>Homo sapiens ERBB4
----------------------------------------------MKPATGLWVWVSLLVAAGTVQPSDSQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEH-NRDLSFLR-------------------------------------------------------------------SVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR----------KDGNFGLQELGLKNLT-----------------------------------------------------------EILNGGVYVDQNKFLCYAD--TIHWQDIVRNP-----WPSNLTLVSTNGSSGCGRCHKSCT-------GRCWGPTENHCQTLTRTVCAEQCDG--RCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHN-FVVDSSSCVRACPSSKME-----VEENGIKMCKPCTD-ICP--KACDGIGTGS-----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAI--------EAIDPEKLNVFRTVREITG-----FLNIQSWPPNMTDFSVFSNLVTIGGRVLY--SGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTIN------QRIVIRDNRKAENCTAEG-MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQ-------------------------------------------------------------GANSFIFKYAD------------------------------------------------------------PDRECHPCHPNCTQGCNGPTSHDCIYYP------------------------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETE-LVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHK--DNIGSQLLLNWCVQIAKGMM--------------YLEERRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHVKITDFGLARLLEGDEKEYNADGG---KMPIKWMA---LECIHYRKFTHQSDVWSYG-------VTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKC-------------WMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN------DSKFFQNLLDEED--LEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRSEIGHSPP---------------------PAYTPMSGNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKPVAPH-VQEDSSTQRYSADPTVFAPERSPRGELDEEGYMTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDN----------PEYHNASNGPPKAEDEYVNEPLYLNTFA------------------NTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYS---------------------------------------------TKYFYKQNGRIRPIVAE-----------------NPEYLSEFSLKPGTVLPPPPYRHRNTVV
>Mus musculus ERBB4
----------------------------------------------MKLATGLWVWGSLLMAAGTVQPSASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEH-NRDLSFLR-------------------------------------------------------------------SIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR----------KDGNFGLQELGLKNLT-----------------------------------------------------------EILNGGVYVDQNKFLCYAD--TIHWQDIVRNP-----WPSNMTLVSTNGSSGCGRCHKSCT-------GRCWGPTENHCQTLTRTVCAEQCDG--RCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHN-FVVDSSSCVRACPSSKME-----VEENGIKMCKPCTD-ICP--KACDGIGTGS-----LMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAI--------DAIDPEKLNVFRTVREITG-----FLNIQSWPPNMTDFSVFSNLVTIGGRVLY--SGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTIN------QRIVIRDNRRAENCTAEG-MVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQ-------------------------------------------------------------GANSFIFKYAD------------------------------------------------------------QDRECHPCHPNCTQGCNGPTSHDCIYYP------------------------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETE-LVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLDYVHEHK--DNIGSQLLLNWCVQIAKGMM--------------YLEERRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHVKITDFGLARLLEGDEKEYNADGG---KMPIKWMA---LECIHYRKFTHQSDVWSYG-------VTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKC-------------WMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN------DSKFFQNLLDEED--LEDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNR-------------------------------------NQFVYQDGGFATQQGMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKPVAPH-VQEDSSTQRYSADPTVFAPERNPRGELDEEGYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQALDN----------PEYHSASSGPPKAEDEYVNEPLYLNTFA------------------NALGSAEYMKNSVLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYS---------------------------------------------TKYFYKQNGRIRPIVAE-----------------NPEYLSEFSLKPGTMLPPPPYRHRNTVV
>Rattus norvegicus ERBB4
----------------------------------------------MKLATGLWVWGSLLVAARTVQPSASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEH-NRDLSFLR-------------------------------------------------------------------SIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYR----------KDGNFGLQELGLKNLT-----------------------------------------------------------EILNGGVYVDQNKFLCYAD--TIHWQDIVRNP-----WPSNMTLVSTIGSSGCGRCHKSCT-------GRCWGPTENHCQTLTRTVCAEQCDG--RCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHN-FVVDSSSCVRACPSSKME-----VEENGIKMCKPCTD-ICP--KACDGIGTGS-----LMSAQTWWTSFQYKYCLCYKIIVLNLAASLLDFSDPYNAI--------DAIDPEKLNVFRTVREITG-----FLNIQSWPPNMTDFSVFSNLVTIGGRVLY--SGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTVN------QRIVIRDNRRAENCTAEG-MVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDGEFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQ-------------------------------------------------------------GANSFIFKYAD------------------------------------------------------------QDRECHPCHPNCTQGCNGPTSHDCIYYP------------------------------------------------WTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETE-LVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANVEFMDEALIMASVDHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHK--DNIGSQLLLNWCVQIAKGMM--------------YLEERRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHVKITDFGLARLLEGDEKEYNADGG---KMPIKWMA---LECIHYRKFTHQSDVWSYG-------VTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKC-------------WMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN------DSKFFQNLLDEED--LEDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIGHSPP---------------------PAYTPMSGNQFVYQDGGFATQQGMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKPVVPH-VQEDSSTQRYSADPTVFAPERNPRAELDEEGYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQALDN----------PEYHSASSGPPKAEDEYVNEPLYLNTFT------------------NALGNAEYMKNSLLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYS---------------------------------------------TKYFYKQNGRIRPIVAE-----------------NPEYLSEFSLKPGTMLPPPPYRHRNTVV
>Xenopus tropicalis ERBB4
-------------------------------------------------------------------PLFSIAVCAGTENKLSSLSDLEQQYKALRKYYENCEVVMGNLEITSIEP-GRNLSFLR-------------------------------------------------------------------SIREVTGYVLVALNQFDYLPLENLRIIRGIKLYEDRYALAIFLNYR----------KDGNYGLRELGLRNLT-----------------------------------------------------------GIISIFSILDKKKNILVLK--NMYWEKKIRNISK---WPPKCVHFSSFCENGGGRCPKSCM-------GRCWGPSDQHCQRLTKTVCAEQCDG--RCYGSYVSDCCHRECAGGCTGPKDTDCFSCMKFNDSGSCVTQCPQPNIYNPTAFQLEQNPKAKYTYGAFCVNKCPHN-FVVDDSSCVRACPSNKME-----VEENGIKMCKPCAG-ICP--KVCDGIGTGS-----LQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNI--------AALEPQKLNIFFTVREITG-----FLNIQSWPRNMTDLSVFSNLVNIGGRVLY--SGISLLILKQQSLNSLQFQSLKEISAGNVYITDNRNLCYYHTVNWTSLFRTSN------QRTTIRENKKPENCTAEG-MVCDPLCSNAGCWGPGANQCLSCRYFSRGKSCVRSCNLYKGESREFVNGSVCVMCDSQCEKMEDSIVTCYGPGPDHCTKCSNFKDGPNCVEKCPEGLQ-------------------------------------------------------------GANSFIFKYAD------------------------------------------------------------EDKECHPCHPNCTDGCNNPTSHDCL---------------------------------------------------WNDPLTLPQHARTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLETE-LVEPLTPSGTAPNQAQLRILKETELKRIKILGSGAFGTVYKGIWVPE-GETVKIPVAIKILNETTGPKANAEFMDEALIMASMDHPHLVRLLGVSLSPT-IQLVTQLMPHGCLLDYVHEHK--DNIGSQLLLNWCVQIAKGMM--------------YLEERRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHVKITDFGLARLLEGDEKEYNADGG---KMPIKWMA---LECIHYRKFTHQSDVWSYG-------VTVWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPVCTIDVYMVMVKC-------------WMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN------DSKFFQNLLDEED--LGDMMDAEEYLVPQAFNIPPPIYTSRTRIDSNRSEIGHSPP---------------------PAYTPMSGNQFVYRDGGYTTQEAVNLPFRPTACPITELSTAQGATAEVFDDVCCNGTLCKQVVSERIPEESSLQRYSADPTAFVPERNPRGVVGEDGYMTPMKEKPKSDYLNPVEENPFVSRRKNGDVQAVEK----------PEYNNGPSTQSKSEDEYVKERLYLNSFA------------------KPKENAEYLKNNGLTVPEKSKKAFDNPEYWNHSLPPRSTIHHPDYLHEYS---------------------------------------------TKYFYKQNGRIRPVVAE-----------------NPEYLTEFTLKPGTVLPPPPYRHRNTVV
>Tetraodon nigroviridis ERBB4
-------------------------------------------------------------------------VCPGTDNKLSSLSDLDQQYRTLKKLYENCEVVMGNLEITSIER-NRNLSFLKLPGQNQRRESSESGSFASCVPVLALTGWDQCQTEMRRIKLSLVLSVHLRLANAASVVPLTPVISHYQSIREVTGYVLVALNQFDYLPLENLRIIRGITLYEGRYSLAIFLNYR----------RDGYYGLRQLGLRNLTAGLLLSGSLKRSLKRRLSAYSCAIFMVISAKETPLISTCSPSPCDAATAPCSGLAFWPLEILHGGVLVDQNKFLCHAD--TIHWRDIIKNS-----LAELLVVSSNSSNPGCRRCHRSCN-------GRCWGHQEDQCQTLTKTVCAEQCDG--RCFGPYVSDCCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPRAKYTYGAFCVKKCPHN-FVVDHSSCVRACPSNKME-----VEKNRIKMCIPCTD-ICP--KVCDGIGTGS-----LLKNQTVDASNIDKFVNCTKINGNLIFLITGIKGDMYHGI--------GPLDPERLNVFRTVREITG-----YLNIQAWPENMTDLGVFSNLATIGGRSLYSISGISLLILKQRWISSFKFQSLDEISAGNVYISNNSGLCFYNTVNWTSLFRTSN------QKVLIRNNRDPKECSQLQ-MVCDGMCSEEGCWGSGPDQCLSCRYFKRGRSCVESCNLFEGDVPEFANGSVCLECDSQCERMDGNALTCLGQGPDQCVKCRHFKDGPNCVEKCPDGLQ-------------------------------------------------------------GANSFIFKYAK------------------------------------------------------------ANNECHPCHANCTQGCVGPRLQDCV----------------------------------------------------------GMMDRTPLIAAGIIGGLFIIVILALSVAVYARRKSIKKKRALRRFLETE-LVEPLTPSGTAPNQAQLRILKETELKRVKILGSGAFGTVYKGIWVPE-GETVKIPVAIKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLDYVHEHK--DNIGSQLLLNWCVQIAK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGDDTMENPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>Takifugu rubripes ERBB4
-------------------------------------------------------------------------VCAGTENKLSTLSDLDQQYQTMRKNYENCEVVMGNLEITSIDR-SRNLTFLR-------------------------------------------------------------------SIREVTGYVLVALNQFDYLPLENLRIIRGTKLYEDRYALAIFLNYR----------RDGNSGLRQLGLKNLT-----------------------------------------------------------EILNGGVYVDRNNFLCHAD--TIHWQDIVKHP-----RIHPLVVPTN-SSITCQKCHRSCN-------GRCWGPKVDQCQSLTKTVCAEQCDG--RCFGPYISDCCHRECAGGCYGPKDTDCFACTNFNDSGACVTQCPQPFFYNSITFQLEHNVRTKYTYGAFCVKKCPHN-FVVDHSSCVRACPSNKME-----VEENGIKICIPCTD-ICP--KACDGIGTAS-----LQTAQTVDSSNIDKFVNCTKINGNLVFLITGIKGDSYHNI--------EALDPEKLNVFRTVREITGESHERFLNIQSWPDNMTDLSVFSNLATIGGRTLY--SGISLLVLKQQGISSLQLQSLREISAGNVHVADNSQLCYYNTINWTRLFRTAH------QKALIRNNQSPEQCSKKR-MVCDPLCSGAGCWGPGPDQCLSCKYFSRGRTCVDGCNLYEGEIREYANESVCVECDGQCELADDDSLTCHGPGPEHCEKCLHFKDGPNCVEKCPDGLQ-------------------------------------------------------------GANSFIFKYAE------------------------------------------------------------ANNECHPCHANCTQG-------------------------------------------------------------------------TPLIAAGVIGVLFMVVILVLSVAVSVRRKNIKKKRALRRFLETE-LVEPLTPSGTAPNQAQLRILKETELKRVKVLGSGAFGTVYKGIWVPE-GEKVKIPVAVKILNEATGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLDYVHEHK--DNIGSQLLLNWCVQIAKGMM--------------YLEERRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHIKITDFGLARLLDVNEKEYNADGG---KMAIKWMA---LECIHYRKFTHQSDVWSYG-------VTIWELMTFGGKPYDGISTRDIPDLLEKGERLPQPPICTIDVYMVMVKC-------------WMIDADSRPKFKELAAEFTRMARDPQRYLVIQGDDCMKLPGPN------DSKFFQSLLAEEE--LEDLMDAEEYLVPHSFNIPPLAYTPRTRMDSNK----------------------------------------------------VFFFHIPCFINTLQILKTSGYLNLCGSHAGMASKVPLFAFQKGGGDDSSGQRYSADPTGLLSERGAKG--DQDGYMAAMRDKKISDYLNPVEENPFVTRRRNGDAHAVMDGAGCHTLHIAAAAAAPKNQHIHGDDEYINEPLYLNTFL------------------NPGDKNGLTASN--TIMKNKKANFDNPEYWQHSLPPKSSLHNPEYLQDCS---------------------------------------------TRFFYRQNGRIRPAVAE-----------------NQEYLSEAAMKAGNVLPPPPYRQRNTVV
>Danio rerio ERBB4
-------------------------------------------------------------------------VCPGTDNKLSTLSDLDQQYKTLRKFYENCEVVMGNLEITSIER-NRNLSFLK-------------------------------------------------------------------SIREVTGYVLVALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYR----------RDGYFGLRQLGLKNLT-----------------------------------------------------------EILNGGVYVDQNKFLCHAD--TIHWHDIIKNP-----RSELLVVPSNNSGNTCRRCHRSCN-------GRCWGHQEDQCQSLTKTVCAEQCDG--RCFGPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHN-FVVDHSSCVRACPSNKME-----VEENQTKMCIPCTD-ICP--KVCDGIGTGS-----LQMAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMFHGI--------RALDPDRLNVFRTVREITG-----FLNVQSWPENMTDLGVFSNLATIGGRSLY--SGISLLILKQRWITSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTST------QRALIKNNREPRECSKEQ-KICDPLCSEAGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQ-------------------------------------------------------------GANSFIFKYAE------------------------------------------------------------TNNECHPCHPNCTQGCTGPRIQDCV----------------------------------------------------------GILDRTPLIAAGLIGGLFVIVIIALGVAVYIRRKSIKKKRALRRFLETEQLVEPLTPSGAAPNQAQLRILKETELKRVKILGAGAFGMVYKGIWVPE-GETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPT-IQLVTQLMPHGCLLDYVHEHQ--DNIGSQLLLNWCVQIAKLIK--------------YKAHVKVI--------------------------------------------------------------ISAR-------------------------------------AVFFKVLKHLQCYTFCNKKILKIQLYYYYKLIV---KIPLKKCC---LYAVYY----------YSG-------VTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKC-------------WMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPN------HSTFFKSLLDEEE--LDDLMDADEYLVPQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>Homo sapiens ERBB3
----------------------------------------------MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVMGNLEIVLTGH-NADLSFLQ-------------------------------------------------------------------WIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVMLNYN----------TNSSHALRQLRLTQLT-----------------------------------------------------------EILSGGVYIEKNDKLCHMD--TIDWRDIVRDRD----AEIVVKDNGRS----CPPCHEVCKGR-------CWGPGSEDCQTLTKTICAPQCNG--HCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHN-FVVDQTSCVRACPPDKME-----VDKNGLKMCEPCGG-LCP--KACEGTGSGS-------RFQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKI--------PALDPEKLNVFRTVREITG-----YLNIQSWPPHMHNFSVFSNLTTIGGRSLYN-RGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRG-----PTEERLDIKHNRPRRDCVAEG-KVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAHEAECFSCHPECQPMEGT-ATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVL------------------------------------------------------------GAK-GPIYKYPD------------------------------------------------------------VQNECRPCHENCTQGCKGPELQDCLGQ---------------------------------------------------TLVLIG--KTHLTMALTVIAGLVVIFMMLGGTFLYWRGRRIQNKRAMRRYLERGESIEPLDP-SEKANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSS-LQLVTQYLPLGSLLDHVRQHR--GALGPQLLLNWGVQIAKGMY--------------YLEEHGMV-----------------------------------------------------------HRNLAAR-------------------------------------NVLLKSPSQVQVADFGVADLLPPDDKQLLYSEA---KTPIKWMA---LESIHFGKYTHQSDVWSYG-------VTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKC-------------WMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGP-EPHGLTNKKLEEVELEPELDLDLDLEAEEDNLATTTLGSALSLPVGTLNRPRGSQSLLSPS--SGYMPMNQGNLG-ESCQESAVSG-SSERCPRPVSLHPMPR-----GCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLE-EEDVNGYVMPDTHLKGTP-----SSREGTLSSVG----LSSVLGT--------------EEEDEDEEYEYMNRRRRHSPPH-----------PPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDYEYMNRQRD---------GGGPGGDYAAMGACPASE-QGYEEMRAFQGPGHQAPHVHYARLKTLRSLEAT------------DSAFDNPDYWHSRLFPKANAQRT----------
>Mus musculus ERBB3
----------------------------------------------MSAIGTLQVLGFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGH-NADLSFLQ-------------------------------------------------------------------WIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYN----------TNSSHALRQLRFTQLT-----------------------------------------------------------EILLGGVYIEKNDKLCHMD--TIDWRDIVRVPD----AEIVVKNNGGNSSQSGPPCHEVCKGR-------CWGPGPEDCQILTKTICAPQCNG--RCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHN-FVVDQTFCVRACPADKME-----VDKNGLKMCEPCRG-LCP--KACEGTGSGS-------RYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKI--------PALDPEKLNVFRTVREITG-----YLNIQSWPPHMHNFSVFSNLTTIGGRSLYN-RGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRG-----PAEERLDIKYNRPLGECVAEG-KVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGT-STCNGSGSDACARCAHFRDGPHCVNSCPHGIL------------------------------------------------------------GAK-GPIYKYPD------------------------------------------------------------AQNECRPCHENCTQGCKGPELQDCLGQ---------------------------------------------------AEVLMS--KPHLVIAVT--VGLTVIFLILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDP-SEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSS-LQLVTQYLPLGSLLDHVRQHR--ETLGPQLLLNWGVQIAKGMY--------------YLEEHSMV-----------------------------------------------------------HRDLALR-------------------------------------NVMLKSPSQVQVADFGVADLLPPDDKQLLHSEA---KTPIKWMA---LESIHFGKYTHQSDVWSYG-------VTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKC-------------WMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGIPPAA-EPSALSTKELQDAELEPDLDLDLDVEVEEEGLATT-LGSALSLPTGTLTRPRGSQSLLSPS--SGYMPMNQSNLG-EACLDSAVLG-GREQFSRPISLHPIPR-----GRQTSESSEGHVTGSEAELQERVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLE-EEDGNGYVMPDTHLRGTS-----SSREGTLSSVG----LSSVLGT--------------EEEDEDEEYEYMNRKRRGSPAR-----------PPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRG---------AGGSGGDYAAMGACPAAE-QGYEEMRAFQGPGHQAPHVRYARLKTLRSLEAT------------DSAFDNPDYWHSRLFPKANAQRI----------
>Rattus norvegicus ERBB3
----------------------------------------------MRATGTLQVLCFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGH-NADLSFLQ-------------------------------------------------------------------WIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYN----------TNSSHALRQLKFTQLT-----------------------------------------------------------EILSGGVYIEKNDKLCHMD--TIDWRDIVRVRG----AEIVVKNNGAN----CPPCHEVCKGR-------CWGPGPDDCQILTKTICAPQCNG--RCFGPNPNQCCHDECAGGCSGPQDTDCFACRRFNDSGACVPRCPEPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHN-FVVDQTFCVRACPPDKME-----VDKHGLKMCEPCGG-LCP--KACEGTGSGS-------RYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKI--------PALDPEKLNVFRTVREITG-----YLNIQSWPPHMHNFSVFSNLTTIGGRSLYN-RGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRG-----PSEERLDIKYNRPLGECLAEG-KVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNFLQGEPREFVHEAQCFSCHPECLPMEGT-STCNGSGSDACARCAHFRDGPHCVNSCPHGIL------------------------------------------------------------GAK-GPIYKYPD------------------------------------------------------------AQNECRPCHENCTQGCNGPELQDCLGQ---------------------------------------------------AEVLMS--KPHLVIAVT--VGLAVILMILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDP-SEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPE-GESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSS-LQLVTQYLPLGSLLDHVKQHR--ETLGPQLLLNWGVQIAKGMY--------------YLEEHSMV-----------------------------------------------------------HRDLALR-------------------------------------NVMLKSPSQVQVADFGVADLLPPDDKQLLHSEA---KTPIKWMA---LESIHFGKYTHQSDVWSYG-------VTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKC-------------WMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGTPPAA-EPSVLTTKELQEAELEPELDLDLDLEAEEEGLATS-LGSALSLPTGTLTRPRGSQSLLSPS--SGYMPMNQSSLG-EACLDSAVLG-GREQFSRPISLHPIPR-----GRPASESSEGHVTGSEAELQEKVSVCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLE-EEDGNGYVMPDTHLRGAS-----SSREGTLSSVG----LSSVLGT--------------EEEDEDEEYEYMNRKRRGSPPR-----------PPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRG---------AGGAGGDYAAMGACPAAE-QGYEEMRAFQGPGHHAPHVRYARLKTLRSLEAT------------DSAFDNPDYWHSRLFPKANAQRT----------
>Xenopus tropicalis ERBB3
-------------------------------------------------------------------------VCSGTMNGLSVSGDSDYQLFTLKNMYSNCQIVMGNLEIVLIDN-KGDLSFLT-------------------------------------------------------------------SIREVTGYVLIAVNIFTYLPLENLRVIRGAHLYDKKYALYMSLNNQ----------INGSLGIEKLGFHKLT-----------------------------------------------------------EILAGGVHITKNDHLCFTD--TINWKDIVQDSK----AAIEIESNSKA----CKPCDQACDGN-------CWGPEKTDCQTLTKTVCAEQCNG--RCFGKNPTECCHDECAGGCTDSSNLKCFVCRHFNDSEACVPHCPQPLIYNKLTFQLEPNPDAKYQYGGSCVKSCPRN-FVVDQSSCVRACPSNKME-----VEKNGVKMCEPCSG-LCP--KACEGTLHGS-------TYQTVDSSNIDKFINCTKILGNLDFLTIGIDGDLWRNI--------TALDPKKLSVFKTVKEITG-----YLNIQSWPKSLTDFSVFSSLSTIGGRTLHT-RGFSLLVMKNSNVTSLGFRSLQEISAGKVYIAENQNLCYCDTVNWTSLFPT-----YPRQSTEIKGNRKKNKCVEEG-KVCDPLCSNNGCWGSGPDQCLSCRNYSRNGVCLQSCNFTEGDEREYAKAGVCLKCHEECQKMEGR-LSCNGSGPDGCVQCVNYRDGLHCVSQCPNGIL------------------------------------------------------------GKD-RPIFKYPD------------------------------------------------------------ANKDCQPCHENCTHGCTGPEIKHCTGI---------------------------------------------------AAPIISSNTPTVVVAAVVATFFVLCCCALLG-TLYWRGQKIRNKRAMRRYLERGECLDMLDP-SEKTNTVQARLFKDTELKKLKILGSGVFGTVHKGVWIPD-GESIKIPVCIKVILDRTGRQTFHAVTDHMLAIGSLDHTYIVRLLGICPGSQ-LQLVTAYLPMGSLLQHVRKNKDSGAIGPQLLLNWCVQIAKGMC--------------YLEEHRMV-----------------------------------------------------------HRNLSAR-------------------------------------NVLMKSVNQVQVSDYGVADLLYPDDKKFCYNEI---KTPVKWMA---LESIHFGKYTHQSDVWSYVP---QKGVTLWEMMTFGAEPYTGIRLSEVPDLLEKGERLSQPQICTIDVYMVMVKC-------------WMIDENIRPTFKELGNEFTRMARDPPRYLVVTRNSDALQSPLPGDPPPLSEKQVSDLESDVDTDLESEDMAMQPKTPTT-----LYASRQRIDYSR-SQSALSSI--AGYLPMNQSLCSSSSCYGLPLLGKGTMTSAEPIPRHGTRRREDSLGRTVSESSEGCCTSSDLETIEDNSYGGG-SLSHISRSRLDSAYRSQRESLLVGTP----------DDDSEYIMPGLSQSVTE-----ISRDGTLTSQGSRS-LTPCLVN--------------ATDEEDEEYEYMNKKK--------------------PSSKEKLEYEYMDIRGTGDASNECIAFSPAE-GDKEGDYEYGNKEDYEYMNEK----------------GKYTNMNLVANLP-QQLERPTVIPQTCHR-EALQKGYHQPLRALEAK------------DCAFDNPDYWHSRLFSKTDLQMT----------
>Takifugu rubripes ERBB3
-------------------------------------------------------------------------VCSGTQNGLSTTGTSEIQYNLTKKIYTNCEIVMGNLEITMMEH-SRDFSFLQ-------------------------------------------------------------------SIREVTGYILLAINEFSRLPLDNLRVIRGNVLYENQYALAIMINYR----------KDGEHGLQELGLTHLT-----------------------------------------------------------EILQGGVKIIKNRDLSYAP--KVNWLDIVKDGA----ANITIFGNGPE-----KPCHEACGDVP------CWGPGRNMCQIMTKTVCAPQCNF--RCFGRSPSECCHSECAGGCTGPLDTDCFACRRFNDSGSCVPQCPMALIYNKYTFRLEPNPNAKFQYGSICVAQCPPN-FLVDGTSCVSSCPADKTE-----VEKKGVKRCEPCEG-LCP--KACHGTGSG--------TRETVDALNIDSFINCTKIQGSLHFLVTGIEGDKYKNV--------PPLDPEKLKIFNTVRQITD-----ILSVQSWPTNMSDLSVFSNLQIIEGRKLY--NSYSLLVVKNPSLTSLGLRSLREINDGAVYITGNKRLCYHDTVNWTRLFNP---HLPSQQKIEIKDNRPRSECG--------------RLLGPG------------------------------AKPVYVLQEVQQRRDLCAG-LHVLRWGADECVECANLQDGPHCISSCPQGVM------------------------------------------------------------GGE-EIIFKYPN------------------------------------------------------------KQGRCEPCHANCTKGSA-----------------------------------------------------------------IRLQM-VTGIVVGVIALLFVSFAVFVLTVLYRRGLAIRRKRAMRRYMERGESFEPLDH-GEKGTKVHARILKPSELRTVKLLGNGVFGSVYKGIWIPE-GETVKLPVAIKVIHDRTGQKTFNKPTDHMIVLGSLDHMNIVRILGICPGDS-LQLISQLSSHGSLLEHVRNCK--NKLSPQRLLNWCVQIAKGMY--------------YLEENKVV-----------------------------------------------------------HRNLAAR-------------------------------------NVLLKNNYTAQVSDYGIADLLHRDDKKYFFNEA---KAPIKWMA---LESILFRKYTHQSDVWSYG-------VTVWEMMSYGAEPYNTMRPQDVSDLLEKGERLSQPQICTIDVYMVMVKC-------------WMVDENVRPTFKELANEFTRMARDPPRYLVIKDTDEHVQRSAD----VLDADDLDVLEVVDTEMMNQEKEDEECGLAPAPYYVPQNRTLSRLSKMDTYKVVLSSSNVAGYLPMTP---GVDN--VTVWASRSRLNS----------------GRTMSESSEGCGTVVDMERSEDVSLSGSLKRHR---NRQDSAYMSQRDSMSCGPPETPSPDME-EEDQNGYVLP--GDSPKRDTLLSTS-RGIPG--RIGKSHSSSLLN--------------DPD--DEEYEYMNKQACNSVSPRHNGHWMKMNKKRTSSTSSQMTACSVDTIPSMELRRSQTMSSYNS-DLEQPGSNDVKYEYMDIRSIDKEDKGKDN-----GQLYEYEDMDSITSAQPEDAAVYQNIQKEGDSAARQGPAQTPGFDAYVRVRAGVGLGEPAAVDRSFDNPNYWHSRMFLKPNAVPT----------
>Danio rerio ERBB3
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGYSLLVMKIPTLKSLGLRSLKRISDGGIYITGNTQLCYHHTVNWTRLFGSGPRALRRQKSLDIKENRPQEQC---------------RMLGSG------------------------------TRSVFVLQELQKRRNMCTR-LQLHVRGSDECKACAHLQDGPYCVSSCPEGVQ------------------------------------------------------------GENGLIIYKFPN------------------------------------------------------------RQNKCQPCHANCTLGSAH--------Y---------------------------------------------------GVNIVRYRLPVTAIVLSVIFCVLLAFSVFVLSVLYRRSLSIRRKRAMRRYLQSGESFEPLEP-GEKGVKVHARILRTSELKKIKLLGSGVFGTVHKGIWIPE-GDTVKIPVAIKTIQDRTGRQTFQEITDHMLAMGSLDHAYIVRILGICPGAS-LQLVTQLSPQGSLLDHIRQRR--DNLNPQRLLNWCVQIAKGMY--------------YLEEQRMV-----------------------------------------------------------HRNLAAR-------------------------------------NILLKSDLIVQIADYGIADLLYPDEKKYFFNEI---KTPIKWMA---LESILFRRYTHQSDVWSYG-------VTVWEMMSYGAEPYSAMRPQDVPDLLEKGERLSQPQICTIDVYMVMVKC-------------WMIDENVRPTFKELANEFTRMARDPHRYLVIKEEDRAPDSASD----ETHQNG-TEIDILGVALEDQDDEVLEDAID-APRYITPSRSFSRL-RIDSHRSSLTPSTTAGYLPMTP---GLESSVQTGWASRSRLDS----------------ACTVSESSEGRG-ALELEMNDDFSSVGSLRRVR---HREDSAYMSQRDSLS-GPPETTSTGTQGEEDQNEYVLPGFGESPEKETLLFTSSRSTLSQKRLSRGHSGDFLE--------------ANRGAGEEYEYMNNQTLSLSHIPGQLKEYNQRAPRNRSASFNPGGMYSNHKPSRPSKRSSIEGSESSGGLSQSSTDQRSHSDGDFLSSEAEYTDGDLEG-GGGEAYEYEDMDSLAAGG-ASGAEYQNLDGEDEERDEDWSGGPRSPGPYVQVHAGT-------NHNAFDNPDYWHSRSFHKTKAVRT----------
>Homo sapiens ERBB2
-------------------------------------------------MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPT-NASLSFLQ-------------------------------------------------------------------DIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVT-GASPGGLRELQLRSLT-----------------------------------------------------------EILKGGVLIQRNPQLCYQD--TILWKDIFHKN-----NQLALTLIDTNRSRACHPCSPMC------KGSRCWGESSEDCQSLTRTVCAGGCA---RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQE----VTAEDGTQRCEKCSK-PCA--RVCYGLGMEH-----LREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNT--------APLQPEQLQVFETLEEITG-----YLYISAWPDSLPDLSVFQNLQVIRGRILH--NGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPH------QALLHTANRPEDECVGEG-LACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGS-VTCFGPEADQCVACAHYKDPPFCVARCPSGVKP-----------------------------------------------------------DLSYMPIWKFPD------------------------------------------------------------EEGACQPCPINCTHSCVDLDDKGCPAE--------------------------------------------------------QRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVRENR--GRLGSQDLLNWCMQIAKGMS--------------YLEDVRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHVKITDFGLARLLDIDETEYHADGG---KVPIKWMA---LESILRRRFTHQSDVWSY-------GVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC-------------WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED-LGPASPL------DSTFYRSLLEDDD--MGDLVDAEEYLVPQQGFFCPDP-------------------------------------------------------------------APGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVN----------------QPDVRPQPPSPREGPLPA----------------------ARPAGATLERPK-TLS-----PGKNGVVKDVFAFG--GAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDP-----------------PERGAPPSTFKG--TPTAE-----------------NPEYLGLDVPV-----------------
>Mus musculus ERBB2
DCPPLGTRSPGAPLPRRPLPAPRLCLPSPRPAPAAWSSLSHGAGAAVIIMELAAWCRWGFLLALLSPGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPA-NASLSFLQ-------------------------------------------------------------------DIQEVQGYMLIAHNRVKHVPLQRLRIVRGTQLFEDKYALAVLDNRDPLDNVTTAAPGRTPEGLRELQLRSLT-----------------------------------------------------------EILKGGVLIRGNPQLCYQD--MVLWKDVLRKN-----NQLAPVDMDTNRSRACPPCAPTC------KDNHCWGESPEDCQILTGTICTSGCA---RCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQE----VTAEDGTQRCEKCSK-PCA--GVCYGLGMEH-----LRGARAITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGV--------APLKPEHLQVFETLEEITG-----YLYISAWPESFQDLSVFQNLRVIRGRILH--DGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPWDQLFRNPH------QALLHSGNRPEEACGLEG-LVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVRGKHCLPCHPECQPQNSS-ETCYGSEADQCEACAHYKDSSSCVARCPSGVKP-----------------------------------------------------------DLSYMPIWKYPD------------------------------------------------------------EEGICQPCPINCTHSCVDLDERGCPAE--------------------------------------------------------QRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAVPNQAQMRILKETELRKLKVLGSGAFGTVYKGIWIPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVREHR--GRLGSQDLLNWCVQIAKGMS--------------YLEEVRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHVKITDFGLARLLDIDETEYHADGG---KVPIKWMA---LESILRRRFTHQSDVWSY-------GVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC-------------WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED-LGPSSPM------DSTFYRSLLEDDD--MGELVDAEEYLVPQQGFFSPDP-------------------------------------------------------------------ALGTGSTAHRRHRSSSARSGGGELTLGLEPSEEEPPRSPLAPSEGAGSDVFDGDLAVGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVN----------------QPEVRPQSPLTPEGPPPP----------------------IRPAGATLERPK-TLS-----PGKNGVVKDVFAFG--GAVENPEYLAPRAGTASQPHPSPAFSPAFDNLYYWDQNS-----------------SEQGPPPSTFEG--TPTAE-----------------NPEYLGLDVPV-----------------
>Rattus norvegicus ERBB2
----------------------------------------------MIIMELAAWCRWGFLLALLPPGIAGTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYVPA-NASLSFLQ-------------------------------------------------------------------DIQEVQGYMLIAHNQVKRVPLQRLRIVRGTQLFEDKYALAVLDNRDPQDNVAASTPGRTPEGLRELQLRSLT-----------------------------------------------------------EILKGGVLIRGNPQLCYQD--MVLWKDVFRKN-----NQLAPVDIDTNRSRACPPCAPAC------KDNHCWGESPEDCQILTGTICTSGCA---RCKGRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMHNPEGRYTFGASCVTTCPYNYLSTEVGSCTLVCPPNNQE----VTAEDGTQRCEKCSK-PCA--RVCYGLGMEH-----LRGARAITSDNVQEFDGCKKIFGSLAFLPESFDGDPSSGI--------APLRPEQLQVFETLEEITG-----YLYISAWPDSLRDLSVFQNLRIIRGRILH--DGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNAHLCFVHTVPWDQLFRNPH------QALLHSGNRPEEDCAVSSGLVCNSLCAHGHCWGPGPTQCVNCSHFLRGQECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSS-ETCFGSEADQCAACAHYKDSSSCVARCPSGVKP-----------------------------------------------------------DLSYMPIWKYPD------------------------------------------------------------EEGICQPCPINCTHSCVDLDERGCPAE--------------------------------------------------------QRASPVTFIIATVVGVLLFLILVVVVGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTST-VQLVTQLMPYGCLLDHVREHR--GRLGSQDLLNWCVQIAKGMS--------------YLEDVRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPNHVKITDFGLARLLDIDETEYHADGG---KVPIKWMA---LESILRRRFTHQSDVWSY-------GVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC-------------WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNED-LGPSSPM------DSTFYRSLLEDDD--MGDLVDAEEYLVPQQGFFSPDP-------------------------------------------------------------------TPGTGSTAHRRHRSSSTRSGGGELTLGLEPSEEGPPRSPLAPSEGAGSDVFDGDLAMGVTKGLQSLSPHDLSPLQRYSEDPTLPLPPETDGYVAPLACSPQPEYVN----------------QSEVQPQPPLTPEGPLPP----------------------VRPAGATLERPK-TLS-----PGKNGVVKDVFAFG--GAVENPEYLVPREGTASPPHPSPAFSPAFDNLYYWDQNS-----------------SEQGPPPSNFEG--TPTAE-----------------NPEYLGLDVPV-----------------
>Xenopus tropicalis ERBB2
----------------------------------------------------WGLCALLLLLRGRAAEEVMGEVCTGTDMKLLHPFSQRNHYETLSTIYRDCQVIQGNLEITYLKE-DNDVSFLK-------------------------------------------------------------------DIKEVQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDP----------SGTAGLRELRMKNLT-----------------------------------------------------------EILKGGVIMENNTQLCFQD--TVLWADILSQS-----NSQRNEVVLGSSNRQCPTCSPGCGSLPSGKSGFCWGEGQEYCQILTSTICNSGCQ---RCKGNHSTHCCHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPYNYLATEVGSCTLFCPQDNQE----VIVGN-VQKCEKCDK-QCS--KVCYGLGRDF-----LRTTQAVNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPN--------SVLNAQSLEVFKTLEEITG-----YIYIESWPEELKSLNVFENLRVIHGRMLQ--NGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWASLFRNPR------QTILKTINKPQEACDQEG-QNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESCNVPLRYPREHVNGSQCVPCHPQCLPQNGT-LTCNGTEAHQCMECAHYLDGEDCVEQCPSGVK------------------------------------------------------------GNSFVPIWKYPD------------------------------------------------------------KDRICQLCNVNCSHSCNQLDERGCPIL--------------------------------------------------------PDNSQVYMVASIVISILIVITISTAIVLYIRRRKQLKKKHTMRRLLQD-ELVEPLTPSGAIPNQAQMRILKETELKKMMILGSGAFGTVYKGIWIPD-GENIKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTST-VQLVTQLMPYGCLLDYVRENK--DRIASRDLLNWCVQIAKGMT--------------YLEDVRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKSPSHVKITDFGLARLLDVDETEYHADGG---KVPIKWMA---LESILHRRFTHQSDVWSY-------GVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKC-------------WMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPM------TTQFYSALLQEVG--MDDLVDAEEYLVPQRGFFPSE------------------------------------------------------------------------DVTSEHRSRISSTR-----VTDMLTTFSPFPPQS--ATEMQAEQALLQETAPSGAALARTMSERSGGSGSDALSEGEYVFDPPQNEESGSPHRYTDDPLHSG----------------EDETDRRLHFPKHSPTPTSTHT------------------VYRQKSTLERQKSTLERQKAQQCKNGLVRELRSPPALSSLDNPDYLPPPGLILPN-----GFPQAFDNPYYWNHELNL--------------AKADGDPAQGHNGFTTPTAE-----------------NPEYLGLDETMIRPRDIT----------
>Tetraodon nigroviridis ERBB2
------------------------------------------------------------------PCPLSVAACMGTDMKLSLPSSLENHHEMLRLLYTGCQVVHGNLEITHLHG-TPDLSFLQ-------------------------------------------------------------------GIVEVQGYVLVAHVSVSLLPLDNLRIIRGSQLYNSSYALAVLDN------------TLDGRGLRTLHLRSLT-----------------------------------------------------------EILFGSVYVWGNPQLCFPDPQSINWRDILDQQ-----NT-DTRHRLQPRAQNCPNCSSQC------LTS-CWGEAAQDCQTLTRSNCASGCQ---RCKGFLPNDCCHKQCAAGCTGPKDSDCLACRHFNDSGVCKENCPPPTTYDPATFQSKPNPDRKFSFGATCVKTCPYNYLAMDV-ACTLNYPKPNPKDVVPQPCGNDTQKCEKCEG-DCP--KVCYGPGMDDHGAVDSSGSTMVTAANVGQFNKCTKIFGSLAFHSQSFSRDPVTNA--------SGLSPEQLSVFRNLEEITG-----YLYIEAWPQEWMNLNVFDNLKVIRGRMLY--KGVFSLAIQNLQITSLGLRSLRSISGGLVLLHNNSQLCYTSSLPWESIVHPTQG-----PHRIVSKNLDPQICEKQG-HVCHRLCKG-GCWGPGPGQCASCETFQRGTECVEHCDIYQGSVREYASESLCVACHPECQPLNGS-ASCHGPGAEHCVECRKFQDGDFCVDHCPSGVK-------------------------------------------------------------EDHQTVWKYSN------------------------------------------------------------ATGHCLPCNTNCTLSCTVKDERGCPVD--------------------------------------------------------TRAGLGTTIAAAVGGVVLFFILLGLLFFYLRRQKKLKRKETMARILQEHELVEPLAPSGASPNQAQMRILKETELKKLKVLGAGAFGTVYKGVWAPD-GENVKIPVAIKVLRENTSPKANKEILDPLRVPS----------AGDLLDLH-RAVVTQLMSYGCLLEYVRKNK--DHIGSQLLLNWCVQIAKVWNPEAGFVSHYVASLFFLSHLMLAGILWTQMWCVCVCVCVCVGNELPGGSSSGAQRSSSPQCPGKESKPREDHGLRSGPSAGYRRDGISRRRGEGEMEDICTEDLPLINDVQSFCSFLRCRSNGWPWSQFCKGSSLIRVMCGATVCFKSLNVTIITCSNSKMNQTPVKLLKNGISNSHLHSLQRDQTVCTSFT------GVTVWELMTFGAKPYDMIPARDIPEVLEGGERLPQPPICTIDVYMIMVKSRLADIWTFCLLAGWMIDPDYRPRFKDLVKEFTTMARDPPRYVVIQSRDQG-------------------------------LDVEPSAAGGPGSMY-------------------------------------------------------------------------SSLSTLSRSQYPTLPLGASAANGVWSPPYPMLARSP---SAGEQSDSVFLESPDDPSLPPASPNRYCRDPTYSNDNQGDL----ETDGPGFHLPQHSHHSLPR----------------QSHRNHVLPEYVNQEIQHPRPG------------------ILERPTTLPRKG---------SRADRRLPNGLSSG--HSVENPGYLIPFTARTPT-------SPAFDNPYYLDHLAKARTGAGASEVLDSEALEAGGAMPRHVNGFVTPTAE-----------------NPEYLGLADTLSGHT-------------
>Takifugu rubripes ERBB2
------------------------------------------------------------------------AACMGTDMKLSLPSSLENHYEMLRLLYTGCQVVHGNLEITHLHG-NPDLSFLQ-------------------------------------------------------------------GIVEVQGYVLVARVSVSLVPLDNLRIIRGSQLYNSSYALAALDN------------TLDGQGLRTLALRSLT-----------------------------------------------------------EILFGGVYIWGNPQLCFPDPQSINWRDILDEL-----NT-DTRYRLQPRALNCPNCSSQC------LTS-CWGETVQDCQTLTHSNCALGCQ---RCKGSLTNDCCHKQCSAGCTGPKDSDCLACRHFNDSGVCKENCPPPTIYDPTMFQSKPNPDRKFSFGATCVKTCPYNYLAMDV-ACTLNYPKPNQEVIITQPCGNDTQKCEKCEG-DCP--KACYGPGMDNSGVMDSHGNTMVNSSNVEQFNKCTKIFGSLAFYPQSFTRDPVTNA--------SGLSPQQLSVFRNLEEITG-----YLYIEAWPQEWMNLSVFDNLKVIRGRMLY--KGVFSLAIQHLQITSLGLRSLRSISGGLVLLHNNSQLCYTSSLPWENIVHPTQG-----PHRIVSKNQDPQICEKQG-RVCHPLCEG-GCWGPGPSQCASCRTFQRGSECVEQCDIYQGSVREYANESVCVACHPECQPLNSS-ASCHGPGAEHCAECRNFQDGDVCVAHCPSGAK-------------------------------------------------------------EDHQTVWKYSN------------------------------------------------------------ATGHCLPCNTNCTLSCTVMDERGCPVD--------------------------------------------------------TRTGLGTTIAAAVGGVVLFFILLGLLFFYLRRQKKLKRKETMRRILQEHELVEPLAPSGASPNQAQMRILKETELKKLKVLGAGAFGTVYKGVWAPD-GENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLTST-VQLVTQLMSYGCLLEYVRKNK--DRIGSQLLLNWCVQIAKGMS--------------YLEEVRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKNPNHVKITDFGLARLLDIDETEYHADGG---KVPIKWMA---LESILHRRFTHQSDVWSY-------GVTVWELMTFGAKPYDMIPAREIPEVLEGGERLPQPLICTIDVYMIMVKC-------------WMIDPEYRPRFKDLVKEFTAMARDPPRYVVIQNEEQ------------------------------------------------------------------------------------------------------------------------MSMSSPVDNQFFRMFLAEEGNN--------------------------LRELLDAEEYLVPQPN---------------------------HFP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>Danio rerio ERBB2
-----------------------------------------------MEADRSFGLAWVLLLLLGITAATGREVCLGTDMKLALPSSLENHYEMLRLLYTGCQVVHGNLEITHLQG-NPDLSFLQ-------------------------------------------------------------------EIVEVQGYVLIAHVSVRSLPLDNLRIIRGSQLYKSNYALAVHNNSNS---------SQAGLGLRELRLRSLT-----------------------------------------------------------EILLGGVYIWGNPQLCFP--RNINWEDTVSKV-----QN-KPLH-LQDIPKNCPRCSSAC------KSGGCWGEKDQDCQTLTSVNCSSGCS---RCKGPKPSDCCHVQCAAGCTGPKDSDCLACRHFNDSGTCKDSCPPPTIYDPITFQSKPNKDKKFSFGATCVKQCPHNYLAMEV-ACTMVCPKANKEVISVEPDGQETQKCEKCEG-ECP--KVCYGLGMGN-----LQGVSVVNSTNIGMFTGCEKIYGSLAFLSDSFKGNTDTNS--------SGLQPSDLEKLKTIEEITG-----YLYIDAWSENLLDLSVFENLKVIRGRMLY--KGVFSLGVQSLQIESLGLRSLRSVSGGLVLIHNNSRLCYTSSLPWTSLLHPTQG-----PNLISNNNKDQQTCVSEG-KICDPLCGDSGCWGPGPSQCVSCLNYKRGTECVELCNVLHGSVREFEDGFNCVPCHPECRPINGT-ASCTGPGPDQCTDCMHFQDGDVCVERCPSGVK-------------------------------------------------------------EEQHTVWKYSN------------------------------------------------------------ATGHCLPCETNCTVSCPLDD-RGCPIQ--------------------------------------------------------QKTGPGTTVAITVGGVLLFIILLALLVFYLRRQKHQKKKETIRRRLQEHELVEPLTPSGAMPNQAQMRILKETELKKLRVLGSGAFGTVFKGIWAPD-GENVRIPVAIKVLRENTSPKANKEILDEAYVMAGVASPYVCRLLGICLTST-VQLVTQLMPYGCLLDYVRENK--DRIGSQYLLSWCVQIAKGMS--------------YLEEVRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKNPNHVKITDFGLARLLDIDEKEYHADGG---KVPIKWMA---LESILHRKFTHQSDVWSY-------GVTVWELMTFGMKPYESFQARDIPELLEAGERLSQPCNCTKEVYMIMVKC-------------WQIDPDNRPRFKDLVDEFTTMARDPSRYVVIQNEDQMSLSSPV------DSEFFRILMAEEGGNVKEFLDAEEYLVPQPGSIFNTHGEMRA-------------------------------------NGPSRHHSHRSTDQMVEVDGLPNGRELYSSVSMIEQSQYPTLPVGATANGMWPGTQYPPLARSISHRSAGGQSDSVFLDGYVEDSCPPSSPCRYSKDPTMPNGTDGDL----ETDG---NMVFLS-HTLPR----------------GTHT---QPEYVNQDMAS------------------------ERPSTLPRKA---------SER-RFILNGLSTG--NSVENPEYLVPIGSITPT-------SPAFDNPYYHDIAAKAQAVARVAIN--------GGTNHRQPNGFMTPTAE-----------------NPEYLGLADTWSGHKEYT----------
>Homo sapiens EGFR
--------------------------------------------MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQR-NYDLSFLK-------------------------------------------------------------------TIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYD----------ANKT-GLKELPMRNLQ-----------------------------------------------------------EILHGAVRFSNNPALCNVE--SIQWRDIVSSD-----FLSNMSMDFQNHLGSCQKCDPSCP------NGSCWGAGEENCQKLTKIICAQQCSG--RCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYE-----MEEDGVRKCKKCEG-PCR--KVCNGIGIGE-----FKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHT--------PPLDPQELDILKTVKEITG-----FLLIQAWPENRTDLHAFENLEIIRGRTKQ--HGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSG------QKTKIISNRGENSCKATG-QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM------------------------------------------------------------GENNTLVWKYAD------------------------------------------------------------AGHVCHLCHPNCTYGCTGPGLEGCPT----------------------------------------------------------NGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPE-GEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPFGCLLDYVREHK--DNIGSQYLLNWCVQIAKGMN--------------YLEDRRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG---KVPIKWMA---LESILHRIYTHQSDVWSYG-------VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKC-------------WMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPT------DSNFYRALMDEED--MDDVVDADEYLIPQQGFFSSPS---------------------------------------------------------------------TSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQP--LNPAPSRD---PHYQD----------------PHSTAVGNPEYLNTVQPT------------------------CVNSTFDSPA---------------HW-AQKGSHQISLDNPDYQQD----------------------------------------------FFPKEAKPNGIFKGSTAE-----------------NAEYLRVAPQSSEFIGA-----------
>Mus musculus EGFR
--------------------------------------------MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQR-NYDLSFLK-------------------------------------------------------------------TIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYG----------TNRT-GLRELPMRNLQ-----------------------------------------------------------EILIGAVRFSNNPILCNMD--TIQWRDIVQNV-----FMSNMSMDLQSHPSSCPKCDPSCP------NGSCWGGGEENCQKLTKIICAQQCSH--RCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYE-----VEEDGIRKCKKCDG-PCR--KVCNGIGIGE-----FKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRT--------PPLDPRELEILKTVKEITG-----FLLIQAWPDNWTDLHAFENLEIIRGRTKQ--HGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPN------QKTKIMNNRAEKDCKAVN-HVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMN-ITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIM------------------------------------------------------------GENNTLVWKYAD------------------------------------------------------------ANNVCHLCHANCTYGCAGPGLQGCEVW--------------------------------------------------------PSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPE-GEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPYGCLLDYVREHK--DNIGSQYLLNWCVQIAKGMN--------------YLEDRRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG---KVPIKWMA---LESILHRIYTHQSDVWSYG-------VTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKC-------------WMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPT------DSNFYRALMDEED--MEDVVDADEYLIPQQGFFNSPS---------------------------------------------------------------------TSRTPLLSSLSATSNNSTVACINRNG--SCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQP--LHPAPGRD---LHYQN----------------PHSNAVGNPEYLNTAQPT------------------------CLSSGFNSPA---------------LW-IQKGSHQMSLDNPDYQQD----------------------------------------------FFPKETKPNGIFKGPTAE-----------------NAEYLRVAPPSSEFIGA-----------
>Rattus norvegicus EGFR
--------------------------------------------MRPSGTARTKLLLLLAALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQR-NYDLSFLK-------------------------------------------------------------------TIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAVLSNYG----------TNKT-GLRELPMRNLQ-----------------------------------------------------------EILIGAVRFSNNPILCNME--TIQWRDIVQDV-----FLSNMSMDVQRHLTGCPKCDPSCP------NGSCWGRGEENCQKLTKIICAQQCSR--RCRGRSPSDCCHNQCAAGCTGPRESDCLVCHRFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYE-----VEEDGVSKCKKCDG-PCR--KVCNGIGIGE-----FKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRT--------PPLDPRELEILKTVKEITG-----FLLIQAWPENWTDLHAFENLEIIRGRTKQ--HGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPN------QKTKIMNNRAEKDCKATN-HVCNPLCSSEGCWGPEPTDCVSCQNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQTMN-ITCTGRGPDNCIKCAHYVDGPHCVKTCPSGIM------------------------------------------------------------GENNTLVWKFAD------------------------------------------------------------ANNVCHLCHANCTYGCAGPGLKGCQQ---------------------------------------------------------PEGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPE-GEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTST-VQLITQLMPYGCLLDYVREHK--DNIGSQYLLNWCVQIAKGMN--------------YLEDRRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG---KVPIKWMA---LESILHRIYTHQSDVWSYG-------VTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKC-------------WMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPT------DSNFYRALMEEED--MEDVVDADEYLIPQQGFFNSPS---------------------------------------------------------------------TSRTPLLSSLSANSNSSAVACINRNG--SCRVKEDAFLQRYSSDPTSVLTEDNIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQP--LHPAPGRD---LHYQN----------------PHSNAVSNPEYLNTAQPT------------------------CLSSGFDSSA---------------LW-IQKGSHQMSLDNPDYQQD----------------------------------------------FFPKEAKPNGIFKGPTAE-----------------NAEYLRVAPPSSEFIGA-----------
>Xenopus tropicalis EGFR
-------------------------------------------------------------------------VCLGNNNRLNQLGNTDEHYASLKRMYDGCEIVLGNLEITYLDR-LNDTSFLR-------------------------------------------------------------------NIQEVGGYVLIAINSVRSIHLENLQIVRGNMLYKSTYALAIVSNES----------LNTTNALEELHMGRLT-----------------------------------------------------------EILNGGVLISKNRKLCYLN--TIQWNDIVHTD-----NPINKISVDKSFSPQCPKCDAESC------NGSCWGPGQGNCQKLTKLTCAQQCSG--RCRGPLPSDCCHSQCASGCTGPRENNCLACRKFRDGETCKEGCPQLQIYNPATYQMDLNPDGKYSFGASCVKKCPHNYVVTDHGSCVRTCNSDSQE-----VEENGIRICKKCDG-SCNKDKVCDGINMGK-----LKSVLSVNASNIDLFQNCTKVNGDVAILHVAGYGDPFTNT--------SKLDPAKLSVFKSVREITG-----SLLIQWWPDNYTDLSVFENLETIRGRTKQ--HGIYSLAIVKRSITSLGLRSLKEVSDGDVIIKTNKNLCFVNTINFTNIFRIPK------QFSVLGFLESE------G-NVCDPLCSEEGCWGPGPFQCVSCRKYMRGRECVENCNFLSGEPREYTEDGKCFACNAECLQLNET-QTCSGPGADECFKCGHNSDGPFCVKTCPAGIQ------------------------------------------------------------GENSTLIWKYPD------------------------------------------------------------ETGACQLCHPECKLGCVGHGLDGCPL-----------------------------------------------------------PWSSHSVAAGVVGGILGAVVIGLVAFFFIRRSRINRKRTLRRILQERELVEPVTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYQGLWIPE-GEGIKIPVAIKELREATSPKANKEILDEAYVMASVENPYVCRLLGICLTST-VQLITQLMPFGCLLDYVRDNK--DNIGSQHLLNWCVQIAKGMN--------------YLEERRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKGPQHVKITDFGLAKLLGADEKAYHAEGG---KVPIKWMA---LESILHRTYTHQSDVWSYG-------VTVWELMTFGLKPYDGIPASEISNILEKGERLPQPPICTIDVYMIMVKC-------------WMIDAESRPKFRELSAEFTKMARDPTRYLVIQGDDRMHLPSPV------ESKIHPALVQEG---LGDIVDAEEYLLPHQGFFTSPS---------------------------------------------------------------------NSRTPLLSTMGP------------------PVREDSFVQRYSTDPT-VILEDSID----AFSEYVNQMVPKPIVETQTNAVYQNLVPLGNTVSPKE---TLYQN----------------SHSNGLNNPEYLNTGHTL------------------------VPKTDF-----------------------------INLDNPDYQQD----------------------------------------------FFPKEPKTNGHFKIPAAQ-----------------NPEYLGLAPYLYTWAR------------
>Tetraodon nigroviridis EGFR
--------------------------------------------------------------------------CQGITNRLNRLSSTDDHYANMLKTYSNCTVVLENLEITHMEE-HRDLSFLR-------------------------------------------------------------------SIEEVGGYVLIALNTVSRIHLDNLRIIRGHSLYDNKFALKVISNYN----------KSTGLGTSELLLNSLT-----------------------------------------------------------EILKGGVKISS-KMLCNVD--TIQWNDIVNTE-----TKPAMELPEKSNNPQCQKCHSSCF------NGSCWAPGSQNCQQLTKLNCAQQCSR--RCNGPAPSNCCNEHCAAGCTGPRATDCLACRDFQDDGVCKDSCPGLIRYDPNLHQLVPNPHGKYNFGAKCVKTCPHNYVVTDHGACVRTCSGNTYE-----IEEGGIRKCAKCDG-LCP--KVCNGLGTGE-----LANTISINATNIESFRNCTKINGNINIIRTSFDGDSYTKT--------PKMHPSQLDVFKTVREISG-----YLLIQQWPENLHSLSPFENLEIIRGRTK---RGSRSLVVAGLSITSLGLRSLKEISDGDVIITMNKNLCYTSESHWKKLFRSEG------QSATIKENADVATCAQRN-NICDRKCTAEGCWGPGPDMCFTCSDYSRGGSCVDSCNILEGESRETVVNKTCVKCHPECERMNGT-TTCSAPGSGNCTRCANFQDGLFCVSRCPRGVP------------------------------------------------------------GEDDMLVWKYAD------------------------------------------------------------NNKVCQLCHRNCTQGCTGPGLAGCQD---------------------------------------------------------KSTSGFSLIAAGVVGGLLAVLLAGLSVFVLLRRRHIKRKRTMRRLLQERELVEPLTPSGEAPNQALLRILKEPEFKKIKVLGSGAFGTVYKGLWVPE-GEDVKIPVAIKVLREATSPKANKDILDEAYVMASVEHPHVCRLLGICLTST-VQLITQLMPFGCLLDYVKENK--DNVGSQYLLNWCVQIAKGMN--------------YLEERHLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKTPQHVKITDFGLAKLLNADEKEYHADGG---KG-----------------------------------VTVWELMTFGTKPYDGIPASEIAGILEKGERLPQPPICTIDVYMIMVKCTW----------GWMINAVNRPRFRELIAEFTKMARDPSRYLVIQGDDRMHLPSPT------DKKLFRTLISGEG--LGGRGRCRRVFGAPAWILQQP---------------------------------------------------------------------------------------------------------------------KHFSHASA-PLY---NYMNQNGASDMMNPNYKYP-GPPRSILP-TISSDDTESEYLN----------------CFKNGTIQPEYLNEVPSS------------------------SNFPFTPN--------------------TQKYAPQNSIDNPDYQQD----------------------------------------------FTP-TFKTHTNGHIPAAE-----------------NTEYTSV---------------------
>Takifugu rubripes EGFR
------------------------------------------SFKYAMAARFVTGFGLTSLLCLCCCVLAERKVCQGITNRLNLLGSREDHYANMLKTYSNCTVVLENLEITYMEE-DRDLSFLR-------------------------------------------------------------------SIEEVGGYVLIALNTVSKIRLDNLRIIRGHSLYEKKFALSVIANFN----------KSTGQGTSELLLNSLT-----------------------------------------------------------EILKGGIKISG-KVLCNVE--TIQWYDIVNVE-----TKPVMELPVASNNPQCQKCDSSCF------NGSCWAPGPQNCQTLTKLNCAQQCSK--RCKGTSPIDCCNEHCAAGCTGPRPTDCLACRDFQDDGVCKDSCPGLMRYDPNLHQLVPNPHGKYNFGATCVKTCPHNYVVTDHGACVRTCSGNTYE-----VDEGGMRKCAKCEG-LCP--KVCNGLGTGE-----LTNAMSINATNIESFRNCTKINGNIAIIRTSIHGDAYTKT--------PKMHPSQLDVFKTVKEITG-----YLLIQTWPDNISSLSPFENLEIIRGRTK---RGSRSLMVANLGITSLGLRSLKEISDGDVIIMKNKNLCYTSKSHWKKLFKSDS------QHPTIDENADAATCAQRN-NSCDRKCTAEGCWGSGPDMCFACSNYSRGGSCVDSCNILEGEPREAVVDKTCVECHPECERMNGT-ATCIAPGSGNCTRCANSQDGLFCVSRCPQGVP------------------------------------------------------------GEDETLVWKYAD------------------------------------------------------------NNKVCQLCHKNCTQGCTGPGLAGCQN---------------------------------------------------------KSTSGFSMIAAGVVGGLLAALIAGLSVFVLLRRRHIKRKRTMRRLLQERELVEPLTPSGEAPNQALLRILKEPEFKKIKVLGSGAFGTVYKGLWVPE-GEDVKIPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTST-VQLITQLMPYGCLLDYVKENR--DNIGSQYLLNWCVQIAKGMN--------------YLEERHLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKTPQHVKITDFGLAKLLNADEKEYHADGG---KVPIKWMA---LESILNRTYTHQSDVWSYGKYCIYLCVTVWELMTFGTKPYDGIPASEIAGILEKGERLPQPPICTIDVYMIMVKC-------------WMIDADSRPRFRELIAEFTKMARDPSRYLVIQGDERMPLPSPT------ENKLFRTLISEEY--MEDAIDADEYLVPQHGFFSSPS---------------------------------------------------------------------TSHTPLLQST-VSCFMQNNEGFKSDE---FAGRDGSFVHRYIPDPTDKLLDDAFQ-PAP---DYMNQNGVSDVMNPNYKYP-GPPRSVLP-TISSDDTESEYLN----------------CFKNGTIEPEYLNEVPSS------------------------SGFPFTPNNV---------------VQNMQKYAPQNSIDNPDYQQD----------------------------------------------FTP-TFKTHTNGHIPAAE-----------------NTEYLGPD--------------------
>Danio rerio EGFR
-----------------------------------------------MAGPTEIGLFFTLLLSGSFCATPEKKVCQGANNKLTLLGTVEDHYQVLLRMYRNCTVVLENLEITHITE-KYDLSFLK-------------------------------------------------------------------SIQEVGGYVLIAVNTVSKIPLENLRIIRGHSLYEDKFALAVLVNYN----------NSIEQGVKELPLTSLT-----------------------------------------------------------EILKGGVRFNMNNHLCNVG--TIEWADILNMK-----SLPTIVSHNISYGKNCGKCDPSCF------NGSCWGTGPDKCQRMTKVICAEQCSG--RCKGPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCPHNYVVTDHGACVRTCSPGTYE-----VDEGGVRKCKRCEG-LCP--KVCNGLGMGP-----LANVLSINATNIDSFENCTKISGNVAILSTTFRGDPHTNT--------SGLDPAKLSVLSTVKEITG-----YLMIQLWPESMQSLSAFENLEVIRGRTKT--QGTYSFAVTKTAITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWKRLFKSKQ------QSVKMIENMDAATCANQN-STCNEMCTADGCWGPGPTMCFGCEHYSRGKHCVASCNLLNGEPREYEVNKTCMECDPECLLMNET-QTCNGPGPDKCTVCANYKDGPHCVHRCPQGVP------------------------------------------------------------GEKDTLIWKYAD------------------------------------------------------------VTHVCQPCHENCTQGCTGPDLKDCKD---------------------------------------------------------FKSSGLPMIAAGVVGGLLAFVILALGVAVLLRRRHIRRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVHKGLWVPE-GENVKIPVAIKVLREATSPKANKEIMDEAYVMASVEHPHVCRLLGICLTST-VQLITQLMPYGCLLDYVRENK--DRIGSQHLLNWCVQIAKGMN--------------YLEERHLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVKTPQHVKITDFGLAKLLNADEKEYHADGG---KVPIKWMA---LESIQHRTYTHQSDVWSYG-------VTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKC-------------WMIDAESRPRFRELIAEFTKMARDPSRYLVIQGDDRMHLPSPS------DSKFYRSLMSGE---LDEAVDADEYLVPNHSFFSSPS---------------------------------------------------------------------TSRTQLLHSVSLNSSFGNCNSRNGNG---YPVRENSMVLRYIPDPTERFQEGDFQ-PAPGYNEYMNQN-ESSMINPVYQQPHGPPRTLLHSSPALDETEEEYLN----------------CFKS--PAPASVVEYLNT------------------------SHTQLLST------------------------KPFFSMDNPDYQQD----------------------------------------------FCPLELKTHTNGHLPAAQ-----------------NQEYMGLEVH------------------
>Drosophila melanogaster(CG10079-PA)
----------------------MMIISMWMSISRGLWDSSSIWSVLLILACMASITTSSSVSNAGYVDNGNMKVCIGTKSRLSVPSNKEHHYRNLRDRYTNCTYVDGNLELTWLPNENLDLSFLD-------------------------------------------------------------------NIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVT------------YSKMYTLEIPDLR-----------------------------------------------------------DVLNGQVGFHNNYNLCHMR--TIQWSEIVSNG-----TDAYYNYDFTAPERECPKCHESCTHG-------CWGEGPKNCQKFSKLTCSPQCAGG-RCYGPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGH-LLRDNGACVRSCPQDKMD---------KGGECVPCNG-PCP--KTCP-------------GVTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITG-----YLNIEGTHPQFRNLSYFRNLETIHGRQLME-SMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPE------QKVWVNENLRADLCEKNG-TICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISN--AYKFDNRTCKICHPECR-------TCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIG----------ACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHP-ECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPE-GENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQ-MMLITQLMPLGCLLDYVRNNR--DKIGSKALLNWSTQIAKGMS--------------YLEEKRLV-----------------------------------------------------------HRDLAAR-------------------------------------NVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGG---KMPIKWLA---LECIRNRVFTSKSDVWAFG-------VTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSC-------------WHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYT---------------------SQDEKDLIRKLAPTTDGSEAIAE--------------------------------------------------------------------PDDYLQPKAAPGPSHRTDCTDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIG----------------VPVSVDNPEYLLNAQTLG-----------------------VGESPIPTQT-------------------IGIPVMGVPGTMEVKVPMP---------------------------------------------GSEPTSSDHEYYNDTQR-----------------ELQPLHRNRNTETRV-------------
>Caenorhabditis elegans(Let-23)
-----------------------------------MRYPPSIGSILLIIPIFLTFFGNSNAQLWKRCVSPQDCLCSGTTNGISRYG-TGNILEDLETMYRGCRRVYGNLEITWIEANEIKKWRESTN----------------------------------------------STVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVFHDN-ALYIHKNDK----------------VHEVVMRELR-----------------------------------------------------------VIRNGSVTIQDNPKMCYIG-DKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESCN-------DKCWGSGDNDCQRVYRSVCPKSCSQCFYSNSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPPE-LLIENDVCVRHCSDGHHY-----DATKDVRECEKCRSSSCP--KICTVDGHLT-------------NETLKNLEGCEQIDGHLIIEHA--------------------FTYEQLKVLETVKIVSE-------YITIVQQNFYDLKFLKNLQIIEGRKLHN-VRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGK--DNKPSLAIAENRDSKLCETEQ-RVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKCDTKG--FLRNQTSMKCERCSPECETCNGLGELDCLTCRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKG------------------DIAQCVSECPKNLPFSNPANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLKIAEMVDMPELTPIDASVRPNMSRICLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQ--TDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK--ENLGAREQVLYCYQIASGMQ--------------YLEKQRVV-----------------------------------------------------------HRDLATR-------------------------------------NVLVKKFNHVEITDFGLSKILKHDADSITIKSG---KVAIKWLA---IEIFSKHCYTHASDVWAFG-------VTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRC-------------WMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAE------ERFQTERIREMFDGNIDPQMYFDQGSLPSMP----------------------------------------------------------------------------SSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGSTAQEDNSYLIPKTKEVQQSAVLYTAVTNEDGQTELSPSNGDYYNQPNTPSSSSGYYNEPHLKTKKP----------------ETSEEAEAVQYENEEVSQ-------------------------KETCL-----------------------------------------------------------------------------------------------------------------------------------------------------