>Branchiostoma_floridae_(Amphioxus)FZD1XP_002605403
------------------------------------------MKMRVLVGFGWVGLLVLC-------CVLQGGTLVVRAQ
QFS----------------------------------------------SSSSLGHHGRCEAITIPLCTDIQ--------
--YNETIMPNLLNHQKQEDAGLEVHQ--FFPLVKVQCSPDLKFFLCAMYAPVCT-VLEEAIPP--CRSLCNSARTGCEAL
MNKFGFQWPESLECS----------------------------------KFPVQGTPGKICVGE-------NRTEQIP--
-------TAVPTANNGNSS-------------------------------------------------------------
----AVTENPIRKDYGFYCPRELKVS-------------------PALGYSFLG---------AKDCGAPCDS-------
MYFRDDEVEFAQVWIGIWSVLCACSCLFTVLTYLIDPGRFRYPERPIIFLSACYLMVSVAYIVGYALKEKVSCMEEH---
----------------------------------HRN-FRRILHGTKKEGCTILFMMLYFFSMASSLWWVILTLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTIAILAMGKVDGDVLSGVCFVGISDIDALRGFVLAPLFLYLVIGTLFLLAGFV
SLFRIRTIIKQDG-----TKTDKLEKLMIRIGVFSVLYTVPATIVIACYFYEQAFRREWERSWEI-----DNCKD-----
-YFIPCPPGP-----------HARPS-----ANPDFTVFMIKYLMALIVGITSGIWIWTGKTVQAWKRFYGQICFRKQ--
--DET----------------------------------------------VV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Caenorhabditis_elegans_(Nematode)FZD1(Chromosome_I:_9965578-9969403)
---------------------------------------------MHRHILILFLFGCLSADQRLSSTSISS--MNGFST
TRK--------------------------------------------------------CEHITIPMCKNLD--------
--YNQTVFPNLLGHTTQSEAGPAIAQ--FNPLIKVKCSEDIRLFLCTVYAPVCT-VLEKPIQP--CRELCLSAKNGCESL
MKKFGFQWPDQLDCN----------------------------KFPVTD---LCVGKNSSESSNSKK-------------
-----SSNDVTFGVSTIANE------------------------------------------------------------
----------VVLSPKKCPHHMHTTSGSHF------------------SLPLLSGR-------LPECSLTCEADNQV--P
MMFDGRVRRILRIWTAAWSVACFVCSLFTLVTFLVDLSRFAYPVRPILYLAFCYLAISTVYMIGVVGEDGFACGTYGST-
-------------------------------------PTTLVTQGGENVGCSALAVVHYFFFMSSCAWWLVLCLAWFLAA
NLKWGAESIAALSPYFHAMCWGVPAVLSVTVLVTNSVDGDVFTGICSVGNLNPSALVYFFFTPIVVSLALGAVLLVCGIW
SMIRIRSYIKLQHA-DVERNISKLEKLMLRIGAFAIMYSLPTAMNAAIMWYQAVNMPAWLEGWLHH-----RCVR-----
-LQDRELFGF--------TYPVDDCPMDPKVAAPEIIVFLLKYVSQLVVGITCAIWVVSSKTLSSYHKAYLALSSRSP--
--------------------TVPAHVDQ-----------------------VNMRD------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gallus_gallus_(Chicken)FZD1(Chromosome_2:_22082221-22084532)
----MAERRGPAGG----------------GSGEVGGGRRAGGDRCPRRPP---ALPLLLLLWAAALPAGGQPAAQPAAL
-----------------------------------------------SERGISIPDHGYCQPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQALPP--CRSLCERARQGCEAL
MNKFGFQWPDTLRCE----------------------------------KFPVHGAG-ELCVGQ-------NASERGTPT
------PALRPESWTSNPQ-RG--------------------------GG------------------------------
----AGGSGPGEARGRFSCPRALKVP-------------------SYLNYRFLG---------EKDCGAPCEPGRLY-GL
MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTAVAVAYIAGFLLEERVVCNERF---
----------------------------------AEDGSRTVAQGTKREGCTILFMMLYFFGMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWERSWVT-----QSCKS-----
-YAIPCP----NNH------SSHHPP-----MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQ--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gallus_gallus_(Chicken)FZD2(Chromosome_Un_random:_42059629-42061134)
--------------------------------------------------------------------------------
-----------------------------------------------------VPDHGFCYPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSLELKFFLCSMYAPVCT-VLEQAIPP--CRSICERARQGCEAL
MNKFGFQWPERLRCE----------------------------------NFPRHGAE-QICVGQ-------NHSEDGG--
----SSAALLTSAAPPAAHGTPG---------------------------------------------------------
------APRYATPDRPFHCPRALKVP-------------------GYLNYKFLG---------EKDCAAPCEPSRPD-GH
MFFNEDEIRFARVWILVWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLEERVVCNERF---
----------------------------------QEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNGIDPLRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHGG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFRQHWERSWIS-----QHCKS-----
-LAIPCPLHF-------------TPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGK-------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gallus_gallus_(Chicken)FZD3(Chromosome_3:_108617989-108664669)
--------------------------------------------------------MAVSWMFCCFWLLDVLVGCTRGHS
LFS--------------------------------------------------------CEPIILRMCQDLP--------
--YNTTFMPNLLNHYDQQTAALAMEP--FHPMVNLECSRDFRPFLCALYAPVCMEYGRVTLP---CRRLCQRAYSECSKL
MEMFGVSWPEDMECT----------------------------------RFPDCDEPYPRLVD-----------------
------LSLGGEPTEEAPMA------------------------------------------------------------
----------VQRDYGFWCPRELKIDPDL-------------------GYSFLRVR---------DCSPPCP-------N
MYFRREELSFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPA-
-----------------------------------QYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAA
VPKWGSEAIEKKALLFHASAWGIPGTLTIVLLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII
SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQE-----RCRE-----
-YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALVVGIPSVFWVGSKKTCFEWASFFHGRRKKE---
VVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMLDD-
-------------QRSKAG---SVHSKVSSYHGSLHRSRDGR----------------YTPCSYRGIEERLPHG------
-------------SMSRL-TDHSRHSSSHRLNEQSRHSSIRDLSSNPLTHIT-HGTSMNRVIEEDGTSA-----------
-------
>Gallus_gallus_(Chicken)FZD4(Chromosome_1:_193007130-193011390)
------------------------------------------------MERRGGGGRMLA---LLLAGLLGG--ARGFGD
E-E-----------------------------------------------------ERRCDAIRIAMCQNLG--------
--YNVTKMPNLVGHELQADAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV
LKEFGFAWPDSLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------
-----------VPLHSKT--------------------------------------------------------------
-----------SLQPGEECHSMGSNSD---------------------QYIWVKRN--------LDCVLKCGYD----AG
LYS-RSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF----
---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV
ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWAVFRYSADD---------------
---------------------------------SNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQK--CSNRLV----
--------------------------------------------------NSGKVKR-EKRAD------GWVKPGKGNET
VV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gallus_gallus_(Chicken)FZD5(Chromosome_7:_13194523-13195281)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------LYFFGMASSIWWVFLSLTWFLAA
GMKWGNEAIASYAQYFHLAAWLIPSAKSITVLALSSVDGDPVAGVCYVGNQSLENLRGFVLAPLVVYLFTGSLFLLAGFV
SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTVLYTVPATIVIACYIYEQHNREAWEQAQNCS--------------
-----CPG--------------DPHR-----PKPDYAVFMLKYFMCLVVGITSGVWIWSGKTLESWRRFTARCCR-----
------PKKPAGA---------------------------AAYGEAS---PALV-GRTVLPSM-----ASYHKQVPLSHV
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gallus_gallus_(Chicken)FZD6(Chromosome_2:_134798595-134834093)
----------------------------------------------------------MGVLA-FFVPYSFLLTVVRGHS
LFT--------------------------------------------------------CEPITISRCSRMP--------
--YNMTFFPNIMGHYDQDTAALQMEP--FLTLMNLHCSPDVHTFLCKAFVPACLEQVHVIHP---CRNLCEKVYSDCKQL
IDTFGITWPEELECS----------------------------------RLVNCDETAPATAP-----------------
------VTTNAHGTQKTPGQ------------------------------------------------------------
----------TRRDYGFWCPRHLHTSNGQ-------------------GYKFLGID---------QCAPPCP-------N
MYFKNYELDVAKSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLMYFIGFLLGNRTACNKADDK-
-----------------------------------LEIGETVVLGSQNKACTVLFMVLYFF-MAGTIWWVILTITWFLAA
GRKWSCEAIAQKAMWFHAVAWGIPGFLTIMLLAMNKVEGDNISGVCFVGLYDVDASLYFVLLPLCLCVFFGLSLLLAGII
SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVALLGCYVYELVNRKIWETTWVFD-----HCDQ-----
-YHIPCP--------------YQAKA----LARPEIFLFLMKYLLTLIVGISPVFWVGSKKTCSEWANFFNRNRKRDP--
-ISESRRVLQESCEFFLRHNSKVKHKKK--------------HYKSSSHRLKVISKSMGTSTGGT-TNHGTSAVAITNHD
Y----------LSQETVAEIKTSPETSEKEMEADGTSAQKAEE--------------GENSGNQMLSVSKLTVDQVEKRN
KADS--TCDMSSLSESLKRIGEGRVSPRNDLIESPPLQSSSSQIADVSQ----SGSVSLLVYSAADGRKEMDSGNSSNH-
-------
>Gallus_gallus_(Chicken)FZD7(Chromosome_7:_12741968-12745019)
--------------------------------------MRPAAGGAGAGLRW-LGLAALL------AALLG-TPCAAAHQ
D-----------------------------------------------DKAISVPDHGFCQPISIPLCTDIA--------
--YNQTILPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQAIPP--CRSLCERARQGCEAL
MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDAPPGP
G---GAGGRGATAQPTAGY------------------------LPDLLTPPQ----------------------------
--PA--------AGFSFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPGRPN-GL
MYFKEAEVRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYAAGFLLEERVVCLERF---
----------------------------------SEDGYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDVLSGVCYVGIYSVDSLRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFRSTWEKTWLL-----QTCKT-----
-YAVPCPS--------------HFAP-----MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSTGSK--
--GET----------------------------------------------AV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Ciona_intestinalis_(Ascidian)FZD3(Scaffold_HT000177.1:_126064-132339)
----------------------------------------------------------MDIKLGIIILCCVISEVSTSNV
HPQ--------------------------------------------------------CRPVTLPMCLRNDNERNKGIK
WIYNETTFPNFNNDASESEVEISLSL--LHPLLSTSCSRYLELFLCSVFSPACMGG-GVVPP---CRSLCEVVFDDCAEV
VEAFGIIWPQRLHCDNFPPQNGGKMVDTGSDTWGKMVVSRSSWLVWGEALLGDGEVCIPLSGDDVIT-------------
-----PALSQNNQEIDNVTK------------------------------------------------------------
----------YPGEYGLRCPAQLTAPPNEP------------------GYTFLGMQ---------GCGAPCP-------N
MYMGDDELMLVRYIICVLASLCALVTSFVLFTFAIDTNRFRYPERPIVFYAAAYFVISVIFLVGFALGSDVACKHEIMDE
NNI--------------------------------VIQGAVVVEGPRDRACTIVFMILYFFTVNGTIWWLILTVTWLLAA
GFKWGSEAIEKHHLYYHGLAWGIPAVQTMVVVTTGKIEGDNIAGVCFVGLYDSDGLRFLLLLPMSFYLLVGMFVLLTGFI
CLNRVRKSLH-----DDETNKKKLAKFMLRIGVFSILYILPQLALIAIYAIEDSNRKSWESAWFVR-----NCGR-----
-YGVPCPNL-----------PHPVAQLAQGNPLPGVFIFCMKYIMTLIVALPPLFWVASKKTMASWKEAVTKQRCMDDGN
PLSVTQTQLLNDSNNGPHARDAVRKQQS----------------KHSDVIFGGLGGFQGSSASIAAAEAMTSSRARARQE
LWEDMTSTDSTLSSRSESTLAKVLEYESHKNKGRRVVGRRRHNQGHPLPLTHNPDEGENNREVDDVINKPVPIKMERNNR
IDDVISSQSRSLSDVTRPQSSVTSQPGRPDVVKKQLSISRSDATRSVPDIIKTTELSPPLLRNKPEIPRKPKLSLAKPNT
SGRVLEV
>Ciona_savignyi_(Ascidian)FZD1(reftig_83:_31444-53279)
----------------------------------------------MKAFGRFKEYSTFA------FMLLML--------
-----------------------------------------------GESESQNVHNGKCELITLSICKGIR--------
--YNETIFPNVLGHQDQAEAGLQINQ--FYPLVKVGCSKTLQSFLCSVYTPMCS-IYQQAFPP--CRHMCEEAR-ACEGI
MKQFRFSWPRDLECS----------------------------------RFPIKTED-SLCFGT-------DISPSE---
-----------EIPAFDTG-------------------------------------------------------------
--------RLCLSQAGFTCPAHMLVPST-----------------NDLNYEFMD---------AEGCGVPCDAKK----L
MYWTESEKQFANLWIGCWSFICVISTLFTVLTYLIDMPRFMYPERPIIFLSGCYLIVAIAYIAGFFLRDTVSCRQFHTSI
CPVD----------------------------TPLSSCPKVVTQGAREAGCTVLFMMVYFFSMASSIWWVVLTITWFLAA
GLKWGNEAIEAKSPYFHGAAWSIPAIQTIVVLISSKIEGDLLSGICFVGVHNSKHLLWFLLVPLSIYLFVGTCFLVAGFV
AMFNIRNVVKHSGGT---GKVEKLERLMVRIGVFSVLYTVPATVMIACYFYEQMNRDSWQKGWFA-----QNCRK-----
-MSVPCPCEY-----------AKHKG-----NKPDFIVFIIKYFVMLIVGITSGFWIWSSKTVESWSNFKEQLCCFRS--
--SSQGGAKYQRGA-----------------------------------NNTVQQSGTLPLSGDVMRPLYPISKIDP---
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Xenopus_tropicalis_(Frog)FZD2(Scaffold_GL173432.1:_297317-300337)
-------------------------------------------FSASAMQGVTRSSNLIV------CHLFALC--LLSFA
QLH--------------------------------------------GEKGISVPEHGFCQPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSSELRFFLCSMYAPVCT-VLEQAIPP--CRSICERARHGCEAL
MNKFGFQWPERLRCE----------------------------------NFPRHGAE-QICVGQ-------NHSEDG---
-----GPTLLTTSPP--HHGTPG---------------------------------------------------------
------PPIYATLDHPFHCPRVLKVP-------------------SYLNYRFLG---------EKDCAAPCEPSKND-GF
MFFSQDEIRFARVWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLGDKVVCNENF---
----------------------------------SEDGYKTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVS-----QNCKS-----
-LAIPCPLQY-------------TPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNNKH--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Xenopus_tropicalis_(Frog)FZD4(Scaffold_GL172855.1:_675510-682426)
---------------------------------------------------MGVRALALC----LPLLGCLVGHIAGFGD
E-E-----------------------------------------------------ERRCDPIRISMCQNLG--------
--YNVTKMPNLVGHELQADAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV
LKEFGFAWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDDE------
-----------VPVHSKT--------------------------------------------------------------
-----------PVLPGEDCNSFGPNSD---------------------QYTWVKRS--------MNCVLKCGYD----SG
LYS-RLSKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFCYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF----
---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNIDALTGFVVAPLFTYLVIGTLFIAAGLV
ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWNVFRYTADD---------------
---------------------------------SNMAVEMLNIFMSLLVGITSGMWIWSAKTLHTWQK--CTNRLV----
--------------------------------------------------NSGKVKR-KKRVD------GWVKPGKGNET
VV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Xenopus_tropicalis_(Frog)FZD6(Scaffold_GL172639.1:_1438799-1461513)
----------------------------------------------------------MAARLGKVLLVTLLLPLVQSHS
LFT--------------------------------------------------------CEPITVPRCTGMN--------
--YNMTFFPNLLEHYDQDIAALRMEP--FLPLLNLHCSPEVHTFLCRAFVPECTEPKHITMP---CRSLCERVYSDCKNL
IETFGITWPAELECD----------------------------------RMRDCNNSQSKGGG-----------------
------GPDDPHDALRHPEQ------------------------------------------------------------
----------VHRDFKFWCPQHLKTSQGS-------------------GFKFLGVD---------RCAPPCP-------N
MYFKKVDMDFAKYFIGIISIICLCVTLFTVLTFLIDVQRFRYPERPIIFYSVCYSMVSLMYVIGFLMGNSIVCNEREEN-
-----------------------------------FASGDTVVLGSQHKACTIIFMLLYFCTMAGTIWWVMLTITWFLAA
GRKWSCEAIEQKSLWFHGVAWGIPGILTIILLAMNKVEGDNISGVCFVGLYDQEVSIYFVLLPLCLCVFIGLSLLLAGII
SLNNVRQVIQ-----HDERNQQKLKKFMIRIGVFSGTYLVPLVILLGCYVYEQVYRSSWEMTWVSD-----NCQD-----
-YHIPCP--------------FQLKN----PARPDLGLFITKYIMTLIVGISAIFWVGSKKTCSEWVNFFNRSRKQDP--
-ISESRRVLQESCEFFLKHNAKVKHKKKK-------------HSKSGSHKLKVISKSMGTSTSGK-INHGMTAVTNTSHD
F----------LGQEASGDVRSTLDFSRTEDPEGASCIHKSRDD-I----------TGEVTTQTLLDGTEAPVEHTDCNN
K------------PGSKR--GNGLPGSIHTILHESLHEVAENRVN--------VESASLDPDQTEDLSKVPGHTSPHDND
-------
>Xenopus_tropicalis_(Frog)FZD7(Scaffold_GL172844.1:_1732448-1736539)
----------------------------------------CRAPRIITCCRPGPGMFATVS-----LLFCLLLQPSPSAQ
QY--------------------------------------------HGEKGISVPDHGFCQPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLEQAIPP--CRSLCERARQGCEAL
MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDNS---
-------PSGPTARPTPY-------------------------LPDSITFHP----------------------------
--HP---------NRDFTCPRQLKVP-------------------PYLGYRFLG---------EKDCGAPCEPGKAN-GL
MYFKEEEVRFARLWVGIWAILCGISTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYTAGFLLEERGVCVERF---
----------------------------------SEDSYRTVAQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDILSGVCYVGINSVDSLRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVMYTVPATIVLACYFYEQAFRDTWEKTWLV-----QTCKG-----
-FAVPCPNY-------------NFAP-----MSPDFTVFMIKYLMTMIVGITSSFWIWSGKTLQSWRRFYHRLSNGGK--
--GET----------------------------------------------AV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Takifugu_rubripes(Fugu)FZD2(scaffold_15:_1304591-1306404)
-----------------------------------------LEPKRGEKKQSCLQLGKTW------FVAFLLP--LLVTA
QYH--------------------------------------------GDNG-IVPDHGFCQQISIPLCTDIA--------
--YNQTIMPNLVGHYNQEDAGLEVHQ--FYPLVKVQCSPELKFFLCSMYAPVCT-VLEKAIPP--CRSICERAKQGCEAL
MNKFGFQWPEPLRCE----------------------------------NFPVQGDE-QICVGQ-------NDSTAA---
------------TVPPILP-GPGTS-------------------------------------------------------
-----DLPFPG--NGPFRCPPALKVP-------------------PHLNYKFLD---------EKDCAAPCEPSRRG-GS
MFFTDKEIHFSRVWILVWSVLCCASTLFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSIAYIAGYFLGDAVVCNEGF---
----------------------------------TPENYKTLVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACFFYEQAFRAHWERSWFS-----HNCRA-----
-FDI-CPTQT-------------GPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWHKFYTRLTYGKH--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Takifugu_rubripes(Fugu)FZD3(scaffold_28:_334328-347495)
----------------------------------------GCTKGCPSVCFSLLLIPISMLFFLGTPALCIHLETTESHS
EFS--------------------------------------------------------CEPIRLRMCQDLP--------
--YNTTFMPNLLHHYDQQTAALAMEP--FHPMVNLECSPDLRMFLCALYTPVCVVYGQVSMP---CRSLCQRAKDECHKL
MEIFGVSWPDDMEC-----------------------------------RFPDCDEPYPRPED-----------------
------LLTGSDPTNQSSLT------------------------------------------------------------
----------VQRDYGFWCPRELKVDTDL-------------------GYTFMGKK---------DCSAPCP-------S
MFFSRQELTFIRYFIGVTSLICLSATLFTFLTFLIDVTRFRYPERPIIFYAACYVMVSLVFFLGFLLEDRVACNAASPA-
-----------------------------------HFRAATITQGSHNKVCTLFFMVLYFFAMAGSVWWVILTITWFLAA
VPKWGSEAIEKKALLFHAVAWGLPGALTVALLALNKIEGDGISGVCFIGLYDIDALRWFVLAPLGLNVTVGVSLLFVGIV
ALNKVRMEIP-----LEKENQTKLVKFMIRMGVFSALYVVPLLVVIGCYLYEHTYRSIWETTWMEE-----NCRH-----
-YHIPCP--------------YKVKQ----ISHPAAVLFLMKYLMMLVVGIPSVFWVGSKKTCFEWANFLQGRRRKDS--
GVNESRQVLQEQPDFAQ---SLLREPNT-----------------------PVIRKSRGTSTQGTSTHASSTNLAALDGL
DDPVQTHQRHAASTRNKAS---SVHSK-ASYHGSLRRTREDRYSS------------KSDTVVYRGAGECSFHG------
-------------SLSRLNHPLSTHSSLHQLDGHSRHNSQQDVTEVPPALIR-HGTTA----------------------
-------
>Takifugu_rubripes(Fugu)FZD4(scaffold_172:_247438-252485)
---------------------------------------------MERRRWGESSLLLLLS-----GLLAALCAVKAFGE
ELE-----------------------------------------------------EMTCDPIRISMCQGLG--------
--YNVTKMPNLVGNVLQSDAELQLTT--FTPLIQYGCSSQLKFFLCSVYVPMCTVKIPIPIGP--CSSMCLSVKKKCFPV
LQEFGFIWPEELNCS----------------------------------LFPPQNDHNHMCMEGP-----GDED------
-----------LPYPPLW--------------------------------------------------------------
-----------NPHHQQECHALGSGPD---------------------QYIWLKQT--------ESCTLQCGYD----SG
LYR-RGTKVFTDAWMAVWAVLCFLSTTLTVLTFVLDSQRFSYPERPIIFLSMCCNLYSVAYLVRWTLGREHVSCDL----
---------------------------------EATAVPVLVQEGLKSTGCAIVFLLLYFFGMASSLWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADDLTGLCYVGNQQQEALIGFVVAPLATYLLLGTLFICAGLV
ALFRIRSNLQKDG-----AKTDKLERLMVKIGVFSVLYTVPASTVIGCYIYQLAHWGEFNTIPQD---------------
---------------------------------SYVASEMLRIFMSLLVGITSGMWIWSAKTLHTWQR--CSTRLV----
--------------------------------------------------RDSRASRSGQRAPC----TGWIKPGKGNET
VV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Takifugu_rubripes(Fugu)FZD5(scaffold_31:_1191230-1194595)
----------------------------EKKPTDDYIQYELYVKMIHCVAST-----------TAVLLLLV--PGLTFGA
SKDLV------------------------------------------------------CEPITVPMCKDIG--------
--YNLTYMPNQFNHDTQEEVGLEVHQ--FWPLVRIRCSPDLLFFLCSMYTPICLPDYRKPLPP--CRSVCERAKQGCSPL
MSQYGFEWPERMSCE----------------------------------KLPQLG-D-EVLCMD------QNNTE-----
----STTLAST--FPKPTPK--------------------------VQTRTLSP--------------------------
--------HQCDRECRCRAPLVPIKRE------------------SLTSYHHTHAG------PVPNCAQPCHQP------
-FFSADERAFTSLWIGLWSLLCFISTLTTVATFLIDMERFQYPERPIIFLAGCYLFVSLGYIIRLVAGHEQVACGSSSS-
---------------------------------VHEDQLYLLYDTTGPALCTLVFLLVYFFGMASSIWWVVLSFTWFLAA
GLKWGSEAIAGYAQYFHLAAWLIPSLKTIIILAMSSVDADPVAGICYVGNQSLESLRGFVLAPLVVYLFTGSFFLLAGFI
SLFRIRSIIKQ-----GGTKTDKLERLMIRIGLFTVLYTVPATVVVACLVYEQHYRPGWEETLACS--------------
-----CLT-E-----------QQLLG-----MGPDYAIFMLKYFMCLVVGITSGVWIWSGKTLESWRRFVAHCCP-----
--CWLQT-ATAPP---------------------------SMYSEAS---TALT-GHTGTGLT-----AGFYHKSVSSHI
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Takifugu_rubripes(Fugu)FZD6(scaffold_58:_8671-12922)
--------------------------------------------------------MLMPGPL-WTCLALMWLGSSSAHS
LFT--------------------------------------------------------CEPIKVHRCLGMS--------
--YNMTFFPNMMDHFDQDIAATHMKP--FMPLVNLRCSPDVHRFLCQAFFPACIEN-TVYRP---CREECNTVMSECKAN
IEVFGISWPPELQCD----------------------------------NFFRLDPCFLIGHE-----------------
------TSTET--TPVTSS-------------------------------------------------------------
----------TKRDLGFWCPLQLKTKPGL-------------------GSSFLGTQ---------DCAPPCS-------N
MYFKPHDIEFAKSFIGVCSIICLGATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVSLMYFIGFLLGNNAACTKATHP-
-----------------------------------ASV-DTVVLGSQSKGCTLLFMLLYFFSIAGLVWWVILTITWFLAA
GPKWSCEAIEKKAVWFHSAAWGIPGSLTVMLLALNKVEGDNISGVCFVGLYNLDALRYFVLAPLGVGVIVGLFLILAGIV
SLNNVRQVIQ-----HDERNQEKLKKFMIRIGVFSCLYLVPLVTLLACYTYEQSHRSAWERTWIAD-----RCQE-----
-YSIPCP--------------FEAAE----SDRPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNRTRKKDP--
-ISESRRVLQESCEFFLKHNSRVQHKKK--------------HYSPSSHKLKVISKSMGTSTGAMPSNASATPTL-TNHG
A----------STLSNRDAHPQCSLSEASVRSSRRGVRDREREV--------------GERQSKGGSSSKI---------
--------------------------------------------------------------------------------
-------
>Gorilla_gorilla_(Gorilla)FZD1(Chromosome_7:_88490025-88493836)
------------------------------------------GRRRPPVDPRRLARQLLLLLWLLETPLLLGVRAQAAGQ
GPGQGPGPGQQPPPPP---------------------QQQQSGQQYNGERGISIPDHGYCQPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQALPP--CRSLCERARQGCEAL
MNKFGFQWPDTLKCE----------------------------------KFPVHGAG-ELCVGQ-------NTSDKGTPT
------PSLLPEFWTSNPQHGG----------------------GGHRGG------------------------------
---FPGGAGASER-GKFSCPRALKVP-------------------SYLNYHFLG---------EKDCGAPCEPTKVY-GL
MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKF---
----------------------------------AEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVA-----QSCKS-----
-YAIPCPHLQAGGG------APPHPP-----MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQ--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gorilla_gorilla_(Gorilla)FZD3(Chromosome_8:_28477094-28557203)
--------------------------------------------------------MAMTWIVFSFWPLTVFMGHIGGHS
LFS--------------------------------------------------------CEPITLRMCQDLP--------
--YNTTFMPNLLNHYDQQTAALAMEP--FHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLP---CRRLCQRAYSECSKL
MEMFGVPWPEDMECS----------------------------------RFPDCDEPYPRLVD-----------------
------LNLAGEPTEGAPVA------------------------------------------------------------
----------VQRDYGFWCPRELKIDPDL-------------------GYSFLHVR---------DCSPPCP-------N
MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPA-
-----------------------------------QYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAA
VPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII
SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQE-----RCRE-----
-YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKE---
IVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMVDD-
-------------QRSKAG---SIHSKVSSYHGSLHRSRDGR----------------YTPCSYRGMEERLPHG------
-------------SMSRL-TDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHIT-HGTSMNRVIEEDGTSA-----------
-------
>Gorilla_gorilla_(Gorilla)FZD4(Chromosome_11:_84242635-84257192)
-----------------------------------------KGGGPRSTESPGLISFRIP--LWNFISYRLKATIGGFGD
E-E-----------------------------------------------------ERRCDPIRISMCQNLG--------
--YNVTKMPNLVGHELQTDAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV
LKEFGFAWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------
-----------VPLPHKT--------------------------------------------------------------
-----------PIQPGEECHSVGINSD---------------------QYIWVKRS--------LNCVLKCGYD----AG
LYS-RSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF----
---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV
ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADD---------------
---------------------------------SNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQK--CSNRLV----
--------------------------------------------------NSGKVKR-EKRGN------GWVKPGKGSET
VV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gorilla_gorilla_(Gorilla)FZD5(Chromosome_2b:_96411333-96418144)
------------------------------------------MARPDPSAPP-----------SLLLLLLAQLVGRAAAA
SKAPV------------------------------------------------------CQEITVPMCRGIG--------
--YNLTHMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPP--CRSVCERAKAGCSPL
MRQYGFAWPERMSCD----------------------------------RLPVLGRDAEVLCMD------YNRSE-----
----ATTAPPR-PFPAKPTLPGP--------------------PGAPASGGECP--------------------------
--------AGGPFVCKCREPFVPILKE------------------SHPLYNKVRTG------QVPNCAVPCYQP------
-SFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVAC------
----------------------------------SREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAA
GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFV
SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCA--------------
-----CPGHD-----------AGQPR-----AKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPR--
--RGHKSGGAMAA---------------------------GDYPEAS---AALT-GRTGPPGP----SATYHKQVSLSHV
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Gorilla_gorilla_(Gorilla)FZD6(Chromosome_8:_102551091-102584379)
----------------------------------------------------------MEMFT-FLLTCIFLP-LVRGHS
LFT--------------------------------------------------------CEPITVPRCMKMA--------
--YNMTFFPNLMGHYDQSIAAVEMEH--FLPLANLECSPNIETFLCKAFVPTCTEQIHVVPP---CRKLCEKVYSDCKKL
IDTFGIRWPEELECD----------------------------------RLQYCDETVPVTFD-----------------
------PHTEFLGPQKKTEQ------------------------------------------------------------
----------VQRDIGFWCPRHLKTSGGQ-------------------GYKFLGID---------QCAPPCP-------N
MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEK-
-----------------------------------LELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAA
GRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGII
SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSD-----HCRQ-----
-YHIPCP--------------YQAKA----KARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDP--
-ISESRRVLQESCEFFLKHNSKVKHKKK--------------HYKPSSHKLKVISKSMGTSTGAT-ANHGTSAVAITSHD
Y----------LGQETLTEIQTSPETSMREVKADGASTPRLRKQ------------DCGEPASPAASISRLSGEQVDRKG
Q--------AGCVSESAR--SEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT-
-------
>Gorilla_gorilla_(Gorilla)FZD7(Chromosome_2b:_90515948-90519803)
----------------------------------------MRDPGAAAPLSS-LGLCALV------LALLGALSAGAGAQ
PY--------------------------------------------HGEKGISVPDHGFCQPISIPLCTDIA--------
--YNQTILPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLDQAIPP--CRSLCERARQGCEAL
MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDGS---
----GGPGGGPTAYPTAPY------------------------LPDLPFTAL----------------------------
--PPGASDGRGRPGFPFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPGRAN-GL
MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERF---
----------------------------------SDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLL-----QTCKS-----
-YAVPCPPG-------------HFPP-----MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSK--
--GET----------------------------------------------AV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Apis_mellifera_(Honey_bee)FZD1_XP_623523
-----------------------------------------------------------------MIPRYAIYVFSVAVF
SVN-------------------------------------------ALHTKDPLAHHGRCEPITINLCMNIP--------
--YNETIMPNLMNHQKQEDAGQEVHQ--FAPLVKMKCSPDLRFFLCTVYAPVCT-IIDRAIPP--CRSLCESARAGCERL
MNSFGFAWPDNLDCS----------------------------------KLPENGGP-ELCVGH-------NETTPP---
-----EPSPPVYTPPRMPVAEFQPS------------------WTGGPKTYG----------------------------
-----SGFMLGARDFGFVCPMQFKVP-------------------HELGYSLKVGDK-----VELNCGAPCDG-------
MFFTERERRFSRIWVGTWASVCAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYLMVALAYVIGWAAGNSIACREPFPPP
L-------------------------------DMRIQMASTITQGTKHELCTVLFMVLYFFGMASSIWWVILTLTWFLAA
GLKWGHEAIEANSQYFHLAAWAAPAIKTVTILAMGKVEGDILSGVCYVGLWNVEALRGFVLAPLCVYLILGTAFLLAGFV
SLFRIRTVMKHDG-----TKTDKLEKLMIRIGIFSVLYIVPALIVIACLFYEQAYFDQWMLTWNM-----EMCSRPGPQS
LYSMPCPVGER----------TRDVG-----RRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQFFN-HIQGRR--
--AEA----------------------------------------------YV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD1(Chromosome_7:_90893783-90898123)
MAEEEAPKKSRAAGGG---ASWELCAGALSARLAEEGSGDAGGRRRPPVDPRRLARQLLLLLWLLEAPLLLGVRAQAAGQ
GPGQGPGPGQQPPPPP---------------------QQQQSGQQYNGERGISVPDHGYCQPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSAELKFFLCSMYAPVCT-VLEQALPP--CRSLCERARQGCEAL
MNKFGFQWPDTLKCE----------------------------------KFPVHGAG-ELCVGQ-------NTSDKGTPT
------PSLLPEFWTSNPQHGG----------------------GGHRGG------------------------------
---FPGGAGASER-GKFSCPRALKVP-------------------SYLNYHFLG---------EKDCGAPCEPTKVY-GL
MYFGPEELRFSRTWIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKF---
----------------------------------AEDGARTVAQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVA-----QSCKS-----
-YAIPCPHLQAGGG------APPHPP-----MSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQ--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD2(Chromosome_17:_42634925-42636907)
-------------------------------------------------MRPRSALPRLL------LPLLLLP--AAGPA
QFH--------------------------------------------GEKGISIPDHGFCQPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLEQAIPP--CRSICERARQGCEAL
MNKFGFQWPERLRCE----------------------------------HFPRHGAE-QICVGQ-------NHSEDG---
-----APALLTTAPPPGLQPGAGGT------------------PGGPGGGGA----------------------------
------PPRYATLEHPFHCPRVLKVP-------------------SYLSYKFLG---------ERDCAAPCEPARPD-GS
MFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERF---
----------------------------------SEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVS-----QHCKS-----
-LAIPCPAHY-------------TPR-----MSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRH--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD3(Chromosome_8:_28351773-28431775)
--------------------------------------------------------MAMTWIVFSLWPLTVFMGHIGGHS
LFS--------------------------------------------------------CEPITLRMCQDLP--------
--YNTTFMPNLLNHYDQQTAALAMEP--FHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLP---CRRLCQRAYSECSKL
MEMFGVPWPEDMECS----------------------------------RFPDCDEPYPRLVD-----------------
------LNLAGEPTEGAPVA------------------------------------------------------------
----------VQRDYGFWCPRELKIDPDL-------------------GYSFLHVR---------DCSPPCP-------N
MYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPA-
-----------------------------------QYKASTVTQGSHNKACTMLFMILYFFTMAGSVWWVILTITWFLAA
VPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII
SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQE-----RCRE-----
-YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKE---
IVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMVDD-
-------------QRSKAG---SIHSKVSSYHGSLHRSRDGR----------------YTPCSYRGMEERLPHG------
-------------SMSRL-TDHSRHSSSHRLNEQSRHSSIRDLSNNPMTHIT-HGTSMNRVIEEDGTSA-----------
-------
>Homo_sapiens_(Human)FZD4(Chromosome_11:_86656721-86666433)
--------------------------------------MAWRGAGPSVPGAPGGVGLSLG---LLLQLLLLLGPARGFGD
E-E-----------------------------------------------------ERRCDPIRISMCQNLG--------
--YNVTKMPNLVGHELQTDAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGP--CGGMCLSVKRRCEPV
LKEFGFAWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------
-----------VPLPHKT--------------------------------------------------------------
-----------PIQPGEECHSVGTNSD---------------------QYIWVKRS--------LNCVLKCGYD----AG
LYS-RSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF----
---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV
ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADD---------------
---------------------------------SNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQK--CSNRLV----
--------------------------------------------------NSGKVKR-EKRGN------GWVKPGKGSET
VV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD5(Chromosome_2:_208627310-208634287)
------------------------------------------MARPDPSAPP-----------SLLLLLLAQLVGRAAAA
SKAPV------------------------------------------------------CQEITVPMCRGIG--------
--YNLTHMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPP--CRSVCERAKAGCSPL
MRQYGFAWPERMSCD----------------------------------RLPVLGRDAEVLCMD------YNRSE-----
----ATTAPPR-PFPAKPTLPGP--------------------PGAPASGGECP--------------------------
--------AGGPFVCKCREPFVPILKE------------------SHPLYNKVRTG------QVPNCAVPCYQP------
-SFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVAC------
----------------------------------SREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAA
GMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFV
SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCA--------------
-----CPGHD-----------TGQPR-----AKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPR--
--RGHKSGGAMAA---------------------------GDYPEAS---AALT-GRTGPPGP----AATYHKQVSLSHV
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD6(Chromosome_8:_104310661-104345045)
----------------------------------------------------------MEMFT-FLLTCIFLP-LLRGHS
LFT--------------------------------------------------------CEPITVPRCMKMA--------
--YNMTFFPNLMGHYDQSIAAVEMEH--FLPLANLECSPNIETFLCKAFVPTCIEQIHVVPP---CRKLCEKVYSDCKKL
IDTFGIRWPEELECD----------------------------------RLQYCDETVPVTFD-----------------
------PHTEFLGPQKKTEQ------------------------------------------------------------
----------VQRDIGFWCPRHLKTSGGQ-------------------GYKFLGID---------QCAPPCP-------N
MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEK-
-----------------------------------LELGDTVVLGSQNKACTVLFMLLYFFTMAGTVWWVILTITWFLAA
GRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGII
SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSD-----HCRQ-----
-YHIPCP--------------YQAKA----KARPELALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKRNRKRDP--
-ISESRRVLQESCEFFLKHNSKVKHKKK--------------HYKPSSHKLKVISKSMGTSTGAT-ANHGTSAVAITSHD
Y----------LGQETLTEIQTSPETSMREVKADGASTPRLREQ------------DCGEPASPAASISRLSGEQVDGKG
Q--------AGSVSESAR--SEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVSGVRKEQGGGCHSDT-
-------
>Homo_sapiens_(Human)FZD7(Chromosome_2:_202899310-202903160)
----------------------------------------MRDPGAAAPLSS-LGLCALV------LALLGALSAGAGAQ
PY--------------------------------------------HGEKGISVPDHGFCQPISIPLCTDIA--------
--YNQTILPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLDQAIPP--CRSLCERARQGCEAL
MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDGS---
----GGPGGGPTAYPTAPY------------------------LPDLPFTAL----------------------------
--PPGASDGRGRPAFPFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPGRAN-GL
MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAHVAGFLLEDRAVCVERF---
----------------------------------SDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFREHWERTWLL-----QTCKS-----
-YAVPCPPG-------------HFPP-----MSPDFTVFMIKYLMTMIVGITTGFWIWSGKTLQSWRRFYHRLSHSSK--
--GET----------------------------------------------AV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD8(Chromosome_10:_35927177-35930362)
----------------------------------------MEWGYLLEVTSL-----------LAALALLQRSSGAAAAS
AKELA------------------------------------------------------CQEITVPLCKGIG--------
--YNYTYMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPP--CRSVCERAKAGCAPL
MRQYGFAWPDRMRCD----------------------------------RLPEQG-NPDTLCMD------YNRTD-----
----LTTAAPSPPRRLPPPPP--------------GEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGK
ARPPGGGAAPCEPGCQCRAPMVSVSSE------------------RHPLYNRVKTG------QIANCALPCHNP------
-FFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPG
AGGAGGAGG-AAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAA
GMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFV
SLFRIRSVIKQQD---GPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCP--------------
-----CLRDL-----------QPDQA-----RRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWASK--
--GAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVS---TGLT-WRSGTASS-----VSYPKQMPLSQV
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD9(Chromosome_7:_72848109-72850450)
-----------------------------------------------MAVAP-LRGALLLWQLLAAGGAALEIGRFDPER
GRG-----------------------------------------------------AAPCQAVEIPMCRGIG--------
--YNLTRMPNLLGHTSQGEAAAELAE--FAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPA--CRPMCEQARLRCAPI
MEQFNFGWPDSLDCA----------------------------------RLPTRNDPHALCMEAP-----ENATAGPA--
EPHKGLGMLPVAPRPARPP-------------------------------------------------------------
----------GDLGPGAGGSGTCENPE---------------------KFQYVEKS--------RSCAPRCGPG----VE
VFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACD-----
---------------------------------QEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAA
GKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFV
ALFHIRKIMKTGG-----TNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGG----
--RRDCSLPGG--------------------SVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQS-LCYRKIA-A--
--------------------------------------GRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPT
HL------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Homo_sapiens_(Human)FZD10(Chromosome_12:_130647004-130650284)
-------------------------------------------------MQRPGPRLWLVLQVMG---SCAAISSMDMER
PG------------------------------------------------------DGKCQPIEIPMCKDIG--------
--YNMTRMPNLMGHENQREAAIQLHE--FAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPA--CRVMCEQARLKCSPI
MEQFNFKWPDSLDCR----------------------------------KLPNKNDPNYLCMEAP-----NNGS-----D
EPTRGSGLFPPLFRPQRPHSAQE---------------------------------------------------------
----------HPLKDGGPGRGGCDNPG---------------------KFHHVEKS--------ASCAPLCTPG----VD
VYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACD-----
---------------------------------RDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAA
GKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFV
ALFHIRRVMKTGG-----ENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMN-NQTK----
--TLDCLMAA---------------------SIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQ-VCSRRLK----
--------------------------------------KKSRRKPASVITSGGIYKKAQHPQK---THHGKYEIPAQSPT
CV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Hydra_magnipapillata(Hydra)FZD1ACC54556
---------------------------------------------MRRNLYLHILKSVIIHLLCLNLIFCEPRGIRERYE
TRK--------------------------------------------------------CEKLSITMCEKVG--------
--YNLTFMPNKHGHVNQIDAGQLIRQ--FAPLVAINCSPLLAHFVCSLYAPMCDPVYNKDIVP--CQSLCENIRNSCEKF
MKQNGYTWPDNLQCS----------------------------QFPTREKDPICMKPDFDFPEPS---------------
-----IPTHLNLPDENKKTS------------------------------------------------------------
----------LIQTKDVFKIRDFSGCGCLC------------------KYPFVSVNSSSNTDLFPPCVLPCG-------Q
YFFSNTQNIFMKFWLSLWSILSLITTAVTLLTFLIDRTKFKFVEQPIILISFCYFIVSFGYIIRLIY--GFKAIACNDH-
-------------------------------------TGFLHYASTGPASCTAVFILTYFFTNVSWIWWVVLSINWFLSS
GLKWTNGTISSYSQYFHFVAWLIPTIQTMAILAMSAIDGDPVSGLCTVGNHDSNTLTIFVIGPLLIYTMLSLSFFIAGVV
AKLRIEQTIR-----NEAKNNLKSGRFLSRVGMFTLILFVPAVSLLGCYFYEHSYKEIWEK-------------------
---------------------STNCDCMPIKKQPIFYIFLFKYLMSLVIGIAIGLGTLNSDALGAWRRFFKRHCKITK--
--------------------SLAQEKNG-----------------------QLIPNNSKKGVAI----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Anolis_carolinensis_(Lizard)FZD2(Chromosome_6:_63838547-63840229)
-------------------------------------------MRLHHDASLAR-SPLVF------FFLLLLL--CSCWA
QFH--------------------------------------------GEKGISIPDHGFCQPISIPLCTDIA--------
--YNQTIMPNLLGHTSQEDAGLEVHQ--FYPLVKVQCSPELKFFLCSMYAPVCT-VLEQAIPP--CRSICERARQGCEAL
MNKFGFQWPERLRCE----------------------------------NFPRHGTE-QICVGQ-------NHSEEG---
----ASPALVTSATPIAGHGTVG---------------------------------------------------------
------PPRYATLDHPFHCPRVLKVP-------------------TYLNYKFLG---------EKDCAAPCEPAKSD-GH
MFFNQEEIRFARIWILIWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLEERVVCNERF---
----------------------------------QDDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNNIDPLRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHGG-----TKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWIS-----QNCKS-----
-LAIPCPLQY-------------TPR-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSKH--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Anolis_carolinensis_(Lizard)FZD3(Scaffold_GL343529.1:_88496-124332)
--------------------------------------------------------MAANWVMQFIWPLAVLVGCTSGHS
LFS--------------------------------------------------------CEPIILRMCQDLP--------
--YNSTFMPNLLNHYDQQTAALAMEP--FHPMVNLECSREFRPFLCALYAPVCMEYGRVTLP---CRRICQRAYNDCSKL
MEMFGVSWPEDMECS----------------------------------KFPDCDEPYPRLVD-----------------
------LNVVGESTEEAPVA------------------------------------------------------------
----------VQRDYGFWCPRELKIDPDL-------------------GYTFLRVR---------DCSPPCP-------N
MYFRREELAFARYFIGVISIVCLSATLFTFLTFLIDVTRFRYPERPIIFYAVCYMMVSLIFFIGFLLEDRVACNASSPT-
-----------------------------------TYKASTVTQGSHNKACTMLFMVLYFFTMAGSVWWVILTITWFLAA
VPKWGSEAIEKKALLFHTSAWGIPGTLTIILLAMNKIEGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGII
SLNRVRIEIP-----LEKENQDKLVKFMIRIGVFSVLYLVPLLVVIGCYFYEQAYRGVWETTWIQE-----RCKE-----
-YHIPCP--------------YQVTQ----MSRPDLILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFFHGRRKKD---
VVNESRQVLQE-PDFAQ---SLLRDPNT-----------------------PIIRKSRGTSTQGTSTHASSTQLAMMDD-
-------------QRSKAG---SVHSKVSSYHGSLHRSRDGR----------------YTPCSYRGIEDRLPHG------
-------------SMSRL-TDHSRHSSSHRLNDQSRHGSARDLSGNPTTHIT-HGTSMNRVIEEDGTSA-----------
-------
>Anolis_carolinensis_(Lizard)FZD4(Chromosome_3:_200019382-200029207)
----------------------------------------KADGGAGGWAMAPGGRLLLG---LLWAALVSGEGARGFGD
E-E-----------------------------------------------------ERRCDPIRIPMCQNLG--------
--YNVTKMPNLVGHDLQTDAELQLTT--FTPLIQYGCSSQLQFFLCSVYVPMCTEKIDIPIGS--CGGMCLSVKRRCEPV
LKEFGFSWPESLNCS----------------------------------KFPPQNDHNHMCMEGP-----GDEE------
-----------VPIHSKT--------------------------------------------------------------
-----------PLHPGEECHSVGANSD---------------------QYIWVKRS--------LNCVLKCGYD----AG
LYS-RSAKAFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDF----
---------------------------------EEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLV
ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWTIFRYSADD---------------
---------------------------------SNMAVEMLKIFMCLLVGITSGMWIWSAKTLHTWQK--CSNRLV----
--------------------------------------------------NSGRVKRGEKRAN------GWVKPGKGNET
VV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Anolis_carolinensis_(Lizard)FZD5(Scaffold_GL343343.1:_194929-197396)
----------------------------------------PLPPPPAPPPRR-----------PFLLLAHIQERARASSS
SKAVT------------------------------------------------------CQEITVPMCKGIG--------
--YNLTYMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSPDLKFFLCAMYTPICLLDYAKPLPP--CRSVCERAKAGCSPL
MRQYGFAWPERMGCD----------------------------------KLPLLG-DAEQLCMD------YNRTEAAPAS
A---TTTFPPIGTKPTRSKAKGG--------------------YKEKAPFDSSS--------------------------
--------GTCKRVCECREPLVPISKE------------------THPLYNKIETG------HVRNCAIPCFQP------
-YFTQHEKTFATFWIGLWSVLCFVATFATVATFLIDMERFRYPERPIIFLSACYLFVSIGYIIRLVVGHANVAC------
----------------------------------NKDYNHIHYETTGPALCTVVFLLIYFFGMASSIWWVILSLTWFLAA
GMKWGNEAIASYSQYFHMAAWLIPSIKSIAVLALSSVDGDPVAGICYVGNQNLDKLRGFVLAPLVVYLFTGTMFLLAGIV
SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTVLYTVPATIVVGCYIYEQHYRETWEMAQNCS--------------
-----CPG--------------DKNR-----LRPDYAVFMLKYFMCLVVGITSGVWIWSGKTFESWKRFTGRCCR-----
------SGKPVSS---------------------------AMYGEAT---AALT-GRSGMPSS-----ASYHKQVPLSHV
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Anolis_carolinensis_(Lizard)FZD6(Chromosome_4:_13723379-13739450)
----------------------------------------------------------MTTIH-LLLTWSLIFSLAHGHS
LFT--------------------------------------------------------CEPIHIPRCTAMA--------
--YNMTFFPNIMGHYDQYTAAIHMKP--FLPLMNIECSPDVCTFLCKAFVPLCVEPARVIHP---CRSLCERVYSDCKKY
MDTFGITWPEELECN----------------------------------RLEDCDETAAVTPS-----------------
------VTTRAHGTRKTLRQ------------------------------------------------------------
----------PRRDYGFWCPRHLQTSRGQ-------------------SYKFLGID---------QCAPPCP-------N
MYFSDHELDVATSFIGIVSIFCLCATLFTFLTFLIDVKRFRYPERPIIYYSVCYSIVSLVYFLGFLLGNRIACNQIDEK-
-----------------------------------LQLSATVVLGSQNKGCTIVFMALYFFTMAGTVWWVILTVTWFLAA
GRKWSCEAIEQKAMWFHAVAWGMPGFLTVMLLAMNKVEGDNISGVCFVGLYDLDTSRFFVLLPLCLCVFVGLSLLLAGII
SLNHVRQVIQ-----HDGRNQEKLKKFMIRIGVFSGLYLVPLVMLLGCYIYEQVYRKIWEITWVYD-----HCDE-----
-FHIPCP--------------YQVKT----LARPEIFLFLMKYLMTLIVGISPVFWVGSKKTCSEWANFFNRNRKRDP--
-ISESRRVLQESCEFFLKHNSTTKHRKK--------------HYKSSSHKLKVISKSMGTSTGVT-TNHGTSAVAIANHD
Y----------LSQETFTEIKSCPGSSEKNLEADGAPSQKVEEELA----------HSVQSGLSMGTSPKVPLEHLEKTS
KADN--VQNIS-FSESMKRAAEGRTTPKSDFIEALPLQISHPPLDVSQAG-SLKGSASLFAHSSSDSRKAQESGHSSNG-
-------
>Anolis_carolinensis_(Lizard)FZD7(Scaffold_GL343208.1:_4038808-4040586)
----------------------------------------LLPPPLASSSSP-MPRAPAMG-LWGLLALSWMMPHASRGQ
PASS---------------------------------------SSSQGEKGISVPDHGFCQPISIPLCTDIA--------
--YNQTILPNLLGHTSQEDAGLEVHQ--FYPLVKVQCSPELRFFLCSMYAPVCT-VLEQAIPP--CRSLCERARHGCEAL
MNKFGFQWPERLRCE----------------------------------NFPVHGAG-EICVGQ-------NTSDTSSSS
GGERRGAGVAPGSPATASYPTAH--------------------LPGPPAHPL----------------------------
--PP----TTGHAVFEFSCPRQLKVP-------------------PYLGYRFLG---------ERDCGAPCEPDLPNVGL
MYFKQAEVRFARLLIGIWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVAYVAGFLLEDRVVCVERF---
----------------------------------SEDGFRTVVQGTKKEGCTILFMILYFFGMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQVDGDVLSGVCYVGLYSVDALRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVLACYFYEQAFRDTWEKTWLL-----QNCKS-----
-YAITCPAA-------------NFAP-----MSPDFTVFLIKYLMTMIVGITTGFWIWTGKTLQSWRRFYHRLSTGSK--
--GET----------------------------------------------AV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Anolis_carolinensis_(Lizard)FZD8(Chromosome_6:_10678703-10680740)
---------------------------------------RARFPSPSMDRSL-----------LLALLALLPAS-ASASS
SASLS------------------------------------------------------CQEITVPLCKGIG--------
--YNYTSMPNQFNHDTQDEAGLEVHQ--FWPLVEIQCSSDLRFFLCSMYTPICLEDYKKPLPP--CRSVCERAKAGCAPL
MRQYGFAWPDRMRCD----------------------------------RLPAQG-DPDTLCMD------YNRSE-----
----AATTPPPAPPPQAPPPP------------------PPRAPPRKPLPPLPP--------------------------
--TPPGAPPLCKPDCGARGDARALLPC------------------SRQG-------------RIPNFPWPARI-------
-LLHPNERAFTAFWIGLWTIICFLSTFATVSTFLIDMERFKYPERPIVFLAACYLFVSLGYLVRLVAGHEKVACSAGA--
--------------------------------------EHVRYESTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAA
GMKWGNEAIASYAQYFHLAAWLLPSVKSIAVLALSSVDGDPVAGICYVGNQSLENLRGFVLAPLLIYLAIGSMFLLAGFV
SLFRIRSVIKQQG---GPTKTHKLEKLMIRLGLFTVLYTVPAASVVACLFYEQHNRPRWEATHNCP--------------
-----CLRDQ-----------QPDQA-----RRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWKALCTRCCWASK--
--AAAVGGLGGG--------------------------AGSMYSDIS---TGLT-WRSGTASS-----VSYPKQMPLSQV
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Anolis_carolinensis_(Lizard)FZD10(Chromosome_LGb:_173812-175467)
------------------------------------------------------------------------------ER
PG------------------------------------------------------ESRCQPIAIPMCQDIG--------
--YNVTRMPNLMGHEDQREAAIQLHE--FAPLVEYGCHGHLRFFLCSLYAPMCTEQVSAPIPA--CRVMCEQARLKCSPV
MEQFTFRWPDSLDCS----------------------------------RLPSKNDPNFLCMEAP-----SNGS-----E
EPPK-PGPLPPLFRPHRP---HE---------------------------------------------------------
----------HEP-PPPKGVPSCGNPG---------------------KFRRVEKS--------ASCAPLCSPG----VD
VYWSRQDKRFAAVWIGVWSVLCFFSSAFTVLTFLVDPQRFKYPERPIIFLSMCYCVYSLGYLIRLFSGAESVACD-----
---------------------------------RDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVILTLTWFLAA
GKKWGHEAIEANSSYFHLAAWAVPAVKTIVILVMRRVAGDELTGVCYVGSMDVDALTGFVLVPLACYLVIGTSFILSGFV
ALFHIRRVMKTGG-----ENTAKLEKLMVRIGVFSVLYTVPATCVIACYFYERLNMDYWKVLAMQQKCKVNGNQTK----
--HLDCTMSK---------------------SIPAVEIFMAKVFMLLVVGITSGMWIWTSKTLQSWQN-VCSQRLK----
--------------------------------------KRTRRKPASVIASSGLYQKTQHPPK---GHHTKYESALQPPT
CV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Oryzias_latipes_(Medaka)FZD1(frizzled7)(Chromosome_21:_18907323-18910690)
---------------------------------------------IFARRYSPAFFATFF------VFTPRLCMPAASAQ
HY---------------------------------------------SDSGISVPEHGFCQPISIPLCTDIA--------
--YNQTIMPNLLGHTNQEDAGLEVHQ--FYPLVKVQCSTELKFFLCSMYAPVCT-VLEQAIPP--CRSLCERARQGCEAL
MNKFGFQWPERLHCE----------------------------------AFPVNGGS-EICVGQ-------NTSEPG---
-------SPSSSS-PHVPE------------------------LVTVPPNR-----------------------------
--FPNPPQPPHNSYHQFSCPLQLEVP-------------------SYLGYRFMG---------VKDCGAPCEPTKPS-GI
MYFREDEVKFGRLWVGIWSILCCVSTLFTVLTYLVDMRRFRYPERPIIFLSGCYFMVAVAYAAGFFLEDKVVCVDKF---
----------------------------------KGEGFRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWFLSA
GMKWGHEAIEANSQYFHLAAWAVPAIKTITILAMGQVDGDVLTGVCFVGIFNVDALRGFVLAPLFVYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERTWHM-----QTCKR-----
-FAVPCPVH-------------NFAP-----MTPDFTVFMIKYLMTMIVGITSGFWVWSGKTLQSWRRFYKRLGNGNH--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Oryzias_latipes_(Medaka)FZD2(Chromosome_8:_6503962-6505738)
--------------------------------------------RKGRRLLFRSETPRSS------LWFLCLT--AVISA
QHQ--------------------------------------------GDDGLMLPPHGFCQQISIPLCTDIA--------
--YNQTIMPNLMGNHNQEDAGLEVHQ--FFPLVKVQCSPELKFFLCSMYAPVCT-VLEKPIPP--CRPICEKARQGCEAL
MNKFGFQWPEKLRCE----------------------------------NFPLLGDHGQICVGQ-------NESSSP---
------------TAPPPLPPAPGTR-------------------------------------------------------
-----ELPRVSTHERPFTCPSVLRVP-------------------PYLNYHFLE---------EKDCGAPCESPRNG-GN
MFFSDKEIHFARMWVLIWSVLCCTSTFFTVTTYLIDMQRFRYPERPIIFLSGCYTMVSIAFIAGYFLGDKVACNDSF---
----------------------------------NPDGYKTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAA
GMKWGHEAIEANSQYFHLAAWAVPAVKTISILAMGQIEGDVLSGVCFVSLSNLDPLRGFVLAPLFIYLFIGTSFLLAGFV
SLFRIRTIMKHDG-----TKTEKLEQLMVRIGVFSVLYTVPATIVIACFFYEQAFRPHWERSWVS-----RNCRS-----
-LAIPCPAQS-------------RPH-----MTPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTSGKN--
--GET----------------------------------------------TV---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Oryzias_latipes_(Medaka)FZD3(Chromosome_24:_12909727-12925641)
----------------------------------------------------MDALWVLSLSMLTACVAIPMDAAAGSHS
LFT--------------------------------------------------------CEPITLRMCQELP--------
--YNATFMPNIMNHYDQQTAALAMEP--FHPMVNLRCSPDLRMFLCALYAPVCTEYGRMTLP---CRRLCLQAKSDCYKL
MEMFGVSWPDEMDCI----------------------------------RFPDCDDPYPRPAD-----------------
------LLSSSDTT-ESPIS------------------------------------------------------------
----------VQRDYGFWCPRELKISPEL-------------------GYSFMGVR---------DCSPPCP-------N
MYFTREELAFARYFIGVVSIVCLSATLFTFLTFLIDVARFRYPERPIIFYAVCYMMVSLVFFLGFLLENKVSCNTASPG-
-----------------------------------KFRASTVTQGSHNKACTLLFMVLYFFTMAGSIWWVILTITWFLAA
VPKWGSEAIEKKALLFHACAWGVPGILTVTLLAMNKIEGDGMSGVCFVGLYDLTALRWFLLAPLGLDVVVGVVLLLAGIA
ALNRVRMEIP-----LEKENREKLVKFMIRIGVFSVLYLVPLLTVLACYLYESSYRALWETSWVQR-----ECRR-----
-YHIPCP--------------YQVER----TSHPDLVLFLIKYLMMLVVGIPSVFWVGSKKTCFEWASFFNGKRRKQ---
MVNDSRQVLQE-PDFAQ---LLYRDPNT-----------------------PIVRKSRGTSTQGTSTHASSTHLAMLDEP
----------PSGSTSRAGSVRSARSKMSSYHGSLHRSRDGR----------------YTGSSFRAPNDRPPFGSLPRLN
AQSR-------HCSTNRL-DSLSRHGSTLRLESQSQHSSIRDLSPATQAVLS--GNGIRRVMEEDGA-------------
-------
>Oryzias_latipes_(Medaka)FZD4(Chromosome_13:_20982376-20988350)
---------------------------------WPRVGPGNPTPAPGLVRLSAGALLLLLR-----ALC----AVNAFGD
EME-----------------------------------------------------EMTCDPIRISMCQGLG--------
--YNVTKMPNLVGNMLQSDAELQLTT--FTPLIQCGCSSQLKFFLCSVYVPMCTDKVPIPIGP--CGSMCLSVKRKCLPV
LLEFGYTWPEALNCS----------------------------------RFPPQNDHNHMCMEGP-----GDED------
-----------PPYQSVH--------------------------------------------------------------
-----------HPSDQ-DCQALDSTPD---------------------QYTWLKQT--------ESCVLQCGYD----NG
LYR-RGAKVFTDAWMAVWAVLCFLSTTLTVLTFLLDSQRFSYPERPIIFLSMCCNLYSVAYLVRLTLGRERVSCDL----
---------------------------------DAVGVPVLVQEGLKSTGCAIVFLLLYFFGMASSLWWVILTLTWFLAA
GLKWGHEAIEMHSSYFHIAAWAIPAAKTIVILIMRLVDADDLTGLCYVGNQQQEALTGFVVAPLATYLLVGTLFICAGLM
ALFKIRSNLQKDG-----TKTDKLERLMVKIGVFSILYTVPASTVIGCYLYQLSHWGEFKTSTHD---------------
---------------------------------SYVTSEMLRIFMSLLVGITSGMWIWSAKTLHTWQR--CSSRLL----
--------------------------------------------------REGHVGRGGKSAPG----EGWIKPGKGNET
VV------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Oryzias_latipes_(Medaka)FZD6(Chromosome_16:_1120316-1132396)
-------------------------------------------------------------PL-WLGLALVWVGSCRAHS
FFT--------------------------------------------------------CEPIKVHRCMGMP--------
--YNMTFFPNMMEHYDQEIAASKMEP--FMPLANLRCSPDVHHFLCQAFIPACTEDNRVIRP---CREKCRAVLSDCREN
IRIFDVTWPPELQCD----------------------------------K---LDPCVVDGSV-----------------
------PPTTA--QQTPSS-------------------------------------------------------------
----------PKRDLGFWCPLQLKTKAGQ-------------------GSSFLGTQ---------DCAPPCS-------N
MFFKPHDIEFAKSFIGVCSIICLCATLFTFLTFLIDVKRFRYPERPIIFYAVCYSFVSLIYFIGFLLGDSAACAKASHH-
-----------------------------------AAV-DTVVLGSQSKGCTLLFMLLYFFTMAGMVWWVILTITWFLAA
GPKWSCEAIEKKAVWFHSAAWGIPGALTVMLLALNKVEGDSISGVCFVGLYDLDALRYFVLAPLCVGVIVGLILILAGIV
SLNHVRQVIQ-----HDERNQEKLKKFMIRIGVFSCLYLLPLVTLLACYTYEQSHRSSWENTWIND-----RCQE-----
-YSIPCS--------------YKTAT----PDRPDLSLFLVKYLMTLVVGISAVFWVSSKKTCSEWAYFFNRTRKRDP--
-ISESRRVLQESCEFFLKHNTRVQHKKK--------------HYKSSSHKLKVISKSMGTSTGAAPTNAGTTSSS-GNHE
T----------LLEGSLSDTLVR--EQMDRTTAARSSRRGEREG--------------GERRSKGGSSSRISSHSESVHR
AADG--RWDETSRSHSER--------------------------------------------------------------
-------
>Oryzias_latipes_(Medaka)FZD8(Chromosome_20:_6877160-6878737)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------DTQDEAGLEVHQ--FWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPP--CRSVCERARAGCAPL
MRQYGFPWPDRMRCD----------------------------------LLPVQG-NPDTLCMD------YNRND-----
----STTASPVLSKPTNHPGRSP-------------KSKPGRAGA---PGKYKP--------------------------
------PAAPCEPGCRCLEPMVAVTTE------------------RHPLYNRVKTG------QVTNCAMPCHNP------
-YFTHDERAFTAFWIGLWSVLCFVSTFATVATFLIDMERFKYPERPIIFLSACYMFVSVGYIVRLIAGHEKVACNR----
---------------------------------DFDVEH-IHYETTGPALCTIVFLLIYFFGMASSIWWVILSLTWFLAA
GMKWGNEAIASYAQHFHLAAWLIPSMKSIAVLALSSVDGDSVAGICYVGNQNLDNLRGFVLAPLVIYLFIGTMFLLAGFV
SLFRIRSVIKQ-----GGTKTDKLEKLMIRIGIFTVLYTVPATVIVACYFYEQHNRQDWEMTHNCSS-------------
-----CLMER-----------ERARS-----G-PDYAVFMLKYFMCLLVGITSGVWIWSGKTLDSWRTFCTRCCWGSK--
--GT----------------------------------GGSMYSDAS---TGLT-WRSGTASS-----VSCRKQMPLS--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------
>Oryzias_latipes_(Medaka)FZD9(Chromosome_13:_21969998-21971728)
----------------------------------------------------------FLWALLPVSASSLEMSFYDLER
DR------------------------------------------------------PAKCEPIVIPMCVGIG--------
--YNLTRMPNFMDHDDQAEAAIKLQE--FAPLVDYGCDVHLRFFLCSLYAPMCTDKVSTSIPA--CRPMCEQARDKCAPI
MKKFSYTWPDSLDCS----------------------------------KLPTRNDPNALCMEAP-----ENETRTEGKK
DKKKGEGMLPVPPRPRQPD-------------------------------------------------------------
----------TPSSRLPGSGNSCENPD---------------------KFQFVEKS--------QSCAPRCSPA----VD
VYWSRQDKDFAFIWMTVWSILCFVSTAFTVLTFLLEPHRFQYPERPIIFLSMCYMVYSLAFIIRSVAGAENIACD-----
---------------------------------REHGELYIIQEGLESTGCTIVFLILYYFGMASSIWWVILTLTWFLAA
GKKWGHEAIEAHSNYFHMAAWGIPALKTIVILTMRKVAGDELTGLCYVGSMDSGALTGFVLIPLSCYLIIGTSFILTGFV
ALFHIRKVMKTEG-----TNTEKLEKLMVKIGIYSILYTVPATCVIVCYFYERLNMDYWKLRGLQEECDSFSSH-