>Homo sapiens_METTL2A(ENSP_309610)
MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
SEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSA
TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ
LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
YRVWIQCKYCKPLLSSTS

>Pan troglodytes_METTL2A(ENSPTRP_46684)\t
MAGSYPEGAPAVLADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
SEVCECRNNEDGPGLIMEEQHKCSLKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
LRFKKGQCLSGNFYVRGDGTRVYFFTQEEPDMLFTTAGLEKVQNLVDRRLQVNRGKQLTM
YRVWIQCKYCKPLLSSTS

>Macaca mulatta_METTL2A(ENSMMUP_12829)
MAGSYPEGAPAVLADKRQQFGNRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSTQ
RVCQEKQVDYEINAHKYWNNFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
RSEVPECRNNEDGPSLIMEEQHKCSSKSLEHKTETPPVEENVTQKISDLEICADEFPGSS
ATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNPEYDPSRCFAFVHD
LCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMA
QLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDMLFTTAGLEKVQNLVDRRLQVNRGKQLT
MYRVWIQCKYCKPLLSSTS

>Mus musculus_METTL2A(ENSMUSP_21030)\t
MAASFPEGVPETEDGKRPQFGHRFLSDPARVFHHNAWDNVKWSEEQAAAAERKVQENSSP
LVCPEKQVDYEVNAHKYWDDFYRIHENGFFKDRHWLFTEFPELAPSHSHLTGVPLEKQRS
DVCEDGPGLTAEQHKCSCASPGCETQVPPLEEPVTQKLGHLEISGEEFPGSSATYRILEV
GCGVGNTVFPILQTNNNPNLFVYCCDFSATAIELLKTNSQYDPSRCYAFVHDLCDEDQSY
PVPEDSLDVIVLIFVLSAIVPDKMQKAISKLSRLLKPGGVMLLRDYGRYDMAQLRFKKGQ
CLSGNFYVRGDGTRVYFFTQGELDTLFTAAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQC
KYSKPLALRSSQHVPIPHATESSSHSGLL

>Rattus norvegicus_METTL2A(ENSRNOP_8140)
MAASLSEGVPETEDRKRPQFGNRFLSDPARVFHHNAWDNVKWSEEQAAAAERKVQENSSQ
LVCPEKQADYEVNAHKYWDDFYKVHENGFFKDRHWLFTEFPELAPSHDHLVNLHLEKQKN
EVSKPRSSEDGPGLAAEQHKRPCTSHGCETRVPPVEEPVTQKLTHLEICADDFPGSSATY
RILEVGCGVGNTVFPILQTNNNPDLFVYCCDFSATAIELVKTNSEYDPSRCFAFVHDLCD
EDQSYPMPKDSLDVIVLIFVLSAIVPDKMQKAISKLSRLLKPGGVMLLRDYGRYDMAQLR
FKKGQCLSGNFYVRGDGTRVYFFTQDELDTLFTAAGLEKVQNVVDRRLQVNRGKQLTMYR
VWIQCKYSKPLVPSASQHVPTPHTT

>Bos taurus_METTL2A(ENSBTAP_12443)\t
MDCSFPEGDPAAVCGKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAEAERKVQENSTQ
RVCQEKQADYEINANKYWNNFYKIHENGFFKDRHWLFTEFPELAPSQNHLKNLLSENKRS
EVYEYYRSGEDGPDLTIEEQHRCSSVSLGDKTQPPLTEESVTQKLHHLEICANEFPGSSA
TYRILEVGCGVGNTVFPILQTNNDPSLFVYCCDFSSTAVELVQTNSAYDPSRCFAFVHDL
CDEDKSYPMPENSLDVIILIFVLSAIVPDKMQNAINRLSRLLKPGGIMLLRDYGRYDMAQ
LRFKKGQCLSENFYVRGDGTRVYFFTQDELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
YRVWIQCKYRKPLGSSTG

>Loxodonta Africana_METTL2A(ENSLAFP_9391)
RALKSPLRVPNGKREQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAEKKVRENSAQRMP
QEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKGLLSEDKKSE
IPEYRSSEDGPGLTTEEQHKSSSSSRRDKTQAPSVKNITQKLSHLGICADEFPGSSATYR
ILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAVELVQTNSEYDPSRCLAFVHDLCDE
DQSYPMPRDSLDIIILVFVLSAVAPDKMQKAVNRLSRLLRPGGMMLLRDYGRYDMAQLRF
KKGQCLSENFYVRGDGTRVYFFTQDELDTLFTAAGLEKVQNLVDHRLQVNRGKQLTMYRV
WIQCKYRKPL

>Monodelphis domestica_METTL2A(ENSMODP_12855)
MADSCPESVSATTRDKRVQFGNRFLNDPARVFQHNAWDNVEWSEEQEAEAERRVRENSAQ
RVPPEKQVDYEVNAHKYWNNFYKIHENGFFKDRHWLFTEFPELTPNQNKSNLKNLLLKDG
DFEIIEHRNSGNGLGLIVSNTQEQHKASSHSVDDKEQKHPIEETTQNTCHLDINTDGFPG
SSATYRILEVGCGVGNTVFPILHTNNDPGLFVYCCDFSTTAVDLVQTNSEYDPSRCFAFV
HDLCDEEKSYPMPRESLDVIILIFVLSSIVPDKMQNAITRLSYLLKPGGMILLRDYGRYD
MAQLRFKTGRCLSENFYVRGDGTRVYFFTQDELDTLFTTAGLEKVQNMVDHRLQVNRGKQ
LTMYRVWIQCKYRKPFSPNIS

>Danio rerio_METTL2A(ENSDARP_6586)\t
MAAPAVAADSPVIENMPETAGGATENSAEAQKRPQFGTRFLTDPRQVFQHNAWDNVEWSA
EQEEAALKKVQENSQPLPAEKQEEFDDRANEYWNDFYTIHENRFFKDRHWLFTEFPELAP
QQKHLRGAEEKESLEHMLNGEDVSSNHTHDEFPGASASYRILEVGCGVGNTVFPILKTNN
DPGLFVYCCDFSSTAVDLVKSNPEYDPSRCHAFVHDMSDESGEYPMPDHSLDVIVLIFVL
SALHPEKMQKSINRLGRLLKPGGVLLLRDYGRYDMAQLRFKKGRCLSENFYVRGDGTRVY
FFTQDELHDLFSSAGLEKLQNLVDRRLQVNRGKQLTMYRVWVQCKYRKVLAPT

>Takifugu rubripes_METTL2A(ENSTRUP_41779)
MAAPHAAVAGEAGSGDTELSLASSISEDGKRPQFGTRFLTDPRQVFQHNAWDNVEWTEEQ
EASAKKKVLENCQPLPSEKQEEYENRANEYWNDFYTIHENRFFKDRHWLFTEFPELCPQC
SPNNVTHQKVSSTGRCVQDEERAKQGAAVSPINVNFPGATASYRILEVGCGVGNTVFPIL
KTNNDPELFVYCCDFSSTAVDLVKTNPEYNLGRCFAFVHDLSDVEANYPIPDGTLDVIVL
IFVLSALHPIKMQASISRLARLLKPGGVMLLRDYGRYDMAQLRFKKGRCLSDNFYVRGDG
TRVYFFTQEELHSMFTEAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYHKPLVPS
\t
>Tetraodon nigroviridis_METTL2A(ENSTNIP_14674)
MAAPDAVAGVEAGGGDTDLALASSITEDGKRPQFGTRFLTDPRQVFQHNAWDNVEWTEEQ
EASAKKKVLENSQPLPSEKQEEYENRANEYWNEFYTIHENRFFKDRHWLFTEFPELCPQW
NSSVNDQEVSSTGAGFLDEEQTKKITAVPHIINAHFPGATASYRILEVGCGVGNTVFPIL
KTNNDPDLFVYCCDFSSTAVDLVKTNPEYDPGRCFAFVHDLGDVEADYPVPNGTLDVIVL
IFVLSALHPNKMQASISRLSQLLKPGGVMLLRDYGRYDMAQLRFKKGRCLSDNFYVRGDG
TRVYFFTQDELHSIFTGAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYRKPPAAIPDA
VEGGTEHNHN\t

>Gasterosteus aculeatus_METTL2A(ENSGACP_11931)
LTDPRQVFQHNAWDNVEWSEEQEASAKRKVSENNQPLPQEKQEEYDSRANEFWNGFYTIH
ENRFFKDRHWLFTEFPELAPQCSLDNESHLEVSDSDHSQQERLQREHRSEVPSLSHTDGD
IPGSLATYRILEVGCGVGNTVFPILKTNNDSGLFVYCCDFSSTAVELVKTNPEYDPGRCF
AFVHDLSDVEADYPVPEGTLDVIVLIFVLSALHPDKMQASISRLARLLKPGGVMLLRDYG
RYDMAQLRFKKGRCLSENFYVRGDGTRVYFFTQDEVHEMFTEAGLEKMQNLVDRRLQVNR
GKQLTMYRVWIQCKYRKAPAQPLGSDGQVRGKDPPSSTIA


>Oryzias latipes_METTL2A(ENSORLP_4128)
MEAPCAVDAVAAGSSETGHSLSGSSSAESRRPQFGTRFLTDPKQVFQHNAWDNVEWTDEQ
EEAAKRKVSENSYPLPAEKQEEYDSRANEYWNEFYTIHENRFFKDRHWLFTEFPELAPQC
SVLNHTSHIDEPQGSNLDQNRCRDSGAEDSRDFPGSSASYRILEVGCGVGNTVFPILKTN
NDPGLFVYCCDFSSTAVELVKNNPEYDPGRCFAFVQDLSDADASYPIPDGSLDVIVLIFV
LSALHPDKMQASIRRLARLLKPGGMILLRDYGRYDMAQLRFKKGRCLSENFYVRGDGTRV
YFFTQDELHELFTRAELEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYKKAS

>Homo sapiens_METTL2B(ENSP_262432)
MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA
TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
CDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ
LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM
YRVWIQCKYCKPLLSSTS

>Homo sapiens_METTL6(ENSP_407613)
MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK
QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK
PGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV
NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS

>Pan troglodytes_METTL6(ENSPTRP_51546)
MASLQRKGLQARILTSEDEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVK
QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK
PGKSVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV
NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS

>Gorilla gorilla_METTL6(ENSGGOP_18607)
MASLQRIGLQARILTSEEEETLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDSNIFAYACDFSPRAIEYVK
QNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLK
PGKSVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVV
NEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS

>Macaca mulatta_METTL6(ENSMMUP_6545)
MTSLPRKRLQARVLSSEEEEKLKRDQTLVSDFKQHKLEQEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREFEDQKLTILEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAVEYVK
QNPLYDTERCKVFQCDLTKDDLLDHVPPGSVDVVMLIFVLSAVHPEKMHLVLENIYKVLK
PGKSVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAQLFMDTGYEEVV
NEYVFRETVNKKEGL

>Mus musculus_METTL6(ENSMUSP_77138)
MASFQRKGLQARILSTEEEEKLKRDQALVSAFKQQKLEKEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREYEGQKLTLLEAGCGVGNCLFPLLEEDLNLFAYACDFSPRAVDYVK
QHPLYNAERCKVFQCDLTRDDLLDHVPPESVDAVTLIFVLSAVHPEKMRLVLLNVYKVLK
PGRSVLFRDYGLNDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAQLFVDAGYEEVV
NEYVFRETVNKKEGLCVPRVFLQSKFRKPPKDPAPTSDSASL

>Rattus norvegicus_METTL6(ENSRNOP_26413)
MTSLQRKGPQTRILSTGEEEKLKRDQALVSAFKQQKLEKEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREYEGQKLTLLEAGCGVGNCLFPLLEEDSNIFAYACDFSPRAVDYVK
QHPLYNAERCKVFQCDLTRDDLLDHIPPESVDAVTLIFVLSAVHPEKMHLVLLNVYKVLK
PGRSVLFRDYGLNDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAKLFVDAGYEEVV
NEYVFRETVNKKEGLCVPRVFLQSKFRKPPKDPAPTTDSASLLRKEF


>Bos taurus_METTL6(ENSBTAP_31765)
MAALQRRGLQTRILSSEEEEKLKRDQALVSDFKQQKLEKEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREFEDQKLTILEAGCGVGNCLFPLLEEDPDIFAYACDFSPRAVEYVK
QNPLYDTERCKVFQCDLTKDDLLEHVPPESVDVVTLIFVLSAVHPDKMHLVLQNIYKVLK
PGKSVLFRDYGLYDHAMLRFKAGSKLAENFYVRQDGTRSYFFTDEFLARLFLDTGYEEEV
NEYVFRETVNKKEGLCVPRVFLQSKFRKSQKNPIPVTPDLGHES


>Loxodonta Africana_METTL6(ENSLAFP_5157)
MASLQRKGLQARMLSSEEEEKLKRDQALVSDFKQQKLEKEAQKNWDLFYKRNSTNFFKDR
HWTTREFEELRSCREFEDEKLTVLEAGCGVGNCLFPLLEEDLNIFAYACDFSPRAVEYVK
QNPSYNTERCKVFQCDLTKDDLLEHVPSESVDVVMLIFVLSAIHPDRMQLVLQNVYKVLK
PGKCVLFRDYGLYDHAMLRFKAGSKLGENFYVRQDGTRSYFFTDEFLAQLFTDTGYEEVI
NEYVFRETVNKKEGLCVPRVFLQSKFRKPPKHPAPTSPGPGPESQVL

>Gallus gallus_METTL6(ENSGALP_18802)
MFHENTSADCLSTLTTSTEDGAFQTKGHNTRILSPEEAERLANDRVLVSDFKQLKLEKEA
QKNWDLFYKRNSTNFFKDRHWTTREFQELKACREFADQKLTILEAGCGVGNCLFPLLEED
LNIFAYACDFSPRAVEYVKKNSLYSTERCKVFQCDLTKDDLLENIPADSVDVVTLIFVLS
AIHPDKMHLVLKNIYKVLKPGKCVLFRDYGLYDHAMLRFKSGSKLGENFYVRQDGTRSYF
FTTEFLSQLFRAEGYEEVVNEYVHRETVNRKEDLRVPRVFLQSKFQKPFSKT\t

>Taeniopygia guttata_METTL6(ENSTGUP_4070)
GAFQKKGHSARVLSPEEAEKLAKDQVLVSDFKQLKLEKEAQKNWDLFYKRNSTNFFKDRH
WTTREFQELKACREFADQKLTILEAGCGVGNCLFPLLEEDMNIFAYACDFSPRAVDYVKK
NALYNTERCKVFQCDLTKDDLLDNIPADSVDVVTLIFVLSAIHPDKMHLVLRNIYKVLKP
GKCVLFRDYGLYDHAMLRFKSGSKLGENFYVRQDGTRSYFFTEEFLSQLFKAEGYEQVVN
EYVQRETVNRKEDLHVPRVFLQSKFQKP

>Anolis carolinensis_METTL6(ENSACAP_2716)
SGGFPKRGHKMRTLSPEEAERLAKDPVVVSDFKQQKLEKEAQRNWDLFYKRNSTNFFKDR
HWTTREFEELKACREFDDQKLTILEAGCGVGNCLFPLLEEDLNIFAYACDFSPRAVEYVK
QNPLYDPQRCKVFQCDLTKDDLLENVPPDSVDVATLIFVLSAIHPEKMHLVLCNIYKVLK
PGKCVLFRDYGLYDHAMLRFKSANKLGENFYVRQDGTRSYFFSDDFLAELFLSAGYKQVV
NEYVLRETVNKKEGLCVPRVFLQSKFQKPHKE

>Takifugu rubripes_METTL6a(ENSTRUP_9410)
KESESISSVLGQDTKATNRVLTQEEMDKLDGEVLVSDFKQIKLEKEAQKNWDLFYKRNST
NFFKDRHWTTREFEELKACREFASQQLVLLEAGCGVGNCIFPLLDDELNIFVYACDFSPR
AVEFVSKNPLYSPERCCAFQCDLTKDDLRENVPEGSVDVITLIFVLSAVHPDKMKLVLQN
ISRVLKPGGIALFRDYGLHDHAMLRFKSGSKLGENFYVRQDGTRSYFFSK

>Takifugu rubripes_METTL6b(ENSTRUP_4417)
SVLGQDTKATNRVLTQEEMDKLDGEVLVSDFKQIKLEKEAQKNWDLFYKRNSTNFFKDRH
WTTREFEELKACREFASQQLVLLEAGCGVGNCIFPLLDDELNIFVYACDFSPRAVEFVKK
NPLYSPERCCAFQCDLTKDDLRENVPEGSVDVITLIFVLSAVHDKMKLVLQNISRVRTFK
NVIVSFICKAQ

>Tetraodon nigroviridis_METTL6(ENSTNIP_15967)\t
MCRFEKQSIRNRVLTQEEMDKLGAEVLVSDFKQIKLEEEAQKNWDLFYKRNTTNFFKDRH
WTTREFEELKACREFAAQRLVLLEAGCGVGNCIFPLLEDDLTLFVYACDFSPRAVEFVKK
HPLYCPERCCAFQCDLTKDDLRQHVPEGSVDVITLIFVLSAVHPDKMTLVLQNISRVLKP
GGILLFRDYGLHDHAMLRFKAGSKLGENFYVRQDGTRSYFFSKDFLAKLVEEAGLQPVAN
DYVLRETVNKKEGLCVPRVFLQSKFTKPSQSRSL

>Gasterosteus aculeatus_METTL6(ENSGACP_2217)
MALSQRGRFPGESEASHPKEDVGSNGELPPRLPGRNQSSTAESVPPRGERDGLGGSAAPA
SGFRLRKLEEEAQKNWDLFYKRNTTNFFKDRHWTTREFQELQACRELEAQRLVLLEAGCG
VGNCLFPLLEDDRDVFVYACDFSPRAVDLVKKNPLYTPERCCAFQCDLTKDDLRTQVPEG
GVDVVTLIFVLSAVHPDKMQLVLQNISRVLKPGGVVLFRDYGLNDHAMLRFKARSKLGEN
FYVRQDGTRSYFFSKELLAELFAGAGLQSVSNDYVLRETVNKKEGLCVPRVFLQSKFTKP
GQSQGC

>Oryzias latipes_METTL6(ENSORLP_19425)
MNRAEDTESTDDTPTCLSGQTKTSSSRDLTQEEQGRFKTERVLVSEFKQIKLEKEARKNW
DLFYKRNATNFFKDRHWTTREFEELKECREFESQKLVLLEAGCGVGNCLFPLLEDDLNIF
VYACDFSPRAVEFVKQNPLYCPERCCAFQCDLTKDDLTGNVPEGSVDVVTLIFVLSAVHP
EKMKLALENINKVLKPGGVVLFRDYGLHDHAMLRFKAGSKLGENFYVRQDGTRSYFFSKE
HLAQLFKEAGFVSVVNDYVLRETVNKKEGLCVQRVFLQSKFTKAALPQVSCSPVFPGSGK

>Homo sapiens_METTL8(ENSP_364407)
MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK
SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK
PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ
NLVDRRLQVNRKKQVKMH

>Pan troglodytes_METTL8(ENSPTRP_21587)
MNMIWRNSISCLRLGKVPRRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA
ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK
PEEKARESSWDHVKTSATNCFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK
HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLQNSPESFLYCCDFASGAVELVK
SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK
PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ
NLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSDMVSTLLSQD

>Macaca mulatta_METTL8(ENSMMUP_38167)
VKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDLVNTSAT
NCFSRMHCPTMPEEKNHYEKSSGSSEGQSKTESDFSNLDGLFPGSNATFRILEVGCGAGN
SVFPILNTLQNSPESFLYCCDFASGAGELIKSHSSYRAAQCFAFVHDVCDDGLPYPFPDG
ILDVILLVFVLSSIHPDR

>Mus musculus_METTL8(ENSMUSP_107804)
MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDA
ARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQN
TKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEP
FPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQC
SAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRMQAVAHRLSRLLKPGGMLLFRDH
GRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEIRRMFCEAGLHEKQNLVDHRLQVN
RKKQVQMHRVWIQGKFQKPSPWTPQSGN

>Rattus norvegicus_METTL8(ENSRNOP_8140)
MNVIWRNCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPTKVFEHNMWDHMQWSKEEEDE
ARKKVEENSATRVAPEEQVKFENAANKYWDTFYQTHKNKFFKNRNWLLREFPEILPVDQN
TKEKLGESSWDPARSSISRTQGTETHRQETFVSSEPGSRERSASNPDLEEYSRGPRKAEQ
FPGSKATFRILEVPCLGDKTGTPVFNQRRNIPGSFLYCCDFAPEAVELVKSHEAYSEAHC
SAFIHDVCDDGLAYPFPDGTLDVILLVFVLSSIHPDRMQAVIHRLSRLLKPGGMLLFRDH
GRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEIHRMFCEAGLHEKQNLVDHRLQVN
RKKQIQMHRVWVQGKFQKPSCWTPRSAD

>Bos taurus_METTL8(ENSBTAP_21849)
MNVIWRNYISCPRMRKVPHRYQSGCHPVAPLGSRILTDPTKVFEHNMWDNLEWCTEDLAL
SRRKVYDNTAIRIIQNESLKYESEASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVGQK
TEEKVKELSWNHVKINAESFFSKMHCPTMPEEKNHYKESSGSSDGQSKAGSDFSKLDSEE
YRERPLKTELFPGSNAAFRILEVGCGAGNSVFPILNTLQNVPEFFLYCCDFASGAVELVK
SHASYRAAQCCAFVHDVCDHGLPYPFPDGTLDVILLVFVLSSIHPDRMQGVINRLSKLLK
PGGMLLFRDYGRYDKTQLRFKRGHCLSENFYVRGDGTRAYFFTKGEVHNMFCKAGLDEKQ
NLVDRRLQVNRKKKVKMHRVWVQGKFQKPLHLTQKSSNLVFSVLSHE


>Loxodonta Africana_METTL8(ENSLAFP_2618)
MNVIWRNSISCLKIGKAPHRYQSDYRPTAPLGSRILTDPTKVFEHNMWDHMQWSKEEEEA
ARKKVEENSAVRVLLKEQEIHFHFSALKYRSIFYKIHKNKFFKDRNWLLREFPEILPVDQ
KTTEKVGELSWDHVKTNTANCFSRMHCPTMPEGKNHYKKNPGSSNGRSKAESDFSKPDSE
EHRKGPLKTDLFPGSNATFRILEVGCGAGNSVFPILNILQNVPGSFLYCCDFASGAVDLV
KSHSSYRAAQCSAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDSFSFF

>Monodelphis domestica_METTL8(ENSMODP_35585)
MNAIQRLWASSLRKRRMWVRFQSNDRPAVPLGSRILADPAKVYEHNMWDHMEWSQEEEEA
AREKTTENSSVRVQLEDQVKYENQASKYWNNFYEIHKNKFFKDRNWLLREFPEILPVGLQ
TKEEKEKMSWDCVKTDPTDSFLKTDCLAVPKRIESYKNDFGDNFTYSQSKIRSSDSQHPN
KKKEEAAKTKLFPGSCATFRILEVGCGAGNSVFPILNALKNAPETFLYCCDFASEAVELV
KSHSSYSPAQCSAFVHDVCDDGLSYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL
KPGGMLLFRDHGRYDFTQLRFKKGYCLSENFYVRGDGTRAYFFTKGEVHNMFHQAGLDEK
QNLVDRRLQVNRKKKVKMYRVWVQGKFQKPLHSFHHNHSDNCIPGISAG

>Danio rerio_METTL8(ENSDARP_6586)
MRGLVKLTARAVSFIPCRQCGGGRPPAPLGGRILSNPDDVFKHNMWDHVQWTEEEREKAR
QKAEENSEEKIPVEEQSKYDREAHKYWDQFYEMHQNKFFRNRNWLFTEFPELLPPDTGGM
LMAEQEQGLESVNREKHDYKDTYPGHHAAFRILEVGCGAGNSVFPIINTIRGSKAFLYCC
DFSSRAIELIQKHPDYDPAVCHAFVRDICDATSPFPFPPESLDIILVVFVLSAIHPARAQ
AVVRGLAGLLKQGGMVLFRDYGRYDLSQLRFKKGQCLSENFYSRQDGTCVYFFTKDEVHG
LFSAAGLEELQNLEDRRLQVNRGKKILMHRVWMQSKYRKPEK

>Tetraodon nigroviridis_METTL8(ENSTNIP_14674)
LCSTITTRFKGTDGRPSAPLGSRILTSPDDVFNHNMWDHIQWTEEDIENARQKAEENSSV
QIPLHEQRKFDFQAREFWDKFYTMHQDKFFKDRKWLLFEFPELLPSGATNMPHASGASTD
TENQQRHHNSPAHHQKQTSGDPSSCQGADAEKDEDSRRTFPGQHASFRILEVGCGVGNSL
FPIIHSIRETNAFLFCCDFSPCAIRLLKANPEYDECVCHAFVHDICEETACLPFPPQSLD
AILAVFVLSAIHPDRLQGVVNRLSSYLKHGGIFLFRDYGRYDFSQLRFKKGQCLSENFYT
RGDGTCVYFFTKGETHHLFTNAGLEEVQNLQDRRLQVNRGKKVAMLRVWTQSKYRKP

>Gasterosteus aculeatus_METTL8(ENSGACP_6633)
MHQLQSFSVAKVLSRLSSRLHSTRGRPSAPLGSRILTKNDDIFKHNMWDHVQWTEEEKEN
ARQKAKENSSTQIPLKEQGTFDTEACQYWDKFYQMHQERFFKDRKWLFLEFPELLPYGAK
GQNANGRLGDQQASHPRPTGSSPTDTETRLQQPNGPTHHHRNTTPPDHQGAAPEKNKAPK
QTPTFPGQQSSFRILEVGCGVGNSVFPILSSIKETDAYLYCCDFSPCAIQLVKDHPDYSD
SMCHAFVHDICEEASFPFPPKSLDVILAVFVLSSIHPERTQGIVKRLSTYLKHGGIFLFR
DYGRYDFSQLRFKKGRCLSENFYTRGDGTCVYFFTKGEVHDLFSSAGLEEIQNLEDRRLQ
VNRGKKVAMHRVWMQSKYRKL

>Oryzias latipes_METTL8(ENSORLP_21635)
LAPSFAVKFKNTKPRPVAPLGSRILTNTDDIFKHNMWDHIKWTVEDKENARQKVQENSSV
QIPAPERGKFDAEACQFWDKFYEVHQSKFFKDRRWLFLEFPELLHPSHRENRVTNVHHEH
KVIQIQSGCTADTEKRHYQHNDPTGGSWKINNWNYQEAQQELKDVPSFLGHDASFRILEV
GCGVGNSVFPILNNIRNTDSFLYCCDFSARAIQMVQDHQDYDKSICHAFVHDICEEGSSF
PFPPQSLDVILAVFVLSSIHPERLQGVVNRLSSYLKPGGMFLFRDYGRYDFSQLRFKKGR
CLSDHFYTRGDGTCVYYFTEEEVGDLFSKAGLEEIQNLEDRRLQVNRKKKVAMRRVWIQS
KFRKPSLHFLPEHSP

>Ciona intestinalis_(ENSCINP_17418)
MDDTKRPTFGNRFLKDDAQVFLHNAWDNVEWTEEQESNARQITTAQAENSMPDEEQEKFL
SEAPKFWDKFYEKHENKFFKDRHWLFTEFPELLLVKESKDNEELLCNDDTNDGELLSNNE
TTVGSFPGSDSKVKFMEIGCGVGNTIFPILKVNNENLFMYGCDYSQTAVDIVKNHKEFNP
KSAFVFVHDISTEDEFPIPNESLDVVIMIFVLSALQFRKMGGAVKRIAKLLKPGGVILFR
DYGRYDMAQLRFKHRRCISDNFYTRGDGTMVYFFTQGEVKEIFTSAGLMEEQNLVDRRLQ
VNRARQIKMYRVWVQAKYRK

>Ciona intestinalis_(ENSCINP_15087)
MEDFESKSQYTSSQVRSLSDDELQMLENQNKRLVTEFRSQKLEVEAKKMWDLFYKRNTTN
FFKDRHWTSREFGEIEQRIHNNQQTVLLEAGCGVGNAIFPLMAQAKDLFVYACDFSPRAV
ELVKDNPSYSETKCKAFQCDLGTDHLSYTIQENSVDLVTLIFVLSAIHPDKFEFVLRNIH
KVLKPGGYLLFRDYGLNDWAMLRFNNGSKISENFYVRQDGTRAYYFKKEELESLTCASGF
DVVSNEYVMRETINKKKNLKVPRVFLQGKYQKPAPT
\t
>Ciona savignyi_(ENSCSAVP_8728)
ESSQWTTEEVRPLTAEEKVMLEKQVSLLVSDFRRDKLELEARKMWDLFYKRNSVNFFKDR
HWTTREFNEIEERIKSNEHTVLLEAGCGVGNAIFPLMDKYSNLFVYACDFSPRAVQHVKD
NPGFSKKNCNAFQCDISTQSLCDNIQENSVDLVTLIFVLSAIHPNKFEFVFENIHKVLKP
GGYLLFRDYGLNDWAMLRFSTGSKIAENFYVRQDGTRAYYFKKGELENLASSNGFLVSSN
EYVMRETVNKKKNLKVPRVFLQGKYQK

>Branchiostoma floridae_(XP_02606144)
MYCCDFSATAIDIVKQQPDYNTRRCHAFVHDLTDTTSSLPFPPASLDIIIMIFVLSAIHPDKMQSTVDHL
AKYLKPGGKLLFRDYGRYDLAQLRFKKGRCLSDNFYVRGDGTRVYFFTQDELRTLFGSAGLQEELIHVDR
RLQVNRGRQVKMYRVWLLCKFTKPLD

>Drosophila melanogaster_(FBpp0072696)\t
MLTTSSSTMLGKYGWQILRRLASKSWEHTRQRKKPSGAGSRVLTDAREVFEFNAWDHVQW
DEEQELAAKAAVAKNSTSKMEAEQKERFQTDAPKFWDSFYGIHDNRFFKDRHWLFTEFPE
LAPLAADSAVLQPRSIFELGCGVGNTILPLLQYSSEPQLKVFGCDFSARAIEILRSQRQF
DEKRCEVFVMDATLDHWQVPFEENSQDIIVMIFVLSAIEPKKMQRVLDNCYRYLRPGGLL
LFRDYGRYDLAQLRFKSGKCMEDNFYVRGDGTMVYFFTEEELRGMMTQAGLQEEQLIVDR
RLQVNRCRGLKMYRVWIQTKFRKPL

>Drosophila melanogaster_(FBpp0111303)
MEPLEPDVITTQAKELSAVERQKLDEQNKRGLVPEYKANKLEIDAQRNWDIFYKRNETRF
FKDRHWTTREFQELLDQEEFHEKRTLFEVGCGVGNLVFPLLEEQTSEEGCFSNSRFFFYA
CDFSPRAVEFVRSNPLYDPSQISAFQCDITTQQVHDHIPPSSVDICTLIFVLSAIHPQKF
KDVVQNLGKLLKPGGLLLFRDYGLYDMAQLRFKPGNKIAENLYVRQDGTRSYFFSEEEVS
KLFQENGFEVITNAYVHRRTLNLKEGVDVPRIFLQGKFRRKNL

>Anopheles gambiae_(XP_316017)
MTETTEETIPTDQSEQPSVRPQFGNRFLSAGDDVFQHNAWDNVQWDEEQENAALEGVKKNSSVKLSDAEV
TRLETEADQNWDRFYGIHQNRFFKDRHWLFTEFPELAPAKGPNTVPERVLPDGEPVKRAEEVSQESDGQQ
RSRTIFEIGCGVGNTVFPILKYSEEKNLMIYASDFSRQAIDIMCQSPEYDTNRCKAFVLDATADRWDVPF
AENSIDIVVLIFVLSAIDPERMQHVVNQIARYLKPGGMVMLRDYGRYDLAQLRFKPGKCLKDNFYVRGDG
TLVYFFTQEDLRTLFTSAGLVEEQNIVDRRLQVNRGKMVKMYRVWVQVKFRKPTDN

>Anopheles gambiae_(XP_318925)
QVELTSHPRLAYRHTQFSKGFSTPKQSLSFKSEPSFCRYEKSKQPRSLAKGTNGTQKAFNLGDVVTDAAK
ILTEEERTKLEEQNKRLVTPFQALKLEQEARKHWDLFYKRNENRFFKDRHWTTREFSELLAGEDPAAAAS
SSPLAKPDNVERISVEKKLLEIGCGVGNLIFPLIEDGHRDYFIYACDLSPRAVELVQKHNLYDERYMKAF
ACDITTEEVFQTLPEASLDIVTLIFVLSAIHPEKFQSTVANIYRLLKPGGVVLFRDYGLYDMAQLRFKPG
HKIAENFYMRQDGTRSYYFAEEEVSKLFCQTGFTVMVNSYIHRRTVNPKENIDVPRIFVQGKFLKPEQT
\t

>Apis mellifera_XP_624474)
MEEDISKHQQNESNNKRPQFGNRILSNNNNVFQHNAWDNIIWDEEQQNLAKQKVNENSTITMSDEKIWEY
EHEAYKYWDKFYGIHENKFFKDRHWLFTEFPELAVDIVKQNIKQPLRFKNENIKKNGQETHENILDLPSK
NGNKILEIGCGVGNTVFPILLYNTDANLFVYCCDFSAKALDILKQNSAYDTSRCKAFILDVTQEEWETPF
EPESLDIIVLIFVLSAINPEKMKHIIEQIHKYLKSGGLVLFRDYGRYDLAQLRFKKGSCLANNFYVRGDG
TRVYFFTQEEIRILFTSCGFIEEQNLIDRRLQINRGKQLKMYRVWIQGKYRK

>Apis mellifera_(XP_623532)
MAESMKSEYASHVAKQLTEEEIVKMRAQNSRLVSEFRANQLEKDAKKHWDLFYKRNDTRFFKDRHWTTRE
FDELLNLNTKNEQNVLFEVGCGVGNFVYPLIEDGLKFKMIFACDLSSRAVELTKNHSLYDPENMKIFQTD
ITTENCFLEVNYPVNIATLIFVLSAIHPKKFRKVVENLYNVLDKGGIVLFRDYGLYDMAQLRFKPGHKIS
ENLYMRQDGTRTYYFSEKEVSNLFRSVGFEVLTCHYVQRRTVNFKEKIDVPRIFVQGKFVKPPRHPRPPP
LPPLDDSMLGRNTFGCEGGGALVPTRGDSPSPRPFFHHVRGDLYIKALFWVAKASETTISLTYPVPYLTD
KQLAYRNNTLFRINMRSLVILVLVAVAISRVSCRELKGDKRSSRLPLKGKRGIVDYSGGSSYNSPLISSG
YTGGYSSAHSPSIPSIQSLGGGTMGYSLGSGGLGHNFGISLGGQHFGGAQSYSSPGLGSLAGGGGLFSPP
SKNGPVTFGIHGGGGSSSSTSYSAPVYATGVHGLSSYGSGSSHQGISLSSMLGSGHSYGLPASSLGSGHA
LSMIHSISPGYAASGGLVIDSSSLGKGSSSYSLPLSSSHGSSSLSTGSSSSYALPVSSGSSHSGISALHS
GSTASYSLPVSSGSSIGGHISFSGGSSADSYSLPASSISASHPYVTVMSDASSSSSGSSSYSSPSSSYSA
PASGSISSYSSPASSYSSSGYSGTSSSYSPIYSAPSTSYGTPMESHGSYSNLAARYVEYPGSKSYEDSTS
SNKYDTISYSSPSGKY

>Strongylocentrotus purpuratus_(XP_780030)
MILGCHFLKHGLALGSKIIRHRKGFSTSVHAYQVRGDENLHVKELLEERNHQYPSSDSGKIMSAGEELPV
TKDDAASVKRPQFGNRFLENPDNVFQHNAWDNVAWDPEQLEAAKKKVGENSSQQVETEKKELYEADADRY
WNEFYSLHQHKFFKDRHWLFTEFPELSSDNAQASAKECSSERGASQETSEPRTMDSLTTGGSNTSAEATE
RKNEDCEHGPTSSRTSRSESGTDEIHAASDDFPGKSAHKRILEVGCGVGNTIFPILQTNADPGLFVYGCD
FSSVAVDIVRQHAEYNPSRCHAFVCDVSDPAASFPVPDNSLDLVVLIFVMSAINPDRFLSTIQTLTRLLK
PGGRILFRDYGRYDLAQLRFKKGRCLSENFYVRGDGTRVYFFTQDELRELFISAGLVEEQNTIDKRLQVN
RGRQLTMYRVWIQCKYRKP

>Strongylocentrotus purpuratus_(XP_794407)
MEKEKDGGGWVTTKQPRDLTEAEKQKLAEDETCVSDFKQNKLELEAKKNWDLFYKRNSTNFFKDRHWTTR
EFEELIAESREGKQKSLLEVGCGVGNTVYPLLDASPEIFIHCCDFSPRAVQFVKEHSAYDPARVNAFQCD
ITCDDLTNNIAASSVDMVTMFFVLSAIHPDKMLQSIQNIYKALCPGGLVLFRDYGLHDHAMLRFSKGHKL
SENFYVRQDGTRAFYFSTDVLSDLFIKAGFDVVVNEYVYRETVNKKEGLSVPRVFVQSKFSKKIAENS

>Caenorhabditis elegans_(Y53F4B.42)
MKDEPIMACAEENPDEKPKCNPFGTRFLTDDTKVFEHNAWDDVEWSPEQQEEAQRIVQGQ
KSMKVDEEKAMRLLSTPADQWDAFYAHNENRFFKDRNWLLKEFPELNVEDESNLQKEKIE
ILEVGCGVGNTTFPLLQVNNSSSRLMLHSCDYAPNAIRVLKSQDAYDPEKMNAFVWDITQ
PASQEAPNVGSLDYIVCIYVLSAIHPDNIKNALKNLVRLLKPGGSLLLKDYGRYDLTQLR
FKKDRLIDGNLYCRGDGTLVYFFDMEELETLLAEHGLQKKVMHVDRRLIVNRAKQVKMYR
QWIQGKFLKSC

>Nematostella vectensis_(XP_01637965)
MAEGKDIRDIQNETESSIQGLYPRVLTDEEKQKLERDTSCISEFKRNKLEQDARKNWDLFYKRNSTNFFK
DRRWTTREFTELLNVEDEKLNEKVLLEAGCGVGNLINPLLEEGYNFYFHACDFSPRAVNFVKESPFYDEA
KVNAFQCDLTKDDLLENIPACSVDIATLIFVLSAIHPDKMITALLNIFKVLKPGGLLLLRDYGLYDHAML
RFAPGHKLSEQFYVRQDGTRAFYFSQDDLEVLFKKAGFVVLMNKYVEKRTVNKKENIDVPRIFVQGKFMK
PES

>Hydra magnipapillata_(XP_02156347)
MIFENEVYGFSTKDDQILSEVELKKLACDRNLVSNYKQIQLEINAQKNWDLFYKRNSTKFFKDRHWTTRE
FDEITSEKLNDKKLLEVGCGCGNAIFPLIEENKNIFVYACDFSSRAIEYVKAHKLYELSRCLAFQSDVTK
DNLCSFVPEASIDIALMIFVLSAVHPDKMKEVLQNVHRVLKPGGIVLFRDYGLYDHAMLRFGPGHKLDDR
FYVRQDGTRAYYFSTDKLFELFTSCGYEVVENTYIHRRTINKKEGIDVPRIFVQGKFTKLS

>Hydra magnipapillata_(XP_0216525)
MDIVTTGVANGKSKQRVVLGESVSSWVDIVSGVPQGSVLGPILFLIYINDLLSQLTNQLLLYADDCKVIA
LSRLSKMQTVNCPAIEEGYSDSSGVADKQIQLEINAQKNWDLFYKRNSTKFFKDRHWTTREFDEITSQKL
NDKKLLEVGCGCGNAIFPLIEENKNIFVYACDFSSRAIEYVKAHKLYELSRCLAFQSDVTKDNLCSFVPE
ASIDIALMIFVLSAVHPGKMKEVLQNVHRVLKPGGIVLFRDYGLYDHAMLRFGPGHKLDDRFYVRQDGTR
AYYFSTDKLFELFTSCGYEVVENTYIHRRTINKKEGIDVPRIFVQGKFTKLS