>Homo_sapiens_ADAMTS1
--------------------------------------------------------------------------------
------------------------------------------------------------------------MQRAVPEG
FGRRKLGSDMGNAERAPGSRSFGPVPT------------------LLLLAAALLAVSDALGRPSEEDEELVVPE------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------LERA----PGHG------------TTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPET
--------------------------DLAHCFYSGTVNGDPSSAAALSLCEG-VRG--------------AFYLLGEAYF
IQPLP-AASERLATAAP---------------GEKPPAPLQFHLLRRNRQGDVG--------------------------
-----------------GTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQ--------WSPQDPALQGVGQPTGTGSIRK
KRFVS--------------------------------------SHRYVETM-LVADQSMAEFHG--SGLKHYLLTLFSVA
AR-------------------------------LYKHPS--IRNSVSLVVVKILVIHDEQ-----KGPEVTSNAALTLRN
FCNWQKQHNP-PSDRDA----------EHYDTAILFTR-----QDLCGSQT---CDTLG-MADVGTVCDPSRSCSVIEDD
GLQAAFTTAHELG-HVFNMPHDDAKQCASLNGVNQDS---HMMASMLSNLDHS-QPWSPCSAYMITSFLDNGHG--ECLM
DKPQNPI----QLPG----DLPGT--SYDANRQCQFTFGED---------------SKHCPD------------------
------------------------------------------------------------------AASTCSTLWCTGTS
G-GVLVCQTKH--FPWADGTSCGEGK----WCINGKCVNKT-DRKHFDT---PFHGSWGM------WGPWGDCSRTCGGG
VQYTMRECDNPV---------------PKNGGKYCEGKRVRYRSCNLED----CPDNN---GKTFREEQCEAHNEFS-KA
SFGSGPAVEWIPKYAGVSPKDRCK-----LICQAKGIGYFFVLQPKVV------DGTPCSP-------------DSTSVC
VQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHD--------------------------IITIP
TGATNIEVKQRNQRGSRNNGSFLAIKAAD--GTYILNGDYTLSTLEQDIMYKGVV-LRYSGSSAALERIR--SFSPLKEP
LTIQVLTV-----GNALRPKIKYTYFVKK---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KKESFNAIPT----------------
-----------FSAWVIEEWGECSKS----CELG-WQRRLVECRDINGQPASECAK------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------EVKPASTRPCADHPCPQ---WQLGEWSSCSKTCGKGYKK-----------RSLKCLSHDGG
VLSHESCDPLKKPKHFIDFCTMAECS------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Mus_musculus_ADAMTS1
--------------------------------------------------------------------------------
------------------------------------------------------------------------MQPKVPLG
SRKQKPCSDMGDVQRAARSRGSLSAHMLLL---------------LLASITMLLCARGAHGRPTEEDEELVLPS------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------LERA----PGHDS----------TTTRLRLDAFGQQLHLKLQPDSGFLAPGFTLQTVGRSPGSEAQHLDP
T------------------------GDLAHCFYSGTVNGDPGSAAALSLCEG-VRG--------------AFYLQGEEFF
IQPAPGVATERLAPAVP---------------EEESSARPQFHILRRRRRGSGG--------------------------
-----------------AKCGVMDDETLPTSDSRPESQNTRNQ---------------WPVRDPTPQDAGKPSGPGSIRK
KRFVS--------------------------------------SPRYVETM-LVADQSMADFHG--SGLKHYLLTLFSVA
AR-------------------------------FYKHPS--IRNSISLVVVKILVIYEEQ-----KGPEVTSNAALTLRN
FCSWQKQHNS-PSDRDP----------EHYDTAILFTR-----QDLCGSHT---CDTLG-MADVGTVCDPSRSCSVIEDD
GLQAAFTTAHELG-HVFNMPHDDAKHCASLNGVSGDS---HLMASMLSSLDHS-QPWSPCSAYMVTSFLDNGHG--ECLM
DKPQNPI----KLPS----DLPGT--LYDANRQCQFTFGEE---------------SKHCPD------------------
------------------------------------------------------------------AASTCTTLWCTGTS
G-GLLVCQTKH--FPWADGTSCGEGK----WCVSGKCVNKT-DMKHFAT---PVHGSWGP------WGPWGDCSRTCGGG
VQYTMRECDNPV---------------PKNGGKYCEGKRVRYRSCNIED----CPDNN---GKTFREEQCEAHNEFS-KA
SFGNEPTVEWTPKYAGVSPKDRCK-----LTCEAKGIGYFFVLQPKVV------DGTPCSP-------------DSTSVC
VQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKMSGIVTSTRPGYHD--------------------------IVTIP
AGATNIEVKHRNQRGSRNNGSFLAIRAAD--GTYILNGNFTLSTLEQDLTYKGTV-LRYSGSSAALERIR--SFSPLKEP
LTIQVLMV-----GHALRPKIKFTYFMKK---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KTESFNAIPT----------------
-----------FSEWVIEEWGECSKT----CGSG-WQRRVVQCRDINGHPASECAK------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------EVKPASTRPCADLPCPH---WQVGDWSPCSKTCGKGYKK-----------RTLKCVSHDGG
VLSNESCDPLKKPKHYIDFCTLTQCS------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Dasypus_novemcinctus_ADAMTS1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MEAARRPRSSQRALS-RL---------------LLAVAAVLLTVPGTGGRPAQEDEELVLPE------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------LQRA----GEHE------------TTRLLLDAFGRRLLLELQPDHGFLAPGFTLQTVGRSPEPETPRPES
S------------------------GDLAHCFYSGTVNGDAHSAAALSLCEG-VRG--------------AFYLQGEEYF
IQPAPAAASVRLAP--AAHGE-------------EPPQQPQFHLLRRRRRGGDG--------------------------
-----------------AKCGVMDDEILPPRGAGPE-DGTGEQ---------------WSQRDRAPQSAEQPTGTGSIRK
KRFVS--------------------------------------SPRYVETM-LVADQSMADFHG--GGLKHYLLTLFSVA
AR-------------------------------LYKHPS--IRNSVSLVVVKILVIYEEQ-----KGPEVTSNAALTLRN
FCNWQKQHNP-LSDRDA----------EHYDTAILFTR-----QDLCGAQT---CDTLG-MADVGTVCDPSRSCSVIEDD
GLQAAFTTAHELG-HVFNMPHDDAKQCASINGMNRDS---HLMASMLSNLDRS-QPWSPCSASMITSFLDNGHG--ECLM
DKPQNPI----QLPS----DLPGT--LYDANRQCQFTFGEE---------------SKHCPD------------------
------------------------------------------------------------------TASTCTILWCTGIS
G-GLQVCQTKH--FPWADGTTCGEGK----WCVGGNCVNKT-DRKHFDI---PVHGSWGP------WGPWGDCSRTCGGG
IQYTMRECDNPV---------------PKNGGKYCEGKRVRYRSCNIED----CPDNN---GKTFREEQCEAHNDFS-KA
SFGTGPAVEWTPKYAGVSPKDRCK-----LICQAKGIGYFFVLQPKVV------DGTPCSP-------------DSTSVC
VQGQCVKAGCDRIIDSKKKFDKCGICGGNGSTCKKISGSVTSAKPGYHD--------------------------VITIP
TGATNIEVKHRNQRGSRNNGSFLAIRAAD--GTYILNGDFTLSTLEQDITYKGSV-LRYSGSSAALERIR--SFSPLQEP
LTIQVLTV-----GNALRPKIKYTYFVKK---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KKESFNAIPT----------------
-----------FSEWVIEEWGECSKS----CGSG-WQRRLVECRDINGQPASECAK------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------EVKPASTRPCAEGPCPH---WQLGDWSPCSKTCGKGYRK-----------RTSKCVSHEGA
VLSQESCDLLKKPKHYIDFCTMAECS------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Gallus_gallus_ADAMTS1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------IRNWK---------------LPFICSQYCGRKMYXQRP-AARQALVLPR------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------RLG-----------SAG------GRERFRLEAFGERLTLELEPDSSFLAPDFTLQYLGG-PPPPSSSSPP
PGD-----------------------DLARCFYSGTVNRDPGSAAALSLCAG-MRG--------------AFSLRGREYL
IQPAPG--------------------------AAAHRLGPHLLRVRG-PRAPAA--------------------------
-----------------SRCAVTEQGEK-RGRGGGARAG--------------------AGALG--------AQTRSKRK
KRFVS--------------------------------------SPRYVETM-LVADQSMAEFHG--SGLKHYLLTLLSVA
AK-------------------------------LYKHPS--IRNSISLVVVKIMVIYEER-----KGPDISSNAALTLRN
FCSWQKQHNP-PSDRHA----------EHYDTAILFTR-----QDLCGAKT---CDTLG-MADVGTVCDLNRSCSIIEDD
GLQAAFTTAHELG-HVFNMPHDDAKQCAGINGISRDF---HMMASMLSNLDRS-QPWSPCSAYMITTFLDNGHG--ECLL
DKPHRPI----QLPS----DLPGT--LYDANRQCQFTFGDE---------------SKHCPD------------------
------------------------------------------------------------------AASTCTTLWCTGTS
G-GLLVCQTKH--FPWADGTSCGEGK----WCMNGKCVNKT-EKKHYDT---PVHGSWGS------WGAWGECSRSCGGG
VQYSFRECDNPV---------------PRNGGKYCEGKRVQYRSCNIED----CPDNN---GKTFREEQCEKHNEFS-KS
TFGSGPAVEWTPKYAGVSPKDRCK-----LVCRAKGTGYFFVLQPKVV------DGTPCSP-------------DSTSVC
VQGQCVKAGCDRMIGSNKKFDKCGICGGNGSTCKKVSGTFVRAKPGYHD--------------------------VVTIP
AGATNIEVKQRNHRGARHDGSFLAIKAAD--GTYVLNGDYTLSTLEQDITYKGSV-LRYSGSSAALERIR--SFSPLKEP
LTIQVLTV-----GDLPQPKIKFTYFVKKPA---QPASEKV---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------PSKKKESFNAIKEI---------------
----------ISSEWVIEEWGECSKS----CGSG-WQRRAVECRDPRGRPATDCAR------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------ELKPSDIRPCADIPCPQ---WQLGDWSACSKTCGKGFKK-----------RLLKCISYDGG
VLPQESCEPSKKPKHLIDFCNVTDCS------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Xenopus_tropicalis_ADAMTS1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------AKMMGYL---------------LPWMAALLCARN-ALGMGTALEEELVAPV------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------RLDP----GTTQGESGN------GKVRYHLNVFGESLTLDLEPDRTFLAPDFSLQYVGS--PAERNGGAE
PLA-----------------------ELAKCFYSGSVNGDSTSSAALSLCSG-LRG--------------AFFYRGEEYL
IQPSNHT--------------LT---------VADPDSPDPLVLHLVRRRSRAK--------------------------
-----------------AKCGVTDSVGQ-PVKSEDAPSQ--------------------RTMPPTEKKATKKRSGSSRRK
KRFVS--------------------------------------SPRYVETM-LVADQSMAEFHG--SSLKHYLLTLMSVA
AK-------------------------------LYKHPS--IRNSISIVVVKILVIYDEQ-----KGPDVSSNAALTLRN
FCSWQKQHNP-PSDRHA----------EHYDTAILFTR-----QDLCGAQT---CDTLG-MADVGTICDPTRSCSIIEDD
GLQAAFTTAHELG-HVFNMPHDEAKQCSGLNRDNQDS---HMMASMLSNLDRY-EPWSPCSAYMITSFLDNGHG--ECLL
DKPHRPI----QLPS----DLPGT--LYDANKQCQFTFGDE---------------SRHCPD------------------
------------------------------------------------------------------AASTCTTLWCTGVS
G-GLLVCQTKH--FPWADGTSCGEGK----WCINGKCMDQT-DKKHYET---PVHGGWGA------WGQWGECSRTCDGG
VQYSVRECDNPV---------------PKNGGKYCEGKRVQYRSCNIQD----CPENN---GKTYREEQCEAHNDLS-KS
PFGSGPAVEWTPKYAGVSPKDRCK-----LMCRAKGTGYFFVLNPKVV------DGTPCSP-------------DSTSMC
IQGQCVKAGCDRVIGSSKKFDKCGVCGGNGSTCKKVSGNFIISRPGYQD--------------------------VVTIP
AGATNIEVKQRNNRGSRHDGSFLAIKAAD--GNYILNGDYTLSTLEQDIIHNGNI-LRYSGSSASLERIR--SFSPLKEP
ITIQVLTV-----GDSHRLKIKYVYFVKKTG---QPEK------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------PNKKKESFNAIRET---------------
----------ILSEWVIEEWGECSKT----CGLG-WQRRTVECKDINGQPSTDCAN------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------ELKPDDIRPCADTPCPQ---WQLGDWSSCSKTCGKGFKK-----------RLLKCVSYDGV
SMPQENCDPLKKPKHLIDFCTLANCS------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Danio_rerio_ADAMTS1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------MSFLRVVLSLAGFALCVNAAQ---------------SAWEESFVLPVRLDTQPG------HTKQS------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------REED----SEKR--------------IYRLDVFGKRMVLALEPDQTFLAPGFVFQMVGKPETG----EFD
SAG------------------------EARCFFSGTVNGDELSSAAINLCKG-LHG--------------GFSVGGEEYF
IQPENS-TGAA--------------------------TDRDTHTIRRRTPGILAEE------------------------
---------------SGSKCGVNEEEERVTEKPHTTHSKPSES------------------K-------------AHHRS
RRFVS--------------------------------------TPRYLEIM-IVADQSMAEFHG--AQLKPYLLTIMAVA
SR-------------------------------LYRHPT--IHNSITLAVVKLLVVHDEE-----HGPHVSTNAALTLRS
FCQWQKQHNQ-PSDRHP----------EHYDTAVLFTR-----KDLCGAHS---CDTLG-MADVGTACDPDRSCSIIEDD
GLQAAFTVAHELG-HVFNMPHDDAKQCASVNGDQWGA---HMMASTLSNLNQL-DPWSPCSALMVTSFLDNGHG--QCLL
DKPQKPE----ELPQ----TLPGS--VYDADRQCRLTFGEE---------------SQHCPD------------------
------------------------------------------------------------------LSSTCAALWCTVTS
ANGLLVCQTKN--FPWADGTPCGSNS----YCMAGQCLSKTEAAKY-ET---PVNGGWGS------WGSWGDCSRTCGGG
VQYSFRDCVNPR---------------PKNGGKYCEGKRIQYRSCNTET----CPDSN---GLTFREEQCLAHNDLSSQV
SLGSGEGVEWVPKYAGVSPKDRCK-----LVCRAKGTGYFFILKPKVA------DGTPCTP-------------DSTSVC
VQGQCVKAGCDRVIGSDKRFDKCGICGGDGSTCKKVSGSMERARPGYQD--------------------------VVTIP
AGATHLDVKQRSFGGRSQDNSYLAVRRQD--GSYLLNGDYKLTTLETDISVKGAL-LRYSGSSVLLERLR--SFAPLPEP
LTIQVLSV-----GESPRPRVKYSYFAPRPN---GSNRPSINAISKAVD-------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------AEWFLGEWGTCSKTCGGGIQTRDVMCLDSKRRPSKNCVDELRPAS-----------
---SRQCALQDCPFWFLGEWGTCSKT----CGGG-IQTRDVMCLDHNRRPSKDCVELHPPSSRQCALQDCPAWFLGEWGT
CSKTC---------------------------------------------------------------------------
----------------------------------------------------------------------------GGGI
QKRDVMCLDHNHRPSEDCVELRPASSRQCALQDCPF---WLPGNWSECSRTCGRGFRK-----------RTLSCITHDGH
ILPNSSCNATDRPRPLLNLCNLTPC-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Takifugu_rubripes_ADAMTS1_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------MLLLHIFL-GIIASLCVGTAH---------------GAWEESMVVPVRLDPATRPEPWRTFSVEE------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------QQKR----AEMR--------------EYRLEVFGKELVLELEPDQTFLAPGFVFHIVGSPESEPTPE-SK
NGA------------------------EPGCFYSGTVNGEEHSAAALNLCHG-LRG--------------GFYFQGVEYF
IQPLNSSDFVG--------------------------TEETVHMIRRRARASLAEE------------------------
---------------GSSKCGVNEDEERVPKNLEKEAGRGAANG---------------DQT-------------AHHRT
RRFVS--------------------------------------TPRYLEIM-IVADQSMAEFHG--AGLKPYLLTIMAVA
SR-------------------------------LYRHPS--IHNSISLAVVKLLVVYEEE-----YGPQVSSNAAMTLRN
FCQWQRQHNP-TSDRHA----------EHYDTAVLFTR-----TDLCGAHS---CDTLG-MADVGTVCDPDRSCSIIEDD
GLQAAFTVAHELG-HVFNMPHDDAQLCSEVNGAHWGS---HMMASTLSNLDQQ-QPWSPCSALMVTTFLDNGHG--QCLL
DKPVRPQ----ALPQ----PLPGT--VYDADHQCRLTFGED---------------SQHCPD------------------
------------------------------------------------------------------LSTTCAALWCTVTT
SNGLLVCQTKN--FPWADGTPCGHDS----YCLAGQCLTKSQAAKH-QI---PVNGGWGT------WGPWGDCSRTCGGG
VQYSFRSCDNPL---------------PRNGGKYCEGKRIQYHSCNTET----CPDTN--AGLTFREEQCLAHNDMSAQV
SLGSGEGVEWVPKYAGISPKDRCK-----LVCRAKGTGYFFVLKSKVA------DGTPCSP-------------DSTTVC
VQGQCVKAGCDRVIGSNRRFDKCGVCGGDGSTCKKVSGSLDRARPGYQD--------------------------VVTIP
AGATHVDVKQRATGNGRHDNSYLAVRRQD--GTYLLNGDYKLMTMETDVALRGAL-LRYSGSSATLERIR--SFSPLPEP
LTIQVLSV-----GEAPRPRVKYSYFAPRPN---NG--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------ASTSNN-GG-------------RRPSINAIREVGGAE-----------
--------------WTLREWGPCSQT----CGGG-VQQREVVCLDAYGHPSRDCPE------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------ELRPLASRSCATQPCPT---WLLGDWSVCSKTCGRGFRK-----------RQLRCIGHDGR
TLTNESCDPKDRPRPLLELCTQGAC-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Tetraodon_nigroviridis_ADAMTS1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------MVLLRVCL-AIIATLCVGAAH---------------GAWEESVVVPVRLDPTTPTEPWRTLSVEE------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------QQKQ----AERR--------------EYRLEAFGRDLVLQLEPDQTFLAPGFVFHMVGSPDPDPTPE-PK
SGT------------------------EPGCFYSGTVNGEEHSAAALNLCHG-LRG--------------GFYLQGAEYF
IQPLNSSLLAG--------------------------TEENVHMIRRRSRATLAEE------------------------
---------------GGSKCGVNEDEKRVPINLEREAG-GAVNG---------------AQT-------------VHHRT
RRFVS--------------------------------------TPRYLEIM-IVADQSMAEFHG--AGLKPYLLTIMAVA
SR-------------------------------LYRHAS--IHNSISLAVVKLLVVYEEE-----HGPQVSSNAAMTLRN
FCQWQRQHNP-ASDRHP----------EHYDTAVLFTR-----TDLCGAHS---CDTLG-MADVGTVCDPDRSCSIIEDD
GLQAAFTVAHELG-HVFNMPHDDAQMCSEVNGAHWGS---HMMASTLSNLDQQ-QPWSPCSALMVTTFLDNGHG--QCLL
DKPVRPQ----ALPQ----PLPGS--VYDADHQCRLTFGED---------------SQHCSD------------------
------------------------------------------------------------------PNTTCAALWCTVTT
PNGLLVCQTKN--FPWADGTPCGHDS----SCLAGQCLTRSQAAKH-QI---PVNGGWGL------WGPWGDCSRTCGGG
VQYSFRSCDNPL---------------PRNGGKYCEGKRIQYRSCNTET----CPDTN---GLTFREEQCLAHNDMSAQV
SLGSGEGVEWVPKYAGISPKDRCK-----LVCRAKGTGYFFVLKSKVA------DGTPCSP-------------DSTTVC
VQGQCVKAGCDRIIGSNRRFDKCGVCGGDGSTCKKVSGSLVRARPGYQD--------------------------VVTIP
AGATHVDVKQRAAGNGRHDNSYLAVRRQD--GTYLLNGDYKLMTMETDIALRGAL-LRYSGSSTTLERIR--SFSPLPEP
LTIQVLSV-----GEAPRPRVKYSYFAPRPN---NG--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------ASTSNN-GG-------------RRQSINAITEVGGAE-----------
--------------WTL---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Gasterosteus_aculeatus_ADAMTS1_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------LDVFGKELVLQLEPDQTFLAPGFVFHIVGSPDTDPTQE-PK
SGA------------------------EPGCFFSGTVNGEEHSAAALNLCHG-LRG--------------GFYFQGAEYF
IQPQNSINFTG--------------------------TEKDVHVIRRRDRAVLAEE------------------------
---------------GSSKCGVNEDEEKVPKNLEKEDQHGAANA---------------DQTDYTSVTNGNRHGKEHHRT
RRFVS--------------------------------------TPRYMEIM-LVADQSMAEFHG--AGLKPYLLTIMAVA
SR-------------------------------LYRHPS--IHNSISLAVVKLLVVYEEE-----RGPQVSSNAAMTLRN
FCQWQRQHNP-PSDRHP----------EHYDTAVLFTR-----TDLCGAHS---CDTLG-MADVGTVCDPERSCSIIEDD
GLQAAFTVAHELG-HVFNMPHDDAQLCSGVNGAHWGS---HMMASTLSDLDQQ-QPWSPCSALMITTFLDNGHG--QCLL
DKPVKPQ----ALPQ----PLPGT--VYDADHQCRLTFGDD---------------SQHCTD------------------
------------------------------------------------------------------LSTVCAALWCTVTT
SNNLLVCQTKN--FPWADGTTCGHDS----YCLAGHCLSKSQAAKH-QT---PVNGGWGV------WGPWGDCSRTCGGG
VQYSFRSCENPL---------------PKNGGKYCEGKRIQYRSCSTDT----CPETN---GLSFREEQCLAHNDMTAQV
SLGSGEGVEWVPKYAGVSPKDRCK-----LVCRAKGTGYFFVLKSKVA------DGTPCSP-------------DSTSVC
VQGQCVKAGCDRVIGSSRRFDKCAVCGGDGSTCKKVSGSLERARPGYQD--------------------------VVTIP
AGATHLDVKQRTPGNGRQDNSYLAVRRQD--GTYLLNGDYKLMTMETDIALRGAM-LRYSGSSATLERIR--SFAPLPEP
ITIQVLSV-----GEAPRPRVKYSYFAPRPS---NA--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------ASVSNNNGG-------------RRHSINAIREVGVAE-----------
--------------WTLREWGLCSQT----CGGG-TQQREVVCLDPQGRLSRDCPE------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------ELRPLASRSCATQSCPY---WLLGEWSACSKNCGRGFRK-----------RQLRCIGHDGR
TLTHESCDPKDRPKPLLELCNQTAC-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Oryzias_latipes_ADAMTS1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------MWLLHVS----IVALCVGAAL---------------CTWEESTVVPVRLEPDQR-EPWRTLSAEE------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------EQKV----GEMR--------------VYQLDVFGKQLILRLEPDQTFLAPGFVFHVVGSPESVPALAGSD
SGS------------------------EPGCFFSGTVNGEAHSAAALNLCRG-LSG--------------GFFFEGNEYF
IQPLDSSELD------------------------------QVHSIRRRSRAAHKEE------------------------
---------------GSSKCGVNEDEERMPKNPGEEASHGAPNA---------------EQT-------------ARQRT
RRFVS--------------------------------------TPRYLEIM-LVADQSMAEFHG--AGLKPYLLTIMAVA
SR-------------------------------LYRHPS--IHNSISLAVVKLLVVYEEE-----KGPQVSSNAAMTLRN
FCQWQRQHNP-TSDRHP----------EHYDTAVLFTR-----TDLCGAKN---CDTLG-MADVGTVCDPERSCSIIEDD
GLQAAFTVAHELG-HVFNMPHDDAQLCSGVNGPHWGS---HMMASTLSNLDQQ-QPWSPCSALMITSFLDNGYG--QCLL
DKPVKPQ----PLPQ----PLPGT--VYDVNHQCRLIFGDD---------------SKHCQE------------------
------------------------------------------------------------------HSSTCAVLWCTVTL
PSGLMVCQTKN--FPWADGTACGTES----YCLAGQCLTKSQAAKHQQT---PVNGGWGL------WGPWGDCSRTCGGG
VQYSFRSCDNPL---------------PKNGGKFCEGKRIQYRSCNTET----CPDTN---GLSFREEQCLAHNDMSAQV
SLGSGEGVEWVPKYAGVSPKDRCK-----LVCRAKGTGYFFVLKPKVA------DGTTCSP-------------DSTSVC
VQGQCVKAGCDRIIGSNRRFDKCGVCGGDGSTCKKVSGSLDRARPGYQD--------------------------IITVP
AGATHLDVKQRAPGNGRNDNSYLAVRRQD--GTYLLNGDYKLMTMETDIAMRGAL-LRYSGSSATLERLR--SFAPLPEP
LTIQVLSV-----GEAPRPRVKYSYFAPRPN---NG--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------ASASNNNGA-------------RRQSINAIRDVGTAD-----------
--------------WTLREWGMCSQT----CGGG-IQQREVVCLDPQGRPSLDCPE------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------ELRPLASRPCASQECPT---WLLGEWSGCSKTCGRGFRK-----------RQLSCIGHNGR
TLTNDSCDSKNQPRPLLELCNQTAC-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Homo_sapiens_ADAMTS2
--------------------------------------------------------------------------------
---------------------------------------------------------------------------MDPPA
GAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVR
ARRAAPVRTPSF--------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------PGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQ-GEKGT-------
---------------------TRVEPLLGSCLYVGDVAGLA-EASSVALSNCDGL-------------AGLIRMEEEEFF
IEPLEKGL------------------------AAQEAEQGRVHVVYRR----PPTS--PPLGGPQALD------------
--------------TGASLDSLDSLSRALGVLEEHANSS-RRRARRHAADDD----------------------------
---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN--
-----------------------------IVNEIYHDES--LGAHINVVLVRIILLSYGK----SMSLIEIGNPSQSLEN
VCR--WAYLQQKPDTG---------HDEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPF
AHDWP-------------ALPQLPGLHYSMNEQCRFDFGLG---------------YMMCTA------------------
----------------------------------------------------------------FRTFDPCKQLWCSHPD
N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KRDGSWGAWS------PFGSCSRTCGTG
VKFRTRQCDNPH---------------PANGGRTCSGLAYDFQLCSRQD----CPD----SLADFREEQCRQWDLYFEHG
DAQHHWLPHEHRDA-----KERCH-----LYCESRETGEVVSMKRMVH------DGTRCSYK------------DAFSLC
VRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHG------------------------YIKMFEIP
AGARHLLIQEVDATSHH-----LAVKNLET-GKFILNE---ENDVDASSKTFIAMGVEWEYRD-EDGRETLQTMGPLHGT
ITVLV-----IPVGD-TRVSLTYKYMIHEDSLNVDDNNVLE---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------EDSVVYEWALKKWSPCSKP----CGGGSQFTKYGCRR-RLDHKMVHRGFCAA---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------LSKPKAIRRACNPQECSQPVWVTGEWEPCSQT--CGRTGMQVRSVRCIQ-PLHDNTTRSVH
AKHCNDARPESRRACSRELCPGRWRAGPWS-QCSVTCGNG------------------------------TQERPVLCRT
ADDSFGI-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------CQEERP-ETARTCRLGPCPRNISDPSKKS---------YVVQWLSRPDPDSPIRKISS------------
-----------------------------KGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNNLTNVEGR-----
--IEPPP------------------GKHNDID------------------------------------------------
------------VFMPTLPVPTVAMEVRPSPST--PLEVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPN-----
---------------------------------LIP--RRPSPYEKTRNQRIQELIDEMRKKEMLGKF------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Mus_musculus_ADAMTS2
--------------------------------------------------------------------------------
---------------------------------------------------------------------------MDPPA
GAARRLLCPALLLLLLPPPP-LLLLPPPPASVRLVAATEPPGGPPGQGAERILAVPVRTDAQGRLVSHVVSLETAGAGVR
ARRAALDQTSGL--------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------PGGAAQDPGGRLFYNLTVFGRDLHLRLRPNARLVAPGATVEWQ-GETGD-------
---------------------TRVEPLLGSCLYVGDVADLP-KASSVALSNCDGL-------------AGLIRMEEEEFF
IEPLEKGQ------------------------TDQEAEQGRVHVVYRR----PPTPKPPPVSEPQALD------------
--------------TGVSQGNLDSLSRALGVLEERINSS-RRRVRRHATDDD----------------------------
---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN--
-----------------------------IVNEIYHDES--LGAHINVVLVRIILLSHAK----SMSLIEIGNPSQSLEN
VCR--WAYLQQKPDTD---------HDEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPF
AHDWP-------------ALPQLPGLHYSMNEQCRFDFGLG---------------YMMCTA------------------
----------------------------------------------------------------FRTFDPCKQLWCSHPD
N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KRDGNWGAWT------PFGSCSRTCGTG
VKFRTRQCDNPH---------------PANGGRTCSGLAYDFQLCNPQD----CPN----SLADFREEQCQQWDLYFEHG
DVQHHWLPHEHRDA-----KERCH-----LYCESKETGEVVSMKRMVH------DGTRCSYK------------DAFSLC
VRGDCRKVGCDGVIGSRKQEDKCGVCGGDNTHCKVVKGTFTRSPRKQD------------------------YIKMFEIP
AGARHLLIQEADTTSHH-----LSVKNLET-GKFILNE---ENHLDPNSRSFIAMGVEWEYRN-EDERETLQTIGPLHGT
ITVLV-----IPEGD-TRISLTYKYMIHEDSLNVDDNNVLE---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------DDAVRHEWALKKWSPCSKP----CGGGSQFTKYGCRR-RLDSKMVHRAFCSA---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------LAKPKAIRRACNPQECSQPVWVTGEWEPCTQS--CGRTGMQVRSVRCIQ-PLHNNTTRSVH
TKHCNDHRPESRRACNRELCPGRWRAGSWS-QCSVTCGNG------------------------------TQERPVLCRT
ADDNFGV-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------CREERP-ETARICRLAPCPRNGSDPSKKS---------YVVQWLSRPDPDSPIQKISS------------
-----------------------------KDQCQGDKSMFCRMEVLSRYCSIPSYNKLCCKSCNPPRNLSNTEDGG----
--VEPPP------------------GKHNDID------------------------------------------------
------------VFMPTLPGPTVATQVQPSPGP--PLEAPLNVSSTNATEDHPETNAVDVPYKIHGVDEEVPSPN-----
---------------------------------LIP--RRPSLYVKTRNQRIQELINAVQRKEKPGKF------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Dasypus_novemcinctus_ADAMTS2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------VPPASLDTLSRALGVLEERVNSS-RRRVRRHTADDD----------------------------
---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN--
-----------------------------IVNEIYHDES--LGAHINVVLVRIILLSYGK----SMSLIEIGNPSQSLEN
VCR--WAYLQQKPDTD---------HDEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELGRYLHSYDCLRDDPF
AHDWP-------------ALPQLPGLHYSMNEQCRFDFGLG---------------YMMCTA------------------
----------------------------------------------------------------FRTFDPCKQLWCSHPD
N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KRDGNWGAWT------PFGSCSRTCGTG
VKFRTRQCDNPH---------------PANGGRTCSGLAYDFQLCNPQD----CPD----ALVDFREEQCRQWDLYFEHG
NGQHHWLPHEHRDA-----KERCH-----LYCESQETGEVVSMKRMVH------DGTRCSYK------------DAFSLC
VRGDCKKVGCDGVVGSSKQEDKCGVCGGDNSHCKVVKGMFTRSPKKQG------------------------YIKMFEIP
AGARHLLIQEADSTRHY-----LAVKNLET-GKFILNE---ENDVDPNSKSFIAMGVEWEYRE-DDERETLQTIGPLRGA
IAVLV-----IPEGD-ARISLTYKYMIHEDSLHVDDNNVLE---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------EYSLGYEWALKKWSPCSKP----CGGGSQFTKYGCRR-KLDHKLVHRGFCKA---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------LAKPKAIRRVCNPQECSQPVWVTGEWEPCSQS--CGRSGMQARSVRCIQ-PLHDNTNRSVH
TKYCNNARPEGRRACNRELCPGRWRAGPWS-QTTLACAKGG-----------------------------VSKREVTCKT
MSRRFGM-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------RRKQVS-QKGREAVIGPTHREADHLKKKG---------YVRRWSSHPDHSYLSHFSFS------------
-----------------------------EGHCQGDKSMFCRMEVLSRYCSIPGYNKLCCKSCNLHN-STSVDDR-----
--TEPPP------------------GKQNDIE------------------------------------------------
------------ELMPTLPVPTLVMEVHPPPAV--PLEVPLNASSTNATQDHPETNAVDVPYKIDGLDNEVQPPN-----
---------------------------------LIP--RRPSLFEKTRNQRIQQLIDEMRKKRCSESS------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Gallus_gallus_ADAMTS2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MEPPAGFACVLLCCALCLPAAAPRRPGHRDPILRNIEEYSLVIPTSTDSEGRFLSHLVSGPPKARFRR
AADDLQHKAA----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------NEQIFYNVTVFGREFHFRLRPNSRLVAPGATVEWQ-EDSDE-------
---------------------THIEPLYGNCLYVGDITDLP-NAS-VAISNCDGL-------------AGMIRTDKDEFF
IEPLEKGT------------------------REEEEEGGRTHVVYRR----AAAKKQLPIEDADTLY------------
--------------KAPNLTNLDGLDSALSLIEDGVRRS-RQRHRRHATDDD----------------------------
---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMNI-
------------------------------VNEIYHDES--LGAHINVVLVRIILLSYGK----SMSLIEIGNPSQSLEN
VCR--WAYLQQKPDTG---------HAEYHDHAIFLTRQD---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELNRYLHSYDCLRDDPF
EHDWP-------------SLPQLPGIHYSMNEQCRFDFGLG---------------YMMCTA------------------
----------------------------------------------------------------FRTFDPCKQLWCSHPE
N--PYFCKTKK--GPPLDGTMCAPGK----HCFKGHCIWLTPDIL-------KQDGHWGAWS------KFGSCSRTCGTG
VKYRTRQCDNPH---------------PANGGRTCVGPSYEFQLCNTQD----CPK----DFEDFREEQCRQWDPYFEYQ
NTKHHWLPYEHVDA-----KERCH-----LYCESKETGDVVYMKRMVH------DGTRCSYK------------DAYSIC
VRGECLKVGCDRVIGSTKQEDKCGVCGGDNSHCKVVKGTFSRVPKKQG------------------------HIKMFEIP
VGARHLLIQESDATSHH-----LAIKNRET-GRFILSE---DNYVP-DSKVFIDMGVEWEYRN-DDNRETVQTMGPLRNG
IVILV-----IPHGG-AKISLTYKYMIHEDSLNVDNNNVLE---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------EDSVSYEWALKKWSQCSRP----CGGGFQFTKYGCRR-KTDHKMVHRSYCEL---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------IQKPKPIRRVCNLQECSQPIWVTGEWEPCSKS--CGKTGYQVRSVRCIQ-PLHDNTNRSVH
TKYCNNDRPEGRRPCNRELCPAQWRIGPWS-QCSVSCGNG------------------------------TQDRPVLCRT
SDNAIGL-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------CKEAKP-ENVKICRLPPCPRNISDPSKKT---------YMIQWLSRPDPDYPIQKISS------------
-----------------------------KDHCQGDKSMFCRMEVLSRYCSIPGYNKLCCKSCNMYNNVTEEGNA-----
--TDSNA------------------NKNNVIE------------------------------------------------
------------EELLTTPSPLTGVPTTQPATTSPPPVSKPPMPPSNATDEHPEINAVDVPYKIDGLDNEVSQHN-----
---------------------------------IIT--QRRIPYERTRNQRIQELIAEKRKKETLRRIN-----------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Xenopus_tropicalis_ADAMTS2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------EYSLVTPVSTDSKGKYVSHSVTKRETHRYRR
DASN----------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------LEKTSAERIYYNVTVFGREFHLKLRVNSKLVAPGATIEWE-EDANV-------
---------------------TVIEPLNTNCLYVGDITDLP-NAS-VAISNCDGL-------------AGIIRTEEEEFF
IEPLEKD--------------------------KEGEDEGRVHIVYRRNHTPPTLGPPKILAQIHRAD------------
--------------TKTTQHSPNLLENIIDNVQEQVNST-RKRTRRHASDDD----------------------------
---------------------------------------------FNIEILLGVDDSVVQFHGKEY--VQKYLLTLLN--
-----------------------------IVNEIYHDES--LGAHINVVLVRIIMLSHSK----SSSLIEVGNPSQSLEN
VCR--WAYLQQKPETG---------HAEYHDHAIFLTRQE---FGPSGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVRMGSIMAPLVQAAFHRFHWSRCSQQELSRYLNSYDCLRDDPF
EHNWP-------------SLPQLPGIHYSMNEQCRFDFGLG---------------YMMCTA------------------
----------------------------------------------------------------FRTFDPCKQLWCSHTD
N--PYFCKTKK--GPPLDGTMCSYGK----HCFKGHCIWLTPDIL-------RQDGNWGQWS------KFGSCSRSCGTG
VRYRTRSCDNPH---------------PANGGRSCSGPSYELQLCNTED----CKT----DFDDFREEQCKQWDPYFEYQ
DSKHNWLPYDHPDE-----KERCH-----LYCQSKETGDVVYMKRLTH------DGTRCSYK------------DSYNIC
VRGECLKVGCDKVIGSKKKEDKCGVCGGDNSHCKVVKGTFTRTPRKQG------------------------NVRIFEIP
VGARHLLIQETGASIHN-----LAIKNQAS-GKFILND---ENVTLPDSKIFVNMGIEWEYQN-DDNRETVQTMGPLHNP
ITILV-----IPRGH-SKISLSYKYMIHEDSFNVDNNNVVE---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------DVVVTYEWTLKKWSHCSKP----CGGGHQFTKYGCRR-KSDHKMVHKNFCDS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------IQKLKPIRRVCNLQECSQPLWISGEWEPCTVT--CGKSGYQFRTVKCIQ-PLNDNKNRSVH
NKYCSDDRPEAKRPCNRQPCPAQWRIGPWS-QCSVTCGNG------------------------------TEERQVHCGS
DINKSAN-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------CSEEKP-ETIRICRLSPCSGNASDPYKKN---------YIVQWLSKLDPDYPLHKISS------------
-----------------------------KESCLEDKSMVCRLGILQRYCSVPGYSRMCCKACN----ASQLYND-----
-------------------------SKMNSSS------------------------------------------------
------------DPALPIPSPPTLYNTTVTFTP----DYKQNVSNPNITDQLN--NRVDVPYKIQELQNEVPQLN-----
---------------------------------AIP--RRRSTFGRTKNQRIQQLIAEKVKQESKSKF------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Danio_rerio_ADAMTS2_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MDVTPGCAFFIFFLHFQRADTLYIANSIDSLQHVLREYGLVRPVSVDADGHFLTHAVSASRLSGQGS
HRRRRRQANQ----------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------QGETDHLRETLFYNVTVYGQEFHLRLRLNSRLVAPGAKVEWLEDDNQT-------
---------------------HSEPLLPSDCLYVGYVTNVQ-DTS-VAISNCDGL-------------AGMIRAGQEEFF
IEPLERGGDMTGE---------------------EEGGPGRHHIVYRS----SDIKKPAVNQPADFHP------------
--------------RGSPLGGLAALELLPQHVKKKIN----SRARRETYEDEI---------------------------
---------------------------------------------FNIEVLLGVDCSVVMFHGREH--IQKYLLTLMN--
-----------------------------IVNEIYQDST--LGAHINVVLVRIMMLCSSK----SMGLIELGNASQSLEN
VCR--WAFLQQKEDKN---------DAEYHDHAIFLTRQE---FGPTGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQANECGDEVPMGSIMAPLVQAAFHRFHWSRCSQQELRRYLNTYDCLRDDPF
DHEWP-------------TLPQLPGLQYSMDEQCRFDFGMG---------------YMMCTA------------------
----------------------------------------------------------------YSTYDPCKQLWCSHPE
N--PFFCKTKK--GPPIDGTKCASGK----NCFKGHCIKLTPDIL-------RLDGHWGQWT------KFGSCSRTCGGG
VRFRTRECNNPV---------------PANGGRTCYGNNYEFQLCNTEE----CAE----ALVDFREEQCKMWDPHFEHE
GNKHHWLPYEHSEP-----DERCQ-----LYCQSKETGDVVSMKRMVH------DGTRCSYK------------DPYSVC
VRGECEKVGCDNVIASELEDDKCGVCGGDNSTCKIVKGNFTRSTRKPG------------------------FLKILEIP
RGARHIQIHEFKGTPHI-----LAVKNQAT-DHLFLND---EGDFP-ESRTVIEKGVAWEYTN-NDDMETVQTTGPLRYG
VLIMV-----QSHSI-SKVTISYKYILPEDPLSSMENTLPQ---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------DDTIYFEWALRKWSHCSKP----CGGGKQYTRFGCRR-KSDGKMVHRTLCAN---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------IPKPRAISRACNQKECSEPIWVTGEWEECSKS--CGKTGSQTRPVRCVR-PELDGSYKAIN
AKYCNDDRPEGRRPCNRQLCPAHWRTGPWS-QCSVSCGNG------------------------------TQERQVMCST
PDNAIGI-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------CMDTKP-QSVRSCLPAPCP------NDRGN--------FLIQWLSRADPEFPAPKISS------------
-----------------------------RSRCKGDKSVFCRMEVLSMYCSNPGYRQMCCKSCS-ETNYTSQFNLTRPWT
YTTATPPKTPIRTTLLFRTSQKPSTTTTPSISRWTDISPTSATTKTLKQTTTITFTTGAFTKHPDSFDYEEESSGSFYED
ETWSSVSESESSEFISSSSKPWSTTPQYTTTPE----NENIEMTLLTTPQPNVTATTSPPAIVSLHLSEDKKENNS----
----------------IDVSYRIVSPNEVALNHFVPR-KRVSFREKTQNKRIQELLAEKRRQDFLLQRLKRKPGD-----
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Tetraodon_nigroviridis_ADAMTS2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------LVRPISVDAEGRFLSHAVSAGRVVGGQP
RRRRRRDVGIGPDEWE----------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------EPKAEHVADREKLYYNVTIFGREFHLRLRHNTRLVAPGAKMEWHDDSDST-------
---------------------RRTEPLHDACLYVGDITDTP-GAT-VAISNCDGL-------------AGMIRMEQEEFF
IEPVERGAGVIEE-------------------KEQEGGGGRTHIVYRS----SAVKKNSPVHSPHALC------------
--------------AGADLGAMMDLESLHRGVEQSINHTRAGRMRRQSLERS----------------------------
---------------------------------------------YNIEVLLGVDDSVVQFHGKEH--VQKYLLTLMN--
-----------------------------IVNEIYHDQS--LGAKINVVLVRIIMLGYGK----SMSLIELGNPSQSLEN
VCR--WAFLQQKQDTG---------DAEYHDHAIFLTRQE---FGPTGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDEVHMGSIMAPLVQAAFHRFHWSRCSMQELGRYLHSYDCLRDDPF
DHNWP-------------SLPQLPGLHYSMNEQCRFDFGVG---------------YTMCTA------------------
----------------------------------------------------------------YRTFDPCKQLWCSHPD
N--PFFCKTKK--GPPIDGTMCGNGK----HCFKGHCIWLTPDII-------KQDGNWGAWS------EFGQCSRTCGGG
VKFRTRNCDNPR---------------PANGGRTCVGATYQFQMCNTNE----CED----IYNDPREEQCRTWEPDFELH
SNKHHWLPYEHPDP-----NKRCN-----LHCQSKETRAVALTDRVVL------DGTRCSYK------------DPHSVC
VRGECEKVGCDGVFGSSKQEDKCGVCGGDNSSCKTFKDTITRTSKKQG------------------------CLKVIEIP
RGARHLLIQELKATSHT-----LAVKNVAS-GLFFVNG---ENEYP-ESHSVIEKGVEWEYEY-DNGKETLQTSGPLRHG
ILIMM-----KLHGD-EDVNLSYKYMMNMDSDTAIQNNMLV---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------EDSS-YEWAPKKWSYCSRP----CSGGKQYLRYGCRR-KVDSKMVHKSFCNKS--------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------NMKPRGDVRDCNQKPCPPPVWVTGEWQNCSKT--CGKTGTQIRTVSCMQ-PSEDNTTRSIH
NKHCNDHRPESRRACNRHPCPTQWRVGPWT-QCSVTCGNG------------------------------TQQRKALCHT
RDNTIGL-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------CLDSKP-DTIRVCRLDPCPKGSSDLNKNGN--------ILIQWLSRPN---PYPKISS------------
-----------------------------RQRCTGDRSSFCRIEALKRHCSLPDFRRMCCQSCGGVTNSSGGFVPIRPR-
--VTSPP------------------TSTSSIN------------------------------------------------
------------YFLPSSFKPEVTTELFPSTIP----STGVPLTTVTTGSTKDPTTRARTPLWNTGVDGDVPQNN-----
---------------------------------QIPK-RRVNFRERTKNKRIQELLEEKR--NFLLRKKRGHA-------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------
>Homo_sapiens_ADAMTS3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSAR
DVSS----------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------NPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPI
NNHQPGS---------ATYRIRRTEPLQTNCAYVGDIVDIP-GTS-VAISNCDGL-------------AGMIKSDNEEYF
IEPLERG-------------------------KQMEEEKGRIHVVYKR----SAVEQAPIDMSKDFHY--RE--------
----------------SDLEGLDDLGTVYGNIHQQLNET-MR-RRRHAGEND----------------------------
---------------------------------------------YNIEVLLGVDDSVVRFHGKEH--VQNYLLTLMN--
-----------------------------IVNEIYHDES--LGVHINVVLVRMIMLGYAK----SISLIERGNPSRSLEN
VCR--WASQQQRSDLN---------HSEHHDHAIFLTRQD---FGPAGMQ---------GYAPVTGMCHPVRSCTLNHED
GFSSAFVVAHETG-------HVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPF
DHDWP-------------KLPELPGINYSMDEQCRFDFGVG---------------YKMCTA------------------
----------------------------------------------------------------FRTFDPCKQLWCSHPD
N--PYFCKTKK--GPPLDGTECAAGK----WCYKGHCMWKNANQQ-------KQDGNWGSWT------KFGSCSRTCGTG
VRFRTRQCNNPM---------------PINGGQDCPGVNFEYQLCNTEE----CQK----HFEDFRAQQCQQRNSHFEYQ
NTKHHWLPYEHPDP-----KKRCH-----LYCQSKETGDVAYMKQLVH------DGTHCSYK------------DPYSIC
VRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLG------------------------YLKMFDIP
PGARHVLIQEDEASPHI-----LAIKNQAT-GHYILN----GKGEEAKSRTFIDLGVEWDYNI-EDDIESLHTDGPLHDP
VIVL-I----IPQENDTRSSLTYKYIIHEDSVPTINSNNVIQ--------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------EELDTFEWALKSWSQCSKP----CGGGFQYTKYGCRR-KSDNKMVHRSFCEA---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------NKKPKPIRRMCNIQECTHPLWVAEEWEHCTK--TCGSSGYQLRTVRCLQ-PLLDGTNRSVH
SKYCMGDRPESRRPCNRVPCPAQWKTGPWS-ECSVTCGEG------------------------------TEVRQVLCRA
GDH-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------