVLDSLSGVRVGNASSTTVRG
VRMLEEEEEEEESFGNEVISHSERSSRRKSDSKKTKSFSRKPDLEYVQLMKLAENQYEDPPSEFSAKRRH
SGHFRPATAEVWDSRPQYEFTAFGRRFRLLLAHDTSFVSPNIKITRITENTSRRENPGPELGCFYSGTVD
GDPQSAVTVNLCHGMTGHVRTSTGSYIIKPAKPWRESDEQDSLEFSLEHAVQRIKPYTVVDATKDDDDDR
VGAHNCGVIDDNTPTPIVENSSKGKIYFDGRRRKRRSLTEKKELERSEEDEMYKQFVGQAEGHRNFLRND
ARYYSVERRRNDLSEEYGQDSEMESDPSVTWRPRRALSSEYFIEIMVAADAEMVRYHGKGLLGYILGLMS
TVSRIYKDPSIGNPISISVMSIVPIDKIFGVRRTKGEGIAAADMLNKFCRWQQSNNPNEYSPGHYDTALL
LTRENLCHNSDQRNCDTLGLAELGRMCSPRSSCAIVQDNGLAAAFTIAHEIGHVLDMPHDDDVKCAAYKN
RSGMHNIMSRMLDDNTFPWEWSKCSRHYVTEFLEAGKGDCLLDTPDKIMERTDPRRLPGEDYSVNKQCEL
VFGNGSRICNHMVGDVCRRLWCTTPNEDHYDHCRTQHMPWADGTSCGRDKWCYRGECVSRSLNLQPVDGQ
WGEWGRYGKCSRTCGGGVKKKYRECDNPLPQNGGRYCIGEQVKYRSCGTRECPPGTPDFRDQQCSYFNNN
NLNIKNLSRDVKWHAKILPHERCKLYCETDSNQCYPLAEKVIDGTPCDQDTFHICVNGFCKPAGCDHVLN
STAELDICGVCKGDNSTCQWITGSYNSTQYGYTRIAKIPAGSNNIDIRQPGWKDMIDDGNYLALRLGEGG
KYIVNGNFKVMTQRVIVDIGVTIEYSGRDSRVERLNTSRPIETDLILEVLSVSELNPPQISYKYTVPRKI
LESYEWKLSGWSDCTRTCQGIKYRKAECTNIEYKEVVADDYCRESEKPREESQMCNNHCVLEWNITVSEC
SNHCGLGTRVVTSRCIQKLLNSNHPPRAIPPHSCAHLERPNETESCMGPCEDAHWSYGKWSACNATCGGG
IQYRTATCIDSNQRTVSEENCMGQRKVLENACANDPCPKWTFKNWSNCSVTCGIGKQYSRYACHIENRVV
PDNYCGKPPLEITQACNSGPCEQWHKGDWSACSVTCGEGIKRRKVICKTLDGITSNKCSASNKPDNITAC
ILKSCPTVNVTPIKYSSDPPYEIPSQQDNEVHDIIFHYGYKWHTETQKCSKPCIKGYMNTTVKCVSIETG
IVAPDRYCDNEKKPSTEIPCNRFHCPIWITSDWGQCNVECGLGTQYRRVYCQNPQGESISDENCHESEKP
EAEKTCRKRLCVNILRKWRTSNWTPCSKECGQGIQTRTVSCHRVNRYGLIDPTPTDSCPIDQKPENQQFC
KLRECDDKYYWYAGPWKKCSHACGQKGRETRRIFCLDRNGRKVARYKCPKRFKPQRKQKCNQRKCYAMSC
LEVKKYFKTTKDSEYNLVLGGRSMSIYCHGMLTSEPKEYLTLPAGPQENYAEVYDKTFNDPYVCPYNGPR
NNNCSCSTSGKTTFRRVRIDPVELYIIENDYTFSWMTGSNRVEYGTAGDCNSIAHCAQGHFSINLSGTQL
KLSSSIVWTATRGTSIKINHINSQHVTGKCGGYCGSCKPKNGLKLDVLPP

>Apis mellifera_(XP_006570598)
MRYPLMLQAFIVVVHIVPEARLHRPRGVYTVQGHGIHSHEIAIPRKVSERGVLISHNVTHHHHEDGPVVH
YRLSVAGNEYHIELAAVEKFIGPGLVVERRKRDVHVRARPKNSSSKCHYRGFIRGHANSRVALSACDGLA
GMLRGDHGEFWLEPVALSPEEERVRLEEERLEDAGAEGRGAAGLYRNSVLGRPHLVFRRSVEQPQLEIGA
AGRARRRRKKKKKLERNCGTREPRRLTETRLEWQTQPGLVQVQGRGRRKQHQTRRWQRSKRSISRPRHVE
ALVVADTTMMAFHQDGDVETYLLTIMNMVSSLYLDPTIGNFINVVVVRIILVEEDDAEQGLDITVNADRT
LYNFCKWQQKLNPADDSHPNHHDVAILVTREDICSRANTPCSTLGVAHVAGMCQPDRSCSVNEDNGITLA
HTITHELGHNFGMYHDTEKIGCSKRDGDTLHVMTPTFEVDTIGVAWSRCSRRDITNFLDQGKGECLEDEP
ADNDYSYPDLPPGAMYNAEHQCRLQFGVREASVCSPLQEICSKLWCIVDGTCTTMLHPAAPGTHCGKHMW
CQNQECVPIVDRPRQIDGGWGEWGSWSECSRTCGAGVSIVERKCDHPEPAHSGKFCIGERRRYKICNTEP
CPEGTSSFRAVQCSHYDDKEYKGKNYTWLPYFDQTEPCELYCTDTEESVIVPWGEAALDGTPCNVGTRDM
CIAGICRKVGCDWTVDSDATEDRCGICHGDGTQCETTGGVYDKNDGPGYKEVIIVPNGSRNIKIEEIGNS
KNYIGIGVPNSDKYFLNGKRQITLAGEYEVAGTPALYERDRDREKVRIPGPIKEDIAIYLISRGHYRNFG
LRYEYTVPKKEPDRAPEYSWVFSDWSLCTATCGGGTQTSKPFCNEKKSGVVEEHFCESIEKPETKLRECN
LNPCPARWWFGPWQMCPVTCGEGALRKRSVMCVSSGVGPDRSDLALPDRDCNRDVRPEEVSPCPNLPPCS
STEPPLIVYADNKDASFYNVSSNDQNGITIVDGLTTEEPEILEFDNVVDENPGNSMYDTKSKWISSKWSH
CANGKRTRKVTCSEQGECNPENKPIAVELCQGARWITGRWGSCNASCLARVGVKRREVECRDRITELLSD
DCNPERRPIDTRRCYHRRQCANDKSECKDTIVPTSMCASYKRMCDVSLIVQDKCCATCFKKRRHGRHNKR
HIFDD

>Hydra magnipapillata_(XP_002169841)
MNINGMIYDLSNSVLERDLDVQPDMRWKHQLQIELDPNSCNIDVPCAKNVICWKKRDPLVRVDRSSDDSA
NFVKSDNTERYIETLVVVDQKMVNYHGEDAATQFALVVLNIVSSLLRDGSIGSNLIILVVVKLELHTVDI
PGLVINHHARNTLESFGTWAARASDQDDRSDDHFDYAVLMTRYNVCADDRQPCDILGLTQVGGMCNWPYS
ASINEDNGLPLAYTITHNIGHSLGMNHDGDESSFICPDNTFLMSSLSTPIQEWKSSHSLWSRCSRNYLKN
FLKKDQAKCLLDPPVKAKSVDYEKMDNKPGLLYDLHKQCEMQFGTGSKLCHQNDMEKICSKLQCTNPANP
DKCFTSSYPAADGTTCSLSKFCYRGECVSAGDVKAIDGGWSSWSDEFSACSRSCGGGVQYRHRQCSHPKP
SNGGKYCEGEARMYRLCSKKPCDTGLKSHRSVQCASLDGRLFGERKFEWEFKPSKIESCKLGCFIAGTGH
GYDFGNVEDGTNCDQMDSSVVADKCINGECITVGCDSVLGSKAKFDRCGVCNGDGSSCATGTDRSDIPEI
STGSGGIAEALKSLKEMGFDMGSFYSKSQLSLAEKRSDIPQKDDTNFGWSRIKSGCSTSCGGGVETVTPE
CRRLDDGSPSNEDRCDKKTKPPVQQYPCKEDACPPM