>Homo_sapiens_CHRNB2
--------------------------------------------------------------------------------
-----------------------------MARRCGPVAL----------------LLGFGLLRLCSGVWGTDTEERLVEH
LLDPSR-YNKL-------------------------------------IRPATNGSEL----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWEDYR-LTWKPEE-------------------
--FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSEV----------------------------ASLDDFT-
-PSGEWDIVALPGRRNENPD------------------------DSTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MAPWVKVVFLE-------------KLPALLFMQQ-----------------------------------------
-------------PRHHCARQRLRLRRRQREREG----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------AGA---LFFREAPGADSCTCFVNRASVQG---
----LAGAFGAEPAPVA--------------------------------------GPGRSGEPCGCGLREAVDGVRFIAD
HMRSE-DDDQSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-IGMFLQP--LFQNYTTTTFLHSDHSAPSSK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Pan_troglodytes_CHRNB2
--------------------------------------------------------------------------------
-----------------------------MARRCGPVAL----------------LLGFGLLRLCSGVWGTDTEERLVEH
LLDPSR-YNKL-------------------------------------IRPATNGSEL----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWEDYR-LTWKPEE-------------------
--FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSEV----------------------------ASLDDFT-
-PSGEWDIVALPGRRNENPD------------------------DSTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MAPWVKVVFLE-------------KLPALLFMQQ-----------------------------------------
-------------PRHHCARQRLRLRRRQREREG----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------AGA---LFFREAPGADSCTCFVNRASVQG---
----LAGAFGAEPAPVA--------------------------------------GPGRSGEPCGCGLREAVDGVRFIAD
HMRSE-DDDQSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-IGMFLQP--LFQNYTTTTFLHSDHSAPSSK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRNB2
--------------------------------------------------------------------------------
-----------------------------MARCSNSMAL----------------LFSFGLLWLCSGVLGTDTEERLVEH
LLDPSR-YNKL-------------------------------------IRPATNGSEL----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWEDYR-LTWKPED-------------------
--FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSDV----------------------------ASLDDFT-
-PSGEWDIIALPGRRNENPD------------------------DSTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MAPWVKVVFLE-------------KLPTLLFLQQ-----------------------------------------
-------------PRHRCARQRLRLRRRQREREG----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------AGT---LFFREGPAADPCTCFVNPASMQG---
----LAGAFQAEPA-AA--------------------------------------GLGRSMGPCSCGLREAVDGVRFIAD
HMRSE-DDDQSVR-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-IGMFLQP--LFQNYTATTFLHSDHSAPSSK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Canis_familiaris_CHRNB2
--------------------------------------------------------------------------------
-----------------------------MATRSGPAAL----------------LLGFGLLGLHAGVWGTDTEERLVEH
LLDPSR-YNKL-------------------------------------IRPATNGSEL----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWEDYR-LTWKPEE-------------------
--FDN---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTMKFRSWTYDRTE----IDLVLKSDV----------------------------ASLDDFT-
-PSGEWDIVALPGRRNENPD------------------------DSTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MAPWVKVVFLE-------------KLPTLLFMQQ-----------------------------------------
-------------PRHRCARQRLRLRRRQRERE-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------AGA---LLFREAPGES------YSGSARG---
----GVGTDG-------------------------------------------------------CGLRSAVDGVRFIAD
HVRNE-DDDQSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-IGMFLQP--LFQNYSAATFLHTDHSAPSAK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Xenopus_tropicalis_CHRNB2
--------------------------------------------------------------------------------
-------------------------------------YI----------------SCRDFAFAFGTGCLGTDTEERLVEH
LLDPSR-YNKL-------------------------------------IRPATNGSEQ----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWEDYR-LTWDPAE-------------------
--FDD---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSHDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTMKFRSWTYDRTE----LDLVLRSDV----------------------------ASLDDFT-
-PSGEWDIIALPGRRNENPN------------------------DSTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MPPWVKVVFLD-------------KLPTLLFMKQ-----------------------------------------
-------------PRQNCARQRLRQQRQSQER------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------AAGSFFLRD--GARSCTCYVNQASVKKYGA
QLSELPEGVNGFRDRQG--------------------------------------KVR----QCLCGLQEAVDGVRFIAD
HMKSE-DDDQSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-IGMFLQP--LFQNYTTNALVHMNHAAKKMK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNB2_a
--------------------------------------------------------------------------------
-----------------------------------MMAL----------------WTLFCILAIVKSGYGADTEERLVEH
LLNPAH-YNKL-------------------------------------IRPATNGSEV----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWQDYR-LTWSPEE-------------------
--FDG---MKKVRLPSKHIWLPDVVLYNN------ADGMYEVS-----FYSNAVVSYDGSVFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTLSFRSWTYDRTE----VDLVLRADV----------------------------ASMDDFT-
-PSGEWDIIALPGRRNENPS------------------------DPTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MPPWVKLVFLN-------------KLPALLFMRQ-----------------------------------------
-------------PRNSSERQRLRQRRRANEQQEGGRGGLAAGLMAGLG-------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------LSGSSSG---------SKENNEACTCYVNRASVKQFG-
------AELGGGGGGGGSTDGLNGIREGGRETREGGANPLQGSALPRGKQQPPTVLTQALLAQACPGFEEAVDGVRFIAN
HMKSE-DDDRSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-IGMFLQP--LFQNYTAKTITHTPG----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNB2_a
--------------------------------------------------------------------------------
-------------------------TAVLPSSLHPSIQA----------------LLFQYAWMVGS-----DTEERLVEH
LLNPAH-YNKL-------------------------------------IRPATNGSEL----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQVMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWQDYR-LTWIPEE-------------------
--FDG---MLKVRLPSKHIWLPDVVLYNN------ADGVYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTLRFRSWTYDRTE----IDLVLRADV----------------------------ASMDDFT-
-PSGEWDIIALPGRRNENPG------------------------DPTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MPPWVKMVFLQ-------------KLPALLFMRQ-----------------------------------------
-------------PRNSCERQRLRQRRRAQEHKEGG--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------IFGKEDSDPCTCYVNRASVKQFG-
------GDLGGAGG----------------------------------SMDGLNRARDGREAQACPGFEEAVEGVRFIAN
HMKSE-DDDQSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-MGMFMQP--LFQNYTAKTINSSPG----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNB2_a
--------------------------------------------------------------------------------
-------------------------------------------------------------------GLCADTEERLVEH
LLNPAH-YNKL-------------------------------------IRPATNGSEL----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQVMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWQDYR-LTWIPEE-------------------
--FDG---MLKVRLPSKHIWLPDVVLYNN------ADGVYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTLRFRSWTYDRTE----IDLVLRADV----------------------------ASMDDFT-
-PSGEWDIIALPGRRNENPG------------------------DPTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MPPWVKMVFLQ-------------KLPALLFMRQ-----------------------------------------
-------------PRNSCERQRLRQRRRAQEQKGGGRCGEPGGLMVGNG-------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------LGNAGGSGGGTTTGLFGKEDSDPCTCYVNRASVKQFG-
------GDLGSAGGGSMDGL---------NRAREAREGG-SGNQSRGKPGTGAPALSHALLAQACPGFEEAVEGVRFIAN
HMKSE-DDDQSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-MGMFLQP--LFQNYTAKTINSSPG----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNB2_a
--------------------------------------------------------------------------------
-------------------------------------------------------------------GLGADTEERLVEH
LLNPAH-YNKL-------------------------------------IRPATNGSEL----------------------
--VTVQLMVSLAQLISV-H-------------------------------------------------------------
-----ER-EQVMTTNVWLT-------------------------------------------------------------
----------------------------------------------QEWQDYR-LTWVPEE-------------------
--FDG---MLKVRLPSKHIWLPDVVLYNN------ADGVYEVS-----FYSNAVVSYDGSIFWLPPAIYKSACK----IE
VK-------HFPFDQQNCTLRFRSWTYDRTE----IDLVLRADV----------------------------ASMDDFT-
-PSGEWDIIALPGRRNENPA------------------------DPTYVDITYDFIIRR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPT
-THT-MPPWVKLVFLN-------------KLPALLFMRQ-----------------------------------------
-------------PRNSCERQRLRQRRRAQEQKEGGRSGEAGALMVGLG-------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------LGNASGNRGGTSTGVFSKEDSDPCTCYVNRASVKQFG-
------GDLA-------------------------------------------------LLAQACPGFEEAVEGVRFIAN
HMKSE-DDDQSVS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRLFLWIFVFVCV
FGT-LGMFMQP--LYQNYT-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Ciona_intestinalis_CHRNB2
--------------------------------------------------------------------------------
---------------------------------MGSRCW----------------LIAVCLCYVIRECLSAHAEEKLLRH
LLDPVR-YNKL-------------------------------------IRPSESITSK----------------------
--VDVHFDLIISQLIGI-N-------------------------------------------------------------
-----ER-EQYMITKVWLP-------------------------------------------------------------
----------------------------------------------QVWVDKR-LSWQPMR-------------------
--YEN---ITKVQLPSNMIWLPDVVLYNN------ADGMYEVS-----LQSNAIILNNGTVTWMPPAIYKSACK----IK
VR-------HFPFDEQNCTMMFRSWTYNRLD----IELKLKNPN----------------------------ATLDDFT-
-PSGEWDILQTPGSVNVNPN------------------------DETYQDLLYSLIIRR---------------------
--------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMMLVTLSIVASVCVLNIHHRSPS
-THT-MPPWIRTIFLN-------------HLPPLLGMER-----------------------------------------
-------------PGTDDRCRCKVNDATYGVDVT----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------ELSGSDVIRNRKRG-----
----------------------------------------------------------KSEVKLPRDVSSALEGVKFIAD
HLRAE-DENKNV--------------------------------------------------------------------
--------------------------------------------------------HEDWKYVAMVIDRMFLFVFVGVCA
IGT-IGIFIQP--FV-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Ciona_savignyi_CHRNB2
--------------------------------------------------------------------------------
------------------------------------------------------------------ECTSAHAEEELLRH
LLDSGR-YNKL-------------------------------------IRPSQS--------------------------
-----NFDLIISQLIGI-N-------------------------------------------------------------
-----ER-EQFMITKVWLP-------------------------------------------------------------
----------------------------------------------QVWVDER-LSWQPTE-------------------
--YEN---ITKVQLPSDMIWLPDIVLYNN------ADGTYEVS-----LQSNAIILNNGTVTWMPPAIYKSACK----IK
VR-------HFPFDEQNCTMMFRSWTYDRDD----IELKLMNPN----------------------------ATLDDFT-
-PSGEWDILATPGMMNLNAD------------------------DPSYQDLLYSLVIRR---------------------
--------------------KPLFYTVNLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMMLVTFSIIASVCVLNIHHRSPS
-THE-MSPWIRRTFLQ-------------VIPPLIGMQR-----------------------------------------
-------------PGTDQ---CSYN--KYKVDVS----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------DLSGSDVIRKRK-------
----------------------------------------------------------QPEVQLSRDISSALEGVKLISD
HLKAE-DRNKNVSFIGYLYILEYLIFRLTRMLIRGYISFIVLLDSPTPAVHVQFRSQGWIRQHLFNLSS-----------
---------------------------------------------------CELVIHEDWKYVAMVIDRMFLFVFVVVCA
VGT-VSIFLQP--FV-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Branchiostoma_floridae_CHRNB2
--------------------------------------------------------------------------------
-----------------------------------MLVT----------------KVNVSFCRSHTETLAAEAEERLVQR
LFNESR-YNPL-------------------------------------IRPARYNGEK----------------------
--VLVHFRLSISQLINV-D-------------------------------------------------------------
-----EK-NQKMKTNVWLH-------------------------------------------------------------
----------------------------------------------QEWFDYR-LSWDPRE-------------------
--YDN---IKVIRVPSEIVWRPEIVLFNN------ANGQYDVQ-----LMPKCLIYSGGNITWIPPAIYESACQ----ID
VR-------FFPFDQQNCSMKFASWTYDGTE----LDLELKDTN----------------------------AVMDDFK-
-KNGEWDILRLPGRKSSHAG------------------------DP-LPYVYFDFILMR---------------------
--------------------RPLFYTINLIIPCILITSLSVLVFYLPSDCG-------------------EKITLS----
ISVLLALTVFLLLI----------------------ADIIPPTSLDVPLIGKYIMFTMIFVTFTIVTTVYILNVHHRHPS
-THT-MPPWVRTVFLD-------------KLPRLLLMKR-----------------------------------------
--------------PNQCR------KYALRVSESSARN------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------PHEDFPEDHTDSPYYSPRTRPAH---
------THYKQID------------------------------------------LPPEVPSDLPPELKKAVKNVRYIAD
YFRSH-DQDLSIS-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVIDRIFLWTFVSVCF
IGT-LGLFLQP--LL-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNG
-------------------------------------------------------------------------------M
HGGQGPLLLLLLLAVCLGAQGRNQ-------------------------------------------------EERLLAD
LMQ---NYDPN-------------------------------------LRPAERDSDV----------------------
--VNVSLKLTLTNLISLNE-------------------------------------------------------------
-----R--EEALTTNVWIE-------------------------------------------------------------
----------------------------------------------MQWCDYR-LRWDPRD-------------------
--YEG--LWV-LRVPSTMVWRPDIVLENN------VDGVFEVA-----LYCNVLVSPDGCIYWLPPAIFRSACS----IS
VT-------YFPFDWQNCSLIFQSQTYSTNE----IDLQLSQEDGQT--------------------IEWIFIDPEAFT-
-ENGEWAIQHRPAKMLLDPAA--------------------PAQEAGHQKVVFYLLIQR---------------------
--------------------KPLFYVINIIAPCVLISSVAILIHFLPAK-AGG-----------------QKCTVA----
INVLLAQTVFLFLV----------------------AKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLR-SP
HTHS-MARGVR----KVF---------LRLLPQLLRMHVRPLAPAAVQDTQ-----------------------------
----------------SRLQNGSS-GWSITTGEEVAL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------CLPRSELLFQQWQ-RQGLVAAALEK-
--------------------------------------------LEKGPELGLSQ-FCGSLKQAAPAIQACVEACNLIAC
ARHQQSHFDNGNE-------------------------------------------------------------------
----------------------------------------------------------EWFLVGRVLDRVCFLAMLSLFI
CGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gorilla_gorilla_CHRNG
-------------------------------------------------------------------------------M
HGGQGPLLLLLLLAVCLGAQGRNQ-------------------------------------------------EERLLAD
LMQ---NYDPN-------------------------------------LRPAERDSDV----------------------
--VNVSLKLTLTNLISLNE-------------------------------------------------------------
-----R--EEALTTNVWIE-------------------------------------------------------------
----------------------------------------------MQWCDYR-LRWDPRD-------------------
--YEG--LWV-LRVPSTMVWRPDIVLENN------VDGVFEVA-----LYCNVLVSPDGCIYWLPPAIFRSACS----IS
VT-------YFPFDWQNCSLIFQSQTYSTNE----IDLQLSQEDGQT--------------------IEWIFIDPEAFT-
-ENGEWAIQHRPAKMLLDPAA--------------------PAQEAGHQKVVFYLLIQR---------------------
--------------------KPLFYVINIIAPCVLISSVAILIYFLPAK-AGG-----------------QKCTVA----
INVLLAQTVFLFLV----------------------AKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLR-SP
HTHS-MARGVR----KVF---------LRLLPQLLRMHVRPLAPAAVQDTQ-----------------------------
----------------SRLQNGSS-GRSITTGEEVAL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------CLPRSELLFQQWQ-RQGLVAAALEK-
--------------------------------------------LEKGPELGPSQ-FCGSLKQAAPAIQACVEACNLIAC
ARHQQSHFDNGNE-------------------------------------------------------------------
----------------------------------------------------------EWFLVGRVLDRVCFLAMLSLFV
CGTAGIFLMAHYNRVPALPFPGDPHPYLPSPD------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRNG
-------------------------------------------------------------------------------M
QGGQRPQLLLLLLAVCLGAQSRNQ-------------------------------------------------EERLLAD
LMR---NYDPH-------------------------------------LRPAERDSDV----------------------
--VNVSLKLTLTNLISLNE-------------------------------------------------------------
-----R--EEALTTNVWIE-------------------------------------------------------------
----------------------------------------------MQWCDYR-LRWDPKD-------------------
--YEG--LWI-LRVPSTMVWRPDIVLENN------VDGVFEVA-----LYCNVLVSPDGCIYWLPPAIFRSSCS----IS
VT-------YFPFDWQNCSLVFQSQTYSTSE----INLQLSQEDGQA--------------------IEWIFIDPEAFT-
-ENGEWAIRHRPAKMLLDSVA--------------------PAEEAGHQKVVFYLLIQR---------------------
--------------------KPLFYVINIIAPCVLISSVAILIYFLPAK-AGG-----------------QKCTVA----
TNVLLAQTVFLFLV----------------------AKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLR-SP
HTHS-MARGVR----KVF---------LRLLPQLLRMHVRPLAPAAVQDAR-----------------------------
----------------FRLQNGSSSGWPIMAREEGDL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------CLPRSELLFRQRQ-RNGLVQAVLEK-
--------------------------------------------LENGPEVRQSQEFCGSLKQASPAIQACVDACNLMAR
ARRQQSHFDSGNE-------------------------------------------------------------------
----------------------------------------------------------EWLLVGRVLDRVCFLAMLSLFI
CGTAGIFLMAHYNQVPDLPFPGDPRPYLPLPD------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Xenopus_tropicalis_CHRNG
--------------------------------------------------------------------------------
-RGGMDTVLLLVLICISAALCHNE-------------------------------------------------EEGLLND
LMK---NYNKN-------------------------------------LRPAEKDGDI----------------------
--VSVSIKLTLTNLISLNE-------------------------------------------------------------
-----R--EEALTTNVWVE-------------------------------------------------------------
----------------------------------------------VQWRDYR-LSWDPNE-------------------
--YYG--ISM-MRIPSTSVWLPDVGLENN------VDGTFDIA-----LYANTLVSSDGSMYWLPPAIYRSSCP----VV
VT-------YFPFDWQNCSMVFQSQTYSANE----IELLLTVDE-QT--------------------IEWIEIDPEAFT-
-ENGEWAIKHMPAKKIIN-HRL-------------------TPDDLNYQQIVFYLIIQR---------------------
--------------------KPLFYIINIIVPCVLISFVSILVYFLPAK-AGG-----------------QKCTVS----
INILLAQTVFLFLI----------------------AQKIPETSTAVPLIVKYLTFLMVVTITIVANAVIVLNISLR-TP
NTHS-MSSTVR----ELC---------LRTVPRLLRMHLR--PSDAAPP-------------------------------
---------------LAPLMRRSSSVGLMIKADEYML-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RKPRSQLMFEKQKERDGLMKVVLDK-
--------------------------------------------IGRGMENNTSDDLVHSLKHAAPEIRACVEACCHIAS
ATREKNEFKSTGDN------------------------------------------------------------------
----------------------------------------------------------DWKCQSKVL-------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNG_a
------------------------------------------------------------------------------MD
QNLSSKIIWLWILLFRFSGALCNL-------------------------------------------------EGSLHRD
LMV---GYNKN-------------------------------------IRPVESHEDI----------------------
--IDVKIKMTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTCVWIE-------------------------------------------------------------
----------------------------------------------MQWRDYR-LRWANRTGFE----------------
-VYEN--ITR-MRLPSKTIWLPDIGLENN------VDGRFEVA-----LYANTLIDPDGSVYWLPPAIYRSSCA----IK
VN-------YFPFDWQNCSMVFRSQTYNSNE----ITLMLSDEDNVT--------------------MEWIEIDPEAFT-
-ENGEWMIKHRPAKKVIN-KRY-------------------RPDELEHQEIIFFLIIQR---------------------
--------------------KPLFYVINIIVPCVLFSSLGLLVYFLPAK-AGG-----------------QKCTMT----
ICILLGQTVFLFLI----------------------AKKVPETSQAVPLIGKYLMFVMSVTTITVMNCVVVLNVSLR-TP
NTHP-MSNTIR----KVL---------LNILPRVLRMTMQRWTPEQEEGDFKMFAL------------------------
------------GNGTPLRRRRRSSLGLIAKADEYMF-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------RTARSELMFSRLKERKGLLKNTLEK-
--------------------------------------------IQNGLGGNTAQDLECSLAAASPEVQQCVSSCKHIAE
STKHQNDFQSKNE-------------------------------------------------------------------
----------------------------------------------------------EWFLVARVIDRMCFFVMALLFI
LGTIGIFLTGHFNQAPSQPFPGDPKKYLPEISAGDIPG------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNG_a
-----------------------------------------------------------------------------MDS
GCPLSLSLFIRVFMISAAASAVNL-------------------------------------------------EGELFKD
LMK---GYNKN-------------------------------------VRPTEKSGDI----------------------
--TQVDIKLTLTNLISLNE-------------------------------------------------------------
-----K--EEALTTSVWIE-------------------------------------------------------------
----------------------------------------------LQWCDYR-LRWDQPPRST----------------
-LYGN--ITKPLRIPSKILWLPDIILENN------VDGQFEVA-----LYCNALVSPDGCVYWLPPAIYRSACP----IT
VN-------YFPFDWQNCTMVFRSQTYSANE----IDMVLKVEDNHT--------------------LEWVDIDPEAFT-
-ENGEWAIKHRPAKKVIN-SQY-------------------TKDDREYQEVIFFLIIQR---------------------
--------------------KPLFYIINIIAPCVLFSSLCLLVYYLPAK-AGG-----------------QKCTMS----
VATLLGQTVFLFLI----------------------AKKVPETSKAVPLIAKYLMFVMSVTTMVVMNCVIVLNVSLR-TP
STHI-MTDAVR----KVL---------LNILPRLLKMQMRPWTPNNDST-------------------------------
---------------PEIRNRRRSSMTLITKAEEYAM-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KTARSELMFSRLKERNGLMKSVLEK-
--------------------------------------------LHDGLDGGTPEQLGISLAKASPEVKKCVASCKHIAE
TARQQSNFQNENE-------------------------------------------------------------------
----------------------------------------------------------EWFLVARVIDRACFIVMASVFF
IGTIGVFLMGHFNQPPSAPFPRDAKTYLPPIN------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNG_a
-------------------------------------------------------------------------------S
GCRLSLSFFVTVFTISAAASAVNL-------------------------------------------------ERELFKD
LMK---GYNKH-------------------------------------VRPTEKSGDI----------------------
--TQVDIKMTLTNLISLNE-------------------------------------------------------------
-----K--EEALTTSVWIE-------------------------------------------------------------
----------------------------------------------LQWCDYR-LRWDQPPRAA----------------
-LYGN--ITKPLRIPSRIIWLPDIILENN------VDGQFEVA-----LYCNALVSPDGCVYWLPPAIYRSACP----IT
VN-------YFPFDWQNCTMVFRSQTYSANE----INMVLKVEDNHT--------------------LEWVDIDPEAFT-
-ENGEWAIKHRPAKKVIN-RQY-------------------TKDDQEYQEVIFFLIIQR---------------------
--------------------KPLFYIINIIVPCVLFSSLCLLVYYLPAK-AGG-----------------QKCTMS----
IATLLGQTVFLFLI----------------------AKKVPETSKAMPLIAKYLMFVMSVTTMVVMNCVIVLNVSLR-TP
STHI-MTDTVR----KIL---------LNILPRLLKMRMRPWTPNKDS--------------------------------
----------------AFPCRRRSSMTLITKAEEYVM-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KTARSELMFSRLKERNGLMKSVLEK-
--------------------------------------------LHEGLDGGTPEQLSISLAKASPEVKKCVASCKHIAE
TARQHNNFQNENE-------------------------------------------------------------------
----------------------------------------------------------EWFLVARVIDRVCFIVMASVFF
IGTMGVFLMGHFNQPPSTPFPGDVKMYLPP--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNG_a
--------------------------------------------------------------------------------
-----VIHILTIFICIEKTSAINL-------------------------------------------------EGELFKD
LMK---GYNKN-------------------------------------VRPMENGSDV----------------------
--TQVAIKMTLTNLISLNE-------------------------------------------------------------
-----K--EEALTTGVWIG-------------------------------------------------------------
----------------------------------------------MQWCDYR-LRWDRPPRSA----------------
-LYGS--ITSQLRLPSKSIWLPDIILENN------VDGNFEVA-----LYCNALVSPNGCVNWLPPAIYRSACA----IT
VN-------YFPFDWQNCTMVFHSQTYSANE----IKLVLTEEDDLT--------------------LEWVDIDPEAFT-
-ENGEWAIKHRPAKKLIN-TDY-------------------NKDELEYQEVVFFLIIQR---------------------
--------------------KPLFYVINIIAPCVLFSSLGLLVYFLPAK-AGG-----------------QKCTMS----
IATLLGQTVFLFLI----------------------AKKVPETSRAVPLIGKYLMFVMSVTTMVVMNCVIVLNVSLR-TP
NTHK-MTDKVR----KIL---------LNILPRLLNMQMRPWTPDGDN--------------------------------
-----------------ADTRRRSSMTLITKAEEYAM-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KTARSELMFAALKERNGLMRSVLEK-
--------------------------------------------LKDELEGGTAEQLSASLGKASSQLQQCVSSCKHIAK
TARQQNNFKKENE-------------------------------------------------------------------
----------------------------------------------------------EWFLVAKVIDRVCFIVMVSVFF
IGTIGIFLTGHFNQPPSSPFLGDPKTYLPPTNNLTDRVENGR--------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRND
-----------------------------------------------------------------------------MEG
PVLTLGLLAALAVC---GSWGLNE-------------------------------------------------EERLIRH
LFQE-KGYNKE-------------------------------------LRPVAHKEES----------------------
--VDVALALTLSNLISLKE-------------------------------------------------------------
-----V--EETLTTNVWIE-------------------------------------------------------------
----------------------------------------------HGWTDNR-LKWNAEE-------------------
--FGN---ISVLRLPPDMVWLPEIVLENN------NDGSFQIS-----YSCNVLVYHYGFVYWLPPAIFRSSCP----IS
VT-------YFPFDWQNCSLKFSSLKYTAKE----ITLSLKQDA----------------KENRTYPVEWIIIDPEGFT-
-ENGEWEIVHRPARVNVDP-RA-------------------PLDSPSRQDITFYLIIRR---------------------
--------------------KPLFYIINILVPCVLISFMVNLVFYLPAD---S----------------GEKTSVA----
ISVLLAQSVFLLLI----------------------SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFR-TP
STHV-LSEGVKKLF-------------LETLPELLHMSRPAEDGPSPG--A-----------------------------
------------------LVRRSSSLGYISKAEEYFL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------LKSRSDLMFEKQSERHGLARRLT---
------------------------------------------------TARRPPASSEQAQQELFNELKPAVDGANFIVN
HMRDQNNYNEEKD-------------------------------------------------------------------
----------------------------------------------------------SWNRVARTVDRLCLFVVTPVMV
VGTAWIFLQGVYNQPPPQPFPGDPYSYNVQDKRFI---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRND
-----------------------------------------------------------------------------MAG
PVLTLGLLAALVVCALPGSWGLNE-------------------------------------------------EQRLIQH
LFNE-KGYDKD-------------------------------------LRPVARKEDK----------------------
--VDVALSLTLSNLISLKE-------------------------------------------------------------
-----V--EETLTTNVWID-------------------------------------------------------------
----------------------------------------------HAWVDSR-LQWDAND-------------------
--FGN---ITVLRLPPDMVWLPEIVLENN------NDGSFQIS-----YACNVLVYDSGYVTWLPPAIFRSSCP----IS
VT-------YFPFDWQNCSLKFSSLKYTAKE----ITLSLKQEE----------------ENNRSYPIEWIIIDPEGFT-
-ENGEWEIVHRAAKLNVDP-SV-------------------PMDSTNHQDVTFYLIIRR---------------------
--------------------KPLFYIINILVPCVLISFMINLVFYLPGD---C----------------GEKTSVA----
ISVLLAQSVFLLLI----------------------SKRLPATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFR-TP
STHV-LSEGVKKFF-------------LETLPKLLHMSRPAEEDPGPR--A-----------------------------
------------------LIRRSSSLGYICKAEEYFS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------LKSRSDLMFEKQSERHGLARRLT---
------------------------------------------------TARRPPASSEQVQQELFNEMKPAVDGANFIVN
HMRDQNSYNEEKD-------------------------------------------------------------------
----------------------------------------------------------NWNQVARTVDRLCLFVVTPVMV
VGTAWIFLQGVYNQPPLQPFPGDPFSYSEQDKRFI---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Felis_catus_CHRND
-------------------------------------------------TARTPSWGVAGSPQLSPAPWPGRISRQPPSR
SPLPAPHPSSCPSP---GSWGLNE-------------------------------------------------EERLIRH
LFEE-KGYNKE-------------------------------------LRPVAHKDES----------------------
--VEVSLALTLSNLISLKE-------------------------------------------------------------
-----V--EETLTTNVWME-------------------------------------------------------------
----------------------------------------------HGWTDPR-LQWDAEE-------------------
--FGN---ISVLRLPPDMLWLPEIVLENN------NDGSFQIS-----YACNVLVYPSGYVYWLPPAIFRSSCP----IS
VT-------YFPFDWQNCSLKFSSLKYTAKE----ITLSLKQEE----------------KEGRSYPVEWIVIDPAGFT-
-ENGEWEIVHRPARINVDP-SV-------------------PLDSPGHQDVTFYLIIRR---------------------
--------------------KPLFYIINILVPCVLISFMINLVFYLPAD---S----------------GEKTSMA----
ISVLLAQSVFLLLI----------------------SKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFR-TP
STHV-LSEGVKKLF-------------LETLPKRLHMSRPAEDGPSPG--A-----------------------------
------------------LVRRSSSLGYISKAEEYFL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------LKSRSDLMFEKQSERHGLARRLT---
------------------------------------------------TARRPPAGSEQAQQELFSQLKPAVDGANFIVN
HMRDQNNYNEEKD-------------------------------------------------------------------
----------------------------------------------------------CWNRVARTVDRLCLFVVTPIMV
VGTAWIFLQGAYNQPPPQPFPGDPFSYHEKDKRFA---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Xenopus_tropicalis_CHRND
------------------------------------------------------------------------------HA
WLWLFDLLCILVLVP--GCLSESE-------------------------------------------------EERLLNH
IFGE-RGYRKE-------------------------------------LRPVEHTGET----------------------
--VNVSLALTLSNLISLKE-------------------------------------------------------------
-----A--DETLTTNVWVE-------------------------------------------------------------
----------------------------------------------LGWYDKR-LAWDMEE-------------------
--FHH---INIIRVPPDMVWQPQLILENN------NNGVFEVA-----YYSNVLVNSDGFMYWLPPAIFQTSCS----IN
VN-------YFPFDWQNCSLKFSSLTYNAKE----INLQLRQDQDE----ESQR-----N-----YPVEWIIIDPEGFT-
-ENGEWEIVHIPAKKNIDR-SL-------------------TPESTKYQDITFYLIIKR---------------------
--------------------KPLFYIINILAPCVLIALMANLVFYLPAD---S----------------GEKMTLA----
ISVLLAQSVFLLLI----------------------SQRLPETSFAIPLISKYLMFIMVLVTIVVVSCVIVLNLHFR-TP
STHV-ITERMKEIF-------------LNKLPRILHMSRPAEPEPEPWSGV-----------------------------
------------------LLRRSSSVGYIVKAEEYYS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------VKSRSELMFEKQSERHGLTSRAT---
------------------------------------------------PARVNPLNSNNSQDQLYGEIKPAIDGANFIVK
HMRDKNDYNEEKD-------------------------------------------------------------------
----------------------------------------------------------NWYRIARTVDRLCLFLVTPVMI
IGTLWIFLGGAYNLPPSLPFPGDPFDYNKEHKRLI---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRND_a
------------------------------------------------------------------------ARGCNLSR
GRNSAMHLRVCVCVS--GCWCRNE-------------------------------------------------EERLIHH
LFKE-LGYNKE-------------------------------------LRPVRRHEDA----------------------
--VDVQLALTLSNLISLKE-------------------------------------------------------------
-----V--DETLLTNVWIE-------------------------------------------------------------
----------------------------------------------HTWTDYR-LSWNLSA-------------------
--FDG---ISMLRLPSNMVWLPEIVLENN------NDAQFKVA-----YYSNVLVSSDGLCYWLPPAIFRSSCS----IS
VK-------YFPFDWQNCTLKFTSLTYNAKE----IRMLLKEDALN----------------GTAYTVEWIVIDPASFT-
-ENGEWEIIHRPAKRNTYK-HI-------------------PMESNKHQDITFYLVIRR---------------------
--------------------KPLFYVVNIIIPCVLISFLALLVYYLPAD---S----------------GEKMTLS----
ISVLLAQSVFLLLI----------------------SQRLPETSMSVPLIVKYLMFIMVGVTVVVLNCVVVLNLHFR-TP
STHV-MSGWTKRLF-------------LERLPRLLRMSRPAETEA-YWDGV-----------------------------
------------------LPRRSSSVGYIASAEEYYS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------VKSRSELMFEKQSERHGLVTRVT---
------------------------------------------------HAAMKPQDEGGVTDQLYAEIKPAVDGANYIIK
HMRNKNDYNEEKD-------------------------------------------------------------------
----------------------------------------------------------NWSGIARTVDRLCLFLVTPLMT
VGTVIIFTGI-CNQPPHLPFKGDPHDYREENPRLL---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRND_b
--------------------------------------------------------------------------------
-----------------GCWCRNE-------------------------------------------------EERLIHH
LFKE-LGYNKE-------------------------------------LRPVRRHEDA----------------------
--VDVQLALTLSNLISLKE-------------------------------------------------------------
-----V--DETLLTNVWIE-------------------------------------------------------------
----------------------------------------------HTWTDYR-LSWNLSA-------------------
--FDG---ISMLRLPSNMVWLPEIVLENN------NDAQFKVA-----YYSNVLVSSDGLCYWLPPAIFRSSCS----IS
VK-------YFPFDWQNCTLKFTSLTYNAKE----IRMLLKEDALN----------------GTAYTVEWIVIDPASFT-
-ENGEWEIIHRPAKRNTYK-HI-------------------PMESNKHQDITFYLVIRR---------------------
--------------------KPLFYVVNIIIPCVLISFLALLVYYLPAD---S----------------GEKMTLS----
ISVLLAQSVFLLLI----------------------SQRLQKH--PCLFLSSYLMFIMVGVTVVVLNCVVVLNLHFR-TP
STHV-MSGWTKRLF-------------LERLPRLLRMSRPAETEA-YWDGV-----------------------------
------------------LPRRSSSVGYIASAEEYYS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------VKSRSELMFEKQSERHGLVTRGR---
------------------------------------------------SDRSAVRRD-----------QAGCGRSNYIIK
HMRNKNDYNEEKD-------------------------------------------------------------------
----------------------------------------------------------NWSGIARTVDRLCLFLVTPLMT
VGTVIIFTGI-CNQPPHLPFKGDPHDYREENPRLL---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Ciona_savignyi_CHRND
--------------------------------------------------------------------------------
-------LHTGFILLVLAASAASV------------------------------------------LSEFQSSESRLMKR
LLNG---YNNQ-------------------------------------FRPYNVEYENK---------------------
--TLVSMGMTLSQIISVK--------------------------------------------------------------
-----EK-SQELTTSVYMT-------------------------------------------------------------
----------------------------------------------FDW-VDNRFSWDPEE-------------------
--YEG---ITIIRIPPYAIWSPRIVLQNS------IDGNFDVS-----VPVMALIKYTGEVQWIPPGLYKSTCT----IV
VA-------LFPFDWQNCTMVFRSATYDRSE----MEFGLSYGDSIYVDPEA-------------------------FK-
-ENGEWKIVQRPVRINSDSS------------------------DPTYQDVTFYLIIRR---------------------
--------------------KPQFYVINLIIPCILMSSLSCFVFYLPSVSC-------------------EKMTLS----
ISVLLGETVFLFLI----------------------AQRVPETSLAVPLIAGYLLFVMILVIISVISSVVVCNVHYRSNT
--THSMPDWVVWFFME-------------KLAPILRVERPSEEESGACSARPR----RCSSVS-----------------
------------ARKAMRQRKEWKS-PSEIMFDHQAS-------------------------------------------
-----------------------------------------------------------------------------RLG
FRR-----------------------------------------------------------------------------
----------------------------------------------------------RHVVNHYGMTEVNVASPEND--
-------------------------------------------------------------------FEPAAESINYIAN
QLKEENDSA-----------------------------------------------------------------------
------------------------------------------------------QSKDDWGYVALILDRILLWIYFAAFS
LGT-LFFFLQSTFAYYPEQ-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Caenorhabditis_elegans_CHRND
--------------------------------------------------------------------------------
MRTNRLSWILVLSVVIFLVIIN--------------------------------------------TINASDDEERLMVD
VFRG---YNSL-------------------------------------IQPVRNSSELP---------------------
--LIVKMALQLVLLINVD--------------------------------------------------------------
-----EK-DQVMHTNVWLT-------------------------------------------------------------
----------------------------------------------LQWHDFQ-MKWNPVN-------------------
--YGE---IKQIRVSPDKVWLPDIVLFNN------ADGNYEVS-----FMCNVVINHKGDMLWVPPAIYKSSCI----ID
VE-------FFPFDEQVCTLVFGSWTYNENE----IKLEFVQ-AE--------------------------LVDVSEYS-
-ASSIWDVIDVPASLVNKRSR-----------------------------IEFQVRIRR---------------------
--------------------KTLFYTVVLIIPTVLMAFLSMAVFFLPTDSG-------------------EKITLT----
ISVLLSIVVFLLLV----------------------SKILPPTSSTIPLMAKYLLLTFVLNVITILVTVIIINVYFRGPR
-THR-MPQWVRVVFLQ-------------FLPKLVCMKRPKSASERSAVRSG----------------------------
------------MAQLP-------GVGQFTLSP-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------SAHHPLCPSADDRTTT---
-------------------------------------------------IRNTASNETSAYYPLSTDALRAIDAIEYITE
HLKRDEQ-------------------------------------------------------------------------
----------------------------------------------------HKSFRDDWKYVAMIIDRLLLYVFFGITV
GGT-CGILFSAPHVFQRIDQQEMLDRLKEKYDTASNIP------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNA1
--------------------------------------------------------------------------------
-----MEPWPLLLLFSLCSAG---------------------------------------------LVLGSEHETRLVAK
LFKD---YSSV-------------------------------------VRPVEDHRQV----------------------
--VEVTVGLQLIQLINVD--------------------------------------------------------------
-----EV-NQIVTTNVRLKQGDMVDLPRPSCV------------------------------------------------
----------------------------------TLGVPLFSHLQNEQWVDYN-LKWNPDD-------------------
--YGG---VKKIHIPSEKIWRPDLVLYNN------ADGDFAIV-----KFTKVLLQYTGHITWTPPAIFKSYCE----II
VT-------HFPFDEQNCSMKLGTWTYDGSV----VAINPESDQ----------------------------PDLSNFM-
-ESGEWVIKESRGWKHSVTYSC--------------------CPDTPYLDITYHFVMQR---------------------
--------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THV-MPNWVRKVFID-------------TIPNIMFFST-----------------------------------------
----------------------MKRPSREKQDKK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------IFTEDIDISDISGKPGPPPMGFHS---
------------------------------------------------------------PLIKHPEVKSAIEGIKYIAE
TMKSDQE-------------------------------------------------------------------------
----------------------------------------------------SNNAAAEWKYVAMVMDHILLGVFMLVCI
IGT-LAVFAGRLIELNQQG-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Pan_troglodytes_CHRNA1
--------------------------------------------------------------------------------
-----MEPWPLLLLFSFCSAG---------------------------------------------LVLGSEHETRLVAK
LFKD---YSSV-------------------------------------VRPVEDHRQV----------------------
--VEVTVGLQLIQLINVD--------------------------------------------------------------
-----EV-NQIVTTNVRLKQGDMVDLPRPSCV------------------------------------------------
----------------------------------ILGVPLFSHLQNEQWVDYN-LKWNPDD-------------------
--YGG---VKKIHIPSEKIWRPDLVLYNN------ADGDFAIV-----KFTKVLLEYTGHITWTPPAIFKSYCE----II
VT-------HFPFDEQNCSMKLGTWTYDGSV----VAINPESDQ----------------------------PDLSNFM-
-ESGEWVIKESRGWKHSVTYSC--------------------CPDTPYLDITYHFVMQR---------------------
--------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIIINTHHRSPS
-THV-MPNWVRKVFID-------------TIPNIMFFST-----------------------------------------
----------------------MKRPSREKQDKK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------IFTEDIDISDISGKPGPPPMGFHS---
------------------------------------------------------------PLIKHPEVKSAIEGIKSTTV
TMKSDQE-------------------------------------------------------------------------
----------------------------------------------------SNYAAAEWKYVAMVMDHILLGVFMLVCI
IGT-LAVFAGRLIELNQQG-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Felis_catus_CHRNA1
------------------------------------------------------------------------------MR
VFVEGGEQNLTVCVSFAVSAG---------------------------------------------LVLGSEHETRLVAK
LFED---YNSV-------------------------------------VRPVEDHRQA----------------------
--VEVTVGLQLIQLINVD--------------------------------------------------------------
-----EV-NQIVTTNVRLKQ------------------------------------------------------------
-----------------------------------------------QWVDYN-LKWNPED-------------------
--YGG---VKKIHVPSEKIWRPDFVLYNN------ADGDFAIV-----KFTKVLLDYTGHITWTPPAIFKSYCE----II
VT-------HFPFDEQNCSMKLGTWTYDGSV----VAINPESDQ----------------------------PDLSNFM-
-ESGEWVIKESRGWKHWVFYAC--------------------CPTTPYLDITYHFVMQR---------------------
--------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THV-MPNWVRKVFID-------------TIPNIMFFST-----------------------------------------
----------------------MKRPSREKQDKK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------IFTEDIDISDISGKPGPPPMGFHS---
------------------------------------------------------------PLIKHPEVKSAIEGVKYIAE
TMKSDQE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKYVAMVMDHILLGVFMLVCI
IGT-LAVFAERMKTMVRITPPAPQS-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Anolis_carolinensis_CHRNA1
--------------------------------------------------------------------------------
-----MDVCCLPLLLLLGPAV---------------------------------------------LVRCSSHETRLVSD
LFSK---YNKV-------------------------------------VRPVSNHRDP----------------------
--VRVTVGLQLIQLINVD--------------------------------------------------------------
-----EV-NQIVTTNVRLKQ------------------------------------------------------------
-----------------------------------------------QWMDVN-LKWNPED-------------------
--YGG---VKQIRIPSEDIWRPDLVLYNN------ADGDFAIN-----KFTKILLNYTGHITWTPPAIFKSYCE----II
VT-------HFPFDEQNCSMKLGTWTYDGTM----VVINPESDR----------------------------PDLSNYM-
-GSGEWIMKDYRGWKHEVTYAC--------------------CPDLPYLDITYHFVMLR---------------------
--------------------LPLYFIVNVIIPCLLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRNPS
-THT-MPQWVRKIFID-------------TIPNLMFFST-----------------------------------------
----------------------MKRPSKNKQEKK----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------IFSEDIDISEISGKQGPATVNFQS---
------------------------------------------------------------SLIKNPEVKSAIEGIKYIAE
TMKSDQE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVVDHLLLGIFMSVCI
IGT-LAVFAGRLIELHQQG-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNA1_a
--------------------------------------------------------------------------------
------MNYFILILPILPYLYG--------------------------------------------PAVCSEDETRLVKT
LFTG---YNKV-------------------------------------VRPVSHFKDP----------------------
--VVVTVGLQLIQLISVD--------------------------------------------------------------
-----EV-NQIVTSNVRLKQ------------------------------------------------------------
-----------------------------------------------QWKDVH-LQWNPDD-------------------
--YGG---IRKIRIPSTDLWKPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWTPPAIFKSYCE----IV
VL-------HFPFDLQNCSMKLGTWTYDGNL----VIINPDSDR----------------------------PDLSNFM-
-ESGEWVMKDYRSWKHWVYYAC--------------------CPDTPYLDITYHFLLLR---------------------
--------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMIFVIASIIITVIVINTHHRSPS
-THI-MPAWVRKIFID-------------TIPNMMFFST-----------------------------------------
----------------------MKRPSQERQEKR----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------LFPADFDISDISGKPMPASVTYHS---
------------------------------------------------------------PITKNPDVRSAIEGVKYIAD
TMKSDEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI
IGT-LGVFAGRLIELSML--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNA1_a
--------------------------------------------------------------------------------
--------LHLCDFSSGVETLA--------------------------------------------GTCASEDETRLVKT
LFTG---YNKV-------------------------------------VRPVNHFSEP----------------------
--VVVTVGLQLIQLISVD--------------------------------------------------------------
-----EV-NQIVTSNVRLRQ------------------------------------------------------------
-----------------------------------------------QWVDVN-LNWNPDD-------------------
--YGG---IRKIRVPSTDIWKPDLVLYNN------ADGDFAII-----HETKVLLEHTGKIIWNPPAIFKSYCE----II
VL-------HFPFDLQNCSMKLGTWTYDGLL----VVINPDSDR----------------------------PDLSNFM-
-ESGEWVLKDYRSWKHWVYYTC--------------------CPDTPYLDITYHFLMLR---------------------
--------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THT-MPPWIRKVFIE-------------TIPNMMFFST-----------------------------------------
----------------------MKRPSQEIRQKR----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------LFPTDMDISDISGNPTPTSVTYQS---
------------------------------------------------------------PIVKNPDVRSAIEGVKYIAE
TMKSDEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI
IGT-LAVFAGRLIELN----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNA1_a
---------------------------------------------------------------------------FTLRV
SGGSLWFRAHLPERSQHFSRSP---------------------------------------------VLCSEDETRLVKT
LFTG---YNKV-------------------------------------VRPVNHFSEP----------------------
--VVVTVGLQLIQLINVD--------------------------------------------------------------
-----EV-SQIVTSNVRLRQ------------------------------------------------------------
-----------------------------------------------QWVDVN-LNWNPDD-------------------
--YGG---IRKIRVPSSEIWKPDLVLYNN------ADGDFAII-----HETKVLLEHTGKIIWNPPAIFKSYCE----II
VL-------HFPFDVQNCSMKLGTWTYDGLL----VVINPDSDR----------------------------PDLSNFM-
-ESGEWVLKDYRSWKHWVYYTC--------------------CGDTPYLDITYHFLMQR---------------------
--------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THT-MPPWIRKVFIE-------------TIPNMMFFST-----------------------------------------
----------------------MKCPSQEIRQKR----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------LFPTDMDISDISGNPTPTSVTYQS---
------------------------------------------------------------PIVKNPDVRSAIEGVKYIAE
TMKADEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI
IGT-VAVFAGRLIELNMP--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNA1_b
--------------------------------------------------------------------------------
------MNTTLFSFHII-LLAG--------------------------------------------AAWASSNETRLVKN
LFAG---YNKV-------------------------------------VRPVTHFKDP----------------------
--VVVTVGLQLIQLINVD--------------------------------------------------------------
-----EV-NQIVSSNVRLKQ------------------------------------------------------------
-----------------------------------------------QWKDVN-LHWNPDD-------------------
--YGG---IKKIRVPSTDIWRPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWNPPAIFKSYCE----II
VL-------HFPFDLQNCSMKLGTWTYDGNL----VVVNPDSDR----------------------------PDLSNFM-
-ESGEWVMKDYRGWKHWVYYAC--------------------CPDTPYLDITYHFLMLR---------------------
--------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THT-MPDWVRRIFIE-------------TIPNIMFFST-----------------------------------------
----------------------MKRPGKEKQRKG----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------IQPPDFDISEISGN-QATAVPYET---
------------------------------------------------------------RITKNPDVRSAIEGVKYIAE
TMKSDEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCL
VGT-LGVFAGRLIELSML--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNA1_a
--------------------------------------------------------------------------------
---------------------P---------------------------------------------VSCSEAETRLVKK
LFTG---YSKV-------------------------------------VRPVDHFSDA----------------------
--VVVSVGLQLIQLISVD--------------------------------------------------------------
-----EV-NQIVTSNVRLKQ------------------------------------------------------------
-----------------------------------------------RWRDVN-LNWDPDD-------------------
--YGG---IRKIRVPSTDIWKPDLVLYNN------ADGDFAII-----HQTKVLLEHTGMITWNPPAIFKSYCE----II
VL-------HFPFDLQNCSMKLGTWTYDGLL----VVINPDSAR----------------------------PDLSNFM-
-ESGEWVLKDYRSWKHTVNYSC--------------------CPNKPYLDITYHFLMLR---------------------
--------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THT-MPAWIRKVFIE-------------TIPNMMFFST-----------------------------------------
----------------------MKRPSLEIRQMR----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------MFPTDMDISDISGNPAPTSDTYVS---
------------------------------------------------------------PITKNPDVRRAIEGVKYIAE
TMKSDEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCI
IGT-LAVFAGRLIELNTL--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNA1_b
--------------------------------------------------------------------------------
---MARMKPVFFIFYLV-ILAG--------------------------------------------AAWGSSDETRLVKT
LFTG---YNKV-------------------------------------VRPVNHFKDP----------------------
--VVVTVGLQLIQLISVD--------------------------------------------------------------
-----EV-NQIVSSNVRLKQ------------------------------------------------------------
-----------------------------------------------QWKDVN-LQWKPED-------------------
--YSG---IKKIRVPSTDIWRPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWNPPAIFKSYCE----II
VL-------HFPFDLQNCSMKLGTWTYDGNL----VVVNPDSER----------------------------PDLSNFM-
-ESGEWVMKDFRGWKHWVYYAC--------------------CPDTPYLDITYHFLMLR---------------------
--------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THT-MPNWVRTVFIE-------------TIPNIMFFST-----------------------------------------
----------------------MKRPGKEKQAKSS---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------IYGADFDISDISGN-QTTSITYQS---
------------------------------------------------------------PITKNPDVRSAIEGVKYIAE
TMKSDEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMAVCL
IGT-LGVFAGRLIELSML--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNA1_a
-------------------------------------------------------------------------------L
GFTMYKYILKVLILFSDCCSRS---------------------------------------------VLGSEYETRLVKT
LFTG---YNKV-------------------------------------VRPVTHFSQA----------------------
--VEVTVGLQLIQLISVD--------------------------------------------------------------
-----EV-NQIVTSNVRVKQ------------------------------------------------------------
-----------------------------------------------QWTDVN-LKWNPDD-------------------
--YGG---IKKIRVPSTDIWKPDLVLYNN------ADGDFAII-----HETKVLLEYSGKITWNPPAIFKSYCE----II
VL-------HFPFDLQNCSMKLGIWSYDGLL----VVINPESDK----------------------------PDLSNFM-
-ESGEWVLKDSRCWKHWVQYTC--------------------CQDTPYLDITYHFLMLR---------------------
--------------------LPLYFIVNVIIPCLLFSFLTALVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINVHHRSPS
-THT-MPQWIRKVFIE-------------TIPNMMVFST-----------------------------------------
----------------------MKRPGQEIRQRR----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------FFPTDMDISDISGNLPPTSITYQS---
------------------------------------------------------------PIIKNPDVRSAIEGVKHIAE
TMKLDEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMGVCI
IGT-VAVFAGRLIELNM---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNA1_b
--------------------------------------------------------------------------------
------MGTLFFAFQVI-ILAG--------------------------------------------AAFASSDETRLVKT
LFTG---YNKV-------------------------------------VRPVNHYKDP----------------------
--VVVTVGLQLIQLISVD--------------------------------------------------------------
-----EV-NQIVSSNVRLKQ------------------------------------------------------------
-----------------------------------------------QWKDVN-LQWNPED-------------------
--YGG---IRKIRVPSTDIWRPDLVLYNN------ADGDFAIV-----HETKVLLEHTGMITWNPPAIFKSYCE----II
VL-------HFPFDLQNCTMKLGTWTYDGNL----VVVNPDSDR----------------------------PDLSNFM-
-ESGEWVMKDYRGWKHWVYYAC--------------------CQDTPYLDITYHFLMLR---------------------
--------------------LPLYFIVNVIIPCMLFSFLTGLVFYLPTDSG-------------------EKMTLS----
ISVLLSLTVFLLVI----------------------VELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS
-THT-MPDWVRKVFIE-------------TIPNLMFFST-----------------------------------------
----------------------MKRPAKEKQNKP----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------VYTAEFDISEISGN-QATAVHYQS---
------------------------------------------------------------PLTKNPDVRSAIEGVKYIAE
TMKSDEE-------------------------------------------------------------------------
----------------------------------------------------SNNAAEEWKFVAMVLDHILLCVFMGVCL
IGT-LGVFAGRLIELSTY--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNA2
----------------------------------------------------------------------------MGPS
CPVFLSFTKLSLWWLLLTPAG---GEEAKRPPPRAPGDP----------------LSSPSPTALPQGGSHTETEDRLFKH
LFRG---YNRW-------------------------------------ARPVPNTSDV----------------------
--VIVRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWSDYK-LRWNPTD-------------------
--FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFSTGTVHWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMEQT----------------------------VDLKDYW-
-ESGEWAIVNATGTYNSKKYDC--------------------C-AEIYPDVTYAFVIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THT-MPHWVRGALLG-------------CVPRWLLMNRPP---------------------------------------
-------------PPVE----LCHPLRLKLSPSYH---------------WLESN-------------------------
--------VDAE------------------------------------------------------------------ER
EVVVEE-----------------------------------------------------EDR-----------------W
ACAGHVAPSVGTL-----------------------------------------CSHGHLHSGASG-------PKAEA--
-------------------------------------------------------LLQEGELLLSPHMQKALEGVHYIAD
HLRSEDA-------------------------------------------------------------------------
----------------------------------------------------DSSVKEDWKYVAMVIDRIFLWLFIIVCF
LGT-IGLFLPPFLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Macaca_mulatta_CHRNA2
----------------------------------------------------------------------------MGPS
RPAFLSFTKLSLWWLLLTPAG---GEEAKRPPPRAPGDP----------------LSSPSPTALPQGGSHTQAEDRLFKH
LFRG---YNRW-------------------------------------ARPVPNTSDV----------------------
--VIVRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWSDYK-LRWNPAD-------------------
--FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFSTGTVHWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMEQT----------------------------VDLKDYW-
-ESGEWAIVNATGTYNSKKYDC--------------------C-AEIYPDVTYAFVIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THT-MPRWVRGALLG-------------CVPRWLLMNRPL---------------------------------------
-------------PSLE----LCHPPGLKLSPSYH---------------WLETN-------------------------
--------MDAE------------------------------------------------------------------ER
EVVVEE-----------------------------------------------------EDR-----------------W
ACAGHVASSVGTL-----------------------------------------CSHGHLHSGASG-------PKAEA--
-------------------------------------------------------VLQEGELLLSPRMQKALEGVHYIAD
HLRSEDA-------------------------------------------------------------------------
----------------------------------------------------DSSVKEDWKYVAMVIDRIFLWLFIIVCF
LGT-IGLFLPPFLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRNA2
----------------------------------------------------------------------------MAPS
HPAFQFWIHLYLWCLLLMPAV------------------------------------------LAQQGSHTHAEDRLFKH
LFGG---YNRW-------------------------------------ARPVPNTSDV----------------------
--VIVRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWDPAE-------------------
--FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFFTGTVHWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMERT----------------------------VDLKDYW-
-ESGEWAIINATGTYNSKKYDC--------------------C-AEIYPDVTYYFVIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THN-MPNWVRVALLG-------------RVPRWLMMNRPL---------------------------------------
-------------PPME----LHGSPGLKLSPTYH---------------WLETN-------------------------
--------MDAE------------------------------------------------------------------ER
EETEEEEE-----------------------------------------------EEEDENI-----------------C
MCAGLPDSSMGVL-----------------------------------------YGHGSLHLRAMG-------PEAKT--
-------------------------------------------------------PSQASEILLSPQIQKALEGVHYIAD
HLRSEDA-------------------------------------------------------------------------
----------------------------------------------------DSSVKEDWKYVAMVVDRIFLWLFIIVCF
LGT-IGLFLPPFLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Felis_catus_CHRNA2
----------------------------------------------------------------------------MGPS
RSAVLSAMRLGLWWLLLSPADL--MGE--GPKHPPPWTP----------------GDPTLPS-CPQGASRTQAEDRLFKH
LFRG---YNRW-------------------------------------ARPVPNTSDV----------------------
--VIVRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LHWNPAD-------------------
--FGN---ITSLRVPSEMIWIPDIVLYNN------ADGEFAVT-----HMTKAHLFSTGTVHWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQTEQT----------------------------VDLKDYW-
-ESGEWAIINATGTYNTKKYDC--------------------C-AEIYPDVTYYFVIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TDIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR
-THT-MPHWVRVAFLG-------------CVPRWLLMNRPV---------------------------------------
-------------PPLE----PRDPPDLKPSSSHY---------------WLETN-------------------------
--------VDAE------------------------------------------------------------------ER
EEE--K---------------------------------------------------EEEDR-----------------W
GWAAHVSPSMGVL-----------------------------------------HGHGGLHQGASG-------PRVEV--
-------------------------------------------------------QLQEGGLLLSPRIQKALEGVHYIAD
HLRSEDA-------------------------------------------------------------------------
----------------------------------------------------DSSVKEDWKYVAMVIDRIFLWLFIIVCF
LGT-IGLFLPPFLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Monodelphis_domestica_CHRNA2
-----------------------------------------------------------------------------LTM
PPPPLKMSDVDVFVLR--------------------------------------------------HASHALDEDRLFKK
LFRG---YNRW-------------------------------------SRPVQNSSDV----------------------
--VIIRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWSDYK-LRWNPTD-------------------
--YGN---ITSIRVPSELIWIPDIVLYNN------ADGEFIVT-----HMTKAHLFFTGTVKWAPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQMEQM----------------------------VDLKDYW-
-ESGEWAIINAVGTYNTKKYDC--------------------C-VEIYPDITYFFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPG
-THN-MPHWVRVAFLG-------------CIPRWLWMNRPL---------------------------------------
-------------PVLE----FHDNPGQKLSSTHH---------------WLDTN-------------------------
--------VDED------------------------------------------------------------------KK
S----------------------------------------------------------EEN-----------------W
EFSGHSSPVIDTL-----------------------------------------YHHCGHHHESPC-------FKAGT--
-------------------------------------------------------QLPETEFLLPPSIQKALEGVHYIAD
HLRTEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIICF
LGT-IGLFLPPLLA------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNA2_a
-----------------------------------------------------------------------------MAE
NRIKTLLNNLWMLILIADHVQ----------------------------------------PVLSDGWIHAHAEDKLFHK
LFIG---YNKW-------------------------------------SRPVRNISDV----------------------
--VIVKFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWNPSE-------------------
--FDN---VTSIRVPSEMIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHTGKVSWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLEQIEGT----------------------------VDLKDYW-
-ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THS-MPRWVHSVFLD-------------HIPRWLFMRRPE---------------------------------------
-------------PEKKP---KKTANLSTSKSWFQQET------------GVDGLV------------------------
--------CQDMEF------------------------------------------------------------GIGLST
SISSPSATSL------------------------------------------------HLSD------------------
SEPLLQKYELQHLG-------------------------------------------HVVNLCQHP-------AKLGN--
-------------------------------------------------------LVSEPGLLFSPCVLRALEGVRYIAD
HLRAEDE-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-IGLFLPPWLSGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNA2_b
-------------------------------------------------------------------------------M
ASFTNQLVFLRITLLCTIICE----------------------------------------SISCCEKTHSHAEDELFKK
LFDG---YNKW-------------------------------------SRPVPNTSDV----------------------
--VIVKFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWKPSD-------------------
--YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHTGKVRWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERIENT----------------------------VDLKDYW-
-ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THK-MPCWVHSVFLD-------------LIPRWLFMRRPA---------------------------------------
-------------PDSR----RRQKLLLLQRQVPG----------------MTARP------------------------
--------ANAS-----------------------------------------------------------------LST
STSWFRGQNS------------------------------------------------GEDES----------------C
RHFSYKDLELGTLSSAISLSLQASSPCPLGLTPPPLQKFGPAPRLEVG------TASRQLSGRANV-------TKRLDNM
------------------------------------------------------IPHDNPGFPLSPSVLQALEGVHYIAD
HLRAEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-IGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNA2_a
-----------------------------------------------------------------------------MKK
LQSFTLCFTCHLIVLCIRSVS----------------------------------------AVLCSQKTHSHAEDDLFKK
LFAG---YNKY-------------------------------------SRPVPNVTDV----------------------
--VIVKFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWRPSD-------------------
--YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFYNGKILWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERIENT----------------------------VDLNNYW-
-ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THK-MPRWVHSVFLD-------------LIPRWLFMRRPA---------------------------------------
-------------PDGR----RRRLLLLQQEVMAE---------------RRRGRL------------------------
--------TGYKS-------------------------------------------------------------GNYLST
SANWLMDGSL------------------------------------------------SDEP------------------
NRNSYEDLELG----------------------------------------------RARITAQRL-------TKADS--
-------------------------------------------------------TVSDSSFLLSPSIIRALEGVHYIAD
HLRAEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-IGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNA2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------VLCSQKMHSHSEDALFKK
LFAG---YNKY-------------------------------------SRPVPNVTDV----------------------
--VIVKFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWRPSD-------------------
--YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHNGKIRWVPPAIYNSSCI----ID
VT-------FFPFDQHTARCKFGPCRYDKA-------------------------------------------KLTCYW-
-ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THK-MPRWVHSVFLD-------------LIPRWLFMRRPA---------------------------------------
-------------PEGR----RRRLLLLQQPPSPRPLG------------TSPPRQ------------------------
--------QNSQK-------------------------------------------------------------KQEVPA
GTNQQLSG------------------------------------------------------------------------
----------------------------------------------------------ARTTAQRL-------TKADS--
-------------------------------------------------------TGSDSYFLLSPSIIRALEGVHYIAD
HLRAEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-IGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNA2_a
--------------------------------------------------------------------------------
-----YTIKYEPLRMILFNVS----------------------------------------AVLCHEKSHSHAEDDLFKT
LFAG---YNKW-------------------------------------SRPVSNISDV----------------------
--VIVKFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWKPSD-------------------
--YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHNGKVRWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERTENT----------------------------VDLNNYW-
-ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THK-MPHWVHSVFLN-------------LIPRWLFMRRPA---------------------------------------
-------------PDVR----RRRLALMQQDAALV---------------RRQGRA------------------------
--------GGYKRP------------------------------------------------------------SNCLST
SATWSGG-------------------------------------------------------------------------
---------------------------------------------------------SRVNLTQRA-------VKADN--
-------------------------------------------------------AVSDSTFLLSPSVIRALEGVHYIAD
HLRAEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-IGLFLPPWLA------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNA2_a
--------------------------------------------------------------------------------
---------------------------------------------------------------FCYDKSHAHAEEELFQT
LFTG---YNKW-------------------------------------SRPVPNISDV----------------------
--VIVKFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWKPSD-------------------
--YDN---VTSIRVPSELIWVPDIVLYNN------ADGEFAVT-----HMTKAHLFHTGKVRWVPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDKAK----IDLERIENT----------------------------VDLNNYW-
-ESGEWAIINAVGTYNTKKYDC--------------------C-HEIYPDITYFFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPS
-THK-MPRWVHTVFLD-------------LIPRWLFMRRPA---------------------------------------
-------------PNGR----RRRLLLLQQDGALG---------------RLQPRV------------------------
--------SALD-----------------------------------------------------------------IST
SSTWLREGAV------------------------------------------------LEKT------------------
ERSCYEDLELGTLQSYFSFRPPSPRPPGQTPPQQLKTPQNSQSWREG---------GGGPNRQMGG-------ARVDSPK
------------------------------------------------------VQCAESGSLLSPCVMRALEGVHYIAD
HLRAEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-IGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Branchiostoma_floridae_CHRNA2
--------------------------------------------------------------------------------
--------------------------------------------------------------MFLPGGVATQSEERLFRD
LFRD---YNKW-------------------------------------IRPVANISNI----------------------
--VVIEFGLAIAQLLDVD--------------------------------------------------------------
-----EK-NQIMTTNVWLK-------------------------------------------------------------
----------------------------------------------QKWKDSK-LCWDPDE-------------------
--YHG---VSVIRVPSDMIWLPDIVLYNN------ADGNYAVK-----HNTKAQISSDGMVTWEPPAVYKSSCE----IE
VT-------YFPFDQQNCSMKFGSWTYDGFQ----IDLMMMDDH----------------------------VDQGGFS-
-ESGEWVIIDAPGQKNIIKYEC--------------------C-EEVYPDITFFFVIRR---------------------
--------------------LPLFYTINLIVPCALISFLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPATSIVIPVIGEYLLFTMIFVTLSIVITVFVLNIHYRSPS
-THR-MPVWVRKIFID-------------ILPRLLSDVYDY---------------------------------------
---------------------ESKTLPRMTTPKMR---------------------------------------------
----------SR-----------------------------------------------------------------HGA
KVSVTNVSG-----------------------------------------------------------------------
------NPGVGG------------------------------------------AEKYNTCDSRPS--------QSQA--
-------------------------------------------------------RAQFQSYQYSPDILRAAQGVNYIAE
TLRAKDE-------------------------------------------------------------------------
----------------------------------------------------ADSVNEDWKYVAMVIDRIFLWIFVSMCI
LGT-IGLFLQP-LPGFIS--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Drosophila_melanogaster_CHRNA2
--------------------------------------------------------------------------------
----MGSVLFAAVFIALHFATGG---------------------------------------------LANPDAKRLYDD
LLSN---YNRL-------------------------------------IRPVGNNSDR----------------------
--LTVKMGLRLSQLIDVN--------------------------------------------------------------
-----LK-NQIMTTNVWVE-------------------------------------------------------------
----------------------------------------------QEWNDYK-LKWNPDD-------------------
--YGG---VDTLHVPSEHIWLPDIVLYNN------ADGNYEVT-----IMTKAILHHTGKVVWKPPAIYKSFCE----ID
VE-------YFPFDEQTCFMKFGSWTYDG------YMVDLRHLK-----------------QTADSDNIEVGIDLQDYY-
-ISVEWDIMRVPAVRNEKFYS---------------------CCEEPYLDIVFNLTLRR---------------------
--------------------KTLFYTVNLIIPCVGISFLSVLVFYLPSDSG-------------------EKISLC----
ISILLSLTVFFLLL----------------------AEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPV
-THR-MAPWVQRLFI--Q-----------ILPKLLCIERPKKE-EP---------------EEDQPPEVLTDVYHLPPDV
DKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAH-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------CFAEPPLPSSLPLPGADDDLFSPSGL
------------------------------------NGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQ
HVKNKDKFE-----------------------------------------------------------------------
------------------------------------------------------SVEEDWKYVAMVLDRMFLWIFAIACV
VGT-ALIILQAPSLYDQSQPID--ILYSKIAKKKFELLKMGSENTL----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Apis_mellifera_CHRNA2
-------------------------------------------------------------------------------M
FKMQILTLGVLFNTLHIIYSVAGLKI-----------------------------------------FEANPDTKRLYDD
LLSN---YNRL-------------------------------------IRPVMNNTET----------------------
--LTVQLGLKLSQLIEMN--------------------------------------------------------------
-----LK-NQVMTTNVWVE-------------------------------------------------------------
----------------------------------------------QRWNDYK-LKWNPEE-------------------
--YGG---VEMLYVPSENIWLPDIVLYNN------ADGNYEVT-----LMTKATLKYTGDVSWKPPAIYKSSCE----IN
VE-------YFPFDEQSCIMKFGSWTYNG------AQVDLKHMK-----------------QEAGSNLVAKGIDLSDFY-
-LSVEWDILEVPASRNEEYYP---------------------CCTEPYSDITFNITMRR---------------------
--------------------KTLFYTVNLIIPCVGITFLTVLVFYLPSDSG-------------------EKVSLC----
SSILLSLTVFFLLL----------------------AEIIPPTSLAIPLLGKYLLFTMILVTLSIWITVCVLNVHFRSPS
-THN-MSPWVRQVFL--N-----------WMPRLLMMRRTPYSTPEYD--------------------------------
--------------------DTYMDSGYTNEIDFSFP-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------DSVSDYPLELKGSPDGFESVTSQYK-
--------------------------------------NIREDDARHIPHASVTDSENTVPRYLSPDVISALKGVRFIAQ
HIKNADKDN-----------------------------------------------------------------------
------------------------------------------------------EVIEDWKFVAMVLDRLFLWVFTLACT
AGT-LGIIFQAPSLYDTREPVD--QQLSGISPR--NYMYPNIDISPEG--------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Anopheles_gambiae_CHRNA2
--------------------------------------------------------------------------------
----MGSVLLTAVFIALQFATG----------------------------------------------LANPDSKRLYDD
LLSN---YNRL-------------------------------------IRPVGNNSDR----------------------
--LTVKMGLRLSQLIDVN--------------------------------------------------------------
-----LK-NQIMTTNVWVE-------------------------------------------------------------
----------------------------------------------QEWNDYK-LKWNPDD-------------------
--YGG---VDTLHVPSEHIWLPDIVLYNN------ADGNYEVT-----IMTKAILHHTGKVVWKPPAIYKSFCE----ID
VE-------YFPFDEQTCFMKFGSWTYDG------YMVDLRHLQ-----------------QTPDSDNIDIGIDLQDYY-
-ISVEWDIMKVPAVRNEKFYS---------------------CCEEPYPDIIFNITLRR---------------------
--------------------KTLFYTVNLIIPCVGISFLSVLVFYLPSDSG-------------------EKISLC----
ISILLSLTVFFLLL----------------------AEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPV
-THR-MAPWVHRVFI--E-----------LLPKVLCIERPKKEDEPSD------------NDDQTPTDVLTDVFQVPPDV
EKYVGFCGKEYGTDFDIPALPPS-RFDVAASGGVGP--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------CFGEPPLP-ALPLPGGDDDLFSPTG-
------------------------------------NGDMSPTCC--------GDLSPTFEKPLLREMEKTIEASRFVAQ
HVRNKDKFE-----------------------------------------------------------------------
------------------------------------------------------SVKEDWKYVALVLDRLFLWIFTIACV
LGT-CLIILQAPSLYDNTQPID--AMYSKIAKKKMELLKMGSENV-----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Amphimedon_queenslandica_CHRNA2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------MSSSRSLSSS----------------------
-----RSKSHLSKSSKFES-------------------------------------------------------------
--------TAELPSEVMVN-------------------------------------------------------------
--------------------------------------------------TPEQLSWQVLS-------------------
----------QTQVARFKALSPTELTKEL-------STVLSLS-----KHEEDLQQAAILDYYVSSFVFAQEKD------
------------FTDEQLSSFFTIIHKLLAN--------IREKR----------------------------TTLQDNLN
ELKSYFAGVGVSDQTCLKCFTP------------------------KVAMATISYIHTS---------------------
----------------------------------LVQHYTLFEYILQEKQE-------------------DEFIQT----
-----QLLVSLP---------------------------PDSSTLSPPPLEESVTEDFYNRLVSTAPAGSPSQTQLGSPT
-THS-PPHSIQGTDMSSPTG---------AIPPTLLLNLRP---------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------EDVKMMTE
KLLEETVTP-----------------------------------------------------------------------
-------------------------------------------------------------YQDEMLRKLVDRETSYKSK
LDKLEKSLT-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNA6
---------------------------------------------------------------------MLTSKGQGFLH
----GG---LCLWLCVFT--PFF------------------------------------------KGCVGCATEERLFHK
LFSH---YNQF-------------------------------------IRPVENVSDP----------------------
--VTVHFEVAITQLANVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWDPME-------------------
--YDG---IETLRVPADKIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYNGMITWTPPAIFKSSCP----MD
IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW-
-ENSEWEIIDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR---------------------
--------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPT
-THT-MPRWVKTVFLK-------------LLPQVLLMRWPLD--------------------------------------
------------KTRGTGSDAVPRG---LARRPAKGK-------------------------------------------
-----------------------------------------------------------------------------LAS
HGEPRHL------------------------------------------------------------------------K
ECFHCHKSN-------------------------------------------ELATS-KRRLSHQPLQWVVENSEHS---
-----------------------------------------------------------------PEVEDVINSVQFIAE
NMKSHNE-------------------------------------------------------------------------
----------------------------------------------------TKEVEDDWKYVAMVVDRVFLWVFIIVCV
FGT-AGLFLQPLLGNTGKS-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Pongo_abelii_CHRNA6
---------------------------------------------------------------------MPTSKGQGFLH
----GG---LCLWLCVFT--PFF------------------------------------------KGCAGCVTEERLFHK
LFSH---YNQF-------------------------------------IRPVENVSDP----------------------
--VTVHFEVAITQLANVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWDPTE-------------------
--YDG---IETLRVPADKIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYNGMITWTPPAIFKSSCP----MD
IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW-
-ENSEWEIIDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR---------------------
--------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVVPLVGEYLLFTMIFVTLSIMVTVFVLNIHYRTPT
-MHT-MPRWVKTVFLK-------------LLPQVLLMRWPVD--------------------------------------
------------KTRGTGSDAMPRG---LARRPAKGK-------------------------------------------
-----------------------------------------------------------------------------LAS
REEPRHL------------------------------------------------------------------------K
ECFHCHKSN-------------------------------------------ELATS-KRRLSHQPLQWMVENSEHS---
-----------------------------------------------------------------PEVEDVINSVQFIAE
NMKSHNE-------------------------------------------------------------------------
----------------------------------------------------TKQVEDDWKYVAMVVDRVFLWVFIIVCV
FGT-AGLFLQPLLGNTGKS-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRNA6
---------------------------------------------------------------------MLNSRDQGNLH
----SG---LCLWLCGFL--ALF------------------------------------------KGSTGCESEEQLFHR
LFAH---YNRF-------------------------------------IRPVENVSDP----------------------
--VTVHFELAITQLANVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWKDYR-LRWDPTE-------------------
--YDG---IETLRVPADNIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYDGVITWTPPAIFKSSCP----MD
IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW-
-ENSEWEIVDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR---------------------
--------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPA
-THT-MPKWVKTIFLQ-------------AFPSILMMRKPLD--------------------------------------
------------KTKEAGGVKDPKS---HTKRPAKVK-------------------------------------------
-----------------------------------------------------------------------------FTH
RGESKLL------------------------------------------------------------------------K
ECHHCQKSS-------------------------------------------DIAPG-KRRSSQQPARWVAENSEHS---
-----------------------------------------------------------------SDVEDVIESVQFIAE
NMKSHNE-------------------------------------------------------------------------
----------------------------------------------------TNEVEDDWKYMAMVVDRVFLWVFIIVCV
FGT-VGLFLQPLLGNTGKS-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Canis_familiaris_CHRNA6
---------------------------------------------------------------------MLTSKGQGFLH
----FG---LCLCSCIFI--PCL------------------------------------------KGSAGCASEERLFHK
LFSH---YNQF-------------------------------------IRPVENVSDP----------------------
--VTVHFEVAITQLANVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWNPME-------------------
--YDG---IETLRVPADRIWKPDIVLYNN------AVGDFQVE-----GKTKALLKYDGMIIWTPPAIFKSSCP----MD
IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW-
-ENSEWEIVDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR---------------------
--------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLVGEYLLFTMIFVTLSIAVTVFVLNIHYRTPA
-THT-MPKWVKTVFLQ-------------LLPQILMMRRPLD--------------------------------------
------------KMRKTSSDKNSKG---ISSRPTKVN-------------------------------------------
-----------------------------------------------------------------------------FDN
YRETKLP------------------------------------------------------------------------K
ECCHCHKSS-------------------------------------------KLATS-KRRLSHQSLQWMTENSEHW---
-----------------------------------------------------------------PDVEDVINSVQFIAE
NMKNQNE-------------------------------------------------------------------------
----------------------------------------------------TKEVEDDWKYVAMVVDRVFLWVFIFVCV
FGT-AGLFLQPLLGNTGKS-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Myotis_lucifugus_CHRNA6
---------------------------------------------------------------------MLTSKGQGCLH
----CG---LCLWLYIFI--PFF------------------------------------------KDGAGCASEERLFHK
LFSH---YNQL-------------------------------------IRPVENVSEP----------------------
--VTVHFEVAITQLANVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWDPTE-------------------
--FDG---IETIRVPADKIWKPDIVLYNN------AVGDFQVK-----GKTKALLKYDGMITWTPPAIFKSSCP----MD
IT-------FFPFDHQNCSLKFGSWTYDKAE----IDLLIIGSK----------------------------VDMNDFW-
-ENSEWEIVDASGYKHDIKYNC--------------------C-EEIYTDITYSFYIRR---------------------
--------------------LPMFYTINLIIPCLFISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLVGEYLLFTMIFVTLSIAVTVFVLNIHYRTPT
-THT-MPDWVKMVFLQ-------------LLPQILMMKRPLD--------------------------------------
------------KTRKTSSDKNPKS---ISGRPTKVK-------------------------------------------
-----------------------------------------------------------------------------FDN
RREPKLL------------------------------------------------------------------------K
ECCHCHKSH-------------------------------------------QLATS-KRRLSHQPLQWMTGNTEHS---
-----------------------------------------------------------------PEVEDVINSVQFIAE
NMKNQNE-------------------------------------------------------------------------
----------------------------------------------------TKEVEDDWKYVAMVVDRVFLWIFIIVCV
FGT-AGLFLQPLLGNTGKS-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Ciona_savignyi_CHRNA6
--------------------------------------------------------------------------------
------------------------------------------------------------------------TEEKLFKR
LFDD---YNIW-------------------------------------IRPVANSNQS----------------------
--VLIAFELFVSQLVKVD--------------------------------------------------------------
-----EI-NQIMMTNLWLK-------------------------------------------------------------
----------------------------------------------QEWNDNK-LRWRPED-------------------
--YGG---VKYLRVPSEFIWKPDIVLYNT------AVGKFQVD-----QNTKALLRYNGDVSWMPPAIFKSSCS----ID
VT-------YFPFDTQNCTMKFGSWTYDKAR----VNLVIKGNE----------------------------ANRKEYW-
-ESGEWELLDVLGYRHERKYNC--------------------C-PEIYPDVTYSFHIRR---------------------
--------------------LPLFYMINLIIPCLLISFLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLVI----------------------TEIIPSTSLVIPLIGQYLLFTMIFVTLSIVITVFVLNVHFRSEN
-THT-MPPWVRRVFLE-------------CLPKASCFSHLFHS-------------------------------------
-------------SISSHNHNNVNKSLAHSATSLTHH-------------------------------------------
-----------------------------------------------------------------------------STS
PTHNTTTA------------------------------------------------------------------------
-ICHMNR-----------------------------------------------------------VSNAEKTEKTPDS-
--------------------------------------------------------------ALPKEVQRAIESVMYIAN
HLKVEDE-------------------------------------------------------------------------
----------------------------------------------------STEIENDWKYVGMVIDRIFLWIFIVVCV
LGT-TGIFLRPLLDDTHVG-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNB3
--------------------------------------------------------------------------------
-----MLPDFMLVLIVLGIPSS----------------------------------------ATTGFNSIAENEDALLRH
LF--QG-YQKW-------------------------------------VRPVLHSNDT----------------------
--IKVYFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWTDHK-LRWNPDD-------------------
--YGG---IHSIKVPSESLWLPDIVLFE------NADGRFEGS-----LMTKVIVKSNGTVVWTPPASYKSSCT----MD
VT-------FFPFDRQNCSMKFGSWTYDGTM----VDLILINEN----------------------------VDRKDFF-
-DNGEWEILNAKGMKGNRRDGV--------------------Y---SYPFITYSFVLRR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS
-TYHPMAPWVKRLFLQ-------------KLPKLLCMKDHVD--------------------------------------
---------------------RYSSPEKEESQPVVKG-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KVLEKKKQKQLSDG-----------
------------------------------------------------------------EKVLVAFLEKAADSIRYISR
HVKKEHFIS-----------------------------------------------------------------------
------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLIVSV
TGS-VLIFTPALKMWLHSYH------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Callithrix_jacchus_CHRNB3
--------------------------------------------------------------------------------
-----MLTDFMLVLIVLGIPSS----------------------------------------ATAGFSSIAENEDALLRH
LF--QG-YQKW-------------------------------------VRPVLHSNDT----------------------
--IKVYFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWTDHK-LRWNPDD-------------------
--YGG---IHSIKVPSESLWLPDIVLFE------NADGRFEGS-----LMTKVIVKSNGTVVWTPPASYKSSCT----MD
VT-------FFPFDRQNCSMKFGSWTYDGTM----VDLILINEN----------------------------VDRKEFF-
-DNGEWEILNAKGMKGNRRDGV--------------------Y---SYPFITYSFVLRR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSS
-TYQPMAPWVKRLFLQ-------------KLPKLLCMKDHVD--------------------------------------
---------------------RYSIPEKEESQPVVKS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KVLEKKKHKQLSDG-----------
------------------------------------------------------------EKVLVAFLEKAADSIRYISS
HVKKEHFIS-----------------------------------------------------------------------
------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLIVSV
TGS-VLIFTPALKMWLHSYH------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gallus_gallus_CHRNB3
--------------------------------------------------------------------------------
--------MLCLMLCVLCWSR----------------------------------------SDVAALGSVAENEDALLRH
LF--QG-YQKW-------------------------------------VRPVENSNDT----------------------
--IKVLFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWMDHK-LSWNPEE-------------------
--YGG---ITAIRVPSESLWLPDIVLFE------NADGRFEGS-----LMTKAIVKYNGVVTWMPPASYKSSCT----MD
VT-------FFPFDRQNCSMKFGSWTYDGSM----VDLILVDEN----------------------------VDRKDFF-
-DNGEWEILNAKGMKGNRKDGL--------------------Y---SYPFVTYSFVLRR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA
-TYHPMAPWVKRLFLQ-------------KLPRLLCMKGHVD--------------------------------------
---------------------RYSFSDTEEKETTLKS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KLPGKQKHKQAKDG-----------
------------------------------------------------------------EKVVIAFLEKAADSIRYISR
HVKKEHFIR-----------------------------------------------------------------------
------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLVVSV
TGS-VLIFTPALQMWLNSTL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Xenopus_tropicalis_CHRNB3
--------------------------------------------------------------------------------
---TMKMFIYACTNIIFIPSG------------------------------------------FAKFHPLAEIEDALLRK
LF--AG-YQKW-------------------------------------VRPVLNPNST----------------------
--IKVNFGLKISQLVDVD--------------------------------------------------------------
-----EK-KQLMTTNVWLR-------------------------------------------------------------
----------------------------------------------QEWMDMK-LRWNPKD-------------------
--YGG---ITYIRVPSESLWLPDIVLFE------NADGRFEGS-----LMTKAIIKYDGTVTWTPPASYKSSCT----MD
VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLILLDEN----------------------------VDRKDFF-
-DNGEWDILNATGLKGMRKDGL--------------------Y---SYPFITYSFVLRR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA
-TYHPMAPWVKRLFLE-------------KLPKLLCMKGHVD--------------------------------------
---------------------RFSFFDSESDVSSAKS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------KPSGKRKNIHASDG-----------
------------------------------------------------------------EKVLIAFLEKAADSIKYIST
HVKKEHFIR-----------------------------------------------------------------------
------------------------------------------------------QVVQDWKFVAQVLDRIFLWLFLSVSI
TGS-VLIFTPALQMWLNSHV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNB3_a
--------------------------------------------------------------------------------
-----MKLQISGILLVAAVAYA-------------------------------------TIEAPEEFVSLAEMEDTLLRN
LF--RG-YQKW-------------------------------------VRPVLHANDT----------------------
--ITVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLW-------------------------------------------------------------
----------------------------------------------EEWTDYK-LRWNPED-------------------
--YGG---ITSIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRFNGTIMWTPPASYKSACT----MD
VT-------FFPFDRQNCSMKFGSWTYDGTM----VDLTLVDAY----------------------------VDRKDFF-
-DNGEWEILNATGQRGSRRDGI--------------------Y---SYPYLTYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA
-TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD--------------------------------------
---------------------RYQYPDIELRSPELKR-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------G---MKKGQQKSAGG--GRAGVKE-
----------------------------------------------------------DENQAWIALLEKATHSVHYISR
HIRKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV
LGT-ILIFTPALQMFFSTS-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNB3_b
--------------------------------------------------------------------------------
-----MTLTVIGLFTLFTSIFA-------------------------------------TTP-AREFVSLAEREDALLRD
LF--QG-YQRW-------------------------------------VRPILHANHT----------------------
--VKVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLY-------------------------------------------------------------
----------------------------------------------EEWLDYK-LRWNPEN-------------------
--YGG---ITFIRVPSESIWLPDIVLYE------NADGRFEGS-----IMTKAIVRYNGLITWTPPASYKSACT----MD
VT-------FFPFDRQNCSMKFGSWTYDGNM----VELVLVNHQ----------------------------VDRSDFF-
-DNGEWEILSATGHKGSRRDGH--------------------Y---SYPYITYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKVSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA
-TYHPMSPWVRTLFLQ-------------RLPDLLCMRGNTD--------------------------------------
---------------------RYHYPQMEPQSPDLKP-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------R---SKKGPPGPEG-----------
-----------------------------------------------------------DGQALINMLEQATNSVRYISR
HIKKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV
LGT-ILIFTPAVKMFLSTPPPPSP--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNB3_a
--------------------------------------------------------------------------------
---------PPLLSVLLSVPIP-------------------------------------LAPAEEDFVSLAELEDSLLRN
LF--KG-YQKW-------------------------------------VRPVQHANDT----------------------
--ITVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLW-------------------------------------------------------------
----------------------------------------------QEWIDVK-LKWNPDD-------------------
--YGG---ITAIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSACN----MD
VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF-
-DNGEWEILNATGVKGSRRDEV--------------------Y---WYPFVTYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA
-TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD--------------------------------------
---------------------RYNFPDNEMRSPEPKP-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------R---RAIGRRGVQG--------KE-
----------------------------------------------------------DENQAWLAMLEKATNSVRYISQ
HIRKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI
LGT-VLIFTPALKMYLHKMFH-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNB3_b
--------------------------------------------------------------------------------
---------HLPDQLVCAKTSL-------------------------------------SAPAQSEFVSLAEMEDALLRN
LF--QG-YQRW-------------------------------------VRPIQHANDT----------------------
--IKVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLC-------------------------------------------------------------
----------------------------------------------QEWIDFK-LRWNPDK-------------------
--YGG---ITSIRVPSENLWLPDIVLYE------NADGRFEGS-----LMTKAIVRYNGAITWTPPASYKSACT----MD
VT-------FFPFDRQNCTMKFGSWTYDGTM----VDLILIDKQ----------------------------VDRKDFF-
-DNGEWEILSATGAKGNRKDGL--------------------Y---SYPFITYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA
-TYHPMSPWVRTLFLQ-------------KLPSLLCMRGHTD--------------------------------------
---------------------RYHYPELGPESPEPKP-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------RSGGRRGGQRISSGGTYGQASSEG-
----------------------------------------------------------KDDEDWATMLDKAIFSVRYISR
HIRKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV
LGT-ILIFTPALQKFMQVLP------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNB3_a
--------------------------------------------------------------------------------
--------LLVASVCFFPVFHM-------------------------------------FAPAQSEFVSLAEMEDALLRN
LF--QG-YQRW-------------------------------------VRPIQHANDT----------------------
--IKVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLC-------------------------------------------------------------
----------------------------------------------QEWIDYK-LRWNPDK-------------------
--YGG---ITSIRVPSENLWLPDIVLYE------NADGRFEGS-----LMTKAIVRYNGAITWTPPASYKSACT----MD
VT-------FFPFDRQNCTMKFGSWTYDGTM----VDLILIDKQ----------------------------VDRKDFF-
-DNGEWEILSATGAKGNRKDGL--------------------Y---SYPFITYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA
-TYHPMSPWVRTLFLQ-------------KLPRLLCMRGHTD--------------------------------------
---------------------RYHYPELGPESPEPRV-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------RAGGRRGGQRVGSG-SHGQTPPEG-
----------------------------------------------------------KDDEEWASMLDKAIYSVRYISR
HIRKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSV
LGT-ILIFTPALQKFMKVLPQSSS--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNB3_b
--------------------------------------------------------------------------------
---------------------------------------------------------------QEDFVSLAELEDSLLRN
LF--RG-YQKW-------------------------------------VRPVQHANDT----------------------
--ITVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLW-------------------------------------------------------------
----------------------------------------------QEWVDVK-LKWNPDD-------------------
--YGG---ITAIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSACT----MD
VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF-
-DNGEWEILNATGVKGSRRDGI--------------------Y---WYPFVTYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA
-TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD--------------------------------------
---------------------RYHFPDMEMHSPELKP-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------R---RAVGRRGVQGQQKGPLAGKE-
----------------------------------------------------------DENQAWLAMLEKATNSVRYISQ
HIRKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI
LGT-VLIFTPALQMYLSTP-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNB3_a
--------------------------------------------------------------------------------
---------------------------------------------------------------QDDVVSLAEMEDSLLRN
LF--RG-YQKW-------------------------------------VRPVLHSNDT----------------------
--ITVCFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLW-------------------------------------------------------------
----------------------------------------------QEWVDLK-LKWNPDD-------------------
--YGG---ITSIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSACT----MD
VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF-
-DNGEWEILNATGQRGSRRDEV--------------------Y---WYPFVTYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYL--------------------HHRSSS
-TYHPMAPWVKSLFLQ-------------RLPRLLCMRGHTD--------------------------------------
---------------------RYHFEDMEMHSPEVKT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------R---RGVGRRGAPGQ-RGPVSGKE-
----------------------------------------------------------EENRAWLAMLEKATSSVRYISR
HIKKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRILLWAFLTVSI
LGT-VLIFTPALQMYFSTP-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNB3_b
--------------------------------------------------------------------------------
-----MKWTVLFLLLVCPLSLA-------------------------------------EIHAPSEFVSLAEMEDALMRN
LF--QG-YQRW-------------------------------------VRPIQHANDT----------------------
--VRVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLW-------------------------------------------------------------
----------------------------------------------QEWIDYK-LRWNPDK-------------------
--YGG---ITSIRVPSEIIWLPDIVLYE------NADGRFEGS-----LMTKAIVKFNGVITWTPPASYKSACT----MD
VT-------FFPFDRQNCTMKFGSWTYDGHM----VDLVLIDNQ----------------------------VDRRDFF-
-DNGEWEILSATGARGTRKDDM--------------------Y---TYPFLTYSFILKR---------------------
--------------------LPLFYTLFLIFPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLL---------------------RSSA
-TYHPMSPWVRNLFLQ-------------KLPRFLCMRGHTD--------------------------------------
---------------------LYHYPELAPESPEMKP-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------RSGGRKGGQRANSG-ARGQTASEG-
----------------------------------------------------------KEDEAWATMLDKAVYSVRYISR
HIRKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI
LGT-VLIFTPALYSFFKIP-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNB3_a
--------------------------------------------------------------------------------
--------------------FP-------------------------------------LLPVQENVLSLAELEDSLLRN
LF--KG-YQKW-------------------------------------VRPVQHANDT----------------------
--ITVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLW-------------------------------------------------------------
----------------------------------------------QEWIDVK-LKWNPDD-------------------
--YGG---ITSIRVPSETIWLPDIVLYE------NADGRFEGS-----LMTKAIVRWDGTITWTPPASYKSSCT----MD
VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLVDHY----------------------------VDRKDFF-
-DNGEWEILNATGQRGSRRDEM--------------------Y---WYPFLTYSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSA
-TYHPMAPWVKSLFLQ-------------KLPRLLCMRGHTD--------------------------------------
---------------------RYHFPDIEMRSPELKT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------R---RGAGRRAVPG-------GME-
----------------------------------------------------------DDSQAWLAMLEKATNSVHYISR
HIRKEHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWAFLTVSI
LGT-VLIFTPALQSYLSTP-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNB3_b
--------------------------------------------------------------------------------
-----LTVFLLLLLSACPQLFA-------------------------------------AITAPKRFVSLAEMEDDLLKN
LF--QG-YQRW-------------------------------------VRPIQRPNDT----------------------
--VRVRFGLKISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLR-------------------------------------------------------------
----------------------------------------------QEWIDYK-LRWNPDK-------------------
--YGG---ITSIRVPSENIWLPDIVLYE------NADGKFEGS-----LMTKAIVKFNGAVTWMPPASYKSACT----MD
VT-------FFPFDRQNCSMKFGSWTYDGNM----VDLVLMDSQ----------------------------VDRKDFF-
-DNGEWEILSATGAKGNRKDGL--------------------Y---FYPFITCSFILKR---------------------
--------------------LPLFYTLFLIIPCLGLSFLTVLVFYLPSDEG-------------------EKLSLS----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSA
-TYHPMSPWVRSLFLQ-------------KLPRLLCMRGHAD--------------------------------------
---------------------RYHYPELAPESPALKS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------RSGGRRGIQRMSSG--GQQSTYDG-
----------------------------------------------------------KEEEAYSTMLEKAIYSVRYISR
HIRKDHFIR-----------------------------------------------------------------------
------------------------------------------------------EVVQDWKFVAQVLDRIFLWIFLSVSV
LGT-ILIFTPALQMFMKIPPPAPSE-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNA4
----------------------------------------------------------------------------MELG
GPGAPRL--LPPLLLLLGTGLLR---------------------------------------ASSHVETRAHAEERLLKK
LFSG---YNKW-------------------------------------SRPVANISDV----------------------
--VLVRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWVK-------------------------------------------------------------
----------------------------------------------QEWHDYK-LRWDPAD-------------------
--YEN---VTSIRIPSELIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFHDGRVQWTPPAIYKSSCS----ID
VT-------FFPFDQQNCTMKFGSWTYDKAK----IDLVNMHSR----------------------------VDQLDFW-
-ESGEWVIVDAVGTYNTRKYEC--------------------C-AEIYPDITYAFVIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR
-THT-MPTWVRRVFLD-------------IVPRLLLMKRPS---------------------------------------
-------------VVKDNCRRLIESMHKMASAPRF---------------WPEPE--GEPPATSGTQSLHP-------PS
PSFCVPLDVPAEPGP--------------------SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPP-HGTQAPGLAKAR
SLSVQHMSS---------------------------------------------PGEAVEGGVRCR-------------S
RSIQYCVPRDDAAPEADGQA------AGALAS----RNTHSAELP----PPDQPSPCKCTCKKEPSSVSPSATVKTRS--
------------------------------------------------------TKAPPPHLPLSPALTRAVEGVQYIAD
HLKAEDT-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRNA4
----------------------------------------------------------------------------MEIG
GSGAPPPLLLLPLLLLLGTGLLP---------------------------------------ASSHIETRAHAEERLLKR
LFSG---YNKW-------------------------------------SRPVANISDV----------------------
--VLVRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWVK-------------------------------------------------------------
----------------------------------------------QEWHDYK-LRWDPGD-------------------
--YEN---VTSIRIPSELIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFYDGRVQWTPPAIYKSSCS----ID
VT-------FFPFDQQNCTMKFGSWTYDKAK----IDLVSMHSR----------------------------VDQLDFW-
-ESGEWVIVDAVGTYNTRKYEC--------------------C-AEIYPDITYAFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECG-------------------EKVTLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPR
-THT-MPAWVRRVFLD-------------IVPRLLFMKRPS---------------------------------------
-------------VVKDNCRRLIESMHKMANAPRF---------------WPEPE--SEPGILGDICNQGLS------PA
PTFCNRMDTAVETQP--------------------TCRSPSHKVPDLKTSEVEKASPCPSPGSCHPP-NSSGAPVLIKAR
SLSVQHVPS---------------------------------------------SQEAAEGSIRCR-------------S
RSIQYCVSQDGAASLTESKP------TGSPAS----LKTRPSQLP----VSDQTSPCKCTC-KEPSPVSPITVLKAGG--
------------------------------------------------------TKAPPQHLPLSPALTRAVEGVQYIAD
HLKAEDT-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFIIVCL
LGT-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Monodelphis_domestica_CHRNA4
----------------------------------------------------------------------------MRLQ
GPQGSALLLLLLRGLLILGVLLP---------------------------------------ASGHVETRAHAEERLLKK
LFSG---YNKW-------------------------------------SRPVANISDV----------------------
--VLVRFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNMWVK-------------------------------------------------------------
----------------------------------------------QEWQDYK-LRWDPMD-------------------
--YEN---VTSIRIPSELIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFYDGRIKWTPPAIYKSSCS----ID
VT-------FFPFDQQNCTMKFGSWTYDKAK----IDLVSMHSH----------------------------VDQLDYW-
-ESGEWVIISAVGNYNIKKYEC--------------------C-TETYSDITYSFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPR
-THT-MPAWVRRVFLD-------------IIPRLLFMKRPG---------------------------------------
-------------VVKDNCRKLVESMHKLAGGPRF---------------WPQP----EPNFVTSPSTSPQTPE--RSPS
ASFCVHLEDPVKPQA--------------------VCKSPSGQYTVLQRPEPGKGS-PCSPPTPHPPLNNSHPSGFSKVR
SLSVQQMYS---------------------------------------------SNKVEEGSIRCR-------------S
RSIQYCSLQEDSSQANNGQS------TSSPAS----LRSQKDEVQ----PQEKPSPCKCKCKKVKATPVPDPVTKPRS--
-------------------------------------------------------TKEQHALPMSPALKLAVEGVQYIAD
HLKAEDT-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVIVCL
LGT-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNA4_a
-------------------------------------------------------------------------------M
RAAWRVFFLLCVHLQLAY--------------------------------------------VFSMSPAHAHAEERLLQS
LFIN---YNKL-------------------------------------SRPVANISDV----------------------
--VLVHFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWVK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWNPEE-------------------
--YEN---VTSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAQVFYNGRIKWKPPAIYKSSCS----ID
VT-------FFPFDQQNCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW-
-ESGEWVIINAVGTYNIKKYEC--------------------C-TEIYPDITYSFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSECA-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSSR
-THS-MPHWVRQLFLH-------------LVPRYLFMKRPP-A-------------------------------------
-------------SGKRNCGKLIEMMHKQANSQSMFLRNN----------ILDISPQSPIPHLGPTSAAQQDQVQQDSTS
PKPLFFCSSPSSQYSI--------------LQEENSQTPQTPVLSYTCAYTNSIFASSTTSFPDTLLGTLLHTIPQDGAK
STECDFQGHS-------------------------------------------AESVFMEAKESVLG------------A
GSCQHCLTSEGTSLQKLDLD----------------------------------EAGRCTRHNMPSAQIFSPSSDGST-D
------------------------------------------------------LNAAEPVSNLSQSLLKALEGVQYIAD
HLRAEDS-------------------------------------------------------------------------
----------------------------------------------------DFSVREDWKYVAMVIDRIFLWMFVLVCI
LGT-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNA4_a
-------------------------------------------------------------------------TEWISSG
LDPPALPHHLHFIWITSSSLAG-----------------------------------------FSQVAPRAHAEERLLQD
LFAH---YNKL-------------------------------------SRPVENTTDT----------------------
--VLVHFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWVK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWNPEE-------------------
--YEN---VTSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAQLFYDGRIKWMPPAIYKSSCS----ID
VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW-
-ESGEWVIVNAVGKYNTKKYEC--------------------C-TEIYSDITYYFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIIITVFVLNVHHRSPQ
-THG-MPHWVRRVFLD-------------FVPKVLFMKRPP-G-------------------------------------
-------------TAKQHCKKLIEMMHRPATVSGP--------------------------------------------S
PSPPSSPLANCNKDNQSLNANTFCQSISGRYSLLSEKQLLHGHKSAASSSSQLSLPPTLPLGLLHKRTNKESNTMASIGR
SLSVEHMFDGQ-------------------------------------------KEAPCRGRYRRR-------------S
RSFQYCCLHDEGAGLTRATW----------------------------------GQKKHPSADHLVEIIMAESTKDTS--
------------------------------------------------------SLQDFEVSTISPAMQRAIEGVQYIAD
HLRAEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVLVCI
LGS-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNA4_a
--------------------------------------------------------------------------------
----------------------------------------------------------------IQVAPRAR-RRRLLRD
LFAH---YNRL-------------------------------------SRPVENTTDT----------------------
--VLVHFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWVK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWNPEE-------------------
--YEN---VTSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAQLFYDGRIKWMPPAIYKSSCS----ID
VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLVSMASD----------------------------VDQMDYW-
-ESGEWVIVNAVGKYNIKKYEC--------------------C-TEIYSDITYYFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIIITVFVLNVHHRSPQ
-THG-MPHWVRRVFLD-------------FVPKVLFMKRPP-G-------------------------------------
-------------TAKQHCKKLIEMMHRPATVSEVENSSSFW-------TGLETELRQMGQVQKTIPKALTDSPSIRISS
PSPPSSPLVNCNKGNQSLNANTFCQSISGQYSLLSEKKLLHGHKTAAFSSSQLSLPPTLPLGRLHNHTDEESNTIALNGR
SLSVEHMFDDR-------------------------------------------KEASRPGGYRRR-------------S
RSFQYCCLHDEGVGLTRTTG----------------------------------EMKKQPSADHLGETIMAESTKDTS--
------------------------------------------------------SLQNIELSTISPAMQRAIEGVQYIAD
HLRAEDS-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFILVCI
LGS-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNA4_a
--------------------------------------------------------------------------------
-------LPPLLSYLVANLCLS-----------------------------------------RTHVRPRAHAEERLLQD
LFAR---YNKL-------------------------------------SRPVENTSDT----------------------
--VLVHFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWVK-------------------------------------------------------------
----------------------------------------------QEWSDYK-LRWKPED-------------------
--YEN---VSSIRIPSEIIWRPDIVLYNN------ADGDFAVT-----HLTKAHLFHDGRIKWMPPAIYKSSCS----ID
VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW-
-ESGEWVIINAVGKYNTKKYEC--------------------C-AEIYSDITYYFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIVITVFVLNVHHRSPQ
-THS-MPHWVRRVFLD-------------MVPRVLFMKRPP-G-------------------------------------
-------------TAKQHCKKLIEMMHRPTAISATGNSLAYW-------TGLETGLRQMCQAENALPKTPCDSPSIHVCS
PAPPSSPPEDCEEDDRLLKAN-------------------------------LSLPPALPLGPLRSFSQEEPNAMAPNGR
SLSAEQMFDQQ-------------------------------------------GDLSQRAGHRCR-------------S
RSFQYCCLHGEGPGLMAVAG----------------------------------WVKKQAPTNHPAGRVTGESTKDAS--
------------------------------------------------------TQQDIVIPTISPAVQRAIEGVQYVAD
HLRAEDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVLVCI
LGS-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNA4_a
--------------------------------------------------------------------------------
---------------------------------------------------------------SSQIEPRAHAEERLLQN
LFAR---YNKL-------------------------------------SRPVQNTSDT----------------------
--VLVHFGLSIAQLIDVD--------------------------------------------------------------
-----EK-NQMMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWNDYK-LRWNPED-------------------
--YEN---VTSIRIPSEIIWRPDIVLYNNH----SADGDFAVT-----HLTKAHLFYDGQIKWMPPAIYKSSCS----ID
VT-------FFPFDQQSCKMKFGSWTYDRAK----IDLISMASD----------------------------VDQMDYW-
-ESGEWVIVNAVGKYNTKKYEC--------------------C-AEIYADITYYFIIRR---------------------
--------------------LPLFYTINLIIPCLLISCLTVLVFYLPSQCG-------------------EKITLC----
ISVLLSLTVFLLLI----------------------TEIIPSTSLVIPLIGEYLLFTMVFVTLSIIITIFVLNVHHRSPQ
-THG-MPHWVRRVFLD-------------LVPRVLFMKRPP-G-------------------------------------
-------------TAKQHCKRLIEMMHCPTTISATGNSQSFW-------TGLDSELRQMTQVHNSLPK--VDSPRILVCS
PSPSSSPVDDCSDEDHPLKADIFCQTPSGQYSPLLEHQALCRHISTTHSAPQLSMP----LGPFPCLSREHPSPLARNGR
SLSVEQMCGKQ-------------------------------------------GQPPQRSAHRCR-------------S
QSFQYCCLHNDG--AAGFTG----------------------------------QTNKTP--EQLTETLAAEFAKDAS--
------------------------------------------------------TQLDNMAPIVSPAMQRAIEGVQYIAD
HLRAGDA-------------------------------------------------------------------------
----------------------------------------------------DFSVKEDWKYVAMVIDRIFLWMFVLVCI
LGS-VGLFLPPWLAGMI---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNA3
------------------------------------------------------------------------------MG
SGPLSLPLALSPPRLLLLLLLS-----------------------------------------LLPVARASEAEHRLFER
LFED---YNEI-------------------------------------IRPVANVSDP----------------------
--VIIHFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLK-------------------------------------------------------------
----------------------------------------------QIWNDYK-LKWNPSD-------------------
--YGG---AEFMRVPAQKIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGEVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGSS----------------------------MNLKDYW-
-ESGEWAIIKAPGYKHDIKYNC--------------------C-EEIYPDITYSLYIRR---------------------
--------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT
-THT-MPSWVKTVFLN-------------LLPRVMFMTRPTSN-EGNAQKP-----------------------------
------------RPLYGAELSNLNCFSRAESKGCKEG-------------------------------------------
------------------------------------------------------------------------------YP
CQDGMCG-------------------------------------------------------------------------
-YCHHRRIK--------------------------------------------ISNFSANLTRSSSSESVDAVLSLS---
--------------------------------------------------------------ALSPEIKEAIQSVKYIAE
NMKAQNE-------------------------------------------------------------------------
----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFTLVCI
LGT-AGLFLQPLMAREDA--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryctolagus_cuniculus_CHRNA3
--------------------------------------------------------------------------------
-----MGAPPPPPPSPVLLLLLLL---------------------------------------LPPVVSASEAEHRLFER
LFED---YNEI-------------------------------------IRPVANVSDP----------------------
--VIIQFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLK-------------------------------------------------------------
----------------------------------------------QIWNDYK-LKWNPSD-------------------
--YNG---AEFMRVPAQKIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGEVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGSS----------------------------MNLRDYW-
-ESGEWAIIKAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR---------------------
--------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPT
-THT-MPAWVKTVFLN-------------FLPRVMFMTRPASD-GDSAQMP-----------------------------
------------QLLAGAELSNLGCFGRTEPKACKEG-------------------------------------------
------------------------------------------------------------------------------CP
CQDGACG-------------------------------------------------------------------------
-YRHHRRVK--------------------------------------------MSNFGANLTRSSSLESVDAVLSLS---
--------------------------------------------------------------ALSPEIREAIRSVQYIAE
NMKAQNE-------------------------------------------------------------------------
----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFILVCI
LGT-AGLFLQPLMARDDA--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Taeniopygia_guttata_CHRNA3
--------------------------------------------------------------------------------
------------------------------------------------------------------GCGGSEAEHRLYAA
LFKS---YNQF-------------------------------------VRPVKNVSDP----------------------
--VIIQFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLK-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWNPAD-------------------
--YGG---AEFIRVPSGQIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGDVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGST----------------------------MNLKDYW-
-ESGEWAIIKAPGYKHDIKYNC--------------------C-EEIYPDITYSLYIRR---------------------
--------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK
-THT-MPVWVKTIFLN-------------LLPRIMFMTRPASD-EENNQKP-----------------------------
------------KPLFTSEFSNLNCINGSETKSCKDG-------------------------------------------
------------------------------------------------------------------------------FA
CQDMACS-------------------------------------------------------------------------
-CCQYQR---------------------------------------------------------TNSESVDPMLSFS---
--------------------------------------------------------------VLSPEMRDAIESVKYIAE
NMKMQNE-------------------------------------------------------------------------
----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFILVCI
LGT-AGLFLQPLM-------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Pelodiscus_sinensis_CHRNA3
--------------------------------------------------------------------------------
QTSAPLSLPSTAFSKEVSLLILPA---------------------------------------TLSVSNCSEAEHRLFAS
LFAN---YSQF-------------------------------------IRPVENVSDP----------------------
--AIIQFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLK-------------------------------------------------------------
----------------------------------------------HIWNDYK-LKWNPEE-------------------
--YGG---AEFIRVPSDSIWKPDIVLYNN------AVGDFQVD-----DKTKALLKYTGEVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWSYDKAK----IDLVLIGST----------------------------MNLKDYW-
-ESGEWAIIKAPGYKHDIKYNC--------------------C-EELYPDITYSLYIRR---------------------
--------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK
-THT-MPEWVKTIFLN-------------LLPKIMFMTRPASD-EETTQKL-----------------------------
------------KPLYSVELSDLNCFSSSETKCCKEG-------------------------------------------
------------------------------------------------------------------------------FI
CQDTACS-------------------------------------------------------------------------
-CCRYQRIK--------------------------------------------FSDFSGNLTRSSSYESVDALLSLS---
--------------------------------------------------------------VLSPEIRDAIESVKYIAE
NMKMQNE-------------------------------------------------------------------------
----------------------------------------------------AKEIQDDWKYVAMVIDRIFLWVFILVCI
LGT-AGLFLQPLMTRDEI--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNA3_a
--------------------------------------------------------------------------------
--------MQLIHFIIASTIQLCV---------------------------------------SVSGVCCSEAEHRLFSV
IFSS---YNQY-------------------------------------IRPVENVSDP----------------------
--VVVQFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWDPKD-------------------
--FGG---VEFIRVPSNKIWKPDIVLYNN------AVGDFQVD-----DKTKALLRFNGDVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------INLKDFW-
-ESGEWTIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR---------------------
--------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK
-THT-MPCWVRRVFLS-------------LLPRVMFMTRPEKDQEVPAKH---------KQTSVCRG-------------
--------------------PQLLLCPTELNEASRTA-------------------------------------------
------------------------------------------------------------------------------FL
CREHHCW-------------------------------------------------------------------------
-KKHISNMT-------------------------------------------SEGAEDGGSPCSSSESLDG-FLCMS---
--------------------------------------------------------------AVSPQVREAIESVKYIAE
NMRLQNE-------------------------------------------------------------------------
----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI
LGT-AGLFLQPLLLGEDM--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNA3_a
--------------------------------------------------------------------------------
---------------------LLF---------------------------------------LLPGGCCSEAEHKLFSV
IFSN---YNQY-------------------------------------IRPVENVTDP----------------------
--VIVQFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRW-PKE-------------------
--YGG---VEYIRVPSSRIWKPDIVLYNN------AVGDFQVD-----DKTKALLRYNGDVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------MNLKDFW-
-ETGDWLIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR---------------------
--------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK
-THT-MPCWVRAVFLE-------------LLPRVMFMTRPERHAFQVLRRP-----------------------------
--------------LSNTELSNLNNLSGDPSKGSTS--------------------------------------------
-------------------------------------------------------------------------------L
CCEGRCN-------------------------------------------------------------------------
-CCWYQRSR------------------------------------------GSVAKVSGGSQRSSSESLNGGLMPLL---
--------------------------------------------------------------PLSPEVREAIESVRYIAE
NMRLQNE-------------------------------------------------------------------------
----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI
LGT-AGLFLQPLLLAEDI--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNA3_a
--------------------------------------------------------------------------------
---------------------LLF---------------------------------------RLPGGSCSEAEHKLFSV
IFSN---YNQY-------------------------------------IRPVENVTDP----------------------
--VIVQFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWNPKE-------------------
--YGG---VEYIRVPSSRIWKPDIVLYNN------AVGDFQVD-----DKTKALLRYNGDVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------MNLKDFW-
-ETGDWLIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR---------------------
--------------------LPLFYTINLIIPCLLISFLTVLVFYLPSDCG-------------------EKVTLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK
-THT-MPRWVRAVFLE-------------LLPRVMFMIRPEREPEQGRGAG-NAQDMHPRSCSVHSS-------------
------------------ELSNLNNLSGDLTKGSTS--------------------------------------------
-------------------------------------------------------------------------------L
CCEGRCN-------------------------------------------------------------------------
-CCWYQRS-----------------------------------------------KVSGGSQCSSSDSLNGGLMPQL---
--------------------------------------------------------------PLSPEVREAIESVRYIAE
NMRLQNE-------------------------------------------------------------------------
----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI
LGT-AGLFLQPLLLAEDI--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNA3_a
--------------------------------------------------------------------------------
------------------------------------------------------------------------AEHKLFSV
IFSS---YNQY-------------------------------------IRPVENVTDP----------------------
--VVVQFEVSMSQLVKVD--------------------------------------------------------------
-----EV-NQIMETNLWLR-------------------------------------------------------------
----------------------------------------------HIWNDYK-LRWNPKD-------------------
--FGG---VDFIRVPSNRIWKPDIVLYNN------AVGDFQVD-----DKTKALLRFNGDVTWIPPAIFKSSCK----ID
VT-------YFPFDYQNCTMKFGSWTYDKAK----IDLVLIGST----------------------------INLKDFW-
-ESGEWTIIDAPGYKHDIKYNC--------------------C-EEIYTDITYSLYIRR---------------------
--------------------LPLFYTINMIIPCLLISFLTVLVFYLPSDCG-------------------EKITLC----
ISVLLSLTVFLLVI----------------------TETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPK
-THT-MPCWVRTVFLG-------------LLPRVMFMTRPETDAERVLAAAGDVQTTHLRPCAIHPSGALQKQHKPQAPP
PPSVVSSLTNRQRLFNNTELSDLNNLSGDPAKGAGSA-------------------------------------------
------------------------------------------------------------------------------LL
CCKGHCN-------------------------------------------------------------------------
-CCWRQRSSKLPADSGGGSGGLG---------------------SMG--ALSGGSAVGGGSHCSSSESVAGGTMSML---
--------------------------------------------------------------PLSPEVQEAIESVKYIAE
NMRLQNE-------------------------------------------------------------------------
----------------------------------------------------AKEVQDDWKYVAMVIDRIFLWVFVLVCI
LGT-AGLFLQPLLLWDDI--------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNB4
--------------------------------------------------------------------------------
--------------------------MRRAPSLVLFFL---------------------VALCGRGNCRVANAEEKLMDD
LLNKTR-YNNL-------------------------------------IRPATSSSQL----------------------
--ISIKLQLSLAQLISV-N-------------------------------------------------------------
-----ER-EQIMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWTDYR-LTWNSSR-------------------
--YEG---VNILRIPAKRIWLPDIVLYNN------ADGTYEVS-----VYTNLIVRSNGSVLWLPPAIYKSACK----IE
VK-------YFPFDQQNCTLKFRSWTYDHTE----IDMVLMTPT----------------------------ASMDDFT-
-PSGEWDIVALPGRRTVNPQ------------------------DPSYVDVTYDFIIKR---------------------
--------------------KPLFYTINLIIPCVLTTLLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTFFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPS
-THT-MAPWVKRCFLH-------------KLPTFLFMKRPG---------------------------------------
-------------PDSSPARAFPPSKSCVTKPEATATS------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------TSPSNFYGNSMYFVNPASAAS---
------KSPAGSTP-VA---------------------------------IPRDFWLR-SSGRFRQDVQEALEGVSFIAQ
HMKND-DEDQSVV-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVVDRLFLWVFMFVCV
LGT-VGLFLPP--LFQTHAASEGPYAAQRD--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNB4_b
--------------------------------------------------------------------------------
------------------------------------------------------------------XGVCADSEERLMNW
LLGKHR-YNKL-------------------------------------IRPALNRTER----------------------
--VTVLLQVSLAQLISV-N-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QNWNDYR-LSWDPAE-------------------
--YEG---IDKLRIPSRHIWLPDIVLYNN------ADGTYEVT-----VFTNAIVLFNGSIAWLPPAIYKSACK----IE
VK-------HFPFDQQNCTLKFRSWTYDHTE----IDLLLKSDA----------------------------ASMDDFT-
-PSGEWDILALPGRRTVSPL------------------------DATYVDLTYDFIIKR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS
-THS-MPAWVKIVFLV-------------RLPALLFMQR-----------------------------------------
-------------PRGHSARQRLRQNRRLLGLADTPGRSVMC--------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------SSASALLAASSASALSSPGLLYNKGHFGSRR-
-----AEGLNNGHG------------------------------------SAQDLKGNRLYCEWGSEIQEAVDGVRYVAD
HMMGN-DDDQSVI-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVVDRLFLWIFVIVCV
VGT-LGLFLQP--LFQNQTLAIQQPNTEPARRDGM---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNB4_a
--------------------------------------------------------------------------------
-----------------------------LWGRLMTVLS----------------LNSLIYHGVPSGCRCADSEERLMNW
LLGKNR-YNPL-------------------------------------IRPASNRTER----------------------
--VPVKLQVSLAQLISV-N-------------------------------------------------------------
-----ER-EQIMTTNLWLM-------------------------------------------------------------
----------------------------------------------QHWVDYR-LSWDPAK-------------------
--YEG---INKLRIPSRLIWLPDIVLYNN------ADGTYEVT-----VFTNAIVLFNGSINWLPPAIYKSACK----IE
VK-------HFPFDQQNCTLKFRSWTYDRTE----IDLVLKTDA----------------------------ASMDDFT-
-PSGEWDILALPGRRTVNPL------------------------DPTYVDLTYDFIIKR---------------------
--------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS
-THT-MPSWVKLIFLV-------------KLPSLLFIRR-----------------------------------------
-------------PQNNSARQRLQSQRCQRAKRDILG-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------LGCQ--PKSSITMLSSALLSPGSVFSTPG-
-----QKNVAPSLS----------------------------------LNITQNLQQS-SGADWAADVQEALSGVRFVAE
HMMED-DDDQSVI-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVVDRMFLWIFVIVCV
VGT-LGLFLQP--VFQNPITPIQQPSSDM---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNB4_a
--------------------------------------------------------------------------------
-------------------------------FGCEYTTC----------------AFKLWNINVSPGSRCAESEERLMNW
LLGKDR-YNLL-------------------------------------IRPAVNRTER----------------------
--VPVKLQVSLAQLISV-N-------------------------------------------------------------
-----ER-EQIMTTNVWLT-------------------------------------------------------------
----------------------------------------------QHWVDYR-LSWDPAK-------------------
--YEG---IDKLRIPSRHIWLPDIVLYNN------ADGTYEVT-----VFTNAIVIFNGSINWLPPAIYKSACK----IE
VK-------HFPFDQQNCTLKFRSWTYDHTE----IDLILKSEV----------------------------ASMDDFT-
-PSGEWDILALPGRRTVNPL------------------------DPTYVDLTYDFIIKR---------------------
--------------------KPLFYTINLIIPCVLITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS
-THT-MPSWVKLIFLV-------------KLPALLFMRR-----------------------------------------
-------------PQNNSASQRLRRQRCLRARKSIGS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------SGYPDAAKTGFILSPSALKG------DLR-
-----STDYIPSGQ---------------------------------------DLKQS-TSSDWAADVQEAVNGVRFVAE
HMMGD-DDDQSVI-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVVDRMFLWIFVIVCV
VGT-LGLFLQP--VFQTQIVPNQQ--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNB4_a
--------------------------------------------------------------------------------
-------------------------------------------------------------------CKSADSEERLMNM
LLGKHR-YNPL-------------------------------------IRPAINRTER----------------------
--VEVKLQVSLAQLISV-N-------------------------------------------------------------
-----ER-EQIMTTNVWIT-------------------------------------------------------------
----------------------------------------------QHWVDYR-LSWDPAK-------------------
--YEG---IQKLRIPSRHVWLPDIVLYNN------ADGIYEVT-----VFTNVIVLFNGSVNWLPPAIYKSACK----IE
VK-------HFPFDLQNCTLKFRSWTYDHTE----IDLILKSEA----------------------------ASMDDFT-
-PSGEWDIIALPGRRTVNPT------------------------DPTYVDLTYDFIIKR---------------------
--------------------KPLFYTINLIIPCILITSLAILVFYLPSDCG-------------------EKMTLC----
ISVLLALTVFLLLI----------------------SKIVPPTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPS
-THT-MPSWVKLIFLK-------------KLPALLFMKR-----------------------------------------
-------------PNNFSGCQRLRQQRCLRARRSILG-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------LDYPNASKACFTLSSSALLPSDSAFSTPR-
-----HKNLAPTMGYGLSRRKGDLSSSD---------------YPHISLTPTQDYQQK-CKSDWTADVKEAVKGVRFVAE
HMMAD-DDDQSVI-------------------------------------------------------------------
---------------------------------------------------------EDWKYVAMVVDRMFLWIFVIVCV
VGT-LGLFLQP--LFQSQMITSQQPSSDKPRI------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Trichoplax_adhaerens_CHRNB4
--------MVATAQKNCYIYAILFASILSHSICNAQKTLFSVLEQQQTQNAVMISTNGDAIIAGLLPAHYNYEDGKHKCS
ELDTYGIHLMMAMIFAINDINEQSNLLPDVKLGYDIRDTCHN-------------SLRVSKEIMALLMQYLPFKEGKYDG
FFCEKIKYDEANEETVRTYGPIIGVIGTTMSDSTIATANTIGNFGVIEITPSALAVTQSDNQPPNLYSTQPSFYDHLVVI
SKIIIALDMTRICLITIEPPETSYRMDLLRTILQDAKICIAQEFSITGDRMSLAMARVIQNLKANNKLQVVVLLGPYEKG
VRFMKEAERQNLTGRTWIG-------------------------------------------------------------
---------------------------------------------AGEWVKSPAIYSIRKEVMGGLLAVSTQTFRSVLIT
KHLENYVTSDTRNVHLDQLWKKLYNCTPNEENCEVRLGSYEIIDEKKSSCEYYQSELNEDIIYVIDAVYAIAHALHQTLN
CTIEFCN-SVETFNHTIFNYHLQRVEFSNHAN-QPVEFQQNKGVRHILIQN-------------------LHHDDNCSHF
VEVARWNPFESEMIMDTNKIRWRNGESTTIPTEVYETACTPGDRKHSFDQESCYYVCLKCGPSLVSNGTTSQCFKCSPGF
KPTNNRSACQEIPPTKLDWRNPVNLTILIFTLLSMLTLLFIVIIFFKYSNTP-----------------IVKASNKI---
MSHIQLLSVALLFILGG-------------SYQFAVTTSLCWFQFAICSVSFPLCEACLLAKTKHVANVFTLSSRIQKVD
KSSRLQSRWCKSLIPILFVLS------ITAIPIIIWLIFTIID-------------------------------------
-------------PPNAIPDYRYENEVHILCSSKLHLG------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------LGLVVGFTLVLAIICTILAWKTRKLP--
----------------------------------------------------------DNFSEARYIFICSFSTLVIVAL
SVPGYYSTVG----------------------------------------------------------------------
--------------------------------------------------------LLQATFASIAVITFGLSILLLLFI
PKIYTILFRPDLNTKEAMLRSIQEFTFGADTRIHTKPK------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNB1
--------------------------------------------------------------------------------
--MTPGAL--LMLLGALGAPLAP-------------------------------------------GVRGSEAEGRLREK
LFSG---YDSS-------------------------------------VRP-AREVGDR---------------------
--VRVSVGLILAQLISLN--------------------------------------------------------------
-----EK-DEEMSTKVYLD-------------------------------------------------------------
----------------------------------------------LEW-TDYRLSWDPAE-------------------
--HDG---IDSLRITAESVWLPDVVLLNN------NDGNFDVA-----LDISVVVSSDGSVRWQPPGIYRSSCS----IQ
VT-------YFPFDWQNCTMVFSSYSYDSSE----VSLQTGLGPDGQGHQEIH-------------------IHEGTFI-
-ENGQWEIIHKPSRLIQPPGDPR------------------GGREGQRQEVIFYLIIRR---------------------
--------------------KPLFYLVNVIAPCILITLLAIFVFYLPPDAG-------------------EKMGLS----
IFALLTLTVFLLLL----------------------ADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPH
--THQMPLWVRQIFIH-------------KLPLYLRLKRPKPERDLMPEPPHCS---SPGSG------------------
------------WGRGTDEYFIRKP-PSDFLFPKPNR-------------------------------------------
--------------------------------------------------------------------------------
FQP-----------------------------------------------------------------------------
--------------------------------------------------------ELSAPDLRRFIDGPNRAVALLP--
------------------------------------------------------------------ELREVVSSISYIAR
QLQEQEDHD-----------------------------------------------------------------------
------------------------------------------------------ALKEDWQFVAMVVDRLFLWTFIIFTS
VGT-LVIFLDATYHLPPPDPFP----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gorilla_gorilla_CHRNB1
--------------------------------------------------------------------------------
----MTPGALLMLLGALGAPLAP-------------------------------------------GVRGSEAEGRLREK
LFSG---YDSS-------------------------------------VRP-AREVGDR---------------------
--VRVSVGLILAQLISLN--------------------------------------------------------------
-----EK-DEEMSTKVYLD-------------------------------------------------------------
----------------------------------------------LEW-TDYRLSWDPAE-------------------
--HDG---IDLLRITAESVWLPDVVLLNN------NDGNFDVA-----LDISVVVSSDGSVRWQPPGIYRSSCS----IQ
VT-------YFPFDWQNCTMVFSSYSYDSSE----VSLQTRLGPDGQGHQEIH-------------------IHEGTFI-
-ATS--------SLTSYLPG--------------------------------QYIIVIE---------------------
--------------------KSVFEWP-----GNMITDYAIELSFSSALQG-------------------EKMGLS----
IFALLTLTVFLLLL----------------------ADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPH
--THQMPLWVRQIFIH-------------KLPLYLRLKRPKPERDLMPEPPHCS---SPGSD------------------
------------WGRGTDEYFIRKP-PSDFLFPKPNR-------------------------------------------
--------------------------------------------------------------------------------
FQP-----------------------------------------------------------------------------
--------------------------------------------------------ELPAPDLRRFIDGPNRAVALLP--
------------------------------------------------------------------ELREVVSSISYIAR
QLQEQEDHD-----------------------------------------------------------------------
------------------------------------------------------ALKEDWQFVAMVVDRLFLWTFIIFTS
VGT-LVIFLDATYHLPPPDPFP----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRNB1
--------------------------------------------------------------------------------
----MALGALLLLLGVLGTPLAP-------------------------------------------GARGSEAEGQLIKK
LFSN---YDSS-------------------------------------VRP-AREVGDR---------------------
--VGVSIGLTLAQLISLN--------------------------------------------------------------
-----EK-DEEMSTKVYLD-------------------------------------------------------------
----------------------------------------------LEW-TDYRLSWDPAE-------------------
--HDG---IDSLRITAESVWLPDVVLLNN------NDGNFDVA-----LDINVVVSFEGSVRWQPPGLYRSSCS----IQ
VT-------YFPFDWQNCTMVFSSYSYDSSE----VSLKTGLDPEGEERQEVY-------------------IHEGTFI-
-ENGQWEIIHKPSRLIQLPGDQR------------------GGKEGHHEEVIFYLIIRR---------------------
--------------------KPLFYLVNVIAPCILITLLAIFVFYLPPDAG-------------------EKMGLS----
IFALLTLTVFLLLL----------------------ADKVPETSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPH
--THQMPFWVRQIFIH-------------KLPPYLGLKRPKPERDQLPEPHHSL---SPRSG------------------
------------WGRGTDEYFIRKP-PSDFLFPKLNR-------------------------------------------
--------------------------------------------------------------------------------
FQP-----------------------------------------------------------------------------
--------------------------------------------------------ESSAPDLRRFIDGPTRAVGLPQ--
------------------------------------------------------------------ELREVISSISYMAR
QLQEQEDHD-----------------------------------------------------------------------
------------------------------------------------------ALKEDWQFVAMVVDRLFLWTFIVFTS
VGT-LVIFLDATYHLPPPEPFP----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNB1_a
--------------------------------------------------------------------------------
------MKAQDWIIVTCCLCGLGA------------------------------------------MTGATEMEDKLMKK
LFSA---YNSK-------------------------------------VRP-ARNPEER---------------------
--VVVRIGMILSSFVSLN--------------------------------------------------------------
-----MK-DEEMNTIVMMN-------------------------------------------------------------
----------------------------------------------LEW-NDYRLSWNPKD-------------------
--YGG---VDVLRISSGKVWLPDIVLINN------NDGVFGVA-----LQVHVQAYSNGRVTWTPPALYKSSCG----VK
VT-------YFPFDWQNCTMVFRSYTYDSSE----VDLQHALDKRGKEIKEII-------------------LDTGFS--
-ESGEWHIRHKVSRKNVR--------------------------EDLYEDITFYLIIER---------------------
--------------------KPMFYVVNIVLPCILITIIAIFNFYLPPDAG-------------------EKMGLS----
INVLLTLTVFLLLL----------------------ANKIPETSLGVPIIVNYLMITMILVTFSVILSVVVLNLHHRSPN
--THQMPLWVRKIFIH-------------MLPPYLGMLRPKVETPLFLEKPAKKE---NIQA------------------
------------ISRVADEYFIRKPSNMNFLFPKPHR-------------------------------------------
--------------------------------------------------------------------------------
YQP-----------------------------------------------------------------------------
--------------------------------------------------------DGQCTDLRKFIDGPSHYLTLPP--
------------------------------------------------------------------ELKTAVEAITYIAE
QLQAEKDYE-----------------------------------------------------------------------
------------------------------------------------------ALKEDWQYVAMVADRLFLWIFVIFTT
LGT-LGIFTDASFNATPTDPFP----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNB1_a
--------------------------------------------------------------------------------
----STMKYLLLLPLSCCLCSLIP------------------------------------------LGGASEVEKTLMKT
LFSN---YTLK-------------------------------------VRP-AISPEQR---------------------
--VVVRVGMILSSFVGLN--------------------------------------------------------------
-----MK-NEEMSTIVVMN-------------------------------------------------------------
----------------------------------------------LEW-TDYRLSWSPKQ-------------------
--YGG---IEVLRIPSGKVWLPDIVLINN------NDGVFHVA-----LHVHVQVYSNGRVTWTPPALYCSSCG----VK
VE-------YFPFDWQNCSMQFRSYTYDSTE----IDVQYALNLRGQEIREIQ-------------------LDEAFT--
-EGGEWYIKHRPSRKVML--------------------------DDEYEGMVFYLIIER---------------------
--------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAG-------------------EKMGLS----
INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVNYIMLTMILVTFSVILSVVVLNLHHRSPN
--THQMPMWVRKIFIH-------------LLPPYLCMMRPKVEAPLYLEALPRREK--KVTT------------------
------------VSKVADEYFIRKP-DMSVLFPKPNR-------------------------------------------
--------------------------------------------------------------------------------
FHS-----------------------------------------------------------------------------
--------------------------------------------------------EGLCTDLRKFIDGPSSYLSLPE--
------------------------------------------------------------------ELKSAIEAITYIAE
ALQAEKDYE-----------------------------------------------------------------------
------------------------------------------------------ALKKDWQYVAMVVDRMFLWIFVIFTT
VGT-LAIFAEASFNRAPANPFP----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNB1_b
--------------------------------------------------------------------------------
------TSYLLFTQL--IFGVLLL------------------------------------------LAGASEVEKTLMKT
LFSN---YTLK-------------------------------------VRP-AISPEQR---------------------
--VVVRVGMILSSFVGLN--------------------------------------------------------------
-----MK-NEEMSTIVVMN-------------------------------------------------------------
----------------------------------------------LEW-TDYRLSWSPKQ-------------------
--YGG---IEVLRIPSGKVWLPDIVLINN------NDGVFHVA-----LHVHVQVYSNGRVTWTPPALYCSSCG----VK
VE-------YFPFDWQNCSMQFRSYTYDSTE----IDVQYALNLRGQEIREIQ-------------------LVYNISP-
-EGGEWYIKHRPSRKVML--------------------------DDEYEGMVFYLIIER---------------------
--------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAG-------------------EKMGLS----
INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVNYIMLTMILVTFSVILSVVVLNLHHRSPN
--THQMPMWVRKIFIH-------------LLPPYLCMMRPKVEAPLYLEALPRREK--KVTT------------------
------------VSKVADEYFIRKP-DMSVLFPKPNR-------------------------------------------
--------------------------------------------------------------------------------
FHS-----------------------------------------------------------------------------
--------------------------------------------------------EGLCTDLRKFIDGPSSYLSLPE--
------------------------------------------------------------------ELKSAIEAITYIAE
ALQAEKDYE-----------------------------------------------------------------------
------------------------------------------------------ALKKDWQYVAMVVDRMFLWIFVIFTT
VGT-LAIFAEASFNRAPANPFP----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNB1_b
--------------------------------------------------------------------------------
---------------------------------------------------------------------AFEVESALLKN
LFSN---YTLK-------------------------------------VRP-AVSPEQR---------------------
--VVVRVGMILSSFVGLN--------------------------------------------------------------
-----MK-NEEMSTIVVMN-------------------------------------------------------------
----------------------------------------------LEW-TDYRLSWSPKD-------------------
--YDG---IEVLRIPSGKIWLPDIVLINN------NDGVFEVA-----LQVHVQVYSNGRVTWTPPALYCSSCG----VK
VE-------YFPFDWQNCSMQFRSYTYDSTE----IDIQYALDSKGREIKEIQ-------------------LDEAYT--
-EGGEWYIKHRPSRKVML--------------------------DDEYEGMVFYLIIER---------------------
--------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAG-------------------EKMGLS----
INVLLTLTVFLLLL----------------------ADK-PETSLGVPIIVNYIMFTMILVTFSVILSVVVLRLHHRSHN
--THQMPMWVRRIFIH-------------LLPPYLCMMRPQVETPLYLEVLPRREK--KIPA------------------
------------SSKVADEYFIRKP-DLSVLFPKPNR-------------------------------------------
--------------------------------------------------------------------------------
FHS-----------------------------------------------------------------------------
--------------------------------------------------------DGLCTDLRKFIDGPSSYLSLPE--
------------------------------------------------------------------ELKSAIEAITYIAE
ALQAEKDYE-----------------------------------------------------------------------
------------------------------------------------------ALKKDWQYVAMVVDRMFLVLFVIFTT
VGT-LAIFTQASFNRSPGNPFPVTPDTWFL--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNB1_a
--------------------------------------------------------------------------------
---------------------PLC------------------------------------------PTGASDMEKTLLKK
LFTD---YNLK-------------------------------------VRP-ASSPEER---------------------
--VVVRVGMVLSSFVGLN--------------------------------------------------------------
-----MK-NEEMSTIVVMN-------------------------------------------------------------
----------------------------------------------LEW-TDHRLSWKREE-------------------
--YDG---IEVMRIPAGKVWLPDIVLINN------NDGVFDVA-----LHVHVQAYSNGRVTWTPPALYCSSCG----VK
VT-------YFPFDWQNCTMQFQSYTYDSTE----IDVQYALDSKRNEIREIQ-------------------LDEAYT--
-EGGEWTIKHKPCRKNMN--------------------------DDQYEVMTFYLIIER---------------------
--------------------KPLYYVLNIILPCILITIIAIFNFYLPPDAAPG-----------------EKMGLS----
INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVNYIMFTMILVTFSVILSVVVLNLHHRSPS
--THMMPMWVRKIFIH-------------LLPPYLYMLRPKVETPLSLEFMPRREK--KVFT------------------
------------ISK-ADEYFIRKP-DSSILFPKPNR-------------------------------------------
--------------------------------------------------------------------------------
FHP-----------------------------------------------------------------------------
--------------------------------------------------------EGMCTDLRKYIDGPSSYLTLPD--
------------------------------------------------------------------ELKSAIEAITFIAE
ALQAEKDFE-----------------------------------------------------------------------
------------------------------------------------------ALREDWQYVAMVVDRMFLWIFVIFTT
VGT-LAIFADASFHRTPTDPFK----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNB1_a
--------------------------------------------------------------------------------
-------MTLLFPVGHLGVPYRSR------------------------------------------LLGAAQVEQALMKS
LFSD---YNLK-------------------------------------VRP-AHVPESR---------------------
--VVVRVGMILSSFVGLN--------------------------------------------------------------
-----MK-NEEMSTTVVMN-------------------------------------------------------------
----------------------------------------------LEW-TDYRLTWNPKQ-------------------
--HDG---IKMLRVPSGKVWLPDIVLINN------NDGVFDVA-----LRVHVLVYSDGRITWTPPALYLSSCG----VK
VT-------YFPFDWQNCTMQFRSYTYDSTE----IDLQYALDSKGKEIREIQ-------------------LDEGFS--
-ESGEWHIRHKPSRKIMK--------------------------DDLYEEMTFYLIIER---------------------
--------------------KPLY-----------------FNFYLPPDAG-------------------EKMGLS----
INVLLTLTVFLLLL----------------------ADKIPETSLGVPIIVKYIMFTMILVTCSVILSVVVLNLHHRSPN
--THMMPMWIRKIFLH-------------MLPPYLFMRRPKQENLQYLESVPRREM--KVMA------------------
------------ISKAADEYFIRKP-DSSILFPKPNR-------------------------------------------
--------------------------------------------------------------------------------
FHS-----------------------------------------------------------------------------
--------------------------------------------------------DGMYTDLRKFIDGPSTYLALPD--
------------------------------------------------------------------ELKTAIDAITYIAE
ALQAEKDYE-----------------------------------------------------------------------
------------------------------------------------------ALKEDWQFVAMVVDRMFLWIFVVFTT
LGT-LAIFIDASFNHTPKDPFK----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Ciona_intestinalis_CHRNB1
--------------------------------------------------------------------------------
-------MINCLLIFLLLPITKTS------------------------------------------AAKFESTEGRLANY
LLNG---YNPQ-------------------------------------FRPYNKKYENK---------------------
--TFVDVMMTLSQIISVK--------------------------------------------------------------
-----EK-SQEFTTSVYMQ-------------------------------------------------------------
----------------------------------------------YDW-LDDRFGWVPDD-------------------
--YDG---ITTVRIPCASIWVPRIVLQNS------IDGNFDVS-----LRTNALIQHDGKVSWLPPALYKSTCT----IE
VA-------LFPFDWQNCTMVFRSATYDRTE----MEFGIPI-DTVYIDLSA-------------------------FQ-
-SNGEWDILQRPVKINSNEN------------------------DKTYQDITFYFIIRR---------------------
--------------------KPQFYIINLIIPCILMSSLSCFVFYLPSISC-------------------EKMTLS----
ISILLGETVFLFLI----------------------AQRMPETSLAVPLIAGYLLFVMILVIISVICSVVVCNVHYRSNT
--THSMPDWIVWIFME-------------KLAPLLKVERPSEEESGACSARPR----RCSSVS-----------------
------------TRKAMKQRSEWKP-PSEILFDHQAS-------------------------------------------
-----------------------------------------------------------------------------RLG
FRARHYLNEYGMTGI-----------------------------------------------------------------
--------------------------------------------------------NVAAPENGSFVPPSFKKLPKG---
-------------------------------------------------------------------FQPAADSIDYIAN
QKKEENEMG-----------------------------------------------------------------------
------------------------------------------------------QSQDDWGYVALILDRLLLWVYLATFT
LGT-LFFFLQTKFAYYPEKLN-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNE
--------------------------------------------------------------------------------
MARAPLGVLLLLGLLGRG-VGKNE-------------------------------------------------ELRLYHH
LFN---NYDPG-------------------------------------SRPVREPEDT----------------------
--VTISLKVTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTSVWIG-------------------------------------------------------------
----------------------------------------------IDWQDYR-LNYSKDD-------------------
--FGG---IETLRVPSELVWLPEIVLENN------IDGQFGVA-----YDANVLVYEGGSVTWLPPAIYRSVCA----VE
VT-------YFPFDWQNCSLIFRSQTYNAEE----VEFTFAVDNDGK-------------------TINKIDIDTEAYT-
-ENGEWAIDFCPGVIRRHHGGA-------------------TDGPG-ETDVIYSLIIRR---------------------
--------------------KPLFYVINIIVPCVLISGLVLLAYFLPAQ-AGG-----------------QKCTVS----
INVLLAQTVFLFLI----------------------AQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQR-TP
TTHA-MSPRLR----HVL---------LELLPRLLGSPPPP-EAPRAASPP-----------------------------
--------------------RRASSVGLLLRAEELIL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KKPRSELVFEGQRHRQGT--------
---------------------------------------------------WT-AAFCQSLGAAAPEVRCCVDAVNFVAE
STRDQEATGEEVS-------------------------------------------------------------------
----------------------------------------------------------DWVRMGNALDNICFWAALVLFS
VGSSLIFLGAYFNRVPDLPYAPCIQP------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Mus_musculus_CHRNE
--------------------------------------------------------------------------------
MAGALLGALLLLTLFGRS-QGKNE-------------------------------------------------ELSLYHH
LFD---NYDPE-------------------------------------CRPVRRPEDT----------------------
--VTITLKVTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTSVWIG-------------------------------------------------------------
----------------------------------------------IDWHDYR-LNYSKDD-------------------
--FAG---VGILRVPSEHVWLPEIVLENN------IDGQFGVA-----YDSNVLVYEGGYVSWLPPAIYRSTCA----VE
VT-------YFPFDWQNCSLIFRSQTYNAEE----VEFIFAVDDDGN-------------------TINKIDIDTAAFT-
-ENGEWAIDYCPGMIRRYEGGS-------------------TEGPG-ETDVIYTLIIRR---------------------
--------------------KPLFYVINIIVPCVLISGLVLLAYFLPAQ-AGG-----------------QKCTVS----
INVLLAQTVFLFLI----------------------AQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLR-TP
TTHA-TSPRLR----QIL---------LELLPRLLGSSPPP-EDPRTASPA-----------------------------
--------------------RRASSVGILLRAEELIL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KKPRSELVFEGQRHRHGT--------
---------------------------------------------------WT-AALCQNLGAAAPEIRCCVDAVNFVAE
STRDQEATGEELS-------------------------------------------------------------------
----------------------------------------------------------DWVRMGKALDNVCFWAALVLFS
VGSTLIFLGGYFNQVPDLPYPPCIQP------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Bos_taurus_CHRNE
--------------------------------------------------------------------------------
MAGALLCALLLLQLLGRG-EGKNE-------------------------------------------------ELRLYHY
LFD---TYDPG-------------------------------------RRPVQEPEDT----------------------
--VTISLKVTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTSVWIG-------------------------------------------------------------
----------------------------------------------IDWQDYR-LNYSKGD-------------------
--FGG---VETLRVPSELVWLPEIVLENN------IDGQFGVA-----YEANVLVSEGGYLSWLPPAIYRSTCA----VE
VT-------YFPFDWQNCSLVFRSQTYNAEE----VEFVFAVDDEGK-------------------TISKIDIDTEAYT-
-ENGEWAIDFCPGVIRRHDGDS-------------------AGGPG-ETDVIYSLIIRR---------------------
--------------------KPLFYVINIIVPCVLISGLVLLAYFLPAQ-AGG-----------------QKCTVS----
INVLLAQTVFLFLI----------------------AQKTPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLR-TP
TTHA-MSPRLR----YVL---------LELLPQLLGSGAPP-EIPRAASPP-----------------------------
--------------------RRASSLGLLLRAEELIL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KKPRSELVFEQQRHRHGT--------
---------------------------------------------------WT-ATLCQNLGAAAPEIRCCVDAVNFVAS
STRDQEATGEEVS-------------------------------------------------------------------
----------------------------------------------------------DWVRMGKALDSICFWAALVLFL
VGSSLIFLGAYFNRVPQLPYPPCM--------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Danio_rerio_CHRNE_a
----------------------------------------------------------------------------MAVA
ERFGRTCVVAIALLATVLQVTGNE-------------------------------------------------ESQLIAD
KFK---NYSKN-------------------------------------IRPARHADEK----------------------
--VKVQVKLTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTNVWIE-------------------------------------------------------------
----------------------------------------------IQWHDYR-LAWNTSE-------------------
--YHD---IEQIRVPYYTVWLPDIVLENN------IDGKFDVA-----YYANVLISSDGSMYWLPPAIYRSTCA----IE
IT-------YFPFDWQNCTLVFRSQTYSANE----IDIVLAEDENGK-------------------PIEWVDIDPEAFT-
-ENGEWAIKHRPARKLTNQRYS-------------------PDDLE-YQEVYYNIIIQR---------------------
--------------------KPLFYVINIILPCSLISSLVVLAYFLPAK-AGG-----------------QKLTVS----
ISVLLAQTVFLILI----------------------SQKIPETSLSVPLIGKYLIFVMSMTTLIVTNCIIVLNYSLR-SP
STHN-MSQSIK----HIF---------LEVVPRYLGMAPFVDEGDQ-GGVYE----------------------------
-----------------MRERRRSSFGLMQRAEEYVL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KQPRSEMMFDKQRERHGLMRTI----
---------------------------------------------VDEIDVSSTANLYKSLAKTAPEIKECVDACNFIAE
STKQQNDTGSEME-------------------------------------------------------------------
----------------------------------------------------------SWVLIGKMIDKVCFWAAISLFS
IGTIAIFLMGHYNQAPEYPFAWENKKYVPE--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Takifugu_rubripes_CHRNE_a
--------------------------------------------------------------------------------
---SLLGSQSLVS--LFRAVQSNE-------------------------------------------------ETELIKD
LFK---DYNKN-------------------------------------IRPVVHPEDK----------------------
--VEVQIKLTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTNVWIE-------------------------------------------------------------
----------------------------------------------IQWLDYR-LSWNESK-------------------
--YYG---IQVIRVPCKTVWLPDIVLENN------IDGKFDVA-----YYANVLISSNGWMYWLPPAIYRSTCS----IE
IT-------YFPFDYQNCTLAFRSQTYSANE----VDLILALTEENG-------------------TIEWVDIDPEAFT-
-ENGEWAIVHRPARKMVNMRYS-------------------PDDLE-YQEILFNLVIQR---------------------
--------------------KPLFYIINLILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS----
ISVLLAQTVFLFLI----------------------AQKVPETSLSVPLIGKYLIFVMCVTTLIATNQIVVLNFSLR-SP
NTHT-MSQTIK----HVF---------LEMVPRFLCMPPLVDESEATTEVNG----------------------------
-----------------IRERRRSSFGLMQRAEEYVL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KQPRSEMMFDKQRERHGLT-------
-----------------------------------------------------TANLYKSLAQAAPEIKQCVDACNFIAD
SKRQQNTIGSEIE-------------------------------------------------------------------
----------------------------------------------------------SWVLIGKMIDKVCFWAAILLFI
IGTVAIFLMGHFNRAPDFPFPGQNKK------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Tetraodon_nigroviridis_CHRNE_a
--------------------------------------------------------------------------------
----------------------NE-------------------------------------------------ETELIKD
LFK---DYNKK-------------------------------------IRPVVHPEDK----------------------
--VEVQIKLTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTNVWIE-------------------------------------------------------------
----------------------------------------------IQWIDYR-LSWNESE-------------------
--YYG---INIIRVPCKTVWLPDIVLENN------IDGKFDVA-----YYANVLVSSNGGMYWLPPAIYRSTCA----IE
IT-------YFPFDYQNCTLAFRSQTYSANE----VELILTIGEKNE-------------------TIEWVDIDPEAFT-
-ENGEWAIVHRPARKVINTRYS-------------------PDDLE-YQEIMFNLVIQR---------------------
--------------------KPLFYIINVILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS----
ISVLLAQTVFLFLI----------------------AQKVPETSLSVPLIGKYLIFVMCVTTLIATNQIVVLNFSLR-SP
STHT-MSQTIK----HVF---------LELVPRLLCMPPLVDEGEATAVVNG----------------------------
-----------------IRERRRSSFGLMQRAEEYVL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KQPRSEMMFDKQRERHGLTRSI----
---------------------------------------------VDNIDVTSTANLYKSLAQAAPEIKQCVDACNFIAD
SIRQQNTIGSEIE-------------------------------------------------------------------
----------------------------------------------------------NWVLIGKMIDKVCFWAAILLFI
IGTVAIFFMGHFNRAPDFPFPGEDKKYVPS--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Gasterosteus_aculeatus_CHRNE_a
-----------------------------------------------------------------------------MAE
SRFWIFFGVVAVLGTLTARVQCNE-------------------------------------------------ESELIRD
LFK---GYNKN-------------------------------------IRPVVHPEDK----------------------
--LTIQIKLTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTNVWIE-------------------------------------------------------------
----------------------------------------------IQWVDYR-FVWNTSN-------------------
--YHG---IDVIRVPCKTIWLPDIVLENN------IDGKFDVA-----YYANVLISYDGSMYWLPPAIYRSTCA----IE
IT-------YFPFDYQNCTLAFRSQTYSANE----VDLILAVGDEME-------------------TIEWVDIDPQAFT-
-ENGEWAIVHRPGRKMINPRYT-------------------PDDLE-YQEILFNLVIQR---------------------
--------------------KPLFYIINIILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS----
ISVLLAQTVFLFLI----------------------AQKIPETSLSVPLIGKYLIFVMSVTTLIATNQIVVLNFSLR-SP
STHT-MSNTIK----HVF---------LEMVPRFLGMPPLVDDTEVTTVVNG----------------------------
-----------------VRERRRSSFGLLQRAEEYVL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KQPRSEMMFDKQRERHGLTRSI----
---------------------------------------------VDDMDVSSTANLYKSLAQAAPEIKQCVDACNFIAE
STRQQNSIGSEIE-------------------------------------------------------------------
----------------------------------------------------------SWVLIGKMIDKVCFWAAISLFI
IGTVWIFLTGHFNRAPEFPFPGQSKKYVPS--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Oryzias_latipes_CHRNE_a
--------------------------------------------------------------------------------
---MPVFSSPLLQYIMIEIVHCNE-------------------------------------------------ESQLIGD
LFR---NYNKN-------------------------------------IRPVEHPEDK----------------------
--VQVMIKLTLTNLISLNE-------------------------------------------------------------
-----K--EETLTTNVWIE-------------------------------------------------------------
----------------------------------------------IQWTDYR-LVWNTSQ-------------------
--YYG---IKTIRVPYNTVWLPDIVLENN------IDGKFDVA-----YYANVLISNEGWMYWLPPAIYRSTCA----IE
IT-------YFPFDYQNCTLAFRSQTYSAKE----VDLVLATGDEDV-------------------TIEWVDIDPEAFT-
-ENGEWAIVHRPARKVINTRYS-------------------PDDLE-YQEIIFNLVIQR---------------------
--------------------KPLFYIINVILPCSLISSLVVLAYFLPAQ-AGG-----------------QKLTVS----
ISVLLAQTVFLFLI----------------------AQKTPETSLAVPLIGKYLIFVMCVTTLIATNQIVVLNFSLR-SP
STHT-MSYSIK----HLC---------LEMVPRFLGMSPLVDDSEVTAEVNG----------------------------
-----------------IRERRRSSFGLMQRAEEYVL-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------KQPRSEMMFDKQRERHGLTRSI----
---------------------------------------------VDNIDVSSTANLYKSLAQAAPEIKQCVDACNFIAE
STKQQNDIGSVXE-------------------------------------------------------------------
----------------------------------------------------------SWVLIGKMIDKVCFWAAMLLFS
-GTVGIFLTGHVNKAPEFPFPGEDKKYVP---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Homo_sapiens_CHRNA5
-------------------------------------------------------------------------MAARGSG
PRALR-LLLLVQLVAGRCGLAGAA---------------------------------GGAQRGLSEPSSIAKHEDSLLKD
LF--QD-YERW-------------------------------------VRPVEHLNDK----------------------
--IKIKFGLAISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWIDVK-LRWNPDD-------------------
--YGG---IKVIRVPSDSVWTPDIVLFD------NADGRFEG------TSTKTVIRYNGTVTWTPPANYKSSCT----ID
VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDQD----------------------------VDKRDFF-
-DNGEWEIVSATGSKGNRTDSC--------------------C---WYPYVTYSFVIKR---------------------
--------------------LPLFYTLFLIIPCIGLSFLTVLVFYLPSNEG-------------------EKICLC----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSS
-THNAMAPLVRKIFLH-------------TLPKLLCMRSHVD--------------------------------------
---------------------RYFTQKEETESGS----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------GPKSSRNTLEAALDSIRYITR
HIMKEND-------------------------------------------------------------------------
------VRE----------------------------------------------VVEDWKFIAQVLDRMFLWTFLFVSI
VGS-LGLFVPVIYKWANILIPVHIGNANK---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------
>Xenopus_tropicalis_CHRNA5
--------------------------------------------------------------------------------
-------MPWCAEYLLWLFLCLDI---------------------------------LHGACGISEPSYIAKSEDRLFKY
LFQQQD-YQRW-------------------------------------VRPVEHLNDT----------------------
--VKVKFGLAITQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWVDVK-LRWDPNE-------------------
--FAG---ITSIRVPSDSIWIPDIVLYD------NADGRFEG------SVTKAVVRYDGTINWTPPANYKSSCT----ID
VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDYH----------------------------VDKRDFF-
-DNGEWEIVNATGNKGNRTDGC--------------------C---FYPYITYSFIIKR---------------------
--------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNEG-------------------EKISLC----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLVFTMIFVTLSIVLTVFAINIHNRSSA
-THNAMAPWVRKIFLH-------------KLPKLLCMRSHVD--------------------------------------
---------------------RYFTRKDETGKVR----------------------------------------------
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-----------------------------------------------------------GPESSRNTLEAALDSIRYITR
HVMKEHE-------------------------------------------------------------------------
------VQE----------------------------------------------VVEDWKFVAQVLDRMFLWTFLLVSV
IGS-LFLFIPVIHKWANIIVPVHIGNMYGDKNT-----------------------------------------------
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>Danio_rerio_CHRNA5_a
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-----MVTALSLVRALLPLVCSAV---------------------------------LCSAIGPPMLSSYAKTEDKLFKH
LFS--N-YQKW-------------------------------------VRPIEDLNTT----------------------
--IQVKFGLAISQLVDVD--------------------------------------------------------------
-----EK-NQLMTTNVWMK-------------------------------------------------------------
----------------------------------------------QEWTDLK-LRWDPDH-------------------
--YLG---ITSIRVPSDSIWIPDIVLYD------NADGNFEA------TVTKAVVRFDGTISWTPPANYKSACT----ID
VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDILLEDVH----------------------------VDKRDYF-
-DNGEWEIVKATGNRGLRRDGT--------------------F---FYPSITYSFIIRR---------------------
--------------------LPLFYTLFLIIPCIGLSFLTVLVFYLPSNGG-------------------EKISLC----
TSVLVSLTVFLLVI----------------------EEIIPSSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSS
-THHSMAPWVRRIFLH-------------HLPRLLCMRSHVD--------------------------------------
---------------------RYATSAGTRTGGLG---------------------------------------------
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---------------------------------------------------------YGKSLSQD---------------
----------------------------------------------------------TNQLDAEHNLQAALESIRYITR
HVVKENE-------------------------------------------------------------------------
------VRE----------------------------------------------VVQDWKFVAQVLDRVFLWAFLLVSL
LGS-ALLFIPVIYKWASIIVPSYAEITS----------------------------------------------------
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>Takifugu_rubripes_CHRNA5_a
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-------STEIRISMTVNLWVITV---------------------------------FLHLLEVPKLSSCAKAEDKLFKY
LFG--N-YQKW-------------------------------------VRPVDHLNQT----------------------
--IRVKFGLAISQLVDVD--------------------------------------------------------------
-----EK-NQRMTTNVWMK-------------------------------------------------------------
----------------------------------------------QEWTDMK-LRWNPEE-------------------
--YAG---ITIIRVPSDRIWRPDVVLYDK-----SSDGRFEG------TITKAVVKYDGTITWTAPANYKSACT----ID
VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDFH----------------------------VDKRDYF-
-DNGEWEIVKATGSRGLRMDGS--------------------T---SYPTITYFFIIRR---------------------
--------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGG-------------------EKISLC----
TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIVITVFAINVHHRSSS
-THNDMAPWVRRVFLH-------------HLPKLLCMRSHVD--------------------------------------
---------------------RYATSGAARTRGL----------------------------------------------
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--------------------------------------------------------------------------------
-------------------------------------------------------GMAEGSEPEL---------------
----------------------------------------------------------TPLFYTRQNLKAALDSIRYITM
HVVKENE-------------------------------------------------------------------------
------VREYPHARGLSQQVSKSLNSFQAQTCSQTCRFLPSIDMKKKKAKEIHFKVVQDWKFVAQVLDRMFLWAFLLVSI
LGS-ALLFIPVIYKWASIIV------------------------------------------------------------
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>Tetraodon_nigroviridis_CHRNA5_a
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---------------------------------------------------------------VPKLSSYAKAEDKLLKY
LFG--N-YQKW-------------------------------------VRPVDHLNQT----------------------
--IRVKFGLAISQLVDVD--------------------------------------------------------------
-----EK-NQRMTTNVWMK-------------------------------------------------------------
----------------------------------------------QEWTDMK-LRWSPEE-------------------
--YVG---ITIIRVPSDRIWRPDVVLYD------NSDGRFEG------TVTKAVVKHDGTITWTAPANYKSACT----ID
VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDFH----------------------------VDKRDYF-
-DNGEWEIVKATGSRGLRTDGS--------------------A---SYPTITYFFIIR----------------------
--------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGG-------------------EKISLC----
TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIVITVFAINVHHRSSS
-THNDMAPWVRRVFLH-------------RLPKLLCMR-HVD--------------------------------------
---------------------RYATSGASRARAL----------------------------------------------
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--------------------------------------------------------------------------------
-------------------------------------------------------GMAEST-PEL---------------
----------------------------------------------------------TPLLYSRQSLKAALDSIRYITM
HVVKENE-------------------------------------------------------------------------
------VRE----------------------------------------------VVQDWKFVAQVLDRMFLWAFLLVSI
LGS-AILFIPVIYKWASIIVPNHETMVFGN--------------------------------------------------
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>Gasterosteus_aculeatus_CHRNA5_a
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---------------------------------------------------------MCHSLRVPKLSSFAKAEDKLFKY
LFG--N-YQKW-------------------------------------VRPVEYLNQT----------------------
--ISVKFGLAISQLVDVD--------------------------------------------------------------
-----EK-NQQMTTNVWMK-------------------------------------------------------------
----------------------------------------------QEWIDRK-LRWNPDD-------------------
--YLG---ITTIRVPSNRIWLPDVVLYD------NSDGRFEA------TVTKAVVKYNGTISWTPPANYKSACT----ID
VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDITLEEFH----------------------------VDKKDYF-
-DNGEWEIVKATGSRGLRTDSS--------------------S---TYPTITYFFIIRR---------------------
--------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGG-------------------EKISLC----
TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSS
-THHNMAPWVRRIFLH-------------RLPKLLCMRSHAD--------------------------------------
---------------------RYATAGVARTGGAERE-------------------------------------------
--------------------------------------------------------------------------------
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-------------------------------------------------------GKMKDSAPEL---------------
----------------------------------------------------------TSLLYTKHNLQAALESIRYITM
HVVKENE-------------------------------------------------------------------------
------VRE----------------------------------------------VVQDWKFVAQVLDRMFLWAFLLVSI
LGS-ALLFIPVIYKWANIIVPKHFGS------------------------------------------------------
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>Oryzias_latipes_CHRNA5_a
--------------------------------------------------------------------------------
---------------------------------------------------------------VPKLSSYAKAEDTLFKH
LFG--T-YQKW-------------------------------------VRPIEYLNQT----------------------
--IPVKFGLAISQLVDVD--------------------------------------------------------------
-----EK-KQLMTTNVWLK-------------------------------------------------------------
----------------------------------------------QEWIDMK-LRWKPED-------------------
--YLG---ITTIRVPSDRIWLPDVVLYD------NSDGRFEG------TVTKAVVKYDGTISWNPPANFKSACT----ID
VT-------FFPFDLQNCSMKFGSWTYDGSQ----VDIILEDFH----------------------------VDKKDYF-
-DNGEWEIVKATGSRGLRTDGS--------------------T---SYPTITYFFIIRR---------------------
--------------------LPLFYTLFLIIPCIGLSFLTILVFYLPSNGN-------------------EKISLC----
TSVLVSLTVFLLVI----------------------EEIIPSSSKAIPLIGEYLVFTMIFVTLSIIITVFAINIHYRSSS
-THHDMAPWVRRIFLH-------------RLPKLLCMRSHVD--------------------------------------
---------------------RYATAGLAGKGKVTVQ-------------------------------------------
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-------------------------------------------------------EKTKDSTPDL---------------
----------------------------------------------------------THILHTRHNLQTALESIRYITM
HVVKENQ-------------------------------------------------------------------------
------VRE----------------------------------------------VVQDWKYVAQVLDRMFLWAFFLVSV
LGS-ALLFVPVIYKWASIIVPDYAGS------------------------------------------------------
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