>Homo sapiens_FZD1(ENSP_287934)
MAEEEAPKKSRAAGGGASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLW
LLEAPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSGQQYNGERGISVPDHGYCQPIS
IPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVL
EQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTP
SLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRALKVPSYLNYHFLGEKDCGAPC
EPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSG
CYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWW
VILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVG
LNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVF
SVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQAGGGAPPHPPMSPDF
TVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
>Gorilla gorilla_FZD1(ENSGGOP_431)\t
GRRRPPVDPRRLARQLLLLLWLLETPLLLGVRAQAAGQGPGQGPGPGQQPPPPPQQQQSG
QQYNGERGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKV
QCSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFP
VHGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASERGKFSCPRA
LKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVL
TYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKK
EGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKT
ITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTI
MKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCKSYAI
PCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTN
SKQGETTV
>Mus musculus_FZD1(ENSMUSP_58629)
MAEEAAPSESRAAGRLSLELCAEALPGRREEVGHEDTASHRRPRADPRRWASGLLLLLWL
LEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQSGQQYNGERGISIPDHGYCQPISIPLCT
DIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALP
PCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPE
FWTSNPQHGGGGYRGGYPGGAGTVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKV
YGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAV
AVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSL
TWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVD
ALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYT
VPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMI
KYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
>Rattus norvegicus_FZD1(ENSRNOP_21979)\t
MAEEAVPSESRAAGRPSLELCAVALPGRREEVGHQDTAGHRRPRADSRCWARGLLLLLWL
LEAPLLLGVRAQAAGQVSGPGQQAPPPPQPQQGGQQYNGERGISIPDHGYCQPISIPLCT
DIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQALP
PCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCVGQNTSDKGTPTPSLLPE
FWTSNPQHGGGGYRGGYPGGAGPVERGKFSCPRALRVPSYLNYHFLGEKDCGAPCEPTKV
YGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAV
AVAYIAGFLLEDRVVCNDKFAEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSL
TWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVD
ALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYT
VPATIVIACYFYEQAFRDQWERSWVAQSCKSYAIPCPHLQGGGGVPPHPPMSPDFTVFMI
KYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
>Gallus gallus_FZD1(ENSGALP_14736)
MAERRGPAGGGSGEVGGGRRAGGDRCPRRPPALPLLLLLWAAALPAGGQPAAQPAALSER
GISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELK
FFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLRCEKFPVHGAGEL
CVGQNASERGTPTPALRPESWTSNPQRGGGAGGSGPGEARGRFSCPRALKVPSYLNYRFL
GEKDCGAPCEPGRLYGLMYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYP
ERPIIFLSGCYTAVAVAYIAGFLLEERVVCNERFAEDGSRTVAQGTKREGCTILFMMLYF
FGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGD
VLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLE
KLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWERSWVTQSCKSYAIPCPNNHSSHHPP
MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
>Taeniopygia guttata_FZD1(ENSTGUP_2231)
MGPPGLLPALAWLLAWLSVPAPSRAQLHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMP
NLLGHTNQEDAGLEVHQFYPLVKVQCSLELKFFLCSMYAPVCTVLEQAIPPCRSICERAR
QGCEALMNKFGFQWPERLRCENFPRHGAEQICVGQNHSEDGSSPALLTSATPLAGQGTPG
APRYATLDHPFHCPRALKVPSYLNYKFLGEKDCAAPCEPTRPDGHMFFNEDEIRFARIWI
LIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLEERVVCNE
RFQEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEAN
SQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGT
SFLLAGFVSLFRIRTIMKHGGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFRE
HWERSWISQNCKSLAIPCPLHFTPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSW
RKFYTRLTNSKQGETTV
>Homo sapiens_FZD2(ENSP_323901)
MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNL
LGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQG
CEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTP
GGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEE
TRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVL
QERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKW
GHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPL
FVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACY
FYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIW
SGKTLHSWRKFYTRLTNSRHGETTV
>Mus musculus_FZD2(ENSMUSP_91463)
MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQT
IMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICE
RARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPG
AGGTPGGPGGGGSPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMF
FSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYI
AGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLA
AGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGF
VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATI
VIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITS
GFWIWSGKTLHSWRKFYTRLTNSRHGETTV
>Rattus norvegicus_FZD2(ENSRNOP_36154)
MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQT
IMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICE
RARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGTPALLTTAPPSGLQPG
AGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMF
FSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYI
AGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLA
AGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGF
VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATI
VIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITS
GFWIWSGKTLHSWRKFYTRLTNSRHGETTV
>Gallus gallus_FZD2(ENSGALP_34947)
VPDHGFCYPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSLELKFFL
CSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCENFPRHGAEQICVG
QNHSEDGGSSAALLTSAAPPAAHGTPGAPRYATPDRPFHCPRALKVPGYLNYKFLGEKDC
AAPCEPSRPDGHMFFNEDEIRFARVWILVWSVLCCASTFFTVTTYLVDMQRFRYPERPII
FLSGCYTMVSVAYIAGFVLEERVVCNERFQEDGYRTVVQGTKKEGCTILFMMLYFFSMAS
SIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGV
CFVGLNGIDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHGGTKTEKLERLMVR
IGVFSVLYTVPATIVIACYFYEQAFRQHWERSWISQHCKSLAIPCPLHFTPRMTPDFTVY
MIKYLMTLIVGITSGFWIWSGK
\t
>Anolis carolinensis_FZD2(ENSACAP_12274)
MRLHHDASLARSPLVFFFLLLLLCSCWAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQT
IMPNLLGHTSQEDAGLEVHQFYPLVKVQCSPELKFFLCSMYAPVCTVLEQAIPPCRSICE
RARQGCEALMNKFGFQWPERLRCENFPRHGTEQICVGQNHSEEGASPALVTSATPIAGHG
TVGPPRYATLDHPFHCPRVLKVPTYLNYKFLGEKDCAAPCEPAKSDGHMFFNQEEIRFAR
IWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLEERVV
CNERFQDDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAI
EANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLF
IGTSFLLAGFVSLFRIRTIMKHGGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQA
FREHWERSWISQNCKSLAIPCPLQYTPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTL
HSWRKFYTRLTNSKHGETTV
>Xenopus tropicalis_FZD2(ENSXETP_19419)
FSASAMQGVTRSSNLIVCHLFALCLLSFAQLHGEKGISVPEHGFCQPISIPLCTDIAYNQ
TIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSSELRFFLCSMYAPVCTVLEQAIPPCRSIC
ERARHGCEALMNKFGFQWPERLRCENFPRHGAEQICVGQNHSEDGGPTLLTTSPPHHGTP
GPPIYATLDHPFHCPRVLKVPSYLNYRFLGEKDCAAPCEPSKNDGFMFFSQDEIRFARVW
ILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLGDKVVCN
ENFSEDGYKTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEA
NSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIG
TSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFR
EHWERSWVSQNCKSLAIPCPLQYTPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHS
WRKFYTRLTNNKHGETTV
>Takifugu rubripes_FZD2(ENSTRUP_38615)
LEPKRGEKKQSCLQLGKTWFVAFLLPLLVTAQYHGDNGIVPDHGFCQQISIPLCTDIAYN
QTIMPNLVGHYNQEDAGLEVHQFYPLVKVQCSPELKFFLCSMYAPVCTVLEKAIPPCRSI
CERAKQGCEALMNKFGFQWPEPLRCENFPVQGDEQICVGQNDSTAATVPPILPGPGTSDL
PFPGNGPFRCPPALKVPPHLNYKFLDEKDCAAPCEPSRRGGSMFFTDKEIHFSRVWILVW
SVLCCASTLFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSIAYIAGYFLGDAVVCNEGFT
PENYKTLVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQY
FHLAAWAVPAVKTISILAMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFL
LAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFRAHWE
RSWFSHNCRAFDICPTQTGPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWHKFY
TRLTYGKHGETTV
>Tetraodon nigroviridis_FZD2(ENSTRUP_38615)
IIYLKMGYCCGLDKTWIVAFLLPLLVTAQYHGDNGIVVPDHGFCQQITIPLCTDIAYNQT
IMPNLVGHYNQEDAGLEVHQFYPLVKVQCSPELKFFLCSMYAPVCTVLEKAIPPCRSICE
RAKQGCEALMNKFGFQWPERLRCENFPVQGDEQICVGQNDSTAATVPPILPGRGTEVPFP
PSGPFRCPPALRVPPHLNYKFLDEKDCAAPCEPSKRGGSMFFTDKEIHFSRIWILVWSVL
CAFTLFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSIAYIAGYFLGDTVVCNDSFSPENY
KTLVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLA
AWAVPAVKTISILMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFLLAGFV
SLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFRTHWERSWFS
QNCRAFAIPCPTHTGTRTTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWHKFYTRLT
YGKHGETTV
>Gasterosteus aculeatus_FZD2(ENSTNIP_14649)
ETHFRCPPVLKVPPYLNYKFLEVKDCAAPCEPARSGGYMFFSDKEIRFSRIWILVWSVLC
CASTLFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGYFLGDKVVCNDSFSPERY
KTIVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEAHSQYFHLA
AWAVPAVKTISILAIGQIEGDVLSGVCFVSLGSLYPLRGFVLAPLFIYLFIGTSFLLAGF
VSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACVFYEQAFRPHWERSWV
SHNCRGLAIPCPSQTGPRMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWHKFYTRL
TNGKQGETTV
>Oryzias latipes_FZD2(ENSORLP_5263)
RKGRRLLFRSETPRSSLWFLCLTAVISAQHQGDDGLMLPPHGFCQQISIPLCTDIAYNQT
IMPNLMGNHNQEDAGLEVHQFFPLVKVQCSPELKFFLCSMYAPVCTVLEKPIPPCRPICE
KARQGCEALMNKFGFQWPEKLRCENFPLLGDHGQICVGQNESSSPTAPPPLPPAPGTREL
PRVSTHERPFTCPSVLRVPPYLNYHFLEEKDCGAPCESPRNGGNMFFSDKEIHFARMWVL
IWSVLCCTSTFFTVTTYLIDMQRFRYPERPIIFLSGCYTMVSIAFIAGYFLGDKVACNDS
FNPDGYKTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANS
QYFHLAAWAVPAVKTISILAMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTS
FLLAGFVSLFRIRTIMKHDGTKTEKLEQLMVRIGVFSVLYTVPATIVIACFFYEQAFRPH
WERSWVSRNCRSLAIPCPAQSRPHMTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWR
KFYTRLTSGKNGETTV
>Homo sapiens_FZD3(ENSP_240093)
MAMTWIVFSLWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAAL
AMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVP
WPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFL
HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF
YAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAG
SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGV
CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR
IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILF
LMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDP
NTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPC
SYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE
EDGTSA
>Gorilla gorilla_FZD3(ENSGGOP_17505)\t
MAMTWIVFSFWPLTVFMGHIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAAL
AMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVP
WPEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFL
HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF
YAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFFTMAG
SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGV
CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR
IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILF
LMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDP
NTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSIHSKVSSYHGSLHRSRDGRYTPC
SYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE
EDGTSA
>Mus musculus_FZD3(ENSMUSP_115325)
MAVSWIVFDLWLLTVFLGQIGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAAL
AMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVP
WPEDMECSRFPDCDEPYPRLVDLNLVGDPTEGAPVAVQRDYGFWCPRELKIDPDLGYSFL
HVRDCSPPCPNMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIF
YAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAG
SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGV
CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR
IGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPDLILF
LMKYLMALIVGIPSIFWVGSKKTCFEWASFFHGRRKKEIVNESRQVLQEPDFAQSLLRDP
NTPIIRKSRGTSTQGTSTHASSTQLAMVDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPC
SYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHITHGTSMNRVIE
EDGTSA
>Gallus gallus_FZD3(ENSGALP_26786)\t
MAVSWMFCCFWLLDVLVGCTRGHSLFSCEPIILRMCQDLPYNTTFMPNLLNHYDQQTAAL
AMEPFHPMVNLECSRDFRPFLCALYAPVCMEYGRVTLPCRRLCQRAYSECSKLMEMFGVS
WPEDMECTRFPDCDEPYPRLVDLSLGGEPTEEAPMAVQRDYGFWCPRELKIDPDLGYSFL
RVRDCSPPCPNMYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIF
YAVCYMMVSLIFFIGFLLEDRVACNASSPAQYKASTVTQGSHNKACTMLFMVLYFFTMAG
SVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIVLLAMNKIEGDNISGV
CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR
IGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQERCREYHIPCPYQVTQMSRPDLILF
LMKYLMALVVGIPSVFWVGSKKTCFEWASFFHGRRKKEVVNESRQVLQEPDFAQSLLRDP
NTPIIRKSRGTSTQGTSTHASSTQLAMLDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPC
SYRGIEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSSIRDLSSNPLTHITHGTSMNRVIE
EDGTSA
>Anolis carolinensis_FZD3(ENSACAP_10597)
MAANWVMQFIWPLAVLVGCTSGHSLFSCEPIILRMCQDLPYNSTFMPNLLNHYDQQTAAL
AMEPFHPMVNLECSREFRPFLCALYAPVCMEYGRVTLPCRRICQRAYNDCSKLMEMFGVS
WPEDMECSKFPDCDEPYPRLVDLNVVGESTEEAPVAVQRDYGFWCPRELKIDPDLGYTFL
RVRDCSPPCPNMYFRREELAFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIF
YAVCYMMVSLIFFIGFLLEDRVACNASSPTTYKASTVTQGSHNKACTMLFMVLYFFTMAG
SVWWVILTITWFLAAVPKWGSEAIEKKALLFHTSAWGIPGTLTIILLAMNKIEGDNISGV
CFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKFMIR
IGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQERCKEYHIPCPYQVTQMSRPDLILF
LMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKDVVNESRQVLQEPDFAQSLLRDP
NTPIIRKSRGTSTQGTSTHASSTQLAMMDDQRSKAGSVHSKVSSYHGSLHRSRDGRYTPC
SYRGIEDRLPHGSMSRLTDHSRHSSSHRLNDQSRHGSARDLSGNPTTHITHGTSMNRVIE
EDGTSA
>Danio rerio_FZD3(ENSDARP_108442)
MGCVVDLPWRGMWILSVVSLLSGSMAIHMDSVGSHSLFTCESIGLRMCQDLPYNNTFMPN
LLNHYDQQTAALAMEPFHPMVNLQCSPDLRPFLCALYAPVCMEYGRVSLPCRSLCHHAKR
DCQKLMDMFGVTWPEEMECTRFPDCDESYPRAEDLLVIDDPTDQSPMSVQRDYGFWCPRE
LKMEPDLGYTFLGVRDCSPPCPNMYFRREELTFARYFIGVVSIVCLSATLFTFLTFLIDV
TRFRYPERPIIFYAVCYMMVSLVFFLGFLLEDRVACNSANPGQYKTSTVTQGSHNKACTL
LFMVLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGMLTIALLA
LNKIEGDNISGVCFVGVYDVQTLRWFVLAPLCLDVLVGVSLLLAGIVALNRVRMEIPLEK
ENQEKLVKFMIRIGVFSVLYLVPLLTVVGCYLYEQTYRSVWETTWVQERCREYHIPCPFK
VEQTSRPDLVLFLIKYLMVLVVGIPSVFWVGSKKTCFEWAGFFHGRRRKDSGAVHESRQV
LQDPDFAQSLLRDPNTPIVRKSRGTSTQGTSTHASSTHLAMLDDVRSKASSVHSKSSFHS
SLQRSRDERFTSSTHRGLEERPAYGSLPRLTDQQPSRHSSTPELSHTPAVSESQQEEQEQ
PENGTSA
>Takifugu rubripes_FZD3(ENSTRUP_11956)
GCTKGCPSVCFSLLLIPISMLFFLGTPALCIHLETTESHSEFSCEPIRLRMCQDLPYNTT
FMPNLLHHYDQQTAALAMEPFHPMVNLECSPDLRMFLCALYTPVCVVYGQVSMPCRSLCQ
RAKDECHKLMEIFGVSWPDDMECRFPDCDEPYPRPEDLLTGSDPTNQSSLTVQRDYGFWC
PRELKVDTDLGYTFMGKKDCSAPCPSMFFSRQELTFIRYFIGVTSLICLSATLFTFLTFL
IDVTRFRYPERPIIFYAACYVMVSLVFFLGFLLEDRVACNAASPAHFRAATITQGSHNKV
CTLFFMVLYFFAMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVA
LLALNKIEGDGISGVCFIGLYDIDALRWFVLAPLGLNVTVGVSLLFVGIVALNKVRMEIP
LEKENQTKLVKFMIRMGVFSALYVVPLLVVIGCYLYEHTYRSIWETTWMEENCRHYHIPC
PYKVKQISHPAAVLFLMKYLMMLVVGIPSVFWVGSKKTCFEWANFLQGRRRKDSGVNESR
QVLQEQPDFAQSLLREPNTPVIRKSRGTSTQGTSTHASSTNLAALDGLDDPVQTHQRHAA
STRNKASSVHSKASYHGSLRRTREDRYSSKSDTVVYRGAGECSFHGSLSRLNHPLSTHSS
LHQLDGHSRHNSQQDVTEVPPALIRHGTTA
>Tetraodon nigroviridis_FZD3(ENSTNIP_3533)
IPVYILFFLGAPAAGIRMESTESHSEFSCEPIRLRMCQDLPYNTTFMPNLLNHYDQQTAA
LAMLPQPFHPMVNLECSPDLRMFLCALYAPVCVVYGQVSMPCRSLCQRAKNQCHKLMEIF
GVAWPEDMECSIWFPDCDEPYPRPEDLLTGSDPANQSSMTVQREYGFWCPRELKVEADLG
YSFMGRRDCSAPCPSMFFHPQELTLIRYFIGVTSVVCLSATLFTFLTFLIDVTRFRYPER
PIIFYAVCYVMVSLVFFLGFLLEDRVACNAASPAHFRAATVTQGSHNKVCTLFFMVLYFF
TMAGSLWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVALLALNKIEGDG
ISGVCFIGLYDIDALRWFVLAPLGLNVTVGVSLLFVGIVALNKVRMEIPLEKENQTKLVK
FMIRMGVFSALYLVPLLVVLGCYLYEHTFRSVWERTWMEENCRRYHIPCPYEVKQTGRPA
AVLFLMKYLMMLVVGIPSVFWVGSKKTCFEWADFMQGRRRKDSGVNESRQVLQEQPDFAQ
SLLREPNTPIIRKSRGTSTQGTSTHASSTNLAVMDGLEDPAPAHQRHAASTRSKASSVHS
KASCHGSLRRPREDRGDTVVYRGTEERGFHGSLSRLNRPLSAHSSLHQLDGQSRRNSQQD
APEVPPALITHGTTASHSQAGAGADTSA
>Gasterosteus aculeatus_FZD3(ENSGACP_21441)
LLVPFVLLLFSVVTPAVSIHMDSMESHSEFSCEPIRLRMCQDLPYNTTFMPNLLNHYDQQ
TAALAMEPFHPIVNLVCSADLRMFLCALYAPVCTVYGQVSLPCRSLCQQAKDECHKLMEV
FGLDWLDDMECNRFPDCDEPYPRPEDLLTGTDTTDQSSMTVQRDYGFWCPRELKIDPDLG
YTFMGKKDCSAPCPSMFFSKQELNFIRYFIGVVSIVCLSATLFTFLTFLIDVTRFRYPER
PIIFYAVCYVMVSLVFFLGFLLEDRVACNAVSPSQFRAPTITQGSHNKVCTLFFMVLYFF
TMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGVPGALTVTLLALNKIEGDG
ISGVCFIGLYDIDALRWFVLAPLCLNVAVGVTLLLVGIVALNRVRMEIPLEKENQTKLVK
FMIRMAVFSVLYLVPLLTVIGCYLYEHTYRNNWETTWMEENCKRYHIPCPYKVEQTRRPA
MVVFLVKYLMMLVVGVPSVFWVGSKKTCFEWASFLQGRRRKDSGVNESRQVLQEQPDFAQ
SLLREPNTPIVRKSRGTSTQGTSTHASSTHLADLDEPVTTHHGNPTSTRSKASSVHSKGS
YHGSLRRIRDDRSDTVACRGTEQRSFHGSMPRLDHPLSAHSSLHQIDGSRHGSQRNICEA
PSTLITHGTTGGESQASEKDGTSA
>Oryzias latipes_FZD3a(ENSORLP_20010)
MDALWVLSLSMLTACVAIPMDAAAGSHSLFTCEPITLRMCQELPYNATFMPNIMNHYDQQ
TAALAMEPFHPMVNLRCSPDLRMFLCALYAPVCTEYGRMTLPCRRLCLQAKSDCYKLMEM
FGVSWPDEMDCIRFPDCDDPYPRPADLLSSSDTTESPISVQRDYGFWCPRELKISPELGY
SFMGVRDCSPPCPNMYFTREELAFARYFIGVVSIVCLSATLFTFLTFLIDVARFRYPERP
IIFYAVCYMMVSLVFFLGFLLENKVSCNTASPGKFRASTVTQGSHNKACTLLFMVLYFFT
MAGSIWWVILTITWFLAAVPKWGSEAIEKKALLFHACAWGVPGILTVTLLAMNKIEGDGM
SGVCFVGLYDLTALRWFLLAPLGLDVVVGVVLLLAGIAALNRVRMEIPLEKENREKLVKF
MIRIGVFSVLYLVPLLTVLACYLYESSYRALWETSWVQRECRRYHIPCPYQVERTSHPDL
VLFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFNGKRRKQMVNDSRQVLQEPDFAQLLY
RDPNTPIVRKSRGTSTQGTSTHASSTHLAMLDEPPSGSTSRAGSVRSARSKMSSYHGSLH
RSRDGRYTGSSFRAPNDRPPFGSLPRLNAQSRHCSTNRLDSLSRHGSTLRLESQSQHSSI
RDLSPATQAVLSGNGIRRVMEEDGA
>Oryzias latipes_FZD3b(ENSORLP_14222)
IPLFLVLFSLPSPALSINMEPIESHSEFSCEPIRLRMCQDLPYNTTFMPNLLNHYDQQTA
ALAMEAFNTLVNLVLFKPFRPPLFSTSPPSEIEQIRASLPHSLCRQTTLHSHSEKSRLRE
KFESMWHHGLRFWLFVFRFPDCNEPYPRPEDLLTDSEPTGQSSMTVQRDYGFWCPRELKV
DPDLGYTFMGRKDCSAPCPSMFFNQDELMFTRHFIGAISILCLSATLFTFLTFLIDVTRF
RYPERPIIFYAVCYVMVSLIFFLGFLLEDRVACNSVSPAQFRAPTITQGSHNKACTLFFM
VLYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGLPGALTVTILALNK
IEGDGISGVCFIGLYDIHALRWFVLAPLCFNVVVGIFLLLVGIIALNRVRMEIPLEKENQ
AKLVKFMIRMGVFSVLYLIPLLTVIGCYFYEHTYRSIWETTWMEENCRRYHIPCPYKVEE
TSRPRMALFLIKYVMMLVVGIPSVFWVGSKKTCFEWAGFLHGRRRKDSGVNESCQVLQEQ
PDFAQSLLREPNTPIIRKSRGTSTQGTSTHASSTHLAALDDLDEPIITHHRHAVSTRSKG
GSVHSKASYHGSLHRTRDERFQSNSVAHSGTQDRSFHGSMPRLDHPLSTHSSLHQIDTHS
RRSSHPDLSEAPPTLITHGTTGSDGKVAEDGTSA
>Homo sapiens_FZD4(ENSP_434034)
MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNV
TKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGM
CLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE
CHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLT
FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT
GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI
VILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNL
QKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLK
IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
>Gorilla gorilla_FZD4(ENSGGOP_14391)
KGGGPRSTESPGLISFRIPLWNFISYRLKATIGGFGDEEERRCDPIRISMCQNLGYNVTK
MPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCL
SVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECH
SVGINSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFL
IDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGC
AIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVI
LIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQK
DGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIF
MSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV
>Mus musculus_FZD4(ENSMUSP_49852)
MAWPGTGPSSRGAPGGVGLRLGLLLQFLLLLRPTLGFGDEEERRCDPIRIAMCQNLGYNV
TKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGM
CLSVKRRCEPVLREFGFAWPDTLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE
CHSVGSNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLT
FLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNT
GCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTI
VILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNL
QKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLK
IFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV
>Rattus norvegicus_FZD4(ENSRNOP_23205)
MAWQGTGPSVRGMPGGVRLRLGLLLLQLLLLQRPALGFGDEEERRCDPIRIAMCQNLGYN
VTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGG
MCLSVKRRCEPVLKEFGFAWPDSLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGE
ECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVL
TFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKN
TGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKT
IVILIMRLVDADELTGLCYVGNQSLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSN
LQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEML
KIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV
>Gallus gallus_FZD4(ENSGALP_27820)
MERRGGGGRMLALLLAGLLGGARGFGDEEERRCDAIRIAMCQNLGYNVTKMPNLVGHELQ
ADAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVL
KEFGFAWPDSLNCSKFPPQNDHNHMCMEGPGDEEVPLHSKTSLQPGEECHSMGSNSDQYI
WVKRNLDCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPE
RPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFF
GMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADE
LTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLER
LMVKIGVFSVLYTVPATCVIACYFYEISNWAVFRYSADDSNMAVEMLKIFMSLLVGITSG
MWIWSAKTLHTWQKCSNRLVNSGKVKREKRADGWVKPGKGNETVV
>Taeniopygia guttata_FZD4(ENSTGUP_13301)
SLFQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFVWPDSLNCSKFPPQ
NDHNHMCMEGPGDEEVPLHSKTSLQPGEECHGMGSNSDQYIWVKRSLSCVLKCGYDAGLY
SRSAKEFTDIWMAIWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIV
RLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFV
VAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCV
IACYFYEISNWAIFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRL
VNSGKVKREKRADGWVKPGKGNETVV
>Anolis carolinensis_FZD4(ENSACAP_2633)
KADGGAGGWAMAPGGRLLLGLLWAALVSGEGARGFGDEEERRCDPIRIPMCQNLGYNVTK
MPNLVGHDLQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKIDIPIGSCGGMCL
SVKRRCEPVLKEFGFSWPESLNCSKFPPQNDHNHMCMEGPGDEEVPIHSKTPLHPGEECH
SVGANSDQYIWVKRSLNCVLKCGYDAGLYSRSAKAFTDIWMAVWASLCFISTAFTVLTFL
IDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGC
AIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVI
LIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQK
DGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWTIFRYSADDSNMAVEMLKIF
MCLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGRVKRGEKRANGWVKPGKGNETVV
>Xenopus tropicalis_FZD4(ENSXETP_22901)
MGVRALALCLPLLGCLVGHIAGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQAD
AELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKE
FGFAWPESLNCSKFPPQNDHNHMCMEGPGDDEVPVHSKTPVLPGEDCNSFGPNSDQYTWV
KRSMNCVLKCGYDSGLYSRLSKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFCYPERP
IIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGM
ASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELT
GLCYVGNQNIDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLM
VKIGVFSVLYTVPATCVIACYFYEISNWNVFRYTADDSNMAVEMLNIFMSLLVGITSGMW
IWSAKTLHTWQKCTNRLVNSGKVKRKKRVDGWVKPGKGNETVV
>Takifugu rubripes_FZD4(ENSTRUP_15491)
MERRRWGESSLLLLLSGLLAALCAVKAFGEELEEMTCDPIRISMCQGLGYNVTKMPNLVG
NVLQSDAELQLTTFTPLIQYGCSSQLKFFLCSVYVPMCTVKIPIPIGPCSSMCLSVKKKC
FPVLQEFGFIWPEELNCSLFPPQNDHNHMCMEGPGDEDLPYPPLWNPHHQQECHALGSGP
DQYIWLKQTESCTLQCGYDSGLYRRGTKVFTDAWMAVWAVLCFLSTTLTVLTFVLDSQRF
SYPERPIIFLSMCCNLYSVAYLVRWTLGREHVSCDLEATAVPVLVQEGLKSTGCAIVFLL
LYFFGMASSLWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLV
DADDLTGLCYVGNQQQEALIGFVVAPLATYLLLGTLFICAGLVALFRIRSNLQKDGAKTD
KLERLMVKIGVFSVLYTVPASTVIGCYIYQLAHWGEFNTIPQDSYVASEMLRIFMSLLVG
ITSGMWIWSAKTLHTWQRCSTRLVRDSRASRSGQRAPCTGWIKPGKGNETVV
\t
>Gasterosteus aculeatus_FZD4(ENSGACP_10666)
MPGILRSFGGAALLVLSALLGALREVEAFGDEVEEMTCDPIRISMCQGLGYNVTKMPNLV
GNVLQSDAELQLTTFTPLIQYGCSSQLKFFLCSVYVPMCTDKVPIPIGPCGSMCLSVKRK
CLPVLHEFGFIWPEVLNCSLFPPQNDHNHMCMEGPGDEDPPYQPVRHPPQQEDCQALGSA
PDQYTWLKQSESCALQCGYDSGLYRRGAKVFTDAWMAVWAVLCFLSTTLTVLTFLLDSQR
FSYPERPIIFLSMCCNLYSVAYLVRLTLGRERVSCDLDATAVPILVQEGLKSTGCAIVFL
LLYFFGMASSLWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRL
VDADDLTGLCYVGNQQQEALTGFVVAPLATYLLIGTLFICAGLVALFKIRSNLQKDGAKT
DKLERLMVKIGVFSVLYTVPASTVIGCYLYQLSHWGEFRASTQDSYVASEMLRIFMSLLV
GITSGMWIWSAKTLHTWQRCTARLLRDSRASRGGKRAPGEGWIKPGKGNETVV
>Oryzias latipes_FZD4(ENSORLP_13516)
WPRVGPGNPTPAPGLVRLSAGALLLLLRALCAVNAFGDEMEEMTCDPIRISMCQGLGYNV
TKMPNLVGNMLQSDAELQLTTFTPLIQCGCSSQLKFFLCSVYVPMCTDKVPIPIGPCGSM
CLSVKRKCLPVLLEFGYTWPEALNCSRFPPQNDHNHMCMEGPGDEDPPYQSVHHPSDQDC
QALDSTPDQYTWLKQTESCVLQCGYDNGLYRRGAKVFTDAWMAVWAVLCFLSTTLTVLTF
LLDSQRFSYPERPIIFLSMCCNLYSVAYLVRLTLGRERVSCDLDAVGVPVLVQEGLKSTG
CAIVFLLLYFFGMASSLWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAAKTIV
ILIMRLVDADDLTGLCYVGNQQQEALTGFVVAPLATYLLVGTLFICAGLMALFKIRSNLQ
KDGTKTDKLERLMVKIGVFSILYTVPASTVIGCYLYQLSHWGEFKTSTHDSYVTSEMLRI
FMSLLVGITSGMWIWSAKTLHTWQRCSSRLLREGHVGRGGKSAPGEGWIKPGKGNETVV
>Homo sapiens_FZD5(ENSP_354607)
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQ
DEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLM
RQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGG
ECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIG
LWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSR
EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYF
HLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLL
AGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA
ALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCR
PRRGHKSGGAMAAGDYPEASAALTGRTGPPGPAATYHKQVSLSHV
>Gorilla gorilla_FZD5(ENSGGOP_5802)
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQ
DEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLM
RQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGG
ECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIG
LWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSR
EHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYF
HLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLL
AGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA
ALTCACPGHDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCR
PRRGHKSGGAMAAGDYPEASAALTGRTGPPGPSATYHKQVSLSHV
>Mus musculus_FZD5(ENSMUSP_67783)
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQ
DEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLM
RQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGG
ECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIG
LWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSR
EHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYF
HLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLL
AGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA
ALTCACPGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCCCS
SRRGHKSGGAMAAGDYAEASAALTGRTGPPGPTAAYHKQVSLSHV
>Rattus norvegicus_FZD5(ENSRNOP_62259)
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQ
DEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLM
RQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGG
ECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIG
LWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSR
EHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYF
HLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLL
AGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEA
ALTCACPGSDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCCCS
SRRGHKSGGAMVAGDYAEASAALTGRTGPPGPAAAYHKQVSLSHV
>Gallus gallus_FZD5(ENSGALP_11424)
LYFFGMASSIWWVFLSLTWFLAAGMKWGNEAIASYAQYFHLAAWLIPSAKSITVLALSSV
DGDPVAGVCYVGNQSLENLRGFVLAPLVVYLFTGSLFLLAGFVSLFRIRSVIKQGGTKTD
KLEKLMIRIGIFTVLYTVPATIVIACYIYEQHNREAWEQAQNCSCPGDPHRPKPDYAVFM
LKYFMCLVVGITSGVWIWSGKTLESWRRFTARCCRPKKPAGAAAYGEASPALVGRTVLPS
MASYHKQVPLSHV
>Anolis carolinensis_FZD5(ENSACAP_9583)
PLPPPPAPPPRRPFLLLAHIQERARASSSSKAVTCQEITVPMCKGIGYNLTYMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSPDLKFFLCAMYTPICLLDYAKPLPPCRSVCERAKAGCSP
LMRQYGFAWPERMGCDKLPLLGDAEQLCMDYNRTEAAPASATTTFPPIGTKPTRSKAKGG
YKEKAPFDSSSGTCKRVCECREPLVPISKETHPLYNKIETGHVRNCAIPCFQPYFTQHEK
TFATFWIGLWSVLCFVATFATVATFLIDMERFRYPERPIIFLSACYLFVSIGYIIRLVVG
HANVACNKDYNHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEA
IASYSQYFHMAAWLIPSIKSIAVLALSSVDGDPVAGICYVGNQNLDKLRGFVLAPLVVYL
FTGTMFLLAGIVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIVVGCYIYEQ
HYRETWEMAQNCSCPGDKNRLRPDYAVFMLKYFMCLVVGITSGVWIWSGKTFESWKRFTG
RCCRSGKPVSSAMYGEATAALTGRSGMPSSASYHKQVPLSHV
>Danio rerio_FZD5b(ENSDARP_36600)
MRKPADEHHFTMETSGMHLVGFWLHVLLLFQLSGLGDSASKDIVCEPITVPMCKGIGYNH
TYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLCSMYTPICLQDYKKPLPPCRSV
CERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDTDRLCMDRNSSETTTLSPPFPKPTPKG
TPRHRATAKSAPPQKCDRECHCRGPLVPIKKEAHPLHNRVNTGSLPNCALPCHQPYFSQD
ERTFTTFWIGLWSVLCFVSTFTTVATFLIDMERFKYPERPIIFLAACYLFVSLGYIVRLL
AGHERVACEGTGDQQHILYDTTGPALCTLVFLLIYFFGMASSIWWVVLSFTWFLAAGMKW
GNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLEGLRGFVLAPL
VVYLFTGSLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGLFTVLYTVPATIVVACL
VYEQHYRPSWERALACSCPSERQRLGMGPDYAVFMLKYFMCLVVGITSGVWIWSGKTLES
WRRFIARYVPCRTRKPPVSASSMYSEASTALTARAGTAPTGTYHKSAPSSHV
>Takifugu rubripes_FZD5(ENSTRUP_37421)
EKKPTDDYIQYELYVKMIHCVASTTAVLLLLVPGLTFGASKDLVCEPITVPMCKDIGYNL
TYMPNQFNHDTQEEVGLEVHQFWPLVRIRCSPDLLFFLCSMYTPICLPDYRKPLPPCRSV
CERAKQGCSPLMSQYGFEWPERMSCEKLPQLGDEVLCMDQNNTESTTLASTFPKPTPKVQ
TRTLSPHQCDRECRCRAPLVPIKRESLTSYHHTHAGPVPNCAQPCHQPFFSADERAFTSL
WIGLWSLLCFISTLTTVATFLIDMERFQYPERPIIFLAGCYLFVSLGYIIRLVAGHEQVA
CGSSSSVHEDQLYLLYDTTGPALCTLVFLLVYFFGMASSIWWVVLSFTWFLAAGLKWGSE
AIAGYAQYFHLAAWLIPSLKTIIILAMSSVDADPVAGICYVGNQSLESLRGFVLAPLVVY
LFTGSFFLLAGFISLFRIRSIIKQGGTKTDKLERLMIRIGLFTVLYTVPATVVVACLVYE
QHYRPGWEETLACSCLTEQQLLGMGPDYAIFMLKYFMCLVVGITSGVWIWSGKTLESWRR
FVAHCCPCWLQTATAPPSMYSEASTALTGHTGTGLTAGFYHKSVSSHI
>Gasterosteus aculeatus_FZD5(ENSGACP_2743)
TAAAPRLLVLLLLFRCPGLTSAASKDLVCEPITVPMCRGIGYNLTYMPNQFNHDTQEEVG
LEVHQFWPLVRIRCSPDLLFFLCSMYTPICLPDYRKPLPPCRSVCERAKRGCSPLMSQYG
FEWPERMSCEQLPQLGDETLCMDQNSSEATTPAPPFPKPTPKGRTRPPSPPLCDRECRCR
DPLVPIKRESHTLYGQVHTGPLPNCAQPCHQAYFSADERAFTTFWVGLWSVLCFISTLTT
VATFLIDMERFKYPERPIIFLAACYLFVSLGYIIRLVAGHERVACGASGSVAGDQLHVLY
DTTGPALCTLVFLLVYFFGMASSIWWVVLSFTWFLAAGMKWGSEAIAGYSQYFHLAAWLI
PSVKTIVVLALGSVDGDPVAGICYVGNQSLENLRGFVLAPLVVYLFTGSLFLLAGFVSLF
RIRSIIKQGGTKTDKLERLMIRIGLFTVLYTVPATIVVACLVYEQHHRPGWERALACSCP
SERQRAGVGPDYAVFMLKYLMCLVVGITSGVWIWSGKTVESWRRFVARCCPCWPQKATAP
PSMYSEASSALTGHTGTGLTSGLYHKAAPSRI
>Homo sapiens_FZD6(ENSP_351605)
MEMFTFLLTCIFLPLLRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH
FLPLANLECSPNIETFLCKAFVPTCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEE
LECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQ
CAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC
YSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW
VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVG
LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF
SGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKY
LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHK
KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV
KADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITD
TGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT
>Gorilla gorilla_FZD6(ENSGGOP_15381)
MEMFTFLLTCIFLPLVRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEH
FLPLANLECSPNIETFLCKAFVPTCTEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEE
LECDRLQYCDETVPVTFDPHTEFLGPQKKTEQVQRDIGFWCPRHLKTSGGQGYKFLGIDQ
CAPPCPNMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC
YSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWW
VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVG
LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF
SGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPELALFMIKY
LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHK
KKHYKPSSHKLKVISKSMGTSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREV
KADGASTPRLRKQDCGEPASPAASISRLSGEQVDRKGQAGCVSESARSEGRISPKSDITD
TGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT
>Mus musculus_FZD6(ENSMUSP_22906)
MERSPFLLACILLPLVRGHSLFTCEPITVPRCMKMTYNMTFFPNLMGHYDQGIAAVEMGH
FLHLANLECSPNIEMFLCQAFIPTCTEQIHVVLPCRKLCEKIVSDCKKLMDTFGIRWPEE
LECNRLPHCDDTVPVTSHPHTELSGPQKKSDQVPRDIGFWCPKHLRTSGDQGYRFLGIEQ
CAPPCPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC
YSIVSLMYFVGFLLGNSTACNKADEKLELGDTVVLGSKNKACSVVFMFLYFFTMAGTVWW
VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGAPGFLTVMLLAMNKVEGDNISGVCFVG
LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF
SGLYLVPLVTLLGCYVYELVNRITWEMTWFSDHCHQYRIPCPYQANPKARPELALFMIKY
LMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDPISESRRVLQESCEFFLKHNSKVKHK
KKHGAPGPHRLKVISKSMGTSTGATTNHGTSAMAIADHDYLGQETSTEVHTSPEASVKEG
RADRANTPSAKDRDCGESAGPSSKLSGNRNGRESRAGGLKERSNGSEGAPSEGRVSPKSS
VPETGLIDCSTSQAASSPEPTSLKGSTSLPVHSASRARKEQGAGSHSDA
>Rattus norvegicus_FZD6(ENSRNOP_6195)
MEASPFLSACILLPLIRGHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQGIAAVEMEH
FLPLANLECSPNIEMFLCQAFVPTCTEQIDVVSPCRKLCEKILSDCQKLMDTFGIRWPEE
LECHRLPYCDGAVPVTSDPHTELFGPQKKTDQVPRDIGFWCPKHLRTSGDQGYRFLGIDQ
CAPPCPNMYFKSDELDFAKSFIGIVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVC
YSIVSLMYFVGFLLGNSTACNKADEKLELGNTVVLGSKNKACSVVFMFLYFFTMAGTVWW
VILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVG
LYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF
SGLYLVPLVTLLGCYVYELVNRVTWEMTWFSDHCHQYRIPCPYQANPKARPELALFMIKY
LMTLIVGISAVFWVGSKKTCTEWAGFCKRNRKRDPISESRRVLQESCEFFLKHNSKVRHK
KKHGKPGSHKLKVISKSMGTSTGVTTDHGTSAVAIADHDYLGQETSAEVQTSPEASLKEG
RADRANTPRAKGPDCGEPASTAASNSKFSGDQIDRKSRAGSVKEKSSVSEGAPSEGRVSP
KGVPGTGLMECTLQIPSSPEPNSLKGSTSLLVRSASGTRKEQGAGGHSDT
>Gallus gallus_FZD6(ENSGALP_25843)
MGVLAFFVPYSFLLTVVRGHSLFTCEPITISRCSRMPYNMTFFPNIMGHYDQDTAALQME
PFLTLMNLHCSPDVHTFLCKAFVPACLEQVHVIHPCRNLCEKVYSDCKQLIDTFGITWPE
ELECSRLVNCDETAPATAPVTTNAHGTQKTPGQTRRDYGFWCPRHLHTSNGQGYKFLGID
QCAPPCPNMYFKNYELDVAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSV
CYSIVSLMYFIGFLLGNRTACNKADDKLEIGETVVLGSQNKACTVLFMVLYFFMAGTIWW
VILTITWFLAAGRKWSCEAIAQKAMWFHAVAWGIPGFLTIMLLAMNKVEGDNISGVCFVG
LYDVDASLYFVLLPLCLCVFFGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGVF
SGLYLVPLVALLGCYVYELVNRKIWETTWVFDHCDQYHIPCPYQAKALARPEIFLFLMKY
LLTLIVGISPVFWVGSKKTCSEWANFFNRNRKRDPISESRRVLQESCEFFLRHNSKVKHK
KKHYKSSSHRLKVISKSMGTSTGGTTNHGTSAVAITNHDYLSQETVAEIKTSPETSEKEM
EADGTSAQKAEEGENSGNQMLSVSKLTVDQVEKRNKADSTCDMSSLSESLKRIGEGRVSP
RNDLIESPPLQSSSSQIADVSQSGSVSLLVYSAADGRKEMDSGNSSNH
>Taeniopygia guttata_FZD6(ENSTGUP_12509)
MGALVFFATCSLLLALVQGHSLFTCEPITISRCSGMSYNMTFFPNLMGHYDQDTAARKMD
PFLILMNLHCSPDVHTFLCGAFVPACLDQIHVIHPCQSLCEKVYSDCKQLMDTFGIAWPE
ELECTRLIDCDETAPATAAVTTNVHGTQKTPSQIRRDYGFWCPRHLHTTNGQGYKFLGID
QCAPPCPNMYFKNYELDVAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSV
CYSIVSLMYFIGFLLGNRTACNEADDKLEIGETVVLGSQNKACTVLFMVLYFFTMAGTIW
WVILTITWFLAAGRKWSCEAIAQKAMWFHAVAWGIPGFLTIMLLAMNKVEGDNISGVCFV
GLYDLDASLYFVLLPLCLCVFFGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGV
FSGLYLVPLVALLGCYVYELVNRKIWETTWVFDHCDQYHIPCPYQAKALARPEIFLFLMK
YLLTLIVGISPVFWVGSKKTCSEWANFFNRNRKRDPISESRRVLQESCEFFLRHNSKVKH
KKKHYKSTSHRLKVISKSMGTSTGGTTNHGTSAVAITNHDYLSQENVAEIKSSPETSEKE
MEADGACARRAEEGENGGDQMLPSAKLTVDQLERRNKADSTCHMNTLAESIKRVGEGRIT
PKNDFSESPSLQRSCSQIPVISQSPSVSLLVYSASDTRRELDSGNSSN
>Anolis carolinensis_FZD6(ENSACAP_9201)
MTTIHLLLTWSLIFSLAHGHSLFTCEPIHIPRCTAMAYNMTFFPNIMGHYDQYTAAIHMK
PFLPLMNIECSPDVCTFLCKAFVPLCVEPARVIHPCRSLCERVYSDCKKYMDTFGITWPE
ELECNRLEDCDETAAVTPSVTTRAHGTRKTLRQPRRDYGFWCPRHLQTSRGQSYKFLGID
QCAPPCPNMYFSDHELDVATSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSV
CYSIVSLVYFLGFLLGNRIACNQIDEKLQLSATVVLGSQNKGCTIVFMALYFFTMAGTVW
WVILTVTWFLAAGRKWSCEAIEQKAMWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFV
GLYDLDTSRFFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKKFMIRIGV
FSGLYLVPLVMLLGCYIYEQVYRKIWEITWVYDHCDEFHIPCPYQVKTLARPEIFLFLMK
YLMTLIVGISPVFWVGSKKTCSEWANFFNRNRKRDPISESRRVLQESCEFFLKHNSTTKH
RKKHYKSSSHKLKVISKSMGTSTGVTTNHGTSAVAIANHDYLSQETFTEIKSCPGSSEKN
LEADGAPSQKVEEELAHSVQSGLSMGTSPKVPLEHLEKTSKADNVQNISFSESMKRAAEG
RTTPKSDFIEALPLQISHPPLDVSQAGSLKGSASLFAHSSSDSRKAQESGHSSNG
>Xenopus tropicalis_FZD6(ENSXETP_8881)
MAARLGKVLLVTLLLPLVQSHSLFTCEPITVPRCTGMNYNMTFFPNLLEHYDQDIAALRM
EPFLPLLNLHCSPEVHTFLCRAFVPECTEPKHITMPCRSLCERVYSDCKNLIETFGITWP
AELECDRMRDCNNSQSKGGGGPDDPHDALRHPEQVHRDFKFWCPQHLKTSQGSGFKFLGV
DRCAPPCPNMYFKKVDMDFAKYFIGIISIICLCVTLFTVLTFLIDVQRFRYPERPIIFYS
VCYSMVSLMYVIGFLMGNSIVCNEREENFASGDTVVLGSQHKACTIIFMLLYFCTMAGTI
WWVMLTITWFLAAGRKWSCEAIEQKSLWFHGVAWGIPGILTIILLAMNKVEGDNISGVCF
VGLYDQEVSIYFVLLPLCLCVFIGLSLLLAGIISLNNVRQVIQHDERNQQKLKKFMIRIG
VFSGTYLVPLVILLGCYVYEQVYRSSWEMTWVSDNCQDYHIPCPFQLKNPARPDLGLFIT
KYIMTLIVGISAIFWVGSKKTCSEWVNFFNRSRKQDPISESRRVLQESCEFFLKHNAKVK
HKKKKHSKSGSHKLKVISKSMGTSTSGKINHGMTAVTNTSHDFLGQEASGDVRSTLDFSR
TEDPEGASCIHKSRDDITGEVTTQTLLDGTEAPVEHTDCNNKPGSKRGNGLPGSIHTILH
ESLHEVAENRVNVESASLDPDQTEDLSKVPGHTSPHDND
>Danio rerio_FZD6(ENSDARP_84982)
MVLLWALCSMLTVCMAINMEATGSHSMFSCEPITLRMCQGLAYNTTFMPNLLNHYDQQTA
ALAMEPFHPMVNLECSTEIRPFLCALYAPVCTEYGRVTLPCRRLCQRAKSDCYKLMEMFG
VSWPDEMECSRFPECEESYPRAIDLLPSSDSTEESPSAVQRDYGFWCPRELKIEPDLGYS
FMGVRDCSPPCPNMYFRKDELIFARYFIGVISIVCLSATLFTFLTFLIDVGRFRYPERPI
IFYAVCYMMVSLVFFLGFLLEDRVSCNTASPGRFRASTITQGSHNKACTLLFMTLYFFTM
AGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHAVAWGVPGALTITLMAMNKIEGDSMS
GVCFVGLYDLMALRWFLLVPLVLDVIVGVVLLLAGIAALNRVRMEIPLEKENQDKLVKFM
IRIGVFSVLYLVPLLTVIGCYLYEQSHRSVWETTWVQERCREYHIPCPFKVEKTSRPDIA
LFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFSGHRRKDAVHESRQVLQEPDFTQLLLR
DPNTPVVRKSRGTSTQGTSTHASSTHLAMLDEPPSASTSRAGSTRSKSSSFHGSLHRSRD
GRYTASSFRGVEERVSHGSSLRLNEPLQHCAINRLDSQSRHGSLQRLESQSRHSSVRDLS
ITAQAIQSSPGNGIHRVMEEDATKA
>Takifugu rubripes_FZD6(ENSTRUP_17077)
MLMPGPLWTCLALMWLGSSSAHSLFTCEPIKVHRCLGMSYNMTFFPNMMDHFDQDIAATH
MKPFMPLVNLRCSPDVHRFLCQAFFPACIENTVYRPCREECNTVMSECKANIEVFGISWP
PELQCDNFFRLDPCFLIGHETSTETTPVTSSTKRDLGFWCPLQLKTKPGLGSSFLGTQDC
APPCSNMYFKPHDIEFAKSFIGVCSIICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCY
SFVSLMYFIGFLLGNNAACTKATHPASVDTVVLGSQSKGCTLLFMLLYFFSIAGLVWWVI
LTITWFLAAGPKWSCEAIEKKAVWFHSAAWGIPGSLTVMLLALNKVEGDNISGVCFVGLY
NLDALRYFVLAPLGVGVIVGLFLILAGIVSLNNVRQVIQHDERNQEKLKKFMIRIGVFSC
LYLVPLVTLLACYTYEQSHRSAWERTWIADRCQEYSIPCPFEAAESDRPDLSLFLVKYLM
TLVVGISAVFWVSSKKTCSEWAYFFNRTRKKDPISESRRVLQESCEFFLKHNSRVQHKKK
HYSPSSHKLKVISKSMGTSTGAMPSNASATPTLTNHGASTLSNRDAHPQCSLSEASVRSS
RRGVRDREREVGERQSKGGSSSKI
>Tetraodon nigroviridis_FZD6(ENSTNIP_11048)
MLMPGPLWTCLALMWLESSTAHSLFTCEPIKVHWCLGMPYNMTYFPNMMDHFDQDIAATN
MKPFMPLIKLRCSPGVHHFLCQAFFPACFENVGSRPCREECKTVLSDCKDNIQVFGISWP
PELQCDNRLDPCFLTRDDTTPETPPATSPTKRDLGFWCPLQLKTKPGLGSSFLGAQDCAP
PCSNMFFKPHDVEFAKSFIGVCSIVCLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSF
VSLMYFIGFLLGDSVACARASHPASVDTVVLGSQSKACTLLFMLLYFFSVAGLVWWVILT
ITWFLAAGPKWSCEAIEKKAVWFHSAAWGIPGLLTVMLLALNKVEGDNISGVCFVGLYDL
DALRYFVLAPLCVGVAVGLFLILAGIVSLNNVRQVIQHDERNQEKLKKFMIRIGAFSCLY
LVPLVTLLACYTYEQSHRSAWERTWIRDRCQEYSIPCPSEAAELERPDLFLFLVKYLMTL
VVGISAVFWVSSKKTCSEWAYFFNRTRKKDPISESRRVLQESCEFFLKHNNRVQHKKHHS
PSSHKLKVISKSMGTSTGAVPLNAPPASVLTNHGTSAVGNHD
>Gasterosteus aculeatus_FZD6(ENSGACP_6519)
MPGPLLACVCLVWVGSCRAHSLFTCEPIRVHRCLGLTYNMTYFPNMMEHYDQDIAEAAMT
PFMPLAGLPCSPDVHHFLCQAFVPACSEDNKVIRPCRERCESVVSDCEEDVRVFGITWPP
ELQCDRLEPCGSAGVPTLPATTAISSSSAKRDLGFWCPLQLKTKPGHGSSFLGAQGCAPP
CANMYFKPHDVEFAKNFIGVCSVICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFV
SLIYFVGFLLGNNAACAGGDLPAGVDTVVLGSQSKGCTLLFMLLYFFTIAGIVWWVILTI
TWFLAAGPKWSCEAIEKKAVWFHSVAWGIPGALTVMLLALNKVEGDNISGVCFVGLYDLD
ALRYFVLAPLCVGVVVGLFLILAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSCLYL
VPLVTLLACYTYEQSHRSSWENTWIHDRCQEYSIPCPYKVAETQEHERPDLSLFLVKYLM
TLVVGISASFWVSSKKTCSEWAYFFNRTRKRDPITESRRVLQESCEFFLKHNSRVQHKKQ
QYKPSSHKLKVVSKSMGTSTGAVPTNASSAGAAPGNHDPRGRGSPSEASAREHLDRGTSS
RSSKRGERSAAAPRACTESRTGG
>Oryzias latipes_FZD6(ENSORLP_2877)
PLWLGLALVWVGSCRAHSFFTCEPIKVHRCMGMPYNMTFFPNMMEHYDQEIAASKMEPFM
PLANLRCSPDVHHFLCQAFIPACTEDNRVIRPCREKCRAVLSDCRENIRIFDVTWPPELQ
CDKLDPCVVDGSVPPTTAQQTPSSPKRDLGFWCPLQLKTKAGQGSSFLGTQDCAPPCSNM
FFKPHDIEFAKSFIGVCSIICLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVSLIY
FIGFLLGDSAACAKASHHAAVDTVVLGSQSKGCTLLFMLLYFFTMAGMVWWVILTITWFL
AAGPKWSCEAIEKKAVWFHSAAWGIPGALTVMLLALNKVEGDSISGVCFVGLYDLDALRY
FVLAPLCVGVIVGLILILAGIVSLNHVRQVIQHDERNQEKLKKFMIRIGVFSCLYLLPLV
TLLACYTYEQSHRSSWENTWINDRCQEYSIPCSYKTATPDRPDLSLFLVKYLMTLVVGIS
AVFWVSSKKTCSEWAYFFNRTRKRDPISESRRVLQESCEFFLKHNTRVQHKKKHYKSSSH
KLKVISKSMGTSTGAAPTNAGTTSSSGNHETLLEGSLSDTLVREQMDRTTAARSSRRGER
EGGERRSKGGSSSRISSHSESVHRAADGRWDETSRSHSER
>Homo sapiens_FZD7(ENSP_286201)
MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI
AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC
RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYP
TAPYLPDLPFTALPPGASDGRGRPAFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRAN
GLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLT
WFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDA
LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTV
PATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIV
GITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
>Gorilla gorilla_FZD7(ENSGGOP_10544)
MRDPGAAAPLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDI
AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC
RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYP
TAPYLPDLPFTALPPGASDGRGRPGFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRAN
GLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVA
VAHVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLT
WFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDA
LRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTV
PATIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIV
GITTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
>Mus musculus_FZD7(ENSMUSP_109884)
MRGPGTAASHSPLGLCALVLALLGALPTDTRAQPYHGEKGISVPDHGFCQPISIPLCTDI
AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC
RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYP
TAPYLPDPPFTAMSPSDGRGRLSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGL
MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVA
HVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWF
LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALR
GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPA
TIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPDFTVFMIKYLMTMIVGI
TTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
>Rattus norvegicus_FZD7(ENSRNOP_21569)
MRGPGTEASHSPLGLCALVLALLGALPTDTGAQPYHGEKGISVPDHGFCQPISIPLCTDI
AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPC
RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGAGGSPTAYP
TAPYLPDPPFTAMSPSDGRGRWSFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGL
MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVA
HVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWF
LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALR
GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPA
TIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFSPMSPDFTVFMIKYLMTMIVGI
TTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV
>Gallus gallus_FZD7(ENSGALP_30969)
MRPAAGGAGAGLRWLGLAALLAALLGTPCAAAHQDDKAISVPDHGFCQPISIPLCTDIAY
NQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAPVCTVLEQAIPPCRS
LCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAPPGPGGAGGRGATA
QPTAGYLPDLLTPPQPAAGFSFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRPNGLMYFK
EAEVRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYAAG
FLLEERVVCLERFSEDGYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAG
MKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDVLSGVCYVGIYSVDSLRGFVL
APLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVL
ACYFYEQAFRSTWEKTWLLQTCKTYAVPCPSHFAPMSPDFTVFMIKYLMTMIVGITTGFW
IWSGKTLQSWRRFYHRLSTGSKGETAV
>Taeniopygia guttata_FZD7(ENSTGUP_10466)
GECGGAAAAGCPLLGLAALLAALLGTPAGATAQQYHGEKGISVPDHGFCQPISIPLCTDI
AYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELKFFLCSMYAPVCTVLEQAIPPC
RSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAPPGPGGAAGRGV
TAHPTAGYLPDFLTPPQPPSGFSFSCPRQLKVPSYLGYRFLGERDCGAPCEPARPNGLMY
FKEAEVRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYA
AGFLLEERVVCLERFSEDGYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLA
AGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDVLSGVCYVGIYSVDSLRGF
VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATI
VLACYFYEQAFRGTWEKTWLLQTCKTYAVPCPSHFAPMSPDFTVFMIKYLMTMIVGITTG
FWIWSGKTLQSWRRFYHRLSTGSKGETAV
>Anolis carolinensis_FZD7(ENSACAP_5043)
LLPPPLASSSSPMPRAPAMGLWGLLALSWMMPHASRGQPASSSSSQGEKGISVPDHGFCQ
PISIPLCTDIAYNQTILPNLLGHTSQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC
TVLEQAIPPCRSLCERARHGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDTSS
SSGGERRGAGVAPGSPATASYPTAHLPGPPAHPLPPTTGHAVFEFSCPRQLKVPPYLGYR
FLGERDCGAPCEPDLPNVGLMYFKQAEVRFARLLIGIWSVLCCASTLFTVLTYLVDMRRF
SYPERPIIFLSGCYFMVAVAYVAGFLLEDRVVCVERFSEDGFRTVVQGTKKEGCTILFMI
LYFFGMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQV
DGDVLSGVCYVGLYSVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTE
KLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFRDTWEKTWLLQNCKSYAITCPAANFAP
MSPDFTVFLIKYLMTMIVGITTGFWIWTGKTLQSWRRFYHRLSTGSKGETAV
\t
>Xenopus tropicalis_FZD7(ENSXETP_27115)
CRAPRIITCCRPGPGMFATVSLLFCLLLQPSPSAQQYHGEKGISVPDHGFCQPISIPLCT
DIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIP
PCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDNSPSGPTARPT
PYLPDSITFHPHPNRDFTCPRQLKVPPYLGYRFLGEKDCGAPCEPGKANGLMYFKEEEVR
FARLWVGIWAILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYTAGFLLEE
RGVCVERFSEDSYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKWGH
EAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFV
YLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVMYTVPATIVLACYFY
EQAFRDTWEKTWLVQTCKGFAVPCPNYNFAPMSPDFTVFMIKYLMTMIVGITSSFWIWSG
KTLQSWRRFYHRLSNGGKGETAV
>Danio rerio_FZD7a(ENSDARP_106912)\t
MAFLKMQHCCGITRYFLLLFTVALQTTSGQYHGEKGISIPEHGFCQPISIPLCTDIAYNQ
TIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSMDLKFFLCSMYAPVCTVLEQAIPPCRSLC
ERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDAGSPTSNPTPYVPELIT
LQPNLVVRPNQQFTCPLQLKVPTYLKYHFMGEKDCGAPCEPTRPNGLMYFREEEVKFGRL
WVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVC
IDKFSDDGYKTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLSAGMKWGHEAIE
ANSQYFHLAAWAVPAVKTITILAMGQVDGDMLTGVCYVGIYNVDSLRGFVLAPLFVYLFI
GTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAF
REQWEKTWHMQTCKRFAVPCPVNNFAPMSPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQ
SWRRFYKRLSNSNQGETTV
>Danio rerio_FZD7b(ENSDARP_38430)
MMAVREVGPCVYKTYCVFITTLLFGLSSAQYHGEKGISVPEHGFCQPISIPLCTDIQYNQ
TIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSQDLKFFLCSMYAPVCTVLEQAIPPCRTLC
ERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNKSDPDVPTTNPTPYIPEPFS
PRIHTPRQNQAFTCPLQLTVPSYLNYHFLGAKNCGAPCEHKQPYGLMYFKEEEVRFGRLW
VGIWSILCCVSTLFTVLTYLVDMRRFHYPERPIIFLSGCYFMVAVAYAAGFLLEDKVVCI
DKFRDDAFKTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWGHEAIEA
NSQYFHLAAWAVPAVKTITILALGQVDGDLLTGVCYVGIYNVDALRGFVLAPLFVYLFIG
TSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFR
EQWEKTWHMQTCKRFAVPCPNNNFAPMTPDFTVFMIKYLMTMIVGITSGFWIWSGKTLQS
WRRFYKRLGNNQGETTV
>Tetraodon nigroviridis_FZD7(ENSTNIP_6381)
MAAAGSTSGSVWLRIMWLLCGLFSEASAQHYNSESGISVPEHGFCQQISIPLCTDIAYNQ
TIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSADLKFFLCSMYAPVCTVLEQAIPPCRSLC
ERARQGCEALMNKFGFQWPERLRCEAFPVHGAGDICVGQNTSEPNGPSSSSSPYAPDPVT
LPPHLSRPDQGPPHHNQLHQFSCPLQLEVPSYMGYRFMGVKDCGAPCEPAKPTGIMYFRE
DEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGF
FLEDKVVCVDKFKEEGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLSAGM
KWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQVEGDVLTGVCFVGIFNVDSLRGFVLA
PLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIA
CYFYEQAFREHWERTWHMQICKRFAIPCPTHNFAPMTPDFTVFMIKYLMTMIVGITSGFW
VWSGKTLQSWRRFYKHLSYGNHGETTV
\t
>Oryzias latipes_FZD7(ENSORLP_19317)\t
IFARRYSPAFFATFFVFTPRLCMPAASAQHYSDSGISVPEHGFCQPISIPLCTDIAYNQT
IMPNLLGHTNQEDAGLEVHQFYPLVKVQCSTELKFFLCSMYAPVCTVLEQAIPPCRSLCE
RARQGCEALMNKFGFQWPERLHCEAFPVNGGSEICVGQNTSEPGSPSSSSPHVPELVTVP
PNRFPNPPQPPHNSYHQFSCPLQLEVPSYLGYRFMGVKDCGAPCEPTKPSGIMYFREDEV
KFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLE
DKVVCVDKFKGEGFRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLSAGMKWG
HEAIEANSQYFHLAAWAVPAIKTITILAMGQVDGDVLTGVCFVGIFNVDALRGFVLAPLF
VYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYF
YEQAFREHWERTWHMQTCKRFAVPCPVHNFAPMTPDFTVFMIKYLMTMIVGITSGFWVWS
GKTLQSWRRFYKRLGNGNHGETTV
>Homo sapiens_FZD8(ENSP_363826)
MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGS
GHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVS
VSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFL
IDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGA
GAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLT
WFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDN
LRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLY
TVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITS
GVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGG
GGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
>Mus musculus_FZD8(ENSMUSP_39660)
MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPPGEQPPSG
SGHSRPPGARPPHRGGSSRGSGDAAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSS
ERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDM
ERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAAGAGA
AGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWF
LAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLR
GFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTV
PAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGV
WVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGSGPGPGGGGGHGGGGGSLYSDV
STGLTWRSGTASSVSYPKQMPLSQV
>Rattus norvegicus_FZD8(ENSRNOP_55627)
MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGS
GHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSE
RHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDME
RFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAA
GAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFL
AAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRG
FVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVP
AAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVW
VWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGPGPGGGGGHGGGGGSLYSDVS
TGLTWRSGTASSVSYPKQMPLSQV
>Taeniopygia guttata_FZD8(ENSTGUP_931)
GPAKHQPEQQGKERVRYESTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGN
EAIAGYAQYFHLAAWLLPSVKSIAVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLLI
YLAIGSMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAASVVACL
FYEQHNRPRWEATHNCPCLRDQQPDQARRPDYAVFMLKYFM
>Anolis carolinensis_FZD8(ENSACAP_1050)
RARFPSPSMDRSLLLALLALLPASASASSSASLSCQEITVPLCKGIGYNYTSMPNQFNHD
TQDEAGLEVHQFWPLVEIQCSSDLRFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAP
LMRQYGFAWPDRMRCDRLPAQGDPDTLCMDYNRSEAATTPPPAPPPQAPPPPPPRAPPRK
PLPPLPPTPPGAPPLCKPDCGARGDARALLPCSRQGRIPNFPWPARILLHPNERAFTAFW
IGLWTIICFLSTFATVSTFLIDMERFKYPERPIVFLAACYLFVSLGYLVRLVAGHEKVAC
SAGAEHVRYESTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYAQ
YFHLAAWLLPSVKSIAVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLLIYLAIGSMF
LLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAASVVACLFYEQHNRP
RWEATHNCPCLRDQQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWKALCTR
CCWASKAAAVGGLGGGAGSMYSDISTGLTWRSGTASSVSYPKQMPLSQV
>Danio rerio_FZD8(ENSDARP_66834)
MECYLLGIYLFLALALLPRSSGTTAKEITCQEIAVPLCKGIGYNYTYMPNQFNHDTQDEA
GLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQY
GFPWPDRMRCDLLPVQGAPDTLCMDYNRTDSTTVSPVLSKPTNYPSKAINPHKKKSGRPG
VGPNKNKPCEPGCQCRAPMVPVNSDRHPLYNRVKTGQIPNCAMPCHNPYFTQDERTFTAF
WIGLWSVLCFISTFATVATFLIDMERFKYPERPIIFLSACYMFVSIGYIVRLIAGHEKVA
CNREYDVEHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAG
YSQYFHLAAWLIPSMKSIAVLALSSVDGDPVAGICYVGNQNLDNLRGFVLAPLVIYLFIG
TMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNR
QSWEITHNCSCLLEQEIKRPDYAVFMLKYFMCLLVGITSGVWTWSGKTLESWRSFCTRCC
WGSKGSGGSMYSDVSTGLTWRSGTASSVSCPKQMPLSQV
>Tetraodon nigroviridis_FZD8(ENSTNIP_10799)
MDRSIPGPCVLLLLVLSTAGCMAAKERQCQEITVPLCKGIGYNHTYMPNQFNHDTQDEAG
LEVHQFWPLVEIKCSPDLRFLLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYG
FPWPDRMRCELLPEQGNKDTLCMDYNRSQTTTAAPVVAKPTNRPLKPYNPRKKPGGGRVI
PGKHKPATPPCEPGCFCRGPMVPLSSDAQQLHSRVKTGQILNCAMPCHSPYFTPEERTFT
AFWIGLWSVLCFISTFATVATFLIDMDRFKYPERPIIFLSACYMFVSVGYIVRLIAGHEE
VACSRDAGAEHIHYDTTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAI
ASYAQYFHLAAWLIPSLKSIAVLALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLVIYLF
IGTMFLLAGFVSLFRIRSVIKQGGTKTDKLERLMIRIGVFTVLYTVPATVIVACYFYEQH
HRETWEIAHNCTCLTEPSRPRPDYAVFMLKYFMCLLVGITSGVWIWSGKTLDSWRTFCTR
CCWGSKASAGSMYSDVSTGLTWRSGTASSVSCPKQMPLSRV
>Gasterosteus aculeatus_FZD8(ENSGACP_2308)
EHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAAGMKWGNEAIASYSQYFHL
AAWLIPSMKSIAVLALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAG
FVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATIIVACYFYEQHNRQSWEITH
NCSNCLLERDRSSPDYAVFMLKYFMCLLVGITSGVWIWSGKTLDSWRTFCTRCCWGSKG
>Oryzias latipes_FZD8(ENSORLP_6033)
DTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERARAGCA
PLMRQYGFPWPDRMRCDLLPVQGNPDTLCMDYNRNDSTTASPVLSKPTNHPGRSPKSKPG
RAGAPGKYKPPAAPCEPGCRCLEPMVAVTTERHPLYNRVKTGQVTNCAMPCHNPYFTHDE
RAFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVSVGYIVRLIA
GHEKVACNRDFDVEHIHYETTGPALCTIVFLLIYFFGMASSIWWVILSLTWFLAAGMKWG
NEAIASYAQHFHLAAWLIPSMKSIAVLALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLV
IYLFIGTMFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTVLYTVPATVIVACYF
YEQHNRQDWEMTHNCSSCLMERERARSGPDYAVFMLKYFMCLLVGITSGVWIWSGKTLDS
WRTFCTRCCWGSKGTGGSMYSDASTGLTWRSGTASSVSCRKQMPLS
\t
>Homo sapiens_FZD9(ENSP_345785)
MAVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNL
LGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARL
RCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPA
RPPGDLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSA
LCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGA
LYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHM
AAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTG
FVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRA
TEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSL
CYRKIAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
>Mus musculus_FZD9(ENSMUSP_53551)
MAVPPLLRGALLLWQLLATGGAALEIGRFDPERGRGPAPCQAMEIPMCRGIGYNLTRMPN
LLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQAR
LRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPTEPHKGLGMLPVAPRP
ARPPGDSAPGPGSGGTCDNPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWS
ALCFFSTAFTVFTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAG
ALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFH
MAAWGLPALKTIVVLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLT
GFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLR
ATEQPCTAATVPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQS
LCYRKMAAGRARAKACRTPGGYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
>Rattus norvegicus_FZD9(ENSRNOP_1973)
MAVPPLLRGALLLWQLLATGGAALEIGRFDPERGRGPAPCQAMEIPMCRGIGYNLTRMPN
LLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQAR
LRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPTEPHKGLGMLPVAPRP
ARPPGDSAPGPGSGGTCDNPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWS
ALCFFSTAFTVFTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAG
ALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFH
MAAWGLPALKTIVVLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLT
GFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLR
ATEQPCTAAAVPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQS
LCYRKMAAGRARAKACRTPGGYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
>Taeniopygia guttata_FZD9(ENSTGUP_3193)
RCQPVDIPMCRGIGYNLIRMPNMLGHESQREAALKLHEFAPLVEYGCHVHLRFFLCSLYA
PMCTDQVSASIPACRPMCEQARHKCVPIMEQFNFGWPESLDCGRLPTKNDPNALCMEAPE
NASAAEPHKGQGMLPVAPRPWPPGTATEGRGPNGLGACSNPEKFQYVEKSLSCAPRCSPG
VDVYWSREDKDFAFIWMAVWSTLCFVSTAFTVLTFLLDPHRFQYPERPIIFLSMCYNVYS
VAFIIRSVAGAENIACDRENSELYIIQEGLESTGCTIVFLILYYFGMASSLWWVVLTLTW
FLAAGKKWGHEAIEAHSSYFHMAAWGIPAMKTIVILTMRKVAGDELTGLCYVGSMDISAL
TGFVLIPLSCYLVIGTSFILTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVP
ATCVIVCYFYERLNVDYWMLRALEHGCLRLPGRRAIDCSLETSVPTVAVFMLKIFMSLVV
GITSGVWVWSSKTLQTWQSLCNRRLGMRTRSKPCSGVSCGG
>Danio rerio_FZD9(ENSDARP_6458)
MGSSPLQIVISLWCHLVIAAYSLEIGSYDLERGRPAKCEPIVIPMCQGIGYNLTRMPNFM
DHDNQREAAIKLNEFAPLVEYGCDVHLRFFLCSLYAPMCTDQVSTSIPACRPMCEQARQK
CSPIMEKFNYAWPESLNCSKLPTRNDPNALCMEAPENDTKTETKKGEGMLPVPPRPRQPG
AGNARSGGTMGVCENPEKFQYVEKSETCAPRCSSAVDVFWSRQDKDFAFIWMAVWSTLCF
VSTAFTVLTFLLDPHRFQYPERPIIFLSMCYNVYSVAFIIRSVAGAENIACDRENGELYI
IQEGLESTGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIESHSSYFHMAAW
GIPALKTIVILTMRKVAGDELTGLCYVGSMDVGALTGFVLVPLSCYLVIGTSFILTGFVA
LFHIRKVMKTEGTNTEKLEKLMVKIGIYSILYTVPATCVIICYFYERLNMDYWKFRGLQS
KCTTFPGRRNEDCSLDSSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLCSRKL
TDRTCRKHCSTSHCHYKAPAVILHMSKTDPYSDCPTHV
>Gasterosteus aculeatus_FZD9(ENSGACP_10090)
PLTAVLLLWGLLVISGSGFEIGSYDLERGRPAKCEPIVIPMCEGIGYNLTRMPNFMDHDD
QKEAAIKLNEFAPLVAYGCDVHLRFFLCSLYAPMCTDKVSTSIPACRPMCEQARERCAPI
MKKFSYTWPDSLDCSKLPTRNDPNALCMEAPENETRTEGKKGEGMLPVPHRPRQPGGGRS
SGGAGSCENPDKFQFVEKSQSCAPRCSPAVDVFWSRQDKDFAFIWMTVWSILCFVSTAFT
VLTFLLEPHRFQYPERPIIFLSMCYNVYSVAFIIRSVAGAENIACDREHGELYIIQEGLE
STGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIEAHSNYFHMAAWGIPALK
TIIILTMRKVAGDELTGLCYVGSMDPGALTGFVLIPLSCYLIIGTSFILTGFVALFHIRK
VMKTEGTNTEKLEKLMVKIGIYSILYTVPATCVIVCYFYERLNMDYWKLRGLQMKCGSFG
GPSGDCSLRASVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLCSRKLADRTRSR
KPCGGVSCASTHCHYKSPAVVLHMAKTELHSDSPTHV
>Oryzias latipes_FZD9(ENSORLP_14516)\t
FLWALLPVSASSLEMSFYDLERDRPAKCEPIVIPMCVGIGYNLTRMPNFMDHDDQAEAAI
KLQEFAPLVDYGCDVHLRFFLCSLYAPMCTDKVSTSIPACRPMCEQARDKCAPIMKKFSY
TWPDSLDCSKLPTRNDPNALCMEAPENETRTEGKKDKKKGEGMLPVPPRPRQPDTPSSRL
PGSGNSCENPDKFQFVEKSQSCAPRCSPAVDVYWSRQDKDFAFIWMTVWSILCFVSTAFT
VLTFLLEPHRFQYPERPIIFLSMCYMVYSLAFIIRSVAGAENIACDREHGELYIIQEGLE
STGCTIVFLILYYFGMASSIWWVILTLTWFLAAGKKWGHEAIEAHSNYFHMAAWGIPALK
TIVILTMRKVAGDELTGLCYVGSMDSGALTGFVLIPLSCYLIIGTSFILTGFVALFHIRK
VMKTEGTNTEKLEKLMVKIGIYSILYTVPATCVIVCYFYERLNMDYWKLRGLQEECDSFS
SHNSKCSLETSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTLQTWQGLCSRKLSDRTSSR
KPCSGVSCSSTHCHYKSPTAVLHMAKTDLHSENPTHV
>Homo sapiens_FZD10(ENSP_229030)
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHEN
QREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPI
MEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEH
PLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFF
SSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVI
QEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWA
IPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVAL
FHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHK
CKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLK
KKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
>Mus musculus_FZD10(ENSMUSP_114114)
MQHPGPRLWLVLQVMIGSCTAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHE
NQREAAIQLHEFAPLVEYGCHSHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSP
IMEQFKFRWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQE
HPLKDGGPGRAGCDNPGKFHHVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCF
FSSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYV
IQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAW
AIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVA
LFHIRRVMKTGGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQH
KCKMNNQTKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGL
KRKSRRKPASVVTSAGIYKKAQHPQKPHLGKYELPAQPSACV
>Anolis carolinensis_FZD10(ENSACAP_14030)
ERPGESRCQPIAIPMCQDIGYNVTRMPNLMGHEDQREAAIQLHEFAPLVEYGCHGHLRFF
LCSLYAPMCTEQVSAPIPACRVMCEQARLKCSPVMEQFTFRWPDSLDCSRLPSKNDPNFL
CMEAPSNGSEEPPKPGPLPPLFRPHRPHEHEPPPPKGVPSCGNPGKFRRVEKSASCAPLC
SPGVDVYWSRQDKRFAAVWIGVWSVLCFFSSAFTVLTFLVDPQRFKYPERPIIFLSMCYC
VYSLGYLIRLFSGAESVACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVILT
LTWFLAAGKKWGHEAIEANSSYFHLAAWAVPAVKTIVILVMRRVAGDELTGVCYVGSMDV
DALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTAKLEKLMVRIGVFSVLY
TVPATCVIACYFYERLNMDYWKVLAMQQKCKVNGNQTKHLDCTMSKSIPAVEIFMAKVFM
LLVVGITSGMWIWTSKTLQSWQNVCSQRLKKRTRRKPASVIASSGLYQKTQHPPKGHHTK
YESALQPPTCV
>Danio rerio_FZD10(ENSDARP_89291)
MFAAGVGLSLGLLCFAGFCSAISSIDPDRPGEGRCQEIAIPLCKDIGYNLTVMPNLMGHE
DQNEAAIKLHEFAPLIEFGCHSHLKFFLCSLYAPMCTEQVSTPIPACRVMCEQARQKCSP
IMEQFNFHWPESLDCSRLPNKNDPNYLCMEAPNNGTDEPPKGSHTQSPDSRPPRPGNSQE
LPIKERVGKTTCSNPGKFHYVQKSESCAPKCYSNVDVYWSQGDKRFSMVWIAIWSILCFI
SSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYSVGFLVRLFVGVENVACDRDTGVQYII
QEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAAWA
IPAIKTIMILVMRKVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLIIGTSFLLSGFVAL
FHIRKVMKTEGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKILAGEQK
CADDGKSGEECVMKSSIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQNVFSRKLKK
KTRRKAACVFTGSGPYLKPHPALKGHKTKYEPAGPPATCV
>Tetraodon nigroviridis_FZD10(ENSTNIP_8515)
MPLIFQLRLICVLLVLYSTEGSAISSMDPEWSGERRCQQINIPLCKDIGYNMTRMPNLMG
HDDQKEAAIKLQEFATLIQFGCHSRLKFFLCSLYAPMCTEQVSNPIPACRVMCEQVKLKC
SPILEQFNFPWPESLDCSRLPTKNVPNNLCMEAPNNGSEEPPKVSQTQPPDFRPQQPLGG
QDLQLKDSGGKQKCPNPSKFHFVEKSESCAPKCYPSVDVYWSQGDKRFSLVWIAIWSILC
FVSSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYSVGYLIRLFVGAEGIACDRDNGVQY
IIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEANSSYFHLAA
WAIPAVKTIMILVMRKVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLVIGTSFLLSGFV
ALFHIRKIMKTEGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWRVRAEG
EKCMDGSRPESNECLLKSSIPAVEIFMVKVFMLLVVGITSGMWIWTSKTLQSWQNVFSRK
LKKRTRRKAASVFTSTRPYIKPPPSLKGHSTKYEPTRPPPTCV
>Oryzias latipes_FZD10(ENSORLP_17110)
RALSADPFPFRRGISLFLLKSFWFHFYLLFWISSSIDPDWSGEGRCQHITIPLCKDIGYN
MTRMPNLMGHDDQLEAAIKLQEFASLIQCGCHSHLKFFLCSLYAPMCTEQVSNPIPACRV
MCEQVKVKCSPILEKFQFPWPDSLDCSRLPTKNDPNNLCMEAPNNSSDEPPKVPHTQPPD
FRPQQPLSGQDLHPKDIGEKQTCSNPGKFHFVEKSESCAPKCYPKVDVFWSQGDKQFSLV
WMAIWSILCFVSSAFTVLTFLIDPQRFKYPERPIIFLSMSYCVYSVGYLIRLFVGADGIA
CDRDNGVQYIIQEGLESTGCTIVFLILYYFGMASSLWWVILTLTWFLAAGKKWGHEAIEA
NSSYFHLAAWAIPAVKTIMILVMRKVAGDELTGVCYVGSMDVKALTGFVLIPLSCYLIIG
TSFLLSGFVALFHIRKVMKTEGENTDKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNM
DYWRILAWKQKCVDGSRPESDECVMKASIPAIEIFMVKIFMLLVVGITSGMWIWTSKTLQ
SWQNVFSKKVKKRTRRKAAS
>Ciona intestinalis_(ENSCINP_26933)
MDIKLGIIILCCVISEVSTSNVHPQCRPVTLPMCLRNDNERNKGIKWIYNETTFPNFNND
ASESEVEISLSLLHPLLSTSCSRYLELFLCSVFSPACMGGGVVPPCRSLCEVVFDDCAEV
VEAFGIIWPQRLHCDNFPPQNGGKMVDTGSDTWGKMVVSRSSWLVWGEALLGDGEVCIPL
SGDDVITPALSQNNQEIDNVTKYPGEYGLRCPAQLTAPPNEPGYTFLGMQGCGAPCPNMY
MGDDELMLVRYIICVLASLCALVTSFVLFTFAIDTNRFRYPERPIVFYAAAYFVISVIFL
VGFALGSDVACKHEIMDENNIVIQGAVVVEGPRDRACTIVFMILYFFTVNGTIWWLILTV
TWLLAAGFKWGSEAIEKHHLYYHGLAWGIPAVQTMVVVTTGKIEGDNIAGVCFVGLYDSD
GLRFLLLLPMSFYLLVGMFVLLTGFICLNRVRKSLHDDETNKKKLAKFMLRIGVFSILYI
LPQLALIAIYAIEDSNRKSWESAWFVRNCGRYGVPCPNLPHPVAQLAQGNPLPGVFIFCM
KYIMTLIVALPPLFWVASKKTMASWKEAVTKQRCMDDGNPLSVTQTQLLNDSNNGPHARD
AVRKQQSKHSDVIFGGLGGFQGSSASIAAAEAMTSSRARARQELWEDMTSTDSTLSSRSE
STLAKVLEYESHKNKGRRVVGRRRHNQGHPLPLTHNPDEGENNREVDDVINKPVPIKMER
NNRIDDVISSQSRSLSDVTRPQSSVTSQPGRPDVVKKQLSISRSDATRSVPDIIKTTELS
PPLLRNKPEIPRKPKLSLAKPNTSGRVLEV
>Ciona savignyi_(ENSCSAVP_1900)
MKAFGRFKEYSTFAFMLLMLGESESQNVHNGKCELITLSICKGIRYNETIFPNVLGHQDQ
AEAGLQINQFYPLVKVGCSKTLQSFLCSVYTPMCSIYQQAFPPCRHMCEEARACEGIMKQ
FRFSWPRDLECSRFPIKTEDSLCFGTDISPSEEIPAFDTGRLCLSQAGFTCPAHMLVPST
NDLNYEFMDAEGCGVPCDAKKLMYWTESEKQFANLWIGCWSFICVISTLFTVLTYLIDMP
RFMYPERPIIFLSGCYLIVAIAYIAGFFLRDTVSCRQFHTSICPVDTPLSSCPKVVTQGA
REAGCTVLFMMVYFFSMASSIWWVVLTITWFLAAGLKWGNEAIEAKSPYFHGAAWSIPAI
QTIVVLISSKIEGDLLSGICFVGVHNSKHLLWFLLVPLSIYLFVGTCFLVAGFVAMFNIR
NVVKHSGGTGKVEKLERLMVRIGVFSVLYTVPATVMIACYFYEQMNRDSWQKGWFAQNCR
KMSVPCPCEYAKHKGNKPDFIVFIIKYFVMLIVGITSGFWIWSSKTVESWSNFKEQLCCF
RSSSQGGAKYQRGANNTVQQSGTLPLSGDVMRPLYPISKIDP
>Branchiostoma floridae_(XP_02605403)
MKMRVLVGFGWVGLLVLCCVLQGGTLVVRAQQFSSSSSLGHHGRCEAITIPLCTDIQYNETIMPNLLNHQ
KQEDAGLEVHQFFPLVKVQCSPDLKFFLCAMYAPVCTVLEEAIPPCRSLCNSARTGCEALMNKFGFQWPE
SLECSKFPVQGTPGKICVGENRTEQIPTAVPTANNGNSSAVTENPIRKDYGFYCPRELKVSPALGYSFLG
AKDCGAPCDSMYFRDDEVEFAQVWIGIWSVLCACSCLFTVLTYLIDPGRFRYPERPIIFLSACYLMVSVA
YIVGYALKEKVSCMEEHHRNFRRILHGTKKEGCTILFMMLYFFSMASSLWWVILTLTWFLAAGMKWGHEA
IEANSQYFHLAAWAVPAVKTIAILAMGKVDGDVLSGVCFVGISDIDALRGFVLAPLFLYLVIGTLFLLAG
FVSLFRIRTIIKQDGTKTDKLEKLMIRIGVFSVLYTVPATIVIACYFYEQAFRREWERSWEIDNCKDYFI
PCPPGPHARPSANPDFTVFMIKYLMALIVGITSGIWIWTGKTVQAWKRFYGQICFRKQDETVV
>Strongylocentrotus purpuratus_(XP_03724561)
MGWLVRENRHLAVGFLLTLMVVLFHFGAANAQFDYNEGITHGRCEAITIPLCEDMPYNMTIMPNLLNHQH
QEDAGLEVHQFYPLVKVQCSEDLKNFLCSMYAPVCTVLDSALPPCKSLCLSARNGCESLMNKFGFSWPAS
LSCDQFPEGGLCFDRNRTDERITIPSTKAPNITKQTEATVTKEVPFTCPLDLTVDHDWDYTFMRAQNCGA
PCNMYFHTPREQNFARYWVGCWAFVCAASSLFTVLTFLIDRSRFRYPERPIIFLSGCYFVISVVFIAGFF
LQDKVSCNRPYHPNAESTLVQGAKQQWCTILFMLLYFFQMASCLWWVLLSLTWFLAAGLKWGHEAIERNS
QYFHFAAWSIPAGKTIGVLATGQVDGDSLSGVCYTGIRDMNALRGFILAPLFVYLIIGCFFLCAGFIALF
RIRTFMKSDGNKTDKLEKLMIRIGIFSLLYTVPATIVIGCYIYEQANREIWEVAWLLGNCHHYSFGCPQA
QNLPEGITIDMLQAINLPGPDYLVFIVKYLMMLIVGITSSVWVWSPKTVRSWTQFYSKLCNFSSHPKGAP
ANV
>Apis mellifera_(XP_623523)
MIPRYAIYVFSVAVFSVNALHTKDPLAHHGRCEPITINLCMNIPYNETIMPNLMNHQKQEDAGQEVHQFA
PLVKMKCSPDLRFFLCTVYAPVCTIIDRAIPPCRSLCESARAGCERLMNSFGFAWPDNLDCSKLPENGGP
ELCVGHNETTPPEPSPPVYTPPRMPVAEFQPSWTGGPKTYGSGFMLGARDFGFVCPMQFKVPHELGYSLK
VGDKVELNCGAPCDGMFFTERERRFSRIWVGTWASVCAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYL
MVALAYVIGWAAGNSIACREPFPPPLDMRIQMASTITQGTKHELCTVLFMVLYFFGMASSIWWVILTLTW
FLAAGLKWGHEAIEANSQYFHLAAWAAPAIKTVTILAMGKVEGDILSGVCYVGLWNVEALRGFVLAPLCV
YLILGTAFLLAGFVSLFRIRTVMKHDGTKTDKLEKLMIRIGIFSVLYIVPALIVIACLFYEQAYFDQWML
TWNMEMCSRPGPQSLYSMPCPVGERTRDVGRRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQFFN
HIQGRRAEAYV
>Caenorhabditis elegans_(T23D8.1)
MHRHILILFLFGCLSADQRLSSTSISSMNGFSTTRKCEHITIPMCKNLDYNQTVFPNLLG
HTTQSEAGPAIAQFNPLIKVKCSEDIRLFLCTVYAPVCTVLEKPIQPCRELCLSAKNGCE
SLMKKFGFQWPDQLDCNKFPVTDLCVGKNSSESSNSKKSSNDVTFGVSTIANEVVLSPKK
CPHHMHTTSGSHFSLPLLSGRLPECSLTCEADNQVPMMFDGRVRRILRIWTAAWSVACFV
CSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAISTVYMIGVVGEDGFACGTYGSTPTTLV
TQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWFLAANLKWGAESIAALSPYFHAMCWG
VPAVLSVTVLVTNSVDGDVFTGICSVGNLNPSALVYFFFTPIVVSLALGAVLLVCGIWSM
IRIRSYIKLQHADVERNISKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNMPAWLEGW
LHHRCVRLQDRELFGFTYPVDDCPMDPKVAAPEIIVFLLKYVSQLVVGITCAIWVVSSKT
LSSYHKAYLALSSRSPTVPAHVDQVNMRD
>Nematostella vectensis_(XP_01647540)
MHFKVKSNVWFVIATILLYLRPCLPLKRCEPVTIPLCTGLQYNMTIFPNTLKHRTQEEAALEVHQFFPLV
KVDCSKDLAFFLCSVYAPVCTVLETPLPPCRSLCLTVRSGCEGLMKRFGFTWPDSLSCERFPKLGDEICV
GENTTTPTSDQDGGINNNTYPDVDMSTMRYRCPESQKIPNDQYTFHGEKRCAATCRNVFFTKREREIARM
WTGIWAILCAVSTLFTILTFLIDMRRFRYPERPIIFLSGCYFMVSIAFITGYVAGDKIACNEPIKKGFPK
TLVQGTKHEGCTVIFMMLYFFSMASSIWWVILTVTWFLAAGLKWGQEAIEANSQFFHLAAWAIPAVKTIA
ILLMTKVDGDELSGVCYVGLSDVSALRGYVLAPLFVYFIIGATFLLAGFISLFRVRSVLKDDYSKREKIE
KLMIRIGVFSILYTVPALVVIGCLYYEQSNRELWDNSWIEGWKRQKKCTEVETKLKGEVSCPPYPVPLQK
PDFMVFMVKYLMFLIVGITSGFWIWSSKTLNSWRRFYRRFILREKGRPNTSV
>Hydra magnipapillata_(ACC54556)
MRRNLYLHILKSVIIHLLCLNLIFCEPRGIRERYETRKCEKLSITMCEKVGYNLTFMPNKHGHVNQIDAG
QLIRQFAPLVAINCSPLLAHFVCSLYAPMCDPVYNKDIVPCQSLCENIRNSCEKFMKQNGYTWPDNLQCS
QFPTREKDPICMKPDFDFPEPSIPTHLNLPDENKKTSLIQTKDVFKIRDFSGCGCLCKYPFVSVNSSSNT
DLFPPCVLPCGQYFFSNTQNIFMKFWLSLWSILSLITTAVTLLTFLIDRTKFKFVEQPIILISFCYFIVS
FGYIIRLIYGFKAIACNDHTGFLHYASTGPASCTAVFILTYFFTNVSWIWWVVLSINWFLSSGLKWTNGT
ISSYSQYFHFVAWLIPTIQTMAILAMSAIDGDPVSGLCTVGNHDSNTLTIFVIGPLLIYTMLSLSFFIAG
VVAKLRIEQTIRNEAKNNLKSGRFLSRVGMFTLILFVPAVSLLGCYFYEHSYKEIWEKSTNCDCMPIKKQ
PIFYIFLFKYLMSLVIGIAIGLGTLNSDALGAWRRFFKRHCKITKSLAQEKNGQLIPNNSKKGVAI