>Homo sapiens_RSPO1(ENSP_383846)
MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL
HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL
HAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR
RRKGQQQQQQQGTVGPLTSAGPA
>Gorilla gorilla_RSPO1(ENSGGOP_7543)
MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL
HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKKKLCGFRRGSEERTRRVL
HAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR
RRKGQQQQQQQGTVGPLTSAGPA
>Macaca mulatta_RSPO1(ENSMMUP_11037)
MRLGLCVVALVLSWTHLTIGSRGIKGKRQRRISVEGSQACAKGCELCSEVNGCLKCSPKL
FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL
HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKKKLCGFRRGSEERTRRVL
NAPGGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGTGSR
RRKGQQQQQQGTVGPLTSAGPA
>Mus musculus_RSPO1(ENSMUSP_30687)
MRLGLCVVALVLSWTHIAVGSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQEGLYL
HKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCSKKRKLCGFRKGSEERTRRVL
HAPGGDHTTCSDTKETRKCTVRRTPCPEGQKRRKGGQGRRENANRHPARKNSKEPGSNSR
RHKGQQQPQPGTTGPLTSVGPTWAQ
>Oryctolagus cuniculus_RSPO1(ENSOCUP_9364)
MRLGLCVVALTLSWVHLAAGSRGIRGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
FILLERSDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCREGLYL
HKGRCYPACPEGSTASNGTLECGSPAQCEMSEWSPWGPCSKKKKLCGFRRGSEERTRRVL
HAPAGDHTACSDTKEARRCTVRRTPCPEGQKRRKGGQGRRENTHRNLARKDSKETGAGSR
RRKGQQQQPGTARPFTTAGPT
>Bos taurus_RSPO1(ENSBTAP_5002)
MRLGLCVVALVLSWMHLAAGSRGIKGKRQRRISADGGQACAKGCELCSEVNGCLKCSPKL
FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCQESLYL
HKGRCYPACPEGSAPADGTMECSSPAQCEMSEWSLWGPCSKKKKLCGFRRGLEERTRRVL
HAPGGDHAVCSDTKETRKCTVRRTPCPEGQKRRKGSQGRRENANRNPGRKESKEAGTGAR
RRKGQQQQQQGTEGPVTSLGPT
>Dasypus novemcinctus_RSPO1(ENSDNOP_20525)
MRLGLCVVVLVLSWMHLAAGSRGTKGKRQRRISVEGSQACAKGCELCSEVNGCLKCSPKL
FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKESLYL
HKGRCYPACPEGSAAANGTMECSSPAQCEMSEWSPWGPCSKKKKLCGFRRGSEERTRRVL
HVPAGDHAICSDTRETRRCTVQRTPCPEGQKRRKGGQGRREKVNRNPDRKESKEAGTGSR
RRQGLQQPQQQGTAGPVTSAGPT
>Myotis lucifugus_RSPO1((ENSMLUP_11140)
MRLGLCVVALVLSWMHLTAGSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKESLYL
HKGRCYPACPEGSAAANGTMECSSPAQCEMSEWSLWGPCTKRKKLCGFRRGSEERTRRVL
HAPGGDHAICSDTKEIRRCTVRRTPCPEGQKRRKGGQGRREKANRNPSRKESKEAGTGSR
RRKGQQQPQQQQQGTVGPLTSAGPT
>Ornithorhynchus anatinus_RSPO1(ENSOANP_3258)
MQLGLFAVLVILSWTDLAGGSKVAKGKRQRRISTEVSQGCAKGCELCSEFNGCLKCSPKL
FILLERNDIRQIGICLPSCPPGYYDARNPDMNKCIKCKIENCDACFSQNFCTKCKEGLYL
HKGRCYPDCPSGYSAANGTMECSSPAHCEMSEWSSWGPCSKKKKLCGFRKGTEERARRVL
NAPTGDRSGCPPAREVRRCTVQKSLCPEGPKRRKDEQGKRENGNGNHNRKEAKEARSGSR
RRKGQQQQQQQQRGTVLPLTLAGPD
>Gallus gallus_RSPO1(ENSGALP_3008)
MQLGLFVVVVFLSSMDLTGGSKVVKGKRQRRISTELSQGCARGCDLCSEFNGCLRCSPKL
FILLERNDIRQIGICLPSCPLGYFGLRNTDMNKCIKCKIENCESCFSRNFCTKCKEGLYL
HKGRCYVTCPEGYSAANGTMECSSPAQCEMSEWGPWGPCSKKRKLCGFKKGNEDRTRRIL
QAPSGDVSLCPATTEVRRCTVQKSQCPEGKRKKKDEQGKQDNTNGNRNRKDTKDAKSGTK
KRKSKQRGAVAPTTSASPAQ
>Pelodiscus sinensis_RSPO1(ENSPSIP_8505)
MQLGLFLVVVFLSLMDLAGSSKVVKGKRQRRISSEVSQGCAKGCDLCSEFNGCLKCSPKL
FILLERNDIRQIGICLPSCPLGYFGVRNPDMNKCIKCKIENCEACFSRNFCTKCKEGLYL
HKGRCYSTCPEGYSAANGTMECSNPAQCEMSEWGPWGPCSKKRKLCGFKKGNEERSRKVL
LAPSGDVSVCPATTEVRKCTVQKNQCPEGKRKRKEEQEKRDNMNGNRNQKDTKEAKSGTK
KRKSQQRGTVVPMTLASPAQ
>Xenopus tropicalis_RSPO1(ENSXETP_63528)
MQFGLFAVLVLILMDIADSNKFVKGRRHRRRSTEVSMVCAKGCDLCSEFNGCMKCLPKLF
ILLERNDIRQTGICLQSCPQGYFDDRNRENNRCLKCKINNCETCFSKNFCTKCKEGFYSH
KGSCYSSCPEGFSAVNGTAECSSVQCEMSEWGAWSPCSRTGQCGRKKGTEERSRIVVKAP
LGDLALCPPTTERRKCTMPKIPCTNRSLGMLKNQNKQELSKRKKEKNSKTQIEQDGSLKR
NKSQQKVTSIPSTPSLPVQ
>Danio rerio_RSPO1(ENSDARP_135809)
MHLGLLALALVFFSSMGHADNLKASKARRQRRISTEVPPSCSNGCEHCSEYNGCLKCRPR
LFILLERNDIRQIGICLAACPVGYYGIRNRDMNKCTQCKIENCEACFSRNFCTKCKEGLY
SHRGRCFSSCPEGFTVNGTMECVVQCDLSEWSPWGPCMKKNKTCGFKKGNQTRTREPLQV
PSPATSTGAAPASGCVPEIQTQRCTVQKKIPCKGENKKNQQNRGENSKNRGRDSKERGGN
KKRKNTNRSTTVPTITTSMVT
>Takifugu rubripes_RSPO1(ENSTRUP_24334)
MQLGLVVLAMIFLSSMGHSDALKLSKARRQRRVSPEMPLSCPKGCDRCSEYNGCIKCKPK
LFIFLERNDIRQIGVCLASCPIGYFGMRNPEGNNRCTQCKIENCEACFNRNFCTKCKEGL
YSHSGRCYVSCPQDQSAVNETMECVDCELGEWSQWSSCMKKNKTCGFRKGSQSRSRVPLP
QVHSPDTSLALVPSQTCAPETERKKCTLSKKAPCGRERNGKGDQQGDTNRRERENGRGHG
RNKGGGSRRKKGQSRTTSAPSITTSSVS
>Gasterosteus aculeatus_RSPO1(ENSGACP_18089)
MQLGLVALAMVFVSSVGHGDALRPSRGRRQRRVSTEGPPSCPKGCDRCSEYNGCIKCRPK
LFIFLERNDIRQIGVCLASCPVGYFGMRNPEGNNRCTQCKIDNCEACFNRNFCTKCKEGL
YSHSGRCYVSCPPGQRTANESMECVGQRADECILGEWSQWGSCMKKNKTCGFKKGSQSRE
RVPSQVHSPDASPAPEPSQTCAPQVERRKCSVTKTPCARGKRKIH
>Oryzias latipes_RSPO1(ENSORLP_18367)
MQLGLVALAMIILSSMGHSDVVKLSKARRQKRVSTEGPPSCPKGCDRCSEYNGCVKCKPK
LFIFLERNDIRQVGVCLASCPVGYFGMRNPEGNNRCTQCKIDNCEACFNRNFCTKCKEGL
YSHSGRCYVSCPPGQRTANETMECVGQHALKCELGKWSQWSSCMKKNKTCGFKKGSQFRV
RVPLQQTYAADSSSTLEETCTSQSERRKCVVPKTPCVKDRKNKGDNTNRRENRRGLGREG
KDGSRGGGGKRRRGPSRTTTVPSITTSSVT
>Homo sapiens_RSPO2(ENSP_276659)
MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH
RGRCFDECPDGFAPLEETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
VKDTILCPTIAESRRCKMTMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQHSVFLATDR
ANQ
>Pongo abelii_RSPO2(ENSPPYP_21114)
MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCAKGCEVGHWSEWGTCSRNNRTCGFKWG
LETRTRQIVKKPAKDTIPCPTIAESRRCKMTVRHCPGGKRTPKAKEKRNKKKKRKLTERA
QEQHSVFLATDRANQ
>Mus musculus_RSPO2(ENSMUSP_67325)
MRFCLFSFALIILNCMDYSQCQGNRWRRNKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH
RGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
AKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKRNKKKRRKLIERAQEQHSVFLATDR
VNQ
>Rattus norvegicus_RSPO2(ENSRNOP_71706)
MRFCLFSFALIILNCMDYSQCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKAGFYLH
RGRCFDECPEGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
AKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKRNKKKRRKLIERAQEQHSVFLATDR
VNQ
>Canis familiaris_RSPO2(ENSCAFP_995)
MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
FFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH
RGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
AKDTIPCPTIAESRRCKMAMRHCPGGKRAPKAKEKKNKKKKRKLIERAQEQHSVFLATDR
ANQ
>Bos taurus_RSPO2(ENSBTAP_18083)
MDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECL
HSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFEECPDGFAAL
DETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRR
CKMAMRHCPGGRKPDNNIGKK
>Pteropus vampyrus_RSPO2(ENSPVAP_402)
MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLF
FFLRREGMRQYGECLHSCPSGFYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLH
RGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
AKDTIPCPTIAESRRCKMAMRHCPGGRRAPKAKEKKNKKKRRKLTERAQEQHSVFLATDR
ADQ
>Ornithorhynchus anatinus_RSPO2(ENSOANP_23721)
ASYGANPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPLGYYGLRSPDMN
RCARCRIENCDSCFSRDFCTKCKAGSFLHRGRCFDECPDGFAPLEETMECVEGCEVGPWS
EWGVCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMALRHCPGGK
>Anolis carolinensis_RSPO2(ENSACAP_9991)
MQFRLFSFALIVLNCMDYSHCQGARWRRSKRANYGPNPICKGCLSCSKDNGCIRCQHKLF
FFLRREGMRQYGECLNSCPSGYYGLRAPDMNRCSRCRIENCDSCFSRDFCTKCKPGFYLY
RGRCFGECPDGFMPLEETMECVEGCEVGPWSEWGICSRNNKTCGFKWGLETRTRQIVKKP
AKDTLPCPTIAESRRCKMALRHCPGGKRTPKTKDKKKKKKNLMERAQKQHSLFLSTDRAG
Q
>Xenopus tropicalis_RSPO2(ENSXETP_63896)
MQFQLFSFVLIILNCVDYSHCQANRWRRSKRASYGTNPICKGCLSCSKDNGCLRCQPKLF
FYLRREGMRQYGECLQSCPPGYYGVRGPDMNRCSRCRIENCDSCFSRDFCIKCKSGFYSH
KGQCFEECPEGFAPLDDTMVCVDGCEVGPWSEWGTCSRNNRTCGFKWGLETRTRQIVKKP
AKDTIPCPTIAESRRCKMAMRHCPGGTRTTKKKDKKNKKKKKKLLERAQEQHSVVLATDR
SSQ
>Danio rerio_RSPO2(ENSDARP_100941)
MQFRLFSFALIVLNCVDYSHCQTQQSHRWRRNKRASYGAYPICKGCSVCSKDNGCMNCQP
KLFLFLRRERMRQYGECLHACPSGYYGMRGTEINMCSRCRIDDCEACFSKDFCTKCKLGF
YLHKGRCFEKCPEGFAPLEDTMECGEGCEVGQWSEWGTCARRNKTCGFKWGLETRTRHIV
KKPPKDTIPCPTIAESRRCKMAMRHCRKGGSGKGHRTKDQKKKSNKQRLRLRAQNQHSDH
LASIRAGQ
>Takifugu rubripes_RSPO2(ENSTRUP_13116)
MQFRLFSFALIVLNCMEYSNCQAPSHRWRRNKRASYGAYPICKGCSMCSRDNGCVNCQPK
LFLFLRRERMRQYGECLHDCPAGYYGMRSPELNMCSRCRIENCESCFSKDFCTKCKSGFY
LHKGRCFDRCPEGFAPLDETMECGEGCEVGQWSEWGACTKRNKTCGYKWGLETRTRHIVK
KPPKDTIPCPTIAESRRCKMPTRHCSRGKLLEKTKNKHLLKQRRKYI
>Gasterosteus aculeatus_RSPO2(ENSGACP_7152)
GCSVCSRDNGCVNCQPKLFLFLRRERMRQYGECLLDCPAGYYGMRTLEINMCSRCRIENC
ESCFSKDFCTKCKSGFYLHKGRCFDKCPEGFAPLEDTMECGEGCEVGQWSEWGACNRRNK
TCGYKWGLETRTRHIVKKPPKDTIPCPTIAESRMCKMAIRHCRRGKDV
>Homo sapiens_RSPO4(ENSP_217260)
MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRR
EGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLP
TCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAAT
CQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
>Pan troglodytes_RSPO4(ENSPTRP_22516)
MRAPLYLLLLVAHADMLALARWGEQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIHRE
GIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPT
CPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLETRVREAGWAGHEETATC
QVLSESRKCPIQRPCPG
>Mus musculus_RSPO4(ENSMUSP_41578)
MRAPLCLLLLLAHAVDMLALYRRKKQAGTGLGGNCTGCVICSEENGCSTCQQRLFLFIRR
EGIRQYGKCVHDCPLGFFGIRGQEANRCKKCGATCESCFSQDFCIRCKRRFHLYKGKCLP
SCPPGTLTHQSTRECQEECEPSPWGSWSPCIHNGKTCGSGWGLETRVREAGPAKQEETAS
CRVLSESRKCPIKRLCPGERNPRQKNRKDRRQRKDRKLERRPHQRGSQ
>Rattus norvegicus_RSPO4(ENSRNOP_12951)
MRAPLCLLLLLAHAVDMLALYRRKKQAGTGLGGNCTGCVICSEENGCSTCQQRLFLFIRR
EGIRQYGKCVHDCPLGFFGIRGQEANRCKKCGATCESCFSQDFCIRCKRRFHLYKGKCLP
TCPPGTLTHQSTRECQEECEPSPWGSWSPCIHNGKTCGSGWGLETRVREAGPAKQEEMAS
CRVISESRKCPIKRPCPGERNPRQKNRKDRRQRKDRKLERRLHQHGSQ
>Canis familiaris_RSPO4(ENSCAFP_10193)
VGTGLGGNCTGCVICSEENGCSTCQQRLFLFIRREGIRQYGKCVHDCPPGYFGVRGQEVN
RCKKCGATCESCFSQDFCIQCKRRFYLYKGKCLPTCPLGTAAQPSTRECQEECELGPWGS
WSPCMHNGKTCGSAWGLETRVREAGRAGREEAPTCQVLSESRKCPIQRPCPAGAEKNPSQ
KKGRRDRRPRKDRKLDRTLDVRPRPPAA
>Bos taurus_RSPO4(ENSBTAP_29170)
VGTGPGGNCTGCVICSEENGCSTCQQRLFLFISREGIRQYGKCVHDCPPGYFGVRGQEVN
RCKKCGATCESCFSQDFCIQCKRRFYLYKGKCLPTCPPGTAAQQSTRECQEECELNPWGS
WSPCTHNGKTCGSAWGLETRVREAGRAGREEAATCQVLSESRKCPIRRPCPGERNPNRKK
GQRERRPRKDRKLDGRGDGRPRPAP
>Pteropus vampyrus_RSPO4(ENSPVAP_2129)
MRVPLCLLLLVAHAADMLPLNRRKKQVGIGLGGNCTGCVICSEENGCSTCQQRLFLFIRR
EGIRQYGKCVHDCPSGYFGVRGQEINRCKKCGATCQSCFSQDFCIQCKRRFYLYKGKCLP
TCPPGTTAQQSTQECQEECELGPWGSWSPCTHNGKTCGSAWGLETRVREAGRAGQEEGAT
CQVLSESRKCPIQRPCPGERNPSQKKGRRDRRPRKDRKLDRKLDVRPPRPGRQW
>Monodelphis domestica_RSPO4(ENSMODP_24370)
MPWILLILLLFGNAVEMFALNHSKKQVGVGLKDNCTGCLICSEENGCSTCQPRLFLHIRR
DGIRQYGKCVHDCPHGYFGVRGHEVNRCKKCGSTCESCFSQDFCIRCKKRFFLHKGKCAP
TCPPGTIAQQSTWECQEECEFGPWSLWSPCLQDGKTCGSAWGLETRVREVSRGSREEGTA
ACQALSESRNCAIRRHCPGEKNLTRRRGRKERRHRKERKMEHS
>Taeniopygia guttata_RSPO4(ENSTGUP_7065)
GCVLCSEDNGCITCHHRLFLLIWRDGIRQYGMCVHTCPPGYFGVRGLEVNRCTKCRSPSC
ESCFNRDFCMMCKDNFTCTMASAFGCCPAGTAAQTGTRECQETCEPGPWSEWSACTHESR
TCGCRWGVETRVREVPEAAREEGTACPALLETRRCRMKKHCPGGEHRGQG
>Anolis carolinensis_RSPO4(ENSACAP_10663)
NCTGCIMCSEDNGCISCQQKLFLIIWRDGMRQYGACVHACPPGYFGVRGQEVNRCIKCRS
PNCESCFSKDFCIKCKQQFYLHKGKCLSTCPLDTIAQPSTQECLSKPEKCEMGPWGNWSP
CTNQGRTCGWRWGSAARSREAIKSSKEEAEACPVLTESRKCRMKKRCPGAKSPNKQNIST
RYYRKSSLAQESRLASRSSD
>Danio rerio_RSPO4(ENSDARP_123862)
XLLVQMHWQLLALLSLFCQMLLLTLAVRKRRESWRQDCRSCVLCSRENGCLRCSERLFLF
LRRDGILHHGSCLHSCPAGHFGLRGKELNRCMKCKAPECERCFNKDFCTKCKIGFLLFKG
KCFKSCPEGTFAQSTDCVEGCVFSVFGFWSEWSSCQHNGLSCGVTWGLQSRTRELSRNTP
EEKETLCPPQTESRKCQMKRRCRKDKRKNEKRQERRNAQKKLKLYGNRTITNPPQGNLNF
RSFVPQ
>Homo sapiens_RSPO3(ENSP_349131)
MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII
QHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES
SKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH
>Pan troglodytes_RSPO3(ENSPTRP_31716)
MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREII
QHPSVKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLES
SKEIPEQRENKQQQKKRKVQDKQKSGIEVTLAEGLTSVSQRTQPTPCRRRYL
>Callithrix jacchus_RSPO3(ENSCJAP_6657)
MHLRLISWFFIILNFMEYIGSQNASRGRRQRRTHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEAKNHTMECVNIVHCEVSEWNPWSPCTKKGKTCGFKRGTEIRVREII
QHPSAKGNLCPPPNETRKCTVQRKKCQKGERGKKGRERKRKKVNKGESKEAIPDSKDLES
SKETPEQRENKQQQKKRKVQDKQQKSVSVSTVH
>Mus musculus_RSPO3(ENSMUSP_90287)
MHLRLISCFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKVDCDTCFNKNFCTKCKSGFYL
HLGKCLDSCPEGLEANNHTMECVSIVHCEASEWSPWSPCMKKGKTCGFKRGTETRVRDIL
QHPSAKGNLCPPTSETRTCIVQRKKCSKGERGKKGRERKRKKLNKEERKETSSSSDSKGL
ESSIETPDQQENKERQQQQKRRARDKQQKSVSVSTVH
>Rattus norvegicus_RSPO3(ENSRNOP_15395)
MHLRLISWFFIILNFMEYIGSQNATRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDSCPEGLEASNHTMECVSIVHCEASDWSSWSPCMKKGKTCGFKRGTETRVRDIL
QHPSAKGNLCPPTSETRTCIVQRKKCSKGERGKKGRERKRKKLNKEDKKETSSSDSKGLE
SSRETSEQHESKERQQQQKRRAREKQQKSVSVSTVH
>Canis familiaris_RSPO3(ENSCAFP_1500)
MLKNSPPVTSCQEWPVLESRQQLPWPTLHPNVSQGCQGGCATCSDYNGCLSCKPRLFFVL
ERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKC
LDNCPEGLEANNHTMECVSIVHCEASEWSPWSPCMKKGKTCGFKRGTETRVREITQHPSA
KGNLCPPTSETRKCTVQRKKCQKGERGKKGRERKRKKPNKEESKDAVPDNKGLEPSRETP
EPRENKDKQQQKKRKVQDKQQKSSVDLFWGLKSS
>Loxodonta africana_RSPO3(ENSLAFP_2613)
MHLRLVPWFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLDNCPEGLEANNHTMECVSIVHCEASEWSPWSPCMKKGKTCGFKRGTETRAREIV
QHPSAKGNLCPPTSETRKCTVQRKKCQKGERG
>Myotis lucifugus_RSPO3(ENSMLUP_3791)
MHLRLISWFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYL
HLGKCLGNCPEGLEANNHTMECVSIVHCEASEWSAWSPCTKKGKTCGFKRGTETRVREIT
QHPSAKGNLCPPTSETRKCTVQRKKCQKGERGTK
>Monodelphis domestica_RSPO3(ENSMODP_22041)
MHLRLISWFFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFVLERNGMKQIGVCLSSCPSGYYGTRSPDINKCTKCKADCDTCFNKNFCTKCKNGFYL
HLGKCLDTCPEGLEANNHTMECASIVHCEASEWSPWSPCTKKGKTCGFKRGTETRFREII
QLPSAKGNLCPPTSETRKCMVQRKKCPKGERGKKGRERKRKKLNKEENKETRPENKGQDP
SSESRDQRENKDKQQQKKRKVQDKQQKSSMDLFGGLTSP
>Gallus gallus_RSPO3(ENSGALP_48902)
MQLRLISWFFIALNFMEYIGSQHASRVRRQGRMHPNVSQGCQGGCATCSDYNGCLSCKPR
LFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCAKCKADCDTCFTRNFCTKCKSGFYL
YSGKCLEKCPDGLEANNHTMECTSIVHCEASEWSPWSPCTKKGKTCGFKRGNEVRVREIV
QHPSARGNPCPATSESRKCMVQRKRCQKEGKGKKNREEKRKKSNKDESKESRQESKGRAA
RRQNREQRENNNKTQPKKRKAPSKEQDLAPVDTAH
>Xenopus tropicalis_RSPO3(ENSXETP_61149)
MQLRLLSLCFIILNFLEYIDSQQIPRGRRHRRMHPNVSQGCQGGCATCSDYNGCLTCKPQ
LFFALVRNGMKQIGVCRPSCPNGYFGTRSPEINKCTKCKADCETCFNKNFCTKCKSGFYK
HNGKCLDTCPEGFENNHNMECTSVVHCVVGEWSAWGPCTKRGKTCDIKRGNETRVREILQ
YPSPRGTPCPPTSETKKCVVKRKKCQDSQDRQRPRGNRDEIKKNKQRRKNGDAPRKQRQR
KQERNQREGKRGEGKV
>Danio rerio_RSPO3(ENSDARP_58577)
MQLQLISIVLILHFMEYTNCQHHGSRHRGNKQVSGVSSQGCQGGCQTCSVYNGCLTCKPK
LFIHLERDGMRQIGVCLASCPNGFYGTRSPDRNDCIKCGSECDSCFNRNFCLRCRAGSYL
HKGKCMESCPDGLVPSDTKKECVAACPALCDLCQNSDTCTRCVSGHFLHAGQCHHVCPDE
FEPNDSMECIPTVHCEVSEWSEWGTCSRSGKTCGFKWGEETRTRKVLQNPSPMGSPCPPT
SEKRECFVKKKRCKPPKGQRRGEKKKRFNLQEKVTAEARRERKREREKETIDREESESRN
KTEQRRRRDQSRDAGTV
>Takifugu rubripes_RSPO3(ENSTRUP_9205)
MQLHLISFVLIILHCMDYTGCQQHSSSRHWQHKQISGVSSGCQQGGCLTCSDYNGCLSCK
PRFFMHLERIGMKQIGVCVTSCPPGFYGTRFPERSPCTKCRSECDSCFAKNFCTRCRAGF
YLHLGKCQETCPEGLVRNEAQRECAPISLNLVHCEVGEWSEWSPCSRSGRTCRFKRGQET
RTRQVLRYPSPFGNPCPEISEIKECLVKRRKCPDPGGSERGRGRERERERERERERERER
KKERKKERKKERKKERKKERKKERISVVLVI
>Tetraodon nigroviridis_RSPO3(ENSTNIP_22293)
MQLQLISFALIILHCMDYTGCQPHSSSRHWQHKQISGVSSGCQQGGCLTCSDYNGCLSCK
PRFFMHLERIGMKQIGVCMTSCPPGFYGTRFPERSPCTKCRSECDSCFARNFCTRCRAGF
FLHLGKCQETCPEGLVRNEAQRECAPKCPADCESCVNSDTCTRCRQGLYLLSGRCHHVCP
EDYEPSDKLMECTPQVHCEVGEWSEWSPCSQSGRTCGFKRGQETRTRQVLRYPSPFGNPC
PDISEIKECLLKKRKCPGGRRKGERKERLNRNNRKDKENQTGEREDSDNRNKTEHRHRRG
HDPDLAWP
>Gasterosteus aculeatus_RSPO3(ENSGACP_8044)
MQLQLISFVLIILHGMDNTGCQQHSSPRNRQHKQISGVSSGCQQGGCLTCSDYNGCLSCK
PRFFMHLERIGMKQIGVCMTSCPLGFYGTRSPERNTCTKCRSECDSCFNKNFCTRCRAGF
YLHLGKCQENCPEGLVRSDTQRECVPGCPAECEACVNSETCARCRPGLYQLGGRCHHVCP
EDYEPSDKLMECTPQVHCDVGEWSEWSPCSRSGRTCGFKRGQETRTRQVLQHPSPFGNPC
AEVSEFKECLVKRRKCPERGQLGGQGTKNMNRGGRKKNERRERRNRNNRKDTGEREDLDN
RNKTEHRHRRGHDTDPASP
>Oryzias latipes_RSPO3(ENSORLP_7233)
MQLQVISFVLIILHCMDFTGCQPHSSSRHPQHKSISGVSSGCQQGGCLTCSDYNGCLSCK
PRFFMHLKRIGMKQIGVCMTSCPPGFYGTRSPERNTCTKCRSECDSCFDKNFCTRCRAGF
YLHLGKCQESCPDSMVHNDTQRECVLSCPAECELCVNSETCMRCRQGFYQLNGKCYHICP
EDYEPNDRLMECTPQVHCQVGEWSEWSPCIRSSKTCNRRGQEARMRQILQTPSQFGRPCP
LTTEVKDCLVKRKRCSGRRNPERKERRNRKNRKDKESDEGRREKKRGRERDRGTGERENS
ENRNKTEHRHRRGHNTETASP
>Strongylocentrotus purpuratus_(XP_796266)
MELEGFLFAITFFCGLLATMEGKHRGKGCPLGCSTCSVYNGCITCKPRYLFLLHRSGMKQVGICTHACPV
GFYPNSAGDYHRCSRCRIENCDTCYSRTFCSRCQPPYVGLYGKCVLQCPDSMYVNEMTSQCEVKVDCAVS
PWSPWSPCIKKGQTCGFKWGEHRRYREVVARPTPEAEPCPELFQGEKCRMHPRYCPGQLPRKPKDKGKRK
KEKGTTDNQEGTTRKNDGNKQKDRTNRRSKKKDRQKPSPRDERRQRQRKEEHLIDFPLSTRRTI
>Drosophila melanogaster_(FBpp0271811)
MLRHIVLLILLSSEVRGVCNRIPQGASGPRSPVDDNFKILIDGNPETYVPEHQYNVSLSC
PINMKFVSFTLVVEAEDPSAAFGGQDMTGHFELLGVGDTRFSTSCENMVENTNTNAKIYI
AVSWIAPRNPDSGCVLIKAGVVQHRDVWFLDDGFLTKRICPEEIDELNSLTPPLETCCAC
DEAKYEIVLERKWARNTHWKDFPSEDWRTRLGEVIGASHSHSYRYWAYGGRASKGMKELA
EHGATRTLENEIRENTQNGEVRTIIKAPGIPYRPKTFGTTLANARLDPVHHQISLAAKID
PSPDWILGVAGLELCLSNCTWLERKVLNLYPWDIGTDSGPSYMSSDEPQVPPDVVRRITS
SYPSDHRSPFYDDTGAPMKPLATLYLTRKKLYIRECEEVPQEGPLECAVHPWNEWTNCST
RCGQGYSHRQRSFKNPNLAANFNCDRRLEEFRQCQGTQCGAAEEELEGEEPGLGMENPPS
SGSMAECQLTNWGEWSPCTKTCGRGSSTRTRDYYNPQARQRCLSVMRIPLEETRECIGSD
CGGTIPDNGELDGFPEPDVFGETDHGGYMGKTTSWNSKQEHSSLGSGNQAWNRKPYNSWK
DKSLSNPRDNAQESPNLPFDQIENPQRPAYNPSDNMGGYDKGFPPTNSYSNDKLVGNRPG
YNDFNSDYNNKDAYNDYTTPSFTSRTPFGSRYPNQQETVEGNTNDINGNYNVVQDYCFEK
PYASTLPCFAKPVVESNYWFYDHEDHECKIFTTDNCDQNRNRFRTLTACEGTCLQPQINM
ERSENDAMDLYGRRSYDQKQTRGRPYDQTSGIAYGQTEGRSYDQKVGKSYDRTFGRSYKQ
TGGGSYDQPEDRSYDLSTGRSYVQPEDRSYDLSRGRSYDQPVGRSYDLAGGRSYGETSEA
GDIGEPMSQTRSRYDTSRRGRYGG
>Apis mellifera_(XP_016772377)
MPSSFSFDYPTFFDEFGPRPRQTTYHRQRNRGVPLQNLFTDPLFKEQWYLNGGAKDGYDMNLGPAWQKGY
TGKSVVVSILDDGIQTNHPDLALNYDHQASTDINDNDNDPMPRDNGDNKHGTRCAGEVAAVAFNQYCGVG
VAYNASIGGVRMLDGPVNDAVEARALGLNPDHIDIYSASWGPEDDGKTVDGPGPLARRAFIYGVTSGRKG
KGSIFVWASGNGGRHTDSCNCDGYTNSIFTLSISSATQGGYKPWYLEECSSTLASTYSSGTPGNDKSVAT
VDMDAKLRPDHICTVEHTGTSASAPLAAGIAALALEANPSLTWRDMQYLVVLTSRSTPLEKESGWILNGV
KRKVSHKFGYGLMDAGAMVNLAEQWTNVPPQHICKSDEINEERRIDPTYGYTLSVYMDVTGCAGSVNEVR
FLEHVQCKVSLRFFPRGNLRLLLTSPMGTTSTLLFERPRDVLSSSFDDWPFLSVHFWGEKADGRWTLQVN
NAGNRHVNSPGILKKWQLIFYGTATNPIRIRTRQFNPGYQGYPYVGAASNVQASVATLDGSSAPILTNRL
PGDTSSSSSFDSPPSSSQVGDESLDTARKILHDCDPQCDPQGCYGKGPTQCIACKNYRLDNTCVSQCPPR
SFPNQGGVCWPCHESCEICAGAGQDSCLSCAPAHLRVTDLAVCLQQCPEGYYENTENSTCVPCEANCASC
QDRPDKCTSCEHHLVMYENKCYAACPLYTYETQDYNCAPCHSTCETCNGTAENQCISCRPGLFSLNGACR
ASCPIGYGADKKRRECVPCPPGCATCDMSTCRSCDDGWSLNEEGLCAPEHRDRCKTTEFYENGHCKQCHA
SCKTCAGPGENNCISCQKPLLLQAKRCVYQCDDGYYSMAQPSGPVCVPCLHTCKTCVSRLNCTACQDGLQ
LQSGECRSSCAQGYYSDRGQCAKCYLACKTCSGPRRDQCVTCPGGWQLAAGECHPECPEGFFKSNFGCQK
CHHYCRTCKGRRNYRAGVTLLTPLLDGVNIERAIHTPGRDPCPDFIPETHRYDLHLSPFKFQSLNIHSIR
ISSPEKIQTMYINLSFI
>Trichoplax adhaerens_(XP_002110515)
MAEQLVKILLLFLTLIHIVRQESTEHYTNTWVIHVPGGLTNAKLVATTHASTILHQVGSLEDHYLIRHAG
TPHRSKRSNSYKSWNLRLDTRVLYVEQQISKLRIKRSFPNFNDPLWPKQWYLENTGQASGPPHLDHNIIP
AWKSGATGIGIVVSILDDGLYYEHPDLRRNYDPEASFDINGNDHDPTPRKTGNDENRHGTRCAGEVAAIA
NNSICTVGAAYNAKIGGIRMLDGDVTDAVEATSLSWKPQHIDIYSSSWGPEDDGRNIDGPGPLAKKAFID
GVNKGRHGLGSIFVWASGNGGSVHDNCNCDGYVISIYTISISAATDTGNVPWYTESCSSILATTFSSGNN
GQNKIITDDLHDRCTESHTGTSAAAPLAAGMFALALEANPRLTWRDLQHIVVITSKPDKLHTDDWTINGV
GRKISNWFGYGLLDAAALVSTARNWKTVPIQRSKSFKFKTKKNYIPPNGRLIVSINVEKSEAIVNYLEHV
QAVISLSHNQRGLITIQLISPAGTKSVLFDRRQQDTSRAGFKNWPLMTTHFWGEKSAGNWTLIIINKDSN
SGKLKGWKLVLFGTTSKPHDLYYSSCNPECERSSGCNGPGAADCRICRHFQAADGRCVKNCSNGQYGNLE
TKACINCPYGCDVCNNDSCITCKPNFANSNGSCVSSCPESTYQHSFNGNTKCLKCSSNCAACANETYCIS
CPGTAYEYRGSCIQQCPQGTYSNYVYGIRTCTSCKHNCLDCYGNEAGSCRVCQKGYQLVVDRSKCTKSCP
VGYYNAISGEQNICLACHHRCTSCLSAASSGCKSCSHGFHLYNGSCTDKCPDGTYTDKFTGECFPCFNTC
TTCNAGKSKSCLSCKSNLYLQNGECVSNCFKGYYQDDNLMRCRRCHHSCASCNGPSSNSCTSCKLSQSFL
HNNSCLMECPVGHYSDITMKACNPCSSHCYHCVNSSVCLSCNKNFILHHQKCAKSCPSGYILKERTCNPC
HPTCSNCSDDDIASCSGCKSHTHFLHQGICTKSCLFGYFGDTITQQCQPCHSSCASCFGEGNSSCLLCPL
GRFLQHGSCVTTCNNGFPGKNGTCSSCEGVGCRECLPNDPNQCLTCLDNYFNHKFNCVRECPVGTYTNAT
AGQCLICHDSCNTCSGKHIENCTDCKPGWFMHAGKCVSYCPSGSYANGNACSKCSHGCKLCISQNTCLEC
ESSLVKFNGSCLKDCPSNSYATDENTECQLCHKGCETCKIVNRESQCLSCINQYLILKAGKCLPNGNCSG
NMYFNGSNCSKCHSDCEACFDDDRISCLRCREDKYLNPVSAICEQYCPLGYFADNATRRCQQCHYSCLSC
SNASVCTQCRPGFYNSSGNCITKCASGEYFNNKTASCQLCGNNCKECNINSKTCITCKSGNYKYDGICLS
ACPTQTYASNGNCKACPSGCLECKADMTCTKCKNNYKLSQSACVLSLPNGCKNSSCLVCKVANCSRCSPS
DSTICNICIKPFILHQGSCIKQCPDGTYFDHVKKNCFDCNDSCSSCVGPKETDCVKCSSAKPYLLHYKCL
SKCPANYYIDNANAKCRQCHFSCKSCSGGSMNDCIICSDGFHYLKSEKQCVNKCPDLSYYRKNETDCGSC
YSGCASCYGNEKDKCISCISPMVNFNFECMEKCPLGSYNDSGICRKCHPSCGSCTGPHLNQCTSCSTGLF
LKNGECHGTCPSGYYEDMKSLKCLPCNPSCKTCVSDSAQCLTCNHGMVLQNSKCLRNCSSGYYHTDGGCR
PCHTSCLSCKGFTASDCLSCSKGWELLPHGICEPVCPSGQYYDIGLKSCGNCHSSCATCSSKQSASCLSC
LKGRLLDKQSSRCYPCCKIDSDSQCCNCSASLKVCVLLSDTGNNIVTTPSLVTVTHHDFGNTFKEEKPVQ
LILISGAISLLLFGVVVIIRCRRNIFGHRGYKKLTPSGYDHTTISSTRTAYPDYDNDEINQV