>Homo_sapiens-HDAC4(ENSP_264606)
---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA
TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------NSSGSVSAENGIAPAVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN
ITLG---LPATGPSAGTAGQ------------------------------------------------------------
------------------QDAERLTLPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP
LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LQMNK
IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------QA-GVQVKQEPIESDEEE
AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS
---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAVAAKLLQQRLS----VSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVMEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRCLQRTTSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE
PMEEEPPL---------------------------------------------------------------
>Macaca_mulatta-HDAC4(ENSMMUP_7984)
----------------------------------------------CLLSSPDGLSGRDQPVELLNPARVNHMPSTVDVA
TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------NSSGSVSAENGITPAVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN
ITLG---LPATGPAAGTAGQ------------------------------------------------------------
------------------QDAERLTLPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP
LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHMNK
IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPAQKEAHA-------------PA-GVQVKQEPIESDDEE
AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP
LSRAQSSPASAT---FPVSVL--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS
---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPIYATCRLQLLGVECRCRGLRAS----LLAQTRVRWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GAPD
EVGLHARVSPDSNFSQTSACVAPRGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVMEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRCLQRATSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-ADEE
PMEEEPPL---------------------------------------------------------------
>Pan_troglodytes-HDAC4(ENSPTRP_22412)
---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA
AALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------NSSGSVSAENGIAPTVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN
ITLG---LPATGPSAGTAGQ------------------------------------------------------------
------------------QDAERLALPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP
LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LQMNK
IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------QA-GVQVKQEPIESDDEE
AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS
---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELK---------------
--------------------------------------------------------------------------------
------------------------------------TVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVMEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRCLQRTTSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE
PMEEEPPL---------------------------------------------------------------
>Gorilla_gorilla-HDAC4(ENSGGOP_26804)
---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA
TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------NSSGSVSAENGIAPTVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN
ITLG---LPATGPSAGTAGQ------------------------------------------------------------
------------------QDAERLALPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP
LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LQMNK
IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------PA-GVQVKQEPIESDDEE
AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS
---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVTTG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAVAAKLLQQRLS----VSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--G??P
QVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVMEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRCLQRTASTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE
PMEEEPPL---------------------------------------------------------------
>Callithrix_jacchus-HDAC4(ENSCJAP_51829)
---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA
TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCLSS-DPRYWYGKTQHSSLDQSSPPQS---GVSA
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------NSSGNVSAENGISPAVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN
ITLG---LPATGPSAGAAGQ------------------------------------------------------------
------------------QDAERLALPTLQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP
LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHMNK
IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPG-KEAHP-------------QG-GVQVKQEPIESDDEE
AEPPQEVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP
LSRAQSSPASAT---FPVSVQ--EPPAKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS
---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPLGHHAE
ESTPMG-FCYFNSVAVAAKLLQQRLS----VSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVMEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRCLQRAASTAGRSLIEAQTCE-----NDEAETVT-AMASLSVG-VKPA-------EKR-PDEE
PMEEEPPL---------------------------------------------------------------
>Pongo_pygmaeus-HDAC4(ENSPPYP_14905)
---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA
TALPLQVAPSA----------VPMDLRLDHQ------FSLPVAEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVST
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------NSSGSVSAENGITPTVPSIPAETSLAHRLVA--REGSAAPLPLYTSPSLPN
ITLG---LPATGPSAGTAGQ------------------------------------------------------------
------------------QDAERLALPALQQRLS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHSP
LLQHMVLLEQPPAQAPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHMNK
IIPKPSEP--ARQPESHPEETEEELREHQALLDEPYL-DRLPGQKEAHA-------------PA-GVQVKQEPIESDDEE
AEPPREVEPGQRQPSEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAT---FPVSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGSS
---SSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLASVFVRLPCGG---VG-VDSDTIWNEVHSAGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTP-----------------------------------DVHHGNG-TQAFYSDPSVLYVSLHRYDDGNFP-----GSAD
EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVMEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRCLQRATSTAGRSLIEAQTCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-PDEE
PMEEEPPL---------------------------------------------------------------
>Mus_musculus-HDAC4(ENSMUSP_8995)
---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA
TALPLQVAPTA----------VPMDLRLDHQ------FSLP-LEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVATALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------SSSGNVSTENGIAPTVPSAPAETSLAHRLVT--REGSVAPLPLYTSPSLPN
ITLG---LPATGPAAGAAGQ------------------------------------------------------------
------------------QDAERLALPALQQRI-----LFPGTHLTP-----------YLSTSPLERDG-----AAAHNP
LLQHMVLLEQPPTQTPLVTG------------------------------LGALPLHSQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLSK
IISKPSEP--PRQPESHPEETEEELREHQALLDEPYL-DRLPGQKEPS--------------LA-GVQVKQEPIESEEEE
AEATRETEPGQRPATEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP
LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDS-
--------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAVAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRLV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPLPEKVLHQRPNANAVHS
MEKVMDIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRCLQRLSSTVGHSLIEAQKCE-----KEEAETVT-AMASLSVG-VKPA-------EKR-SEEE
PMEEEPPL---------------------------------------------------------------
>Rattus_norvegicus-HDAC4(ENSRNOP_27622)
---------------------------------------------MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVA
TALPLQVAPAA----------VPMDLRLDHQ------FSLP-LEPA---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEM----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCMSS-DPRYWYGKTQHSSLDQSSPPQS---GVSA
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVATALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------SSSGNVSTENGIAPTVPSTPAETSLAHRLVT--REGSVAPLPLYTSPSLPN
ITLG---LPATGPAAGAAGQ------------------------------------------------------------
------------------QDAERLALPALQQRIS----LFPGTHLTP-----------YLSTSPLERDG-----GAAHNP
LLQHMVLLEQPPTQTPLVTG------------------------------LGALPLHTQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLSK
MISKPSEP--PRQPESHPEETEEELREHQALLDEPYL-DRLPGQKEPS--------------LA-GVQVKQEPIESEEEE
VEATREAEPSQRPATEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP
LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDS-
--------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPLPEKVLHQRPNANAVHS
MEKVMGIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------EYWRCLQRLSPTVGHSLIEAQKCE-----NEEAETVT-AMASLSVG-VKPA-------EKR-SEEE
PMEEEPPL---------------------------------------------------------------
>Oryctolagus_cuniculus-HDAC4(ENSOCUP_1...
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------LAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAVAARLLQQRLN----VSKILIVDWDVHHGNGTQQAFYSDPSVLYVSLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLDPPMGDTEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEV-----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------
>Bos_taurus-HDAC4(ENSBTAP_23621)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------AS-VPPFLSRKTQHSSLDQSSPPQS---GASA
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSAPSSPN---------NSSGNVSTENGIAPAVPSIPAETSLAHRLVA--REGSVGPLPLYTSPSLPN
ITLG---LPATGPSTGAAGQ------------------------------------------------------------
------------------QEAERLALPALQQRIS----LFPGTHLAP-----------YLGAAPLERDA-----GAAPGS
LLQHVVLLEQPPTQTPLVTG------------------------------LGALPLHAQPLVGAERV-----APSVHKLR
QHRPLGRTQSAPLPQ--------STQALQHLVIQQQ--HQQFLEKHKQHFQ-QPQ--------------------LHLNK
MIPKPSEP--ARQPESHPEETEEELREHQALLEEPFL-DRLPGQKEAHT-------------LA-GVQVKQEPIESDDEE
TEPPREAEPGQRPPTEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAT---FPMSVQ--EPPAKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSETHALLYGTN--PLNRQKLDSK
KLLG----SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLS----VSKTLVVDWDVHHGNGTQQAFYSDPRVLYISLHRYDDGNFFPGS--GAPD
EVGTGAGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIASEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVIEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------QYWRSLQRLASTAGYSLVEAQKCE-----NEEAETVT-AMASLSVA-VKAP-------EKS-PSPR
ARRGEPQP---------------------------------------------------------------
>Canis_familiaris-HDAC4(ENSCAFP_18541)
-------------------------------------------RPGHPSQWCRGGRGRGSPCRCSDRRFCAVLSPTVDVA
SALPLQVAPPA----------VPMDLRLDHQ------FALPVAEPT---LREQ-QLQQELLALKQKQQLQRQILIAEFQR
QHEQLSRQHEAQLHEHIKAGQIKS-------MKVILRCPVATLK--QSRKAQAY---------RSKDSFHALHRRRE--G
EQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA
SYNHP-VLGMYDTKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSAPSSPN---------NSSGNVSAENGITPAVASIPAETGLAHRLVT--REGSVAPLPLYTSPSLPN
ITLG---LPATGPSAGAAGQ------------------------------------------------------------
------------------QDAERLALPALQQRIP----LFPGTHLTP-----------YLSTAPLERDG-----GAAHNP
LLQHMVLLEQTPAQTPLVTG------------------------------LGALPLHAQPLVGADRV-----SPSMHKLR
QHRPLGRTQSAPLPQ--------NAPALQHLVIIQASLKPQRAPEGLRAWR-TES--------------------RAAGR
IIPKQNEP--ARQPESHPEETEEELREHQALLEEPYL-DRLSGQKEAHA-------------LA-GVQVKQEPIESDDEE
AEPPREVEPGQRQPTEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAT---FPMSVQ--EPPTKPEVHHR----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLD----VSKTLIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRPNANAVRS
MEKVIEIHKR----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------QFWRYLPYLCYTVG-SLLDAQKCE-----NEEAADCHPPIVSLFEG-VKTA-------EKRRPDEE
PMEEEPPL---------------------------------------------------------------
>Loxodonta_africana-HDAC4(ENSLAFP_9167)
-------------------------------------------------------------------------PLTVDAV
TALPLQVAPTA----------VPMDLRLDPP------FPLPVAEPA---LREQ-QLQQELLALKQKQQLQRQILIAEFQR
QHEQLSRQHEAQLHEHVKQNE-------------KLTHEQTRCI--HQRNMRKG---------VEDRECSRGHGEAL--S
LQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRS--LNHCISS-DPRYWYGKKKNSSLDQSSPPQS---GVSA
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSGPSSPN---------NSSSNVSSENGITPAVPSIPAETTLAHRLVA--R--EVTQLPLYTSPSLPN
ITLG---LPATGPSAGAAGQ------------------------------------------------------------
------------------QDAERLALPALQQRIP----LFPGTHLAP-----------YLSAAPLERDG-----GAAHNP
LLQHLVLLEQPPPQTPLVAG------------------------------LGTLPLHAQSLVGADRV-----SPSVHKLR
QHRPLGRTQSAPLPQ--------NTQALQHLVMVGL--QEQALHVSQVGLQ-EQA--------------------LHVSR
IISKPSEP--TRQPESHPEETEEELREHQALLEEPCL-DRLPGQKGVHT-------------LA-GVQVKQEPVESDEEE
TEAAREAEPGQRQATEQELLFRQPPPPHPSKPLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAT---FPMSVQ--EPPAKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RSQCECIRGRKATLEELQTVHSEAHALLYGTN--PLNRQKLDS-
--------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAVAAKLLQQRLS----VSRILIVDWDVHHGNGTQQAFYSDPSVLYISLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLTAF--RTVVMPVAVEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSARC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKTLQQRSNANAIRS
MEKVIEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSLQRTASTVGYSLVEAQKCE-----NEEAETVT-AMASLSVG-VKSA-------EKR-PDEE
PMEEEPPL---------------------------------------------------------------
>Equus_caballus-HDAC4(ENSECAP_15097)
---------------------------------------------------------------------LCCALSAVDVA
AALPLQVAPPA----------VPMDLRLDHQ------FSLPVTEPT---LREQ-QLQQELLALKQKQQLQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQEL----------LAMKHQQELLE--HQRKLERH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA
SYNHP-VLGMYDAKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACSSAPGSAPSSPN---------NSSGNVSTENGIAPAVPSIPAETSLAHRLVT--REGSVAPLPLYTSPSLPN
ITLG---LPATGPSAVSRHPR-----------------------------------------------------------
-----------------VGEAERLALPALQQRIS----LFPGTHLTP-----------YLSTAPLERDG-----AAAHNP
LLQHMVLLEQPPAQTPLVTG------------------------------LGALPLHAQSLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQHLVVQQQ--HQQFLEKHKQQFQ-Q---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------
>Ornithorhynchus_anatinus-HDAC4(ENSOAN...
---------------------------------------------AASSSHPEGLFYVEIVVQSPDLAFVFAPPITVDVT
TALPLQVAPSS----------VPMDLRLDHQ------FSMPGSEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQ----------EMLAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRYWYGKTQHSSLDQSSPPQS---GVSA
TYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACNSAPGSGPSSPN---------NSSNNISNENGIAAQMTPAPQVTSLAHRLVN--REGSVTQLPLYTSPSLPN
ITLG---LPATGPSSGGSGQ------------------------------------------------------------
------------------QEAERLAIPTLQQRIS----LFPGTHLTP-----------YLSTTTLERDG-----GTAHNP
LLQHMVLLEQPAAQTPLVTG------------------------------LGALPLHAQTLVGADRV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK
MIPKANEP--SRQHESHPEETEEELREHQALLEEPYS-DRIPNQKEAQA-------------LASMVQVKQEPIESDEED
TELPQEVEQGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGSHRP
LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSVWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDS-
--------SLTSVFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GSPD
EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLTAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRIV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRSNENAVHS
MEKVIEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSLQRFSSTVGYSLIEAQKCE-----NEEAETVT-AMASLSVG-VKQ--------AEKRPDEE
PMEEEPPL---------------------------------------------------------------
>Gallus_gallus-HDAC4(ENSGALP_33098)
-------------------------------------------------------------------------PSAVDVS
TALPLQVAPTS----------VPMDLRLDHQ------FPMPVTEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQ----------EMLAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRFWYGKTQHSSLDQSSPPQS---GVSG
TYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACNSAPGSGPSSPN---------NSSNNISAENGITGSVTSIQAETSLAHRLVN--REGSVTQLPLYTSPSLPN
ITLG---LPATGPSSGGSAQ------------------------------------------------------------
------------------QDAERLAIPALQQRIS----LFPGTHLTP-----------YLSTTTLERDG-----GTAHNP
LLQHMVLLEQPTAQTPLVTDWY----------------------------LSGLPLHAQSLVGGERV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK
IISKPNEP--ARQHESHPEETEEELREHQALLEEPYS-DRVSSQKEVPG-------------LANMVQVKQEPIESDEEE
AEPQQELESGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASLEAAGMPVSFGGHRP
LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLVV--GSISIIYSQHDCLGG-VNV-VDSDTIWNEVHSSGAARLAVGCVIELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD
EVGTGAGVGFNVNMAFTGGLDPPMGDTEYLTAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVLQQRANANAVHS
MEKVIEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWHSLQRYASTVGYSLVEAQKCE-----NEEAETVT-AMASLSVG-VKP--------AEKRPDDE
PMEEEPPL---------------------------------------------------------------
>Taeniopygia_guttata-HDAC4(ENSTGUP_3338)
----------------------------------------------FSPLFPDGLSGRDQPVELLNPPRVNHMPSSVDVS
TALPLQVAPSS----------VPMDLRLDHQ------FSMPVTEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQQ----------EMLAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRN--LNHCISS-DPRFWYGKTQHSSLDQSSPPQS---GVSG
TYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVTGTA-
----DSACNSAPGSGPSSPN---------NSSNNISTENGIAGSVTSIQAETSLAHRLVN--REGSVTQLPLYTSPSLPN
ITLG---LPATGPSSAGQAQ------------------------------------------------------------
------------------QDAERLAIPALQQRIS----LFPGTHLTP-----------YLSTTALERDG-----GTAHNP
LLQHMVLLEQPTAQTPLVTDWY----------------------------LSGLPLHAQPLVGGERV-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK
IISKPPEP--ARQHESHPEETEEELREHQALLEEPYG-ERATGQKEPPA-------------LASVVQVKQEPIESDEEE
AEPQQELESGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASLEAAGMPVSFGGHRP
LSRAQSSPASAT---FPMSVQ--EPPTKPRFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RGKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLL----GSLTSMFVRLPCGG---VG-VDSDTIWNEVHSSGAARLAVGCVIELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD
EVGTGAGVGFNVNMAFTGGLDPPMGDTEYLTAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPTPLGGYNLSAKC--F
GYLTKQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPLPEKVFQQRANANAVHS
MEKVIEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWHSLQRFASTVGYSLVEAQKCE-----NEEAETVT-AMASLSVG-VKP--------AEKRPEDE
PMEEEPPL---------------------------------------------------------------
>Xenopus_tropicalis-HDAC4(ENSXETP_10592)
---------------------------------------------LNSQTSADGISGLDQPVDLLTQTRAKHMPSTVDVS
AALPLQVAPSA----------LPMDLRLDPQ------YTISAQEPG---GREQ-QLQQELLALKQKQQIQRQLLIAEFQR
QHEQLSRQHEAQLHEHIKQQQEL----------LAMKHQQELLE--HQRKLEQH---------RQEQEMEKQQREQK--L
LQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAHRS--LNHCLSS-DPRLCHRKTQHSSLDQSPPPQG---VVSA
SYHQA-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPGITTLKK----RPLDVS----
----DSACNSAPGSGPSSPN---------NSSSNISSENGIAGPLG-IQTEASLAHRLAN--RENSVSQLPLYTSPSLPN
ITLG---LPASGSTNGGSGQ------------------------------------------------------------
-------------------ENECLPLPALQQRLS----LFPAAHLTS-----------YLGP-----EA-----TSSHNQ
LLQHMVLLEQPGAQSSLISG------------------------------LGTLPLHSQSLVSPDRV-----SPTMHKLR
QHRPLGRTQSAPLPQ--------NSHALQHLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLNK
MIPKVNEA--SRQHESHPEETEEELREHQALHEEPYA-ERLAEQKELSP-------------GS-VVHVKQEKEESDDED
NTLELER---SKMQSDPDLLFRQ------QTLLLEQQRIHQLRNYQ-----------------ASLEAAGLVVPFSGHRP
LSRAQSSPASAS---FPMSVQ--EAPSKPRFTT-----------------------------GLVYDTLMLKHQCICGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RSMCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLEGK
TLPS----SLASLFVRLSCGG---VG-VDSDTIWNEVHSSGAARLAVGCVVELASKVVSG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKVLQQRLN----VEKTLIVDWDVHHGNGTQQAFYSDPNVLYISLHRYDDGNFFPGS--GAPD
EVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAF--RTVVMPIAAKFSPDVVLVSA-GFDAVEGHPAPLGGYNVSAKC--F
GYLTKQLMELAGGRVV-LALEGGHDLTAICDASEACVSALLGNKL----------------EPLPESVLQQRPNGNAARS
MENVIQIQS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------EYWPCLHITSSTVAYSLIEAQKCE-----NEEAETVT-AMASLSVD-VRQ---------ERRTEDE
PMDEEPPL---------------------------------------------------------------
>Anolis_carolinensis-HDAC4(ENSACAP_9498)
---------------------------------------------------------------------------AVDVT
TTLPLQVAPTV----------VPMDLRLDHQ------FSIPVAEPT---LREQ-QLQQELLALKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLHEHIKQQ-----------EILAMKHQQELLE--HQRKLEQH---------RQEQELEKQHREQK--L
QQLKNKEKGKES---AVASTEVKMKLQEFVLNKKKALAQRN--LNHCISN-DPRFWYGKTQHSSLDQSSPPQS---GVSG
NYNHP-VLGMYDSKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGPVVTALKK----RPLDVT----
----DSACNSAPGSGPSSPN---------NSSSNISAENGITPSVANIQAENNLAHRLAN--REGSVTQLPLYTSPSLPN
ITLG---LPATAPSSGGSGQ------------------------------------------------------------
------------------QDPERLALPSLQQRIS----IFPGTHIPP-----------YLSSTTVDRDG-----GNAHNP
LLQHMVLLEQPSTQTPLVPG------------------------------LGALPLHAQSLVGADRL-----SPSIHKLR
QHRPLGRTQSAPLPQ--------NAQALQQLVIQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHINK
MIPKPNES--SRQHESHPEETEEELREHQAFLEDPYI-DRISNQKDIQG-------------LTSMVQVKQEPVESDE-D
GEFQPELEPGQRQ-AEQELLFRQ------QALLLEQQRIHQLRNYQ-----------------ASMEAAGIPVSFGGHRP
LSRAQSSPASAN---FPISVQ--EPPCKPQFTT-----------------------------GLVYDTLMLKHQCTCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RSKCECIRGRKATLEELQTVHSEAHTLLYGTN--PLNRQKLDSK
KLLG----SLTSVFVRLPCGG---VG-VDSDTIWNEVHSFSAARLAVGCVIELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAISAKLLQQRLN----VNKILIVDWDVHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGS--GAPD
EVGIGPGAGFNVNMAFTGGLDPPMGDTEYMAAF--RTVVMPIANEFAPDVVLVSS-GFDAVEGHPAPLGGYNLSAKC--F
GYLTKQLMGLAGGRII-LALEGGHDLTAICDASETCVSVLLGNEL----------------DPIPEKVLQQRPNANAVHS
IEKVIEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWHSLQRYASTVSYSLTEAQKCE-----NEEAETVT-AMASLSVG-VKPP-------PDKKPDEE
PMEEDPPL---------------------------------------------------------------
>Danio_rerio-HDAC4(ENSDARP_107448)
--------------------------------------------------------------------------TVDVS-
VALPLQVPPSA----------IPMDLRVDHQ------FALAPTDPA-QREHQ---LQQELLALKQKQQIQRQLLIEEFQR
QHEQLSRQHEAQLQEHVKHQQ----------DLLALKHQQELLE--HQRKLERH---------RQEQEMEKQQREQK--L
QLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNHCLPS-DPRYWYGKTQHSSLDQSSPPQT---GIS-
TYNHP-VLGMYDPKDDFPLRKTASASEPNLKLRSRLKQKVSERRS----SPLLRRKDGP-ITTAKK----RSLDMA----
----ESACSSAPGSGPSSPN---------NSSNNITNENGIAGSISNSAVEPSLAHRLTG--REGPVSQLSLYTSPSLPN
ITLG---LPATGPSS-VASGQ-----------------------------------------------------------
-----------------QDGD-RMAVPGLQPGIPITTPFMPGAHLPS-----------YLAASSLERE-----SGSAHNT
LLQHMVLLEQSAAQNS-------------------------------------LVAGLSG--VPLQS-----HSIHKLRQ
-HRPLGRTQSAPLPQ----N----SQALQQLVVQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHISK
MMVKPSEP--NRQHESHPEETEEELREHQGLGDPADP-------------------------LPHGVTIKQEPPDEQD--
-EDFQQ----RERQAEEELLFRQ-----N-SLLLEQQRIHQLRNYQ-----------------ASMEAAGLSVSFPVHRP
LSRAQSSPASAT---FPIVVQ--EPPAKPRFTT-----------------------------GLVYDTLMQKHQCMCGNS
---NIHPEHAGRIQSIWSRLQETGL-----------RGQCECIRGRKATLEELQTVHSEAHVLLYGTN--PL-RQKLD--
---S----SVTPMFVRLPCGG---IGVVDSDTIWNEVHSSSAARLAVGSVVDLVFKVASG--ELRNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFFPGS--GAPD
EVGIGPGVGFNVNMAFTGGLEPPMGDADYLAAF--RSVVMPIANEFSPDVVLVSS-GFDAVEGHPPPLGGYKLTAKC--F
GYLTKQLMGLAGGRLV-LALEGGHDLTAICDASEACVSALLGNEL----------------DPIPEDILQQRPNANAIQS
MEKVLEVQS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSLQRSVSTLGYSLREAQRCE-----NEEAETVT-AMASLSVAN-KHM-------GK-RPEEE
PMEEEPPL---------------------------------------------------------------
>Oryzias_latipes-HDAC4(ENSORLP_22663)
---------------------------------------------------------------LKAKRLYRLSCLVDVSP
AALPSQVPPTSTA-------ILPMDLRVVDH------HHKKKQTPP-GHQEH--QLQHELVALKHKQQLQRQLLIAEFQR
QHEQLSRQHEAQLQEHIKHQQ----------DLLALKHQQELLE--HHRKMEQQ---------RHDQ-LEKQQREQK--L
QQLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRN--LNHCLPS-DLRYWYGKTHHSSLDQSSPPQT---ALS-
AYNHP-MLGTYDLKDDFPLRKTAS--EPNLKLRSRLKQKVAERRS----SPLLRRKDGL-ITTAKK----RSLDVA----
----EPACNSAPGSGPSSPN---------NSSSNIPNENGIP--ISSSHGEASLLQRLAA--REGSVSQLSLYTSPSLPN
ITLG---LPATGPASAVVSGH-----------------------------------------------------------
-----------------QDGESHLALPALQQGIPLTPPFLPTAHLPS-----------YLAPSALDREGPGGGTAG-HNP
LLQHVVLLEQGHSPMEKHVQG-----------------------------ALCHTVGLAG--LPLPS-----PTVSKLVR
GHRPLGRTQSAPLPQ----QPCGQAQALQQLVVQQQ--HQQFLEKHKQLFQQQQQHLISKIMSKP---------GDPASA
VGSSASLP--GRQHQSHPEETEEELREHQGLSSSSS--SPSSAPMQETR-------------LLR--AIKQEPPDPEE--
QEEREQ----RERHSEPDFLFKQ-----QQTLLLEQQRIHQLRNYR-----------------ATIEDSSLPGTLAGKRP
LFRTQSSPASAS---LPMAVQ--ESPVKHRFTT-----------------------------GLVYDSLMQKHQCICGNS
---TIHPEHAGRIQSIWSRLQETGL-----------RAHCEVIRGRKASPEELQTVHSEAHVQLYGTN--PL-RQRLDCK
TCIS----SVNPVFVRLPCGG---IG-VDSDTIWNEVHSSSAARLAVGSVVELVFKVASG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKILIVDWDVHHGNGTQQAFYADPNVLYLSLHRYDDGNFFPGS--GAPD
EVGSGAGVGFNVNVAFTGGLEPPMADAEYLAAF--RTVVMPIAKEFAPDMVLVSS-GFDAVDGHAPPLGGYKVTSKC--F
GYLTRQLMDLAGGRLV-LALEGGHDLTAICDASEACISALLGNEL----------------EPIPEEVLQQRPNANAVSS
LEKVMETHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSLQRSASTLCCSLSEALQHD-----VEEAETVS-AMASLSVAN-KHI-------GK-RAEEE
PMEEEAAM---------------------------------------------------------------
>Takifugu_rubripes-HDAC4(ENSTRUP_35900)
---------------------------------------------ECALSSTEGILGKEQPLEVLKTSVLNHIPTVDIN-
SALPLRLPPAA----------IPMDLRVDPH------QQQQQVSQ--PSVCDQ-QLQQELLTLKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLQEHIKQQQ----------ELLALKHQQELLE--HQRKMENH---------RMEQELEKQQREQK--L
QLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNQGGPHNDAPYWYRKTQHSSLDQSSPPQT---GVS-
TYNQP-VLGVYNPRDDFPLRKTAS--EPNLKLRSRLKQKVSERRS----SPLLRRRDSP-ITTAKK----RSLDMA----
----DSACSSAPGSGPSSPN---------NSSNNIPSENGVTVSVSNNS-EVSLAQRMCGGAERGSVNQLSLYTSPSLPN
ITLG---LPATATATAASNVT-----------------------------------------------------------
---------------------SAQPDGGLQPALSLSPPFLSGGHLTP-----------YLAEAGAGTGG-----HAAHSP
LLQHMVLMEQSPAQSPLVTGTL----------------------------RLPSHSKTSIHLSKL-------MSSFHMQR
QHRPLGRTQSAPLPQGSAAQAHAQALALQQLVVQQQ--HQQFLEKHKQQFQ-QQQ--------------------LHLNK
MITKPSESPVGRQHQSHPEETEEELREHQDGGALPAG-----------------------------VTIKQEPPDPQELQ
EEVLHRE---RERQAEQQELLFR-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSISFPGHRP
LSRAQSSPASASS--FPISVPASDPPTKPHFTT-----------------------------GLVYDSLMQKHQCMCGNT
---NNHPEHAGRIQSIWSRLQETGL-----------RAQCECIRGRKATLEELQTVHSEAHVLLYGTN--PL-RQKLDCR
LLPG----SITPMFVRLPCGG---IG-VDSDTIWNEVHSSSAARLAVGSVVELVFKVATQ--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----INKILIVDWDVHHGNGTQQAFYDDPSVLYLSIHRYDDGNFFPGS--GAPD
EVGSGPGVGFNVNVAFTGGLEPPMSDAEYLAAF--RSVVMPIANEFAPDIVLVSS-GFDAVEGHPPPLGGYTLTAKC--F
GYLTRQLMTLAGGRLV-LALEGGHDLTAICDASEACLAALLGQEL----------------DPLPKSVLEQRPNVNAVRS
LEKVLEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSVQRYSLHLGLSLLEAKRGD-----SEEAEAVS-AMASLSVANTNAM-------DQSRSEEE
PMEEEEPL---------------------------------------------------------------
>Takifugu_rubripes-HDAC4(ENSTRUP_12899)
----------------------------------------------------------------------LSHFPVDVSA
AALPMQVPPAATA-------ILPMDLRVDHH------HNHQQQPTF-DHQEQ--QLQQELVALKHKQQLQRQLLIAEFQR
QHEQLSRQHEIQLQEHIKHQQ----------DLLALKHQQELLE--HQRKIEQQ---------RHEQELEKQQREYK--L
HQLKNKDRGQES---AIASTEVKMRLQEFVLNKKKALAQRN--LNHCLPS-DPRYWYGKTQHSSLDQSSPPQT---ALS-
AYTHP-MLGTYDSKDDFPLRKTAS--EPNLKLRSRLKQKVTERRS----SPLLRRKDGP-IPSAKK----RSLDVA----
----DSACNSAPGSGPSSPN---------NSSSNIPSENGIT--ISSSPGEASLLQRLAA--REGSVSHLSLYTSPSLPN
ITLG---LPATGPAASVVSGH-----------------------------------------------------------
-----------------KDGDSRLTLPALQQGIPLTSPFLPPTHLPS-----------YLTSSALDREAPGGGAAGAHNP
LLQHMVLLEQGHSPMVLTCLLF----------------------------GPFHNKSLGG--LPLQS-----PSVSKLAR
GHRPLGRTQSAPLPQ----QQCGQAQALQQLVVQQQ--HQQFLEKHKQQFQ-QQQHIISKIMSKP---------TDQVSA
VSSSPSGP--ARQHQSHPEETEEELREHQGLPSSSSPPTPSSLPVKEAG-------------PMRSVVIKQEPVDPQE--
VEEKEQ----RERQAEKDFLFRQ-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLPVSFAGHRP
LSRAQSSPASAS---FPIVVP--ESTTKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT
---TIHPEHAGRIQSIWSRLQETGL-----------RAHCECIRGRKASLEELQTIHSEAHVLLYGTN--PL-RQKLDCK
ISLS----SVSPMFVRLPCGG---IG-VDSDTIWNEVHSSTAARLAVGSVAELVFKVASG--ELKNG-FAVVRPPGHHAE
ESAPMG-FCYFNSVAIAAKLLQQRLS----VRKILIVDWDVHHGNGTQQAFYADPGILYISLHRYDDGNFFPGS--GAPD
EVGSGAGVGFNVNMAFTGGLEPPMGDVEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVDGHASPLGGYKLTAKC--F
GYLTRQLMGLAGGRVV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPIPDKLMQQRPNANAVRS
MEKVLEAHG-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWCSLQRSASTLGCSLSEALQRD-----TEEAETVS-AMASLSVAN-KHM-------GK-RSEEE
PMEEETS----------------------------------------------------------------
>Tetraodon_nigroviridis-HDAC4(ENSTNIP_...
---------------------------------------------ECALSSTEGILGKEQPLEVLKTSVLNHIPTVDIN-
SALPLRLPPAA----------IPMDLRVDPQ------QQQQAGGGGGPSVCDQ-QLQQELLTLKQKQQIQRQILIAEFQR
QHEQLSRQHEAQLQEHIKQQQ----------ELLALKHQQELLE--HQRKMENH---------RMEQELEKQQREQK--L
QLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNQGGPHNDAP--YCKTQHSSLDQSSPPQT---GVS-
TYNQP-VLGVYNPRDDFPLRKTAS--EPNLKLRSRLKQKVSERRS----SPLLRRRDSP-ITTAKK----RSLDMA----
----DSACSSAPGSGPSSPN---------NSSNNIPSENGVAVSVSNNT-EVSLAQRMCTGAERGSANQLSLYTSPSLPN
ITLG---LPATATATAASNVT-----------------------------------------------------------
---------------------SAQTDGGLQPALSLSPPFLSGSHLTP-----------YLAEAGAGTGG-----HPAHSP
LLQHMVLMEQSPAQSPLVTGRS----------------------------FSNMQNDSSISGSSFGA-----ASMAKLQR
QHRPLGRTQSAPLPQGSAAQAHAQALALQQLVAMAT--ER----KPQPFMV-RQT--------------------LHIFQ
MMTKPSESPMGRQHQSHPEETEEELREHQDGGALPAG-----------------------------VTIKQEPPDPQELQ
EEALHRE---RERQAEQQELLFR-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSISFPGHRP
LSRAQSSPASASS--FPISVPASEPPTKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT
---NNHPEHAGRIQSIWSRLQETGL-----------RAQCECIRGRKATLEELQTVHSEAHVLLYGTN--PL-RQKLDC-
--------SITPMFVRLPCGG---IG-VDSDTIWNEVHSSSAARLAVGSVAELVFKVATR--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----INKILIVDWDVHHGNGTQQAFYDDPSVLYLSIHRYDDGNFFPGS--GAPD
EVGSGPGVGFNVNVAFTGGLEPPMGDAEYLAAF--RSVVMPIANEFAPDIVLVSS-GFDAVEGHPPPLGGYTLTAKC--F
GYLTRQLMTLAGGRLV-LALEGGHDLTAICDASEACLAALLGQEL----------------DPLPKSVLEQRPNANAVRS
LEKVLEIHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSVQRYSLHLGLSLLEAKRGD-----SEEAEAVS-AMASLSVANTNAI-------DQSRSEEE
PMEEEEPL---------------------------------------------------------------
>Tetraodon_nigroviridis-HDAC4(ENSTNIP_(2)
---------------------------------------------VGAQIHPDGVPVCREAPCLKLSQARLPHLAVDVST
AALPMQVPPAATA-------ILPMDLRVDHH------HNHQQQP---NHQEQ--QLQQELVALKHKQQLQRQLLIAEFQR
QHEQLSRQHEIQLQEHIKHQQ----------DLLALKHQQELLE--HQRKIEQQ---------RHEQELEKQQREYK--L
HQLKNKDRGQES---AIASTEVKMRLQEFVLNKKKALAQRN--LNHCLPT-DPRYWYGKTQHSSLDQSSPPQT---ALS-
AYTHP-MLGTYDAKDDFPLRKTAS--EPNLKLRSRLKQKVTERRS----SPLLRRKDGP-TTTAKK----RSLDMA----
----DSACNSAPGSGPSSPN---------NSSSNIPSENGVT--ISSSPAEASLLQRLVA--REGSVSHLSLYTSPSLPN
ITLG---LPATGPAASVVSGH-----------------------------------------------------------
-----------------QDGDGRLALPALQQGIPLTSPFLPHTHLPS-----------YLTPSPLDREGPGGAAAGSHNP
LLQHMVLLEQGHS--------------------------------------PVATPGLGG--LPLPS-----PSVSKLAR
GHRPLGRTQSAPLPQ----QQCGQAQALQQLVVQQQ--HQQFLEKHHQQDF-RQN-------------------AKQVSA
VSSSPSGP--ARQHQSHPEETEEELREHQGLSSSSS--SSPSVSVKEAG-------------PIRGVVIKQEPVDPQE--
LEEKEQ----RERQAEKDFLFRQ-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLPVSFAGHRP
LSRAQSSPASAS---FPIVVP--EPSTKLRFTT-----------------------------GLVYDSLMQKHQCMCGNT
---TVHPEHAGRIQSIWSRLQETGL-----------RAHCECIRGRKASLEELQTVHSEAHVLLYGTN--PL-RQKHDSR
LLKC----SVSPMFVMLPCGG---IG-VDSDTIWNEVHSSTAARLAVGSVAELVFKVASG--ELKNG-FAVVRPPGHHAE
ESAPMG-FCYFNSVAIAAKLLQQRLN----VRKILIVDWDVHHGNGTQQAFYADPGILYISLHRYDDGNFFPGS--GAPD
EVGSGPGAGFNVNMAFTGGLEPPMGDVEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVDGHASPLGGYKLTAKC--F
GYLTRQLMALAEGRLV-LALEGGHDLTAICDASEACVSALLGNEL----------------EPIPDEVMRQRPNANAVRS
MEKVVGAHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSLQRSASTLACSLSERLQRD-----TEEAETVS-AMASLSVAN-KHM-------GK-RCEEE
PMEEEAS----------------------------------------------------------------
>Gasterosteus_aculeatus-HDAC4(ENSGACP_...
--------------------------------------------------------------------------SVDVSS
AALPMQVPPTTTA-------ILPMDLRVVTG------GAEALTCRS-RPTDQP-ELQQELVTLKHKQQLQRQLLIAEFQR
QHEQLSRQHEVQLQEHVKHQQ----------DLLALKHQQELLE--HQRKMEQQ---------HLEQEMEKQQREHK--L
LQLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNHRLPS-DPRFWYGKTQHSSLDQSSPPQT---ALS-
AYTHP-MLGTYDSKDDFPLRKTAS--EPNLKLRSRLKQKVTERRS----SPLLRRKDGP-ITTAKK----RSLDVA----
----ESACNSAPGSGPSSPN---------NSSSNIPCENGVN--ISCSPGEASLLQRLAA--REGSVSQLSLYTSPSLPN
ITLG---LPATGQASSVGSVH-----------------------------------------------------------
-----------------QDGESRLALPALQQGIPLTRPFLPTAHLPS-----------YLASSALDREGGGGGVAG-HNP
LLQHMVLMEQSHNSMG-------------------------------------LFFGLAG--LPLPS-----PSVSKLAR
GHRPLGRTQSAPLPQ----QQCGQAQALQQLVVQQQ--HQQFLEKHKQQFQ-QQQ--------------------HIINK
ASSSASGP--ARQHQSHPEETEEELREHQGLSLSSLS-ASCSASAQDTG-------------PLRGLVIKQEPSDPQEQQ
QEEREK----MERLVEQDFLFRQ-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSVSFAGHRP
LSRAQSSPASAS---FPMVVQ--EPPTKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT
---TSHPEHAGRIQSIWSRLQETGL-----------RSHCECIRGRKASLEELQTVHSEAHVLLYGTN--PL-RQKLD--
---C----SVSPMFVRLPCGG---IG-VDNDTIWNEVHSSSAARLAVGSVVELVFKVASG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLN----VSKVLIVDWDVHHGNGTQQAFYADPNVLYLSLHRYDDGNFFPGS--GAPD
EVGSGAGVGFNVNMAFTGGLEPPMSDAEYLAAF--RTVVMPIANEFAPDVVLVSS-GFDAVDGHAPPLGGYKLTAKC--F
GYLTRQLMGLAGGRLV-LALEGGHDLTAICDASEACVSSLLGNEL----------------DPIPEEVLQQIPNANAVRS
MEKVLEIHN-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWRSLQRSASTLGCSLSEALRRD-----AEEAETVS-AMASLSVAN-KLV-------GK-RAEEE
PMEEEATM---------------------------------------------------------------
>Gasterosteus_aculeatus-HDAC4(ENSGACP_(2)
---------------------------------------------CGVILYPCAVNQKQSPTLCLPPPHL----AVDIN-
SALPLRLPPAA----------IPMDLRVGPR------SPRPVSSR---PGRVW-KIAASIIGATDQQQPTTNMIEVSLRQ
KFERIAGSLETLLWCFFPQQQQ---------ELLALKHQQELLE--HQRKMENH---------RLEQELEKQQREQK--L
LLLKNKERGQES---AVASTEVKMRLQEFVLNKKKALAQRS--LNQGGLHNDAPYWYRKTQHSSLDQSSPPQT---GVS-
TYNHP-VLGVYNPRDDFPLRKTAS--EPNLKLRSRLKQKVSERRS----SPLLRRRDSP-ITSAKK----RSLDMA----
----DSACSSAPGSGPSSPN---------NSSNNIPNENGITASVANNT-EASLAQRLCG-AERGSVNQLSLYTSPSLPN
ITLG---LPATATSTAASNQ------------------------------------------------------------
-------------------------EGGLQPALSLSPPFLSGGHLTP-----------YLAEAGAGTGG-----HGAHSP
LLQHMVLMEQSPAQSPLVTGSL----------------------------PVFMSKGVSG-LSMSPA-----ASMAKLQR
QHRPLGRTQSAPLPQGSAAQAHAQALALQQ---------------------------------------------LHLNK
MMTKPGESPGGRQHQSHPEETEEELREHQDGGALPPG-----------------------------VTIKQEPPDPQELQ
EEALQQH---RERQAEQ-ELLFR-----QQALLLEQQRIHQLRNYQ-----------------ASMEAAGLSLSFPAHRP
LSRAQSSPASASS--FPISVPPPDPSAKPRFTT-----------------------------GLVYDSLMQKHQCMCGNT
---NSHPEHAGRIQSIWSRLQETGL-----------RAQCECIRGRKASLEELQTVHSEAHVLLYGTN--PL-RQKLDCK
---C----SVTPMFVRLPCGG---LG-VDSDTIWNEVHSSSAARLAVGSVVELVFKVATG--ELKNG-FAVVRPPGHHAE
ESTPMG-FCYFNSVAIAAKLLQQRLS----VNKILIVDWDVHHGNGTQQAFYDDPNVLYLSIHRYDDGNFFPGS--GAPD
EVGSGPGVGFNVNVAFTGGLDPPMGDVEYLAAFRLRSVVMPIANEYCPGTSCWSPPGLDGVEGHPP-LSGYTLTSKC--F
GYLTRQLMTLAGSRVV-LALEGGHDLTAICDASEACVAALLGQEL----------------DPLPKAVLEQRPNPNAVRS
LEKVLETHS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KYWGSLHRCSPLLGLSLLEAKRGD-----SEEAEAVS-AMASLSVANCNAM-------DQ-RPEEE
PMEEEEPL---------------------------------------------------------------
>Homo_sapiens-HDAC5(ENSP_337290)
-------------------------------------------MNSPNE-SDGMSGREPSLE-ILPRTSLHSIPVTVEVK
PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALKQQQQLQKQLLFAEFQK
QHDHLTRQHEVQLQKHLKQQQEMLAAK-QQQEMLAAKRQQELEQ---QRQREQQ----------RQEELEKQRLEQQ--L
LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP
SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP
--GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN
ISLG---LQATVTVTNSHLTASPK--------------------------------------------------------
--------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS
LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP
RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K
ILTKTGELP--RQPTTHPEETEEELTEQQEVL-LGEGALTMPREG-----------------STESESTQEDLEEEDEED
DGEEEE---DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA
LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTT-----------------------------------------------
--------------------------------------------------------------------------------
---G---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE
ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE
EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F
GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT
LEKVIEIQS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE
PMEQEPAL---------------------------------------------------------------
>Macaca_mulatta-HDAC5(ENSMMUP_8946)
-------------------------------------------MNSPNE-SDGMSGREPSLE-ILPRTSLHSIPVTVEVK
PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALKQQQQLQKQLLFAEFQK
QHDHLTRQHEVQLQKHLKQQQEMLAAK-QQQEMLAAKRQQELEQ---QRQREQQ----------RQEELEKQRLEQQ--L
LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP
SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP
--GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN
ISLG---LQATVTVTNSHLTASPK--------------------------------------------------------
--------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS
LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP
RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K
ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGEGALTMPREG-----------------STESESTQEDLEEEEEEE
DGEEEE---DCIQVKDEEGESGAEEGPDSEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA
LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTT-----------------------------------------------
--------------------------------------------------------------------------------
---G---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE
ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE
EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F
GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT
LEKVIEIQS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE
PMEQEPAL---------------------------------------------------------------
>Pan_troglodytes-HDAC5(ENSPTRP_15756)
RHGGPGLPSRPSVCYRLSLLTSPQLHPLPSQPPTPASCRPRAGMNSPNESADGMSGREPSLE-ILPRTSLHSIPVTVEVK
PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALKQQQQLQKQLLFAEFQK
QHDHLTRQHEVQLQKHLKQQQEMLAAK-QQQEMLAAKRQQELEQ---QRQREQQ----------RQEELEKQRLEQQ--L
LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP
SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP
--GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN
ISLG---LQATVTVTNSHLTASPK--------------------------------------------------------
--------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS
LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP
RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K
ILTKTGELP--RQPTTHPEETEEELTEQQEVL-LGEGALTMPREG-----------------STESESTQEDLEEEDEEE
DGEEEE---DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA
LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTTG----------------------------VVYDTF-MLKHQCMCGNT
---HVHPEHAGRIQSIWSRLQETGL-----------LSKCERIRGRKATLDEIQTVHSEYHTLLYGTS--PLNRQKLDSK
KLLG---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE
ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE
EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F
GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT
LEKVIEIQS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE
PMEQEPAL---------------------------------------------------------------
>Gorilla_gorilla-HDAC5(ENSGGOP_19129)
----------------------------------------------SPLNAGGWSGERPAYEPVLPKTRVLSLLPAVEVK
PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTL-----------------------LFAEFQK
QHDHLTRQHEVQLQKHLK-----------PPRPPTPARAWLTCA---SVPMPLQ----------QQQEML?QEMLAA--L
LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP
SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP
--GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN
ISLG---LQATVTVTNSHLTASPK--------------------------------------------------------
--------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS
LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP
RHRPLSRTQSSPLPQS--------PQARQVLFSEEL--PRLFLTHIEALPGRREGG-----------------------K
ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGEGALTMPREG-----------------STESESTQEDH-------
----------CIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPL---------------QPLQVYQAPLSLATVPHQA
LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTTG----------------------------EPPPTVRKLPQAGLWGDT
---DVP--EGGPVSPVESKTQGFGR-----------RGKAEGAVRR-VQLRRHSWQRSDSCECPGGVK----RGQRLEIL
FRAG---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE
ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE
EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F
GHLTRQLMTLAGGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT
LEKVIEIQS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQA-QAAAAREHSPRPAEE
PMEQEPAL---------------------------------------------------------------
>Callithrix_jacchus-HDAC5(ENSCJAP_18977)
--------------------------------------------TESCFSADGMSGREPSLE-ILPRTSLHSIPVTVEVK
PVLPGAMPSSMGGGGGG--SHSPVELRG------------ALVGSVDPTL-----------------------LFAEFQK
QHDHLTRQHEVQLQKHLK-----------QQQE-------MLAA---KQQQEML----------AAEELEKQRLEQQ--L
LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP
SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP
--GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN
ISLG---LQATVTVTNSHLTASPK--------------------------------------------------------
--------------LSTQQEAERQALQSLRQGGMLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS
LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP
RHRPLSRTQSSPLPQS--------PQARQALLSEEP--PGLFLTHVEALPGRSEGG-----------------------K
ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGEGALTMPREG-----------------STESESTQEDH-------
----------CIQVKDEEGESGAEEGPNSEEPSAGYKKLFSDAQQL---------------QPLQVYQAPLSLATVPHQA
LGRTQSSPAAPGG--MKSPP-DQP--VKHLFTTG----------------------------VVYDTF-MLKHQCMCGNT
---HVHPEHAGRIQSIWSRLQETGL-----------LSKCERIRGRKATLEEIQAVHSEYHTLLYGTS--PLNRQKLDSK
KLLG---PISQKMYAVLPCGG----IGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG--ELKNG-FAIIRPPGHHAE
ESTAMG-FCFFNSVAITAKLLQQKLN----VGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGS--GAPE
EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAF--RTVVMPIAHEFSPDVVLVSA-GFDAVEGHLSPLGGYSVTARC--F
GHLTRQLMTLAEGRVV-LALEGGHDLTAICDASEACVSALLSVEL----------------QPLDEAVLQQKPNINAVAT
LEKVIEIQS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KHWSCVQKFAAGLGRSLREAQAGE-----TEEAETVS-AMALLSVGAEQV-QAAAAREHSPRPAEE
PMEQEPAL---------------------------------------------------------------
>Pongo_pygmaeus-HDAC5(ENSPPYP_9379)
-------------------------------------------MNSPNESADGMSGREPSLE-ILPRTSLHSIPVTVEVK
PVLPRAMPSSMGGGGGG--SPSPVELRG------------ALVGSVDPTLREQ-QLQQELLALK-HQQLQKQLLFAEFQK
QHDHLR-QHEVQLQKHLQQQ-----------EMLAAKRQQELEQ---QRQREQQ----------RQEELENLRLEQQ--L
LILRNKEKSKES---AIASTEVKLRLQEFLLSKSKE-PTPG-GLNHSLPQ-HPKCW--GAHHASLDQSSPPQSGPPGTPP
SYKLP-LPGPYDSRDDFPLRKTAS--EPNLKVRSRLKQKVAERRS----SPLLRRKDGTVISTFKK----RAVEITGAGP
--GASSVCNSAPGSGPSSP----------NSSHSTIAENGFTGSVP-NIPTE-MLPQHRALPLDSSPNQFSLYTSPSLPN
ISLG---LQATVTVTNSHLTASPK--------------------------------------------------------
--------------LSTQQEAERQALQSLRQGGTLTGKFMSTSSIP----------GCLLGVALEGDG-----SPHGHAS
LLQHVLLLEQARQQSTLIA----------------------------------VPLHGQSPLVTGER-VATSMRTVGKLP
RHRPLSRTQSSPLPQS--------PQALQQLVMQQQ--HQQFLEKQKQQ--QLQLG-----------------------K
ILTKTGELP--RQPTTHPEETEEELTEQQEAL-LGE