>Homo_sapiens_ADRA1A
--------------------------------------------------------------------------------
--------------------------------------------------------MVFLSGNASD--------------
--SSNCTQPP-----------------------------------------------------------APVNISKAILL
GVILGGLILFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVLPFSAIFEVLG------YWAFGRV-FCNI
WAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP-TIVTQRRGLMALLCVWALSLVISIGPLFGWRQP------------
--------------------------------------------------------------------------------
-------------------------APEDETICQINEEPG---YVLFSALGSFYLP-LAIILVMY-------CRVYVVAK
--------------------------------------------------------------------------------
------------------RESRGLKSGLKTD-------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KSDSEQVTLRIHRKNAPAGG-----
--------------------------------------------------------------------------------
------------SGMASAKTKTHFSV-------------------------------------------RLLKFSREKKA
AKTLGIVVGCFVLCWLPFFLVMPIG--SFFPDFK--------PSETVFKIVFWLGYLNS--------CINPIIYPCSSQE
--------------FKKAFQNVLR-IQCLCRKQSS--------KHALGYTLHPPSQAVE------GQHKDMVRIPVGSRE
TFYRISKTDGV------------------CEWKFFSSMPRGSARITVSKDQSSCTTARTKSRSVTRLECSGMILAHCNLR
L--PGSRDSPASASQAAGTTGMCHQADATRPS------------------------------------------------
------------------------------------
>Mus_musculus_ADRA1A
--------------------------------------------------------------------------------
--------------------------------------------------------MVLLSENASE--------------
--GSNCTHPP-----------------------------------------------------------AQVNISKAILL
GVILGGLIIFGVLGNILVILSVACHRHLHS-VTHYYIVNLAVADLLLTSTVLPFSAIFEILG------YWAFGRV-FCNI
WAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP-TIVTQRRGVRALLCVWALSLVISIGPLFGWRQQ------------
--------------------------------------------------------------------------------
-------------------------APEDETICQINEEPG---YVLFSALGSFYVP-LTIILVMY-------CRVYVVAK
--------------------------------------------------------------------------------
------------------RESRGLKSGLKTD-------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KSDSEQVTLRIHRKNVPAEG-----
--------------------------------------------------------------------------------
------------SGVSSAKNKTHFSV-------------------------------------------RLLKFSREKKA
AKTLGIVVGCFVLCWLPFFLVMPIG--SFFPNFK--------PPETVFKIVFWLGYLNS--------CINPIIYPCSSQE
--------------FKKAFQNVLR-IQCLRRRQSS--------KHALGYTLHPPSQAVE------GQHRGMVRIPVGSGE
TFYKISKTDGV------------------REWKFFSSMPQGSARITMPKDQSACTTARVRSKSFLQVCCCVGSST-----
---PRPEENHQVPTIKIHTISLGENGEEV---------------------------------------------------
------------------------------------
>Monodelphis_domestica_ADRA1A
--------------------------------------------------------------------------------
--------------------------------------------------------MVFFPENASD--------------
--SSNCTHAQ-----------------------------------------------------------EPVNISKAILL
GVILGSLILFGVLGNILVILSVACHRHLQS-VTHYYIVNLAVADLLLTSTVLPFSAILEILG------YWAFGRI-FCNI
WAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYP-TIVTQKRGLLALMCVWALSLTISIGPLFGWKEQ------------
--------------------------------------------------------------------------------
-------------------------PPEDETICQITEEPG---YVLFSALGSFYIP-LAIILVMY-------CRVYVVAK
--------------------------------------------------------------------------------
------------------RESKGLKHGLKTD-------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KSDSEQVTLRIHRKNIPSAS-----
--------------------------------------------------------------------------------
------------SSGSSSKNKTHFSV-------------------------------------------RLLKFSREKKA
AKTLGIVVGCFILCWLPFFLVMPIG--SFFPESK--------PSDTVFKIAFWLGYLNS--------CINPIIYPCSSQE
--------------FKKAFQNVLR-AQCLRRKQST--------KHAIGYTLNPPSHAI-------GEHKDLVRIPVGSGE
TFYKISKSEGV------------------CEWKFFSSTSSGPTRNAVTHDQSTCTSARVRSKSFLRVCCCVGSSG-----
---PAIQENRQLPTIKIHTISLSENGEEVS--------------------------------------------------
------------------------------------
>Gallus_gallus_ADRA1A
--------------------------------------------------------------------------------
--------------------------------------------------------MVFLPGNSSN--------------
--CSNCTYSA-----------------------------------------------------------EPVNISKAILL
GVILGGLIIFGVLGNILVILSVACHRHLQS-VTHYYIINLAVADLLLTSTVLPFSATMEILG------YWAFGRI-FCNI
WAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYP-SIVTEKRGLLALLCVWALSLVISIGPLFGWKEP------------
--------------------------------------------------------------------------------
-------------------------APEDETICQITEEPG---YVLFSALGSFYLP-LTIILVMY-------CRVYVVAK
--------------------------------------------------------------------------------
------------------RENKGLRSGLKME-------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KSRSEAVTLRIHRKNVPENS-----
--------------------------------------------------------------------------------
------------GATASSKSKHHFSV-------------------------------------------RLLKFSREKKA
AKTLGIVVGCFVLCWLPFFVVMPLG--SFFPTIK--------PPDTLFKITFWLGYLNS--------CINPIIYPCSSQE
--------------FKKAFQNVLR-AQCLPRKHAAK-------KQSPSFNLNHPSNQSM------GGGKGVVRIPVGSGE
TFYKISKSDGV------------------CEWKIFSAVQSVPTKSAIPKDKSSCTAAKVKSKGFLQECCCAGTSG-----
---NTVHENCKVPTIKIHTMSLSESGEDV---------------------------------------------------
------------------------------------
>Pelodiscus_sinensis_ADRA1A
--------------------------------------------------------------------------------
--------------------------------------------------------MVFLPGNSTD--------------
--CSNCTQTV-----------------------------------------------------------GITDNLKAILL
GVILGGLIVFGVLGNILVILSVACHRHLQS-VTHYYIINLAVADFLLTSTVLPFSATFEILG------YWVFGRI-FCNI
WAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYP-AIMTEKRGLMALLCVWALSLVISIGPLFGWKEP------------
--------------------------------------------------------------------------------
-------------------------APEDETICQITEEPG---YVLFSAFGSFYLP-LTIILVMY-------CRVYVVAK
--------------------------------------------------------------------------------
------------------RESKGLTSGLKTE-------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KSHSEEVTLRIHCKNTSTGS-----
--------------------------------------------------------------------------------
------------GSTPSTKNKTHFSV-------------------------------------------RLLKFSREKKA
AKTLGIVVGCFILCWLPFFIVMPIG--VFFPAIK--------PSKTVFKITFWLGYLNS--------CINPIIYPCSSQE
--------------FKKAFQNVLR-AQCLSKKQAAS-------KHSLSFNLNHPASHSM------DSTKNVVRIPVGSGE
TFYRISKSEGV------------------CEWKIFSTVQSMATKSAISKDKSSCTRAKVKSKGFLRTCCCAGTSG-----
---SVGRDNHNVPTIKIHTISVSENGEDV---------------------------------------------------
------------------------------------
>Xenopus_tropicalis_ADRA1A
--------------------------------------------------------------------------------
--------------------------------------------------------MVILYENNTVESIQL---------
--CLNCTHPG-----------------------------------------------------------ATINISKAIVV
GVIFGVFITFGVLGNILVILSVACHRHLQT-VTHYFIANLAVADLLLMSMVLPFSATFEIQG------YWLFGRI-FCNI
WAAVDVLCCTASIMSLCAISIDRYIGVSYPLRYP-SIMTEKRGVLALLCIWVLSLVISIGPLFGWKQP------------
--------------------------------------------------------------------------------
-------------------------APEDDKICEITKEPG---YALFSAFGSFYLP-LSIILVMY-------FRVYIVAK
--------------------------------------------------------------------------------
------------------RESKVLTSGMKLE-------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KSDSEEVTLRIHRKSTPESI-----
--------------------------------------------------------------------------------
------------GSTSSSKQKTHFSV-------------------------------------------RLLKFSREKKA
AKTLGIVVGCFVLCWLPFFLVMPIAG-SIYPPAN--------SSDTIFKITFWLGYFNS--------CINPVIYPCSSPE
--------------FRKAFQNILH-ARCSHRRQAAS-------KYSSGFLLNSPVHRSS------EENKNVVRIPVGSGE
MFYRISKSDEG------------------CEWKYFTPLPSPATPYGTPRDFANCSSARVSSKSFLRTCCCVGTQQ-----
-----TRSCHDVPTIKIHTISVSENGEAV---------------------------------------------------
------------------------------------
>Danio_rerio_ADRA1A_a
--------------------------------------------------------------------------------
----------------------------------------------------------MVFGNAQN--------------
--CSNCSQVL----------------------------------------------------------VPELNVMKAVAL
GVVLAIFIVFGVLGNILVILSVACHRNLRT-VTHYFIVNLAVADLLLSSTVLPFSTVFEMLG------RWIFGRP-FCDV
WAAMDVLCCTASIMSLCVISVDRYIGVSYPLQYP-SIVTERRALLALIALWVLSITISIGPLFGWKEP------------
--------------------------------------------------------------------------------
-------------------------APDDESICKITEEPG---YAIFSALGSFYLP-LVVILSMY-------CRVYVVAR
--------------------------------------------------------------------------------
------------------RETRGLISGQKTE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KSDHAETVTLRIHRGNMTVS------
--------------------------------------------------------------------------------
-------------EDEALRNRTHFAL-------------------------------------------RLLKFSREKKA
AKTLGIVVGCFVLCWLPFFLVLPIDLGSIFPTYR--------PSDTVFKITFWLGYFNS--------CINPIIYPCSSQE
--------------FKKAFLSVLG-ARCLRKRSTP--------SHTLYQSHSPRHGQS--QILGLSSRDNPSRLSPSSSI
ALSRSPSSRDG------------------RDWQAPSRTSSVGTTGVSTGVSVGAKMAGMCGKNLLRTCCCVR-ADSPQPE
P-----PAQNSLPVIKIHQLSLCEDGDAV---------------------------------------------------
------------------------------------
>Homo_sapiens_ADRA1B
--------------------------------------------------------------------------------
-----------------------------------------------------MNPDLDTGHNTSAPAHWGE-----LKN
ANFTGPNQTSSNST------------------------------------------------------LPQLDITRAISV
GLVLGAFILFAIVGNILVILSVACNRHLRT-PTNYFIVNLAMADLLLSFTVLPFSAALEVLG------YWVLGRI-FCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYP-TLVTRRKAILALLSVWVLSTVISIGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------APNDDKECGVTEEPF---YALFSSLGSFYIP-LAVILVMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------MSN-SKELTLRIHSKNFHEDTLSST-
--------------------------------------------------------------------------------
--------------KAKGHNPRSSIAV------------------------------------------KLFKFSREKKA
AKTLGIVVGMFILCWLPFFIALPLG--SLFSTLK--------PPDAVFKVVFWLGYFNS--------CLNPIIYPCSSKE
--------------FKRAFVRILG-CQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQR
TLPS-ASPSP--------GYLGRG-APPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTE---PESPG
TDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF----------------------------------------------
------------------------------------
>Mus_musculus_ADRA1B
--------------------------------------------------------------------------------
-----------------------------------------------------MNPDLDTGHNTSAPAHWGE-----LKD
ANFTGPNQTSSNST------------------------------------------------------LPQLDVTRAISV
GLVLGAFILFAIVGNILVILSVACNRHLRT-PTNYFIVNLAIADLLLSFTVLPFSATLEVLG------YWVLGRI-FCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYP-TLVTRRKAILALLSVWVLSTVISIGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------APNDDKECGVTEEPF---YALFSSLGSFYIP-LAVILVMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------MSN-SKELTLRIHSKNFHEDTLSST-
--------------------------------------------------------------------------------
--------------KAKGHNPRSSIAV------------------------------------------KLFKFSREKKA
AKTLGIVVGMFILCWLPFFIALPLG--SLFSTLK--------PPDAVFKVVFWLGYFNS--------CLNPIIYPCSSKE
--------------FKRAFMRILG-CQCRGGRRRRRRRR--LGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQR
TLPS-ASPSP--------GYLGRG-TQPPVELCAFPEWKP-GALLSLP--EPPGRRGRLDSGPLFTFKLLGE---PESPG
TEGDASNGGCDTTTDLANGQPGFKSNMPLAPGHF----------------------------------------------
------------------------------------
>Monodelphis_domestica_ADRA1B
--------------------------------------------------------------------------------
-----------------------------------------------------MNPHLDVSHNISAPAYWEE-----PSV
GNLTGPNQTSSYST------------------------------------------------------PPELDIRRAISV
GIVLGAFILFAIVGNILVILSVACNRHLRT-PTNYFIVNLAIADLLLSFTVLPFSAALEVLG------YWVLGRI-FCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYP-TLVTRKKAILALLSVWVLSMVISIGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------APKDEKECGVTEEPF---YALFSSLGSFYIP-LTVILVMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------MSN-SKELTLRIHSKNFHEDALSST-
--------------------------------------------------------------------------------
--------------KVKGHNPRNSIAV------------------------------------------KLFKFSREKKA
AKTLGIVVGMFILCWLPFFIILPLG--SLFATLK--------PPDTVFKVVFWLGYFNS--------CINPIIYPCSSKE
--------------FKRAFLRILK-CQCHRRNR--------LGWWNYNYRAWNRG-SFE--QSRKDSLDDSGSCLSGSQR
TLNS-ATPSP--------GYLSKV-THPQVEMYTFSEWKSSGTFLSPPHPEPPGR--HRDTGHLFTLKYLAE---HEG--
HPGLDSNGGCEVAANMANGQAGFKKNMPLGPSQF----------------------------------------------
------------------------------------
>Gallus_gallus_ADRA1B
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------N
LSANSSNETTSNLD------------------------------------------------------SPTLDISRAITV
GLILGAFILFAIIGNILVILSVACNRHLRI-PTNYFIINLAIADLLLSFTVLPFSATLEILG------YWVLGRI-FCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYP-TLVTRRRAILALLGVWVLSMVISIGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------APKDDKECRITEEPF---YALFSSLGSFYIP-LIVILVMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------MSN-SKELTLRIHYRNIHEDTLNSN-
--------------------------------------------------------------------------------
--------------KSKGHNSRNSLAL------------------------------------------KLLKFSREKKA
AKTLGIVVGMFILCWLPFFIVLPLG--SLFSALK--------PPEIVFKVIFWLGYFNS--------CLNPIIYPCSSKE
--------------FKRAFIQILK-CQCHRRKQ--------SGWWAYSYRNWNRC---SFEHPRKDSLEDSGSFLSGSQR
TLSS-ASPSP--------GYLSKI-THPHMEMCTFQEWKNPSSFLSPL----QEGSRQKDPCQFFTFNLLTERN-GHIAA
SSQASSNGDHEDIFDTVNGKTDCRTNIMLE--------------------------------------------------
------------------------------------
>Danio_rerio_ADRA1B_a
--------------------------------------------------------------------------------
------------------------------------------------------------------------------SD
VSNSNSSGNGTAPS------------------------------------------------------S--FSLSRALPL
GMVLGAFIVFAIVGNILVILSVVCNRHLRI-PTNYFIINLAMADLLLSTTVLPVSATREILN------YWVFGRI-FCDI
WAAVDVLCCTASIMSLCVISIDRYIGVRYPLQYP-SIVTEKRALLAMLGVWVLAFVISIGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------PSEDDTVCLITEEPF---YALFSSLGSFYIP-LAVILAMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RMD-SNELTLRIHYKGSQTQEDC---
--------------------------------------------------------------------------------
----------SKG------HLRSSLTV------------------------------------------KLLKFSREKKA
AKTLGVVVGMFILCWLPFFLALPIG--SFNTSLR--------PPETFFKVIFWLGYFNS--------CLNPIIYPCYSRE
--------------FKQAFIRILR-CQCQQKKQQ--------GWRAYNYRVPNANHVYSDTS---------SICMNGSLQ
TLAP-SQPSPT----LFSRVVGSR-PASGLLPGWGPCTSSSSSSLSGSPFPGMMRSGSQATSPCKSNRMALLFPNGQNGK
--------------------------------------------------------------------------------
------------------------------------
>Danio_rerio_ADRA1B_b
--------------------------------------------------------------------------------
--------------------------------------------------MNPQNEYAVTRSWGSTILDAFE------GS
AVFPNFSLKLNGTG------------------------------------------------------LEPLLLSRAVPL
GLVLGFFITFAIAGNILVILSVVCNRHLRS-PTNYFIVNLAIADLLLGTTVLPVSATLEVVG------HWVFGRI-FCDV
WAAVDVLCCTASIMSLCVISIDRYIGVSHPLQYP-NIVTGRRALLAMLGVWVLSLVISIGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------PSPDDTVCAINEEPF---YALFSSLGSFYIP-LIVILVMY-------CRVYVVAK
--------------------------------------------------------------------------------
------------------MTTKNLEAGVKTE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------SMN-SGEITLRIHRGSQVHEDAGKS-
--------------------------------------------------------------------------------
----------------RAHQARNSLTV------------------------------------------KLLKFSREKKA
AKTLGVVVGMFTLCWLPFFLTLPIV--SFNTSLR--------PPETVSSIIFWLGYFNS--------CLNPIIYPCYSRE
--------------FKLAFIRILK-CRCHRRRRP--------GWRAYNYRGSQIN-SFYSRQDSRDSVN-YGSYLNGSQR
TLSS-SSPSP--------SYHTKG-LSHFQEDGPRLGRSRTPSVLSESILDHHLEPVEEDPRQTVSIQDHAGVSELASKA
SE------------------------------------------------------------------------------
------------------------------------
>Takifugu_rubripes_ADRA1B_a
--------------------------------------------------------------------------------
-------------------------------------------------MSLSTDNVTFLWKNDSTQLDNAS------SR
VNFSSS-AGGNHTA------------------------------------------------------LNEVRLTRAIPL
GLVLGAFIVFAIAGNILVILSVVCNRHLRT-PTNYFIINLAIADLLLSTTVLPVSATLEILN------YWVFGRI-FCDI
WAAVDVLCCTASIMSLCVISIDRYIGVSHPLQYP-GIVTEKRALLAMLGVWALSVVISIGPLFGWKQP------------
--------------------------------------------------------------------------------
-------------------------PSPDDTECPITEEPF---YALFSSLGSFYIP-LVVILAMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RMN-SSELTLRIHKGCQVHEEPGHS-
--------------------------------------------------------------------------------
-----------GTGKGRAHQARSSLTV------------------------------------------KLLKFSREKKA
AKTLGVVVGMFTLCWLPFFLALPIG--SFNVNLR--------PPEILFKVIFWLGYFNS--------CLNPIIYPCYNRE
--------------FKLAFIRILR-CQCHQRKRP--------GFKAYNYRTSNISASGHSRKGSADHN---SSCLNGSQR
TLPSSASPSP--------SYLSRG-LPT----------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Takifugu_rubripes_ADRA1B_b
--------------------------------------------------------------------------------
--------------------------------------------------------RLSSAFGMSLWTNRSS------AG
PMGSNSSINGSQPG------------------------------------------------------AAPLDLSRAVPV
GMVLAFFIMFAIVGNILVILAVVCNRHLRI-PTNYFIINLAIADLLLGTTVLPVSATLEVLD------YWVFGRI-FCDI
WAAVDVLCCTASIMSLCAISIDRYIGVRYPLQYP-MIVTEQRALLAMLGVWILSIVISIGPLLGWKQP------------
--------------------------------------------------------------------------------
-------------------------PSQDDTVCVITQEPF---YALFSSLGSFYIP-LAVILAMY-------FRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------SQENSNELTLRIHCRNQQIQDLCPS-
--------------------------------------------------------------------------------
----------SKGGSGGSSAGRSTLTV------------------------------------------KLLKFSREKKA
AKTLGVVVGMFILCWLPFFLALPIG--SFNPSLR--------PPETFFKVIFWLGYFNS--------CLNPIIYPCYSRE
--------------FKQAFIRILQ-CQWKRKRQR---------WQAY----PNYRRHQGSNN---------SSFLNSSQQ
ALSS-VSPST--------QYVTSR-PHP----------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Tetraodon_nigroviridis_ADRA1B_a
--------------------------------------------------------------------------------
-------------------------------------------------MSLGTDNVTFLWKNDSTELDNAS------SR
VNFSS---GGNHSA------------------------------------------------------LSELRLSRAIPL
GLVLGAFIVFAIAGNILVILSVVCNRHLRT-PTNYFIINLAIADLLLSTTVLPVSATLEILN------YWVFGRI-FCDI
WAAVDVLCCTASIMSLCVISIDRYIGVSHPLQYP-GIVTEKRALLAMLGVWALSVVISIGPLFGWKQP------------
--------------------------------------------------------------------------------
-------------------------PSPDDTVCPITEEPF---YALFSSLGSFYIP-LVVILAMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RMN-SSELTLRIHKGSQVNEESGHAA
TA------------------------------------------------------------------------------
--------TGTGTGKGRAHQARSSLTV------------------------------------------KLLKFSREKKA
AKTLGVVVGMFTLCWLPFFLALPIG--SFNVNLR--------PPEILFKVIFWLGYFNS--------CLNPIIYPCYSRE
--------------FKLAFIRILR-CRCQQRKRP--------GFQAYSHRSSNISSSGHSRKGSADHN---SGCLNGSQR
TLPSSASPSP--------SYLGGA-LPP----------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Tetraodon_nigroviridis_ADRA1B_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------QVLD------YWVFGRI-FCDI
WAAVDVLCCTASIMSLCVISIDRYIGVRYPLQYP-MIVTEKRALLAMLGVWILAIVISIGPLLGWKQP------------
--------------------------------------------------------------------------------
-------------------------PSQDDTVCLITEEPF---YALFSSLGSFYIP-LAVILAMY-------FRVYIVAK
--------------------------------------------------------------------------------
------------------RTTKNLEAGVMKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------SQENSSELTLRIHCRNQQIQDICPS-
--------------------------------------------------------------------------------
----------SKGGSSGSSAGRSTLTI------------------------------------------KLLKFSREKKA
AKTLGVVVGMFILCWLPFFLALPIG--SFNSSLR--------PPDTFFKVIFWLGYFNS--------CLNPIIYPCYSRE
--------------FKQAFIRILR-CQWKRKHQR---------WQAY----HNYRHHQGSKN---------SSFLSSSQQ
TLSS-VSPSP--------QYATSR-PRPPAWP----------RPAGGKLHLGSTRQGR----------------------
--------------------------------------------------------------------------------
------------------------------------
>Oryzias_latipes_ADRA1B_a
--------------------------------------------------------------------------------
-----------------------------------------------------TNNVTNLWKNGSSELNWET------LQ
INFTNG-SGGEHRE------------------------------------------------------AGKVDLTRAIVL
ALVLGAFIVFAIAGNILVILSVVCNRHLRT-PTNYFIINLAMADLLLGTTVLPVSATKEILN------YWVFGRI-FCDI
WAALDVLCCTASIMSLCVISIDRYIGVSHPLQYP-GIVTEKRALLAMLGVWVLSVVISIGPLLGWKQP------------
--------------------------------------------------------------------------------
-------------------------PSDDDMECLITEEPF---YALFSSLGSFYIP-LAVILAMY-------CRVYIVAK
--------------------------------------------------------------------------------
------------------RTTRNLEAGVMRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RMN-TSELTLRIHKGSQMHEEPGTS-
--------------------------------------------------------------------------------
-----------NAGKGRGHQARSSLTV------------------------------------------KLLKFSREKKA
AKTLGVVVGMFILCWLPFFLTLPLG--SFNENLR--------PPELLFRVIFWLGYFNS--------CLNPIIYPCYSRE
--------------FKLAFIRILR-CQCHQQKRP--------SWRAYNYRSSNFSSSGNSRKSSTDHT---SSWLNGSQG
TLPSSASPSP--------SYLSSG-LPP----------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Branchiostoma_floridae_ADRA1B
--------------------------------------------------------------------------------
--------------------------------------------------------MDGLPLDN---FTFDD------NG
TFNVTEVEDQSQVL------------------------------------------------------GLRMSLTASVLV
GTVLSCICLLTIAGNILVVLAVCLERSLRT-NIGYFYINLAIADLLLGCLVLPFSAARELLN------YWPFGEA-LCEL
WAAVDVLCCTASIFSLCSISLDRYIGVTRPLHHN-MIVTKRRVVVILVAVWAISAAISVGPLFGWKHP------------
--------------------------------------------------------------------------------
-------------------------KSYQNSQCNINGSPS---YIIFSVVGSFYVP-AFIVLYVY-------RQVYRAA-
----V---------------------------------------------------------------------------
------------------RETSKLMITLKAQE------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------DRNPASAESVRIHRGKTVTAESRQSP
P-------------------------------------------------------------------------------
-----------RLSPNSSKPRMVKEALGSVK-------------------------------------NRIEKFTKEKKA
AKTVGIIVGVFLVCWLPFFIMYPID--SMIVK----------VPELLITMAFWLGYCNS--------FLNPIIYACSNGH
--------------FRRAFRRVLL-CGKRQ-----------------SRFPTMRS-----------EDYTLS--------
--------------------------SRSSCRRVHSN----------YS--SQGSSKRQQLKIQLQELTVS---------
--------------------------------------------------------------------------------
------------------------------------
>Homo_sapiens_ADRA1D
------------------------------------------------------------------------------MT
FRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGG---GGGVVGAGSGEDNRSSAGEPGSA----
--GAGGDVNGTAAV------------------------------------------------------GGLVVSAQGVGV
GVFLAAFILMAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLG------FWAFGRA-FCDV
WAAVDVLCCTASILSLCTISVDRYVGVRHSLKYP-AIMTERKAAAILALLWVVALVVSVGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------VPPDERFCGITEEAG---YAVFSSVCSFYLP-MAVIVVMY-------CRVYVVAR
--------------------------------------------------------------------------------
------------------STTRSLEAGVKRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RGK-ASEVVLRIHCRGAATGADGAHG
--------------------------------------------------------------------------------
------------MRSAKGHTFRSSLSV------------------------------------------RLLKFSREKKA
AKTLAIVVGVFVLCWFPFFFVLPLG--SLFPQLK--------PSEGVFKVIFWLGYFNS--------CVNPLIYPCSSRE
--------------FKRAFLRLLR-CQCRR-RRRRRPLW---RVYGHHWRASTSGLRQDCAPSSGDAP-------PGAPL
ALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAAC-AQRSEVEA
VSLGVPHEVAEGATCQAYELADY---SNLRETDI----------------------------------------------
------------------------------------
>Gorilla_gorilla_ADRA1D
------------------------------------------------------------------------------MT
FRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGG---GGG------------------------
---------GVVAV------------------------------------------------------GGLVVSAQGVGV
GVFLAAFILMAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLG------FWAFGRA-FCDV
WAAVDVLCCTASILSLCTISVDRYVGVRHSLKYP-AIMTERKAAAILALLWVVALVVSVGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------VPPDERFCGITEEAG---YAVFSSVCSFYLP-MAVIVVMY-------CRVYVVAR
--------------------------------------------------------------------------------
------------------STTRSLEAGVKRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RGK-ASEVVLRIHCRGAATGADGAHG
--------------------------------------------------------------------------------
------------MRSAKGHTFRSSLSV------------------------------------------RLLKFSREKKA
AKTLAIVVGVFVLCWFPFFFVLPLG--SLFPQLK--------PSEGVFKVIFWLGYFNS--------CVNPLIYPCSSRE
--------------FKRAFLRLLR-CQCRR-RRRRRPLW---RVYGHHWRASTSGLRQDCAPSSGDAP-------PGAPL
ALTALPDPDPE--------------RKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAAC-AQRSEVEA
VSLGVPHEVAEGATCQAYELADY---SNLRETDI----------------------------------------------
------------------------------------
>Mus_musculus_ADRA1D
------------------------------------------------------------------------------MT
FRDILSVTFEGPRASSSTGGSGAGGG----AGTVGPEGPAVGGVP----GATGGSAVVGTGSGEDNQSSTAEAGAA----
--ASG-EVNGSAAV------------------------------------------------------GGLVVSAQGVGV
GVFLAAFILTAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSAAVLPFSATMEVLG------FWAFGRT-FCDV
WAAVDVLCCTASILSLCTISVDRYVGVRHSLKYP-AIMTERKAAAILALLWAVALVVSVGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------VPPDERFCGITEEVG---YAIFSSVCSFYLP-MAVIVVMY-------CRVYVVAR
--------------------------------------------------------------------------------
------------------STTRSLEAGIKRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------PGK-ASEVVLRIHCRGAATSAKG-NP
G-------------------------------------------------------------------------------
------------TQSSKGHTLRSSLSV------------------------------------------RLLKFSREKKA
AKTLAIVVGVFVLCWFPFFFVLPLG--SLFPQLK--------PSEGVFKVIFWLGYFNS--------CVNPLIYPCSSRE
--------------FKRAFLRLLR-CQCRR-RRRR--LW---RVYGHHWRASTGDPRSDCAPSPRIAP-------PGAPL
ALTAHPGPGSV--DTPEAQASVSGRRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKFRSGGARRAETAC-ALRSEVEA
VSLNVPQDGAEAVICQAYEPGDL---SNLRETDI----------------------------------------------
------------------------------------
>Canis_familiaris_ADRA1D
------------------------------------------------------------------------------MT
FRDLLIVSFEGPRPDGSAGGSSAGGCGGGAGGAAASEGPAVGGVPGAALGG--GGGVMGACVGQDNRSSAGEPGGA----
--GTGGEVNGTAAV------------------------------------------------------WGLVVSAQGVGV
GVFLAAFILTAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLG------FWAFGRA-FCDV
WAAVDVLCCTASILSLCTISVDRYVGVRHSLKYP-AIMTERKAAAILALLWAVALVVSVGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------VPPDERFCGITEEAG---YAVFSSVCSFYLP-MAVIVVMY-------CRVYVVAR
--------------------------------------------------------------------------------
------------------STTRSLEAGVKRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RGK-ASEVVLRIHCRGAS-AADGAHG
--------------------------------------------------------------------------------
------------PRSAKGHTFRSSLSV------------------------------------------RLLKFSREKKA
AKTLAIVVGVFVLCWFPFFFVLPLG-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Equus_caballus_ADRA1D
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------VGV
GVFLAAFILTAVAGNLLVILSVACNRHLQT-VTNYFIVNLAVADLLLSATVLPFSATMEVLG------FWAFGRA-FCDV
WAAVDVLCCTASILSLCTISVDRYVGVRHSLKYP-AIMTERKAAAILALLWAVALVVSVGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------VPPDERFCGITEEAG---YAVFSSVCSFYLP-MAVIVVMY-------CRVYVVAR
--------------------------------------------------------------------------------
------------------STTRSLEAGVKRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RGK-ASEVVLRIHCRGASLGADGAHG
--------------------------------------------------------------------------------
------------MRSAKGHTFRSSLSV------------------------------------------RLLKFSREKKA
AKTLAIVVGVFVLCWFPFFFVLPLG--E----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Gallus_gallus_ADRA1D
------------------------------------------------------------------------------MT
FPELSNGSLSENRTGQGSQSGANRSWGLQ---------------------------------------------------
--GEESPEGN-GTT------------------------------------------------------LPFALDVQAVGV
GVFLAVFILSAIVGNILVILSVACNRHLQT-VTNYFIVNLAIADLLLSTTVLPFSATLEVLG------FWVFGRI-FCNI
WAAVDVLCCSASIMSLCIISVDRYIGVKYSLKYP-TIMTERKAGVILVVVWLSSMVISIGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------PPPDESICSITEEPG---YALFSSLFSFYLP-LMVILVMY-------FRIYVVAR
--------------------------------------------------------------------------------
------------------RTTRSLEAGVKKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RNK-SMEVVLRIHCRSVLEEP----L
S-------------------------------------------------------------------------------
------------STQSKGHNFRSSLSV------------------------------------------RLLKFSREKKA
AKTLAIVVGVFILCWFPFFFVLPFG--SFFPSLK--------PSEMVFKVIFWLGYFNS--------CVNPIIYPCSSKE
--------------FKRAFIRLLK-CQCHR---RRRPIW---RVYDHHWRGASVNSSVQDSETDLRPR------------
-----ISTLNSSFIFNSSLQERAGKRRTLSFKGWKMLTPFQKPASAQLKEKMNSLSNKIRGGSSKGGVTAT--YKTEVES
VSIGIPHDFMETIDYQTYD-LTD--CCGLRETDI----------------------------------------------
------------------------------------
>Anolis_carolinensis_ADRA1D
------------------------------------------------------------------------------MT
FSDRINASLNGNHSGEAGGINGTLPSG-----------------------------------------------------
--GEEDVQANNSTS------------------------------------------------------LALKLTLQSVSV
GVFLALFILSAIVGNILVILSVACNRHLQT-VTNYFIINLAIADLLLSTTVLPFSATLEVLED-----LWVFGRI-FCDI
WAAVDVLCCTASIMSLCIISVDRYIGVKYSLKYP-TIMTEKKAVIIMVAVWISSMVISIGPLLGWKEA------------
--------------------------------------------------------------------------------
-------------------------PPENDQHCNITEEPG---YAIFSSLFSFYLP-LAVILVMY-------FNIYVVAR
--------------------------------------------------------------------------------
------------------RTTKSLEAGVKKE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RSK-SMEVVLRIHCRSVVEDS----Q
A-------------------------------------------------------------------------------
------------STKNKGHTFRSSLSV------------------------------------------RLLKFSREKKA
AKTLAIVVGVFILCWLPFFFVLSFG--SYFPSVK--------PEGMSFKIIFWLGYFNS--------CVNPIIYPCSSKE
--------------FKRAFIRLLK-CQCRR---RRRPIW---RVYDNHWRGASVNGSGQDSERDLQSR------------
-----VSTTNGSFILNSSSLESSSKRRTLNFKRWRMFSPFQKP--TQLKEKMNSLSNKIRGGSIKGGVSAS--YKTEVES
VSIGIPNEFMECIDYQVYDDLTDSESSGLKETDI----------------------------------------------
------------------------------------
>Takifugu_rubripes_ADRA1D_a
--------------------------------------------------------------------------------
-------------------QLSPAGTKVI---------------------------------------------------
--SINLLLLNRCPR------------------------------------------------------CFLSSPCWIKRL
GFVLSAFILVAIVGNILVILSVVCNKHLQT-VTNFFIVNLAMADLLLSIIVLPFSASLEVLG------CWVFGRV-FCNI
WAAVDVLCCTASILSLCIISVDRYIGVKHCLKYP-CIMTERKAVAILAVVWLSSSVISVGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------QPVDESICRITEEPG---YALFSSLFSFYLP-LMVILIMY-------FRVYVVAR
--------------------------------------------------------------------------------
------------------RTSSSLEAGMKRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RNN-SMEVVLR---------------
--------------------------------------------------------------------------------
--------------------------M------------------------------------------RLMKFSRERKA
AKTLAIVVGMFILCWLPFFLFLPI-------ALK--------PSETVFKVIFWLGYFNS--------CINPIIYPCSSKE
--------------FQRAFIRLL---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Oryzias_latipes_ADRA1D_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------FTMDPQVVGV
GIFLSVFILVAIVGNILVILSVVCNKQLQT-VTNFFIVNLAIADLLVSIIVLPFSASLEVLG------CWMFGRV-FCNV
WAAVDVLCCTASILSLCMISIDRYIGVKHCLKYP-SIMTERKAVAILMLVWVSSLVISVGPLLGWKEP------------
--------------------------------------------------------------------------------
-------------------------PPVDESICRITEEPG---YALFSSLFSFYLP-LLVILIMY-------FRVYVVAR
--------------------------------------------------------------------------------
------------------RTTKSLEAGVKRE-------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RDK-SVEVVLRIHCRSVLGDARP--A
S-------------------------------------------------------------------------------
------------SKSSKNHPFRSSLSV------------------------------------------RLMKFSREKKA
AKTLAVVVGMFIVCWLPFFLFLPIG--M----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Apis_mellifera_ADRA1D
----------------------------------------------------------------------------MNES
AVYLLGSEEEGN---------QLNR--------SFY-------------------------------SASYPP-------
-QNRSQEEDLWN------------------------------------------------------------LATDRAGL
AILLFLFSVATVFGNTLVILAVVRERYLHTAT-NYFVTSLAFADCLVGLVVMPFSAIYEVLEN-----RWLFTTD-WCDV
WRSLDVLFSTASILNLCVISLDRYWAITDPFTYP-SKMSRRRAAVLIAIVWICSSAISFPAI--VWWRAV----------
--------------------------------------------------------------------------------
------------------RTEEVPEDK-----CPFTEHLG---YLIFSSTISFYLP-LFVMVFTY-------YKIYR-AA
VIQTKSLKLGT---------------------------------------------------------------------
--------------KQVLMASGELELTLRIHRGGGTNTDAR---------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------HLFRTASSTPEDLQDLEEPLTTIQHNN----CLT-----
----------------------------------------RIPSTRINKQHT----------------------------
-------------RGNNFSLSRKLAK-----------------------------------------------FAKEKKA
AKTLGIVMGVFIICWLPFFVVNLWSGFCSQCIWQ---------EKIVFAAVTWLGWINS--------GMNPVIYACWSRD
--------------FRRAFVRILCACCPGRVRRRYQPAFRCKPSQRFASGRYYSAYSLHHVRSSRESSCEQTYI------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Homo_sapiens_ADRA2A
--------------------------------------------------------------------------------
------------------------------------MFRQEQP-----------LAEGSFAPMGSLQPDAGNASWNGTEA
PGGGARATPYS--------------------------------------------------------------LQVTLTL
VCLAGLLMLLTVFGNVLVIIAVFTSRAL-KAPQNLFLVSLASADILVATLVIPFSLANEVM------GYWYFGKA-WCEI
YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN-LKRTPRRIKAIIITVWVISAVISFPPLIS-IEKKG----------
--------------------------------------------------------------------------------
--------------GGGGPQPAEPR-------CEINDQKW---YVISSCIGSFFAP-CLIMILVY-------VRIYQIAK
RRTRVPPSRRGPDAV--AAPPGGTERRP----------------------------------------------------
NGLGPERS-AGPGGAEAEPLPTQLNGAPGEPAPAGPRD--------------------TDALDLEE------------SS
SSDHAER-------------------------------------------------------------------------
-----------------------------------------------PPGPRRPERGPRGKGKARASQVKPGDSL-----
----------------------------------------PRRGPGATGIG-----------------------------
---------TPAAGPGEERVGAAKASRW------------------------------------------RGRQNREKRF
TFVLAVVIGVFVVCWFPFFFTYTLTAVG----CS--------VPRTLFKFFFWFGYCNS--------SLNPVIYTIFNHD
--------------FRRAFKKILCRGDRKRIV------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Mus_musculus_ADRA2A
--------------------------------------------------------------------------------
------------------------------------MFRQEQP-----------LAEGSFAPMGSLQPDAGNSSWNGTEA
PGGGTRATPYS--------------------------------------------------------------LQVTLTL
VCLAGLLMLFTVFGNVLVIIAVFTSRAL-KAPQNLFLVSLASADILVATLVIPFSLANEVM------GYWYFGKV-WCEI
YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN-LKRTPRRIKAIIVTVWVISAVISFPPLIS-IEKKG----------
--------------------------------------------------------------------------------
--------------AGGGQQPAEPS-------CKINDQKW---YVISSSIGSFFAP-CLIMILVY-------VRIYQIAK
RRTRVPPSRRGPDAC--SAPPGGADRRP----------------------------------------------------
NGLGPERG-AGPTGAEAEPLPTQLNGAPGEPAPAGPRD--------------------GDALDLEE------------SS
SSEHAER-------------------------------------------------------------------------
-----------------------------------------------PPGPRRPDRGPRAKGKTRASQVKPGDSL-----
----------------------------------------PRRGPGAAGPG-----------------------------
---------ASGSGHGEERGGGAKASRW------------------------------------------RGRQNREKRF
TFVLAVVIGVFVVCWFPFFFTYTLIAVG----CP--------VPSQLFNFFFWFGYCNS--------SLNPVIYTIFNHD
--------------FRRAFKKILCRGDRKRIV------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Monodelphis_domestica_ADRA2A
--------------------------------------------------------------------------------
------------------------------------MLHQEHP-----------LAEGSFAPMGSLQPDSGNGSLNGTE-
PGGGSRETPYS--------------------------------------------------------------LQVTLTL
VSLAGLLMLLTVFGNVLVIIAVFTSRAL-KAPQNLFLVSLASADILVATLVIPFSLANEVM------GYWYFGKV-WCEI
YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN-LKRTPRRIKAIIFTVWVISAVISFPPLIS-IEKKG----------
--------------------------------------------------------------------------------
--------------G---DKQVEPL-------CDINDQKW---YIISSSIGSFFAP-CLIMILVY-------VRIYQIAK
RRTRVPPSRR-------SDGCEGAERRP----------------------------------------------------
NGLAD------PGRGEGQPLPAKLNG-TGDPVPAEREV---------------------NGLDLEE------------SS
SSEHPEQTPG----------------------------------------------------------------------
-----------------------------------------------PPGPRKGERGLRGKNKTKMSQVKPGDSL-----
----------------------------------------PRRG------------------------------------
---------------GEEERG-AKASRW------------------------------------------RGRQNREKRF
TFVLAVVIGVFVVCWFPFFFTYTLTAVC----CS--------VPPTLFKFFFWFGYCNS--------SLNPVIYTIFNHD
--------------FRRAFKKILCRVDRKRIV------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Gallus_gallus_ADRA2A
--------------------------------------------------------------------------------
-----------------------------------------------------MEYQRQLEEEEGYPPSGANGTFNDSG-
-AGLGWSMPYP--------------------------------------------------------------LHTTVTL
ISLVGLLMLFTVFGNVLVIIAVFTSRAL-KAPQNLFLVSLASADILVATLVIPFSLANEVM------GYWYFGKV-WCEI
YLALDVLFCTSSIVHLCAISLDRYWSITQAIEYN-LKRTPRRIKCIIFIVWVISAVISFPPLIS-IEKKS----------
--------------------------------------------------------------------------------
--------------GQQVDQWAAG--------CKINDEKW---YIISSSIGSFFTP-CLIMILVY-------VRIYQIAK
RRTRVPLNKR----------PERPEKKQ----------------------------------------------------
NGLADKED---------LPASAQLNGEKAAGAGDGQEG-------------------EVNGIDMEE------------TS
SSEHQEN-------------------------------------------------------------------------
------------------------------------------------NQPKKSERPLRGKTKTKLSQIKPGDTL-----
----------------------------------------PR--------------------------------------
---------------KTEEERNTKGSRW------------------------------------------RGRQNREKRF
TFVLAVVIGVFVICWFPFFFTYTLTAVCK--SCS--------VPPTLFKFFFWFGYCNS--------SLNPVIYTIFNHD
--------------FRRAFKRILCRIERKRIV------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Anolis_carolinensis_ADRA2A
--------------------------------------------------------------------------------
------------------------------------MFQAEVAFVGR---EGGFSGVAHLRSGHPPLPMEGNASLNGSQ-
-GGTR-EGPFS--------------------------------------------------------------LHVTLAL
ISLATLLMLVIIFGNVLVIIAIFTSRAL-KAPQNLFLVSLASADILVATLVIPFSLANEVM------GQWSFGKV-WCEI
YTALDVLFCTSSIVHLCAISLDRYWSITQAIEYN-LKRTPRRIKSIIFLVWVISAIISFPPLIS-IMKQGEPEAPP----
--------------------------------------------------------------------------------
--------------GEPTESKAGGKEP----TCSINKETW---YIISSSIGSFFAP-CLIMVLVY-------VRIYQIAK
RRTRVPPGDR----------QEVAERRQ----------------------------------------------------
NGLSGKED---------VTAASKLNGEKVAVAGGSQDRE------------------EVNGIDLED------------TS
SSEHNES-------------------------------------------------------------------------
------------------------------------------------HEPKKQEKPPRGKGKTKLSQIKPGDVL-----
----------------------------------------PS--------------------------------------
---------------QAEEERNAKASRW------------------------------------------RGRQNREKRF
TFVLAVVIGVFVICWFPFFFTYTLTAVCE--SCF--------VPETLFKFFFWCGYCNS--------SLNPVIYTIFNHD
--------------FRRAFKKILCRLDRKRIG------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Danio_rerio_ADRA2A_a
--------------------------------------------------------------------------------
---------------------------------------------------------------------MICGAN----A
TNGTNATKEYT--------------------------------------------------------------LLVALPL
SVAVGLLILLIIFGNVLVIIAVFTSRAL-RAPQNLFLVSLASADILVATLVMPFSLANELM------GMWTFGGV-WCEI
YLALDVLFCTASITHLCAISLDRYWSITQAIEYN-LKRTPQRIKRIIFIVWIIAAVISCPPLIT--MKKS----------
--------------------------------------------------------------------------------
-------------------EGD---------ICDINKEKW---YIVSSCIGSFFLP-CIIMVLVY-------IRIYQIAK
KRTRAPPGDHRKN---------EVGKKE----------------------------------------------------
NDP--------HEKLNG----------IQNAEPDDKDE--------------------INGVDMEE------------SS
SSDHKVS-------------------------------------------------------------------------
--------------------------------------------------NPCSLKKKSSKGKTKLSQIKPGDGD-----
----------------------------------------KT--------------------------------------
-----------------EACQTTKASRW------------------------------------------KGRQNREKRF
TFVLAVVIGVFVICWFPFFFTYTFTAFCD--CC---------VPETLFKFFFWFGYCNS--------SLNPIIYTIFNND
--------------FRRSFKKILCRRDKRRVV------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Takifugu_rubripes_ADRA2A_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------AMAPDNQ----T
NRTVGEALPYS--------------------------------------------------------------LQMSVPL
TVLVGIMILLTVFGNVLVVIAVFTSRAL-RAPQNLFLVSLASADILVATLVMPFSLANELM------GYWYFGEV-WCEI
YLALDVLFCTASIAHLCAISLDRYWSITQAIEYN-LKRTPRRIKCIIFIVWVMAAVISFPPLIT--MEKE----------
--------------------------------------------------------------------------------
-------------------NGKEEP------ACKINDKKW---YVISSCIGSFFLP-CLIMVLVY-------VRIYQIAK
KRTRAPPGDRKPRPAAKTATVDVADRKE----------------------------------------------------
NG------------LGG---AELKE---NPGGPQEKGQ--------------------ANGVDLEE------------SS
SSDHKVD-------------------------------------------------------------------------
--------------------------------------------------MACSIKKKTPKGKTRLSQIKPGEDQ-----
----------------------------------------AP--------------------------------------
-----------------TRAPSTKASRW------------------------------------------KGRQNREKRF
TFVLAVVIGVFVVCWFPFFFTYMLRTLCE--SCP--------VPDTLFKFFFWFGYCNS--------ALNPIIYTIFNND
--------------FRRSFKKILCRRDTRRYV------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Oryzias_latipes_ADRA2A_a
--------------------------------------------------------------------------------
-----------------------------------------------------INNMDYYHSITNIVVDMNLSDRRRRLT
MRSSSPAEPRSSR------------------------------------------------------------LQVALPL
SVLVGVMISLIVFGNVLVVIAVFTSRAL-RAPQNLFLVSLASADILVATLVMPFSLANELM------GFWYFGKV-WCEI
YLALDVLFCTASIAHLCAISLDRYWSITQAIEYN-LKRTPRRIKSIIVIVWVIAAVISFPPLIT--MEKE----------
--------------------------------------------------------------------------------
-------------------NGSESP------VCKINDEKW---YVISSCIGSFFLP-CIIMVLVY-------VRIYQIAK
KRTRAPPGDRQQKGLSGPG-AAAAGQRE----------------------------------------------------
NGVGEPDDGLCHEKLNGEQDVELKEG-VERGADEAKVE--------------------VNGGDMEE------------SS
SSDHKAD-------------------------------------------------------------------------
--------------------------------------------------HPCSIPKKSAKGKTRLSQVKPGDAD-----
----------------------------------------PQ--------------------------------------
-----------------RRAQSAKASRW------------------------------------------KGRQNREKRF
TFVLAVVIGVFVVCWFPFFFTYMLKTLCS--SCY--------VPTALFNFFFWFGYCNS--------ALNPIIYTIFNHD
--------------FRRAFKKILCR-ERRKY-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Homo_sapiens_ADRA2B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MDHQDPYS--------------------------------------------------------------VQATAAI
AAAITFLILFTIFGNALVILAVLTSRSL-RAPQNLFLVSLAAADILVATLIIPFSLANELL------GYWYFRRT-WCEV
YLALDVLFCTSSIVHLCAISLDRYWAVSRALEYN-SKRTPRRIKCIILTVWLIAAVISLPPLIYK---------------
--------------------------------------------------------------------------------
-----------------GDQGPQPRGR---PQCKLNQEAW---YILASSIGSFFAP-CLIMILVY-------LRIYLIAK
RSNRRGPRAKGGPGQGESKQPRPDHGGA-------------------------------------------------LAS
AKLPALAS-VASAREVNGHSKS-TGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPED------------EA
EEEEEEEEE-----------------------------------------------------------------------
-----------------------------------------------CEPQAVPVSPASA-CSPPLQQPQGSRVL-----
----------------------------------------ATLRGQVLLGR-----------------------------
--------------GVGAIGGQWWRRR--------------------------------------------AQLTREKRF
TFVLAVVIGVFVLCWFPFFFSYSLGAICP-KHCK--------VPHGLFQFFFWIGYCNS--------SLNPVIYTIFNQD
--------------FRRAFRRILCRPWTQ---TAW---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Mus_musculus_ADRA2B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MVHQEPYS--------------------------------------------------------------VQATAAI
ASAITFLILFTIFGNALVILAVLTSRSL-RAPQNLFLVSLAAADILVATLIIPFSLANELL------GYWYFWRA-WCEV
YLALDVLFCTSSIVHLCAISLDRYWAVSRALEYN-SKRTPRRIKCIILTVWLIAAVISLPPLIYK---------------
--------------------------------------------------------------------------------
-----------------GDQRPEPHGL---PQCELNQEAW---YILASSIGSFFAP-CLIMILVY-------LRIYVIAK
RSHCRGLGAKRGSGEGESKKPHPAAGGV-------------------------------------------------PAS
AKVPTLVSPLSSVGEANGHPKP-PREKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEK------------GA
EEDEEEVEE-----------------------------------------------------------------------
-----------------------------------------------CEPQTLPASPASV-FNPPLQQPQTSRVL-----
----------------------------------------ATLRGQVLLSK-----------------------------
--------------NVGVASGQWWRRR--------------------------------------------TQLSREKRF
TFVLAVVIGVFVVCWFPFFFSYSLGAICP-QHCK--------VPHGLFQFFFWIGYCNS--------SLNPVIYTIFNQD
--------------FRRAFRRILCRQWTQ---TGW---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Pelodiscus_sinensis_ADRA2B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
AAVITFLILFTIFGNSLVILAVLTSRAL-TAAQNLFLVSLAAADILVATLIIPFSLANELM------GYWHFQKT-WCEI
YLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYN-AKRTPRRIKCIILIVWMIAAFISLPPLIYK---------------
--------------------------------------------------------------------------------
-----------------GNKGGHEAGR---PQCKLNEEAW---YILSSSIGSFFAP-CIIMILVY-------LRIYLIAK
HRTRHGSTGKKPQAGEKGA------ARK-------------------------------------------------TAG
LSVETSPQ-QPDAREPSGHQGR----VEDEDPP---MTPTCPAHRTSLLSLEEQPPPPVASPCQPP------------VE
TKEPPGSSP-----------------------------------------------------------------------
------------------------------------------------PERSPRCSLKQS-NGHAQSSARGMETL-----
----------------------------------------ATAKGEVLLVR-----------------------------
--------------RVKTLSASPWKRK--------------------------------------------THLNREKRF
TFVLAVVIGVFVLCWFPFFFLYSLGAICP-ELCK--------VPESVFQFFFWIGYCNS--------TLNPIIYTIFNQD
--------------FRKAFRKLLCRQGPR---TAW---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Xenopus_tropicalis_ADRA2B
--------------------------------------------------------------------------------
----------------------------------------------------------------NPVLQKRVSCVGCPVN
TSTMVAPLSYS--------------------------------------------------------------IQATAVI
AAIITFLVLFTIFGNVLVIIAVLTSRSL-KAPQNLFLVSLAAADILVATLIIPFSLANELM------GYWYFGKT-WCEM
YLALDVLFCTSSIVHLCAISLDRYWSVSQAIEYN-SKRTPKRIKCIILIVWTLAALISLPPLIYK---------------
--------------------------------------------------------------------------------
-----------------G-KSKDQNAK---PECKLNEEPW---YILSSSICSFFAP-CLIMILVY-------LRIYLIAK
RRNRKNSTDKK--------------LKK-------------------------------------------------MAP
GLFSRTNKHSLNSSHTQTQCGI----ISS-------------QEKTGLALDDLHCGVPVLSSTREE------------RN
GHSESFGLQ-----------------------------------------------------------------------
------------------------------------------------PQGE---NLKHT-NGCEP---AVMDTV-----
----------------------------------------ATVKGVMLMPK-----------------------------
--------------GAKDSDLSSAKKK--------------------------------------------SYINREKRF
TFVLAVVIGVFVLCWFPFFFTYSLGAICT-ELCY--------IPDSVFQFFFWIGYCNS--------SLNPVIYTIFNQD
--------------FRKAFRRILCSHWSQ---TTW---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Danio_rerio_ADRA2B_a
--------------------------------------------------------------------------------
------------------------------------------------------MDSPCPVAVGLPGHTNGTGGTSSPTC
NQSMIKLAPYS--------------------------------------------------------------PEATAAF
ATAITLMMLITIVGNILVIIAVLTSRSL-RGPQNLFLVSLAAADILVATLIIPFSLANELM------GYWYFRSV-WCEI
YLALDVLFCTSSIVHLCAISLDRYMSISRAVTYG-PKRTPKRIKCAILVVWLISAVISFPPLLSM---------------
--------------------------------------------------------------------------------
-----------------NKNKG-GGESGALPQCQLNDERW---YILYSTIGSFFAP-CLIMILVY-------MRIYQIAK
QRTRCPPGEPRKEAPANATTPQHKIQNGRGDETPGTLQKKARPPTLAVSQVESVQQAANTP----------------IAN
NLLQAPSTTLTPTTPCPSPSPS--NSSEVAPSKSKEGKKEKKKKNNKNKNKKEPDNNNGESMSSDS------------DT
EQ---GGRGLE---------------------------------------------------------------------
------------------------------------------------VPCTPTMTPSG--IHSPATMQKYRDMI-----
----------------------------------------ATAKGAKLVA------------------------------
--------------RKAKQDGTPNSARR------------------------------------------KAMVNREKRF
TFVLAVVIGVFVICWFPFFFSYSLQAVCP-ESCA--------LPEPLFKFFFWIGYCNS--------CLNPVIYTIFNKD
--------------FRRAFKKILCKNTKG---TFF---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Homo_sapiens_ADRA2C
--------------------------------------------------------------------------------
---------------------------------------MASPALAAALAVAAAA-GPNASGAGERGSGGVANAS----G
ASWGPPRGQYS--------------------------------------------------------------AGAVAGL
AAVVGFLIVFTVVGNVLVVIAVLTSRAL-RAPQNLFLVSLASADILVATLVMPFSLANELM------AYWYFGQV-WCGV
YLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYN-LKRTPRRVKATIVAVWLISAVISFPPLVS--LYRQ----------
--------------------------------------------------------------------------------
-----------------PDGAAYPQ-------CGLNDETW---YILSSCIGSFFAP-CLIMGLVY-------ARIYRVAK
LRTRTLSEKRAP------VGPDGAS-------------------------------------------------------
--------------PTTENGLGAAAGAGENGHCAPPP-----------ADVEPDESSAAAERRRRR------------GA
LRRGGRRRAGAEGG------------------------------------------------------------------
--------------------------------------------AGGADGQGAGPGAAESGALTASRSPGPGGRL-----
----------------------------------------SRASSRSVEFF-----------------------------
--------------LSRRRRARSSVCRR------------------------------------------KVAQAREKRF
TFVLAVVMGVFVLCWFPFFFSYSLYGICR-EACQ--------VPGPLFKFFFWIGYCNS--------SLNPVIYTVFNQD
--------------FRRSFKHILFRRRRRGFRQ-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Gallus_gallus_ADRA2C
--------------------------------------------------------------------------------
----------------------------------------------------MDLLLLGNTSLGSPNGSLALLPPSSPSS
AALLQPPSPYS--------------------------------------------------------------PAAVASL
AALVGFIIVFTIVGNVLVVIAVLTSRAL-RAPQNLFLVSLASADILVATLVMPFSLANELM------NYWYFGKV-WCNI
YLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYN-LKRTPRRIKAIIVTVWLISAVISFPPLIS--MYRD----------
--------------------------------------------------------------------------------
-----------------PEGDVFPQ-------CKLNDETW---YILSSCIVSFFAP-CLIMVLVY-------IRIYRVAK
LRTRTLSEKR--------TMPEGSSQTE----------------------------------------------------
NGLSR---------AAGGCTSLRMQLG-ENGHYSVHH---------------WRKASELEDIELEE------------SS
TSESRRRR-SREEH------------------------------------------------------------------
-----------------------------------------------P-RKSSKSQSFSYSYS----SKHSSSRL-----
----------------------------------------SRSSNRSMEFF-----------------------------
--------------SYRRRRKRSSICRK------------------------------------------KVTQAREKRF
TFVLAVVMGVFVVCWFPFFFSYSLYGICR-EACE--------VPETLFKFFFWIGYCNS--------SLNPVIYTIFNQD
--------------FRRSFKHILFKKKKKNFRH-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------
>Xenopus_tropicalis_ADRA2C
--------------------------------------------------------------------------------
----------------------------------------------------MEALENSTTTNS------------TPFP
SSGVRGVWPYS--------------------------------------------------------------MTSVWCL
AAIVGFLIIFTIVGNVFVVIAVLTSRAL-KAPQNLFLVSLASADILVAALVMPFSLANELM------GYWYFGNV-WCDI
YLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYN-LKRTPRRIKGIIVTVWLISAVISFPPLIS--MDRD----------
--------------------------------------------------------------------------------
-----------------TEDDVYPQ-------CKLNDDTW---YILSSCIGSFFAP-CIIMILVY-------IRIYQVAK
LRTRTLSEKK--------PTRDGSSHTE----------------------------------------------------
NGFSK-------------GTTVKMPGDKENGHCPPRP--------------SPPKATDVEDLELEE-----