>Homo sapiens_RAPGEF2(ENSP_264431)
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE
TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS
PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF
SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY
SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI
QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA
QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV
ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR
SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
>Pan troglodytes_RAPGEF2(ENSPTRP_28421)
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE
TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS
PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF
SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY
SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI
QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA
QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV
ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR
SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
>Gorilla gorilla_RAPGEF2(ENSGGOP_24246)
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE
TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS
PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF
SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY
SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI
QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA
QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV
ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR
SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
>Macaca mulatta_RAPGEF2(ENSMMUP_13870)
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
TTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE
TSPVAPRAGSQQKAQSLLQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS
PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF
SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGVGRMERRTMMEPDQY
SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI
QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA
QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSITSVTTEETKSVPMPAHIAV
ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR
SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
>Mus musculus_RAPGEF2(ENSMUSP_114119)
MKPLAAPANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSCS
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFS
TTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPE
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
VATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKKFEEVINQETFWVASEILRETN
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
QDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDVAQTGGHKKRVRRSS
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATSTLPKNPGDKKPVKSE
TSPVAPRAGPQQKVQPQQPLAQPQPPHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSP
QALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFS
DSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYS
LGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQ
TIQHQRSWETLPFGHTHFDYSGDAASIWASGGHMDQMMFSDHSTKYNRQNQSRESLEQAQ
SRASWASSTGYWGEDSEGDTGTIKRRGGKDVSAEAESSSMVPVTTEEAKPVPMPAHIAVT
PSTTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARP
TEAPAPGQTPPAAAASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV
>Rattus norvegicu_RAPGEF2(ENSRNOP_37119)
SQLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGL
PETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFAN
MTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNS
FGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHR
ELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLE
WFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACA
AKAKRRSMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSSSKATEAGLKRGDQILEVNG
QNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKAS
RYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQS
QDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTPDLPDQVLRVFKADQQ
SRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADR
IQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEP
TEYIDDLFKLKSKTSCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHC
RECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLS
GQNLQPPVIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPA
LMFRTRKKKWRSLGSLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVK
QYLSNLELEMDEESLQTLSLQCEPATSTLPKNPADRKPVKSETSPVAPRAGPQQKAQPQQ
PLAPPQPSHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERH
RKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFSDSGHSEISSRSSIVSNSS
FDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSESRGLYAAAT
VISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHF
DYSGDATGIWASGGHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEG
DTGTIKRRGGKDVSTEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGLIARKEGRYREP
PPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPGQTPPAATASRP
GSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV
>Bos taurus_RAPGEF2(ENSBTAP_29739)
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
TYRTFLCSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPAREAPLPFILLGGSEKGFGIFVDSVDSAS
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTATPDQYSLCEVSVTPE
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
VATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKTFEEVINQETFWVASEILRETN
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPTDKKPVKSE
TSPVAPRAGLQPKAQPQPQPPQPPHKLNQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQA
LKKILSLSEEGSLERHRRPAEDTISNTSSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDS
GHSEISSRSSIVSNSSFDSLPVSLPDERRQRPSVSIVETSLASGRLERRPAVEPDQYSLG
SCAPLSESRGLYAAATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTI
QHQRSWETLPFGHTHFDYPGDAAGLWASSSHMDQIMFPDHSAKYSRQSQSRESLDQAQSR
ASWASSTGYWGEDSEGDTGTIKRRGGKDVSLDADSSSMTAVTAEEAKPAAMAAHIAVTPS
AAKGLIARKEGRYREPPPTPPGYVGIPITDFPEAHPHPARKPPDYTVALQRSRMLARPAE
PPAPGSARPAPRPQWHRPGDGDPRAGPCAPPGLTAEEDEDEQVSAV
>Loxodonta Africana_RAPGEF2(ENSLAFP_0251)
LRGIFYLEKEAFSTQEMAFLVRCYANCLQPWSSKLPADFTKLHLADSLHPQVTHVSASHS
GCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDI
VRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLND
GEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMKTKVDDCQFVCI
AQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEE
HSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEG
DPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFLLLGGSE
KGFGIFVDSVDSGSRATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTN
LFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANT
VGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSN
PDLLQSHHRILDFSTTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTTT
PDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELL
RESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKTFEEVINQ
ETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTW
EKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDS
KVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNAAVLDV
AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEDSLQTLSLQCEPATNT
LPKNPGDKKPVKSETSPVAPRAGSQQKAQPQPPSQQQPLPHKISQGLQVPAVSLYPSRKK
VPVKDLPPFGINSPQALKKILSLSEEGSLERHKKPAEDTVSNASSQLSSPPASPQSSPRK
GCTLAPSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERHQRHSVSIVETSLGVG
RLERRAVMEPDQYSLGSYAAVSESRGLYATATGISSPSTEELSQDQGDRASLDAADSGRG
SWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPPGLWASSSHMDQIMFSDHSTKY
NRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSVEAESSSLAPVPTE
EAKPAPVPAHIAAPSSTAKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPD
YTVALQRSRMVARSSEVPGPSPVQQPHGHPASSRPVNKPQWHKPNESDPRLAPYQSQGFS
AEEDEDEQVSAV
>Taeniopygia guttata_RAPGEF2(ENSTGUP_5920)
LPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPE
TAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMT
MSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFG
VSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHREL
DRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWF
NDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAK
AKRRLITLTKPSREAPLPFILLGGSEKGFGIFVDSVDFGSKATEAGLKRGDQILEVNGQN
FENIQLTKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRY
SIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQD
DSIVGLRQTKHIPPALPVSGTLSSSNPDLLQSHHRILDFNTTPDLPDQVLRVFKADQQSR
YIMISKDTTAKEVVIQAIREFALTATPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQ
LSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTE
YIDDLFKLKSKTGCTNLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRE
CKNFNSMFAIISGLNLAPVARLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQ
NLQPPIIPLFPVIKKDLTFLHEGNDSKVEGLVNFEKLRMIAKEIRHVGRMASVNMDPALM
FRTRKKKWRSLGSLSQGSANAAVLDVAQAGGHKKRVRRSSFLNAKKLYEDAQMARKVKQY
LSNLDLEMDEESLQTLSLQCEPATNTLPKNTGDKRSGKSETSPVAPRAGIQQKVQQQHKV
NQALQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLDRHKKQSEDTVSSA
SSQLSSPPTSPQSSPRKGYTLAPSSTVDNFSDSGHSEISSRSSIVSNSSFDSMPVPLHDE
RRQRHSVSIVETNLGVGRIDRRIMIEPDQYSLGSYAPLSETRGLYAGATVLSSPSTEELS
QDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHAHFDSSGDGAGLWA
SGGHMDQLMFPDHGTKYGRQSQGREGLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGK
DVSIEADTSSITSVPAEETKPAPVPPHTAAASSSTKGLVARKEGRYREPPPTPPGYVGIP
IAEFAEGGSHPARKPPDYNIALQRSRMVARTCETHGTATPQQQSHGHSTGRPVNKPQWHK
PNESDPRLAHYPSQGFSTEEDDTEQITQI
>Xenopus tropicalis_RAPGEF2(ENSXETP_26249)
QDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSV
FIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQSRRR
FRKINQKGERQTIIDTVESYPVGKPPLPRGYHTLPADFTKLHITDSLHPQVTHVSSSHSG
CSITSDSGSSSLSDIYQQATESEPGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDI
VRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLND
GEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCI
AQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEE
HSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEG
DPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAPLPFNLLGGSD
KGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTN
LFVFKELLARMLEEKRNSAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVSKKGKANT
VGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHMPATLPVSGTLSSSN
PDLLQSHHRILDFNTTPAEQPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTA
VPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDL
LRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLKMKTGCTNLKNFEEVIN
QETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTT
WEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGND
SKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTSGKVLLSLKRSLSQGSTNATVL
DVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSDLDLEMDEENLQTLSVQCEPAT
NTLPKNPCEKRAGKPDTSPVAPRAAAQHKQQQQQQTKVNQALQVPAVALYPSRKKVPVKD
LPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQCSPRKGYTMA
ASGTVDNFSDSGHSEISSRSSIVSNSSFDCVHLHDDRRQRHSLSIVETNLGVGRADRRAI
IDADQCSLGSYAPVAETRGLYAGATVLSSPSMEELSQDQGDRASLDAADSGRGSWTSCSS
GSHDNIQTIPHQRSWETLPFGHVHFDNTADGSGFWATGGHMDHGIFPDHSTKYGRYSQGR
EPLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVALEAETSSITSMTPEETKPLPV
PTHVAVTASSAKGLIARKEGRYREPPPTPPGYVGIPIADFADGHPPLSRKPPDYNVALQR
SRMMARRSESEGSAATSPPSHNQTSGRTANKPQWHKPNEADPRLALYQAQGVTEKDDADD
EQVSAV
>Danio rerio_RAPGEF2(ENSDARP_4657)
MASYVDNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEA
NEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVV
DYMDENEEYFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPVARGYHTLPADF
SRLHLADGIHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEPGDMDLSGLPETAVDS
EEDDDEEDIERASDPLMSRDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRR
ELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTM
EKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGT
RKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPSL
RDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRV
VTLTKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVP
LSKANEILKNNTHLSITVKTNLLVFKELLARPDQDQEQEQEEEPDRKNGAPHIPKIGDIK
KASRYSIPDLAVDVEQVMDLEKASKKAKANSAGGRNKLKKIFDKTLTSILPPKPYNDVGV
GQSQDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFNNQPDMSDQVLRVFKA
DQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEAYSLCEVSVTPEGVIKQRRLPEQLSKL
ADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCA
IEPTEYIDDLFKLKTRLTGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKI
ALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYR
NLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMAAVN
MDPALMFRTRKKKWRSLGSLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMA
RKVKQYLSNLTLETNEESLQTLSMQCEPSINTLPKSSGDRKRPDTSPVVSRAATHQRQQL
QKANQALQVPAVALYPSRKKVPVKDLPPFGTSSPQSLKKILSLSEEAGDRHRKQAEDSVS
NNSSQLSSPPTSPHSSPKKGYGRAGDYLSDSGHSEISSRSSLVSTSSLDMGQDERRQRYG
GTAGEGHGSGHRLERRATADPDQYSLGSYSSMQDCRGLYAGATVLSSPSSEELTQDQGDR
VSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWEALAEGAGLWGSRGSWASACSSSSSVA
CWGEDSEGDTGTIKRRGGRDVTTDPETSSITSTGSEESRQHSRRPSPITAGNTKASITRK
DGRYRDPPPTPPGYTALTITDVTEGTPHSGRKPPDYTTALQRSRLVTHSLDSQQPPAAGK
PDPRGREEDEAVEVEEEGECLSPKLRAQRRRGPHTAVPPRP
>Takifugu rubripes_RAPGEF2(ENSTRUP_9873)
SQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGSCWYILLSGS
VFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQSRR
RFRKINQKGERQTIIDTVDPYPAGKPPIARGYHTLPADFSRLHLADGLHPQVTHVSSSHS
GCSITSDSGSSSLSDIYQATENEPGDMDLSGLPETAVDSEEDDDEEDIERSSDPLMSRDI
VRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLND
GEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCI
AQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEE
HSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVLLWVNNHFNDFEG
DLAMTHFLEEFENNLEKEKMCGHLRLLNIACAAKAKPRLVTLTKSARDSPLAFSLLGGQE
KGFPIFIDTVEPGSKAAEVGLKRGDQILEVNGQNFENVQLTKANEILKNNTHLSITVKTN
LLVFKELLTRPEHDHDLDAEEEHDRKNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLE
KASKKAKTNTVGGRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIVGMKQSKQIPQPL
PVSGNLSSSNPDLLQSHHRILDFNNQPDMTDQVLRVFKADQQSRYIMIGKDTTAKEVVAQ
AIREFALTAAADAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETL
CSDEDAQDLLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKLRSKLSSAS
LKRFEEAINHETFWVATEVTREPNQLKRMKTIKHFIKIALHCRECKNFSSMFAIISGLNL
APVSRLRGTWEKVPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKD
LTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQ
GSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSKLSLETNEDSLQTL
SLQCEPSISTLPKNASGKRPDTSPVVSRAASQQRGQLAKGNQALQVPAVALYPSRKKVPV
KDLPPFGTSSPHSLKKILSLSEEGNERHRRQPEDTMSNASSQLSSPPTSPQSSPKKGYTR
MGDAYSDSGHSEISSRSSLVSNSSFDMAQDERRLRHSGLGESHIGGSRLERRATTDPDQY
SLGSYSSMQDCRGIYTGCPTVLSSPSSEELTQDQGDRVSLDAADSGRGSWTSCSSGSHDN
IQTMQQGRSWETLAFGGGGGGLGGLPPGGPDSLLGGSAALWAAQARGSWASASSSSSSAA
YWGEDSEGDTGTIKRRGGKDINADPETSSITSTGSEEAKQLGRPSPSPITAGGKGLLSRK
ESRYREPPPTPPGYTALSISDLGDGHQQPPTATTSTLTHTGRRPPDYTTALQRSRMVTQS
PDS
>Tetraodon nigroviridis_RAPGEF2(ENSTNIP_16020)
MKPLAPSDSNGVPSQQDKPPLPADFSRLHLADGLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATENEPGDMDLSGLPETAVDSEEDDDEEDIERSSDPLMSRDIVRDCLEKDPMDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPEGRTDILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLL
TYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFENN
LEREKMCGHLRLLNIACAAKAKPRLVTLTKPARDSPLAFSLLGGQEKGFPIFIDAVEPGS
KAAEVSLKRGDQILEVNGQNFENVQLTKANEILKNNTHLSITVKTNLLVFKELLTRPEHD
HDLDAEEEHDRKNSAPHLPKIGDIKKASRYSIPDLAVDVEQVMGLEKASKKAKTNTVGGR
NKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIVGMKQSKQIPQPLPVSGNLSSAGSNYS
CVCDCPDMTDQVLRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAADAYSLCEVSV
TPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLRESQISLLHLS
TVEVATPLSMRAFELFPIEPTEYIDDLFKLRSKSSSSSLKRFEEAINHETFWVATEVTRE
PNQLKRMKTVKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFG
DLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLR
MIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDVTQTGGHKKRVRR
SSFLNAKKLYEDAQMARKVKQYLSKLSLETNEDSLQTLSLQCEPSISTLPKNAGGKRPDT
SPVVSRAASQQRGQLAKGNQALQVPAVALYPSRKKVPVKDLPPFGTSSPQSLKKILSLSE
EGNERHRRQPEDTMSNASSQLSSPPTSPQSSPKKGYTRMGDANSDSGHSEISSRSSLVSN
SSFDMVQDERRLRHSGGSRLERRATTDPDQYSLGSYSSMQDCRGIYTGCPTVLSSPSSEE
LTQDQGDRVSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWETLAFGGGGGGIGGLPPGG
PDSLLGGSAALWAAQARGSWASASSSSSSAAYWGEDSEGDTGTIKRRGGKDINADPETSS
ITSTGSEEAKQLGRPSPSPITAGGKGLLSRKESRYREHRPRAPGYTALSISDLGDGHQHA
STVPASTATHTGRRPPDYTTALQRSRMVTQSPDS
>Gasterosteus aculeatus_RAPGEF2(ENSGACP_21953)
DLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVF
IKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVRNAPRRNLGLKRGSLSGRRGFIQ
LSHPCEARTAIEHEYVNVFLELPADFSRLHLADGLHPQGPHVSSSHSGCSITSDSGSSSL
SDIYQATENEPGDMDLSGLPETAVDSEEDDDEEDIERASDPLMSRDIVRDCLEKDPMDRT
DDDIAEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILN
GSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQV
EKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDF
LLTYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVLLWVNNHFNDFEGDSAMTRFLEEFE
NNLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRDSPLAFSLLGGQEKGFRIFLDAVEP
GSKAAEVGLKRGDQILEVNGQNFENVQLIKANEILKNNTHLSITVKTNLLVFKELLTRPE
QDHDADGEEEHDRKNGAPHLPKIGDIKKASRYSIPDLAVDVEQVMGLEKASKKAKSNSVG
GRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIVGMKQSKQIAPALPVSGNLSSSNPD
LLQSHHRILDFNNQPDMSDQVLRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAPE
AYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDDDAQDLLRE
GQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKHRSKAGSASLKRFEEAINDET
FWVATEVTREPNQIKRMKTVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEK
LPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV
DGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGQGSANAAVLDVTQTGG
HKKRVRRSSFLNAKKLYEDAQMARKVKQYLSHLSLESNEESLQTLSMQCEPSISTQEENE
RHRRQPEDT
>Oryzias latipes_RAPGEF2(ENSORLP_25047)
ADRPADRAADRAADRGHPVRTTKDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEA
NEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVV
DYMDENEEYFQRQASHRQSRRRFRKINQKGERQTIIDTVDVNSYLNLPADFSRLHLADGL
HPQVTHVSSSHSGCSITSDSGSSSLSDIYQATENEPGDMDLSGLPETAVDSEEDDDEEDI
ERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFA
VVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRTEVLCMGNSFGVSPTMEKEYMKGVM
KTKVDDCQFVCIAQQEYCCILNQVEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKG
TAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVL
LWVNNHFNDFEGDPAMTRFLEEFENMLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRD
SPLGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQLSKASEILK
NNTHLSITVKTNLLVFKELLTRPEHDHDTDVEDDHDRKNGAPHQPKIGDIKKASRHSIPD
LAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIL
GMKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFNNQPDMSDQVLRVFKADQQSRYIMI
GKDTTAKEVVVQAIREFALTAAPEAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGR
YYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDD
LFKRRSKTGSASLKRFEEAINHETFWVASEVTREPNQLKRMKIIKHFIKIALHCRECKNF
SSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQP
PIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR
KKKWRSLGSLSQGSANAAVLDVNQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL
SLETNEESLQTLSLQCESSISTLPKNTGGKRPDTSPVVSRAASQQRGQLAKGNQALQVPA
VALHPSRKRVPVKDLPPFGTSSPQSLKKILSLSEEGNERHRKPPEDTVSNASSQLSSPPT
SPQSSPKKGYGRMGDAYSDSGHSEISSRSSLVSNSSFDMTQEERRLRHSGGVGEFHSGGP
RMERRATTDADQYSLGSYSSMQDCRGIYAGCPTVLSSPSSEELTQDQGDRVSLDAADSGR
GSWTSCSSGSHDNIQTMQQGRSWETLLLGGGSSGGSIGGPEILGGLGGHAALWAAQTRAS
WASVSSSSSSAAYWGEDSEGDTGTIKRRGGKDVNADAETSSITSTGSEEAKLLSRPTPSP
IPSGVSSKARKDGRYREPPPTPPGYTALTISDLSEGQHPRRRPPDYTTALQRSRMVTQSP
DSHQAQQGSKHRGAGPQRTCSPAEGQEPEEEEEEGESMSAK
>Homo sapiens_RAPGEF3(ENSP_395708)
MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK
YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ
FYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD
FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML
HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL
PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV
LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL
VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT
ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV
RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE
KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA
YVQQLKVIDNQRELSRLSRELEP
>Pan troglodytes_RAPGEF3(ENSPTRP_8316)
MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK
YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ
FYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD
FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML
HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL
PNQDEPLPGSSCAIRVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV
LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL
VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMCRFNELQYWVAT
ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV
RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE
KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA
YVQQLKVIDNQRELSRLSRELEP
>Gorilla gorilla_RAPGEF3(ENSGGOP_16046)
MKVGWPGENCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK
YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ
FYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERASQGAGPSRPPTPGRNRRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLS
DFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSM
LHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVW
LPNQDEPLPGSSCAIRVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQ
VLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLD
LVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVA
TELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK
VRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINF
EKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTW
AYVQQLKVIDNQRELSRLSRELEP
>Macaca mulatta_RAPGEF3(ENSMMUP_0652)
MVLRKMHRPRSCSYQLLLEHQPPSCIQGLRWTPLTNSEESLDFSESLEQASTERVFRAGR
QLHRQLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE
GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGAHEMEEELAEAVALLSQRGPDALLTVALR
KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS
WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF
NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE
AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHQYPSSPTGMVEQERSTYICNKR
QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDARLSNLLREQWPERRRHHRLEN
GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIRVGDKVPYDICLPDHSVLTLQLPVTASV
REVMAALAQEDGWTKEQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELT
PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIYYVLGPQHLRDVTTA
NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAQGRDREMTETDFSKKLGAP
LSAVNFLSAWEAGSPVLACDRAWDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEG
NHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQ
SLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
>Mus musculus_RAPGEF3(ENSMUSP_116426)
MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVF
EHRRPSCIQGLRWTPLTNSEDSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRK
YHLRLYRHCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQ
FYRFPGPEPEPTGTQDVEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSD
FLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQEHSTYICNKRQQILRLVGRWVALYS
PMLHSDPVATSFLQKLSDLVSRDARLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAP
VWLPNQEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTK
GQVLVKVNSAGDVVGLQPDARGVATSLGLNERLFVVDPQEVHELTPHPEQLGPTLGSSEM
LDLVSAKDLAGQLTDHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYW
VATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLP
HKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDVTFIHEGNHTLVENLI
NFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQGSRISTCSEQSLSTRSPAS
TWAYVQQLKVIDNQRELSRLSRELEP
>Rattus norvegicus_RAPGEF3(ENSRNOP_61597)
MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVF
EHRRPSCIQGLRWTPLTNSEGSLDFRVSLEQATTEHVHKAGKLLYRHLLATYPTLIRDRK
YHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQ
FYRFPGPEPQPAGTHDVEEELVEAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSD
FLLTHSVFMPCTQLFAALLHHFHVEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYS
PMLRSDPVATSFLQKLSDLVSRDTRLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAP
VWFPNHEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTK
GQVLVKVNSAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHELTPHPEQLGPTLGSSEM
LDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYW
VATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLP
HKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLI
NFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQASRISTCSEQSLSTRSPAS
TWAYVQQLKVIDNQRELSRLSRELEP
>Bos taurus_RAPGEF3(ENSBTAP_8976)
MKVGWPGEGRWQVGLAVEGDSILGAPPLGGLPDVVPEGTLLNMVLRRMYRSRSCSYQLLL
EHQRPSCIQGLRWTPLTSSEESLDFSVSLEQASAERVLRAGKQLHRHLLANCPNLIRDRK
YHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWAFQDRDTQ
FYRFPGPEPEPVGVHELEEELVEALALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL
LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL
VTTLHEGDDFGQLALVNDAPRAATIILGEDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG
KVVLVLERTSQGTGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSD
FLLTHSVFMPTAQLCAALLHHFHAEPAGGSEQERSSYICNKRQQILRLVSQWVTLYGPTL
RTDPVATSFLKKLSDLVSRDTRLSNLLREQWPERRRHHRLENGCGNVSPQMKARNVPVWL
PSQDEPLPSSNCAIRVGDKVPYDICRPDHSMLTLQLPVTASVREVMAALAQEDGWTKGQV
LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELTPHPDQLGPTVGSAEGLDL
VSTKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT
ELCLCSVPGLRAQLLRKFIKLAAHLKEQKNLNSFFAIMFGLSNSAISRLAHTWERLPHKV
RKLYSALERLLDPSWNHRVYRLALTKLSPPLIPFMPLLLKDMTFIHEGNHTLVENLINFE
KMRMMARAARMLHHCRSHSNVPLSPLRSRVSHLHEDSQAVRVSTCSEQSLSTRSPASTWA
YVQQLKVIDNQRELSRLSRELEP
>Loxodonta Africana_RAPGEF3(ENSLAFP_12377)
SQVGWPGESRWHLGLAVEASPALGASPAGGLPDVVPEGTLLNMVLRRMHRPRSCSYQLLL
EHRSPSCIQGLRWTPLTDSEESLDFSVSLEQASTERVLRAGKQLHRHLLATCPNLIRDRK
YHLRLYRQCCSGRELVDGILALGLGVHSRSQAVGVCQVLLDEGALSHVKHDWTFQDRDAQ
FYRFPGLEPEPVGAHEMEEELVEAVSLLSQRGPDALLTVALRKPPGQRTDEELDLVIEEV
LIEARGHLFNSVKRELAAVLLFEPHCKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKEGL
GLEDGQLSSCDGGRPECVDHWVWLVLQDVEAKTMRLEEHGKVVLVLERTSQGAGPSCPPT
PGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPSTQLCAALLH
QYPPQPQAEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGPVLRTDPVATSFLQKLSDL
VSQDARLSNLLKEQWPERRRHHRLENGYGNASPQMKARNMAVWLAGQDEPLPNSNCAIRA
GDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDSWTKEQVLVKVNSAGDAIGLQPD
ARGVATSLGLNERLFVVNPQEVHKLTPHPEQLGPTVGSAEGLDLVSAKDLAGQLTDHDWS
LFNSIHQVELIHYVLGPQHLRTVTTANLERFMRRFNELQYWVATELCLCPVPGLRAQLLR
KFIKLAAHLKEQKNLNSFFAVMFGLSNSAVSRLAHTWERLPHKVRKLYSALERLLDPSWN
HRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCR
GHSNVPLSPLRSRVSHLHEDSQASRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSR
LSREMEP
>Xenopus tropicalis_RAPGEF3(ENSXETP_9345)
HIMDKAHRDRLAAYLFSSHFRLLQGTWHTPLPDIKSQEEYKQTVKQVVTHKVWRAAKVLH
TYLLTVSPAMMRDRKHHFRSHRQCCSGKELVDWLLGISHGLQSRSQAVGIWQVLVDEGAL
VHVRQEPNFHDKDSQFYRFVKAELHVDPLLTDKDTEEEVQESLVLLSQLGPAALLTMILR
KPPCQRTEEELEVIFEELLHIKAVSHLSNSVKKELASVLIFESHAKAGTVLFNQGDKGTS
WYIIWKGSVNVITHGKGLVATLHEGDDFGQLALVNDAPRAATIVLREDNCHFLRVDKHDF
NRILRDVEANTVRLKEHGKVVLVLEKNPQISAGNNHQPAGASNQKYTVMSGTADKILEHL
LETIKLDSCTEGIFLTDSFAGDFLLTHSIFMPTTQLCQALLHQFNVEPSEVNEPEKATYS
LHKRQNILHLVSLWVALYGKLLEAEPSAKSFLEKLSEHVSRDPRLLAFWRENLQDRRKTR
TLEVSSGNHSPQIKINSFGNLFSSLEEDASSNTYTIRAGDKVPYDIYRPDHSCITTMLPV
NASVQEVISSLATKNGYNRDQIVVKVNSSGERVCLKHEDTGVFTSLGLNERIFICYNHEL
NNVTPLPEQLGPNTSSSDILELISSKDLAHQMTDNDWNLFKSIHQVELIYHTFGKQRFRN
ATTANLERFMRRFNEVQFWVATEVCLCQEEERRALLLKKFIKLAAYLKEQKNLNSFFAVM
FGLSNTAVSRLSRTWQKLPNKFRKLYSIFERLMDPSWNHRSYRLAVAKLSAPLIPFLPLI
LKDLTFLHEGNRSTLDSLVNFEKMRMIAKTVQMFHSCRSQAYIPLSPLRPRPVNILEDPS
AARISACSEHSMTLRSPATTWAYIQHMKVIDNQKKLMELSRSLEP
>Danio rerio_RAPGEF3(ENSDARP_98662)
MEEIHARMFSFFKQILSAKKKNRLESPAVMCSADTLLRSTLRSSLQKTPLPDAVDTQDTI
KQFLSDRILKAARVVYSTLMEGNPGLIRDRKHHLKTYRQCCSGKELVDWLMKLNDCFQSR
SQAVGMWQVLVDEGILGHVKQELNFHDKDTQFYRFMEAEFDLNHTTNEKDSKDDELQESL
SLLIQMGPDALLTMILRKCPSQRTPEDLEVIYEELLHVKAVAHLSTSVRKELASVLVFES
HAKAGTVLFSQGDKGTSWYIIWRGSVNVITHGKGLVTTLHEGDDFGQLALVNDAPRAATI
ILREDNCHFLRVDKQDFIRILKDVEANTVRLEEHGKVVLVLEKSSAQDTPSCNKYTVMSG
TPEKILEHMLEAIKLETNGADFIDPCVTDFLLTHPVFMPCSQLCAALQHHYQAEPSEGSD
LEKAAYALNTKQKVVKLVCHWVALFALLLRDDPVASEFLEKFREGVMADSRLSSMLREQL
RDRRKTKIMENGCHTLTKLNQKFDWFSAYEEPVGKLRSIKAQDKVLYEIFKPDHKAVTVM
LPVDASVNDILTTLVDPDRNYVLVKMNSSGDRVQLKLETTAVSASLGVNEKLFLCTSSQV
EQLTPDKEQLGPEKSTMDTLEQICSKDMASQHTSYDWELFMAMHEVELVYYVFGREKFPG
STTANLERFVRRFNEVQYWVVTELCLCEDLGKRAILLKKFIKMAVVLKEQKNLNSFFAVM
FGLSNSAVQRLNKTWERLPNKTKRIYCAYERLMDPSRNHRAYRLTIAKLSPPYIPFMPLL
LKDMTFIHEGNKNYTDKLVNFEKMRMIARTVKTVRDCRSQPYVPSSPQKGLTERMFLDAQ
AIRISTYSDQSLNLRSATSIRQYIQNLKVIDNQKKLTQLSRALER
>Takifugu rubripes_RAPGEF3(ENSTRUP_36942)
EMHLFRSHQYQVFPDRLSVETPTIRGISWTPLPESLGSKDTMKQFLSDRVVKAARSVYSV
MIEKNPGLIRDRKYHLKTYRQCCSGKELVDWLMKQSDCLQSRSQVVGMWQVLVDEGILVH
VKQELNFHDKDTQFFRFRDSECGLNHVTNERDAEDELQEGLSLLSQLGPDALLTMILRKC
PSQRSAEDLEVIYEELLHVKAAAHLSTSVRKELAAVLVFESHAKAGTVLFSQGDKGTSWY
IIWKGSVNVITHGKGLVTTLHEGEDFGQLALLNDAPRAATIILREDNCHFLRVDKQDFIR
ILKDVEANTVRLEEHGKTVLVLEKSSDRAEQTGAGSNSKYTVMSGTPEKILEHLLETIKL
DSNGNDGIDPCVSDFLLTHKVFMSSSQLCSALLHQYPVAELSKGSDQEKASYILTAKRKV
VKLVCHWVALYDLLLKEDPVALDFLERLKKEVAADYRLSGILKEQFRERRRTRILDNGYQ
SLCRNINSTDTFLDCEEPVGRLQPIRAHDKVLYEICRADSKALTVMLPVNTTVQDVISAV
VKPGGDHVLVKMNSAGERAQLKLDAAAVYTALGVNERLFICTSSQVEKLFPLKEQQGPER
GTADILGQMGSKDIATELTNYDWELFAAMHEAELIYYVFGRHKFPGATTANLERFVRRFN
EVQHWVVTELCLCEDLVKRAVLLKKFIKIASVLKEQKNLNSFFAVMFGLSNSAVRRLYKT
WERIPSKTKRIYCSYERLMDPSRNHRAYRLTVAKLGPPYIPFMPLLLKDMTFINEGNPNY
LEKLVNFEKMRMIAKTVKVVRGCRSHPYTPSSPQRSLADRMFLDGPTTRMSTCSEHGLLL
RSPSNIRHYVQNLKVIDNQRKLTQLSRTLE
>Tetraodon nigroviridis_RAPGEF3(ENSTNIP_15500)
LGRMEMHLFRSYRYRVFPDRLSVETPTIRGISWTPLPESLDPKCSMKQFLSDRIVKAARS
VYSVMVEKNPGLIRDRKHHLKTYRQCCSGKELVDWLLKQSECLQSRSQVVGMWQVLVDEG
ILLHDKVKQELNFHDKDAQFYRFRDDGCSPNHVTNEREAEEELQEGLSLLAQLGPDALLT
MILRKCPSQRSAEDLEVIYEELLHVKAAAHLSTSVRKELAAVLLFESHAKAGTVLFSQGD
KGTSWYIIWKGSVNVITHGKGLVTTLHEGEDFGQLALLNDAPRAATIILREDNCHFLRVD
KQDFIRILKDVEANTVRLEEHGKSVLVLEKSSDTAAADRSRQQLQVRYTVMSGTPEKILE
HLLETVKLDSSGSDAVDACVSDFLLTHRVFMSSSQLCSALQLQYPDAEPSEGSDQDKASY
VLATKQRVVKLVCHWVALYGLLLKDDPVALDFLEKLKKEVGADFRLSSIVKEQFRERRRT
RILENGYQSLSRRQQNQNFDWFSHCEEPVGRLQPIRARDKVLWEISRPDGKALALMLPVD
ASVQDVISAVGKPGGDQVLVRMNSAGERAELKLDAAAVFTALGVNERLFLCSSSQVEKLF
PLKEQQGPERGTADILEQMSSKDVAAELTNYDWELFTAMHEVELIYYVFGRHKFPGAVTA
NLERFVRRFNEVQHWVATDLCLCTDLVKRALLLKKFIKIAAVLKEQKNLNSFFAVMFGLS
NSAVRRLHKTWERIPSKTKRVYCSYERLMDPSRNHRAYRLTVAKLGPPYIPLMPLLLKDM
TFINEGNANHVDKLVNFEKMRLMARTVKVVRGCRSQPYTAPSSPQRSLADRVFLEGPATR
MSTCSEHGLLRSPGNIRHYIQNLKVIDNQRQLTQLSRTLEC
>Gasterosteus aculeatus_RAPGEF3(ENSGACP_14548)
DEMHLFRSHNYRVYPDRSSVETPSIRGISWTPLPEALNSKDTMKQFLSDRVVKAARSVHS
VMIDGNPGLIRDRKHHLKTYRQCSSGKELVDWLMKQNECLQSRSQAVGMWQVLVDEGILV
HVKHELNFHDKETQFYRFQDSEFGLNHISNEKDSEEELQESLSLLSQLGPDALLTMILRK
CPSQRSAEDLEVIYEELLHVKAVAHLSTSVRKELAAVLVFESHAKAGAVLFSQGEKGTSW
YIIWKGSVNVITHGKGLVTTLHEGEDFGQLALLNDAPRSATIILREDNCHFLRVDKQDFI
RILKDVEANTVRLEEHGKTVLVLEKRTEWAQQGGAGNSKYTVMSGTPEKILEHLLETIKL
DSNGNDSIDPCVSDFLLTHKVFMSTSQLCAALQHQYPEAELSEGSEQEQASYILTTKQKV
VKLIGQWVALYGLLLKEDPVALDSLERLKKEVAGDFRLFSILKEQFRERRRTKLLFYRSE
NGYQTLSRNQPFDWFSNCEEPVGRLQPIRAKDKVLYEIYRPDNKPLTLMLPVNTSVKDVM
SAIVKPGGDHILVKMNSMGERAQLKMDANAVYTALGLNERLFICTSSQAEKLMPLKEQQG
PERGTTDLLEQMGSKDIANELTNYDWELFTAMHEVELVYYIFGLHKFPGAITANLERFVR
RFNEVQYWVVTELCICEDLVKRAILLKKFIKIAAVLKEQKNLNSFFAVMFGLSNSAVHRL
YKTWERIPSKIKRIYCAYERLMDPSRNHRAYRLAVAKLSPPYIPFMPLLLKDMTFINDGN
PNYVDKLVNFEKVRMIAKTVKIVRGCRSQPYVPSSPQRGLADRMFLEGPSTRISTYSELA
FPLRSPSSIRHYIQNLKVIDNQRKLTQLSRTIEC
>Oryzias latipes_RAPGEF3(ENSORLP_19634)
RLIEAGNLPSCGTFASFLYFFFSCKHLCVTNPSSSILTNGEHNISFEFVVSVQFLSDRVV
KAARSVYSVMNEKNPGLIRDRKHHLKTHRQCCSGKELVDWLMKQNECLQSRSQAVGMWQV
LVDEGILVHVKHELNFQDKEAQFYRFQDSDFGLSHIPNEKESEEELQEALALLSQLGPDA
LLTMILRKTPSQRTPEDIEVIYEELLHVKAAAHLSTSVRKELAAVLVFESHAKAGTVLFS
QGDKGTSWYIIWKGSVNVITHGKGIVTTLHEGEDFGQLALLNDAPRAATIILREDNCHFL
RVDKQDFIRILKDVEANTVRLEEHGKTVLVLEQSTQSARQGSAGTNSKYTVMSGTPEKIL
EHLLETIKLDSNGYDPIDPCVIDFLLTHKVFMPTSQLCPALQHQYPQMLDQAELSEGSEQ
EKDAYIIDTKQKVVKLISHWVAVYGFLLKEDPVAMDFLEEQAMKKEVAADSRLSGMLKEQ
YRERRRTKVLENGHHSLSRPLKQNQHFDWFSNCDEALGRIQPIKAKDKILYEIYRPDHKA
LTLMLPVDSPVQDVLSGVVEPGGGHVLVKMNSTGDRAELKLEASAVYTALGLNERLFICT
SSEVEHLRPLKEQQGPEQGTTDILEQIGSKDMAAELTNFDWELFTAVHEVELVYYIFGRN
KFPGAITANLERFVRHFNKLQYWVVTELCLCEDLMKRALLLKKFIKIASVLKEQKNLNSF
FAVMFGLSNSAVQRLYKTWERIPSKIKRIYCTYERLMDPSRNHRAYRLAVAKLNPPYIPF
MPLLLKDMTFIHEGNPSYVDKLVNFEKMRMLAKTVNIVRGCRSQPYVPSSPQRGLADRMF
LEGPATRLSTYSDHSLPQRSPTNIRLYIQNLKVIDNQRQLTQRSRALEC
>Homo sapiens_RAPGEF4(ENSP_380271)
MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
>Gorilla gorilla_RAPGEF4(ENSGGOP_8927)
MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFSTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVATFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
>Mus musculus_RAPGEF4(ENSMUSP_88336)
MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA
FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK
VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM
TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
>Rattus norvegicus_RAPGEF4(ENSRNOP_10630)
PNKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQ
CCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEH
EDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTADDLEIIYDELLHI
KALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCT
LHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDV
LVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFV
MMHCVFMPNTQLCPALVAQYPFPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQED
DVAMAFLEEFYVSVSDDARMMVAFKEQLAELEKTVKQISEDAKAPQKKHKVLLQQFNTGD
ERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMN
SGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKD
LAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCS
QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAE
FESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIA
NTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
>Bos taurus_RAPGEF4(ENSBTAP_53320)
MVAAHAAHSSSSAEWIACLDKKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCG
YYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILD
NTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDTFPSKEQ
TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT
ELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPL
PTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSH
LSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGD
DFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEK
VPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCV
FMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAM
AFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQ
KRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGE
KVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQ
MTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSK
RVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESL
MDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTAR
TVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
>Loxodonta Africana_RAPGEF4(ENSLAFP_8236)
MVAAHAAHSSSSTEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNVILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTQCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQSQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYTLNNKKRVIRLVLQWAATYGDLLQEDDVAMA
FLEEFYVSVSDDARMIAALKEQLPDLEKIVKQILEEAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMSSGGEK
VLLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFTDNLVNFEKMRMIANTART
VRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
>Monodelphis domestica_RAPGEF4(ENSMODP_11330)
MVAGHAAHFSSSAEGIPCRDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETSANNDRHFIFQTP
LIEPHVPLRPAKTITQVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTEL
VDWMIQQTPCVHSRAQAVGMWQVLLEEGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPT
EEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELIHIKALSHLS
TTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDF
GKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVP
AGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETVRLEQPLNEVTDSVLNDFIMMHCVFM
PNSQLCPALVAQYPFIPSQGTEQDKMDYALNNKRRVIRLVLQWAALYGDLLQEDEVAMAF
LEEFYVSVSDDSRMIAALKDQLPELEKMVKQISEDAKAPQKKHKVLLQQFNPVEDRAQKR
QPVRGSDEILFKVYCLDHTYTTIRVPVSASVKEVISAIADKLGSGEGMIIVKMSSGGEKV
VLKPNDVSVFTTLTVNGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMT
IYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCAQLSKRV
QLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKIYAEFESLMD
PSRNHRAYRLTVTKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTVRTV
RYCRSQTFNPDAALANKNHQDVRGYVRQLNVIDNQRTLSQMSHRLEPRR
>Gallus gallus_RAPGEF4(ENSGALP_10246)
GRGEPPPPPAGCAATSSLSNMVAAHTSHSASSGEWIACLDKRPLERSSEDVDIIFTRLKE
VKAFEKFHPNLLQQICLCGYYENLEKGITLFRQGDIGSNWYAVLTGSLDVKVSDTSNHQD
AVTICTLGIGTAFGESILDNTPRHATIVTREYSELLRIEQKDFKALWEKYRQYMSGLLTP
PYGVMETGSNNDRMPDKKNTPLIDSHIPHRPSKTITQVPSEKILRAGKILRNTILSRAPH
MIRDRKYHLKTYRQCCVGTELVDWMMQQSTCVHSRSQAVGMWQVLLEEGVLNHVDQEHHF
QDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQIGPDAHMRMILRKPPGQRS
IDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHPKAGTVLFNQGEEGTSWYIILKG
SVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDV
EANTVRLKEHDQDVLVLEKIPAGNRVSNQGSSQPQHKYIVMSGTPEKILEHFLETMRLEA
TLNEATDSVLNDFIMMHCVFMPNSQLCPALMAHHGTYHAQPSQGTEQEKMDYALNNKRRV
IRLVLQWAALYGDLLQEDEAAMAFLEEFYVSVSDDTRMIAALKEQLPELEKIVKQVAEEP
KAPQKKHKVLLQLFNTSDDRAQKRQPIRGSDEVLFKVYCIDQTYTTIRVPVSSSVKEVIS
AVADKLGSGEGLIIVKMSSGGEKVVLKPHDVSVFTTLSVNGRLFACPRDQFDSLAPLPEQ
EGPSAGTVGTFELMSSKDLAHQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFL
RRFNEIQFWVVTEICLCSQLSKRVQLLKKYIKIAAHCKEYKNLNSFFAIIMGLSNVAVSR
LSLTWEKLPSKFKKIYAEFESLMDPSRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTHEG
NKTLTDNLVNFEKMRMIANTVRTVKFCRSQSFNPDAALANKNHQDVRSYVRQLNVIDNQR
TLSQMSHRLEPRRA
>Xenopus tropicalis_RAPGEF4(ENSXETP_16383)
PIMVAAHTAHSTSSAEWIACLDKRPLERSGEDVDIIFARLKEVKAFERFHPNLLQQICFC
GYYENLEKGITLYRQGDIGTSWYAVLTGSLDVKVSETNNHQDAVVICTLGVGTAFGESIL
DNTPRHATIVTRENSELLRIEQKDFKTLWEKYRQYMAGFLAPPYGVLETGSNDSKLSDKE
NTPLIENQIPIRPAKTITEVPSERILRAGKTLRNAILTRAPHMIRDRKYHLKTYRQCCVG
TELVDWLMQQSSCVHSRTQAVGMWQVLLEDGVLNHVDQEYYFQDKYLFYRFLDDEHEDAP
MPTEEEKKESDEELQDTLLLLSQIGPDAHMRMILRKPPGQRSADDLEIIFEELIHIKALS
HLSTTVSPFLELHCILKKKVFQSRRSTKIIIFNQGEEGTSWYIILKGSVNVVIYGKGVVC
TLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQD
VLVLEKILAGSQGSAQGNTQSPYKYTVMSGNPEKLLEHFLETMRLDPSLNDATADTALDD
FILMHCVFMPNSQLCPALMSQYHAQPSQGTEQEKLDYTLNNKRRVIRLVQQWATLYGDLL
REDEVSMAFLEHFHKGTNAKIESKKLVAALSRDLQKIKRLIMNISEDAKGQQKKHKVLLR
QFSTGDERLQKRQAIRSSDELLFKVYCIDHTYTTIRVAVAASVKEVLSAVADKLGSGDSL
ILVKISSAGEKVVLKPNEISVFTTLSVNGRLFACPRDQFDSLTPLPEQEGPSAGTMSTFE
LMSSKDLAYQMTIHDWDLFSCVHELELIYHTFGRQNFKKTTANLDLFLRRFNEIQFWVVT
EICLCPQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLSLTWEKLPSKF
KKIYAEFENLMDPSRNHRAYRLTVAKLDPPIIPFTPLLIKDMTFTHEGNKTFIDNLVNFE
KMRMIANTLRTIRYCRSVPFNPDASLAGKNHQDVRNYVRQFNVIDNQRTLSQMSHRLEPR
RA
>Danio rerio_RAPGEF4(ENSDARP_114027)
MISPKMVAAHTSSHPSASADWIVCLDKRPEERSGEDVDIIMVRLKSVKAFEKFHPPLLQQ
ICLCGFYECLEKGITLYRQGDIGTNWYTVLSGSLDVKVSETANHQDAVTICTLGIGTAFG
ESILDNTPRHATIVTREFSELLRIEQKDFRNLWENYRQCMAGLLVPPYGVMDSGPNADRM
PDKENLSNSSPGLSPKHLNKVPSEKILRAGKVLRNIILSRAPHMIRDRKYHLKTYRRSCI
GTELVDWLLQHTSCVHSRVQAVGMWQVLLEEGVLNHVDQEPTFQDKYLFYRFLDDESEDS
GMPSEEDKKESDEELQDTLLLLSQIGPDAHLRMILRKQPGQRTVDDLEIIYEELLHIKAL
SHLSTTVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE
GDDFGKLALVNDAPRAASIVLREDFCHFLRVDKEDFNRILRDVEANTVRLKEHEEDVLVL
EKANNRSSSSSPLKYTVMSGTPEKILEHLLETMKLDCQFSESDPALDDFLLMHCVFVPNS
QLCPLLMTQYPSLIKPYCFSTKTPHQASQGSEQERMDYTLNNKRRVVRLVLQWASINTDH
LQEEDSSFSFIQEFYEMVCEDSRLTPALKDHLPELEKIIKQNSDDGRPSQKKHKVLLRQF
STGNDRLQKRQPIKSTDENKELLKPSDVSIFSSLSINGRLFVCPRDQIDSLTPLPEQEGP
SAGSMSTFELMSSKDLAHQMTLYDWELFHCVHEHELIYHTFGRHHFKKTTANLDLFLRRF
NEVQLWVVTEVCLCPALSKRVQLLKKFIKIAAHCKEFKNLNSFFAIIMGLGNPAVCRLSQ
TWEKLPSKFKKFYGEFENLMDPSRNHRAYRLTMAKLEPPIIPFMPLLIKDMTFTHEGNKT
FTDRLVNFEKMRMIANTVRIIRYCRSQPFDQEAPQATGKSHQDVRTYVRHISVIDNQRSL
SQLSHRLEPRRT
>Takifugu rubripes_RAPGEF4(ENSTRUP_45217)
MVAAHPSSHSSESAQWIICLDKRPAERSGEDVDIILARLKKAKAFEHFHPSLLHQICLCG
FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSYHQDAVVICTLGTGTAFGESILD
NTPRRATIVTREFTELLRIEQREFRCLWERYHHCMAGLLVPSYGVMESACSADRMPNKEN
VSDNPFVSIGKHQNKVPSEDILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELV
DWQMQQSSCVRSRLQAVGMWQVLLEEGVLNHVDQELSFQDKYLFYRFLDDEQEDALFPSE
EERRESQEELQDTLLLLSKIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST
TVKRELAGVLIFESHAKAGTVLFSQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG
KLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHGQDVLVLERSLG
NSRSSIHGASSSQYKYTIMSGTPEKILEHLLEMMRLDSQFTESADSALDDFVLTHPVFIP
NSQLCPVLMAHYHAQASQGCEQERMDYTLNNKRRVIRLVMRWAAVHGDHLLEEEDVVAFL
QEFLVAVSNDAKVLPALREQLAKLEITVKHYTEDARISRKKHKVFLRQFSTGEEKLQKRQ
PIKSNDEILFKVYCCDNTYTTIRAPVAASVRELISSLAEKLGSTEDLLLVSLGSAGEKVI
FKPNDVSVFSTLSINGRLFVCRRDELDSLTPLPEQVEPSAGLSSNFELMSSKDVACHMTS
YDWELFNCVHELELIYHTFGRQNIQKTTVNLDLFLRRFNEIQFWVITEMCLCSQLSKRVQ
LLKKFIKIAAHCKEYKNLNGFFAITMGLSNPAVCRLNMTWEKLPSKFRKFYREFENLMDP
SRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTQEGNKTFIDTLVNFEKMRMIANTVKILR
YCRSQPFSPDSPQAGKSHSDVRAYVRQFNVIDNQRTLSQLSHSLEPPRS
>Tetraodon nigroviridis_RAPGEF4(ENSTNIP_20064)
MVVAHASSHPSESAEWIICLDKRPAERSGEDVDIILARLRRVKALERFHPSVLQQICRCG
FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSYHQDAVVICTLGTGTAFGESILD
NTPRHATIVTRECTELLRIEQRAFRSLWERYHHCMAGLLVPPYGVMESACSADRMPNTEN
ISDDAFVSADKHQNKVPSENVLRAGKILRNAILSGAPHMIRDRKYHLKTYRRCCVGTELV
DWQMQQSSCVRSRVQAVGMWQVLLEEGVLSQVDQELSFQDKYLFYRFLDDEQEDAPFPSE
EEERESQEELQDALLLLSQIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST
TVKRQLAGVLIFESHTKAGTVLFSQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG
KLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHGQDVLVLERSLG
NSRTSVHGASSSQYKYTIMSGTPEKILEHLLEMMRLDSQFTESADSALDDFLLTHPVFIP
NSQLCPVLMAHYHAQASQGCEQERMDYTLNNKRRVIRLVMQWAALHGDHLQDEEDSVVFL
QEFLVAVSNDAKVLPALRDQLAKLETTVKHYAEDARVSQKKHKVFLRQFSTGEEKLQKRQ
PIRSNDEILFKVYCCDNTYTTIRASVAASVRELMGALAEKLGSAEDLLLVSLGSAGEKVI
FKPNDVSVFSTLGINGRLFVCRRDELDSLSPLPEQVEPSAGLSSNFELMSSKDVACHMTS
YDWELFSCVHEFELIYHTFGRQNFRKTTVNLDLFLRRFNEIQFWVITEMCLCSPLSKRVQ
LLKKFIKIAAHCKDYRNLNGFFAVTMGLSNPAVGRLSLTWEKLPSKFRKFYREFENLMDP
SRNHRAYRLTAAKLDPPIIPFMPLLIKDMTFAHEGNKTFVDNLVNFEKMRMIANTVKILR
HCRSQAFSPDSPPAGKNHSDVRAYVRQFNVIDNQRTLTQLSHGLEPPRP
>Gasterosteus aculeatus_RAPGEF4(ENSGACP_6371)
MVAARTSSHSSESVEWIICLDKRPAERSGEDVDIILARLKNVKAFERFPPILLQQICLCG
FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSSYQDAVTICTLGAGTAFGESILD
NTPRHATIVTREFSELLRIEQREFRSLWEKYHQCMAGLLAPPYGVMESGCSGDTMPDKEN
ISNNSFVSVSKHQNKVPSEKILRAGRILRNAILSGAPHMIRDRKYHLKTYRRCCVGTELV
DWQIQQSSCIHSRVQAVGLWQVLLEEGVLNHVDQELSFQDKYLFYRFLDDEQEDAPLPGE
AEGKESQEELQDTLLLLSQIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST
TVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG
KLALVNDAPRAASIVLREDNCHFLTVDKEDFNRILRDVEANTVRLKEHGQDVLVLEKSLG
SSRASTHGASSSHYKYKVISGTPEKILEHLLEMMRLDSQFTESADSALDDFVLTHCVFIP
NGQLCPVLMAHYHAEALQGSEQEKRDYTLNNKRRVIRLVMQWAAVHRDHLQEEDTSVAFL
EEFVTAVSNDVKALPALGDQLTELERSLKRNTDDARVSKKKHKVLLRQFSMGDEKLQKRQ
PIKSNDEILLKVYCCDHTYTTIRVPVGASVREVVGAVADKLGSAEDLLLVGLSSAGEKVI
FKPNDVSVFSTLSINARLFACRRDQLDSLTPLPEQEGSSTGPLASFELMSSKDVAYHMTS
YDWELFHCVHELELLYHTFGRQNLKKTTVNLDLFLRRFNEIQFWVITEMCLCSQLSKRVQ
LLKKFIKIAAQSCKEYRNLNAFFAVIMGLSNPAVCRLSQTWEKLPSKFKRFYGEFENLMD
PSRNHRAYRLTVAKLEPPIIPFMPLLIKADMTFTHEGNRTFIDYLVNFEKMRMIANTLKI
VRYCRSQAFSPDSTQASKNQAEVRTYVRQFKVIDNQRTLSQLSHRLEPRRS
>Oryzias latipes_RAPGEF4(ENSORLP_21824)
MVAARTSAHSSQTADWINSLDKRPEERSSEDVDIILARLKKVKAFKGFNPSLLQQICLCG
FYEGLEKGIMLYRQGDIGTSWYTVLSGSLDVKVSETSSYQDGVTICTLGTGTAFGESILD
NTPRHATIVTREFSELLRIEQKEFRSLWEKFYYCMAGLLVPPYGVMESTCGSDRIPDKEN
IPFVPLSKHPNKVGNSIFPTLSEKILHAGKILRNAILSKAPHMIRDRKFHLKTYRQCCVG
TELVDWLMQQSSCVHSRPQAVGMWQVLLEEGVLNHVEQEMNFQDKYLFYRFLEDEREDAP
LPSEEEKGESQEELQEALLFLSQTGPDAHLRMILRKPSSDRAADDLEIIYEELLNIKALS
HLSTTVKRELAGVLIFESHAKAGTVLFNQGDEGTSWYIILKGSVDVVIYGKGVVCTLHEG
DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLEEHGQDVLVLE
KTLGSARNSADGSSAVHYKYRVMSGTPEKILEHLLKMMRLDLQFTESVTDSALDDFVLMH
CVFVPNSQLCPLLRAHYHAQASQGSEQEKLDYALNNKRRVICMIMKWATVHDDQLQQEDV
AFLQESLISASNDATWLPALGDQLTELERVVKRCAEAAMASQKKHKVFLRQFSLGEEKPQ
KRQPIRGSDEILFKVYCCDHTYTTIRVPVAASVQEVISAVADKLGSVEELNLVHLSSAGE
KTIFKPNDVSVFSTLSVNGRLFACRRDQLDSLTPLSEQGGPSSGSLSSFELMSSKDVAYH
LTSYDWELFHCVHELELIYHTFGRQHINKTSVNLDLFLRRFNEIQFWVITEICLCSQISK
RVQLLKKFIKIAAHCKDYKNLNAFFAIIMGLSNPAVSRLSQTWEKLPSKFKKFYGEFENL
MDPSRNHRSYRLIFSKLEPPVIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIAKTVK
IVRYCRSQTFSEDAPLPSKHHPDVWTYVRQFNVIDNQRILTQLSHGLEPRRS
>Homo sapiens_RAPGEF5(ENSP_343656)
MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQ
LVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEEN
NDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQ
DDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHL
EEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHL
VSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDE
YSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILK
VVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAE
NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL
QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR
LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG
NKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALF
ELSHRIEPRV
>Pan troglodytes_RAPGEF5(ENSPTRP_56753)
MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQ
LVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEEN
NDKRVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQ
DDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHL
EEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHL
VSQWIALYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDE
YSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILK
VVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAE
NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL
QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR
LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG
NKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALF
ELSHRIEPRV
>Gorilla gorilla_RAPGEF5(ENSGGOP_20894)
LLEADCDTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYR
RSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDE
CSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAV
QRELAAVIALKARKSAIEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQ
KLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESH
WRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRMGR
HSICTYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKTIYRNVL
DDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET
EEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGDKEKHELQ
PNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDW
SLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVK
KFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLN
HKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCR
TNQFGSDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV
>Mus musculus_RAPGEF5(ENSMUSP_105313)
MTTGDCQTLSRRISNPYLEHSPSQIYGENSSCAGRALRNIIILQAADLVKDRVNLKGFYR
RSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMSSVDQHLYFQDNYVFYQFSSDE
CSYLYCEFEREEEWQKGVKLLLELVHLIPARAGICDLSHQKTEDSEESSDEILARLTSAV
QRELAAVIALKARKSAIEQDDENADKHVTVTEANNGPDPQAGVMCKLQERDDIGRIELVH
KLARENCQFLQTEKKESEKLEQQDDEVTMVQVKEQGQSVLVLKKVASCGPAPTSGSAEND
ARYVVVSGTPEKILEHLLNDLHLAEVQHKETETLLDDFLLTYTVFMTTDDLCQALLRHYS
AKKYQGEEENSDVPCRKRKVLHLVSQWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYP
ILEKELKEFQKILGVYRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHV
YITEHSYISVKAKVSSTAQEILKVVAEKLQRAEEDLALVAITFSGEKHEFQPNDLAISKS
LEASGRIYVYRKDLADTLNPLAENEESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQ
ELIYFTFSRQGNGENTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHC
KAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFK
KMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDVS
PKEQQELKSYVNHLYVIDSQQALFELSHRLEPRA
>Rattus norvegicus_RAPGEF5(ENSRNOP_7112)
TLSRRISNPYLDHSPSQIYGENSSCAGRALRNIIILQAADLVKDRVNLKGFYRRSCVGSE
LVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMSSVDQHLYFQDNYVFYQFSSDECSYLYCE
FEREEEWQKGVKLLLELVHLIPARAGICDLSHQKAEDSEESSDEILARLTSAVQRELAAV
IALKARKSAIEQDDENTDKHVTVTEANDDAPDPQAGVMCKLQERDDIGRIELVHKLAREN
CQFLQTDKKEPEKSEQQDDEVTMVQVKDQGQSVLVLKKVASCGPAPTTGSAESDARYVVV
SGTPEKILEHLLNDLHLAEVQHKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQG
EEENSDVPCRKRKVLHLVSQWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKEL
KEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYVTEHS
YISVKAKVSSTAQEILKVVAEKLQRAEEDLALVAIMFSGEKHEFQPNDLAISKSLEASGR
IYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFT
FSRQGSGEHTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQQNL
NSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPK
IPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDMSPKEQQE
LKSYVNHLYVIDSQQALFELSHRLEPRA
>Bos taurus_RAPGEF5(ENSBTAP_33741)
WGSGPCQTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRANLKGFYR
RSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGILSSVDQHLYFQDTYVFYQFSSEE
CSYLYCEFEREEEWQNGVRLLLQLVPLIPSRAGICELSHQKIEDSEESSDEILARLTSAV
QRELAAVIALKARKSALAQDEENSDKHVTVTEAEAAADPQAGMMCKLQERDDIGRIELVQ
KLARESCQFLQTDKKEQEKSEHQLKQDDEVTTVEVKEQDQNVLVLKKVQSCGPAPQAGSA
ESDWRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLR
IYSAKKYQGKEENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKTIYRNVLDDVY
EYPILEKELKEFQKILGMHRRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTESEEIF
CHVYITEHSYVSVKATVSSTAQEILRVVAEKIQHAEDDLALVAVTFSGDKEKHELQPNNL
AISKSLDASGRIYVYRKDLADTLNPFAENEESQQRSIRILGMNTWDLALELMNFDWSLFS
SIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSPLGKRVQLVKKFIK
IAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAY
RDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQF
GGDISPKEHPELKSYVHHLYVIDSQQALFELSHRIEPRV
>Loxodonta Africana_RAPGEF5(ENSLAFP_12495)
TLSRRISNPYLDHTPSQIYGESSSCAGKALRNIIIVQAADLIKDRVNLKGFYRRSCVGSE
LVDWLLEHCPFVQCRSMAVGVWQLLLDMGIMLSVDRHLHFQDTYVFYQFSSDECSCLYCE
FEREEEWQNGVKLLLHLVPLIPARSGICELSHQKIEDAEETSDEILARLTSAVQRELAAV
IALKARKSAIEQDEENSDKHIAVPEAEGVPQSQAGVMCKLQERDDIGRIELVQKLARENC
QLLQTDKKELEKSEHQDDEVTTVQVKEQDQNVLVLKKVPGGGPAPTSGSTENDWRYVVVS
GTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGK
EENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELK
EFQKILGMHRRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSY
VSVKAKVSTTAQEVLKIVAEKIQHAEEDLALVAVTFSGDKHELQPNDFAISKSLEASSRI
YVYRKDLADTLNPFAESEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTF
SRQGSGEHTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLN
SFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKI
PFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGGDVSPKEHQEL
KSYVNHLYVIDSQQALFELSHRIEPRA
>Monodelphis domestica_RAPGEF5(ENSMODP_1532)
LPTFDVPYFKYIDEEDEEDEWSNRSQSSTEDESSDSLLSDRYVVVSGTPEKILEHLLNDL
HLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALPPQHWPHGPAHLFSLTLRTYSAKKYH
GREETCDIPRRKRKVLHLVSQWIGLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPVLEKE
LKELQKMLGLHRRHTVDEYSPHRKNKALFHQFSLKENWLQHRGTVGETEEIVVCHVSLVN
DSDPNMYVSVRDAAMSTGFLPVSRLCSHSVSFDFLKEKHELQPNDLAISKSLELSGRIYV
YRKDLSETLSPLVESEESQQRSLRILGMNTWDLAMELMNFDWSLFNSIHEQELIYFTFSR
PGSSENTVNLSLLLQRCNEVQLWVATEILLCSQLCKRVQLVKKFIKIAAHCKAQRNLNSF
FAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPF
MPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRSLRHCRNSHFGGDVSPKEHQELRS
YVHHLHVIDNQQVLFELSHRIEPRA
>Gallus gallus_RAPGEF5(ENSGALP_17724)
QTVLQTLSRRISNPYLETPSNKIYGESSSCAGRALRNIFTLQASDLIKDRVYLTGICRRS
CVGSELVDWLLEHCPFVKCRSTAVGVWQLLLDMGIILSVDRELYFRDTYTFYQFSADECT
YLFCEFEKEGGWKNAVKLLLQLLPLSPPRIDVCNLPDQKIEDTAETNAEILARLTSAVQR
ELAAVIALKARKSAIHQNEENSSQEIRGLEELKTASDAQAGVLCKLQERDDIGRIELVQK
LARENCQFLQADRKQPEKTDQNKEEEVTLCQVARESKKEIPRKNIARCKQAAPTRGCETE
DCRYVVVSGTPEKILEHLLSDLHLEAAQDKETETLLDDFLLTYTVFMTTDDLCQALLSTY
CAKNHQGKEDDSDVSCRKRKVLHLVSQWTSLYKDWLHEDEHLKQFLKTIYRNVLDDVYEY
PILEKELKEFQKILGMHRRHTVDEYSPHRKNKTFFHQFSLKENWLQHRGTMNEAEEIFCR
VYITEHSYVSVKAQVTTSAQEIVKIVAEKIQYPEEELALVIITFSGEKHELQPNDLAISK
SYESSSRMFVYRRDLTDSLNPFAENEELQQRSVRILGINTWDLALELTTFDWSLFNAIHE
QELIYFTFSRQGSAENTENLSLLLQRCNEVQLWVATEILLCSQLCKRVQLVKKFIKIAAH
CKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFTELESLTDPSLNHKAYRDAF
KKMKSPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRSLRHCRNNQFGNEV
PSKEHHELKPYIHHLHVIDNQQALFELSHRIEPRA
>Xenopus tropicalis_RAPGEF5(ENSXETP_16124)
MHFFQCFSLSTKRIPSLYVDNSATKLYGESVSCAGRALRNAVRSQTPELIRDRMYLTCIC
RKSCVGSELVDWLLQHCPFVQCRYTAASIWQILLKLGILLSVDKQLCFQDTYVFYQFSSE
ECGDAGCEFGRDKGWLMGVRLLKQLAPLVPLTSNMCDVSADKLDHSNEANNKVLQIQALA
RLTSAVQRELAAVIALKARKSAIGQNSWTGSKQSTCQESQVPPLPQAGVMCKLHGREEFR
RIDFVQKLKRETNCICLRSSNNEADYIWKQDEEESTVQVKEEDQDVLVLKKVLSESPAPT
AGSAENDWRYMVVSGTPEKILEHLLNDLHLDEVQDKDTDTLLDDFLLTYTVFMTTDDLCK
ALLRQYPSETKYEGKAESPEALCTKRKVLLLASQWTALYKDWLHEDEHSKLFLKTLYRYV
LDDVYEYPILEKELKEFQKVLRIHRRHTVDEYSPHRKNKALFHQFSLKENWLQHRGNANE
IEEIFCRVYITDHSYVSIRAKVSSSAQDILKTVAERIQLSEEDLALVTVTYCGEKQELLP
NELVLSKSLEPSSRIYTYRKSDTLNPFAENEETQHRSVRLLGINTWDIAFELTSFDWSLF
NSIHEQELIYFTFSRQGKGENTLNLSLLLQRCNEVQLWVATEILLCNQPGKRVQLLKKFI
KIAAHCKAQRNLNSFFAIIMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKA
YRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADAVRSVRYCRNNQ
FGNDLPQKERQEAKFYSNHLHVIDNQQTLFELSHRIEPRV
>Danio rerio_RAPGEF5a(ENSDARP_100132)
MELVNESPSFKDLVCKVLEVHKSRTDPPRLLKNGSQFKKNLEVIISQKPPPDSILCSNAG
QTRHQACVNNVPCAGQALRNAVLSNCQDNWKTHVKLAKIIRRTYIGIELVEWLMDHCEFI
QNREIASKIWNVLLDLGILLSVEQNNIFEDSRSLYQFTFKECEAQSCDFRNQVNWRSAVH
LLLQLVPHEQLCGGTQRRCKEDKQKTPDACNPVLQMRALEHFTSTVQNELLAALARKAQT
KSMEEDSNPQHNTDTPGSSSTPAVLKQVPGAGTRDREEISRLEMVQRLAKDGCRLLHSPL
RVNERPAEPLGDAAVRVCERSHEVLLPKRTTSLKSPSSSSSSWSRRYAAVPASPEKVLEH
VLGQLRLDEEQKSLQSRETDSLLDDFLLTYPVFMSTSDLCQALLGHYCSKKGRMKEEWRE
SLLRKRKVLHLLSQWSSLCTELPQDDDNTKLFLKTLYRHVLDDLYEFPPLEKDLKELQKL
LRMQRRHTVDEYSPQRKNKALFHQLSLKESWHPMRGPERERKEVLCRVYVTVDSYVSVRT
HSEVCVQELLRAVAERLDCAEDDMVLMALTYPGEKVVLELDQCVFSSSLSAAERLHVFRR
DLTEIMSPFTDNGQQCSGKMLSMNTWDVSVSLTNCDWSLFSNIHEQELVYFTLSRDSSSG
HTVALEQLLQRCNETQQWVMTEVLLCSTLCKRVQLFKKFIKIAAHCKAQRNLNSLFAIIL
GLNSPAVSRLTQTWEKVPGKFRKLFSELESLTDPSLNHKAYRDAFRKMKSPKIPFLPLLL
KDITFIHEGNKTFLDNLVNFDKLHMIADTVRIIRQCRTDHMGNLLFQKDSMEVRTYINYL
HLIDNQQTLFELSHRLEPKT
>Danio rerio_RAPGEF5b(ENSDARP_103378)
MKTLYRYVLEDVYEFPTLEKDLKEFQKLLRRRHTVDDYSPHQKNKALYQQLSLKENSVSL
RASPVESRDVMCRVYVSCDSYLSMRVKPAVVAQELLHIVSQRMDRCEDDMMLLAQTYSGE
KRVLQPHDSIYSESLVAPGRLIACRRDLSEILPPLTECPDLGQKPVRLLGINTWDVAVAL
TNFDWNLFNSIHEQELIFYTFSRQASSGHTVALEFLLQRCNEVQQWVMSEVLLCPSLSKR
VQLLKKFIKIAAHCKAQRNLNSSFAIIMGLNTAAVSRLNQTWEKVPGKFKKLFSELELLT
DPSMNHKAYRDAFKKMKPPKIPFMPLLLKDITFIHEGNKTFHDNLVNFEKLHMIADTVRL
IRHCQMDQTGNELSAVDSAEVRSSVHYLHIIDNQQTLFELSHRLEPRV
>Takifugu rubripes_RAPGEF5a(ENSTRUP_40407)
MCILHDKEDLSRLEMVQRLAKDGCRFLQNHSKGPERPSEKSDEVIRVCLRERGHSVLVLQ
RMSSEQPTPAASSGAEREEARDRRFVVVSGTPEKILEHLLDDLTLEEDQGTTHGNESDTL
LDDFLLTYPVFMSTGDLCQALLGQYPYKRKVKEDGREALERKRKVLFLVSQWMELCNDFL
RDDERVKHFMKTLCSYVLDDLYEHPALEKDVRELQRLYMLHRRHTTDEYSPQRKSKALFH
QLSLRDNGLQSRGLLRENKEALCHVYITMDSFLSMRVHAGVTAQELLQAVEERMDVPQGD
LLLVAVTYPGGRLLLQPQDRIFSDCLRPIGRLHVCKKDLGEILNPFTDNSELHQRTARML
TLNTWDVAVALTQLDWAIFHSVHEQDLVYFTFSRHSSSSSSSSSSRTVGLELLLQRCNEV
QLWVMTEVLLCPLLCKRVRLIKKFIKIAAHCKAQKNLNCFFAIIMGLNTAAISRLSQTWE
KIPGKFKKLFSELEAITDPSLNHKAYRDSFKKMKAPKIPFLPLLLKDITFIHEGNKTFHD
NLVNFEKLHMIADAVRFLRQCQRDHMGNGIIQKSSSEARAHIDYLHVIDNQQTLFELSHR
LEPRT
>Takifugu rubripes_RAPGEF5b(ENSTRUP_21305)
CAGRSVRNAFLSHGPYPAKDKIHLARIIRRSYVGVELVQWLCEQCVYVRCRTTAVRVWQV
LLELGVLLSVDQRVIFSDSNTYYQFSFEECDSPSCEFRSNEGEWPEAVRLLLQLAPYVQF
RSGGGANSPSQSHDSTLTGIATRAKLVCIVQSELAAALARKTRKALSEQDSETMELSGVC
TLRGGGGGGGGGIGTCNREELTSRLGLETVQRLAKDGCRLLQNHNHRLSDKNQADEALGR
VCLKERGRDVLVLQRVKSSVTSPSDRPSPTSSGGGSREDDCDKRYVVVSGTPLKILEHLL
SDLRLDDQRGAPESRESEMLLDDFLLTYLVFMTTHDLCQALLGTYSSTRCRGQEEGKDAL
FRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKTLYRCVLEDLCEFPTLEKDLKEFQKLLR
RRHTVDDCPPNQKGKQMYQQLSLKENCVSLRSPAADTREVICCVYVSADSYLSVHTHPSL
EAHELLRIVSLKLDRAEEEMVLAVMSNTGERRLLQPSDCVYSESLTPQGKLVACRRDVTE
ILPPLSDSTELSRRPVRLLGINTWDVAAALTHLDWTLFKSIHEQELAYYTLSHPPGAGHT
AALSVLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIAAHCKAQRNLNSAFAIIMGL
NTAAVSRLNQTWEKCPGKFKKLFSELELITDPSLNHKAYREAFKKMKPPKIPFMPLLLKD
ITFIHEGNKTFHDNLVNFEKLLNPQHMIADAVRMIRHCQSDQPGNEVIGVDSAEVRGSVQ
YLHIIDNQQTLFELSHKLEPRA
>Tetraodon nigroviridis_RAPGEF5(ENSTNIP_2394)
MCILHDKEDLSRLEMVQRLAKDGCRFLQNHSKGPERPSEQSDEAVLVCLRERGHSVLVLQ
RMSSEQPTPSASSRAEREEARDRRYVVVSGTPEKILEHLLNELTLEEDQPKEAETLLDDF
LLTYPVFMSTSDLCQALLDSTYCTKRCRGKEDGREALERKRKVLYLVSQWMELCNDFLRD
DERIKHFMKTLCSYVLDDLFEHPSLEKDVGELQKLYMLHRRHTTDEYSPQRKSKALFHQL
SLRDNGLQSRGVLRESKEALCHVYVTINSFLSVRVHAGVMAQELLQAVAERMDVPQGELL
LVAVTYPGGRLLLQPQDRILSDCLRPIGRLHVCRKDLGEILNPFTDNSELQQTAARMLTL
NTWDVALALTNLDWAIFHSVHEQELVYFTFGRHSSSSSRTVALELLLQRCNEVQLWVMTE
VLLCPLLCKRVQLIKKFIKIAAHCKAQRNLNCFFAIILGLNTAAVSRLSQTWEKIPGKFK
KLFSELEAITDPSLNHKAYRESFKKMKAPKIPFLPLLLKDITFIHEGNKTFHDNLVNFEK
LHMIADAMRFLRQCQRDHMGNDISQKSSSEARAYIDYLHVIDNQQTLFELSHRLEPRA
>Gasterosteus aculeatus_RAPGEF5a(ENSGACP_10631)
TSASRLPHSSSADSSSDSTSRAEPVTMPTFDVPYFRYIDDEGTEGDEGWSSSRSMSSIEE
DSSTDSVVSDRYMVVSGTPEKILEYLLDDLTLDDDQGTTPTKESDILVDDFLLTYPVFMS
TGDLCQALLGQYPCKRYRGKEDRKEALERKRKVLHLVSQWMSLCRGFLREDEHVKLFTKT
LYRYVLDDLYEHPFLEKDVRELQKLYQLHRRQAVDEYSPQRKGKALFHQLSLKENSLQSR
GTQGETKAALCHVYVTMDSFLSMRAHAGMVAEELLQAVAERMEVPLEKLVLLAVTYNGGR
HLLQPQDRVFSDSLRPVGRLHVCRKDLGEVLNPFTDNSELQQRTARMLSINTWDVAVALT
DFDWTIFESIHEQELVYFTFSRHSSSSHTVALELLLQRCNEVQLWVMTEVLLCSALCKRV
QLIKKFIKIAAHCKAQRNLNCFFAIIMGLNTAAVSRLGQTWEKIPGKFKRLFAELETITD
PSLNHKAYRDSFKKMKAPKIPFPPLLLKDITFIHEGNKTFHDNMVNFEKLHMIADTLRLI
RQCQKDHMGNGITQKSSSEVRAYIDYLHIIDNQQTLFELSHGLEPRA
>Gasterosteus aculeatus_RASGEF5b(ENSGACP_8098)
RRSYVGVELVQWLCEQCVYVRCRTTGVRVWQVLLELGVLLSVDQRVMFSDSNSYYQFSFE
ECDSASCDFRSNEGEWPEAVRLLLQLAPYIQFRSGGGANSPHPRSEEDSEGNRDICSEML
QIQQVQNELAAALARKTRKALSEQDSESTDTSQQEPQTPSEESSPGTGTVCGREELTGRL
GLEAVQRLAKDGCRLLQNHNYRVPDRTQADNEAVGRVCLKERGRDVLVLRRVTSSVTSPS
DRPSPTSSGGGSREEDCDKRYVVVSGTPLKILEHLLSDLRLDDQRGAPECRESETLLDDF
LLTYLVFMSTNDLCQALLGQYPSDRCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEE
EHVRSFMKTLYRCVLEDLYEFPTLEKDLKEFQKLLRRRHTVDDCPPNQKSKQMYQQLSLK
ENCLQLRSPPSETKEVICCVHVSADSYLSVHTHHSLEGHELLRIVGQKMDRAEEDMVLAV
ASHTGERRVLQPSDCVYSESMTPQGKLVACRRDLTEILPPLTDSAELSRRPVRLLGINTC
DVAAALTHLDWSLFKSIHEQELAYYTLSRVPGTGHTAALSVLLQRCNEVQQWVMSEVLMC
TSLNKRVQLLKKFIKIAAHCKAQRNLNSAFAIIMGLNTAAVSRLNQTWEKCPGKFKKLFS
ELELITDPSLNHKAYREAFKKMKPPKIPFMPLLLKDITFIHEGNKTFHDNLVNFEKLHMI
AETVRMIRHCQSDQPGNEVIGVDSAEVRASVHYLHIIDNQQTLFELSHKLEPRA
>Oryzias latipes_RAPGEF5a(ENSORLP_8886)
LTMPTFDVPYFRYIDDEGAEGEEEWSCSRSMSSIEEDSSADSAVSDRYVVVSGTPEKILE
HLLSDMTLDDDCGTTQGKESDKLLDDFLLTYPVFMSTSDLCQALLGQYPHKRHRGMEEPK
EALERKQKVLHLVSHWMSRCKDFLREDQHVKLFLKTLYRYVLNDLYEHPTLEKEMGELQK
LYQLHRRHTGDEDSPHRKSKALFHQLSWKENVPQSRGSQRETKEVLCHVYVTMDSYLSMR
VHSEVVVQELLQAVAERMGVSQGELLLVAITCTGGRLLLQPQERVFSASFRSVERLHVCR
KDLSEVQNPFVDNSEIQQRTARVLSLNTWDVAVALTDLDWTIFDSMHEQEVIYFTFNRHV
CSTYTMALELLLQRCNEVQLWVMTEVLLCPTLCKRVQLIKKFIKIASHCKAQRNLNCFFA
IFMGLNAAAVSRLSHTWEKVPGKFKKLFSELEAITDPSLNHKAYRESLKKMKVPKIPFLP
LLLKVDITFIHEGNRTFHNNMVNFEKLHMIADMVRLIRQCQKDRMGNGITQKSSSEVRAY
IDCLHVIDNQQTLFELSHRLEPRA
>Oryzias latipes_RAPGEF5b(ENSORLP_4879)
TSMLATLAEAEEDEDEADSEDEDGTNSDTFDVPHLRYIDDDSKEEEKEGSWVDTDCWNSS
SYRYVVVSGTPLKILEHLLSDLRLDDQRGAQENRESEMLLDDFLLTYLVFMSTHDLCQAL
LVTYGGARCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKTLYRCVLED
LYEFPSLEKDLKEFQKLLRRRHTVDDCPPNQKSKQMHQQLSLKENYLHLRTPQTEHKEVM
CCVYVSADSYLSVHTHPSLEAHELLRIVGMKMDRAEEDMVLAVVSHTGERRVLQPSDCVY
SESLTPNGKLVACRRDLNEVLPPLADSAELNKRPVRLLGINTWDVATALTHLDWTLFKSI
HEQELVYYTLSRPPGSGHTAALSLLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIA
AHCKAQRNLNSAFAIIMGLNTAAVSRLNQTWEKCPGKFKKLFSELELITDPSLNHKAYRE
AFKRMKPPKIPFMPLLLKDITFIHEGNKTFHDNLVNFEKLHMIADTVRNIRHCQSDQAGN
EVIGVDSADVRASVHCLHIIDNQQTLFKLSHKLEPRA
>Homo sapiens_RAPGEF6(ENSP_296859)
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG
NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN
AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH
PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI
DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV
VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR
TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT
PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLL
WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES
PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN
NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKG
SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP
IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA
VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC
SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL
KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA
SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM
TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRKKRWRSLGSLSQG
STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSL
QWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPI
RKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTL
IPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEH
ASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSS
HDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKS
WTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCV
TSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPA
SLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV
>Pan troglodytes_RAPGEF6(ENSPTRP_29440)
MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG
NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN
AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH
PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI
DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV
VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR
TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT
PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGTKLLEWFKIDSLRDKVTRIVLL
WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES
PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN
NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAGKKSNRHSIQHVPGDIEQTSQEKG
SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP
IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA
VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC
SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL
KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA
SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM
TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLD
VQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGT
LTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKD
PALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDN
LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHS
QHGPGWTLLKPSLIKCLAVSSSVSNEEISHEHIIIEAADSGRGSWTSCSSSSHDNFQSLP
NPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLS
DTYEPNYGTVKRRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDR
YREPPPTPPGYLGISLADLKEGPHPHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLMT
CVPSKIVTQPQRHNLQPFHPKLADVTDADSEADENEQVSAV
>Macaca mulatta_RAPGEF6(ENSMMUP_8111)
MAPTLFQKLFSKKTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD
SSVKRKNEDISVSDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETI
ARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQ
REIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTDNPHPQVTHVSSSQ
SGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRD
LVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILE
DGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVC
IAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIE
EHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFE
GDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGS
EKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKALEILRNNTHLALTVKT
NIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVS
GGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSP
DLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVCHAVHEFGLTGAS
DTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVK
ESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKAGNTHLKRFEDIVNQE
TFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWE
KLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSE
VDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRA
RRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLNEKRS
AKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQK
VLGTTEEVSGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEIS
SRSSIVSNCSIDSMSAALQDERCSSQALPVPEPTGALEKTEHPSGIGDHSQHGPGWTLLK
PSLIKCLAVSSSVSSEEISHEHVIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNS
YRHTHLDDPIAEVEPTDCEPYSCPKSCSRTCGQCKGSLERKSWASSSSLSDTYEPNYGTV
KRRVLESTPTESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPG
YLGISLADLKEGSHPHLKPPDYSVAVQRSKMMHNSLSRLPRASLSSNLMACVPSKIVTQP
QRHNLQPFHPKLADVTDADSEADENEQVSAV
>Mus musculus_RAPGEF6(ENSMUSP_98766)
MNSPVDPGARQALRKKPPERTPEDLNIIYSYLHGMEILSNLREHQLRLMSTRARYERYSG
NQMLFCSETIARCWYILLSGSVLVKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN
SKDNEDSILQREIPARQSRRRFRKINYKGERQTIIDGVDINNYLSLPADLTKMHLTDNPH
PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEEEEI
DRTDPLQGRDLVRECLEKEPADKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMVFEV
VEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMHGAVR
TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT
PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDNLRDKVTRIVLL
WVNNHFNDFEGDPAMTQFLEEFERNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES
PLHFCLTGGSEKGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENITLAKALEILRN
NTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDMEQAPQEKG
NKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP
IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQA
VQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC
SDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTHL
KQFEDIVNQETFWVASEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA
PVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM
TFLHEGNDSKVDGLVNFEKLRMIAKEIRHIIRMTSANMDPAMMFRQRKKRWRSLGSLSQG
STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDIDTDEEKFQMMSL
QWEPAYGTLTKNLTEKRSAKSSEMSPVPLRSVGQTAKVHLHQPHRVSQVLQVPAVNLHPI
RKKGQAKDHVLSTSLPQKGLGPTEEVSVKKHTEDTISVASSLHSSPPASPQNSPRKGYTL
TPSSKCDNLSDSSHSEISSRSSIVSNGSVDSMSAAGQDERCSSHSLAVPEPTGALEKTDH
PSGISDHSQLAHGWMLSKPCLIKGVAVSSSLSSEEMSHEHVVLEAADSGRGSWTSCSSSS
HDNFQSLQNQKSWDFLNSYRHMHLDDPIAEVEPTDCEPCACPKGCSRTCGQCKGSLETNQ
LRQSWASSSSLSDTCEPNYGTVKRRVLESAPAEAPDGLEPRDTTDPVYKTVTSSTDKGLI
VYCVTSPKKGDRYREPPPTPPGYLGISLADLKEGPHPHLKPPDYSVAVQRSKMMLNSLSR
LPPAPPSSHTSAWVPSKIGSQPQRHSHPKLADVADADSEADENEQVSAV
>Rattus norvegicus_RAPGEF6(ENSRNOP_13481)
MNSPVDPGARQALRKKPPERTPEDLNIIYSYLHGMEILSNLREHQLRLMSTRARYERYNG
NQMLFCSETIARCWYILLSGSVLVKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN
SKDNEDSILQREIPARQSRRRFRKINYKGERQTIIDGVDVNNYLSLPADLTKMHLTDNPH
PQVTHVTSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEEEEI
DRTDPLQGRDLVRECLEKEPADKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV
VEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMRGVVR
TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT
PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDSLRDKVTRIVLL
WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES
PLHFSLTGGSEKGFGVFVEVVEPGTKAADAGLKRGDQIMEVNGQNFENITFAKALEILRN
NTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDIEQVPQEKG
NKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP
IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQA
VQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC
SDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTHL
KQFEDIVNQETFWVATEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA
PVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM
TFLHEGNDSKVDGLVNFEKLRMIAKEIRHIIRMTSANMDPAMMFRQRKKRWRSLGSLSQG
STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDIDTEEEKFQMMSL
QWEPAYGTLTKSLTEKKSARSSEMSPVPLRSAGHTAKVHLHQPHRVSQVLQVPAVNLHPI
RKKGQTRDHVLSTNLPQKGLGPTEEVSGKKHTEDTISVASSLHSSPPASPQSSPRKGCTL
TPSSKCDNLSDSSHSEISSRSSIVSNGSVDSMSAAGQDERCSAHSLAVPEPTGAWEKTDH
PSGISDHSQLAHGWMLSKPSLIKGVAVSSSLSSEEMSQEHVVLEAADSGRGSWTSCSSSS
HDNFQSLQNQKSWDFLNSYRHTHLGDPIAEVEPPDCEPCACPKGCSRTCSQCKGSLETNQ
LRQSWASSSSLSDTWEPNYGTVKRRVLESTPAEAPDGLEPRDTSDPVYKTVTSSTDKGLI
VYCVTSPKKGDRHREPPPTPPGYLGISLADLKEGSHPHLKPPDYSVAVQRSKMMLLNSLS
RLPPAPPSSHTSAWVPSKIGSQPQRHSLQPSHPKLADVADADSEADENEQVSAV
>Bos taurus_RAPGEF6(ENSBTAP_0910)
MGEKPDGNKQLLLRKIAAQARITPVLQDLNTIYSYLHGMEILSNLREHQLRLMSARARYE
RYSGNQVLFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMI
VVENSKDNEDNILQREIPARQSRRRFRKINCKGERQTITDDVDINSYLSLPADLTKMHIA
DNPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEE
DEDIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVM
IFEVVEQAGAVILEDGQELDSWYVILNGTVEISHPDGKVDNLFMGNSFGITPTLDKQYMH
GVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIV
IKGTPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLASPLDVGTKLLEWFKIDSLRDKVTR
IVLLWVNNHFNDFEGDPAMTQFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKA
SRESPLHFSLSGGSEKGFGIFVESVEPSSKAADAGLKRGDQVMEVNGQNFENITFVKALE
ILRNNTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDLEQTS
QEKGNKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSL
AIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEV
VCQAIHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMET
ETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLESKTG
NTHLKEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISG
LNLASVARLRGTWEKLPSKYDKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVV
KKDMTFLHEGNDSKVDGLVNFEKLRMIAKEIRQVVRMTSANMDPAMMFRQRKKRWRSLGS
LSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQ
MMSLQWEPAYGTLTKNLNEKKSMKSSEMSPVPLRSAGQTTKAHLHQPHRGSQVLQVPAVN
LHPIRKKGQGKDPATLSTGLPQKILGTAEEVSGGKKHTEDTVSVASSLHSSPPVSPQGSP
RKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSTALQDERCSSQAVAVPESTGA
LEKTEHSSGIGDHSQLGPGWTLSKPSLINKSLAVSSSVSNEEISHEHIIIETADSGRGSW
TSCSSSSHDNFQSLPNPKGWEFLNSYRPTHLDGPIAEVEPTDCEHYSCPKGCSRTCGQCK
GSLETNQMRQSWASSSSLSDTYEPNYGTVKRRVLENTPAESSEGLDHKEGIDPVYKTVTS
STEKGLIVYCVTSPKKEDRYREPPPTPPGYMGISLADLKEGPHLHLKPPEYSVAVQRSKM
MHNSLSRLPPASLSSSPVACVPSKIVIQPQRHKLDVTDGDSEADENEQVSAV
>Loxodonta Africana_RAPGEF6(ENSLAFP_0396)
MNSPVDPGARQALKKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG
NQILFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN
SKGNEESILQREIPARQSRRRFRKINYKGERQTITDDVEINSYLSLPADLTKMHLTDNPH
PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEDEEI
DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV
VEQAGAIILEDGEELDSWYVILNGTVEISHPDGKIENLFMGNSFGITPTLDKQYMHGVVR
TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT
PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIILL
WVNNHFNDFEGDPAMTRFLEEFEKNLEDTRMNGHLRLLNIACAAKAKWRQVVLQKVSRES
PLHFGLNGGSEKGFGIFVEGVEPGSKAADAGLKRGDQIMEVNGQNFENITFVKALEILRN
NTHLALTVKTNIFVFKELLSRTEQEKTGVPHIPRIAEKKSNRHSIQDVPGDIEQTSQEKG
NKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP
IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCHA
VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC
SDEDAQELVKESQLSMLQLSTIEMATQLSMRDFDLFRNIEPTEYIVDLFKLDSKTGNTHL
KEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA
PVARLRGTWEKLPNKYEKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM
TFLHEGNDSKVDGLVNFEKLRMIAKEIRQVVRMTSANMDPAMMFRQRKKRWRSLGSLSQG
STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQIMSL
QCEPAYGTLTKNLGEKRSAKSSEMSPAPMRSAGQTAKAHLHQSHRVSQVLQVPAVNLHPI
RKKGQTKDSVTLSTSLPQKVSGTTEEISGKKHTEDTISVASSLHSTPPASPQGSPRKGYT
LIPPAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALGKTE
PPSGIGDHSQLGPGWTLSKPSLIKGLAVSSSMSSEEISHEHIIIEAADSGRGSWTSCSSS
SHDNFQNLPNPKSWDFLNSYRHTHLDGPIAEVEPTDCDPYSCPVACSRTCGQCRGSLETN
QLRQSWASSSSLSDTYEPNYGTVKRRVSENTPAEPSEGLDAKDGTDPMYKTVTSSTEKGL
IVYCVTSPKKDDRYREPPPTPPGYMGISLADLKEGPHPHLKPPDYSVAVQRSKMMHNSLP
RLPPAPLSSSPMACVPSKIVTQPQRHNLQLCHPKLADVTDADSEADEDEQVSAV
>Monodelphis domestica_RAPGEF6(ENSMODP_32034)
ATESEIGDVDLTGLPEAPVDSEDEEEEDEDIDRTADPLLGRDLVRECLEKEPADKTDDDI
EQLLEIMHQLPAFANMTMSVRRELCSVMIFEVVDQAGAVILADGQELDSWYVILNGTVEI
SYPDGKNESLCMGNSFGIIPTLDKQYMNGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTH
KVEEEGEIVMVQEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSVVDPTYIEDFLLTYR
TFLESPLEVGNKLLEWFKLDSLRDKVTRVVLLWVNNHFNDFEGDPAMTGFLEEFEKNLED
TKMKGHLRLLNIACAAKAKWRQILLQKTSRESPLFFSLSGGSEGFGIFVEGVEPGSKAAE
AGLKRGDQIMEVNGQNFENITLGKALEILKNNTHLSLTIKTNIFVFKELISRTKQEKNGV
PHIPKIAEKKSNRYSIPDMPGDMEQIFPQEKGNKKIKANTVSGGRNKIRKILDKTRFSIL
PPKLFSDGSVSQSQDDSVLGTRQCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPTDI
PDQVIRVFKADQQSCYIIISKDTTAKEVVSHAVHEFSLTGAPETYSLCEVSVSPEGVIKQ
RRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLRESQITLLQLSTIEVATQL
SMRDFELFRNIEPTEYIDDLFKLNSKTGNTHLKEFEDIINQETFWVASEILTESNQLKRM
KIIKHFIKIALHCRECKNFNSMFAVISGLNLAPVARLRGTWEKLPSKYEKHLRDLQDLFD
PSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSKVDGLVNFEKLRMIAKEIR
QVVRMTSANMDPAVMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKK
LYEDAQMARKVKQYLANLNVETDEEKFQIMSLQWEPAYSTLNKNLSERRSTKSSEMSPVP
LRSVGQITKAHLHQPNRMSQVLQVPAVNLYPIRKKGPTKDHIAFGPSASQKIVGMSEEVS
GKKPAEDTLSMASSLHSSPPASPQGSPRKGYAHIPSAKSENFSDSSHSEISSRSSIVSNC
SVDSMSAALQEDRCLPQSLSGVDSVGTAEKKENPPVTTDHIQHVAGWTLPKPSLVKGLAV
PSSVSTEEISHDHITIEAVDSGRGSWTSCSSSSHDNFQNIQNQKSWDLLNSYRHTHLDVP
IAEVEPTNCEPYLYAEGYTLTNCQPKDGTEWVQSRQSWASSSSLSDTYETNYGTVKRRVV
EDSTVEPDETLDSHASTDTTYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYMGIS
LADIKEGPPHHPHLKPPDYSVAVQRSKMVHSNLSRLSSASLGSEPMACISSKIPSQPQWH
ILQPSHPKLAGVTDADSEADENEQVSAV
>Gallus gallus_RAPGEF6(ENSGALP_39237)
DLNTIYSFLHGLDILSHFREHQLRIMSSSARYERYKGNQVLFCSETIARCWYILLSGSVL
MKDSMFLPPCSFGKQSGGKRGCECIILEPSEMIVVENSKDNEESILQREVPLRQSRRRFR
KINQRGERQTITDNVDASSYLSLPADLTKMHLTDNPHPQVTHVPSSQSGCSIASDSGSSS
LSDIYQATESEMGDVDLTGLPEAPVDSEDEEEEEDEDIDRTSDPLLGRDVVRECLEKEPA
DKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVI
LNGTVEISYPDGKSESLCMGNSFGITPSLDKQYMNGVVRTKVDDCQFVCIAQQDYWRILN
HVEKNTHKVEEEGEIVMVKEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIE
DFLLTYRTFLTSPLEVGNKLLEWFTVDSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEE
FEKNLENTKMKGHLRLLNIACAAKAKWRQITLQKPSRDSPLFFSLLGGSDKGFGIFVETV
EIGSKAAEAGLKRGDQIMEVNGQNFENITFAKALEILRNNTHLSITVKTNIFVFKELLCR
IGQEKNGIPHIPKIAEKKNNRYSIPDMPGDVEQMFPREKGNKKLKANTVSGGRNRIRKIL
DKTRFSILPPKLFSDGGVSQSQDDSIVGTRQCRHSLAIMPIPGTLSSSSPDLLQPTTSIL
DFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVSHAVNEFNLTGAPETYSLCEVSV
SPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQISLLQLS
TIEVATQLSMRDFELFRNIEPTEYIDDLYKLDSKTGNAHLKQFEDVINQETFWVAMEILA
EPNQLKRMKIIKHFIKIALHCRECKNFNSMFAVISGLNLAPVARLRGTWEKLPGKYEKHL
RDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSKVDGLVNFEKL
RMIAKEIRQVVRMTSANMDPAVMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARR
SSLLNAKKLYEDAQMARKVKQYLSNLNVETDEEKIQILSLQCEPAYSTLTKNLSERRGAK
SSEMSPVPLRSIGQTTKAHQQNRMSQVLQVPSVNLYPSRKKGLTKDHVTFSTGSPQKSLS
LSEEVSSKKQTDDTMSMASSLHSSPPASPQGSPRKGYALIPSTKSDNFSDSSHSEISSRS
SIVSNCSVDSMSAALQDERSLSQSLLVVDTAGMERKEHSQAEYGQPCPGWSVTRPALIRG
MAFTSSMSNEEISHEHITVEAADSGRGSWTSCSSSSHDNFQNIPNQKSWDLLNSYRHTQL
DGPIAEVDPTNCYSEEAYLYSEAFAKNNRQSKASTELDQSRQSWASSSSLSDTYETNYGT
IKRRGLENSTSEQAEVLDSKPGTDTAYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPP
GYMGISLADIKEGSPHHPHLKPPDYSVAVQRSKMLHSDLSRLSSAPLGSDPVACIASKMP
QWHSRQPSGPQLADMPGADSEEDEDEQVSAV
>Xenopus tropicalis_RAPGEF6(ENSXETP_18397)
DLKTVYSYMHRMDILSHLREHQLRLMSATARYERYSANQVLFCSESLARCWYILLSGSVL
VKNSMFLPPCSFGKQSGGKRGCDCIVLEPSEMIVVENTGENNDGILHRETSIRQSRRRYR
KINQHGERQTITDNGDAASYVLLPTDLSKIHLTDSPHPHVTHVPSSQSGCSIASDSGSSS
LSDIYQATESEMGDVDLTGLPEAAVDSEDEEEDEDIERASDTMLTRDIVRECLEKEPTDR
TDDDIEQLLEFMHQLPAFVNMTMSVRRKLCSVMIFEVVEQAGAIIIEDGQELDSWYVILN
GIVEISHSDGRMENLCMGNSFGINPSLETQYMDGVVKTKADDCQFVCIAQQDYFRILNHV
EKNTHKVKEKGEIVMVNEHRELDRSGTRKGHIVIQGTPERLILHLIEEHSVVDPTYIEDF
LLTYRTFLSSPLEVGDKLLEWFKDDSRRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE
RNLENAKMKGHLRLLNIACAAKAKLRQVTLLKPSRESPFYFNVVGGSDKGFGMFIESVEP
GSKATEAGLKRGDQIMEVNGQNFETIVYAKALEILKNNTHLSITVKTNIFVFKELLNRIG
QEKKNGVPHIPKIAEKKNNRYSIPDLPNDVEQMFPRDRASKKMKANTVSGGRNRIRKILD
KTRFSILPPKPFSDGHVIQSQDDSIVGTRQCRHSVAIMPIPGTLSSSSPDLLQATTNILD
FSNPTDIPDQVIRIFKADQQCCYIIIGKDTTAKEVVIQALHEFSLTGSTDTYSLCEVSVS
PEGVIKQRRLPDQLSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLRESLISLLQLST
IEVATQLSMRDFELFRNIEPTEYIDDLFKIDSKTSAAHLKQFEEVINQETFWVATEILRE
PNHLKRMKIVKHFIKTALHCRECRNFNSMFAIIRSGLNLAPVARLRGTWEKLPSKYEKLL
RDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSKVDGLVNFEKL
RMIAKEIRHVIRMTSANMDPAVMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGGHKKRARR
SSFLNAKKLYEDAQMSRKVKQYISNLSVEIDEEKIQLMSLQCEPAYSTLAKNLSERRSAK
SDLSPAPLRPSGQTTKAHIHQQNRMSQVLQVPTVNLYPMRKKAPTKEHLPCTSGSSQKIS
GLTDEVTVKAQLEDSVSLVSSLHSSPAASPQGSPHKGYAHNPSAKSDNFSDSSNSEISSR
SSLVSNCSVDSMSLTLQDEKCVPHSHAESMGLSERKDVHPSSEYNQPCSSWLHARHPAVR
NFIACASSEDIAHDHISVEPVDSGRGSWTSCSSSSHDNFQTLQKGLDRLSTYRQSHIDSP
IAETESANCSTDETCSEDCTKGKRHSNNSLELNESRQSWASSSSMSDTYETNYGTIKRRV
LDTEEKTEALGQQLDVFYKTVTSTTEKGLIVYCVTSSQKDSRYREPPPTPPGYQGISLAD
IKEGQPHQAHLKPPDYSVAIQRSKMIHKDLSRLSSA
>Takifugu rubripes_RAPGEF6(ENSTRUP_14901)
SSSISSLFVSSILQSPPQRTHQDLHTIYCHLYHMDVLSHLREHQLRSMCTSARYERHGAN
HILFYPDSIATCWYILLSGSVFVKEHMYLARCCFGRQLGGRRGCECITLEPSEMIVVDNG
SEGDDSFLQREGSQRRSRRRFRRINPRGERELITDGQEPSGYTKLPGDLNKMHLTDHAHQ
QVMHVPPSQSGCSIASDSGSSSLSDIYQATESELGDVDLSGLPEAVVDSEEDEEEDEDLE
RASDTLLGRDLVRECLEKDPVDRNDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMVFEV
VEQAGTVILHNKQELDLWYVILNGAVEFSYPDGRMETLCMGNSFGISPSLDKQYMNGEVR
TKGDDCQFVCIAQEDYWRILNHVEKNTHKVEEEGEIVMVKEHRELDRSGTRKGHIVIKGT
PDRLIMHLVEEPSVVDPTYIEDFLLTHRTFLSNPMDVGKKLFEWFQVDTLRDTVTRIVLL
WVNNHFNDFEGNPAMTRFLEDFEKLLETTKMKGHLRLLNIACAAKAKLRQITLQKASRDS
PLHFSVQGGSERGFGVFVDSVEEGSKAAETGLKRGDQIMEVNGQNFDNISITKAVDILRN
NTHLSLTIKTNIFVFKELLSRVMHEKKNGGPHIPKIQEKKGNRFSIPDLPGDMEFPSDHK
SNRKLKANTVSGGRNKIRKMLEKTRFSILPPKPFSDGGMVQSQDDSIVGTKQCRHSVAIM
PIPGNLSSSSPDLLQPATSVLDFSNPADIPDQVIRVFKADQQSCYIIISKDTTAKDVVAH
TVNEFGLVAAPETYSLCEVSVSPEGVIKQRRLPDQLSKLADRIQLNGRYYLKNNMETETL
CSDEDAQDLLRESQISLLQLSTMEVAAQLSMRDFDLFRNIESTEYVDDLFKLDTSIGSGN
LKQFEEVINKETFWVASEILKEPNALKRMKTIKHFIKIALHCRECKNFNSMFAIISGLNL
APVARLRSSWEKLPSKYEKLFGDLQDVFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKD
LTFLHEGNDSTVDGLVNFEKLRMIAKEIRHVVRLTSANMDPALMFRQRKKRWKSLGSLSQ
GSTNSNMLDVQGGAHKKRVRRSSLLNAKKLYEDAQMARKVKQYLSNLTVETDEEKHQVMS
LLCEPSYSTLSKYLSERRSTKSDMSPVSLRSALPSAKTQNRVSQVLQVQVPLNHLRKKST
AKDTGTPNSNSPQVVKKPPVSSSEEWSSKRPSDDAVSLISSLHSSPTVSPHGSPRKGYAF
LPASKADNLSDSSHSEISSRSSICSVDSMPAPGPDDRCSSGNRTAAGAAMPSPAAVADGT
AATYTHSNADYSQPSTSNSSPLARGYVPRGSTFTSSASTEELTPDHASLDSVADSGRSSW
TSCSSNSHDSFQSLPPSSCRPWDHGIHGHPLAFAHLGGFKHTQLAGPIAEIEAATQAWMN
EDAAAKQHSRNSSSDLSNQSRQSWASSSSLSDTYEGNYGTIKRRNTAEHPSSPTSEEGGQ
STDHVYKTVTSSTEKGLIVYCVTSPAKDERYRAPPPTPPGYQGLALGDLGLADAVVSGPG
GLGPRPPHLRPPDYSVALQRSKLLQSPGASGGLAEARRLAANRLLQHQEDRSSGSTQGHS
RPASICLPAQDLADSDDGTHEQVSAV
>Tetraodon nigroviridis_RAPGEF6(ENSTNIP_19179)
LGQSESVQLPGDLNKMHLTDHAHQQVMHVPPSQSGCSIASDSGSSSLSDIYQATESELGD
VDLSGLPEAAVDSEEDEEEDEDLERASDTLLGRDLVRECLEKDPVDRNDDDIEQLLEFMH
QLPAFANMTMSVRRELCSVMVFEVVEQAGTIILHNKQELDLWYVILNGAVEISYPDSRME
TLCMGNSFGISPSLDKQYMHGEVRTKGDDCQFVCIAQEDYWRILNHVEKNTHKVEEEGEI
VMVKEHRELDRSGTRKGHIVIKGTPERLIMHLVEEPSVVDPTYIEDFLLTYRTFLSNPME
VGKKLLEWFQVDTLRDTVTRIVLLWVNNHFNDFEGNPAMTRFLEEFEKLLETTKMKGHLR
LLNIACAAKAKLRQITLQKASRESPLYFSVQGGSERGFGIFVDSVEEGSKAAETGLKRGD
QIMEVNGQNFENIPITKAVDILRNNTHLSLTIKTNIFVFKELLSRVLHEKKNGGPHIPKI
QEKKGNRFSIPDLPGDMECPLTQEPRKCSNTVSGVSFLSPFNSNPPLTPIPALLCSDGGM
VQSQDDSIVGTKQCRHSVAIMPIPGNLSSSSPDLLQPATSVLDFSNPADIPDQVIRVFKA
DQQSCYIIISKDTTAKDVVAHSVNEFGLIAAPETYSLCEVSVSPEGFIKQRRLPDQLSKL
ADRIQLNGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTMEVAAQLSMRDFELFRN
IESTEYLDDLFKLDTSIGSRNLKQFEEVINQETFWVASEILKEPNTLKRMKTIKHFIKIA
LHCRECKNFNSMFAIISGLNLAPVARLRSSWEKLPSKYEKLFGDLQDVFDPSRNMAKYRN
VLSSQSMQPPIIPLFPVVKKDLTFLHEGNDSTVDGLVNFEKLRMIAKEIRHIVRLTSANM
DPALMFRQRKSLPPSCMSLSQGSTNSNMLDVQGGAHKKRVRRSSLLNAKKLYEDAQMARK
VKQYLSNLTVETDEEKFQFMSLQCEPSYSTLSKYLSERRSTKSDMSPVSLRSALPSAKTQ
NRVSQVLQVQVPLNPLRKKSNAKDTGPPNSNSPQVVKKPPVSSSEEWNTKRPSDDTVSTV
SSLHSSPTVSPQGSPRKGYTFLPAGKADNLSDSSHSEISSRSSICSVDSMPAPGPDERCS
GTNRTAAGVATTTPAMVTDSTAHTHFNADYSQPSTSNSSPSARGYVPRGSAVTSSASTEE
LTPDHTSLDSVADSGRGSWTSCSSNSHDSFQSLPSSSCRPWDHGIHGHPLAFAHLGGFKH
TQLAGPIAEMEAATQAWLKEDGAAKQHSRNSSSDLSNQSRQSWASSSSLSDTYEGNYGTI
KRRNASEHPSSPTNEEGGQSTDHVYKTVTSSTEKGLIVYCVTSPSKDERYRAPPPTPPGY
QGLALGDLGLADGSASGPGGLGPRPPHLRPPDYSVALQRSKLL
>Homo sapiens_RAPGEFL1(ENSP_394530)
MLIHPRGLPSSSHRRKINSTYFYILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEGPE
GLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQL
VETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIR
SRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINS
HLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDY
VFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQD
LLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPP
VIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNH
LQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
>Pan troglodytes_RAPGEFL1(ENSPTRP_15539)
MEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTL
RLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHS
YVTIRSRLSASVQDILGSVTEKLQYSEEPTGREDSLILVAVSSSGEKVLLQPTEDCVFTA
LGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHEL
EFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALC
KQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVIS
KMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDME
ASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
>Gorilla gorilla_RAPGEFL1(ENSGGOP_4973)
GGPSGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEPPPEEGGEPAGVAEEPGSGGPCWLQ
LEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLNRVLERLAG
GATRDSAASDILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEGPEGLGRKQACLAMLL
HFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVETVELKIPEENQ
PPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGS
VTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLFACTRDSYEAL
VPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETAN
LELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDN
AAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLT
FLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVI
DNQNLLFELSYKLEANSQ
>Mus musculus_RAPGEFL1(ENSMUSP_103103)
MKPLEKFLKKQTSQLAGRAVTGGPGGGPGCCGGPGGGGGPGGGGGPAGGLRPLQRRQSVS
RLLLPAFLREPPTEPGLEPPVEEEGGEPLGVSEEPGSGGPCWLQLEEVPGPGPIGSGVPL
RSPSSYSSDELSPGEPLASPPWAPLGAPERPEHLLNRVLERLAGGTTRDSSASDILLDDI
VLTHSLFLPTEKFLQELHQYFVQSRNVEGPEGLGRKQACLALLLHFLDTYQGLLQEEEGA
GHIIKELYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRI
DSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAERED
ALILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEVQVSPGDTEI
HRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVA
TEVLLCEAPGKRVQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGK
FKNLFRKFEGLTDPCRNHKSYREVISKMKPPLIPFVPLILKDLTFLHEGSKTLVDGLVNI
EKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVIDNQNHLFELSYKLEAN
SQ
>Bos taurus_RAPGEFL1(ENSBTAP_20265)
MKPLEKFLKKQTSQLAGRTVAGGPGGGPGSCGGPGGGGGPGGGGGPAGGPRPLQRRQSVS
RLLLPAFLREPPAEPGLEPPPEEDGGEPTGVAEELGSGGPCWLQLEEVPGPGPLGGGGPL
RSPSSYSSDELSPGEPLTPPPWAPLGAPERPEHLLNWVLERLAGGATRDSAASDTLLDDI
VLTHSLFLPTEKFLQELHHEFLQAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGA
GRIIKDLYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFHRI
DSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGRED
SLILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSFEALVPLPEEIQVSPGDTEI
HRGEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVA
TEVLLCEAPGKRAQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGK
FKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNI
EKLHSVAEKVRTVRKYRSQPLCLDMEASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEAN
SQ
>Loxodonta Africana_RAPGEFL1(ENSLAFP_20681)
MKPLEKFLKKQTSQLAGRTVTGGPGGGPGSYGGPGGGGGPGGGGGPAGGTAPLQRRQSVS
RLLLPAFLREPPAEPGLEPPPEEEGGEPAGVTEEPGSGGPCWLQLEEVSGPGPLGGGGPL
RSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLIRVLERLTGGATRDSAASDILLDDI
VLTHSLFLPTEKFLQELHQYFVRAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGA
GRIIKDLYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRI
DSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGRED
SLILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEIQVSPGDTEI
HRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVA
TEVLLCESPGKRAQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGK
FKNLYRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNI
EKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEAN
SQ
>Monodelphis domestica_RAPGEFL1(ENSMODP_16388)
PTERFLQELYHFVQSDGIEGAEGLGRKQACLAVLLHFLETYQGLLQEEECAGRIIKDLYL
LIMKDESLYQDLREETLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRIDSCLQTRVA
FRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVSEKLQYSEESGGREDSLILVAVAS
SGEKVLLQPSEDCVFTTLGINSHLFACTRDCYEALVPLPEEIQVSPGDTEIHRVEPEDIA
NHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEPL
GKRAQLLKKFIKIAAICKQNQDLLSFYAVIMGLDNAAVSRLRLTWEKLPGKFKNLFRKFE
NLTDPCRNHKSYREVVSKMKPPVIPFVPLILKDLTFLHEGSKTLLDGLVNIEKLHSVAEK
VRTIRKYRSRPLCLEMEASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ
>Xenopus tropicalis_RAPGEFL1(ENSXETP_58901)
MKPLEKFLKKQSSHLSGPRHLHRRQSVSKILPSFLRDTPGDSSGGERCEEDPSGGPPPSQ
DCLELPDGLRSPLSFSSDELSPSEPLTPPPGSGGWTLSPPGPLLAPDTPEALLGRVLEQL
LSAPRLNEAAELALDDFILTHTLFMPTEELLLQLQQRLASCLRYTTPAWEGSDPLQRKQA
VLSSLLHLLDIYKDALQEEERTFQLIKDFYVLVMRDAPNFPQLEGSVIRLHRLVESAELR
LTDGSATQCSKQVKPLFRHFRRIDSCLQPRVAFRGSDEIFCRVYMPDHSYVTIRSRLSAS
VSDILTSVSEKLQYSEEQGQREEPLILVAVTSAGDKVLLKPDDGCIFTTLGINSHLFACN
REELRSLVPLPEEVQLPPEDSHIHRIEAEDLANQLSAFHWELFSCVHELEFIDYVFHVER
GRRETANLELLLQRCSEVQHWVSTQTLLCEGPARRTQLLKKFIKTAAICKQNQDLLSFFA
IVMGLDNGAVSRLRVTWEKLPGKCKNLFRKFENLTDPCRNHKSYREMVSRMRPPVIPFIP
LILKDLTFLHEGSKTFIDGLVNVEKMHAIAEKVRTVRKYRSNQLRLDTDVSPTHLQNKAY
VRQFQVIDNQNLLFELSCKLEPNTQ
>Danio rerio_RAPGEFL1(ENSDARP_100483)
MPAGMKPLEKFLKKQTNALTRAGGFGEKATGTGASRRRASLSRVVPFFRETSPESGPARE
VFSPETEEAPCWPSATADIRSPSLSSDEQSSEASLDTNWTPLPADTPENLALALLDSVAG
KRYANCTEILLDDFMLTHPIFLAPDKFQQVLLQQFSSEGKQGEGWPGWDGAERKLAVLTV
AFRYLDTYRDLLQEEGDRSNTFPKELYLCAVDELNRFPELVEDVLKLQRWTEILHSPAEE
DKESRKKQVRPLFRHFRRIDACLQPREAFRGSDEIFCRVYTPDHSYVTIRSRLSCRVGEI
LALVKEKLQYSEDQPTQPANLILVAVTSSGEKAVFRPSDEAVFTTLGVNTHLFACEPAEL
ESLIPLPEEIHWTPGDSKLHDMSAEEVANQLVVFDWELFSCVHEVEFVCYVFHGEQARWR
PLNLELILQRCSEVQHWVATEILQCQSLPKRIQLLRKFIKIAALCKQQQDLLSFLALVLG
LDNPAVSRLRLTWEGLPGKFRKQFQQFESIADPSRNHKSYRDLLASLRAPLIPFTPLLLK
DLTFLHESCKTFHGELVNFEKMHKVAEMVRSIRRYRSSQLAMEAEPSPSHLQTKAYVRQL
QVIDNQNLLFEMSSKLEPKDM
>Tetraodon nigroviridis_RAPGEFL1(ENSTNIP_5787)
DGVRRKRAVLSVAFRYLDTYRELLQEEGDRSNSFPKELYLCAVEQLRRYPELVEDVLKLQ
RWTEILNCPSDEEKETRKKQVRPLFRHFRRIDACLQPREAFRGSDEIFCRVYTPDHSYVT
IRSRLSCRVGEILALVREKLQYSEEQPVLPGNLVLVAVTSAGEKAVFRPSDEAVFTTLGV
NTHLFTCEPSELDSLLPLPEEIHWSPGDSKLHDMSAEEVATQLVVFDWELFSCVHEVEFL
CYVFHGEQARWRPLNLELVLQRCSEVQHWVATEILQCQSLPKRVQLLRKFIKIAALCKQQ
QDLLSFLAVVLGLDNPAVNQLRLTWEGLPGKFKKQFQQFESIADPSRNHKSYRELISSLR
PPLIPFTPLLLKDLTFLHESCKTFHGELVNFEKIDVVSRDVRGPTKACFKPAAMDTETSP
SHLQTKAYVRQLQVIDNQNLLFEMSCKLEPRDT
>Gasterosteus aculeatus_RAPGEFL1(ENSGACP_1453)
SAPLFLSQLHETFSLETQGEEGGGGGSEVARKRAVLSVVFRYLDTYRELLQEEGERSNSF
PKELYLCAVQELSQYPELVEDVLKLQRWTEILNSPSVAEKESRRKQVRPLFRHFRRIDAC
LQPREAFRGSDEIFCRVYTPDHSYVTIRSRLSCRVGEILALVREKLQYSEDQPVLPGNLV
LVAVTSAGEKAVFRPSDEAVFTTLGVNTHLFTCEPSELDSLLPLPEEIHWTPGDSKLHDM
SAEEVANQLVAFDWELFSCVHEVEFVCYVFHGEQSRWRPLNLELVLQRCSEVQHWVATEI
LQCQSLPKRVQLLRKFIKIAALCKQQQDLLSFLAVVLGLDNPAVSRLRLTWEGLPGKFRK
QFQQFESVADPSRNHKSYRDLITSLRPPLIPFTPLLLKDLTFLHESCKTFHGELVNFEKM
HKVADMVRIIRRYRSSQLAMDTETSPPHLQTKAYVRQLQVIDNQNLLFDMSCKLEPKDT
>Ciona intestinalis_(ENSCINP_1063)
MYSYLIQTKPDIITEHQSDEEISGLADDDVVTYRNCCFGHELVAWLCGYIKTTNLALISE
LSRFHVNGLWQVLLEEGLVYHVRHEQYFEDTRYLYQFHNEVTEYAQTAEELEVTEDKMGW
VLAYLNQSSPDTMLRTALRKLPEHRTSEELELIYDEILHMKALTQLSDQVKQQLAAVLQF
EFYHKSGETIFHQGDEGRSWYIISKGSVDVVIQGKGVVCTLHEGDDFGSLAIVNDAPRAA
TIVTTKPNCQFLRVDKYDFNKIHEEVESKTVRLKEHGKDVLILQKSLKTKEGGTSAYVGS
RGQKRYNISAGTAEKIVNHILESLQPWVKPRHEENLEDFLLTFRFFTTTQKLCDLLLQRY
NSEVVNGAECSRSLKKRVVYLVVRWSYISTHLFIQDLVVQNFLQVLRENIAEDIQKNLAY
LELQIRFSCDQCNSCQYFNSDEVGNVLTVGETIQRYPSPSSHDEQCAIHDNDEVLLKIYD
LQSSYTTVKVPICLTCEETVNAACEKINRSPNKMLLFEVQENNDIHAIPKHQMSVATSTK
LNSRLYMCIPDERDELASIQLPPPTIQPTTCMETVSSLEIAYHVTQHDWQLMNNIHLPKL
LSFIPINNRLFSSLKMYGNMFGFMAVMIGIGNQAISRLHGTWDKLPTKYRKLVDEFETIL
DPSRKHRNYRVFVSSTNSARIPYFPLLMKDLTFQHEGNDTFNKNGLVNFEKMHMLSNSIR
LVVHGCSRSLDIIQPACSVLSSKTNKVIISPLNNQFFESTKTAEESRNYTREVSVITNQI
LLNEMSNKLEP
>Ciona savignyi_RAPGEFL1(ENSCSAVP_13142)
EESQQISEEELVSALADLKRKSPDAMFRSALRKLPEHRTATELEMIYDEILHINALKELS
NEIKKQLTKVIQFEFHQQVGTTLFHQGDEGRSWYVILSGVVDVLIHGKGVVCSLHEGDDF
GNLAIVNDAPRAATIVTAQPNCQFLRVEKFDFVKILNEVEAKTDRLKEHGKDVLILEKNS
LKSRSGSMADTLTPSNYKYSIARGTVDKILEHILRYIQPWVLTGMEDSMEDFIITYKLFT
DSKHLCEYLLKQYRAGDSLKKGVVYFVVRWSHIHTYIFHEDPDIQSFLKELRKQVIQDVL
ENEIYEELQEDLECVYKPHGKPGLLNRRSSNNGTSGASQVVLTVGTSVQRYPMSKQNGAE
PIHDSDKVLLKIYDWNNTYTTVKLPISATCGEIIAAACEKLSNSPSDFKLVELHENHDTN
EIPKRQTSVATAVSLNSRLYLTTTGDHPYLVNKQSASKTIEASHMETVSSLEIAYHLCKH
NWNLMNNIHILEFLFKTCGGHKFKWTTSNLNVMARRFNQLAYWPPTEICLCANINKRVQL
LRKFIKWDTYLKMYHDMFGFMAVMIGIGNQAVSRLHDTWDKLPSKYRKMVQGFEGILDPS
RNHRNYRLFVASTESTRIPYFPLIMKDLTFMQEGNDTFKDDLVNFEKMRMTSKLIRQVVD
GCRNPLEVDNLLETTKTAGTTKKYAITCPVITNQVVLNEMSNTVEPKRT
>Branchiostoma floridae_(XP_02600702)
MVQQWSRIVGDAFIESKTIKAFLEELCLAVSEDCQTWPELKEDLAALEKLMSSMPEKSRASISGTLRRLP
KELSEEKQTRRRRIKPSDENIFKVYFADHTYSTLRLAISASAEETVQSTAEKLCLGEDLVLCEVKSTGER
VVLKESDVSVTTGLSLNGRLFIAPREHLDSLTPLPEQEGPKQSTCATIELMSSREMAYQMTLYDWELFNC
VHENELIYHIFGRHKFGKITSNLDLLLRRFNEVQFWVVTEMCLTPQVGKRVQLLRKFIKIAAYCKEYQNL
NAFFAIIMGLGNIAVSRLSQTWERLPNKFKRMFAEFESFMDPSRNHRVYRLAMSKLQPPIIPFIPLLMKD
MTFTHEGNKTYYDGLVNFEKMHMISSTIRTIRQCGSEPFNFDPPPVVKNIQEVRNYVRSLNVIDNQRTLT
QLSHKLEPRRS
>Strongylocentrotus purpuratus_(XP_784278)
MEMLLSHRVITVPPPPPKTALLHPESSPSVDSQGRSRRSSRKSRSPSPQRTSPARTHDGLDPIHPALPIV
KVPSDKQSHTGTIFRTLILAKSPNLIKDRKNNLRTYRKCMVGSEMVDWLMQQGQMTLVRSRPQAIGMWQA
LLEEGVITEVNREHPFQDAEHQYRFREDDLGITSTPTSSQKKAAEEELPEIVGILAKVAPDAMMRLILRK
PPQERSVDDLEIIYEELLHIKALAHLSGMVKRQLTSVLVFECHEKAGTVLFHQGDEGRSWFIILRGSVNV
VKYGKGVVCTLHDGDDFGKLALVNDAPRAASIVLREDNCQFLRVDKYDFNRILRDVEANTVRLKEHGQDS
LVLEKIPTSTQHSNNNKHHHVSYRYSVMAGVPEKMLEHLLETRIDSKYDPTDTFLEDFLLTHIVFMPSEK
LCPALLQHYHSERTSSRGPEQETIDHIVNNKRRVVQLVCLWHVVAGYAFKQDTTIMQFLETLFSAVCDDC
PAYPSLQDPLASLEQVLKAVKSTKDSGSHTWQVQTQVLSESRTHQEDELRRTPIKAKDETIFKVYCADHT
YTTLRVHMDTSVTNIIQTVSEKMCLGNDLVLCEVKSSGERLSFHQKDVCIATSLSCNGRIFITLRDHLDA
LTPLPEQEGPSEGSVSFLEPTSSRELAYQMTMYDWQLFLCTHECEFIYHTFGRHKYRRITANLDVFLRRF
NEVQSWIVTELCLTSHISKRVHLLKKFIKIAAHCKEYQNMNSFYAIIMGLSHMSVSRLAQTWDKLPNKLK
RVFSDFEALMDPSRNHRVYRLALSKMRPPIIPFMPLLIKDMLFTHEGNKTYFEGLVNFEKMHLVASIMRV
VKYCRSENFKLDSPPAVKNVKEIVSYVRNLQVIDNTKRLMQLSYTLEPPKT
>Drosophila melanogaster_(FBpp0302889)
MDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGR
FWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELL
RVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPI
TETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTR
AQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHI
REALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIF
VFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPR
AATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKY
TVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHE
DAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEET
SIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYC
ADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTG
LSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHE
YELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAY
CKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFV
GKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEP
PSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL
>Apis mellifera_(XP_392340)
MHRPPHPHPITDHRQVNLVFDDTFSQGLTGRPELYQKSNRSSHSSDTSSAYSGSDTMTSVQGSLDADPDA
DDVDLSGLVESIVDSDEEEDLAESMDSLTVRDPVRECLEKDPMERTEDDIETLLEFTQQLKAFTNMTLAV
RRALCAVMVFAVVERAGMIVLNDGEELDSWSVLINGAVEIEHSNGEIEQLHLGDSFGILPTMERLLHRGV
MRTKCDDCQFVCVTQADYFRIQHQGEENTRRHEENGRVILVTELRGALDGGARRGHVVIRGTPERLMLQL
IEENSITDPTYIEDFLLTHRTFIDSPLLVASQLLEWFDQAQVRDRVARVVLLWVNNHFTDFETDPAMMEF
LEAFEAGLEREKMQGQQRLLNIACAAKARTRNVTLARPTRDEVLHFSILGGYERGFGIFISKVDKKSKAE
DVGLKRGDQILEVNGQSFEHVNHARALEILRGSTHLSITVKSNLLAFKEMLQMPDDSPRPRGRANKSEIS
RLQSDPRARLSTHVDTVTPVNPLNPLVGGVPLLIPDSNVSPCKDAKKEHKGFMTLGPKKKLQKALIKMNI
LPKNTINDGVHVDDPLAPPHTPPGTGGLAQTTNLYHSKSNPDLTSLYCYDDLRAPDYPEHVLKVYKADQT
CKYLLIHKETTAHEVVMLALQEFGITEGSSNFSLAEVSVGEGGMIKQRRLPDQLQNLAERIGLSSRYYLK
TNGISETFVADEQAPELIRESQVHFLQLNAVEVAIQLTLQDFSIFRQIESTEYVDDLFELKSRYGVPMLR
QFAELVNREMFWVVTEVCSEHNLVRRSKIIKQFIKIARQCKECKNFNSMFAIVSGLGHGAVSRLRASWEK
LPSKYQRLFSDLQELMDPSRNMSKYRQLVASEQTQPPIIPFYPVVKKDLTFIHLGNDSRVEGLVNFEKLR
MIAKEVRTLTNMCSSPYDLSIMLERGGQPPSSAMVALNQMTTGNQGGQTATVKRRKKSTAAPNPKKMFEE
AQMVRRVKAYLANMKVITDEERLHALSVECEPHAGAAAVAAVPLNASRGRRHPSPTLSTTSSASSTSEGR
KSIQGTKFGAASPQAVRKMLALSDPHKTRPYQPKHCPPPLPVPGLALHSSGLEPSPGAPRRVGSGSRVPM
HERSHSDTPSSLPPPVDLSAESSSVTSLSNLQPLRKTLTSGSVTSSDSGHSTQLDSHSGSSVEAGGSPPP
PQRRHSAMQGSVLRGGAPPFPHAVAVLPPLPANHNQNHNHNHHHHHHHHHHHHHHQHYYDHHHHQPQNPQ
GFSGTTGLGVGLGVPAALPPPGAGTTIMTTMTTMTTMTSMTTMRPGIGSAQCRQPPAYKVAAQMARLHRL
GRAHSHEGVTYRNDHEDDDEESAQVSAV
>Anopheles gambiae_(XP_308514)
PCDRNLRDCELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRYWYAVLGGQLEVRY
HAADTKDGKLSVTLCNLGVGATFGESILHDLPRDSTVVTKTTCELLRVEQQDFRLIFEKNKELMNDIITN
CRLKNGFGQSMQTTSTVQTNVQQQPSPTKKQLSPDHPNPAAPITEIPSPAMSRMGWALRTLLVSDNTSCL
KDRKVGGKFIRKCAPGTELVEWLLNLSPIVHTRTQAAGMWQALLEEGVLCHVAKEQPFKDKCFLYRFKSD
EDGTAGGAPTSDDVNHANEHIREALPALLHRGPDATLRMILRKPSHERTQEELELVYEELLHIAALSHLS
TSIKRELASIIVFEAHAHAGTVLFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKEGDDFGKLALINDAP
RAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLILERVAKQRGYSAFKYTVMSGTPQKM
LEHLLETRLGGQAGPNDPFLDDFLLTHIVFMPTPLLIDELAANYHADADIDLRQASEEDQEYFLTSKRRV
VQFIQRWVLAVRHAVFDDPLAVEFIEELATDVEAEPALQEEASIIHHVLTQLSRYQEDRQMNATQKWKLP
PNGQPICLFSGNTHSKTVIRPDDDIIFRVYCADHTYCTLRFPMATTAEVIKACAADKLQIARLPEDLLLV
EVKSSGERVVFKDNDVSVPTALSLNGRIFVSPKDHLDALTPLPEQEVPTEAPDVDFEALSTKDVAYHMTL
FDWDLFWAVHEYELLYHTFGRHHFNKITSNLDVFIRRFNEIQYWVVTEIVSTTNLTKRMSLVKKFIKLAA
FCKEYQNLNAFFAIVMGLSNTAVSRLSMTWDKLPSKFRKLFTEYEALIDPSRNHRAYRMSVGKLQPPVIP
FMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRAVRFCRSRHLVLDPPSPKNENEIRNYIRCFRTI
DNQRVLNSMSQKVEPRRS
>Caenorhabditis elegans_(T20G5.5)
MERIVSRVRRLSPLHTFSDALLISLLSESDFQPDSIQQGVVLFEKDEPTEYWYLLLSGEV
QLYSKTYTGDFNHLKTLRCGALFGDLSTLTHSCSCLVTRPAQLIRIAQNHFLSVYNKHGD
HLQPFIIIMHDILTDETPSDPIHPHSSGLFNGQRSMDLISTEINPSEIVSVSTNGMLSKM
ILPSIPNQREKPMNRVVVNQQKNEERNFIEFHNPTGIEKQIRDSGGILHRKMLTDNHQVI
RDITTEHTRVQNCMIGAEMIDWLLTLFVSTSTTCSSLSRIQMSAIWQVLLNNGLISHIDG
EHQFLDKTNSYYRWVQQFRSRNKVAPSIEEVSKSITLLSSVAPETLFLMIVSKPGFERSP
EELEVVYEELTFIKALSHLSTMVKRQLSNFVKVEQYVHAGSVVFRQGEIGVYWYIVLKGA
VEVNVNGKIVCLLREGDDFGKLALVNDLPRAATIVTYEDDSMFLVVDKHHFNQILHQVEA
NTVRLKDYGEDVLVLEKVDIPRGAALENSNSCNFNCGYSVMAGKAEKILEYVLETRIDAL
GDDISELDVFVEDFILTHDAFMPDNTVCNFLKSYYFRTPYRATRDSITDSCTEEVRCKRR
VVQFVYVWCSLLRVNFFLNPVTNSFVEELFCHVIDDRKRLGGMEDILTRIGSIRSTRENM
QLVLARHPAIVLDCGVLSAHTPCPVLPSDVCNQIIYLADTTCFVLPIRVDKTAEEICELS
RRRMSFSAEPLNLVEVKSNGEKLIFSPNDRAIPTVLSLNSKLYVVNREEIPLLVPMEDQN
GPTPSSHSSILHLIDSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPFNLDLL
VRRFNEVQHWSTTEILLATEENRMEILKKFISIATIAREYRDLLTVFAITLGLSHTSISR
LTLTWSKLPPASLKTFSELENLLDPTRNHRMYRLLVSKMSSPYIPFVPLILKDLMFIHQG
NKSFYNGLVNFEKMHMFAKIFRSFRQCKSQMDNGAEHEFIEPQSLIRNLRVIDNQKKLMQ
LSYEIEPKSAPKRNVIFH
>Nematostella vectensis_(XP_01629461)
DLMVNMVYLQNELVFKKVHPHVVRQICFYAYYEDLEPGTVLYRQDAKGLNWYAILTGSVNICVSQTSKIE
DAVTLCCLGPGSTFGESVLDGSPRTATAITNDYCELLCVNGEYLKTIFQQNRRYLVGIELPGEQCNTVEV
TEADGESTLKLELQLKLSQIMLNAAVVLHNKMVKSAPHLFKERSCNSGTFPDCFAGSEAVDWLLDSSRQV
HSRFHAVSVFQALLEEGRDHHNLDQRDHHYRNQCDHHYRDQRDHITVTSVTIITVTSVTIITATSVTIIT
VTSVTIIGVISVPNARSQEDVDTIYEELLRIKSLSYISSTVKKEMAAAVVLESCEHKGTVLFNQGDEGDS
WYIILKGSVNVVVLGKGIVCQLHTWDDFGRLSLVNNAPRAASIETCEDNCHFLRVSKETFDNILKDVESS
SLVLKEHGSDVLVLEEFKDRVPVNEKGQFKEKSYYAVMAGTASKMVDYLLQIPTNKETEKIVNNVFLYRH
RSPSQRSLSLSFSTHQHHHQNNYYHHHHHHHHQHRHLQRMLRVSWEFRGSKGLFMTSAEDFCIRRLVYTF
LAHSCNTAFLCYILENRPTMKKSRHMFQRNIVFQRRTMSFSSRRGGTADLKQPRRSKMTPIEKDDYVTFR
VYCADHTYSTVRMRYGDTAQMIVDTAKERLLLGDDCVLCEVKSSGERLVFQGNEISVITRISINSKLFIA
PKEHIDSLTPLMEQEGPECGTRLIEVISSREIAYYLTQYEYELFERCNIYEFIYQSFDREKFGQISANLD
ICLSRFNEVHYWVITEICLATQLSKRVFLLKKFIKIASYCKDYKNLNSAFAIIMALNCAAISRLTQTWEK
IPNKYKKLYRELDAILDPSGNHRVYRLVVAKMKPPVIPFMVLIMKDITIINYGNKTFVNELVNFEKMRMI
TISLRLVEYCRSAPFDTPAPSSLKIPSEVPSYVRNLQVIDNGKTLTQLSYRLEPPTNN
>Hydra magnipapillata_(XP_02155415)
MDSDDEILPNESAAVRDIVRDCLEKEPGERTENDINILMDFMQRLPAFNKLTHNIKVEMCKVMVFAVVDE
AGAIVMSDGEEMDSWSVILNGSVEILYEDQPPKTLHLGDSFGVKTTQEQMFHKGVMKTRVDDCQFVCIAQ
NEYWRIFSHGEASCRKVEEEGEVVMVTEHRVQDGGSRQGQVVIKGTPERLLDHLMEDHSVIDPTYVEDFL
LTYVVFFNKSHDIASKLLKWFERPQLKDKVTRVMLLWVNNHFSDFEGDVFMESCLERFEYLLEAKKMLGQ
LRLLNMACSAKSKPRIINLQRLSKETHLDFSICGGREKGFPIFVSKVNYDSKAAELGLKRGDQIIEVNAQ
ALDQFSCSKAIDFLMSNAHLCLTVKTNTIGFKEVIQPTAKKTQSSHGSLDETVLSQQIGALDLRVSNNKL
GTSTISRSSSDVNNVKGNKKAKNFSDMTDSLASISGSSTLPKNSKLKRAMLKFSFMPRSPSERELNKLDY
QDSTQPFTRSFTKPSQDSHNQTNADDNHSTDDEYEDTVIKVYRSDHTSKFFILRKDTIAKQVVISALEAF
GITDYASKSYFLCEVTVTEDGLIKQKRLPEKTSNLASRISLNSRYYIKASISEGPISDEVAQEIAREANF
NLLQLTPLDVAKELTLQDFDLFRNVDSREYIYNLFESNNERKSKNLRCVEQTTNTEMFWVISEICLESNI
AKRVKLLKYYIKVAKYCKDFKNYNSMYAVISGLANTAISRLKHTWEKLPQKHEDMFQDLLDLMDPSRNMS
KYRNMFTGEQCYPPIIPWFPIVKKDMTFLHLGNDTHVDGLVNFEKLRMIAREVRRVYNPGENNVALSVVS
IMTGAPNRRSGRGFVKDPKKTYEEIQTSRKIRQYLEKLSSRHYTEKELIEMSYNCEPPLTLTAPGVSQRS
RSKPPPLTNSNKSAEDKSESSRTNSVSSLESTVTSNQPPRRKLPTPTSSTTSAETSSLPGSRNFRPPYSF
TANEDQVDSVLYDNGVEQLSGVEKFPEDLLIRNKWIVAICSKHFIQESYIVCGWSSKKQLKKDAILGIK