>Bos_taurusRAPGEF2(Chromosome_17:_40483943-40580445)
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-----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLCSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPAREAPLPFILL
GGSEKGFGIFVDSVDSASKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT-----
--SCANLKTFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EESLQTLSLQCEPATNTLPKNPTDKKPVKSETSPVAPRAGLQPKAQPQPQPPQ--PP--HKLNQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRRPAEDTISNTSSQLSSPPTSPQSSPRKGYTLAPSGTVDN
FSDSGHSEISSRSSIVSNSSFDSLPVSLPDERRQ--------RPSVSIVETSLASGRLERRPAVEPDQYSLGSCAPLSES
RGLYAA-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYPGDAAGLWASSSHMDQIMFPDHSAKYSRQSQSRESLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSLDADS
SSMTAVTAEEAKPAAMAAHIAVTP-SAAKGLIARKEGRYREPPPTPPGYVGIPITDFPEAHPHPA-----------RKPP
DYTVALQRSRMLARPAEPPAPG----------SARPAPRPQWHRPGDGDPRAGPCAPPGLT-AEEDEDEQVSAV
>Bos_taurusRAPGEF3(Chromosome_5:_32697065-32718624)
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-----------------------------------------------------------------------------MKV
GWPGEGRWQVGLAVEGDSIL-----GAPPLGGLPDVVPEGTLLNMVLRRMYRSRSCS--------YQLLLEHQRPSCIQG
LRWTPLTSSE----------------------------ESLDFSVSLEQAS-------AERVLRAGKQLHRHLLANCPNL
IRDRKYHLRLH-RQCCSGRELVDGILALG-------LGVHSRSQAVGICQVLLDEGALCH--VKHDWAFQDRDTQFYRFP
---GPEPEP---VGVHEL---EEELVEALALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLS------
---NSVK--RELAAVL---LFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRA
ATIILGEDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQG-----------TGPSRPPTPGRNR-YTVMS
GTPEKILELLLEAMRPDSSAHDP----TETFLSDFLLTHS---------VFMPTAQLCAALL----------------HH
FH-------------AEP----AGGSEQERSSYICNKRQQILRLVSQWVTLYGPTLRTDPVATSFLKK--LSDLVS---R
DTRLSNLLREQWPERRRHHRL-----------ENGCGNVSPQMKARNVPVWLPSQDEPLPSSNCAIRVGD----------
------KVPYDICRP-DHSMLTLQLPVTASVREVMAALAQEDGWT-------KGQVLVKVNSAGDAIGLQPDARGVATSL
GLNE-RLFVVNPQEVHELTPHPDQLGP-TVGSAEGLDLVSTKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDV---
--TTANLERFMRRFNELQYWVATELCLCSVPGLRAQLLRKFIKLAAH-LKEQKNLNSFFAIMF-GLSNSAISRLAHTWER
LPHKVRKLYSALERLLDPSWNHRVYR--LALTKLSPPLIPFMPLLLK-DMTFIHEGNHTL-VENLINFEKMR----MMAR
AARMLHHCRSHSNV-PLSPLRSRVSHLHED------------------------SQAVRVSTCSEQSLSTRSPASTWAYV
QQLKVIDN-QRELSRLSRELEP----------------------------------------------------------
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>Bos_taurus_(Cow)RAPGEF4(Chromosome_2:_23644876-23974945)
----------------------------------------------------------------------------MVAA
HA-AHSSS-SAEWIACLDKKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT
NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAG
LLAPPYGVMETGSNNDTFPSKEQT--------PLIEPHVPLRPANTITKVP-------SEKILRAGKILRNAILSRAPHM
IRDRKYHLKTY-RQCCVGTELVDWMLQQT-------PCVHSRTQAVGMWQVLVEDSVLNH--VDQEHHFQDK-YLFYRFL
---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSHLS------
---TTVK--RELAAVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA
ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQPQQKYTVMS
GTPEKILEHFLETIRLEPALNEAT----DSVLNDFVMMHC---------VFMPNTQLCPALV----------------AH
YH-------------AQP----SQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAMAFLEE--FYVSVS---D
DARMLAALKEQLPELEKIVKQ------------ISEDAKAPQKKHKVLLQQFNTGDERAQ-KRQPIRGSD----------
------EVLFKVYCV-DHTYTTIRVPVAASVKEVLSAVADKLGSG-------EGLIIVKMSSGGEKVVLKPNDVSVFTTL
TING-RLFACPREQFDSLTPLPEQEGP-TVGTMGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHHFK-K---
--TTANLDLFLRRFNEIQFWVVTEICLCSQPSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK
LPSKFKKFYAEFESLMDPSRNHRAYR--LTVAKLDPPLIPFMPLLIK-DMTFTHEGNKTF-IDNLVNFEKMR----MIAN
TARTVRYCRSQPFN-PDAAQAN------------------------------------------------KNHQDVRSYV
RQLNVIDN-QRTLSQMSHRLEPRRP-------------------------------------------------------
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>Bos_taurusRAPGEF5(Chromosome_4:_31017033-31222267)
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-------------------------------WGSGPCQTLS-RRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADL
IKDRANLKGFY-RRSCVGSELVDWLLEHCP-------FVQCRSMAIGVWQLLLDMGILSS---VDQHLYFQDTYVFYQFS
-------SEECSYLYCEFEREEE-WQNGVRLLLQLVPLIPSRAGICELSHQKIEDSEESSDE-----ILARLTSAVQREL
AAVI------------------ALKARKSALAQDEENSDKHVTVTEAEA-AADPQAGMMCKLQERDDIGRIELVQKLARE
-SCQFLQTDKKEQEKSEHQLK---QDDEVTTVEVKEQDQNVLVLKKVQSC------GPAPQAGS-----AESDWRYVVVS
GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALLRI----------------
-------------------YSAKKYQGKEENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKT--IYRNVL---D
DVYEYPILEKELKEFQKILGMH---------RRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTESEE----------
-------IFCHVYIT-EHSYVSVKATVSSTAQEILRVVAEKIQHAED----DLALVAVTFSGDKEKHELQPNNLAISKSL
DASG-RIYVYRKDLADTLNPFAENEES--QQRSIRILGMNTWDLALELMNFDWSLFSSIHEQELIYFTFSRQGSGEH---
---TANLSLLLQRCNEVQLWVATEILLCSPLGKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK
IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD
TVRTLRHCRTNQFGGDISPKEH---------------------------------------------------PELKSYV
HHLYVIDS-QQALFELSHRIEPRV--------------------------------------------------------
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>Bos_taurusRAPGEF6(Chromosome_7:_24107824-24297279)
---------------MGEK-----------------PDGN------------------KQLLLRKIAAQARITPVLQDLN
TIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGG--KRG
CDCLVLEPSEMIVVENSKDNEDNILQREIPARQSRRRFRKINCKGERQTITDDVDINS---------YLSLPADLTKMHI
ADNPHPQVTHVSSSQSGCSIASDSGSSSLSDIY--QATESEVGDVDLTRLPEGPVDSEDEEEE-DEDIDRT-DPLQGRDL
VRECLEKEPADKTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCSVMIFEVVEQAGAVILE---DGQELDSWYVILNGTV
EISHPDGKVDNLFMGNSFGITPTLDKQYMHGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVH------
----EHRELDRSGTRKGHIVIKGTPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLASPLDVGTKLLEWFKIDSLRDK-VT
RIVLLWVNNHFNDFEGDPAMTQFLEEFEKNLEDTKMNGHLRLLNIACAAKAK--------WRQVVLQKASRESPLHFSLS
GGSEKGFGIFVESVEPSSKAADAGLKRGDQVMEVNGQNFENITFVKALEILRNNTHLALTVKTNIFVFKELLSRTEQE--
--------------------K-SGVPHIPKIAE-KKSNRHSIQDVPGDLEQTS-QEKGNKKIKANTVSGGRNKIRKIL-D
KTR-FSILPPKLFSDGGLSQS---------QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFS-------N
PSD-IPDQVIRVFKADQQSCYIIISKDTTAKEVVCQAIHEFGLTG-ASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRI
QLNG-RYYLKNNMETETLCSDEDAQEL-VKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLESKTG----
---NTHLKEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLASVARLRGTWEK
LPSKYDKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKK-DMTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRQVVRMTSANMDPAMMFRQRKKRWRSLG-SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYL
SSLDVETD-EEKFQMMSLQWEPAYGTLTKNLNEKKSMKSSEMSPVPLRSAGQTTKAH-------LHQPHRGSQVLQVPAV
NLHPIRKKGQGKDPATLST-----GLPQKILGTAEEVSGGKKHTEDTVSVASSLHSSPPVSPQGSPRKGYTLIPSAKSDN
LSDSSHSEISSRSSIVSNCSVDSMSTALQDERCS---------SQAVAVPESTGALEKTEHSSGIGDHSQLGPG-WTLSK
PSLINKSLAVSSSVSNEEIS---HEHIIIETADSGRGSWTSCSSSSHDNFQSLPNPKGWEF---------------LNSY
RPTHLDGPIAEVEPTDC---EHYSCPKGCSRTCGQCKGSLETNQMRQSWASSSSLSDTYEPNYGTVKRRVLENTPAESSE
GLDHKEGIDPVYKTVTSSTEKGLIVYCVTSPK--KEDRYREPPPTPPGYMGISLADLKEGP------------HLHLKPP
EYSVAVQRSKMMHN-SLSRLPPAS--LSSSPVACVPSKIVIQPQRHKL--------DVTDGDSEADENEQVSAV
>Bos_taurusRAPGEFL1(Chromosome_19:_41109870-41122210)
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------------------------MKPLEKFLKKQTSQLAGRTVAGGPGGGPGSCGGPGGG-------------------
---------------------------GGPGGGGGPAGGPRPLQRRQSVSRLLLPAFLREPPAEPGLEPPPEEDGGEPTG
VAEELGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTPP-------------PWA---------PLGAP
ERPEHLLNWVLERLAGGATRDSA---ASDTLLDDIVLTHS---------LFLPTEKFLQELHHEFLQAG-----------
---------------------------GMEGPEGLGRKQACLAMLLHFLDTYQGLLQEE-EGAGRIIKDLYLLIMK----
DESLYQDLREDTLRLHQLVETVEL-------KIPEESQPP-SKQVKPLFRHFHRIDSCLQTRVAFRGSDE----------
-------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVASSGEKVLLQPTEDCVFTTL
GINS-HLFACTRDSFEALVPLPEEIQV--SPGDTEIHRGEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE---
---TANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAAI-CKQNQDLLSFYAVVM-GLDNAAVSRLRLTWEK
LPGKFKNLFRKFENLTDPCRNHKSYR--EVISKMKPPVIPFVPLILK-DLTFLHEGSKTL-VDGLVNIEKLH----SVAE
KVRTVRKYRSQPLCLDMEASPH--------------------------------------------------HLQTKAYV
RQFQVIDN-QNLLFELSYKLEANSQ-------------------------------------------------------
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>Gorilla_gorillaRAPGEF2(Chromosome_4:_169688579-169781068)
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-----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL
GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-----
--SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPP-AHKINQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN
FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG
RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES
SSLTSVTTEETKPVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP
DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV
>Gorilla_gorillaRAPGEF3(Chromosome_12:_45650278-45674655)
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-----------------------------------------------------------------------------MKV
GWPGENCWQVGLAVEDSPAL-----GAPRVGALPDVVPEGTLLNMVLRRMHRPRSCS--------YQLLLEHQRPSCIQG
LRWTPLTNSE----------------------------ESLDFSESLEQAS-------TERVLRAGRQLHRHLLATCPNL
IRDRKYHLRLY-RQCCSGRELVDGILALG-------LGVHSRSQVVGICQVLLDEGALCH--VKHDWAFQDRDAQFYRFP
---GPEPEP---VGTHEM---EEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLS------
---NSVK--RELAAVL---LFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRA
ATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQG-----------AGPSRPPTPGRNRRYTVMS
GTPEKILELLLEAMGPDSSAHDP----TETFLSDFLLTHR---------VFMPSAQLCAALL----------------HH
FH-------------VEP----AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQK--LSDLVG---R
DTRLSNLLREQWPERRRCHRL-----------ENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIRVGD----------
------KVPYDICRP-DHSVLTLQLPVTASVREVMAALAQEDGWT-------KGQVLVKVNSAGDAIGLQPDARGVATSL
GLNE-RLFVVNPQEVHELIPHPDQLGP-TVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDV---
--TTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAH-LKEQKNLNSFFAVMF-GLSNSAISRLAHTWER
LPHKVRKLYSALERLLDPSWNHRVYR--LALAKLSPPVIPFMPLLLK-DMTFIHEGNHTL-VENLINFEKMR----MMAR
AARMLHHCRSHNPV-PLSPLRSRVSHLHED------------------------SQVARISTCSEQSLSTRSPASTWAYV
QQLKVIDN-QRELSRLSRELEP----------------------------------------------------------
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>Gorilla_gorilla_RAPGEF4(Chromosome_2b:_60618923-60937904)
----------------------------------------------------------------------------MVAA
HA-AHSSS-SAEWIACLDK-RPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT
NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAG
LLAPPYGVMETGSNNDRIPDKENT--------PLIEPHVPLRPANTITKVP-------SEKILRAGKILRNAILSRAPHM
IRDRKYHLKTY-RQCCVGTELVDWMMQQT-------PCVHSRTQAVGMWQVLLEDGVLNH--VDQEHHFQDK-YLFYRFL
---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLS------
---TTVK--RELAGVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA
ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQPQQKYTVMS
GTPEKILEHFLETIRLEATLNEAT----DSVLNDFIMMHC---------VFMPNTQLCPALV----------------AH
YH-------------AQP----SQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEE--FYVSVS---D
DARMIAALKEQLPELEKIVKQ------------ISEDAKAPQKKHKVLLQQFSTGDERAQ-KRQPIRGSD----------
------EVLFKVYCM-DHTYTTIRVPVATSVKEVISAVADKLGSG-------EGLIIVKMSSGGEKVVLKPNDVSVFTTL
TING-RLFACPREQFDSLTPLPEQEGP-TVGTVATFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-K---
--TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK
LPSKFKKFYAEFESLMDPSRNHRAYR--LTVAKLEPPLIPFMPLLIK-DMTFTHEGNKTF-IDNLVNFEKMR----MIAN
TARTVRYYRSQPFN-PDAAQAN------------------------------------------------KNHQDVRSYV
RQLNVIDN-QRTLSQMSHRLEPRRP-------------------------------------------------------
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>Gorilla_gorillaRAPGEF5(Chromosome_7:_22353421-22551715)
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-------------------------------LLEADCDTLS-RRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADL
IKDRVNLKGFY-RRSCVGSELVDWLLEHCP-------FVQCRSMAIGVWQLLLDMGIMLS---VDQHLYFQDTYVFYQFS
-------SDECSYLYCEFEREEE-WQNGVKLLLQLVPLIPARGGICELSHQKIEDSEESSDE-----ILVRLTSAVQREL
AAVI------------------ALKARKSAIEQDEENNDKHVAVTEAES-VPDSQAGVMCKLQERDEIGRIELVQKLAKE
-NYQFLQTDKKEQEKSEHQ------DDEVTTVQVKEQDQSVLVLKKVQCC------GPAPTAGS-----AESHWRYVVVS
GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALLRMGRHS------------
----------------ICTYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKT--IYRNVL---D
DVYEYPILEKELKEFQKILGMH---------RRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEE----------
-------IFCHVYIT-EHSYVSVKAKVSSIAQEILKVVAEKIQYAEE----DLALVAITFSGDKEKHELQPNDLVISKSL
EASG-RIYVYRKDLADTLNPFAENEES--QQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEH---
---TANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK
IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD
TVRTLRHCRTNQFGSDLSPKEH---------------------------------------------------QELKSYV
NHLYVIDS-QQALFELSHRIEPRV--------------------------------------------------------
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>Gorilla_gorillaRAPGEFL1(Chromosome_5:_43957213-43972993)
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---------------------------------GGPSGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEPPPEE-GGEPAG
VAEEPGSGGPCWLQLEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTSP-------------PWA---------PLGAP
ERPEHLLNRVLERLAGGATRDSA---ASDILLDDIVLTHS---------LFLPTEKFLQELHQYFVRAG-----------
---------------------------GMEGPEGLGRKQACLAMLLHFLDTYQGLLQEE-EGAGHIIKDLYLLIMK----
DESLYQGLREDTLRLHQLVETVEL-------KIPEENQPP-SKQVKPLFRHFRRIDSCLQTRVAFRGSDE----------
-------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTAL
GINS-HLFACTRDSYEALVPLPEEIQV--SPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE---
---TANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAAL-CKQNQDLLSFYAVVM-GLDNAAVSRLRLTWEK
LPGKFKNLFRKFENLTDPCRNHKSYR--EVISKMKPPVIPFVPLILK-DLTFLHEGSKTL-VDGLVNIEKLH----SVAE
KVRTIRKYRSRPLCLDMEASPH--------------------------------------------------HLQTKAYV
RQFQVIDN-QNLLFELSYKLEANSQ-------------------------------------------------------
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>Loxodonta_AfricanaRAPGEF2(SuperContig_scaffold_61_8660295-8758857)
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------LRG
IFYLEKEAFSTQEMAFLVRCYA-NCLQPWSS--------------------------------------KLPADFTKLHL
ADSLHPQVTHVSASHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMKTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFLLL
GGSEKGFGIFVDSVDSGSRATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------T
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTT-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT-----
--SCANLKTFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNAAVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EDSLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQPQPPSQQQPLP--HKISQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKPAEDTVSNASSQLSSPPASPQSSPRKGCTLAPSGTVDN
FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERHQ--------RHSVSIVETSLGVGRLERRAVMEPDQYSLGSYAAVSES
RGLYAT-ATGISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYSGDPPGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSVEAES
SSLAPVPTEEAKPAPVPAHIAAPS-STAKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP
DYTVALQRSRMVARSSEVPGPSPVQQPHGHPASSRPVNKPQWHKPNESDPRLAPYQSQGFS-AEEDEDEQVSAV
>Loxodonta_AfricanaRAPGEF3(SuperContig_scaffold_2:_33402093-33426994)
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------SQV
GWPGESRWHLGLAVEASPAL-----GASPAGGLPDVVPEGTLLNMVLRRMHRPRSCS--------YQLLLEHRSPSCIQG
LRWTPLTDSE----------------------------ESLDFSVSLEQAS-------TERVLRAGKQLHRHLLATCPNL
IRDRKYHLRLY-RQCCSGRELVDGILALG-------LGVHSRSQAVGVCQVLLDEGALSH--VKHDWTFQDRDAQFYRFP
---GLEPEP---VGAHEM---EEELVEAVSLLSQRGPDALLTVALRKPPGQRTDEELDLVIEEVL-IEARGHLF------
---NSVK--RELAAVL---LFEPHCKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGK---EGLGLED--GQLSSCDGGR--
-----PECVDHWVWL-------VLQDVEAKTMRLEEHGKVVLVLERTSQG-----------AGPSCPPTPGRNR-YTVMS
GTPEKILELLLEAMRPDSSAHDP----TETFLSDFLLTHS---------VFMPSTQLCAALL----------------HQ
YP-------------PQPQAEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGPVLRTDPVATSFLQK--LSDLVS---Q
DARLSNLLKEQWPERRRHHRL-----------ENGYGNASPQMKARNMAVWLAGQDEPLPNSNCAIRAGD----------
------KVPYDICRP-DHSVLTLQLPVTASVREVMAALAQEDSWT-------KEQVLVKVNSAGDAIGLQPDARGVATSL
GLNE-RLFVVNPQEVHKLTPHPEQLGP-TVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRTV---
--TTANLERFMRRFNELQYWVATELCLCPVPGLRAQLLRKFIKLAAH-LKEQKNLNSFFAVMF-GLSNSAVSRLAHTWER
LPHKVRKLYSALERLLDPSWNHRVYR--LALTKLSPPVIPFMPLLLK-DMTFIHEGNHTL-VENLINFEKMR----MMAR
AVRMLHHCRGHSNV-PLSPLRSRVSHLHED------------------------SQASRISTCSEQSLSTRSPASTWAYV
QQLKVIDN-QRELSRLSREMEP----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Loxodonta_AfricanaRAPGEF4(SuperContig_scaffold_3:_54266370-54608199)
----------------------------------------------------------------------------MVAA
HA-AHSSS-STEWIACLDK-RPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT
NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAG
LLAPPYGVMETGSNNDRIPDKENT--------PLIEPHVPLRPANTITKVP-------SEKILRAGKILRNVILSRAPHM
IRDRKYHLKTY-RQCCVGTELVDWMMQQT-------QCVHSRTQAVGMWQVLLEDGVLNH--VDQEHHFQDK-YLFYRFL
---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLS------
---TTVK--RELAGVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA
ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQSQQKYTVMS
GTPEKILEHFLETIRLEPALNEAT----DSVLNDFVMMHC---------VFMPNTQLCPALV----------------AH
YH-------------AQP----SQGTEQEKMDYTLNNKKRVIRLVLQWAATYGDLLQEDDVAMAFLEE--FYVSVS---D
DARMIAALKEQLPDLEKIVKQ------------ILEEAKAPQKKHKVLLQQFNTGDERAQ-KRQPIRGSD----------
------EVLFKVYCM-DHTYTTIRVPVAASVKEVISAVADKLGSG-------EGLIIVKMSSGGEKVLLKPNDVSVFTTL
TING-RLFACPREQFDSLTPLPEQEGP-TVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-K---
--TTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK
LPSKFKKFYAEFESLMDPSRNHRAYR--LTVAKLEPPLIPFMPLLIK-DMTFTHEGNKTF-TDNLVNFEKMR----MIAN
TARTVRYCRSQPFN-PDAAQAN------------------------------------------------KNHQDVRSYV
RQLNVIDN-QRTLSQMSHRLEPRRP-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Loxodonta_AfricanaRAPGEF5(SuperContig_scaffold_5:_36306537-36526204)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------TLS-RRISNPYLDHTPSQIYGESSSCAGKALRNIIIVQAADL
IKDRVNLKGFY-RRSCVGSELVDWLLEHCP-------FVQCRSMAVGVWQLLLDMGIMLS---VDRHLHFQDTYVFYQFS
-------SDECSCLYCEFEREEE-WQNGVKLLLHLVPLIPARSGICELSHQKIEDAEETSDE-----ILARLTSAVQREL
AAVI------------------ALKARKSAIEQDEENSDKHIAVPEAEG-VPQSQAGVMCKLQERDDIGRIELVQKLARE
-NCQLLQTDKKELEKSEHQ------DDEVTTVQVKEQDQNVLVLKKVPGG------GPAPTSGS-----TENDWRYVVVS
GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALLRH----------------
-------------------YSAKKYQGKEENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKT--IYRNVL---D
DVYEYPILEKELKEFQKILGMH---------RRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTETEE----------
-------IFCHVYIT-EHSYVSVKAKVSTTAQEVLKIVAEKIQHAEE----DLALVAVTFSG--DKHELQPNDFAISKSL
EASS-RIYVYRKDLADTLNPFAESEES--QQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEH---
---TVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK
IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD
TVRTLRHCRTNQFGGDVSPKEH---------------------------------------------------QELKSYV
NHLYVIDS-QQALFELSHRIEPRA--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Loxodonta_Africana_(Elephant)RAPGEF6(SuperContig_scaffold_1:_30481100-30734647)
---------------MNSP-----------------VDPG------------------ARQALKKKPPER----TPEDLN
TIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQILFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGG--KRG
CDCLVLEPSEMIVVENSKGNEESILQREIPARQSRRRFRKINYKGERQTITDDVEINS---------YLSLPADLTKMHL
TDNPHPQVTHVSSSQSGCSIASDSGSSSLSDIY--QATESEVGDVDLTRLPEGPVDSEDEEEE-DEEIDRT-DPLQGRDL
VRECLEKEPADKTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCSVMIFEVVEQAGAIILE---DGEELDSWYVILNGTV
EISHPDGKIENLFMGNSFGITPTLDKQYMHGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVH------
----EHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDK-VT
RIILLWVNNHFNDFEGDPAMTRFLEEFEKNLEDTRMNGHLRLLNIACAAKAK--------WRQVVLQKVSRESPLHFGLN
GGSEKGFGIFVEGVEPGSKAADAGLKRGDQIMEVNGQNFENITFVKALEILRNNTHLALTVKTNIFVFKELLSRTEQE--
--------------------K-TGVPHIPRIAE-KKSNRHSIQDVPGDIEQTS-QEKGNKKVKANTVSGGRNKIRKIL-D
KTR-FSILPPKLFSDGGLSQS---------QDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFS-------N
PSD-IPDQVIRVFKADQQSCYIIISKDTTAKEVVCHAVHEFGLTG-ASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRI
QLNG-RYYLKNNMETETLCSDEDAQEL-VKESQLSMLQLSTIEMATQLSMRDFDLFRNIEPTEYIVDLFKLDSKTG----
---NTHLKEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRGTWEK
LPNKYEKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKK-DMTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRQVVRMTSANMDPAMMFRQRKKRWRSLG-SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYL
SSLDVETD-EEKFQIMSLQCEPAYGTLTKNLGEKRSAKSSEMSPAPMRSAGQTAKAH-------LHQSHRVSQVLQVPAV
NLHPIRKKGQTKDSVTLST-----SLPQKVSGTTEEISG-KKHTEDTISVASSLHSTPPASPQGSPRKGYTLIPPAKSDN
LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCS---------SQALAVPESTGALGKTEPPSGIGDHSQLGPG-WTLSK
PSLI-KGLAVSSSMSSEEIS---HEHIIIEAADSGRGSWTSCSSSSHDNFQNLPNPKSWDF---------------LNSY
RHTHLDGPIAEVEPTDC---DPYSCPVACSRTCGQCRGSLETNQLRQSWASSSSLSDTYEPNYGTVKRRVSENTPAEPSE
GLDAKDGTDPMYKTVTSSTEKGLIVYCVTSPK--KDDRYREPPPTPPGYMGISLADLKEGP------------HPHLKPP
DYSVAVQRSKMMHN-SLPRLPPAP--LSSSPMACVPSKIVTQPQRHNLQLCHPKLADVTDADSEADEDEQVSAV
>Loxodonta_Africana_(Elephant)_RAPGEFL1(SuperContig_scaffold_31:_22204382-22216549)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------MKPLEKFLKKQTSQLAGRTVTGGPGGGPGSYGGPGGG-------------------
---------------------------GGPGGGGGPAGGTAPLQRRQSVSRLLLPAFLREPPAEPGLEPPPEEEGGEPAG
VTEEPGSGGPCWLQLEEVSGPGPLGGGGPLRSPSSYSSDELSPGEPLTSP-------------PWA---------PLGAP
ERPEHLLIRVLERLTGGATRDSA---ASDILLDDIVLTHS---------LFLPTEKFLQELHQYFVRAG-----------
---------------------------GMEGPEGLGRKQACLAMLLHFLDTYQGLLQEE-EGAGRIIKDLYLLIMK----
DESLYQDLREDTLRLHQLVETVEL-------KIPEESQPP-SKQVKPLFRHFRRIDSCLQTRVAFRGSDE----------
-------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVASSGEKVLLQPTEDCVFTTL
GINS-HLFACTRDSYEALVPLPEEIQV--SPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRE---
---TANLELLLQRCSEVTHWVATEVLLCESPGKRAQLLKKFIKIAAI-CKQNQDLLSFYAVVM-GLDNAAVSRLRLTWEK
LPGKFKNLYRKFENLTDPCRNHKSYR--EVISKMKPPVIPFVPLILK-DLTFLHEGSKTL-VDGLVNIEKLH----SVAE
KVRTIRKYRSRPLCLDMEASPH--------------------------------------------------HLQTKAYV
RQFQVIDN-QNLLFELSYKLEANSQ-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Monodelphis_domesticaRAPGEF4(Chromosome_4:_183163317-183573962)
----------------------------------------------------------------------------MVAG
HA-AHFSS-SAEGIPCRDK-RPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITL---FRQGDIGT
NWYAVLAGSLDVKVSETSSH--QDAVTICTLGIGTAFGESILDNTPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAG
LLAPPYGVMETSANNDRH-FIFQT--------PLIEPHVPLRPAKTITQVP-------SEKILRAGKILRNAILSRAPHM
IRDRKYHLKTY-RQCCVGTELVDWMIQQT-------PCVHSRAQAVGMWQVLLEEGVLNH--VDQEHHFQDK-YLFYRFL
---DDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELIHIKALSHLS------
---TTVK--RELAGVL---IFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRA
ASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAG-----------NRASNQGNSQPQQKYTVMS
GTPEKILEHFLETVRLEQPLNEVT----DSVLNDFIMMHC---------VFMPNSQLCPALV----------------AQ
YP-------------FIP----SQGTEQDKMDYALNNKRRVIRLVLQWAALYGDLLQEDEVAMAFLEE--FYVSVS---D
DSRMIAALKDQLPELEKMVKQ------------ISEDAKAPQKKHKVLLQQFNPVEDRAQ-KRQPVRGSD----------
------EILFKVYCL-DHTYTTIRVPVSASVKEVISAIADKLGSG-------EGMIIVKMSSGGEKVVLKPNDVSVFTTL
TVNG-RLFACPREQFDSLTPLPEQEGP-TTGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFK-K---
--TTANLDLFLRRFNEIQFWVVTEICLCAQLSKRVQLLKKFIKIAAH-CKEYKNLNSFFAIVM-GLSNVAVSRLALTWEK
LPSKFKKIYAEFESLMDPSRNHRAYR--LTVTKLDPPLIPFMPLLIK-DMTFTHEGNKTF-IDNLVNFEKMR----MIAN
TVRTVRYCRSQTFN-PDAALAN------------------------------------------------KNHQDVRGYV
RQLNVIDN-QRTLSQMSHRLEPRR--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Monodelphis_domesticaRAPGEF5(Chromosome_8:_301288444-301369787)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------LPT---FDVP--------YFKYI
-------DEE--------DEEDE-WSN--------------------RSQSSTED--ESSDS-----LLS----------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------DRYVVVS
GTPEKILEHLLNDLHLEEVQ----DKETETLLDDFLLTYT---------VFMTTDDLCQALPPQHWPHGPAHLFSLT---
----------------LRTYSAKKYHGREETCDIPRRKRKVLHLVSQWIGLYKDWLHEDEHSKMFLKT--IYRNVL---D
DVYEYPVLEKELKELQKMLGLH---------RRHTVDEYSPHRKNKALFHQFSLKENWLQHRGTVGETEEI---------
-------VVCHVSLV-NDSDPNMYVSVRDAAMSTGFLPVSRLCSHS---------VSFDFLK--EKHELQPNDLAISKSL
ELSG-RIYVYRKDLSETLSPLVESEES--QQRSLRILGMNTWDLAMELMNFDWSLFNSIHEQELIYFTFSRPGSSEN---
---TVNLSLLLQRCNEVQLWVATEILLCSQLCKRVQLVKKFIKIAAH-CKAQRNLNSFFAIVM-GLNTASVSRLSQTWEK
IPGKFKKLFSELESLTDPSLNHKAYR--DAFKKMKPPKIPFMPLLLK-DVTFIHEGNKTF-LDNLVNFEKL----HMIAD
TVRSLRHCRNSHFGGDVSPKEH---------------------------------------------------QELRSYV
HHLHVIDN-QQVLFELSHRIEPRA--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Monodelphis_domesticaRAPGEF6(Chromosome_1:_305147164-305246757)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------ATESEIGDVDLTGLPEAPVDSEDEEEE-DEDIDRTADPLLGRDL
VRECLEKEPADKTDDDI-EQLLEIMHQLPAFAN-MTMSVRRELCSVMIFEVVDQAGAVILA---DGQELDSWYVILNGTV
EISYPDGKNESLCMGNSFGIIPTLDKQYMNGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVQ------
----EHRELDRSGTRKGHIVIKATPERLIMHLIEEHSVVDPTYIEDFLLTYRTFLESPLEVGNKLLEWFKLDSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTGFLEEFEKNLEDTKMKGHLRLLNIACAAKAK--------WRQILLQKTSRESPLFFSLS
GGSE-GFGIFVEGVEPGSKAAEAGLKRGDQIMEVNGQNFENITLGKALEILKNNTHLSLTIKTNIFVFKELISRTKQE--
--------------------K-NGVPHIPKIAE-KKSNRYSIPDMPGDMEQIFPQEKGNKKIKANTVSGGRNKIRKIL-D
KTR-FSILPPKLFSDGSVSQS---------QDDSVLGTRQCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFS-------N
PTD-IPDQVIRVFKADQQSCYIIISKDTTAKEVVSHAVHEFSLTG-APETYSLCEVSVSPEGVIKQRRLPDQFSKLADRI
QLNG-RYYLKNNMETETLCSDEDAQEL-LRESQITLLQLSTIEVATQLSMRDFELFRNIEPTEYIDDLFKLNSKTG----
---NTHLKEFEDIINQETFWVASEILTESNQLKRMKIIKHFIKIALH-CRECKNFNSMFAVIS-GLNLAPVARLRGTWEK
LPSKYEKHLRDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKK-DITFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRQVVRMTSANMDPAVMFRQRKKRWRSLG-SLSQGSTNSNMLDV-QGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYL
ANLNVETD-EEKFQIMSLQWEPAYSTLNKNLSERRSTKSSEMSPVPLRSVGQITKAH-------LHQPNRMSQVLQVPAV
NLYPIRKKGPTKDHIAFGP-----SASQKIVGMSEEVSG-KKPAEDTLSMASSLHSSPPASPQGSPRKGYAHIPSAKSEN
FSDSSHSEISSRSSIVSNCSVDSMSAALQEDRCL---------PQSLSGVDSVGTAEKKENPPVTTDHIQHVAG-WTLPK
PSLV-KGLAVPSSVSTEEIS---HDHITIEAVDSGRGSWTSCSSSSHDNFQNIQNQKSWDL---------------LNSY
RHTHLDVPIAEVEPTNC---EPYLYAEGYTLTNCQPKDGTEWVQSRQSWASSSSLSDTYETNYGTVKRRVVEDSTVEPDE
TLDSHASTDTTYKTVTSSTEKGLIVYCVTSPK--KDDRYREPPPTPPGYMGISLADIKEGPP----------HHPHLKPP
DYSVAVQRSKMVHS-NLSRLSSAS--LGSEPMACISSKIPSQPQWHILQPSHPKLAGVTDADSEADENEQVSAV
>Monodelphis_domestica_RAPGEFL1(Chromosome_2:_197388286-197399193)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------PTERFLQELYH-FVQSD-----------
---------------------------GIEGAEGLGRKQACLAVLLHFLETYQGLLQEE-ECAGRIIKDLYLLIMK----
DESLYQDLREETLRLHQLVETVEL-------KIPEESQPP-SKQVKPLFRHFRRIDSCLQTRVAFRGSDE----------
-------IFCRVYMP-DHSYVTIRSRLSASVQDILGSVSEKLQYSEESGGREDSLILVAVASSGEKVLLQPSEDCVFTTL
GINS-HLFACTRDCYEALVPLPEEIQV--SPGDTEIHRVEPEDIANHLTAFHWELFRCVHELEFVDYVFHGERGRRE---
---TANLELLLQRCSEVTHWVATEVLLCEPLGKRAQLLKKFIKIAAI-CKQNQDLLSFYAVIM-GLDNAAVSRLRLTWEK
LPGKFKNLFRKFENLTDPCRNHKSYR--EVVSKMKPPVIPFVPLILK-DLTFLHEGSKTL-LDGLVNIEKLH----SVAE
KVRTIRKYRSRPLCLEMEASPH--------------------------------------------------HLQTKAYV
RQFQVIDN-QNLLFELSYKLEANSQ-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Danio_rerioRAPGEF5b(Chromosome_19:_3237686-3265667)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MKT--LYRYVL---E
DVYEFPTLEKDLKEFQKLLR-----------RRHTVDDYSPHQKNKALYQQLSLKENSVSLRASPVESRD----------
-------VMCRVYVS-CDSYLSMRVKPAVVAQELLHIVSQRMDRCED----DMMLLAQTYSG--EKRVLQPHDSIYSESL
VAPG-RLIACRRDLSEILPPLTECPDL--GQKPVRLLGINTWDVAVALTNFDWNLFNSIHEQELIFYTFSRQASSGH---
---TVALEFLLQRCNEVQQWVMSEVLLCPSLSKRVQLLKKFIKIAAH-CKAQRNLNSSFAIIM-GLNTAAVSRLNQTWEK
VPGKFKKLFSELELLTDPSMNHKAYR--DAFKKMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKL----HMIAD
TVRLIRHCQMDQTGNELSAVDS---------------------------------------------------AEVRSSV
HYLHIIDN-QQTLFELSHRLEPRV--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Takifugu_rubripesRAPGEF5b(scaffold_45:_363739-385603)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------CAGRSVRNAFLSHGPYP
AKDKIHLARII-RRSYVGVELVQWLCEQCV-------YVRCRTTAVRVWQVLLELGVLLS---VDQRVIFSDSNTYYQFS
-------FEECDSPSCEFRSNEGEWPEAVRLLLQLAPYVQFRSGGGA--NSPSQSHDSTLTG---IATRAKLVCIVQSEL
AAAL------------------ARKTRKALSEQDSETMELSGVCTLRGGGGGGGGGIGTCNREELTSRLGLETVQRLAKD
GCRLLQNHNHRLSDKNQAD-------EALGRVCLKERGRDVLVLQRVKSSVTSPSDRPSPTSSGGGSREDDCDKRYVVVS
GTPLKILEHLLSDLRLDDQRGAPESRESEMLLDDFLLTYL---------VFMTTHDLCQALLG-----------------
------------------TYSSTRCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKT--LYRCVL---E
DLCEFPTLEKDLKEFQKLLR-----------RRHTVDDCPPNQKGKQMYQQLSLKENCVSLRSPAADTRE----------
-------VICCVYVS-ADSYLSVHTHPSLEAHELLRIVSLKLDRAEE----EMVLAVMSNTG--ERRLLQPSDCVYSESL
TPQG-KLVACRRDVTEILPPLSDSTEL--SRRPVRLLGINTWDVAAALTHLDWTLFKSIHEQELAYYTLSHPPGAGH---
---TAALSVLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIAAH-CKAQRNLNSAFAIIM-GLNTAAVSRLNQTWEK
CPGKFKKLFSELELITDPSLNHKAYR--EAFKKMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKLLNPQHMIAD
AVRMIRHCQSDQPGNEVIGVDS---------------------------------------------------AEVRGSV
QYLHIIDN-QQTLFELSHKLEPRA--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Gasterosteus_aculeatusRASGEF5b(groupX:_8815409-8840688)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------RRSYVGVELVQWLCEQCV-------YVRCRTTGVRVWQVLLELGVLLS---VDQRVMFSDSNSYYQFS
-------FEECDSASCDFRSNEGEWPEAVRLLLQLAPYIQFRSGGGA--NSPHPRSEEDSEGNRDICSEMLQIQQVQNEL
AAAL------------------ARKTRKALSEQDSESTDTSQQEPQTPSEESSPGTGTVCGREELTGRLGLEAVQRLAKD
GCRLLQNHNYRVPDRTQADN------EAVGRVCLKERGRDVLVLRRVTSSVTSPSDRPSPTSSGGGSREEDCDKRYVVVS
GTPLKILEHLLSDLRLDDQRGAPECRESETLLDDFLLTYL---------VFMSTNDLCQALLG-----------------
------------------QYPSDRCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKT--LYRCVL---E
DLYEFPTLEKDLKEFQKLLR-----------RRHTVDDCPPNQKSKQMYQQLSLKENCLQLRSPPSETKE----------
-------VICCVHVS-ADSYLSVHTHHSLEGHELLRIVGQKMDRAEE----DMVLAVASHTG--ERRVLQPSDCVYSESM
TPQG-KLVACRRDLTEILPPLTDSAEL--SRRPVRLLGINTCDVAAALTHLDWSLFKSIHEQELAYYTLSRVPGTGH---
---TAALSVLLQRCNEVQQWVMSEVLMCTSLNKRVQLLKKFIKIAAH-CKAQRNLNSAFAIIM-GLNTAAVSRLNQTWEK
CPGKFKKLFSELELITDPSLNHKAYR--EAFKKMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKL----HMIAE
TVRMIRHCQSDQPGNEVIGVDS---------------------------------------------------AEVRASV
HYLHIIDN-QQTLFELSHKLEPRA--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Oryzias_latipesRAPGEF5b(Chromosome_11:_8720895-8734390)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------TSM
LATL------------------AEAE-EDEDEADSEDEDGTN-----------------------SDTFDVPHLRYIDDD
------------SKEEEKEG------SWVDTDCWN-------------------------SSS----------YRYVVVS
GTPLKILEHLLSDLRLDDQRGAQENRESEMLLDDFLLTYL---------VFMSTHDLCQALLV-----------------
------------------TYGGARCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKT--LYRCVL---E
DLYEFPSLEKDLKEFQKLLR-----------RRHTVDDCPPNQKSKQMHQQLSLKENYLHLRTPQTEHKE----------
-------VMCCVYVS-ADSYLSVHTHPSLEAHELLRIVGMKMDRAEE----DMVLAVVSHTG--ERRVLQPSDCVYSESL
TPNG-KLVACRRDLNEVLPPLADSAEL--NKRPVRLLGINTWDVATALTHLDWTLFKSIHEQELVYYTLSRPPGSGH---
---TAALSLLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIAAH-CKAQRNLNSAFAIIM-GLNTAAVSRLNQTWEK
CPGKFKKLFSELELITDPSLNHKAYR--EAFKRMKPPKIPFMPLLLK-DITFIHEGNKTF-HDNLVNFEKL----HMIAD
TVRNIRHCQSDQAGNEVIGVDS---------------------------------------------------ADVRASV
HCLHIIDN-QQTLFKLSHKLEPRA--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Homo_sapiensRAPGEF2(Chromosome_4:_160025330-160281321)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL
GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-----
--SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPP-AHKINQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN
FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG
RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES
SSLTSVTTEETKPVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP
DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV
>Mus_musculusRAPGEF2(Chromosome_3:_79062516-79144977)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MKPLAAPANHG-VLGQQEKQ--------------------------------------SLPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL
GGSEKGFGIFVDSVDSCSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFS-------T
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT-----
--SCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EESLQTLSLQCEPATSTLPKNPGDKKPVKSETSPVAPRAGPQQKVQPQ-QPLAQPQP-PHKVSQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDN
FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSES
RGLYAA-ATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYSGDAASIWASGGHMDQMMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSAEAES
SSMVPVTTEEAKPVPMPAHIAVTP-STTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPA-----------RKPP
DYNVALQRSRMVARPTEAPAPG---QTPPAAAASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV
>Macaca_mulatta_(Macaque)RAPGEF2(Chromosome_5:_151436894-151529507)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL
GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------T
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-----
--SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLLQPQQQPPP-AHKINQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN
FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGVGRMERRTMMEPDQYSLGSYAPMSEG
RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES
SSITSVTTEETKSVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP
DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV
>Pan_troglodytesRAPGEF2(Chromosome_4:_162372821-162464849)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MKPLAIPANHG-VMGQQEKH--------------------------------------SLPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLMTLTKPSREAPLPFILL
GGSEKGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS-------A
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKT-----
--SCANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSTNATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EESLQTLSLQCEPATNTLPKNPGDKKPVKSETSPVAPRAGSQQKAQSLPQPQQQPPP-AHKINQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDN
FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEG
RGLYAT-ATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAES
SSLTSVTTEETKPVPMPAHIAVAS-STTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPA-----------RKPP
DYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFS-TEEDEDEQVSAV
>Rattus_norvegicuRAPGEF2(Chromosome_2:_170472420-170522450)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------S--------------------------------------QLPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRSMTLTKPSREAPLPFILL
GGSEKGFGIFVDSVDSSSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFS-------T
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTA-TPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT-----
--SCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPNKYEKLFQDLQDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLELEMD-EESLQTLSLQCEPATSTLPKNPADRKPVKSETSPVAPRAGPQQKAQPQ-QPLAPPQP-SHKVSQGLQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDN
FSDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQ--------RHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSES
RGLYAA-ATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHTH
FDYSGDATGIWASGGHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSTEAES
SSMVPVTTEEAKPVPMPAHIAVTP-STTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPA-----------RKPP
DYNVALQRSRMVARPTEAPAPG---QTPPAATASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV
>Taeniopygia_guttataRAPGEF2(Chromosome_4:_30007643-30049672)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------LPADFTKLHL
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEAGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLITLTKPSREAPLPFILL
GGSEKGFGIFVDSVDFGSKATEAGLKRGDQILEVNGQNFENIQLTKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE--
--------------------KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHIPPALPVSGTLSSSNPDLLQSHHRILDFN-------T
TP-DLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTA-TPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQEL-LRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKT-----
--GCTNLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVARLRTTWEK
LPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VEGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTRKKKWRSLG-SLSQGSANAAVLDVAQAGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLDLEMD-EESLQTLSLQCEPATNTLPKNTGDKRSGKSETSPVAPRAGIQQKVQQQ-----------HKVNQALQVPAV
SLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLDRHKKQSEDTVSSASSQLSSPPTSPQSSPRKGYTLAPSSTVDN
FSDSGHSEISSRSSIVSNSSFDSMPVPLHDERRQ--------RHSVSIVETNLGVGRIDRRIMIEPDQYSLGSYAPLSET
RGLYAG-ATVLSSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWET------------LPFGHAH
FDSSGDGAGLWASGGHMDQLMFPDHGTKYGRQSQGREGLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEADT
SSITSVPAEETKPAPVPPHTAAAS-SSTKGLVARKEGRYREPPPTPPGYVGIPIAEFAEGGSHPA-----------RKPP
DYNIALQRSRMVARTCETHGTATPQQQSHGHSTGRPVNKPQWHKPNESDPRLAHYPSQGFS-TEEDDTEQITQI
>Xenopus_tropicalisRAPGEF2(Scaffold_GL172746.1:_939170-1044459)
----------------------------------------------------------------------------QDLE
IVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRG
CECIVLEPSEMIVVDYMDENEE-YFQRQASHRQSRRRFRKINQKGERQTIIDTVESYPVGKPPLPRGYHTLPADFTKLHI
TDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQ-QATESEPGDMDLSGLPETAVDSEDDDDE--EDIERASDPLMSRDI
VRDCLEKDPIDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTVVLN---DGEELDSWSVILNGSV
EVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAK--------RRLITLTKPSREAPLPFNLL
GGSDKGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTNLFVFKELLARMLEE--
--------------------KRNSAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVSKKGKANTVGG-RNKLKKIL-D
KTR-ISILPQKPYNDIGIGQS---------QDDSIVGLRQTKHMPATLPVSGTLSSSNPDLLQSHHRILDFN-------T
TPAEQPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTA-VPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRI
QLSG-RYYLKNNMETETLCSDEDAQDL-LRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLKMKT-----
--GCTNLKNFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVSRLRTTWEK
LPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMASVNMDPALMFRTSGKVLLSLKRSLSQGSTNATVLDVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SDLDLEMD-EENLQTLSVQCEPATNTLPKNPCEKRAGKPDTSPVAPRAAAQHKQQQQQQ---------TKVNQALQVPAV
ALYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQCSPRKGYTMAASGTVDN
FSDSGHSEISSRSSIVSNSSFDCV--HLHDDRRQ--------RHSLSIVETNLGVGRADRRAIIDADQCSLGSYAPVAET
RGLYAG-ATVLSSPSMEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIPHQRSWET------------LPFGHVH
FDNTADGSGFWATGGHMDHGIFPDHSTKYGRYSQGREPLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVALEAET
SSITSMTPEETKPLPVPTHVAVTA-SSAKGLIARKEGRYREPPPTPPGYVGIPIADFADGHPPLS-----------RKPP
DYNVALQRSRMMARRSESEGSAATSPPSHNQTSGRTANKPQWHKPNEADPRLALYQAQGVTEKDDADDEQVSAV
>Danio_rerioRAPGEF2(Chromosome_14:_50716244-50966935)
------------------------------------------------------MASYVDNSFRQAVMVNPSDRTQQDLE
IVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRG
CECIVLEPSEMIVVDYMDENEE-YFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPVARGYHTLPADFSRLHL
ADGIHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATESEPGDMDLSGLPETAVDSEEDDDE--EDIERASDPLMSRDI
VRDCLEKDPMDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTHPDSRNEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPSLRDK-VT
RVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAK--------LRVVTLTKPSREAPLAFTLL
GGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVPLSKANEILKNNTHLSITVKTNLLVFKELLARPDQDQE
QEQ------------EEEPDRKNGAPHIPKIGDIKKASRYSIPDLAVDVEQVMDLEKASKKAKANSAGG-RNKLKKIF-D
KTL-TSILPPKPYNDVGVGQS---------QDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFN-------N
QP-DMSDQVLRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTA-AAEAYSLCEVSVTPEGVIKQRRLPEQLSKLADRI
QLSG-RYYLKSNMETETLCSDEDAQEL-LRESHISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKLKTRLT----
--GPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKIALH-CRECKNFNSMFAIIS-GLNLAPVSRLRGTWEK
LPSKYEKLFSDLQDLFDPSRNMAKYRNLLNSQNLQPPIIPLFPVIKK-DLTFLHEGNDSK-VDGLVNFEKLR----MIAK
EIRHVGRMAAVNMDPALMFRTRKKKWRSLG-SLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYL
SNLTLETN-EESLQTLSMQCEPSINTLPKSSGDR--KRPDTSPVVSRAATHQRQQLQ------------KANQALQVPAV
ALYPSRKKVPVKDLPPFGTSSPQSLKKILSLSEEAG-DRHRKQAEDSVSNNSSQLSSPPTSPHSSPKKGYGRAG----DY
LSDSGHSEISSRSSLVSTSSLDMG----QDERRQ--------RYGGTAGEGHGSGHRLERRATADPDQYSLGSYSSMQDC
RGLYAG-ATVLSSPSSEELTQDQGDRVSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWEA------------LAEGAG-
---------------------------LWGS--RGSWASACSSS-----SSVACWGEDSEGDTGTIKRRGGRDVTTDPET
SSITSTGSEESRQHSRRPSPITAG--NTKASITRKDGRYRDPPPTPPGYTALTITDVTEGTP-----------HSGRKPP
DYTTALQRSRLVTHSLDSQQPPAAGKPDPRGREEDEAVEVEEEGECLSPKLRAQRRRGPHTAVPPRP-------
>Takifugu_rubripesRAPGEF2(scaffold_70:_21546-63207)
---------------------------------------------------------------------------SQDLE
IVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRG
CECIVLEPSEMIVVDYMDENEE-YFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPIARGYHTLPADFSRLHL
ADGLHPQVTHVSSSHSGCSITSDSGSSSLSDIY--QATENEPGDMDLSGLPETAVDSEEDDDE--EDIERSSDPLMSRDI
VRDCLEKDPMDRTDDDI-EQLLEFMHQLPAFAN-MTMSVRRELCAVMVFAVVERAGTIVLN---DGEELDSWSVILNGSV
EVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVK------
----EHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPSLRDK-V