>Homo_sapiens_CROCC
--------------------------------------------------------------------------------
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----------------------------------------------------------MSLGLAGAQEVELTLETVIQTL
ESSVLCQE-------------------------------------------KGLGARDLAQDA-QITSLPALIREIVTRN
LSQPESPVLLP------ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AVSERLEQALRLEPGELETQEP--RGLVRQS
VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRDTEH----
----------------------------------------------------------------------SQDLESALIR
LEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN---AYFSNEHSRLLL
LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQAL---LQAQLEEQLRDKV
LREKDLAQQQMQSDLDKADLS-------ARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEA---------LESLRLQEQA
ALETEDGEG-------LQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG--------
------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL
RD----KTDGAMQAHEDAQREVQRLRSANELLS----------------------------REKSNLAHSLQVAQQQAEE
LRQER----------EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRR--ELERSHRQLEQ-------LEGKRSVLAKEL
VEVREALSRATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ
-------------------------LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE
ALEQQLPTLRHERSQLQ---------------------EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA
KEHAGLAVQLVAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTG--
--ELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQREKEAAWRELEAERAQL
QSQLQREQEELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES-------------------------
--------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLATISLEMER
QKRDAQSRQEQDRS-------TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLR-------------
----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQEAGELRRS
LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE
LRRQMK--------------------------------------------------------------------------
------------------------------------------------------------------------MLDSENTR
LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV---MRQELQVAQRKLQEQEGEFRTRE----------RR
LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR-AAEAQLGGLRSALRRGL
GLGRAPSP-----------------------------APRPVPGSPARDAPAEGSGEGLNSPST-------LECSPGSQP
PSPGPATSP------------------------------------------------------------------ASPDL
DPEAVRGALREFLQELRSAQRE----RDELRTQTSALN-RQLAEMEAERDSATSRARQLQKAVAESEEARRS---VDGRL
SGVQAEL-ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK---------------------
------------LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV
KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTACEHDRQVLQERLDAAR
QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE------------------------------
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-----------GEAAALNT-VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS
HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV-----------------------------------------
--------------------------------------------------------------------------------
--VVLEQSHSPAQLEVDAQQQQ--LELQQE------VERLRSAQAQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE
LRRSSAPFSPPSGPPEK---------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Pan_troglodytes_CROCC
--------------------------------------------------------------------------------
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----------------------------------------------------------MSLGLAGAQEVELTLETVIQTL
ESSVLCQE-------------------------------------------KGLGARDLAQDA-QITSLPARIREIVTRN
LSRPESPVLLP------ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AVSERLEQALQLESGELETQEP--RGLVRQS
VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRDTEH----
----------------------------------------------------------------------SQDLESALIR
LEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFN---AYFSNEHSRLLL
LWRQVVGFRQLVSEVKMFTARDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQAL---LQAQLEEQLRNKV
LREKDLVQQQMQSDLDKADLS-------ARVTELALAVERLQKQNLEKDQVNKDLTEKLEA---------LESLRLQEQA
ALETEDGEG-------LQQTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRG--------
------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL
RD----KTDGAMQAHEDAQREVQRLRSANELLS----------------------------REKSNLAHSLQVAQQQAEE
LRQER----------EKLQAAQEELRRQRDRLEEEQEDAVQDGVRVRR--ELERSHRQLEQ-------LEGKRSVLAKEL
VEVREALSRATLQRDMLQAEKTEVAEALTKAE-AGRVELELSMTRLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ
-------------------------LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE
ALEQQLPTLRHERSRLQ---------------------EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA
KERAGLAVQLVAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTG--
--ELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQREKEAAWRELEAERAQL
QSQLQREQEELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES-------------------------
--------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLATISLEMER
QKRDAQSRQEQDRS-------TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLL-------------
----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQEAGELRRS
LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE
LRRQMK--------------------------------------------------------------------------
------------------------------------------------------------------------MLDSENTR
LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV---MRQELQVAQRKLQEQEGEFRTRE----------RR
LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR-AAEAQLGGLRSALRRGL
GLGRAPSP-----------------------------APRPVPGSPARDAPAGGSGEGLSSPST-------LECSPGSQP
PSPGPATSP------------------------------------------------------------------ASPDL
DPEAVRGALREFLQELRSAQRE----RDELRTQTSALN-RQLAEMEAERDSATSRARQLQKAVAESEEARRS---VDGRL
SGVQAEL-ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK---------------------
------------LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV
KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTACEHDRQVLQERLDAAR
QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE------------------------------
--------------------------------------------------------------------------------
-----------GEAAALNT-VQKLQDEQRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS
HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV-----------------------------------------
--------------------------------------------------------------------------------
--VVLEQSHSPAQLEVDAQQQQ--LELQQE------VERLRSAQAQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE
LRRSSAPFSPPSGPPEK---------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Gorilla_gorilla_CROCC
--------------------------------------------------------------------------------
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----------------------------------------------------------MSLGLAGAQEVELTLETVIQTL
ESSVLCQE-------------------------------------------KGLGARDLAQDA-QITSLPARIREIVTRN
LSRPESPVLLP------ATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AVSERLEQALRLESGELETQEP--RGLVRQS
VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELE--QQRLRDTEH----
----------------------------------------------------------------------SQDLEGALIR
LEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTSDWTRSRKELEHREAAWRREEESFN---AYFSNEHSRLLL
LWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTDLRLAESRAEAALEKQAL---LQAQLEEQLRDKV
LREKDLAQQQMQSDLDKADLS-------ARVTELSLAVKRLQKQNLEKDQVNKDLTEKLEA---------LESLRLQEQA
ALETEDGEG-------LQQTLRDLAQAVLSDSESGVQLSGSERTTDASNGSLRGLSGQRTPSPPRRSSPGRG--------
------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRL
RD----KTDGAMQAHEDAQREVQRLRSANELLS----------------------------REKSNLAHSLQVAQQQAEE
LRQER----------EKLQAAQEELWCQRDRLEEEQDDAVQDGARVRR--ELERSHRQLEQ-------LEGKRSVLAKEL
VEVREALSRATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQ
-------------------------LEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE
ALEQQLPTLRHERSRLQ---------------------EQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALA
KERAGLAVQLVAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTG--
--ELAGLRQQIIATQEKASLDKELMAQKLVQAEWEAQ------ASLWEQQAAHEEDFQR--LQHEKEAAWRELEAERAQL
QSQLQREQEELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES-------------------------
--------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLATISLEMER
QKRDAQSRQEQDRS-------TVNALTSELRDLRAQREEAAAAHTQEVRRLQEQARDLGKQRDSCLR-------------
----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKLRESQEGREVQRQEAGELRRS
LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE
LRRQMK--------------------------------------------------------------------------
------------------------------------------------------------------------MLDSENTR
LGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEV---MRQELQVAQRKLQEQEGEFRTRE----------RR
LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR-AAEAQLGGLRSALRRGL
GLGRAPSP-----------------------------APRPVPGSPARDAPAGGSGEGLSSPST-------LECSPGSQP
PSPGPATSP------------------------------------------------------------------ASPDL
DPEAVRGALREFLQELRSAQRE----RDELRTQTSALN-RQLAEMEAERDSATSRARQLQKAVAESEEARRS---VDGRL
SGVQAEL-ALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETK---------------------
------------LEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV
KAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTR----DKNLHLQKALTACEHDRQVLQERLDAAR
QALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQE------------------------------
--------------------------------------------------------------------------------
-----------GEAAALNT-VQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRS
HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQV-----------------------------------------
--------------------------------------------------------------------------------
--VVLEQSHSPAQLEVDAQQQQ--LELQQE------VERLRSAQAQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE
LRRSSAPFSPPSGPPEK---------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Mus_musculus_CROCC
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----------------------------------------------------------MSLGLAGSLQAQLALEIVIQSL
ENCVLGPNQE-----------------------------------------KSLSVQNRVQDF-QGASLLVCAREVIASN
LSRPETPAPLQ------VPEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AVNERLEQAVRLETGELEAQEP--RGLVRQS
VELRRQLQEEQS----SYRRKLQAYQEGQQRQAQLVQRLQAKILQYKKQCSELEKQLMDRSTELE--QQRLRDTEH----
----------------------------------------------------------------------SQDLDSALLR
LEEEQQRSASLAQVNAMLREQLDQANLANQALSEDIRKVTSDWTRSCKELEQREAVWRREEESFN---TYFSSEHSRLLR
LWRQVMGLRRQASEVKMGTERDLLQLGGELVRTSRAVQELGLGLSASLHRAESKAEAALEKQKL---LQAQLEEQLQAKL
LREKDLAQLQVQSDLDKADLS-------ARVTELALSVEHLQNQNSEKDQVNRTLSDKLEA---------LESLRLQEQT
TLDTEDGEG-------LQQTLRDLAQAALSDTESGVQLSSSERTADTSDGSLRGFSGQRTPTPPRHS-PGRG--------
------RSPRRGLSP-----ACSDSSTLTLIHSALHKRQLQVQDMRGRYEASQELLGSVRKQLSDSEGERRGLEEQLQRL
RD----QTAASAQAQEDAQREAQRLRSANELLS----------------------------REKGNLTHSLQVTQQQAKE
LRQEL----------EKLQAAQEELKRQHNQLEDAQEDSVQEGARARR--ELERSHRQLEQ-------LEVKRSGLTKEL
VEVREALSCAILQRDVLQTEKAEVAEALTKAE-AGRAQLELSLTKLRAEEASLRDSLSKMSALNESLAQDKLELNRLIAQ
-------------------------LEEEKVALLGRQQQAEHATTMAVEKQELLEQLRLEQEVERQGLQGSLCVAEQARE
ALEQQILVLRSERSHLQ---------------------EQLAQLSRQLSGRDQELEQALRESQRQVEALERAAREKEAMA
KERAGLAVKLAAAEREGRTLSEEAIR-----LRLEK--EALESSLFDVQRQLAQLEARREQLEADSQALLLAKETLTG--
--ELAGLRQQVTSTEEKAALDKELMTQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQHEKEAAWRELQAERAQL
QGQLQQEREELLARM-------------EAEKEELSKEIAALQQERDEGLLLAES-------------------------
--------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLAAISLEMER
QKRDAQSRQEQDRN-------TLNALTSELRDLRAQLEEATAAHAQTVKELEERTGNLGRQREACMR-------------
----------------EAEEL-------------RTQLRVLEDTRDG-LRRELLEAQRKGRDSQDSSEAHRQEASELRRS
LSEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARVSVAKEAGELRASLQEVERSRLEARRELQE
LRRQMK--------------------------------------------------------------------------
------------------------------------------------------------------------TLDSDNGR
LGRELADLQGRLALGERTEKESRREALGLRQRLLKGESSLEA---LKQELQGSQRKLQEQEAEFRARE----------RG
LLGSLEEARGAEKRLLDSARSLELRLEAVRAETSELGLRLSAAEGRAQGLEVELARVEAQRR-VAEAQLGGLRSALRRGL
GLGRVSSS-------------------------------------PAREAPAGGSGDGLSSPSP-------LEYSPRSQP
PSPGLIASP------------------------------------------------------------------APPDL
DPEAVRDALRDFLQELRSAQRE----RDELKVQTSTLS-QQLVEMEAERDHAASRAKQLQKAVAESEEAWRS---ADRRL
SGAQAEL-ALQEESVRRSKRECRATLDQMAVLERSLQATESELRASQEKVSKMKATEAK---------------------
------------LESDKRRLKEVLDASESRSIKLELQRRALEGELQRSRLGLGDREAHAQALQ--DRVDSLQRQVADSEV
KAGTLQLTVERLSGALAKVEESEGNLRSKVQSLTDALTQSSASLSSTQ----DKNLHLQKALSTCEHDRQVLQERLDAAR
QALSEARRQSSSLGEQVQTLRGELASLELQRGDAEGQLQQLQQALRQRQE------------------------------
--------------------------------------------------------------------------------
-----------GEAMALRS-VQKLQEERRLLQERLGSLQRALAQLEAEKRDLERSALQFDKDRVALRKTLDKVEREKLRS
HEDTLRLNAERGRLDRTLTGAELDLAEAQQQIQHLEAQVD----------------------------------------
--------------------------------------------------------------------------------
--VALEGNHNPVQPEAGEQQ----LELQQE------VERLRSAQVQTERTLEARERAHRQRVSGLEEQ-VSTLKAQLHQE
LRRSSASVSLPPGTPEK---------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Rattus_norvegicus_CROCC
--------------------------------------------------------------------------------
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--------------------MASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AINE---------------------------
-----------------------------------------------------------------------RDTEH----
----------------------------------------------------------------------SQDLDRALLR
LEEEQQRSASLAQVNDMLREQLDQANLANQTLSEDICKVTSDWTRSCKELEQREATWRREEESFN---AYFSSEHSRLLL
LWRQVMGLRRMASEVKMGTERDLLQLGGELVRTSRAVQEVGLGLSASLQRAESRAEAALEKQKL---LQAQLEEQLRAKL
LREKDLAQLQVQSDLDKADLS-------ARVTELALSVEHLQNQNTEKDQVNRTLSDKLEA---------LESLRLQEQT
TLDTEDGEG-------LQQTLRDLAQAALSDTESGVQLSNSERTADTSDGSFRGLFGQRTPTPPRHSSPGRG--------
------RSPRRGLSP-----ACSDSSTLTLIHSALHKRQLQVQDMRGRYEASQDLLGSVRKQLSDSEGERRGLEEQLQRL
RD----QTATSVQAQEDAQREAQRLRSANEILS----------------------------REKGNLSHSLQVAQQQAED
LRQEL----------EKLQAAQEELRRQHTQLEDQQEDTVQEGARARR--ELERSHRQLEQ-------LEVKRSGLTKEL
VEVREALSCAVLQRDVLQTEKAEVAEALTKAE-AGRAQLELSVTKLRAEEASLRDSLSKMSALNESLAQDKLELNRLIAQ
-------------------------LEEEKAALLGRQQQAEHATSLAVEKQERLEQLRLEQEVERQGLEGSLCVAEQARE
ALGQQILVLRSERSHLQ---------------------EQVAQLSRQLNGRDQELDQALRESQRQVEALERAAREKEAMA
KERAGLAVQLAAAEREGRTLSEETIR-----LRLEK--EALESSLFDVQRQLAQLEARREQLEADSQALLLAKETLTG--
--ELAGLRQQVTATEEKAALDKELMTQKLVQAERETQ------ASLREQRAAHEEDLQR--LQREKEAAWRELQAERAQL
QGQLQQEREELLARM-------------EAEKEELSEEIAALQQERDEGLLLAES-------------------------
--------------------------------------------EKQQALSLKESEKTALSEKLMGTRHSLAAISLEMER
QKRDAQSRQEQDRN-------TVNALTSELRDLRAQLEEATAAHAQQVKELQEQTGNLGRQREACMR-------------
----------------EAEEL-------------RTQLRLLEDTRDG-LRRELLEAQRKVRDSQDSSEAHRQEASELRRS
LSEGTKEREALRRSNEELRTAVKKAESERISLKLANEDKEQKLALLEEARMSVAKEAGELRASLQEVERSRLEARRELQE
LRRQMK--------------------------------------------------------------------------
------------------------------------------------------------------------TLDSDNGR
LGRELADLQSRLALGERTEKESRREVLGLRQKVLKGESSLEA---LKQELQGSQRKLQEQEAEFRARE----------RG
LLGSLEEARGAEKKLLDSARSLELRLEGVRAETSELGLRLSAAEGRAQGLEVELARVEAQRR-VAEAQLGGLRSALRRGL
GLGRVSSS-------------------------------------PAREAPAGGSGDGLSSPSP-------LEYSPRSQP
PSPGPVASP------------------------------------------------------------------APPDL
DPEAVRDALRDFLQELRSAQRE----RDELRVQTSTLS-QQLAEMEAERDHAASRAKQLQKAVAESEEAWRS---ADRRL
SGAQAEL-ALQEESVRRSRRECRATLDQMAVLERSLQATESELRASQEKVNKMKATEVK---------------------
------------LESDKRRLKEVLDASESRSIKLELQRRALEGELQRSRLGLGDREAHAQALQ--DRVDSLQRQVADSEV
KAGTLQLTVERLSGALAKVEESEGTLRSKVQSLTDALAQSSASLTSSQ----DKNLYLQKALSTCEHDRQVLQERLDAAR
QALSEARRQSSSLGEQVQTLRGELANLELQRGDAEGQLQQLQQVLRQRQE------------------------------
--------------------------------------------------------------------------------
-----------GEAVALRS-VQKLQEERRLLQERLGSLQRALAQLEAEKRELERSALQLDKDRVALRKTLDKVEREKLRS
HEDTLRLNAERGRLDRTLTGAELDLAEAQQQIQHLEAQVV----------------------------------------
--------------------------------------------------------------------------------
--EVLERNHSPVQVEADEQH----LELQQE------VERLRSAQVRTERTLEARERAHRQRVSGLEEQ-VSTLKAQLHQE
RHRSSASMSPPSGTPEK---------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Canis_familiaris_CROCC
--------------------------------------------------------------------------------
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----------------------------------------------------------MSLGLEESSEAQPTLETVIQTL
ESSVLRAGQE-----------------------------------------EGLSAQDPAQDAPRTAGLPARIREIVTRN
LSQPDSQAPLP------ATEMASVLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AVSERLEQAVRLESGELETPEP--RGLVRQS
VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQAKTLQYKKKCSELEQQLVERSTELE--RQRLRDTEH----
----------------------------------------------------------------------SHDLESALVR
LEEEQQRSASLAQVNSMLREQLDQASSANQALSEDIRKVTTDWTRCRKELEQREAAWRREEESFN---SYITNEHSRLLL
LWRQVVGVRRLVSEVKMSTERDLLHLGGELARASRAIQEADLGLSAGLRLAESRAEAALEKQAL---LQTQLEEQLRDKV
LQEKDLAQLKVQSNLDKANLS-------ARVTELALTVERLQNQNLEKDQVNKVLTEKLEA---------LESLRLQEQA
AVETEDGEG-------LQQTLRDLAQAVLSDVDSGVQLSGSERTADASDGSLRGLSGPRTPSPPRRASPGRG--------
------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQIQDMRGRYEASQDLLGTLRKQLSDSEGERRSLEEQLQRL
RD----KTDGATQAHEDAQREAQRLRSTIGLLS----------------------------REKDSLACSLQAAQQQAEE
LQQER----------EKLQAAQEELRRQRDQLEEEREATAQDSARTRR--ELERSHRQLEQ-------LEVRRSGLAKEL
VEVREALSCATLQRDVLEAEKAE-AEALSKAE-AGRVELELSMTKLRVEEASLRDSLSKLSALNESLAQDKLGLNRLVAQ
-------------------------LEEEKAALLGRQRQVEQEASLAREEQERLEQLRLEQEVEQQGLEGSLRVAEQARE
ALEDQLPTLRQERCRLQ---------------------EQLAQLSRQLSGREQELEQARRETQRQVEALDRASREKEALA
RERAGLAVQLAAAEREGRTLSEEATR-----LRLEK--EALEGSLFEVRRQLAQLEARREQLEADGQALLLTKEALTG--
--ELVGLRQQVTTTEEKAALDKELMAQKLVQAEREAQ------ASLREQRVAHEEDLQR--LQQEKEAAWRELEAERAQL
QSQLQREREELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES-------------------------
--------------------------------------------EKQQALSLKESEKTALSEKLMGTQHSLAAISLEMER
QKRDAQSRQEQDRS-------TVNALMSELRDLRAQLEEAADTHAQEVKRLQEQARNLERQRESSTR-------------
----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRQVREGQDGREAQRQEASELRRS
LSEGVQEREALRRTNEELRAAVKKAESERISLKLANEDKEQKLALLTEARVAVGKEAEELRAGLQEVERSRLEARRELQE
LRRQMK--------------------------------------------------------------------------
------------------------------------------------------------------------MLDSENAR
LGRELVELQGRLTLGERTEKEGRREALGLRQKLLKGEASMEA---VRQELQGAQRKLQEQEGEFRARE----------RG
LLGSLEEARGAEKQQLDHARSLELKLEAARAEIAELGLRLSAAEGRGQGLEAELARVEAQ-RRADEVQLGGLRSALRRGL
GLGRSPSPPP-----------------------------LPSTSFPTGSAPAGGSGEGLRSPSP-------LERSPGCEP
PSPGPTTSP------------------------------------------------------------------ASPDL
DPEAVRGALREFLQELRSTQRQ----RDELRAQMSALS-RQLAELEAERDNATSRVRQLQKAVAESEEARRG---VDARL
SGAQAQL-ALQEESVRRSERERRAALDQVATLERSLQATESELRASQEKISKMKANEGR---------------------
------------LENDKRRLKEVLDASEGRTIKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVASLQRQVADSEV
KAGTLQLTVERLSGALVKVEESEGLLRDKVQGLTEALAQNSASLTSSQ----DKNLHLQKALTACEHDRQVLQERLEAAR
QALSEARKQSSSLGEQVQTMRGELADLELQRAEAEGQLQQLQEVLRQRQE------------------------------
--------------------------------------------------------------------------------
-----------GEAAALHT-VQKLRDERRLLQERLDSLQGALAQREAEKREVERSALRLEKDRVALKRMLDKVEREKLRS
HEDTVRLNAERGRLDRTLTGAELELAEAQRQIQLLEAQV-----------------------------------------
--------------------------------------------------------------------------------
--VALEQDQSPG---RLEADEQRQLELQQE------VERLRSAQVRTERTLEARERAHRQRVRGLEEQ-VSTLKGQLHQE
LRRTSASFPSASGP------------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Felis_catus_CROCC
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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----------------------------------------------------------MSLGLEESVEAQLALETVIQTL
ESSVLRAGRE-----------------------------------------KGLSEQDPAQDS-QLACLPARIREIITRN
LSQPENQAPLP------AAEMASVLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AVSERLEQAVRLESGEPETQEP--TGLVRQS
VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQAKTLQYKKKCS-----ELEQRCP----TSPTQDTEH----
----------------------------------------------------------------------SHDLESALIR
LEEEQQRSSSLAQVNSMLREQLDQANSANQALSEDIRKVTSDWTRSRKELEQREAAWRREEESFN---TYISNEHSRLLL
LWRQVVGLRRLVSEVKMSTERDLLQLGGELARTSRAIQEADLGLSAGLRLAESRAEAALEKQTL---LQAQLEEQLRDKV
LQEKDLAQLQVQSNLDKANLS-------ARVTELALTVERLQNQNVEKDRVNKALTEKLEA---------LESLRLQEQA
ALETEDGEG-------LQQTLRDLAQAVLSDMESGVQLSGSERTGDASDGSLRGLSGPRTPSPPRRSSPGRG--------
------RSPRRGPSP-----ACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSEGERRSLEEQLQRL
RD----KTSGATQAHEDAQREAQRLRGAIDLLN----------------------------REKDSLARSLQAAQQQAEE
LRQER----------EKLQAAQEELRRQRDRLEEEREDTARDSERTRR--ELERSHRQLEQ-------LEMKRSGLAKEL
VEVREALSCATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLRVEEASLRDSLSKLSALNESLAQDKLGLNRLVAQ
-------------------------LEEEKAALLGRQRQVEQEACLAREAQERLEHLRLEQEVEQQGLEGSLRVAEQARE
ALEHQLPTLRQERCRLQ---------------------EQLAQLSRQLSGREQELEQARRETQRQVEALERAAREKEALA
KERAGLAVQLAAAERESRTLSEEATR-----LRLEK--EALESSLFEVQRQLAQLEARREQLEADGQALLLAKETLTG--
--ELVGLRQQMTTTEEKVALDKELMAQKLVQAEREAQ------ASLREQRAAHEEDLQR--LQREKEAAWRELEAERAQL
QGQMHREREELLARL-------------EAEKEELSEEIAALQQERDEGLLLAES-------------------------
--------------------------------------------EKQQALSLKESEKTALSEKLMGTQHSLAAVSLDLER
HKRDAQSRQEQDRS-------TVNALTSELRDLRAQLEEAAAAHAQEAKRLQEQARNLDRQRESSVR-------------
----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKVRDSQDGREAQRQEASELRRS
LGEGVKEREALRRSNEELRAAVKKAESERISLKLANEDREQKLVLLTEARVAAGREAEELRAGLQEVERSRLEARRELQE
LRRQMK--------------------------------------------------------------------------
------------------------------------------------------------------------VLDGENTR
LGRELVELQGRLALGERAEKEGRREALGLRQKLLKGEASLEA---IRQELQGAQRKLQEQEVEFRARE----------RG
LLGSLEEALCPGSPFADFCSSGCFILKEVLVYTARAGVGVFVWEMESPGEEVVVGRHPAPGPVAVDGAVGQLRCHLRRQE
GLGPALS-----------------------------------------MPPPPGSGEGLSSPSP-------LERSPGSEP
PSPGPATSP------------------------------------------------------------------ASPDL
DPEAVRGALREFLQELRSAQRQ----RDELQAQTGVLS-RQLAEMEAERDSATSRARQLQKAVADGAEGEWRGACRPPRV
SSGPASS-CVKEGGQQSSPRDDTQALLYHTMQLLGLALGS--DAAEQEKISKMKANEVK---------------------
------------LESDKRRLKEVLDASESRTIKLELQRRSLEGELQRSRLGLSDREAQAQALQ--DRVDSLQRQVADSEV
KAGTLQLTVERLNGALAKMEESEGALRDKAQGLSEALAQSSANLTSTQ----DKNLHLQKALTACEHDRQVLQERLEAAR
QALSEARKQSSSLSEQVQTMRGELADLEVQRAEAEGQLQQLQEVLRQRQE------------------------------
--------------------------------------------------------------------------------
-----------GEAAALHA-VQKLQEERRLLQERLDGLQRALAQLEAEKREVERSALRLEKDRVALKRMLDKVEREKLRS
HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQLLEAQV-----------------------------------------
--------------------------------------------------------------------------------
--VALEQDQSPA---RLEAAEQQQREVERE------VERLRSAQVQTERTLEARERAHRQRVRGLEEQ-VSTLKGQLQQE
LRRSSASFPQTSGPPGE---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Myotis_lucifugus_CROCC
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------MSLGLGGSLEAQLALETVIQAL
ESSVLGPGQE-----------------------------------------TGLSVQDPAQDC-QPAPLPALLREIVTGS
FSKPESPALLS------ATEMASMLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AVSERLEQAVRLESGELETQEP--RGLVRQS
VELRRQLQEEQA----SYRRKLQAYQEGQQRQAQLVQRLQAKILQYKKKGSELEQQLLERSTELE--QQRLRDTEH----
----------------------------------------------------------------------SRDLESALIR
LEEEQQRSSSLAQVNAMLREQLDQASSANQALREDIRKVTSDWSRSRKELEQREVAWRREEESFN---AYFSNEHSRLLL
LWRQVVGVRRLVNEVKMSTERDLLQLGGELARTSRAVQEAGLGLSAGLQLAESRAEAALEKQAL---LQAQLEEQLRGKV
LQEEGLAQLQMQSNLDKADFN-------ARMTELALTVERLQNQNLEKDRVNKALTEKLEA---------LEALQLQEQP
ALDTEEGEG-------LQQTLRDLAQAVLSDMESGVQLSGSEHTADASEGSLRGLSGPRTPSPSRRSSPGRG--------
------RSPRRGPSP-----ACSDSSVLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSEGERRALEDQLQRQ
RD----KTDGATQAQEDAQREAQRLRSAIDLLN----------------------------REKDSLAHSLQAAQQQAEE
LRQER----------EKLQVTQEELRRQRDQLEEEKEDTEQDRARARR--ELERSTRQLEQ-------LEVKRSGLAKEL
VEVREALSCATLQRDMLQAEKAEVAEALTKAE-AGRMDLELAMTKLRAEEASLRDALSKLSALNESLAQDKLGLNHLVAQ
-------------------------LEEEKAALLGQQRRVEQEATLAREEQERLEQLRLEQEVDRQGLEGSLRVAEQARE
ALEHQVPTLRQERCRLQ---------------------EQLAQLSRQLSGREHELEQARRETQRQVEALERATREKEALA
KERAGLAVQLAAAEREGRTLLEEATR-----LRLEK--EALESSLFEVQRQLAQLEARREQLEADGQALLLAKEALTG--
--ELAGLRQQMTMAEEKAALDKELMAQKLVQAEREAQ------ASLREQRAAHEEDVQR--LQREKEAAWRELEAERAQL
QSQLQREREELLARL-------------EAEKEELSEEILPSEQSPQRPHVSADP-------------------------
--------------------------------------------PQKEALSLKESEKTALTEKLVGTQHSLTAISLEMER
QKRDAQSRQEQDRG-------TMNTLTSELRDLRAQLEEAAAAHAQEVKRLQEQARDLGRQRESCVR-------------
----------------EAEEL-------------RTQLRLLEDARDG-LRRELLEAQRKVRESQDGREAQRQEAAELRRS
LGEGAKEREALRRSNEELRAAVKKAESERISLKLANDDKEQKLALLEEARVAMGKEAGDLRAGLQEVERSRLEARRELQE
LRRQVP--------------------------------------------------------------------------
------------------------------------------------------------------------SAARHPPR
GGQGLAQQTGNKLVGMCTETWASGHRVGRWPCWLSPSHLRPL---PLPQLQGAQRKLQEQEGEFRARE----------RG
LVGNLEEARSAEKQQLDHARSLELKLEAARAEAAELGLRLSAAEGRGQGLEVELARVKAQ-RRAAEAQLGGLRSALRRVL
GLGRAPSPALS-------------------------STGRQALGSLARCPPIRGSGDGPSSPSP-------LERSPGSEP
PSPGPATSP------------------------------------------------------------------TSPDL
DPEAVRGALRDFLQELRSTQRE----RDEFRAQTSALS-RQLVEMEAERDSATLEG----KAAAEGSIARRS---VDGRL
SGAQAEL-ALQEDSVRRSERERRAALDQVAALERSLQATESELRASQEKISKMKANEVK---------------------
------------LESDKRRLKEVLDASESRTIKLELQRRSLEGELQRSRLGLSDREAQAQALQ--ERVDSLQRQVADSEV
KAGTLQLTVERLNGALAKVEESEGALRDKVKGLSEALAQNSASLTSSVGNL-KELINEREGLWASPAVWLTLQERLEAAR
QALSEARKQSGALAEQVQTMRGEMADLELQRAEAEGQLQQLREVLRQRQE------------------------------
--------------------------------------------------------------------------------
-----------AEAAALHT-VQKLQDERRRLQERLGGLQRALAQLEAEKREVERSALRLEKDRVALKKTLDKVEREKLRS
HEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQLLEAQV-----------------------------------------
--------------------------------------------------------------------------------
--VVLEQDQSPVGLEALEAEEQQQLELQQE------VERLRSAQVQTERTLEARERAHRQRVRGLEEQ-VSTLKGHLQQE
LRRSSASFSPASGPPEK---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Monodelphis_domestica_CROCC
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------MSSRDEGPPVASPKLETVIQKL
ESSLLT---SE---------------------------------------EEKDLTVQDPGQDGAPSRLPACIREIVTRN
LSEPENPETVQ------TPEMASLLSLQEENHILQQELSRVEDLLAQSRAERDELAIKYN--------------------
-------------------------------------------------AISERLEQSLRLESG--EREPLGYGVLGQQT
LELRRQLEEEQA----NYKRKLQAYQEGQQRQAQLVQKLQAKVLQYKKKCGDVEQQLLEKSTELEQQKLAQ----E----
-------------------------------------------------------------------EEHSQDLENALIR
LEEEQQRSASLLQVNAMLREQLDQASVANQALTDDIRKVTSDWTRSRGELEQREAEWRREEESFN---AYFSN-------
----------------------------EHSRL-----------------------LLLWRQVV---G----------FR
---RLVSEMKTSTERD---------------------------------------LSQLGI-----------------EL
ART-----------------------------------------SRTIHSASLG--------------------------
------------------------------------------------------LSGSLR--LAESSSEAAMEKAALLRA
QL----EEQ----------------------LRD----------------------------KVHDLIQLQVKSDLEKAE
LSSRV----------HELTLLVEQLQKQNSEKDRANETLTQK---------VEALEAVRLQ-------EQAAMEAEEVEA
LRT---------ESEVLQQTLRDLAQAVLSDT-DSGIQMGGLERTPETSDGSLR--GLSSLRTPSPLRRSSPRPS----G
-------------------------SPRPSLSPAFSDSTLAL------------------VHSALHKRQMQVQVGSPATA
EPCPVSKGKE-----------------------------------------KEDVGPSRGFPFCSWSG--DGGRS-----
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Takifugu_rubripes_CROCC_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------EKKLTVRGPSPDAPPACLPARVREIVTKN
LSESRELPQS-----LAAGAMSSVMSLQEENRVLQGELARLEDLLAHSRADRDELAIKYS--------------------
-------------------------------------------------AISER--------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------DEQSSNLEDALIR
LEEEQQRSSSLSAVNAMLREQLEQAGIANEALSQDIRRLTTDWTKAREELEQKESDWRREEESFH---SYFSSEHSRLLM
LWRQVVGFRRNVCELKNGTERDLSDMRNELARTCHSVQVSCSSLSSVLHSREGGAVLALEREKS---LRLQLEQQLRERV
---GEMMNFQTKADAEKSGLS-------LRLSDLLRESERLKGQIEERDTEIAVLMRKLKE-----------------QS
VNDETDMQMMKTHTESLLDTLRDIAQVSCNTNMLAVRGRGLLQEGDSSSEADQENSGTPLLALFH------S--------
-----SSTRRSTSPSRSSSQALLTDSALCALRSAVTNKTLQLQDVRGRLISSQSSIQQLRKQLSESDLAKREAEQRIQSL
QR----ERDAAQREKETTLKEKERLKEDRDVLAS----------------------------EKVSLEKVVQAAQGSSQL
LEMES----------KKLQLIVASAQRERDHEREQKEAAVLERDRAKA--ETQRIQKQLEQ-------SESRLSSQRGEL
SAVRETHQKGEVERQVLEGERAQLSEALARAE-SRNAELSLLLNKLQSEEAALRDSLAKVGSLNESLAQDKADLNTYILQ
-------------------------LEEEKSVLQAQKREAQQQKLTIRDELR-LEQDRLELDAARITLQHSLQDVELSQV
GVDAELQSLREEKVKLQ---------------------ERVTQLCSEVSSLGSELSLAKGEGQRSEVALEEAGRSRAELA
RDKAALVVQLTASEKENTALSEELAA-----FRSER--ESLETSLFEMQQQLVQAESRREQLEAENQNLRLRSETAAV--
--ELRRLRSDGENVLAQAEREKQALTQTLNAAQLEAQ------QALHKAVSEHQEEVER--LVSEKEALRDSLLMEQESA
LRKLRQEMEEPLHRA-------------EREREELQEELRSLQHDRDQSLLQAET-------------------------
--------------------------------------------EKQQALSLKETEKAVLSDRVSCLQAELTAAALEAER
MSREAALYKEQEQI-------RVAALNSELQALRSQLEDASSLHERELQSAREACTDLQSHTDVALK-------------
----------------ELDQC-------------RAALAANEETRDQ-LKRDVTDAERRQNQTVDTLETCRREVSELRRN
LADITHEKDTLSHSNILLRETVRSAESERISVKRQHEEKEQKLSVLEESFASVQKEVTELRGCLREVERSRLEARRELQE
LRRKLK--------------------------------------------------------------------------
------------------------------------------------------------------------VLDGEKEQ
KEREVAELQTRLLLEEQREEEKAKELFAVRHKLTEAETARDF---LKKELSMTQKRLVESESSWRSGE----------RE
LSAQLQEARGCEKKLQDEAKNLALRTQAAQDSAAQSGLLLSETQGRLAATEAELIRAEAGKK-DLEFRLNSIQSALTRTL
GIGASGRRGRG--------------------RSPGG-----SSTSPGTISRHQSISPLRTSLSPPKEIQVCTPDTTLNSG
AASPERGEAP--------------------------------------------------------------LPLPQPEL
DPDALRSDLRDFMQELRETQRE----RDDAKCRVGLLE-RELEEMLGDQDSTQSRLTHLQKAFQEYQEGKRG---LEERL
STTQILL-QQQEEAVRRADRDRRAVTDRLRDLERALQVSETDKKNMQDQLNKQRAAEMR---------------------
------------LDSERRRLREALEAAEARATRVELGRRSLEGELQRLKLSLGDRETESQNSQ--ERYDSLMKQLSEGEA
RTSLLQRETERLSHSLLKSQEDESILKEKISSLRKSLQEAAASHSSHQS----RLAALQKMLTEVEHDKRLLQEQLEEAR
VSAAEGKRSSASISERIQSLQGELSHSERRREELEAELRSTQELLQQRTA------------------------------
--------------------------------------------------------------------------------
-----------SLTEAQRS-AQSAQVERATVEERLRGLQRAVAMLETEKKDAERQAVRLEKDKNALRNTLDKVERQKLMT
EESSMRLSAAKGRLDRSLNTAEQELQEAQQQILMLQTQL-----------------------------------------
--------------------------------------------------------------------------------
-------ADLEQSHGLCESLVRQREEAQRE------AERLRSSFREAEQTLGARERAHRHRVKGLEEQ-VSTLKEQLLQE
MKRRQPSLPSPLMPAGN---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Tetraodon_nigroviridis_CROCC_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------QRL
EESVLS--------------------------------------------EEKKLTVRGPSPDGPPACLPARVREIVTKN
LSESACVSG--------AGAMSSVMSLQEENRVLQGELARLEDLLAHSRADRDELAIKYG--------------------
-------------------------------------------------AISERLEQALRFDTADGDCDAAEPRSLAQQT
LDLRRRLEEEQA----AYKRKLTAYQEGQQRQAQLVQKLQAKVLQYKKRCGDLEQILQEKTSELDKHLLS-----Q----
-------------------------------------------------------------------DEQSSNLEDALIR
LEEEQQRSSSLSAVNAMLREQLEQAGVANEALSQDIRRLTADWTRAREELEQKESDWRREAESFH---TYFSSEHSRLLM
LWRQVVGFRRNVCELKNGAER-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Gasterosteus_aculeatus_CROCC_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------AMSASGNSDSDSNKLESVIQRL
EESVLS--------------------------------------------EEKRLTVRGASPDAPPTCLPARVREIVTKN
LNETCEWPQSALPSCITSGAMSSVVSLQEENRVLQGELARLEDLLAHSRADRDELAIKYG--------------------
-------------------------------------------------AISERLEQALRFETGDGDHDSPESLGLVQQN
VDLRRRLEEEQA----SYKRKLTAYQEGQQRQAQLVQKLQAKVLQYKKRCGDLEQMVQERSTELEKHRLS-----Q----
-------------------------------------------------------------------DESSSNLEDALIR
LEEEQQRSSSLSAVNAMLREQLEQAGLANEALSQDIRRLTADWTKAREELEQKESDWRREEESFH---SYFSTEHSRLLM
LWRQVVGFRRHVCELKSATERDLSDMRNELARASHSAQVSCAGLSAALQGREGGAALALEREKA---LRLQLEQQLRERV
---AETMTLQTRADSERSELN-------VRLTESAREAERLKGQIEERDREMVVLVRRLEE-----------------QS
GHNESDMQAMRSHTETLLDTMRDIAQT-------------VLSDTESSSEADQDNSGVPLLALIRGFSSHRT--------
-----SSPRRSSSPSRPSSLAPPSEAALSALCSAVTNKTLHLQDVRGRLLSAQSAVQQLRKQLSEADSAKRDSEQRNQHL
QR----ERDAAQREREITQRDKDRLKQERDTLAS----------------------------EKLSLEKNLQAAQSSTQI
LQMDC----------EKLQLTVASTQRERAHDREEKEAANQERERAKA--ETQRIQKQWDQ-------SESRASAQRAEL
SAVKETYQQAEIERQLLERENAQLTEALARAE-GSNAELSLLLNKLQSEEAALRDSLAKMGSMNEGLAQDKTQLNNYILQ
-------------------------LEEDKARLQAQKREAEQEKLTIRDELVRLEQDRLELDSGHTTLHQSLQDAELSRA
GTEAELQGLRAETFKLR---------------------ETVTQLCAEVTSLESELSLARGESQRNQVALEETGRGRAELV
RDKAALVVQLTASERENAVLSEELTA-----FRSER--EQLETSLFEAQQQLVQVESRREQLETENQNLRVRCATAAA--
--DLRRERSDGENVVTQAERDKKLLTQTLNAAQLEAQ------QALRKAISDHQEEVER--LVSEKEVVRHSLLMEHEGT
LRRLHMEAEDQLRRA-------------EREKEELLDELRSLQHDRDQSLLQAET-------------------------
--------------------------------------------EKQQALSLKEAEKTVLSDRVSSLQAELSAAAVEAER
MSREAAQYKEQEQI-------RIGSLTSELLELRSQLEDAASVHERELHSLQETCTDLQSRADVALK-------------
----------------ELDQC-------------RASHLAHEDSRDQ-LRRELLDCERRLNQCQDAAENSRREGTELRRN
LADVSKERDTLGQSNTQLRVTLRSAETERISVKRQCEEKEQRLAVLEDNLSCNLKEVTDLRSCLREVERSRLEARRELQE
LRRQLK--------------------------------------------------------------------------
------------------------------------------------------------------------VLDGEKEQ
MGREVAELRRRVSLEEQREEERGKELFTLKQKLTEAETARDS---LKKEISATQKRLAESESGWRGCE----------RN
LTAQLQEARGCEKKLQDEAKNLALRAQAAQDSAAASSLQLSEAQGRLAATEAELTRAEAGRR-DLEYRLSSLQSALTRTL
GIGAGGRGGRG--------------------RSPGGRSPGGSSTPPGPMSRHHSVSPLRSSLSPPKD-------------
----------------------------------------------------------------------------DPEL
DPDTLRSDLRDFLQELREAQRE----RDDARCQLGGLR-RELEELSGGRESALIRLTHLENMLQECQEGKRG---VDERL
TTTQVLL-QQQEEVVRRGDRERRALSDRVNDLERALQTSEMDRKHTQDQLNKQRATEVR---------------------
------------LEAEKRRLREALEAAEARATRVELGRRSLEGELQRFKLSFGDREADSQASQ--GRHDALLKQVAEGDA
CVSLLQRDVERLSQALLKAQDGESFLREKTSSLKKSLQEAEASHSSTQS----CLASVQKMLSVAEQDKRLLQERMEEAR
GSLVEAKRNMVILTERVQSLQSELDQSELKREAVEAELNNAKEALRQRSA------------------------------
--------------------------------------------------------------------------------
-----------SAAEAQRS-AQSAQKERAAFEERLRGLQRAVAMLETEKKDAERQAVRLEKDKDALRNTLDKVERQKLKT
EEGSMRLSAEKSRLDRSLNTTEQEVQEAQQQILILQTQL-----------------------------------------
--------------------------------------------------------------------------------
-------AETEQSHGLCESLARQRDDAQRE------AERLKAGLRDAERTLGTRERAHRHRVKGLEEQ-VSTLKEQLQQE
MKRRQPSLPSSLLSAGK---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Oryzias_latipes_CROCC_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------KAMSAAENSDSDPSKLESVIRRL
EESVLS--------------------------------------------EEKRLTVRGPSPDDPPACLPARVREIVTKN
LSDSSLMCVCA------AGEMSSLMSLQEENRVLQGELARLEDLLAHSRADRDELAIKYG--------------------
-------------------------------------------------AISERLEQALRSETGEGEADSQASRSLAQQN
VELRRRLDEEQA----AYRRKLTAYQEGQQRQAQLVQKLQAKVLQYKKRCGDLEQKLQEKSSELEERSETSNGRHH----
-------------------------------------------------------------------EDSSSSLEEALLH
LEEEQQRSSSLSAVNAMLREQLEQAGLANEALSRDIRRLTADWTKAREELEQKESDWRREEESFH---SYFSSEHGRLLT
FWRQVVGFRRHVCEMKSSAERDLSDMRGELVRMSHLVQVSCAGLSAVLRSQEAGTALALEQERA---LRDQLEQQLRGQV
---KETMNLQSRADAERSELS-------LRLSDAAQENERLKSQMEERDREIDNLSRRLEE-----------------QS
RSDETDSQLLRAHCNALLDTLKDIAQT-------------VLSDGESSSEADPDNSAVVLQALIR------D--------
-----SSPQRSSQTS--SSLSPLPEAALSALRSVVTNMMLQLQDVRGRLLSAQSSAQKFRKQLSEIDSAKRDADQRNQAL
QR----DKDAALRERETAQREKEQLKTMSPTPS-----------------------------EKANLEKAVQALHSSNQM
LQMDY----------EKLQLAVASAQRERDREREEKEAAIHDGERWKT--EIQRIQKQRDQ-------SESRASAQRGEL
SAVLQTHQQGEVERQLLEQESAHLSEALARAA-STNKELSLHLSKLQYEDAALRDSLTKMGNLNEGLVQDKVDLNKYILQ
-------------------------LEEEKAVLQAQKREAEQEKLSIRDELVRQEQNRLELESSRVTLQQSLQDTEFSRV
GVEAELQNLRAERLKLQ---------------------EKVAQLCGEVASLDSELSLAKGEGQRSEMALEEAGRSRAELT
KDKAALVVQLTASERENAMLAEELTA-----FRSER--ETLETSLFDAQQQLLQAESCREQLEAENQNLRVRCETATV--
--ELRRLRSDAENQLAQAERDKQALTQALSAAQLEAQ------QASRKATSEHQEEVER--LALEKEVVRHSLQMEHETA
VRKLRQEVEDQLQKA-------------RREKEELQDGLRALQHERDQSLLQAET-------------------------
--------------------------------------------EKQQALSLKEAEKTVLLEKVSGLQADLSALSLEAER
TAREAAQYKEQEQI-------RVGALTSELQELRSQMEDAAAGHERDILSLNETCADLRSRADVALK-------------
----------------ELEQC-------------RASLSAAEENREQ-LRRDFLETERRLTQTQEASENHRREGAELRRS
LCDVTRERDALSQSNAQLREALRSAETERISVKRQCEEKEQRLVVLEESLSSSQKEVAELRSCLREVERSRLEARRELQE
LRRQLK--------------------------------------------------------------------------
------------------------------------------------------------------------VLDADREQ
KGRELAELQTRLSLEEQREEERGKEVFILKQKLAETQTARES---LKRELSMTQKRLVESESGWRSCE----------RE
LTAQLQEARGCEKKLQDEAKNLSVRAQAAQESAAQCSLQLSEAQGRLTATEAELTRAEASKR-DLEFRLSSLQSALTRTL
GIGASGRASRG--------------------RSPGG-----SSASPGSISRHHSISPLRPSLSPPKG-------------
------GGTP--------------------------------------------------------------LPPAQPEL
DPDTLRSGLRDFLQELRDAHRQ----RDDAQCQLMTLQ-RELEEQKLERECAENRSTQLQNSLKECQEGKRG---LDDRL
TSTQILL-QQQEDAVKRVDRERRALADRVRELERSLHTAEMEKKHTQEQLNKQRATEAR---------------------
------------LEAERKRLREALEAAEARATRVELGRRSLEGELQRLKLGLGDREAESQASQ--ERHDCLLRQVAEGEA
QVSLLQTEVDRLSQALLKAQEGEAALKQKVTTLSQSLQEAAADHSSTQT----RLTALQKTLSLVEQDKRLLQEKMDEAR
TSVTEAKRSMFALTERVQSLQGELTQSELLREELEAELKNTQEALRQRSG------------------------------
--------------------------------------------------------------------------------
-----------SLAETQHS-IQKAQTERAAVEERLLALQRAVALLETEKKDAERQAARLEKDKDALRNTLDKVERQKLKC
EEGSMRLSAEKTRLDRSLNAVEQELQEAQQQMLMLQTQL-----------------------------------------
--------------------------------------------------------------------------------
-------AEMEQAHSGCEGLLRQRDEAQQE------AEKLRNSCKDLERTLSTRERAHRHRVKGLEEQQVSTLKEQLQQE
MKRRQPPLPSTFTST-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Anopheles_gambiae_CROCC
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MTTVLNGKDCAPSLG
LRHSEGGGGGG---------GGSALADRSKKPFSRPFNKSRLQHEPSSTTTGGGVSGTGGP-------------------
-----------------------------------------------PATTARMPSSTGSSSGPPS---AADTSALIRQN
NELRHRLQEEANN----YRRRLETYKQAQNNQAALVSRLQAKVLQYKQRCSDLEQ-LPPSAGSCSGGGGGGGGGRYAGGS
GSREPSPGSRHLHHAHHAPSPPPSAGGGGGGGPICTDVTGGPLSLPSACPVARERARSRSRSQSPCRKYSEGSHDEIRHQ
LDEERRRCEKLLVENSCLRQQLEESHRTNEALTNDLQKLTNDWESLRDELLSKEDEWKEEEQAFN---DYYNNEHTRLLK
MWREVVQVRRMFNEMTSTTKMELGRMHLELSGTVREVSGACSGVSVNLKQSSKFEEAQQMHIER---ENI----ELKSQL
SELRLQFEAAKQEIGQRDQRLQ-------QMAQELKLLDDRYTQADSQAAQAHRMNDELER-------------------
----------------LQAALRDIAHAVVQDAETSASADMGGCGGGSAGEGGQHHLHLSQPIVSPGVAPRSPKRA-----
-----SGGMAGTGGS-LRASQAFAEGTISAVQAALHKYQLAIHDLQVKLQTNNDALKATRKQYDSCEHARDTLSGKVSEL
TE----KLDSANHQLSELYKERDSLQKTLDGLRS----------------------------DKHTVERGKAELNSIVDS
LNTDY----------EKLQNVNSKLQKMYDALEEEKKMIELELQRVHK--DKDIQELNLRA-------EEERCSRLREET
ITLREELNKLYLSRDLLEQQRIESDGLLNMLE-KQKLELEFELDRVTGERNELHSTLEKRTNSNEHQEQEIRQLKTTVAQ
-------------------------LDEERGKLRAQSSDQSADLASLKKELISAEQARLDLDSEKLAISERLKCLEMEKD
KIEAELSCVARERNDLS---------------------NQLATISRKKETIGEEVMRLRQRLEQSNEMNGRLNRSLEELV
KESEEKTVTIEGHEKELQRLQEQLAS-----LRSEK--ESLEAVLFDTNTSLEEAEAKKDALERENQDLLIKQESHKA--
--LIARLNKDLENAERRAQDIKIQLTNAAANQEAEFL------QKLSNLRTFSEENIKK--LNDEKEQIRQSLEKRMQQS
LQALESAKDAEIRQL-------------REQFETLQLHLDALNQQHEEVILRAEN-------------------------
--------------------------------------------EKQQALLIAHRDKQAVIEKLEVTARELKNELENGDR
LKREMAARQEKDRT-------TIGCLRDEVTKMRTKAEEARIRAEEEMNRLEVVAGSLREEKETLLK-------------
----------------DAEEL-------------KVQLRLSEDRCDA-LNHQLQDTHRKLKEAENSTDATRKDLTDTRRT
LADSNIERDKYANSNKELRDHVKRVEEQRRQQARTIEDALAKISSLEETRNGLEQDKVRLQTILKETETNVTKLNQELSN
AQTDIQ--------------------------------------------------------------------------
------------------------------------------------------------------------KFQTDTTQ
KDASEKELQARLANEGEEKERVLAELHQIKKQMADLEGTLCA---TRQELGRARCKANQDEHRFHQRE----------QE
LCARNEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGAEGRVRALDEQLVQLECQKK-EVENKLSSIGHTLRRIA
GIQMDGSVSLP------------------------------YRLMSPSRRYSPARGGTGGRSEGGEHHHHDRHHHGHHHH
HHGHETRSLS--------------------------------------------------------------GENVLIDV
DPEMVRKGVRSLMQQIAHIERE----RDDFKVQLCTAR-KQLQEGSDAQLRLETKINKLQQHVRAVHEDKTN----LEAR
LAQKTSALQSTEETLRQKSDELTALREKATQLEQSLTSTSEERTHLEERLDKCRQSGAR---------------------
------------LESDKRHLQDELARTEARATKLDLQRVALEGDIQRLQMAMQEKDCTVRNQQ--ERLENQQRSLTQLED
RCVALKSTVDQLKERLQAAAITETELRGEISGLQRHNADQSHTFALGQ----DKLKQLQKTLSGSENERRVLAERLDAAQ
HTINELRRNQQASQDSTTRLQEQLAECEVQKSTLESQLRLAKWNQETSEQLAATGGNLGGGSGGA---------------
--------------------------------------------------------------------------------
-------GGNTSGDQELTRQLISSQRERNELRNKVEALNEKIRTLERDQQ---RPAGKYDRSEK---------KSGEYDS
NRIES-------TTYSCGLDHAQLEQEGRELRMKVRRLET----------------------------------------
--------------------------------------------------------------------------------
--LLAEKEAELARSRAKLLESPSKASSLGGGSVGADVERYRSAQVQAERLLDAREQSHRQQVTRLENQ-IAMLREQLAQE
AKRRQQYILRSSRAGREMQQLRQTIGDSLRNVA-------------------------------QDP-LDTSLLESEARR
LDSAVS--MSLPPTTSATGRGRGEYDRSLSPTFR----------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Hydra_magnipapillata_CROCC
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------MSFLDEKPPSDKSNDEDLPSLQSIIKRL
EE--------------------------------------------------------------------NEIKIPTKET
LTNSEIPISMRDVTKVMSNDVADAEKLIEENRLLYDDLLWSQNQLSLMKSEKSSLNSSKLPLYN----------------
-----------------------------------------------DYMRMQSPVNSSYNNESVRIQSPVSSFLSVENY
ILQINQLKQKIEDDHSNYKRKLHAYQEGQEKQSELIQKLQSKVQQYKMRNNELEMIANDKSNELEELRDKLQVTIASAKE
YEKRLMEFD----------------------------------------------------------EDRSNEMENYAVQ
LEEEKQRNVNLQHANNMLHEQLEQATSANSHLSLETQKLSIELTKSCDELKHRDSEEEN----------YFTEEHRKLVN
LWNSIDSFRSAFNIVKLETQKDLLQVKAEFSKSARTIQAASMELEKTQRGLSTVNQNTLLEEQA---QREKVESQLREKI
RELIDLQATLNKMKDHYEIR----------LDEITNSLTESKARVDEQQKTIGLYKNKLKQLG------IEYSETTENWK
NDSQVNIEAMREEIEVLQSTLYELANCILEDADSTSSSLDYLLSKVEAEIDTDNDIDPSSKVKDIVQSSSPLIH------
-------VKLRSKSPVRARSPAYIQSLVAGSQSAMKKRQLQLQEQKRQLDIAVMDKQSFKRQFDISSSKLQQLNTAYDEL
KT----DHLSLQSKYNKSNEDCNKYRNQLQIIEK----------------------------EKQSFENMKNHLQNKVEE
YEHKVN----------QLENQISYLKNNHENESEKKDSIMNEVSRLSN--ESQQLQKVIAD-------LECKQSMLKEEC
VDLKEKLNRASLEKDVFLQENTHLQELLKSAQ-DERDDLENDVNKLKMDEVQLKDALVKLQTLNEALGEDKLNLGKIVLQ
-------------------------VEAERDQIYKEKENLESEKLGLKEELLRIDKEKASLESERKGILEAINLNDATIE
KLEEQLQEACFSKNKMN---------------------DTLNNVVREKEVSQYELVSLRLEVERLQNSLNRLLKEKEELT
KENSLISVKLSGNLKEIQALTESNAL-----LKSEK--ETLESYLYELQHLVGKLEVRKEQLETSNHEVHLAKDTIAV--
--ELAHLKKENEIQTAKLNKENELLQQKLSLLERERD------LSLSRLKEQHEDQIHQ--LAMDKDKMLTAKKEEHLIV
INELKEEMEDYQIKA-------------ERDRLALINEVASIQRERDDLLLQAEA-------------------------
--------------------------------------------EKQAHLRAADSEKSLLVEKITKLKDDLDSANEELEI
LKRDLEERAAREKD-------LLNDSAHEIEKCKENLEETVNLYEAKLKDLVDSHDKLLKNKEELYG-------------
----------------ELSNA-------------KFQLKILNENHEA-AQKECKELTNKVIDLNGKLDDASKHTLELKRS
LKDAEVEKMLVLSGAEELREAFKQVESEKMTYKKNYEDSKKLASILDDTNVMQTRETDDLRHMISELETARQETRKEVQQ
LQNRVR--------------------------------------------------------------------------
------------------------------------------------------------------------LLDTECVK
CKKDLNIAKDQLNKTNSLLEEERLDLINTKNKLRECETSKDA---IKAEMQALATKAREHNDEFGLRE----------KD
LLMALEDARQTEVKVYDKMRQLENLLDVSNQEKSDLKLKLSSVEGRNLGLEDQLTKLEALKN-DLDSKLSNVYSALRRTL
GIKPNQSINSIN---------------------------------LLVHLRPSQMSLRNVAHLTLGNRVYLQSSHDQSSE
FDETPPSKNV--------------------------------------------------------------SFETSNEM
DPEYVRNSLREFAQKFKDLEHE----RDEALINIGGLQ-RQLENLEMDRLDYENRLSVLQKSLQDTAEDKRG---ADGRL
SSAQTAL-LLQEETIRRLERERKTAEEKFQILESTVAQLETEKRTLKEKYMKAHKHKLK---------------------
------------YEQEAEAMRSQIDGAESRITRTDLKKKSLEGDIDRLRSQLHDAENEKHATK--QRLEILQRTCKDLEL
KSSSLQLTVDRLNMSLSKSTDQEHLLQSKVTELSAIISEKQSVVVSLQ----DKLQQTERIIVSNEQEKQAAFEKVENLK
KQLLENKKLNDLQNDKILNLRNEIANLESTRINLESELRQVQTLLQKNKV------------------------------
--------------------------------------------------------------------------------
-----------GDEELLNK-LEKFKEEKKNLQERLAQQQRLLAQGEQEKRDIEKNSVKVEKEKRALKATVEQLEKEKFLI
DEELIQLKNDQTESDKIRSNYEQTINSLRIQLSQLQETL-----------------------------------------
--------------------------------------------------------------------------------
-----EEKELQHNKKLASMSARHRDDLMKE------IERMKSSQQSLDRTYDARERAHKQRIRGLEDQ-INTLKDQFAKE
IQQKQSFINRTTQKNEEIQEIRQKINSSINEVA-------------------------------RNADPRILDRESQKLD
TTYDNYNDFSAVLTASTPYSNRMKVSPFIIDKYSSMTPTTDPGLMSSRIDLPITTEARNLSNTTFVSPIRKNLGKK----
--------------------------------------------------------------------------------
-------------------
>Homo_sapiens_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------MSSASSEPGNGDASQQPLLGLDTVIQRL
EDTILSPTASR---------------------------------------EDRALTVRGEGRQASPTPVPTRIREIVAGS
LSEEPPQAGVQEPT-------ATVARVQEENELLQEELTRLGDLLAQASAERDELASRCR--------------------
--------------------------------------------------VVSEQ-------------------------
--------------------------------------------------------LQARLETTEAQLRRSELEHS----
-----------------------------------------------------------------------VDLEEALGR
LEAAEERSTGLCQVNALLREQLEHMKKANDALGRELAGMTGSVQRLQGELELRRWAQRQ-------TRSGGLGQPRDLLL
LWRQAVVLGTDLAELRVATERGLADLQADTARTARRLHTACLNLDSNLRLSASSTASTLGQQ-------------LRDKA
GEMLQLQGRWDAEKVALQAR----------LSEQTLLVEKLTEQNEQKAKTIAALRTDLQN-------------------
-------------------------LVAQED----------ARCLELAGSSITELGEPRRPLRSPQRATSPHQG------
------------ASPPHICSPATLDPALQAMRAAIERRWRREQELCLQLKSSQALVASLQEQLSESRRELWAAQKLQQER
AREQAREREALRGQLEAQRLEVQQCRASCKLLGREKA----------------------------ALEMVVEELKGKADA
ADAEK----------QGLEAEAAELQRSLLLQAERREELALRRERSCR--ALETSQGRLQQ-------LEEKVSGLREEL
ASVREALSTAQLQRDVVESEREGLRSALARAE-CSNADLELLVRRLKSEGVEQRDSLAAMAALMEGLAQDKSALNHLALQ
-------------------------LEQERDQLREQRKTLEQERARAGEQLAQAEQQLALERAERRGLQQACGRLEQRQE
QLEGQAALLGREKAQLQ---------------------EQVGQVTCQKQALEEQLAQSLQDQEAQMGTLQQALQGKDALS
EERAQLLAKQEALERQGRLAAEEAAD-----LRVE--RDSLESSLLEAQQLATKLQ---EQLEEEARSAGLARQALQ---
-VEMEQLQSDWEVQEMKLRQDTVRLQRQVAQQEREAQ------RALESQALAHREALAQ--LQREKETLSLTLAEEKEVA
RCQLEQEKE-LVTKS-------------AAEREALKGEIQSLKQERDESLLQLEHKM-----------------------
--------------------------------------------QQVMALSLKETERS-------LLSEELSRARRTLER
VQQEAQSQQEQAQA-------TISATTEELKALQAQFEDAITAHQRETTALRESLQDLAAERGDVER-------------
----------------EAERL-------------RAQLTVAQEG--------LAALRQELQGVEESREGLHREAQEARRA
LSDEAREKDVLLLFNSELRATICRAEQEKASFKRSKEEKEQKLLILEEAQAALQQEASALRAHLWELEQAGGDARQELRE
LHRQVR--------------------------------------------------------------------------
------------------------------------------------------------------------TLKAENQR
RSGEA----------HELQAQCSQEVLELRRQAAKAEAKHEG---ARKEVLGLQRKLAEVEAAGEAHG----------QR
LQEHLRESRGAEQTLRAELHSVTRKLQEASGVADALQARLDQACHRIHSLEQELAQAEGARQ-DAEAQLGRLCSTLRRGL
GLQRQSPWASP------------------------------------EQPGSPTKGSDS--SQALPGQQGTSP--PARPH
SPLRWPSPTP--------------------------------------------------------------GGRSSELM
DVATVQDILRDFVQKLREAQRE----RDDSRIQMATLS-SRLSEAECRCARAQSRVGQLQKALAEAEEGQRRVEGALSSA
RAAR----ALQKEALRRLELEH---------------LASVRAAGQEKR-------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------RLQEQLETLR
QALEESRRHSQGLAKQGKLLEEQLTNLEHRCQKAEVSLEPL---------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------RQMEQETLKR
EEDVARLGAEKEQLDQSLNSLHQEVDGALRQNQQLQAQM-----------------------------------------
--------------------------------------------------------------------------------
-----TEMEQAHTQRLQDLTAQHQRDLATE------AERLHGARPQATQALESQEWTHQQQVKVLEEQVASLKEQLDQEV
QWRQQAHLGQAFQTGHAQRD------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Pan_troglodytes_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----SRSTGLCQVNALLREQLEHMKKANDALGRELAGMTGSVQRLQGELELRRWAQRQVLPQP--TRPGGLGQPRDLLL
LWRQAVVLGTDLAELRVATERGLADLQADTARTARHLHTACLNLDSNLRLSASSTASTLGQQ-------------L-DKV
GEMLQLQGRWDAEKVALQAR----------LSEQTLLVEKLTEQNEQKAKTVAALRTDLQNLVGGRDGG-----------
---GCVAGVC---HPCSGVSPATGSLVAQED----------ARCLELAGSSITELGEPRRPLRIPQRATSPHQG------
------------ASPPHICSPAALDPALQAMRAAIERRWRREQELCLQLKSSQALVASLREQLSESRRELWAAQKLQQER
AREQAREQEALRGQLEAQRLEVQQCRASCKLLGREKA----------------------------ALEMVVEELKGKADA
ADAEK----------QGLEAEAAELQRSLLLQAERREELALRRERSCR--ALETSQGRLQQ-------LEEKVSGLREEL
ASAREALSTAQLQRDVVESEREGLRSALARAE-CSNADLELLVRRLKSEGVEQRDSVAAMAALMEGLAQDKSALNHLALQ
-------------------------LEQERDQLREQRKTLEQERARAGEQLAQAEQQLALERAERRGLQQACGRLEQQQE
QLEGQAALLGREKARLQ---------------------ERVGQVTCQKQALEEQLAQSLQDQEAQMGTLQQALQGKDALS
EERAQLLAKQEALERQGRLAAEEAAD-----LRVE--RDSLESSLLEAQQLATKLQ---EQLEEEARSAGLARQALQ---
-VEMEQLQSDWEVQEMKLWQDTVRLQRQVAQQEREAQ------RALESQASAHREALAQ--LQKEK--------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Macaca_mulatta_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------MSSASSEPGNGDASQKPLLGLDVVIQRL
EDTILSPTASR---------------------------------------EDRALTMRGEGRRASPTPVPAHIREIVASS
LSEEPPQAGVQEPT-------ATMARVQEENELLQEELTRLGDLLAQAGVERDELASRCR--------------------
--------------------------------------------------VVSEQ-------------------------
--------------------------------------------------------LQARLETTEAQLRRSELEHS----
-----------------------------------------------------------------------VDLEEALGR
LEVAEERSTGLCQVNALLREQLEHMKKANDALARELAGTTGSVQRLQGELELRRWAQRQ-------TRPGGLEKPRDLLL
LWRQAGVLCG------TDGTRGLADLQADTAKTARRLHTACLNLDSNLRLSASSTASTLGQQ-------------LRDKV
GEMLQLQVRWDTEKVALQAR----------LSEQTLLVEKLTEQNEQKARTIASLRTDLQS-------------------
-------------------------LVAQED----------TQCLELS-WSITELGEPRRPLRSPQRATSPHQG------
------------ASPPHTHSPATLDPVLQAVRAAIERRRRREQELCLQLESSQAVAAGLQEQLSECRQELWAAQKLQQER
AREQAREQEALWGQLEAQRLEVQQCRASCKLLGREKA----------------------------ALEMVVEELKGKADA
ADAEK----------QGLEAEATELQRSLLLQAERREELALQRERSCR--ALETSQGRLQQ-------LEEKVSGLREEL
ASAREALSTAQLQRDVVESEREGLRSALARAE-CSNADLELLVRRLKSEGVEQRDSLAAMAALMEALAQDKSDLNHLTLQ
-------------------------LEQERDQLREQQKTLEQEQVRAREQLAQAEQQLLLEQAECRGLQQACGRLEQQQE
QLEGQAALLGREKAQLR---------------------DQVGQVTCQKQALEEQLAQSLQDQEAQMDTLQQALQDKDALS
EERAQLLAKQEALERQGRLAAEEAAD-----LRYA--RQDGPRSLPSHTPSSPALL---RAPRGGPGLQ--SRGSMV---
-EPLELLLGPHGEREAGHRLRSPSFRNMNMLRPGEPL------HSAFCHSLFFEGGFIP--PPSLPNFLTSIPCP-----
--------------------------------------------------------------------------------
----------------------------------------------VQALSLKEAERS-------LLSEELSRARRVLER
VQQEAQSQQEQAQA-------TISSTTEELKALQAQFEDAITAHQRETTALCDSLRDLSAERGDVER-------------
----------------EAERL-------------RAQLTMAQEG--------LAALRQELQSIEESREGLRREAQEARQA
LSDEAREKDVLLLFNSELRATICRAEREKASFKRSKEEKEQKLLVLEEARAALQQEASALRARLRELEQERGDARQELQE
LHRQVR--------------------------------------------------------------------------
------------------------------------------------------------------------TLKAENQR
RSGEA----------HELQVQCSQEVLELRRQAAKAEAKREG---ARKEVLGLQRKLAEVEAAGEAHG----------QR
LQEHLQESRGAEQTLRAELHRVTRKLQEASGVADALQARLDQACHRIHSLEQELAQAEGARR-DAEAQLGRLCSTLRRGL
GLWRQSPWVSP------------------------------------EQPGSPTKGSDG--SQALPGHQGASP--PARPH
SPLRWPSPTP--------------------------------------------------------------GGRSSELV
DVATVQDVLRDFVQKLREAQRE----RDDSRVQMATLS-SRLSEAECRCARAQSRVGQLQKALAEAEEGDLLGIGVLSTI
RTSLXXXXXXXXXALRRLEAEH---------------LASVRAAGQEKR-------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------RLQEQLDMLH
QALDESRRHNQGLAKKGKLLEEQLTNLEHRCQEAEGSLEPL---------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------RQTEQETLKR
EEDVVRLGAEKEQLDRSLNSLHKEVDGVRRQNHQLQAQM-----------------------------------------
--------------------------------------------------------------------------------
-----VEMEQAHTQQLRDLAAQHQRDLATE------AERLHGDQSQATQALESQEWTHQQRVKMLEEQVAGLKEQLDQEV
QRRQQAHLDQAFQTG-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Canis_familiaris_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------AHELGAAATPQCLWMAVLQRL
EDTVLSPMASR---------------------------------------EDRALTVRGEGCRASPTPVPARIREIVAGS
LGDEPHQG-VREPL-------GASARLQEENELLQQELCRLESLLAQAGAEHDELASRCH--------------------
--------------------------------------------------TASERVSG----------ARGAGPAEGRSG
RPGGGVPAPLRRLAHLAPLSPEPSV-PSEAEPLPPRQMRTRWPGAELPQAAPCS-PLQARLETTEARLRRSELEHS----
-----------------------------------------------------------------------VDLEEALGR
LEAAEQRSSGLAQVNSLLRQQLEHLRRANDGLAEELARTADGVLHLRSQLELREAQRGTGTQSQ----RPRDGGAQDLLL
LWRRATALRAQLAELRAATDRGLADMRAEAARTARRLRTACLSLDCHLRLSARGEPGAPEQQAL---QASRLERQLRDKV
REMLQLQGRWDAEKVALRAR----------LSEQTLLVEKLTEQSSKHESTIASLRADLQARESPRGGD-----------
---QRAAGVLEEEAASLRRVLRRIAEVAQAD----------AEGPLLATSGSAEAEEAGGQLRRPACSASPPPA------
------------RSP---DTPDTPEVALQAVQAAIERRRRREQELRLQLESAEARAARLREQQSGDRQELQAARRLLHE-
--------------LQAQAREAQQRPACGELLRRAPSR------------------------GSPGWGAGVAAGGKPWLR
GQREK----------RALEPAVEEMRRKEAPSRRRMRSCRGAACCGRR--FLHLSRGRLEQ-------LEEKISGLRREL
VSAQEALHLAQLQRDVVESEREGLRRALARAE-SSNTDLELLVTRLKSEGVEQRDTLARMAALTEGLAEDRSHLSHLVLQ
-------------------------LEQERDQLREQQKALEQEQAGARERLARAEQQLEQVQGQAARLQQQRAQLEQQQY
---LKTIQNLSLPSSLM---------------------SHLSNTSCKKQALEEQLAQSLRDQEAQMDTLQRALQEKEALS
EERTQLLAKQAALERQVQLTAAEAAD-----LRAE--RDSLESTLLDTQRLSGQLQAEREQLEGETQSLRLARQTLQ---
-VEMQQLKSAWEVQETKLQWDVGRLQRLVAQQEREAQ------LALESQALAHHEDLAR--LQRDKETLSLSLTEEKEVA
ARRLEEEKK-LVAKN-------------AAKREALKEEIQTLKHERDESLLQLEHEM-----------------------
--------------------------------------------Q--QALSLKEAERR-------LLEEELSRALQELEQ
VRQEAQSRHE-------RAEAAVGATDAELKALQAQFEDAVATHQREAAALSDSLREVAAERSDTRR-------------
----------------EAERL-------------QAQLDEAREA--------LAVLRRELQGREESGEGLRREALEARRA
LGDETREKDVLRRSNAELRAAIRRAEQDRASFQRAKEEGEQKLLVLEEARAAAQKEAWELRASLREVERAEADARRGLQE
LGRQVN--------------------------------------------------------------------------
------------------------------------------------------------------------MLETENRR
KSQEVSQLQARGAQDAERQQQSQ------------------------REVLRLRQELAEVEAGAEAQK----------QQ
LEERLRQSRGAERSLRAELRSVSGRLRQASGAAEGLQARLDEACGRLCGLEQELARAEAARR-DSEGQLRRLWSTLRCGL
GLQGHGPPGSP------------------------------------KPPGLPGKGSDS--SPGRSPRHRASS--PSR-A
GSPPRGPSPA--------------------------------------------------------------PGDHSSAV
DVASVRDALRDFVQRLRDAQRE----RDDWHLQVLSLS-RQLREAESARAQAQSHAGQLQTALAEAEEAWRQAEGETRTA
QAAR----ALQEEALHRLDAEH---------------LAS----------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Felis_catus_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------------VSLWTAVFQRL
EDTVLSPMASR---------------------------------------EDRALTVRGEGWPALPTPVPARIREIVAGS
LRDEPHQG-LQQPP-------AVSAGVQEENERLQEELSRLGELLAQADAEQDELAGRYH--------------------
--------------------------------------------------AVSARSFRGLRLL-RQDWAGDAPCGVLRAP
GMSGSTPTPAVFRVLLAPAGSQEGC-RLWAGLVQLWEGSVPQPPCLLARWVTLTLQLQARLETTEARLRRSELEHS----
-----------------------------------------------------------------------ADLEEALGR
LEAAEQRSTGLSQVNTLLREQLGHMKKANDRLAEELARTTDGVLHLRGQLELTEARRRAETQIR----RPRRGGSQDFLL
LWRQVTALRVQLAELRTTAERALTDMRAEMARTAGRLQTACLALGSRLRLAASSAAGALEQR-------------LRDQV
RETLQLQGRWDAEKVALQAR----------LSEQTLLVEKLTEQNSKKERTISSLKMDVQKLESRRSRGQRAADTLEDQV
EALQRVLKSITEVLAHLG-PSRGTLKVAQED----------AGCPERACSGGPEAQEAQGQVRRPGSSASPHRG------
------------VSPTRAHALDALHPALQAVHAAIERWRLLEQELRLQLGSSQAVAARLREQLSEAQRELQAARRLLQER
AQEQVREPEDLLRELEAQSLEAQRCRESSELLQREKR----------------------------ALETAVEEMRGKAAC
ADAEK----------QRLEAENTELHRSLLLWAEQKEELVQQGKRGRR--ELETSQGRLEQ-------LEEKVSGLKKEL
VSAQEALNSARLQRDVLESEREGLHRALARAVGTGLPSLTPSHTRLSVP-----SPLVTLPPLLGARAWTRTPPCPHPRQ
-------------------------LEQERERLRERQKALEQERAGALERLARAEQQLGPA-------QQACGRLEERLQ
---GREAAFERQRARLQ---------------------EQVGQVTCKKQALEEQLAQSLQDREAQRDTLQRTLQEKEALS
EERAQLLAKQEALERQVRLTAEEAAE-----LRAE--RDSLERSLFETQQLVMQLQAQREQLEGQARSMRLARQALQ---
-VEMQQLRSAWEVQETKLQWDVGRLQRQVAQQERDLQ------LALESQALAHHEDLAR--LQREKESLSLSLTEEKEVA
AHRLEQEKK-LVAKN-------------AAKREALKEEIQSLKHERDESLLQLENEM-----------------------
--------------------------------------------Q--EALSLKEEERR-------LLREELFRAMQELGQ
VRQEAQSQQK-------QAEATVSATAAELKALQARFEDAILAHQREAAALRDSLREMAAERSNAGR-------------
----------------EAEGL-------------RAQLDEAREA--------LAVLRGELQGSEESREGLRREALEARRA
LGEEAREKAVLRSSNTELRAALRRAEQDKASFQRSKEEREQKVLVLEEARAAAQKEACELRASLREVQQARADACRELQE
LGTQVN--------------------------------------------------------------------------
------------------------------------------------------------------------VLRAENPR
KGRESSEPGDRSGCDQGLQRQTR--WPQWRRRDGWLQRGRRSALMTLPQVLRLRRELEEAEAGAEARK----------QQ
LEEGLCRSRGAERTLRAELHMVTGKLQQAGSVADGLQARLDEAGRRLHSLEGELARAEGARR-HAEAQLGRLWSTLCRGL
GLRGPGPSGSP------------------------------------EWPGFPSTGSES--IQSAGPPTRSSS--PLRWP
SPAPGDP--C--------------------------------------------------------------PDVE----
DVASVRDALTDFVQKLRVAQRE----RDDWHLQVVSLS-GRLSEAERERAQAQSRAARLQEALAEAEEGGMSVEGERRRA
QAAR----ALQEEALRSLEEQH---------------RAGRRAASWEKRRLQ----------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Bos_taurus_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----PAG-LREPL-------ASLGSGPEEHTLLQDELSRLEDLLAQAGAERDELAGRYH--------------------
--------------------------------------------------TVNERGGEMLGTRGQWEYKPQKPCSQIRQP
KRGCRQLSPEDSPVVWASSRGFPATRPTWGLQAHLCQAARPAGLGSSRPGGSLPSQLQARLQATTAQLRRSELERS----
-----------------------------------------------------------------------MDLEDALGR
LEAAEQRSTSLSQVNALLREQLEQLRKAHDRLAEELARTTGSVPRLWAELELREAQRRTHREAG----RARSGQPQD-TL
LQRQVTALRGRLAELRAATEKGLADLRADVARMARRLHTACLNLSSNLRLTAGSEAAALEQQ-------------LRDKV
REMLQLQGCWAAEKAALQAR----------LAEQTLLVEKLTEQNASKERAISSLRMDVQRLESQHGGGGPTAP------
---EDSRAEVETLRLLLDSITQVQAQVAQAD----------AGSEELARSSGAEGEGAQGQRGSPLHAGNSLRA------
------------ESP------ADPDSALWAVRQAIQRWRQREQELRQQLESSEARATGLQEQLSESQRELQASRSLLQEE
RQ-------DLRGKLEAQSREAQWSRMTSELLGREKT----------------------------ALEETVEELRGEAAT
SHAEK----------QTLEARNAELQRSLRQCTEQKEALERQGERGRR--ALESSQGRLEQ-------LEGTVSGLKTEL
VSAQEALDSARLQRDILESEREGLHGALARAE-SSKADLELLVSRLKAEGVEQRDSLAKMAAVTEALAQDKGSLNHLVLQ
-------------------------LEQERDELRAQQQTLAQGQAGTREQLAQAERQVELLRAERRGLQRACGRLEERLE
RLEGQATRLRRERAQLQ---------------------EQVGQVTCKKQALEKQLAQSLQDQEAQMAALQRALQEKEALS
EERVQLLAKQEALEKQGQLMAEEAAD-----LRAE--RDALESSLFEAQQLASQLQARQEQLEGEARGARLARQALQGAA
PMKLEQLQSVQEAQET-------RLRRQAAQQERDAQ------LALESRALAHREDLAR--LQREKETLSLSLMEEKEAA
ARRLKQEKE-LVAKN-------------ATRRAALKEEIQSLRRERDESLLQLQHEK-----------------------
--------------------------------------------Q--QSPQPAQERPTPVTQALLLRDAELSRLRGELQL
VRQEAQGQQE-------QAEATISTVASELKALQAQFEDAISAHQTEARALRETLRALVAQRSSTGR-------------
----------------EAETL-------------RAQLDEAHEA--------LAALHRELQGSEETQEGLQKEARDARRA
LADAAREKDALRDSNTELRATLRRAEQEKASFKRSTEEREQKVLVLEEAWASAQKQAGELRASLREAERAAVDTQQQLQE
LRRQVT--------------------------------------------------------------------------
------------------------------------------------------------------------TLEAENQR
KSRELVRLQTRGAQEPSRQEALALQTLVAEAKAARED--------SQWEVRRLRRMLAEVEAQAKTRE----------KH
LERQLCESRGSERALWAELRGVARKLLQADGVADSLQARPDRACGRAHGLKQEPARAEGTQR-ETEDQRGQLWSMLHPSV
GLHGWSPVASP------------------------------------EPAGPPSRGQCP--PRPPSHPPGAPQ--PPRGS
PSLPEKG-------------------------------------------------------------------------
ARASMRDAQRDLTQKLWDAQWEGAGRRLSLGLQAFCLSPLALGEAESEPTWALSRIGQLQKALAVAEKGWHQVEDKLSSA
QAMW----ALQEEALPR---------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Equus_caballus_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------AERDELASRHH--------------------
--------------------------------------------------AVSER-------------------------
-----------------------------------------------------------------------DLEHS----
-----------------------------------------------------------------------VDLEEALGR
LEAAEQRSTGLSQVNALLREQLEHLKKANDTLAEELARTTGSVLHLRGELELREAQRRTERQNSN--WYLSKWEPRDFLL
MWRQVTALRAHLAELRAATERGLADMRADTARTARRLHRACLNLDSHLRLSASRAADALEQRAL---QGTRLEQQLRDKV
REMLQLQGRWDTEKVALQARWVPGSAGPPGLSEQMLLVEKLTEQNSKKERTISSLKMDVQKLVRGAGR------------
---QRPCRGVSVRLAEGS-ALAAGVPAWRRP----------AG------SGRPEGPSGD-RLRSPPRTASPYRG------
------------VSPPRTRSLAASDPALRAVQAAIQRWRLKEQELRLQLESSQAVVAGLREQLSESQQELRASRRLLQER
AQEQAREYEDLLGKLEAQSREAQHCRATSELLGREKK----------------------------ALESVVEELRGKANT
WDVER----------QRLETKNAELQRSLLLWAGQKEELVQRGQRGRR--ELETSQGRLEQ-------LEEKVSWLKKEL
LSAREALNTAQLQRDVLESEREGLRGALARAE-SGSADLELLVTRLKSEGVEQRDSLAKMAALMEGLAQDKGTLNHLVLQ
-------------------------LEQERDQLREQQKALEQERAGAQEQLAQAEQQLELVRAERRGLQQACGRLEEQLE
QLEGRAAQLRRERAQLQ---------------------EELGQVTCKKQALEEQLAQSLQDREAQMATLQRTLKEKEALS
EERTQLLAQQEALERQGRLTAEEAAD-----LRAE--RDSLESSLLEAQQLAMQLQAQQEQLEGEAQSARLARQALQ---
-VEMEQLKSTWEVQETKLQWDVGRLQRQVAQQERDMQ------LALESQALAHREDLAR--LQREKETLSLSLTEEKEVA
ARRLEQEKE-LLAKS-------------AAKREVLKEEIQSLKHERDESLLQLEHEM-----------------------
--------------------------------------------Q--QALSLKEAERS-------LLREELSRATWELER
LQQEAQSREE-------QAEATISATTAELKALQAQFEDAISAHQTEAAALSKSLREMAAERSNAGR-------------
----------------EAERL-------------RAQLEEAQEG--------LAALRQELQGSEESREGLRREALEARQA
LGDETREKDVLQLSNAELRAAVRRAEQEKASFKRSKDEKEQKVLVLEEAQAAAQKQAGELRASLREAEQARGEARRELQE
LCRQVK--------------------------------------------------------------------------
------------------------------------------------------------------------TLEAENRR
RSQEVSRLQARVAQDAQRQQQSRQEALELQRQVAEGEAAQKEPLRSLLQVLRLQRKLAEVEAGGEARE----------RQ
LEERLHESRGTEQSLRAELRGVTGQLQQAGGVADSLRTRLDEACRRVHSLEQQLAHTEGARQ-DAESQLGRLWSTLRRGL
GLGARSPSTSP------------------------------------ERPGSPTKGQCS--DGSEGHSGRHSA--SPPGP
ARPSHGPRLH--------------------------------------------------------------PEIHGPEV
DVASVRDTLRDFVQ-LRDAQRE----RDNWRLQVASLS-SRLSEAESERARAQSRMRQLQKALAEAEEGWRQAEGETSRA
RAAQ----ALQEEALQRLQTE-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Loxodonta_africana_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------ETTEARLRRSELEHS----
-----------------------------------------------------------------------VDLEEALGR
LEAAEQRSTGLAQVNTLLREQLEHMKKANDALAEELARTAGGVLRLRGELGRREERRQPNMESNGFNCVYWTGESQNLLP
LWRQATALQAYLAELRAATERGLADMRAEAARTARRLHTACLNLDPNLRLSAHSAAGAQEQQ-------------LRDKV
QEMLALQGCWDAEKVALQAR----------LSEQTQLVERLTEENTEKEGTIRALTVEVQGLESRRGRG-----------
---QPSMDDLRDQVDALRQVLNSITKVPLPSPALQGLRVFRKKGTELVQSGSTEGYEMLGQPKRPLHTTYPGPGG-----
------------LSPPQAQSPAALDPALRAVRVAIERRQQREQELRWKLEASQAVAAGLREQLSECRQELLASK----GP
LWEQAWEHEALLGELEAHRWEAQGCRASEERLGREKA----------------------------ALEAVVEELRGQVDI
SAVER----------CRLEAENVELQRSLLLCAEQGNELAQQEQRSRR--ELDTSQGHLEQ-------LEEKVSGLKKEL
VLAREALNATQLQRDVLEGENEGLRSALARAE-SSNADRELLVTRLKSEGVEQRDSLANMATLMEGLAQDKGTLNHLILQ
Q------------------------LEQERDRLREQQRVLEQEQARSLEQLARAEQQLAREQAERRSLPEGSVQLAR-EA
QLQSRWPVR-HLWAGLQ---------------------CQLPQVTCGKQALEEQLAQSLQDREAQMDTLQRAMQEKEALS
EERAQLLAKQEALERHSRLMAKETAD-----LRVE--RDSLESSLFEARQLVSKLQTQQEQLEGEAQSARLMRQALQ---
-VDMEQLKSTGEVRETKLQWDLEQLRRQVAQQERDSQ------LALESQAVAHREDLARLQREKRPGKVYKMLSKCRMAG
TEAQRGREL-KGCLC-------------RFLPPPHSSNVQRGAASSRAPVSFTCTPS-----------------------
--------------------------------------------CHLQALSLKEAERN-------LLREELSTATQELER
ARQEAQGQQERAKA-------TISTVTEELRVLQAQFTDAISTHQKESAALSTSLREVAAERSSMGR-------------
----------------EAERL-------------RAQLDVAQEG--------LAVLRRELQGVEESCEGLRREALEARRA
LADEAREKDVLQLSNTELRASIRTAEQEKASFKRSKEEHEQKVLILEEAHAAARKEAGELRAGLREVERARADARRELQG
LRRQVK--------------------------------------------------------------------------
------------------------------------------------------------------------ALEAESQR
KGQEVGELQARAARDTQLQEQGQQEALELQRRAAELEVAYEG---ARKEVLGLQRKLAAAEASGEAQE----------KQ
LTAQLRDSRAAEQTLQAEVRSVARKLRLADGTAEGLRARLDSACSRIRGLEQELAQAEGARR-DVETQLDRLCSTLRRSL
GLQGQSPVASP------------------------------------ERSSSPTKGSDG--SQAQTWRQSTSP--PAESC
SQLRWPS--P--------------------------------------------------------------GARDVEVL
DVVCVRNALRDFVQKLWDAQRE----RDDARCQAVSLS-SQLSEAESARARAQSRTAQLQEALAEAEEGQRRAEAEVSSV
QAAR----ALQEEALSRLEMEH---------------LASTRAADKERCRLQVEAQLEWAS-------------------
------------ELAGTRRRYLELPVAELPRTSAELRATSVKGNAQEELGSRGAGAAGLLRRGDGLQSVISQSAVDER--
RAALTVTRYG------AAREESNWSPCSPRREGRGLCFPLAASALQLILIR-KPLLFYEKMCTSGKWSFSNLQEQLDALH
QALDESRRHSQGLAATGRLLEGQLAGLERRCQEAEGTLEPLRQVLRRRQR------------------------------
--------------------------------------------------------------------------------
-----------GEQAAAAAEKRVLREQTAALRTERARLQGQLAALRARLAQVPSAGPGVGRTRNPGRGSQRRTERETMRR
EGTAARLEAKKEQLDQSLSALHQEVNGALRQNQQLQAQM-----------------------------------------
--------------------------------------------------------------------------------
-----AELEQAHTQRLQELAAQHQQDLAAE------AEQLHGAQLQAAQALEFRERTHQQRVKVLEQQVASLREQLDQEE
QRRRQSPQAAGSAPPSQ---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Dasypus_novemcinctus_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------------------VLQRL
ETTVLSPTASR---------------------------------------EDRALTVRGDGRGASPTPVPARIREIVAGS
LSEEPPQG-VREPP-------GAAARVREENTLLQEELSRLEDLLAQTGAERDELASKYH--------------------
--------------------------------------------------AVSERSRS-----------CSKRPPGSERV
KLGRGSVVQMGKLRQESDDARYARAPSLCQPFLERNGFAAGLGAGGHGLRAARCGQLQARLGSTGARLRRSELEHS----
-----------------------------------------------------------------------ADLEEALGR
LEAAEQRSTGLAQVNALLREQLQHMKTANDRLAEELARTTGSVLRLQGQLERGQAWRQAEREFIYFFNIQCIFVKMSFYL
SGLGFIRLLVSLIVFITLDDILVLGATLKKANCGSKSTGEIFSPSAALQNSRQSVPSLPAVFGL---AMRVQLLEYHLHV
AQRAVGAGRKHIPRGASSAR-------CHWLNEGVGAPQMWNKGRGSDNGEVAAQEARCHG-------------------
--AQQAVDSLKDKVGSLQHALSSVSKVAQAD----------TEHPQPAWSSSAEGEEVRGWPRSPLPTATPPPRG-----
------------RSPPRACSPAAPDQALQAVQTALERRRQQEQELCLRLESSQEAAAGLREQLSESRRELRASWR-----
------ECERLRGQLEARR-----CGAARELRDREKE----------------------------ALETALEQLRAKADA
ADAEK----------HRLEAANAELRRSLRGRTEQQEELARRGARSQR--ELEASQGRLEQ-------LEDKVSGLKKEL
VAAREALSAAQLRQDVLEGEGEALRGALARAE-SSNTALELLVTRLKSEGVAQRDSLAKMAALMEGLAQDKGTLNHLVLQ
-------------------------LEQERDRLQERQKALEQAGAGAREQLAGVEQQLERERAEKQGLQQACGRLEEQQG
QLEGQAAQLRHERAQLQ---------------------EQVDQVFGTRSGGESPLSCLRCPAEAEVSSVSRRAGQSEACK
HT-GGLAPVCPPLSRNGMAASERYGP-----RRAA--RDSLESSLFEARQLATQLQAQQAQLEAEAQGARRAWRDLQ---
-VEMEQLKSTWEVQGTKLRWELEQSQRQVARLERDSQ------LALDSQALAHREDLAQ--LQREKETLTVALAEEKEAA
ACRLEQERE-LVAKT-------------AGEREALRDEVRSLKQEWDESLLQLEQEL-----------------------
--------------------------------------------Q--QALSLKEAERS-------LLSQELSGATQQLEQ
AGQEARSRQEQ-------AEATVSAMAEELRALQAQFEEAISTHQREAATLNGSLREAAAECSSVGR-------------
----------------EAEQL-------------RAQLDVAQEG--------LAALRRELQSSEERGKGLRGEVLEARRA
LGDEAREKDVLQRSNAELRAAVRQAEQDRASFKRSKEEKEQKLLVLEEARAAAQKEAGELRASLREAEKARADVHRDLQE
LRRQVR--------------------------------------------------------------------------
------------------------------------------------------------------------TLEAENQR
KGQEVSTLQAQRAQDAERRRQSQREALELQRAGAEAEAAR-------KEVLQLQRKLAEAEAG-----------------
AEGHLRESRAAERALRAE--------------ADGLRARLDVACASVCSLEQELARAEGARR-DAEAQLCRLGSVLRRGL
ALGGRSTPASP------------------------------------ARPGSPTKALQPPCPAGSDGLQSASP--PAGPR
SPLRGSSPAP--------------------------------------------------------------RDHSAEAV
DVAAVQGALTDLVQRLRGAHWE----RDDARLQVVGLS-ARLGEAESGRARALSHAGQLQRALAEAEEGQRRAEAELSSA
RAAG----TLQEEQLRAGAAEKRHLQKVVAYLHFSCQCSSQPSASWEEARSPAYCDDLKLY-------------------
------------GSQKKTPEPLLASSEAPPTLLCQRAVLQGQNEPQSRILEEESSEPRPLPRHVSGIAKKGAQPRDGAGC
SREPTKRSSG------QLAKKAGSRPALPSLGVRGSARVVVTIQNTLAPAC-FPPLCIPLTARQGDPVSPLPQEQLEALR
QALEDSRRHGQGLGARGRQLEAQLADLGRRCQEADGALEPLRQVLRRRQR------------------------------
--------------------------------------------------------------------------------
-----------SDQAAERRVLREETAALRTERTRLQGELAALRARLAQVRPVPVRAQRDTVPG--CRRQVFRTESETLRR
EGDTARLGAKKEQLDQSLSSLRQEVDGALRQSQQLQAQV-----------------------------------------
--------------------------------------------------------------------------------
-----AELEQAH-RRRRELATQHQHDLAAE------AEQPPRAQLQAAQALASPGQTHQRRVKVLEEQVASLKEQLDQEA
QQ------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Myotis_lucifugus_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------------------VFQRL
EDTVLSPTASK---------------------------------------EDRALTVRGEGWQASPTPLPARIREIVASS
LGEEPPQG-VREPP-------GASAQVQEESELLQGELSRLEDLLAQVGAERDELASRYH--------------------
--------------------------------------------------MVSERLRN--------------SCDPWPGS
SILCAFQGVRQAAARGRFGYKVRGV-GSGGNPPPPCPQGLSSLPQHPRLCSESAHLLQAQLQTTEARLRRSELEHS----
-----------------------------------------------------------------------VDLEEALGR
LEAAEQRSTGLSQVNTLLREQLEHMKKANDALAEELARTTGSVLHLRGELELREAQRWTERQTRR---SHLGVQPQDFLL
LWRQVTALRTHVAELRSASERSLTDMQAEAARTARRLHTACLNLNSNLQLSASSSAGALERQAL---QGAWLEQQLRDKV
REMLQLQGRWDTEKVALQAR----------LSEQKLLVEKLTEQNSEKERTISSLRMDVQRLESWRSGG-----------
---QLAADNLKEEVKSLRRVLNIITEVAQAD----------SRCPELAQSSSTDREKAQRPLRSPPRTSSLHWG------
------------ASPPRAHSRASPDPALRAVQAAIERRRQQEQELRLQLKSSQAVTARLREQLSERQRELRASRRLLQER
EQER----GDLLDRLEAQSQKAQHFRAASELLGREKK----------------------------ALELEMEELRGKMDV
WDMDK----------QKREAEIAELQRSLLLWTQQKEELEQQGERGRR--ELQTSQGRLEQ-------LEEKVSGLKKEL
VSAREALNAARLQRDVLESEREALHGTLARNA-----DLELLVTRLKSEGVQQRDSLAKMATLMEGLAKDKGSLTHQVLQ
SMEAQVCGAWAWRHRCVGHPPPPRQLQQEGDQLREQEQVLRQERADARERLALAEQQLEQLEG-----------------
----QADRLQRERAQLQ---------------------EQVGQVTCKKQALEEQLAQSLRDQEAQMDTLRTALQEKEALL
EERVQLLAKQEALERQGRLTAEEAAD-----LRYPGAYGQGVCAWPCLREAAVWQGAAEETWRASGRRKVLGRESSL---
-VELEQLKGAWEVQETKLEWDIGQLRRQMAQQEREAQ------LALESQALAHCEDLAR--LQREKETLSLSLTEEKKVA
ACRLEQEKE-LVAKS-------------AAKREALKEEIQSLKHERDESLLQLEHEM-----------------------
--------------------------------------------Q--QCDTVKYSLSS-------EWKDKHWVCAHSCST
LRFLRRRKKRXRKAQGTRNRATVRATAAELKALQAQFEEAISAHERETSALNHSLRKMAAERSNAGR-------------
----------------EAEQL-------------WAQLGEAQEG--------LAVLRRELQGSEDSLEGLRREVVDAHRA
LGDEALEKDMLQRSNAELQAAVCKAEQEKASFQRAKEEKEQKVLVLEEARAAAQKEAGKLRASLQEAERAQLDTCRELRE
LRSQVK--------------------------------------------------------------------------
------------------------------------------------------------------------MLETENQR
KSQEVCQLQAQCAQDSQRQQQSW------------------------REALELQRQAAEVDAAREDAQKEVLRLQQKLAE
VKERLCESHRAEQSLRAELHGATMKLQQASSVTDSLQARLDRACHRVHSLEQELARAEGARR-DAQGQLSRLWSTLCCEL
GLRAQGPSASP------------------------------------KRPGSPTKGLDG--SQGHSGRHSASP--PAR-S
RSPLRWPSPA--------------------------------------------------------------PGQQGPDM
DVASVQDALRDFMQKLRDAQQE----RDNWRAQVRHLS-SWLREVERERARAQSHVGQLKTALAQAEEGWRQAEREAGSA
QATR----ALQKEVLQRLEREH---------------LASVRTAGQEKRRLQVGTPHPRAG-------------------
------------RGK-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Strongylocentrotus_purpuratus_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------MLREQLDQATEANRSLNHEIDQLSNEVKRSQDDLDNRETEWRDEEKSFN---EYFNSEHSRLLV
LWRQIVAFRRNFAEMKSSTERDLTQMRSDVTRTSRNTQSACQNLQSASQGSETGAVMALEREKG---EKMQLESQMREKL
---KDMLDMQAKFDAEKGDLT-------TRINELTIANERYKIQVAEKENQLRQRSASAAGGDHFDSAQSEASQEAYMLP
GADGGSLRAVQEECEALHMALRDIAQAVIQDADASAADMSEFAAGQEGDVTLDVSLASPYAKSTPLRPLSPTRYNRHRSP
SPRRPVTPSRRTASPSRARSPGFPDSTYSAVQAALQKRQLQVQELKARLNSTRDQASTLKKNLEGSENERRQTERAVDAH
RD----NLSVSQRQLEEIKRDRDRLRNSLEATG----------------------------SEKSGLENLRQSLNAQIES
LNVEN----------ERLQAANSDLQRQRDHLEDEREDREKDSIRQKK--EIERSHKLLEQ-------MEGKNSNLKEDI
VTLKEALNKAVLEKDVLEQEKAEISESLARLE-VQRAELEVELNRLRTEEAGLRDSLLKMQALNEGLGQDKIELNKIIMQ
-------------------------LEAEKNRLIEDKDNIHHERAAIRDELMRVESEKVDTETEKMGLNQSLSLMEDNRT
RLEEEMSLLNREKGELG---------------------DNLSQLSRQKNSLAEELLQTRRDVERQIEAVTRIAKEKEELT
KEKAELIVQLTASERENRAQAEVIAA-----MNTDK--ESLERTLYEYQQSLAKLEAKRTQLESELQEQGVSKEGVTV--
--ELARQRKEMEIEMTRYQKDLELLNQRMVQQERDTQ------LALKQRQQAHDEDVER--LNRERESLKLAMEAEKEDL
VRKTNQEREELNGRY-------------MQEKEELTEDLMGLQRERDESLLLAEN-------------------------
--------------------------------------------DKQQSLSLAQTERNQLVEKLNSSQRDMANASMEMDR
IKREAFTRAETDKE-------AIRDVQDELKELRARFEEGT---NVRERQAKDLS-NQIKDLQKVKE-------------
------------ALLREVNEL-------------KTQLKMAEESRDG-VRRELIEAHRKIREGDEGREIQRKENMELKRQ
MNDEVREKDAINRANEELRQKVKKVETDRIQLNRNVEERTQKIAVLEESKTAIQKEAGDLRASLREVEKSRLEARRELQE
LRRQVK--------------------------------------------------------------------------
------------------------------------------------------------------------TLDTDKAK
LTKDIHDLQNRVARDDEKEEENRKEIYALKQKVMETEAERES---ARKDAQNLTRRFGDLEEELRLKE----------KD
YAMSVDEARSAERRISERLRTTENALDETKADLGDLKLKLSAAEGRVNGLESQLAQVEGAKQ-EVEFKLGSLHSTLRRTL
GIGAGGMGSSLSLASSTSPGPRSSLRDRSPSPVRARRTRSPVKGFDNTFAS-TADGFGTPIPRTGSPELQDRSASPLPTR
STSPTRMEQ------------------------------------------------------------------LVADI
DPETVRIALKDFSQQLKDTERE----RDEAFCRIRLIT-QELAENEAARHRVDQRLQQFQKSLTEAEEGKRG---ADGRL
SSAQTAL-MLQEETIRRSERDRKGMQEKINTLERSLQSAEAEKRNQSDRIAKMNQGSQR---------------------
------------MEGDKRSLRETLEASENRCTQLELKRRALEGDLQRSHLSMNDKETESQVLQ--DRIEALMRQIQDLES
KNTSLQLTVDRLSSSLARSEEGEHTLKDQLQSLSLSLNDTAMESTQKQ----EQLHHLQQAVANSEKDRRVLQERLDAAR
HGASDAKKQNHQLIERVQQGQNDLAECELRRAELEQQVRSSQQLVKQHQE------------------------------
--------------------------------------------------------------------------------
-----------SEETTMTQ-IQRFQAEKRSLKEHVTTLQKAYSNLETEKREVQRSAGRLEKDKTALKKTLDKVEREKMRH
EEAVMRATSEKGALDQSLTSLDQENIELQRQTQALQATL-----------------------------------------
--------------------------------------------------------------------------------
--AETEQQHAQRLIELTTRHRQ---ETEIE------TERLRTAQLQAERTLEARERAHRQRVKGLEEQ-NSTLKDQMHHE
VRKRQQYISMSSKTNDEIQDLRNMLSDSLHSVA-------------------------------RDPTLDPVLLEHETRK
LDESMGYSSSLRRSARGASPPTS-LSPRLAKDRNRSISPVRLGKPASTSTPGMDSKLRSSSGRTRSARGLSPSSLRGSLR
K-------------------------------------------------------------------------------
-------------------
>Capitella_teleta_CROCC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------MSTDSTDYSGSRSYKRRSGGGGWERTSRKVENLAHSLKDTN-------------------
--RNLKAVDKMLLDYKDASEQQ----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------NSVIDKLQGDVSRSRHRIRDEKARIRGSSLRGCSEEDLSRDSRRRSRMPTSPLRNY
DR--------------------------------------------------------------------AASDHEFADD
WQPTR-----------------NSVRFYDDMDTPPRLHRLHQSVRDVS-----------------------------SEQ
LRLEDDLQQEILRRHRIETDHNKTLAALLEQTKQADPALNSVEQRLQSIQDELRSERTFLRRKQDEVGKVSQELKQQPAN
--------------------------------------VVYDGRVNAVENEAQLRARLTQVETQKTAMESELERTKQRLE
QVDGNKSTLITEVNDMR---------------------RQLSRVEHERDQLGLQLEQRERDLKAQLKTRSLDEQQDGLRE
QEIKRLKQDLEEARSQLTKSASVVGD------------------YGELRRELDKSERLRSQLSDHIQVGVALF-------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Homo_sapiens_CEP250
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWR--------------------
--------------------------------------------------------------------------------
--------------------KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATG--GPIPQ--RWENVE----
----------------------------------------------------------------------EPNLDELLVR
LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLS
LWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGR----EPAQLLLLLAKTQ
ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI-------------------
----------------LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV--MVEEGDNIAQGSGH------------
----ENSLELDSSIFS-QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL
TG-----------ERDTLAGQTVDLQGEVDSLSK----------------------------ERELLQKAREELRQQLEV
LEQEA----------WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR--ERERLQEML-------MGLEAKQSESLSEL
ITLREALESSHLEGELLRQEQTEVTAALARAE-QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ
-------------------------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA
ELQADLRDIQEEKEEIQ---------------------KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV
REKAALEVRLQAVERDRQDLAEQLQG-------LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG--
--EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK------TALEQQKAAHEKEVNQ--LREKWEKERSWHQQELAKA
LESLEREKMELEM-----------------RLKEQQTEMEAIQAQREEERTQAESAL-----------------------
----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER
LRQDMKVQKL-------KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD
DSQRLVEQEVQEKLRETQE---------------YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD
MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA
EQQPGNQA------------------------------------------------------------------------
----------------QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEA
VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE
TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE
RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ
ELEKCRSVLE---------------------------------------------------------HLPMAVQEREQKL
TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR
ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE--------------HL
TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL
ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQ
RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ----------------------
-ARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR
AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI
QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK
EQEILELRETQQRNNLEALPHSHKTSPMEEQSLK-----------------------------------------LDSLE
PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE
RLHSPGATSTAELGSRGEQGVQLGEVSGVEAE---------------------------PSPDGMEKQSWRQRLEHLQQA
VARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG--QKNSDAKC---VAELQ
KEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPS
PSTTQAASR----------
>Pan_troglodytes_CEP250
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWR--------------------
--------------------------------------------------------------------------------
--------------------KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATG--GPIPQ--RWENVE----
----------------------------------------------------------------------EPNLDELLVR
LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLS
LWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGR----EPAQLLLLLAKTQ
ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEI-------------------
----------------LETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQV--MVEEGDNIAQGCGH------------
----ENSLELDSSIFS-QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL
TG-----------ERDTLAGQTVDLQGEVDSLSK----------------------------ERELLQKAREELRQQLEV
LEQEA----------WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR--ERERLQEML-------MGLEAKQSESLSEL
ITLREALESSHLEGELLRQEQTEVTAALARAE-QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ
-------------------------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA
ELQADLRDIQEEKEEIQ---------------------KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV
REKAALEVRLQAVERDRQDLAEQLQG-------LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG--
--EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK------TALEQQKAAHEEEVNQ--LREKWEKERSWHQQELAKA
LESLKREKMELEM-----------------RLKEQQTEMEAIQAQREEERTQAESAL-----------------------
----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER
LRQDMKVQKL-------KEQETTGILQTQLQEAQRELKEAAWQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD
DSQRLVEQEVQEKLRETQE---------------YNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD
MQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAA
EQQPGN--------------------------------------------------------------------------
----------------QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSLWGLEPDQNGARSLFKRGPLLTALSAEA
VASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE
TMASLQSRLRRAELQRMEAQGEQELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE
RAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ
ELEKCRSVLE---------------------------------------------------------HLPMAVQEREQKL
TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR
ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE--------------HL
TQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL
ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGQLKEQSLESQLDEAQ
RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ----------------------
-ARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALR
AESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHTRQLEEALRIQEGEI
QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK
EQEILELRETQQRNNLEALPHSHKTSPMEEQSLK-----------------------------------------LDSLE
PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE
RLHSPGATSTAELGSRGEQGVQLGEVSGVEAE---------------------------PSLAGMEKQSWRQRLEHLQQA
VAQLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRG--QKNSDAKC---VAELQ
KEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGPVLLHPS
PSTTQAASR----------
>Gorilla_gorilla_CEP250
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------------------------------MKPQSLQLVLEEQVLALQQQMAENQAASWR--------------------
--------------------------------------------------------------------------------
--------------------KLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATG--ELTVK--RWENVE----
----------------------------------------------------------------------EPNLDELLVR
LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLS
LWREVVTFRRHFLEMKSATDRDLTELKAEHVRLSGSLLTCCLRLTVGAQ-SREPNGSGRMDGR----EPAQLLLLLAKTQ
ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDHEKMIKALRETVEI-------------------
----------------LVHDPLLWKGVGHGLVDSLCFMICMQCVLTREELANSEYPRDSDNEAMRSTLGLKHPFTV----
----QRQHPSPIYSPPSPKGEDDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL
TG-----------ERDTLAAQTVDLQGEVDSLSK----------------------------ERELLQKAREELRQQLEV
LEQEA----------WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVR--ERERLHREVSLSFEMLMGLEAKQSESLSEL
ITLREALESSRLEGELLRQEQTEVTSALARAE-QSIAELSNSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ
-------------------------LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGA
ELQADLRDIQEEKEEIQ---------------------KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV
REKAALEVRLQAVERDRQDLAEQLQG-------LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG--
--EVRCLKLELDTERSQAEQERDAAARQLAQAEQEGK------TALEQQKAAHEEEVQI--CGQ--EKERSWHQQELAKA
LESLEREKMELEM-----------------RLKEQQTEMEAIQAQREEERTQAESAL-----------------------
----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER
LRQDMKVQKL-------KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD
DSQRLVEQEVQEKLRETQE---------------YNRIQKELEREKARRVLGLG--------------------------
LKELINSTSQLESRTEKMRNSR----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------LAMPFLSQDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQKEKSKWEGKQNSLESELMELHE
TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------EREQKL
TVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR
ETQRVALTHLTLDLER----------------------------------------------------------------
--------------------------------------------------ARPGADHSEAADAGTGRGR-----------
------------------------------------------------EGPKAYPRTPGAQRPAGAAAPGPAQSQLDEAQ
RALAQRDQELEALQQEQQQAQGQE-----------GALEQAHMTLKERHGELQDHKEQ----------------------
-ARRLKEELAVEGRRVQALEEVLGDLRAESREQEK---------------------------------------------
-ESQSSRHQEEAAWARAEALQEALGKVHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHTRQLEEALRIREGEI
QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEP-------------------------------------------
--------------------------------------------------------------------------------
-RLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVNSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE
RLHSPG----------------------------------------------------------MEKQSWRQRLEHLQQA
VARLEIDRSRLQRHNVQLRSTLEQ--------------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Mus_musculus_CEP250
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------METGSPGLN-MKPQSLQLVLEGQVLALQQQMAENQAASWR--------------------
--------------------------------------------------------------------------------
--------------------KLKNSQEAQKRQATLVRKLQAKVLQYRSWCQDLEKRLEATG--GLIPQ--RWESVE----
----------------------------------------------------------------------EPNLEQLLIR
LEEEQQRCESLVEVNTELRLHMEKADVVNKALQEDVEKLTVDWSRARDELVRKESQWRMEQEFFKG---YLRGEHGRLLN
LWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTCCLRLTLRAQ-SRESSGSGRTEES----EPARLLLLVAKTQ
ALEKEAHEKSQELMQLKSHGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMEI-------------------
----------------LVCG-------------------------------------------PLCCR------------
----GAKKGLAGS--------------LLFVDK-----------------------------------------------
--------------------------------------------------------------------------------
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-------------------
>Rattus_norvegicus_CEP250
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
---------------------MEKADVVNKALQEDVEKLTVDWSRARDELMRKESQWRMEQEFFKG---YLRGEHGRLLS
VWREVVTFRRHFLKMKSATDRDLTELKAEHARLSGSLLTCCLRLTLRAQ-SRDSSGSGRSDES----EPAQLLLLVAKTQ
ALEKEAHEKSQELMQLKSQGDLEKAELQDRVTELSALLTQSQKQNKDYEEMVKALRGTMEI-------------------
----------------LETNHAELMEHEASLSRNAQEEKLSLQHVIKDITQALASVEEEDTVTQTPGS------------
----ENSLQSDYNDLS-QFDSQDPNKALTLVHSVLTRRQQAVQDLRQQLSGCQEAMSFLQQQHNQWEEEGKALRERLQKL
TG-----------ERDALAGQTVDLQGEVDSLSK----------------------------ERELLQTARGELQQQLEV
LEQEA----------WRLRRVNVELQLQGDSAQGEKLEQQEELHLAVR--ERERLQETL-------VGLEAKQSESLSEL
IALREALESSRLAGELLKQEQEEVAAALARAE-QSIVELSSSENSLKAEVADLRAAAVKLGALNEALALDKVALNQQLLQ
-------------------------LEQENQSMCSRVEAAEQLRSALQVDLAEAERSREALWEEKTHLETQLRKAEETGA
ELQAELRGAREEKEELK---------------------EKLNEAHHQQEAATAQLQQLHQDAERQEEALARAGQEKEALV
RERAALEVRLQAVERDRQDLAEQVLG-------LRSAKEQLEGNLFEAQQQNSVIQVTKSQLEVQIQTIIQAKEVIQG--
--EVKCLKLELDTERSHAEQERDAVARQLAQAEQEGQ------AALERQKVAHEEEVNR--LQEKWEKERALLQQKLDKT
LETLERERTELEM-----------------KLREQHTETEALRAQREEERTQADSAL-----------------------
----------------------------------------------YQMQLETEKERVSLLETLLQTQKELADASQQLER
LRQDMKVQKL-------KEQETTGMLQAQLRGAQQELKEAIQQHRDDLAAFQK-------DKIDLQKQVEDLTSQLVTHN
DSQRLVKQEIEEKVREAQE---------------CSRIQKELEKEKASLTLSLVEKEKRLLVLQEADSVRQRELVSLRQD
IQEAQEGQRELGVQVELLRQEVKEKEADFVAREAQLLEELEASRIAERQVRASLWAQEAKAAQLQLQLRSTEAQLEALVA
EQQPEN--------------------------------------------------------------------------
----------------QAQAQLRSLYSVLQQALGSACERRPELRGGGDSVPTPWGSDPDQNGASRLLKRGPLLTALSAEA
VALALQKLHQDLWKAQQARDDLRDQVQKLVQRLTDTEAQKSQVHSELQDLQRQLSQSQEEKSKWEGKQNSLESELRDLHE
TMASLQSRLRQAELQKMEAQNDRELLQASKEKLSAQVEHLQACVTEARAQASAAGVLEEDLRTARSALKLKNEEIESERE
RAQALQEQGELKVAQGKALQENLTLLAQTLSNREREVETLQAEVQELEKQREMQKAALELLSLDLKKRSREVDLQQEQIQ
ELEQCRSVLE---------------------------------------------------------HLPMAVQEREQKL
SVQRDQIRELENDREAQRTALEHQLLDLEQKAQVIESQRGQIQDLKKQLGTLECLALELEESHRKVEGQQKVITELEGQR
ELQRVALTHLTLDLEERSQELQTQSSQLHELENHSTRLAKELQERDQEVMSQRQQIEELQKQKE--------------QL
TQDLERKGQELVLQKERIQVLEDQRTLQTKILEEDLEQIKHSLRERGQELASQWQLMQERAEDGKSPSKAQRGSLEHLKL
ILRDKEKEVECQQERIQELQEHMGQLEQQLQGLHRKVGETSLLLTHREQETATLQQRLQEAKEQGELREQVLQGQLEEAQ
RALAQRDHELEALRQEQQQTRGQEESMKQKTSALQAALEQAHVTLKERQGELEEHRGQ----------------------
-VQRLQEELIVEGRQVRALEEVLGDLRAESREHEKTVLALQQRCAEQAQEHEAEARTLQDSWLQAQATLAEQEQELEALR
AENQYSRQQEEAAFGQAEALQEALSKAQATLQEKEQRLLEQAELSCTLEASTATLQATLDTCQARARQLEEALRVREGEI
QTQALQHQEAMQHLQQELCQKEEDLRQQDEQRQLLEKAVAQRSQENGIQEKQSLEQEKEEE-TRGLLESLKELQLTVAQK
EEEILMLREAQQRQNQEASSPSHRSFPAEKPSLQ-----------------------------------------L----
LLAQQDLERLQNALRQTEAREIEWREKAQGLALSLAQSKASISSLQEIAMFLQASVLERESEQQRLQEELVLSRQALEEQ
QSRGPHSSSRADQGPKAGQDTEPGE--VIEAE---------------------------PSPGVGEKEQLRQRLERLQQA
VAELEVDRSKLQCHNAQLRTTLEQVERERRKLKRDSLRASRAGSLEARETMNSSPTQQDGRGSQRGSSDSML---MVELQ
REVALLRAQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLTVAQAPEATVLEAETKKLDESLNQSLTSPAP-FLHPS
LDTTQNTHR----------
>Canis_familiaris_CEP250
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------METRGPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWR--------------------
--------------------------------------------------------------------------------
--------------------KLKNSQEAQQRQATLVRKLQAKVLQYRTWCQELEKQLEATG--GPTPQ--RWESME----
----------------------------------------------------------------------EPDLEQLLVR
LEEEQQRCESLAEVNTQLRLHMEKADMVNKALREDVENLTVDWSRARDELRRKESQWQMEQEFFKG---YLKGEHGRLLG
LWREVVTFRRHFLEMKSATDRDLTELKAEHVKLSGSLLTCCLRLTVGTQ-SRESDGSGRRDGS----EPTQLLLLLTKTQ
ELEKEAHERSQELIQLKSRGDLEKAELQDQVTELSALLIQARKQNEEYEKMLGALRETVEI-------------------
----------------LETNHAELMEHEVSLSKNAQEEKLSLQQVIRDITQV--MVEEGDSMTQGCGR------------
----DSSLELDPSGLSSQFDSQDPDKALTLVRSVVTQRRQAVQDLRQQLSACQEAMSSLRQQHNQWEEEGEALRQRLQKL
TG-----------ERDTLAGQTSDLQGEVESLSK----------------------------ERELLQKTREELQQQLEV
LEQEA----------WRLRRTNMELQLQGDSVQGEKEEQQEELHLAVR--ERERLQETL-------ASLEAKQSESLSEL
IILREALESCHLEGELLRQEQTEVTAALARAE-QSVAELSSSENSLKAEVADLRAATIKLSALNEALALDKVGLNQQLLQ
-------------------------LEQENQSVCHRMEATEQARNALQLGLAEAERSREALQEKNTHLEAQLQKAEERGA
ELQADLRAIQDEKEEIQ---------------------EKLSEARHQQEAALAQLDQLRQETKRQEEVLAREVQEKEALV
RERAALEVRLQAVERDRQDLAEQLLG-------LSSAKEQLESTLFEAQQQNSLVEVTKGQLEVQIQTVIRAKEVIQG--
--EVRCLKLELDSERNQAEQERETAARRLAQAEQEGQ------TALQQQKSAHEEEVNR--LQEKWEKERSWHQQELDKA
LESLEKEKMELET-----------------RLREQQAEAEAIRTQREEERAEAESAL-----------------------
----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER
LRQDMKVQKL-------KEQETTQILQAQLREARGELEQAAQQNRDDLVAVQEECGALLQAKMDLQKRVEELKSQLVSRD
DSRRLVEQEVQEKLREAQE---------------YSRIQKELEREKASLIQSLMEKEQRLLVLQEADSVRQQELSSLRQD
MQESQEGQKELSTQVELLKQEVKEKEADFLAQEAQLLEELETSQVTEQRLRASLRALEAKAAQVQLRLRSTENQLAALVA
EQQPGH--------------------------------------------------------------------------
----------------QAQAQLASLCSVLQQALGFACESRPELRGGGDSAS-LWGPEPDQNGTGILLKRGPLLTALSAEA
VASALQKLHQDLWKTQQARDDLREQALKLEQRLTDTEAEKSQVCTELQDLQRQLSQNQEEKSKWEGKQISLESELTELHG
TVASLQSRLQQAELQGLEAQ------------------------------------------------------------
--------------------------------------------------------------------------------
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-------------------------------------------------------------------DELELTRQALEKE
QLLSSSSTSRAEQRPRE-------EVSEVEAE---------------------------PSLGLEERQLWGQRLEYLQQA
VAQLEIDRSRLQHHNVQLRATLEQVERERRKLKRESMRVSRTGGLEVKEAAASSPTQQDGRGGQKGSSDDKQ---MAELQ
KEVAMLRGQLALERKQRQDYIARSVQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRKLDESLTQSLTSPGPALLCPS
PSTIQAISR----------
>Felis_catus_CEP250
--------------------------------------------------------------------------------
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--------------------METGGPGSNNMKPQSLQLVLEKQVLALQQQMAENQAISWR--------------------
--------------------------------------------------------------------------------
--------------------KLKSSQEAQQRQAALVRKLQAKVLQYRTWCQELEKRLEASGAKGPISP--RWESVE----
----------------------------------------------------------------------EPSLEQLLVR
LEEEQQRCESLAEVNTQLRLHMEKADMVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKG---YLKGEHGRLLG
LWREVVTFRRHFLEMKSATDRDLTELKAEHVRLSGSLLTCCLRLTVGAR-SGEPDGSGRLDGS----ESTQLLLLLTKTQ
KLEKEVHERSQELIQLKSQGDLEKAGLQDRVTELSVLLTQAQKQNEDYEKMLKALREAMEI-------------------
----------------LEKNHAELMDHEASLSRNAQEEKLSLQQVIRDITQV--MVEEGDGMTPGCGH------------
----ESSLELDPSGDSSQFDSQDPGKALTLVRSVVTRRRQAVQDLRQQLSGCQEAVSSLRRQHDQWEEEVKALRQRLQKL
TG-----------ERDTLAGQTTDLQGEVESLSK----------------------------ERELLQKTREELQQQLEV
LEQEA----------WRLRRTNMELQLQGDSAQGEKEEQQEELHLAVR--ERKRLQETL-------AGLEAKQSESLSEL
ITLREALESSHLERELLRQEQTEVTAALARAE-RCVAELSSSENSLKAEVADLRAAAAKLSALNEALALDKVGLNQQLLQ
-------------------------LEQENQSMCSRMEAAEQARSTLQLGLAEAERSRDALQEKNTHLEVQLQKAEETGA
ELRADLRGIQEEKEEIQ---------------------EKLSEAHHQQEAAFAQLEQLHQEMKRQDEVLAREVQEKEALV
RERAGLEVRLQAVERDRQDLSEQLLG-------LSSAKEQLESNLFEAQQQNSLIEVTKGQLEIQIQTVTRAKEVIQG--
--EVRCLKLELDTERSRAEQERENAARQLAQAEQEGH------TALQQQKSAHEEEVNR--LQEKWEKERSRHQQELGKA
LESLEREKMELEM-----------------RLTEQQAETEAIRTQREEERAEAESAL-----------------------
----------------------------------------------CQMQLETEKERVSLLETLLQTQKELAEASQQLER
LRQDMKVQKL-------KEQETTELLQTQLRDARQELEQAAQRDRGDLAGLREECRALLQAKTDLQEQVEDLKSQLVSKD
DSQRLVEQEIKEKLREAQE---------------YSQIQKELESEKASLIQSLVEKEQRLLVLQEADSVRQQELSSLRQD
LQEAQGGQKELSAQVELLKQEVKEKEADFLAQEAQLLEELEASRVTEQQLRASLRALETKAAQVQLRLRSTENQLAALAA
EQQPGQ--------------------------------------------------------------------------
----------------QAQAQLASLCSVLQQALGSACENRPELHGGGDSAS-LGAPEPDQNGARILFKRGPLLTALSAEA
VASALHKLHQDLWKTQQARDDLREQAQKLEQRLTDTEAEKSQVCTELQHLQRKLSQNQEEKSKWEGKQISLECELTELHE
TVASLQSRLWQAELQGIEAQNERELLQAAKENLMAQVERLQASVAEARAQASAAGALEEDLRNARSALKLKSKEAETERE
RAQALQEQGELKVAHGKALQENLAILAQTLSKREGEVETLRGNIQELEKQREMQKAALEVLSLDLKKRNQEVDVQQEQIQ
ELEKCRSVLE---------------------------------------------------------HLPMAVQEQEQKL
AVQREQIKELEKDRETQRNILEHQLLELEKKAQVIESQKGQIQDLKKQLVTLECLALELEENHHKMECQQKAIEELEDQR
EVQRLALTHLTLDLEERSQELQAQSSQIHELESRSTLLARELQDKDQELQSQREQIEELQRQKE--------------HL
TQDLERRDQDMVLQRERIQVLEDQRTLQTKILEEDLGQIKLSLRERGRELASQRPLMQERAEEGKGQSKAQRGSLEHMKL
ILRDKEKEVECQQERIQELKEHKGHLEQQLQGLHRKVGETSLLLTQREQELVVLQRHLQEAREQGQLKEQSLQGHLEETQ
RALAQRDQELEALQQQQQQVQGQEESMKEKASTLQRALEQAHAVLKERQGELEDHKEH----------------------
-VRRLREELVVEGQRVQALEEVLGDLRAESREQEEALLALRQQCAERAQEHEVEIRGLQDSLLQAEAMLKERGRELEAVQ
ADGRSSQHREETARARAEALQEALSEAQATLQEKEQRLLGQAELSRNLEASTATLQAALDSCQAQARQLEEALRRREGEI
RDRDLRHQEAVQQLQRALAQRDDELSHQKRQGQLLEQSLAQRDRED--QGKQGEGREREEEEMRGLRESLRELQLTLAQK
EEEILGLREAQQRKNLEDSPHSHTASPAEEPSTQ-----------------------------------------FDALG
PRLQQELERLQAALRQTEAREIEWREKAQDLALSLAQSKASVSNLQEVAMLLQASVLERDSERQRLQDELELTRQALEKE
RLFSPSLTSRAERGPREEVGVQLEEVPGVEAE---------------------------PSPGMEEKQLWGQRLEQLQQA
VAQLEIDRSRLQRHNVQLRATLEQVERERRRLKRDSMRALRTGILEVSEA-----TQQDARGGQKGTSDAKH---MAELQ
KEVALLRAQLALERKQRQDYIARSTQTSRELAGLHHSLSHSLLAVAQTPEATVLEAETRKLDESLTQSLTSPGPVLLCPS
P--TQATSR----------
>Myotis_lucifugus_CEP250
--------------------------------------------------------------------------------
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--------------------METGGPGLNNMKPQSLQLVLEDQVLALQQQMAENQAASWR--------------------
--------------------------------------------------------------------------------
--------------------KLKSSQEAQQRQAVLVRKLQAKVLQYRSWCQELEKQLEATG--GPIPQ--MWDSVK----
----------------------------------------------------------------------EPNLEQLLMR
LEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELIRKESQWRMEQEFFKG---YLKGEHGRLLS
LWREVVTFRRHFLEMKSATDRDLTELKAEHVKLSGSLLTCCLRLTVGTQ-SRESDGSGRLDGS----APAQLLLQLAKTQ
ELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMVKALRETMEI-------------------
----------------LETNHAELMEHEASLSRNAQEEKLSLQQVIKDITQV--MVDEGDNMSQGSGH------------
----ESTLELDYSDFSSQFDSQDPDKAVTLVRSVLTQRRQAVQDLRQQLSGCQEAVSFLQQQHNQWEEEGEALRQRLQKL
TG-----------ERDTLAGQTVDLQGEVDSLSK----------------------------ERALLQETREELQQQLAV
LEQEA----------WRLRRTNMELQLQGDSAQGEKEEQQEELHLAVR--ERQRLQEML-------AGLEAKQSESLSEL
ITLRENLESSRLEGELLRQEQTEVTAALARAE-QSIAELSSSENSLKAEVADLRAAAAKLSALNEALALDKVALNQQLLQ
-------------------------LEQENQSVCSRMEAAEQARNTLQVGLAEVERSREALWEKNTHLEAQLQKAEETGA
QLQADLRSIQEEKEELQ---------------------EKLSEARHQQEAASAQLEQLHQEAKRQEEVLAREVQEKEALV
REKAALEVRLQAGERDRQDLSDQLLG-------LSSAKEFLESSLFEAQQQNSLIEVTKGQLEVQIQTVTQAKEVIQG--
--EVRCLKLELDTERNRAEQERDTAARQLAQAEQEGQ------TALQQLNSAHEEEVNR--LQEKLEKECSRHQQELDKA
LETLEKEKMELEM-----------------RLREQQAETEALRTQKEEERAKAESAL-----------------------
----------------------------------------------CQMQLETEKERVSLLETLLQTQKELADASQQLER
LRQDMKVQKL-------KEQETIGMLQTQLREARRELEQAAQQHRDDLTALQGESSSLLQDKIDLQKQVEDLKSQLVSKD
DSRRLVEQEIQEKRREAQE---------------CSRIQKELERDKASLTLSLVEKEQRLLVLEEADSVRQQELRSLHQD
LQEAQGGQKELSAQVELLKQEVKEKEANFLAQEAQLLEELEASRVTEQQLRASLWAQEAKEAQLQLRLRSMESQLEALAA
EQQPGH--------------------------------------------------------------------------
----------------HAQAQLASLCSVLQQALGSVCESRPELSGGGDSAPSFWGPEPDQNGTRILFKRGPLLTALSAEA
VASALHKLHQDLRKTQQARDDLRNQAQKLKQHLTDTEAEKSQVQTELRDLQRQLSQNQEEKSKWEEKQKSLESELMELHE
TVASLQSRLRRAELQGMEAQNERQLLQAAKENLTAQVQHLQASVTEARAQASAAGVLEEDLRTARSALKLKNEEVESERE
RAQALREQGELKVAQGKALQENLAILAQALSEREGEVEALQEKIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ
ELERCRSVLE---------------------------------------------------------HLPMAVQEREQKL
TVQREQIKELEKDQETQRNVVEHQLLELEKRDQVIESQKGQIQDLKKQLVTLECLALELEENHRKVECQQKAIEELESQR
EVQRVALTHLTLDLEERSQELQVLSSQVHELESHSSLLAGELQEKDQEVKSQREQIEELQRQKE--------------RL
TQDLQRRDQEMVLQKERIQVLEDQRTLQTKILEEDLEQIKLSLRERGRELASQRQLMQERAEEGKGQNKAQRGSLEHMKL
ILRDKEKEVECQQERIQELQEHKGQLEQQLQGLHRKVGETSLLLTQREQEIVVLQQHLQEAREQGELKEKSLQGQLEEAQ
RALAQRDQELEALQQQQQQAQGQEEVVKEKAGTLQRALEQAHMTLRERQGELEDQREH----------------------
-VQRLQEELTVEGQRAQALEEVLGDLRAEFQKQEKTLLALQQQCAERAQEHEAEAKALQDSWLQAEAMLKQRDQELEALR
ADSQSSQHQEEAARGQVEALQEALSKAQAALQEKEQHLLGQAELSRSLEASTATLQAALDSCQAQARQLEEVLRKREGEI
QDRDLRHQAAVQELQQALAQRDGELRHQRKQRQLLEKSLAQR-----LQE-----DEREEE-MRGLYESLRELQLTLAQR
EEEILELREQRKNLEASAHSRKAS--PVEEPSTK-----------------------------------------LDSLG
PRLQQELERLQAVLRQTEAREIEWREKAQDLALSLAQSKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRQALEKE
RLHSPGPTSRTEQGPRGEAGGQLGQVSGGEAE---------------------------PSAGTQEKQPWEQRLEHLQQA
VAQLEVDRSRLQHHNIQLRTTLEQVERERRKLKREFLRTSRSGVLETSEATASSPTPQVYLFIDCSLSCSLP---LGFPA
QQVALLRAQLALERKQKQDYIARSVQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRKLDESLTQSLTSPGPVLLCPS
PSPSPRASQ----------
>Monodelphis_domestica_CEP250
--------------------------------------------------------------------------------
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--------------------MEARDQGHN-MKPQPLNMVLEKQILALQQQMAENQAASWH--------------------
--------------------------------------------------------------------------------
--------------------KLKISQEAQQRQAVLVRKLQAKVLQYRNWCQELEKRLEDMG--GPMPK--RWTSAE----
----------------------------------------------------------------------EPRLEQLLIR
LEEEHQRSEGLVKVNTQLQEHLEEADVVNKALQEDVGKLTVDWSQAQDELARRQSDWQMEREFFKG---YLKGEHGRLLS
LWREVVTFRRHFLEMKTATDRDLAELKAEQVKISGSLLTSCLHLSLELQ-SREAQGSGRLAGN----E-QVHLQLVAKTQ
ELEKEIHKRSQELILLKARGNMEKTELQDRVTELSALLAQSKKQNEEQEKMLKALKDTMDI-------------------
----------------LETNRSELMEHEASLSRNSQKEKLSLQQVIKDITQV--VVDDEDSENQSFGL------------
----ESSLEMESSIFC-QLRSEDPDKAVTLVRSILAKKHQAVQGLRQQLSTCQEAVSFWQHQHTQWEEEGEALRQRLQKL
TG-----------ERDVLAGQTQGLQGEVDSLNR----------------------------DRGHLEKAREELQQQLEI
LEQEA----------WRLRRLNTELQLQGDLAQGEKVEQEEELQQAVR--ERDCLQETL-------KGLEARQSSSLSEL
ISLKEALEKSHLEGELLNQERAEMARALAKAE-QSIAELTGTERTLKAEVADLRDAAAKLSALNEALALDKVELNQQLLQ
-------------------------LEQENQSVHGKVEASEKARSAVQMELDESEQRKEALLEEKACLEMQLQKSKDAEA
ELQGDLSREREEKIETQ---------------------EKLNEAQRQLEVATTELEQLHQETTRQELLREKVIQEKEILV
RDKAALEVHLKALERDQQDLSEQLLE-------LSSAKELLETNLFEAQQQGSLMEITKEQLMMQIQTVTQAKEVIQG--
--EVKCLQMELEAQRQQAEQEQDTAAKHRDQMEQESQ------AALQQQRATYEEELHL--LQEE-RMDQIKHRQELEAT
LEQMKREKVDLEETC-------------EKKLRELQEESEAALAQRIKDHAQAESNR-----------------------
----------------------------------------------CQMQLEMEKERMSLLETLLKTQNELADAGHQLEQ
LRQDIKDQKL-------KEQENMEDLWAQLQEAQKTLMETRRKHHNDLAALEEEKSILLQQKENLEQQVQDLKAQLVTSE
DSCRLAEHEAQKHLQEVQQ---------------CTHIQEEREQEKASLVQSLAEKEQRLLILQEADSLQQQELSSLRQE
VKEAQEEQEQLSAQVLFLKEEMQKKEASLLDQEI-LLEKLGASKKTEQQLRASLWAQEAKAAQLQLQLCSVESQVGALIL
EQQNGH--------------------------------------------------------------------------
----------------QAQAQLMGLYSILQQAFGSAIESRPELSGAGDASPLSWSPRTLEPGQENFLKNQIAVTNFTTED
VASLLHKLQRDLWQARHTRDDMKCQVEKLEQHLSQAEAERNQFSTEIQELQSLLSQNQKEKLKWEGEQSSLETELAVLQE
RVASLQNSLKRSEQQRTEAQNEQATLWAANEKLVSEVEHLQASVAVTKAQANAREALEAELRATHSALRMKNEEAESERE
KAEALR----KKLAQGKALQENVDLLTSTLSKREKELEALQGVIQELEKQRESQMVMQEHLSLNLKKRSQELESRQEQIQ
ELEKQKAGLE---------------------------------------------------------HLPVALEQKKKQI
RLQREQIKELEGKQETQGNILEHQALDLQKKTQTLESQREHIQDLENQLVTLEHLVLEVKKNHQEIESQKKKIEDLENQR
EMQRVTLTHLTLDLEEKSQEIQSQNKKIKELEKHNALLTVNLEERCQEMKSYRDQVEELKKQKD--------------QL
TWDLEKKNQELVLQEEKILVLEDQRMLQNRVLEEDFEQMKLALREKDQEIESQRQLMIEREEEEKGQAKAQRSSLEHMKL
ILRDKEKEVEYQRERIHMFQQYGEQREEQLQGLRRKIGEMTLLLTQKDQELETQQQHIRRVQERRESRERALQDQLERVQ
EALQTKVQDLEALQQKAQLQQESQE---EQMSTLQAALEQARAALEEHEEAIEAHKEQ----------------------
-NQKVQQQQTAAELQVQALEELLGDLRAEFQEQEKVLETLRQQCTEQGHEQETQAWH-----------------------
-QHTEARQWEKTTAGQVQALKEALRVAQASLQKKDQELLQQAELSQRLEGSAAALQVALDSCQTQARHLEEALREREEEI
REQQLQHQEMVQQLQLALAQRDGELRQLKEKGQQQEAALNQSD-------------KGEEKEEKVLRQNLRHLQLTLSRK
EFQLQETHRRHGQESYYESHSPEKMEDGEEEEVYGTGTM--------------------------EKMSLREISPVSMEE
AKLQEELERVKNVLRQTEAREIEWQEKAQALAFSLAESEASICNLREAALFLQAKTAEQNTEQLQLEEQLQLTRQALEDE
QSHNRGSAWRTEPEIQGDEGTSQRKATGPEDDG--------------------------SCTELEKTQQWQQRLKYLLHA
MASLEHERNRLQRHNFQLRVTLEQVERERRKLKRNFNRMTHTTPPLPRETTALTPGQKQEKGGQENSSELKH---VAELQ
RQVTALQTQLALERQQKQDYISRCVQTSRELTDLHHNLSNSLWAVARAPEANILEAEARKLDKSLTQSLTSSAPSPPCCT
PRSAQATSRS---------
>Gallus_gallus_CEP250
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---------------------------------------------MAAREAARGQACLRR--------------------
--------------------------------------------------------------------------------
--------------------RLHGAEEAQQQQAVLVRKLQEKLLQYRSWCRELEQRLEAGGVSVQGSLSYRWETTE----
----------------------------------------------------------------------DHSLEKALLQ
LEEEQQRCENLAEVNTLLREHLDKANEVNLALKEDVGKLTADWMRAREELELKESEWRSEREFYDS---YLRGEHNRLLS
LWRQVLTFRRHFLEMKTATDRDLSELKAEQMRLSGSILVSCFRLNSGVQ-LWESVTLGRPVLK----DQAQQQVEREINQ
EALEVMCLQVDEDLEKKEL--------QDRVMELSALLVQSQKQNEEKEKTVKTLNDTVEM-------------------
----------------LEASRLEV-EYEASLTKNAKEENLALQKLIKEITEVVLDDSDSTVGIVQ---------------
--------RPESSNVLSCLSSLDAEHAFVLVQETLARRQKAIQALKEELSTRQDSISFLQHQHRQQEEKCKKLQQRLEQL
EE-----------ENKMSNSHQQHLKSLVLALKC----------------------------DCENLEKIRGELQQKLEL
SEQEA----------SRLRQSNTELQLKEDSAQGEKVEQQLAMERAHH--DHELVLKDL-------AALEEKHSLLQNEL
VAAREKLEESHLQRDLLKQEKHELTVALEKAE-KSVAALTGAQNKLNSEIADLHTAAAKMSSINEALALDKVELNKLVLQ
-------------------------LEQENELLSDKVNEMERAKVSEQEKITLYKRTNEELCAEKSHLEKLLKKAEEQQE
ELQMQLRILAEEKEETL---------------------EKLNQVYRQQESASSGLEQLRQQSSRQEDAVAKVSKEKEFLV
HEKAALEVRLAAVERDRQGLSEQLAE-------ARSVKDTLESSLFEAQQQLSHLEITKSQLEIQLHTVVQAKEVIQG--
--EVKCLQYELETERCLMKQEQKNMAQRLIQIEEQHN------NTLKLQQTDHEVEINK--LLQDLASEREGRQLELQEM
LELWEKEKAEAEGQH-------------EKKLFHMKEKVATMQAQQEEERTRVESAN-----------------------
----------------------------------------------QEILTEKENEKKALLETLLQTQGELTEACHQLEQ
LRQEVKEQQE-------YEQNITEKLQAELQETHCKIKMVENMHKEEMENIKEEKNILLQQRDDLQKQVEELTSQLAASE
ESHQAIGHKAQQELSEAQE---------------LSRQKVLEVVHLQKILEEERGQWEEVEHQNKELQ------------
--------------------------------------------------------------------------------
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--------------------------VCLQSLEGERSRWEEVERHNTEFQASLKALESERERLSLSLEQKELSLKTLEEN
NLVQQNEVSKLHSAIQQAQQLHSDHRREIQELNNQVQTLQEVVLEKEASLAAREKQLLQDLEESRAGERCLRDSLHVLEA
EMAELHLRLCSTENRAKALATECQQANNAHCEAQSQLDKLHLVLHHVLCD------STDKSRDLVAWSSGKSGRDENYVE
CLGMKENMEGRDGSSQSY--------------------------------------------------------------
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>Anolis_carolinensis_CEP250
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------ME-GDQAAHSMKMESAHLS-DDQLVSVHQQMIESQASYRN--------------------
--------------------------------------------------------------------------------
--------------------KLQNSQEAQHRQAILVQKLQGKVLQYRNWCRDLEQRLEASR-ASYSL---RQDNKK----
----------------------------------------------------------------------DHSLEKALIQ
LEEEQQRCQNLAGVNILLRDHLDKANEVNGALREDVSKLTADWTKARDELEYKESEWHKERKFFES---YMRAEHDRIIG
IWRQVVTLHRYFLEMKTATDRDLSELKVEQMRLSGSILISCFQLSSDTR-LLEMSNLESSVLKGSLQQQQQQLYLKPEKT
DMEKEIYQQTQAIMNLRVKGDLAREDLQSRVIELTALLEQSQKENEEKEKTVKTLRDTLEK-------------------
----------------SNHLELEY-EQEQSRSKTVNEEILSLRHVIKEITEAVLNGNDATVGKPQVEQS-----------
-------AELGHS---LQLDPGGLDGTLLLVREALMKRSNEVQHLRQQLLASQNSITSLEKQQEQQEEHSRFQGQRLEQL
EK-----------ERETFTSQIQHQQSTIETYSR----------------------------DYATLEKSRTELQQHLEV
LEQEV----------WHLRQNNTELQLKGDMVNGEKEEQQQELQRMMR--EREYIQEDR-------NALEERHSSLKNEL
IALREALEKSHLDGELMKQEKYELASALEQTE-QSLAQLTSAHNKLKAETADLQGATAKMSALNEALALDKVGLHQIILK
-------------------------MEQESQMLSDNVDRLEKMKSLSQKQLKQAEQTNEELCTEKIRLEKLLQKAEELQE
GLQDELKMLKEEQKETY---------------------EKLSQVHHQHEKSISSLEQAHQESNRLGEMYAKVSKEKEKLM
CEKATLEVRLGAVEREKSALTEQVTE-------LRSVKDLLESSLFQAQQQVSQLEVAKGQLEMKVHAISQAKEVIQG--
--EVKCLRIELEAEKSRIEQENEERVQLLSQAEQKHQ------ETLSHRQIVHKEEMNA--VFQELEGERERHRVELEEA
LKRSAKEKEESESTC-------------EQKLLELQKNITAIQTRMEDELFKAQNAK-----------------------
----------------------------------------------QELLFEKENERKSLLDELLQTKDKLTSTCQQLEY
FRQEIKKHQE-------EAQVTVQGLEADLKDAQHRMKTLEKKHKEEIKSLKEEINILLQQRDALRSQVQELESQLLIAK
DSCQSISQEAQHHLREGQE---------------LSKQKELEIAHLRKMLEAERKRCEEISHQSIELQSQKEEMEHRNTE
LQAMLQNQWEAEKHLNRELQRKQEEVQRQCATLQALEREQNLWVEADRQNSEQHNVLQRQLEEAKFQNKQLQTQKREADL
QNAKLLHQKEELECQNAQLKDALQSQREEAECESTILQSHWE------------EAQQRYSELQNWKEKIEDENAELQAL
LSHQREKMESQNMELQSKQKEIEHQNIVLQKMKEERSHWEEVEDQNSELKAALQTMEQKRASLALSLKETEDRAKKLQES
DDAHKDEIAKLSTALQLTEQLLAEYRKEMQELNNEIQSLKQKTAEKEAALVAQQEQLIQDVEESHTSEQRLKDSVQVLEA
EVSTLRQSLRSTESRAEALASECQRACSARWEAQSQLSKLHSVLQYMLCNGLEVKVEHGGHGDNNIWNSLSLRTEQDKLI
RPALSQSKDFSTELTVERVTEAIQKLRKDLWQSRLERDEVRNNMEKLKQQLIEKEGERDRISAKAQELQKWFNESQEEKN
KAEGKRGSLESALKTEVIAFKEENVTLRRRLITLEKTLESTEKQRKDMLDERDSLQMAKDKLSWELDLLRESIRASEIQT
NAMEKINQSLEQELQTALSALKTKNEELETQQKKLATLHQEAEIGKTLQENVDRLTASLEKKEEEIKFQLQQIKDLERHR
EVQKTTMEHLAESLEKRTQETECQKNQIEEVKKQEKMQKADLERLNLELEKSLQIMQSQQEKIQKLEDLTQTQSTILKSL
TLDLEAKVKETQIKEEKIQILEKNESSQIGSLLKELGDLKMQLTEKDWELASQKQLLQECEEQGKKQEKCLHTRLEHMKA
ILMDKEREVASREEQIAGFQQHEAQRDSHLCDLNEKVKELAFTVAQRDEELESQRQQIREMEGEMETELKTLRELTAKTQ
LSLKERNIELEFQRKHAEEVERQIKILLGDVQISTAVLNLEDNNAEFQKDQKEQLKKQTVLNMLEQLRVLLIRKEREIKS
LKEQQDEHKEENEKTVREMQTNLQQALENKEVQLQCLKEENRQLHQLEEKAAAQTKSVMENLEFTRTSLHDREKEIQSLK
GHIREISRQKEVEQNKAVSLLNDLNKIKQSRTEKENELLRQVEHIRTYQVKLEATQAELQACQTRVNELQSVIKQKEEEN
ERDFKRLRHKHEPVQENDKHPGENEEYLEEKQRKKGEEMDAQNKQEKIKDEMKMLQENIQQLQHLLKKKDDEVEWQKRKV
EELKERVKSKEKELLISSEHLKEIVSFLNLQDNEDDNLQSHIQKLHMWKELEIVRSKALQEKDQWLTRQKEKIQQLEDEK
KVKKQELDHVTAILKKTESGEIEWREKAQRLDLSLAQSEEALRALREEMTIMQNMVSERDRDRHNLQEQLDTAFRTLEEE
RTATKALVGDVDQFISEKHLPEILGKEGEEAMRKGG-----------------------KLSWVDERRFLCRRLQLLQQA
VARLENDYRVLEQHNTQLREALKQVEHERRRLKRSCGDLSLSFGLS---QINAGPLKIPSIEKEETQVLHKE---LEKLQ
KQVFVLQKQLSLQKKQKQDYIDSCARTNHELSGLHQELSDSLAAVAKEPEATVLALETQKLDETLNYSLSLASGSCNGFF
AGKHLISSTPKRLQQKDSK
>Ciona_intestinalis_CEP250
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----------------MLREQLVSANDSNAALADDLRKVTDDWNDVKQELKTKESEWREEQENFS---SYFGDEHSRLLA
LWRAVVQIRRGFGDLKSNTQRDLAQAINDVQRGARQLHASCLNLNANQSVQDTSAKVSLEKERG---EKGDVEEQLRRKV
---KEMLSMQSDFDTEKARLN-------GRINELTVAYDRAKSQLSDKDRTIDDLRTP----------------------
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>Drosophila_melanogaster_CEP250
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-----------------------------------------------------------------MQAYRDNFKQTPCPS
AVDLQAAG------------PAHQSATASRLPFSR--SQRGRDPSASGASVSASVAGGLTP-------------------
-----------------------------------------------RMMSPGPPGAGGGGGGGVSGGGSGDPSALLRQN
QELRQRLADESHS----YRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKLTTGPTNQVL
CSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAG--------------------------------AAELCRK
LEEEHQRCEQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAFK---DYYNSEHNRLLK
MWREVVAVKRSFKEMQTAMKAEVAKMGQEINCVGKDINGSNATVAFAVQQAKRAADDELKQSQR---SND----ELQNQL
ATLKVQYESARHEIMERDQRLL-------ELMNQLKKLEDRCAQAESQAALASRYSDEIER-------------------
----------------LNNSMREIAQAVVQDAEN---ADREADAEVTGGVMQHMHLTRDAASVVGGAGGAGSTAG-----
-----GGGKSPRRNS-TRASQAFAEGTISAVQAALHKYQLALHDMQVKFQNTSETLRTTKAQLETSEGTKQLLTTKMQQL
TE----KLDSSNSKLSELLQERESLQRGLDDIRV----------------------------QKQQSEMGRADINSAFEN
LSSDY----------EKMQLNCGKLQKRIDSMEEDKKAVELEIQRILK--DKNITELNLRS-------EEDRSSRLREET
ISLREELNRVSLNRDLLEQQRIESDNLINLLE-KQKSDLEYDLDKLLLEKCDLQEKHEKLSNNSCSTSDELKSVQNCLQE
-------------------------AQEERKKLRIQSVDQCNEIGELKKELAILDKARLELETDNLSAGEKLKCLQLEKE
KILQDLACVTRDRGDIH---------------------NQLTAMCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMV
KDVEEKQVVIDLHEKDTHRLNELLAA-----LRSEK--ESLESVLFDTNTSLEATEERRSQLERDLQEALVREESLKN--
--HVARLQKELEQCQRKAQETKTQLLNAARAAESDFN------QKIANLQACAEEAAKR--HGEEILQLRNALEKRMQQA
LQALQTAKDDEIEKL-------------QERLATLQAHLESLVQQHEEALIRAES-------------------------
--------------------------------------------EKQQALLIAHRDKQAVAERLEAVSRDLKTEQESLDR
SRREANARDEKQRA-------AIAQLKDEMVQMRTKEEEHKIKLEECIRKQELQLSSLREERESLCR-------------
----------------VSEEL-------------KMEIRLKEDRMES-TNNELQDALRKSKEGEGFIDSLRKELTDCRRQ
LADSNIERDKYSGSNKELRDHVKRVESAKREQARAIEEALQKISNLEDTKNSLENERTRLSTILKETENHFTKTTQDLNA
TKAQLQ--------------------------------------------------------------------------
------------------------------------------------------------------------KAQVEFAQ
KDEGGKELQCKLVAEVELKERAQQELCQIKKQLSDLEANLCA---TRQELGRARCQNNQEEHRFHARE----------QE
LAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGAEGRIRALDEQLSCVELHKR-DTEQKLSSVVHTLRRIA
GIQVDGSVNLS------------------------------HRLLSPSRRFSPSRS-------CGDYDNRS---------
----TSQCPD--------------------------------------------------------------GP---IDV
DPDLVRKGVRNLMHQVAQLERE----KDDYKSQLGAAK-KQLQDAADQQLRCDAKLGKLQAMLRNLQEEKSN----LETD
RKMKISAIQALEEKLKHRNDECQMLRERLAQTEMQLAATSEENGQNEERLEKSRQQCSK---------------------
------------LDNEKRQLQEELAKVEGRASKLELQRVAMEGDLTRLQMALQEKDCSIRQMA--ERLENQNRALTQLED
RCTALKSTVDQLKERLQKSAVSETQLRGEIKTLQKELSEQGHCSQANE----DKLKLVQKSLQTAENEKRILTERLDSAQ
TNLNELRRSQQAQLDGNQRLQEQVTDLEVQRSALESQLRIAKWNQESGGDKDLTNGNGGG--------------------
--------------------------------------------------------------------------------
-----------NGEEELSRQLKSSQREKSELRSKLQTLQDKVKQLECDRKSKFSGGNAYDRAEKSNSFYGGAAESGEFDS
NRYDVGGGNAGGGSFNCGLDHSVIEQETRDLRLKVRRLET----------------------------------------
--------------------------------------------------------------------------------
--LLAEKESELARCKARMNDSAKCHDGLDG-------DRYRSAQMHAEKLLDAREQSHRQQVLRLENQ-ISMLREQLAQE
AKRRQQYILRSSKANREMQHLRSTLGDSLRNVS-------------------------------QHP-VDPHLLESESRR
LDSAVS--MSLPPSSCR------DYDRD----------------------------------------------------
--------------------------------------------------------------------------------
-------------------
>Apis_mellifera_CEP250
--------------------------------------------------------------------------------
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------------------------------------------------------------------------MSRPLPKN
ISQLSARG----------------QMERRRPPFLR-----------GPSRMREKIERGIGS-------------------
-----------------------------------------------KMDSTG---STLSGTGDCLSEEDLSPDALVRQN
YELRHRLEEEAAN----YKRRLDTYRQAQQHQAALVSRLQAKVLQYKQKCSELENQMAESIVYDSN-KVVSSAPPTTSVL
DAAHQTLREIREEQIYDLDT--------------------------------------------------------ALKK
LSEERKRCEKLLQLNTTLKDQLEESHQTNEALTNDLQKLSNDWDILREELAIKEEEWREEEQAFN---DYYTSEHNRLLI
LWRDVVSVKRLFADIKSSTERDLLKMKNNIISTFNDVSSACNNTGFAMRMQAAMHPMISQQVQQ---AQEQVTTDLKTEL
ITLKQQYDVAQNEIRIKEEKIN-------QLIRDVHSLEERCGEAETEIHRNTRLQDDIEI-------------------
----------------LQSALRDIAHAVIQDAES-----REIESTQAP---PHLHLSPTGPIPQ----------------
--------KSPKRGTRSNTIPAFAESTISAVQAALHKYQLTIHELQVKLQTNKEQLQNTRKQCENAEENVKTLEKKAEEL
II----ELDAVRLHCSQLNQEKDMLQKGLDTIRI----------------------------EKNTLEKTRIELNNMMEN
LNNDC----------EKLQKANNKLQKICDNLEDEKLYLQSELNRLSK--DVELRELNLRS-------EEDRCSKMREEL
LTLREELNKTYLSKDMLEQQKLETDGLISQIE-KSKGDLELELERVLLEKSDVQEVLMKLETVCSNHEQEKQRLQEELKK
-------------------------VTEEKNKLANQCTDQQGDLGSLRKELLQAEQTRLDLESEKVTLNEKVKFLEIEKE
KIEIELAQVTRERGDFN---------------------NQLSVLARKKETLNEELMRLKQRLEQANEMNGRINRNLEDLV
KDNEEKQVLLETNEKEVQRLQEQLAS-----MRSEK--ETLEGVLFDTQTSLENMHVKKTQLEKEQKELLIKQESLKG--
--QVERLMKDLENSEKRIHEVKQTLTQQSGDQEAEFQ------QIISNVKKHSEENIKK--LNEEKEQIKINLEKRLQQS
LLQVTGEKDNEINQL-------------QQRIDEMQQHIENLCQQHEEVLLRAEN-------------------------
--------------------------------------------DKQQALLIAHHDQQALMEKLETVLHEMEEEKNNVER
VKREAAVKTEQERN-------NINQLRDELNRLKTKLDETRLKTDEEKIKLDLKIEELWKERELAQR-------------
----------------ESEEL-------------QVQLHMTEDKVDS-LQNQLHETIRKLKDAENLNETLRKELVDIRRQ
LGDSTYEKEKYNSSNKELREHVKRIESEKREQNRILEESYQKISALEDMKVNVDAERSRLQAQIRDMEKEMLQLQKQLHF
TQDELQ--------------------------------------------------------------------------
------------------------------------------------------------------------KSHQSNAQ
AQNDEKELQARLTNETEERERLQLQLHQVKKQLMDVDNSLKV---TRQELGRLRSRADEENERWRVRE----------QE
LVVRLEDSRCRERKLEDQKHNLEVCLADASQQIQELKARLGGSEGRVRALDAQLSQLEITKK-EVEQKLSSVGSTLRRIA
GIQMDGSVNIP------------------------------FKLLSPSRRWSPARA--------QDHIDSS---------
-------------------------------------------------------------------------RDVILDV
DPEIIRKGVRSLMQQVAQIERE----RDDYKTELCNLK-KQLDENQEIQNRSDIQINTLLTNIRMLQDEKNS----LEVK
LSQKQSGYEMQ-------SEECEQLREKIINLELMISNNSEEKIQFEEKLDKLKQVLNK---------------------
------------VENEKRNLQEELSKSESRATKLELQRMSLEGDLQRLQMMFQEKDANIHKLQ--ERNDTQNRTMTTLEE
RCTSLKSMVEQLNLALEKASTTENELKNEINSMQHNIMELTTTLQTSN----EKNKQLQKQISNAENERRILSERIESMQ
QSLNDLKHTNQTLTDQITRLQNELANNEVQRCALESQLRIVAYPTQEEN-------------------------------
--------------------------------------------------------------------------------
----------INKDEELLRQLQIAQRERSEMRGKMEALNDKMKLLEADKRNLERQLSLFKSTNRSKS-------YERYEK
AHTELLG---------TSFDIDHYEQENRELRLKVRRLET----------------------------------------
--------------------------------------------------------------------------------
--QLAEKEAELIRLKSSYTHTHSVFDFNRDRTG--EIERLRAAQLQAEKLLEAREQSHRQQVLRLENQ-IQLLREQLNQE
IKRRQLYVLRSSRAGREMQQLRQALGDSLRTVA-------------------------------QDPSLDAVLLEHEARK
LDSTLTSTTSLPPSLALPPPP--SYDRSSTPAQLK---------------------------------------------
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>Amphimedon_queenslandica_CEP250
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-MEEQETKAPPEEATKDTDSASGDGESKDVRVESTFEELEKEFEEVLQEMVGDGSLGKFKTEYEK---------------
-----------LHKALIKSHESEKRLMLQCQELNAELISNASKVTSALKITQDDKATISSQKQE----------------
------------------------------IEKLWRAVDDAQDKETKTHETIHQLKLENIS-------------------
--------------------------------------------------------------------------------
----------------LNKLIENGAGFGPAMQESMKALEKEKEELTVERDEQMEEISALRTELSELMEKRKEAENERESV
EL-----------KVLQLQEEITAKNQEIDRDSR----------------------------RKAKLEKDLRGVQAEVDN
KVEEI-------------KAKQAQLNKAHEDYAKAEQVLKDTQKKYEN--------------------SVKQNEALEVML
DKKKKEYDQEVNRNEELARQNSEQIMELKMKE-ESINEFKQEIMKINKIREGLQKKLREIEERKANVEANRDSLMQQIAS
-------------------------IEKELEQERRQAESERRSFDELLRERDIISKSLRKSEGSAERLEHLMKMKEQTIK
TLQHEITNFKEEAKKQR------------------------SLLLQLEKERDKYGKESTDATQKCLQQMEEVKRKELEML
QQKKLIAEAQNKLQQQKTLYEAASSD-----------RSLYSKQLIEARDEITDMKRRIKILSHQIDQLKEEIAAKDG--
------AMVKVNADLMHLEREKDNLSAEISGRKQELE------AARQLLENQKNEEKKLRKVLTEASTESARQKKELEQV
INERDILGTQVIRRN--------------DELSLLYEKIKIQQSTLDKGEIQYKS-------------------------
------------------------------------------------------------------RVEDIRILKLEIKK
LRREKGLLTKSVAN--------IEDLKRELCQCQRELLRERTRCKAIEEELENPINIHRWRKLEASD-------------
--------------------------------------------------------------------------------
LGTYEMIQKIHTLQKKLIQKTEEVVEKELLIQEKEKLYMDLKQILQRQPGPEVAEQLQIYQQTLKEKTKQMKSMASELNM
YETQVA--------------------------------------------------------------------------
------------------------------------------------------------------------EHKMDIDR
LERELQEVKKKYYLQKKKEHIQKERERMLTKGLAPPVIPKAT-----TNMPRFTGGGFNLKPNVLA--------------
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