>Homo_sapiens_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVALVLSWTHLTI---SSRGIKGKRQRRISAEGSQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCKEGLYL-------------------HKGRCYPACP-------EGSSAANGTMECSSP------------
------------------------------------AQCEMSE-------------------------WSPWGPCSKKQ-
---------------------QLCGFRRGSEERTRRVLHAPVGDHA-----------------------ACSDTKETRRC
TVR-RVPCP----------------------------------------EGQKRRKGGQGRRENANRNLARK--------
--ESKEAGAGSRRRKGQQQQQ--QQGTVGPLTSAGPA-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Gorilla_gorilla_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVALVLSWTHLTI---SSRGIKGKRQRRISAEGSQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCKEGLYL-------------------HKGRCYPACP-------EGSSAANGTMECSSP------------
------------------------------------AQCEMSE-------------------------WSPWGPCSKKK-
---------------------KLCGFRRGSEERTRRVLHAPVGDHA-----------------------ACSDTKETRRC
TVR-RVPCP----------------------------------------EGQKRRKGGQGRRENANRNLARK--------
--ESKEAGAGSRRRKGQQQQQ--QQGTVGPLTSAGPA-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Macaca_mulatta_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVALVLSWTHLTI---GSRGIKGKRQRRISVEGSQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCKEGLYL-------------------HKGRCYPACP-------EGSSAANGTMECSSP------------
------------------------------------AQCEMSE-------------------------WSPWGPCSKKK-
---------------------KLCGFRRGSEERTRRVLNAPGGDHA-----------------------ACSDTKETRRC
TVR-RVPCP----------------------------------------EGQKRRKGGQGRRENANRNLARK--------
--ESKEAGTGSRRRKGQQQQQ--Q-GTVGPLTSAGPA-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Mus_musculus_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVALVLSWTHIAV---GSRGIKGKRQRRISAEGSQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCQEGLYL-------------------HKGRCYPACP-------EGSTAANSTMECGSP------------
------------------------------------AQCEMSE-------------------------WSPWGPCSKKR-
---------------------KLCGFRKGSEERTRRVLHAPGGDHT-----------------------TCSDTKETRKC
TVR-RTPCP----------------------------------------EGQKRRKGGQGRRENANRHPARK--------
--NSKEPGSNSRRHKGQQQPQ---PGTTGPLTSVGPTWAQ----------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Oryctolagus_cuniculus_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVALTLSWVHLAA---GSRGIRGKRQRRISAEGSQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERSDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCREGLYL-------------------HKGRCYPACP-------EGSTASNGTLECGSP------------
------------------------------------AQCEMSE-------------------------WSPWGPCSKKK-
---------------------KLCGFRRGSEERTRRVLHAPAGDHT-----------------------ACSDTKEARRC
TVR-RTPCP----------------------------------------EGQKRRKGGQGRRENTHRNLARK--------
--DSKETGAGSRRRKGQQQQP----GTARPFTTAGPT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Bos_taurus_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVALVLSWMHLAA---GSRGIKGKRQRRISADGGQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCQESLYL-------------------HKGRCYPACP-------EGSAPADGTMECSSP------------
------------------------------------AQCEMSE-------------------------WSLWGPCSKKK-
---------------------KLCGFRRGLEERTRRVLHAPGGDHA-----------------------VCSDTKETRKC
TVR-RTPCP----------------------------------------EGQKRRKGSQGRRENANRNPGRK--------
--ESKEAGTGARRRKGQQQQQ---QGTEGPVTSLGPT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Dasypus_novemcinctus_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVVLVLSWMHLAA---GSRGTKGKRQRRISVEGSQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCKESLYL-------------------HKGRCYPACP-------EGSAAANGTMECSSP------------
------------------------------------AQCEMSE-------------------------WSPWGPCSKKK-
---------------------KLCGFRRGSEERTRRVLHVPAGDHA-----------------------ICSDTRETRRC
TVQ-RTPCP----------------------------------------EGQKRRKGGQGRREKVNRNPDRK--------
--ESKEAGTGSRRRQGLQQPQ--QQGTAGPVTSAGPT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Myotis_lucifugus_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRLG---LCVVALVLSWMHLTA---GSRGIKGKRQRRISAEGSQAC----------------------
-------------------------------------AKGCELCS------------------------EVNGCLKCSPK
LFILLERNDIR------------------QVGVC---------------------------------------LPSCPPG
YFDARNPD-------------------MNKCIKCKIEHCEACFS------------------------------------
----HNFCTKCKESLYL-------------------HKGRCYPACP-------EGSAAANGTMECSSP------------
------------------------------------AQCEMSE-------------------------WSLWGPCTKRK-
---------------------KLCGFRRGSEERTRRVLHAPGGDHA-----------------------ICSDTKEIRRC
TVR-RTPCP----------------------------------------EGQKRRKGGQGRREKANRNPSRK--------
--ESKEAGTGSRRRKGQQQPQQQQQGTVGPLTSAGPT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Ornithorhynchus_anatinus_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQLG---LFAVLVILSWTDLAG---GSKVAKGKRQRRISTEVSQGC----------------------
-------------------------------------AKGCELCS------------------------EFNGCLKCSPK
LFILLERNDIR------------------QIGIC---------------------------------------LPSCPPG
YYDARNPD-------------------MNKCIKCKIENCDACFS------------------------------------
----QNFCTKCKEGLYL-------------------HKGRCYPDCP-------SGYSAANGTMECSSP------------
------------------------------------AHCEMSE-------------------------WSSWGPCSKKK-
---------------------KLCGFRKGTEERARRVLNAPTGDRS-----------------------GCPPAREVRRC
TVQ-KSLCP----------------------------------------EGPKRRKDEQGKRENGNGNHNRK--------
--EAKEARSGSRRRKGQQQQQQQQRGTVLPLTLAGPD-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Gallus_gallus_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQLG---LFVVVVFLSSMDLTG---GSKVVKGKRQRRISTELSQGC----------------------
-------------------------------------ARGCDLCS------------------------EFNGCLRCSPK
LFILLERNDIR------------------QIGIC---------------------------------------LPSCPLG
YFGLRNTD-------------------MNKCIKCKIENCESCFS------------------------------------
----RNFCTKCKEGLYL-------------------HKGRCYVTCP-------EGYSAANGTMECSSP------------
------------------------------------AQCEMSE-------------------------WGPWGPCSKKR-
---------------------KLCGFKKGNEDRTRRILQAPSGDVS-----------------------LCPATTEVRRC
TVQ-KSQCP----------------------------------------EGKRKKKDEQGKQDNTNGNRNRK--------
--DTKDAKSGTKKRK------SKQRGAVAPTTSASPAQ------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Pelodiscus_sinensis_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQLG---LFLVVVFLSLMDLAG---SSKVVKGKRQRRISSEVSQGC----------------------
-------------------------------------AKGCDLCS------------------------EFNGCLKCSPK
LFILLERNDIR------------------QIGIC---------------------------------------LPSCPLG
YFGVRNPD-------------------MNKCIKCKIENCEACFS------------------------------------
----RNFCTKCKEGLYL-------------------HKGRCYSTCP-------EGYSAANGTMECSNP------------
------------------------------------AQCEMSE-------------------------WGPWGPCSKKR-
---------------------KLCGFKKGNEERSRKVLLAPSGDVS-----------------------VCPATTEVRKC
TVQ-KNQCP----------------------------------------EGKRKRKEEQEKRDNMNGNRNQK--------
--DTKEAKSGTKKRK------SQQRGTVVPMTLASPAQ------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Xenopus_tropicalis_RSPO1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQFG----LFAVLVLILMDIAD---SNKFVKGRRHRRRSTEVSMVC----------------------
-------------------------------------AKGCDLCS------------------------EFNGCMKCLPK
LFILLERNDIR------------------QTGIC---------------------------------------LQSCPQG
YFDDRNRE-------------------NNRCLKCKINNCETCFS------------------------------------
----KNFCTKCKEGFYS-------------------HKGSCYSSCP-------EGFSAVNGTAECSS-------------
------------------------------------VQCEMSE-------------------------WGAWSPCSRTG-
----------------------QCGRKKGTEERSRIVVKAPLGDLA-----------------------LCPPTTERRKC
TMP-KIPCT----------------------------------------NRSLGMLKNQNKQELSKRKKEKN--------
--SKTQIEQDGSLKRNKSQQK----VTSIPSTPSLPVQ------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Danio_rerio_RSPO1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MHLG--LLALALVFFSSMGHAD---NLKASKARRQRRISTEVPPSC----------------------
-------------------------------------SNGCEHCS------------------------EYNGCLKCRPR
LFILLERNDIR------------------QIGIC---------------------------------------LAACPVG
YYGIRNRD-------------------MNKCTQCKIENCEACFS------------------------------------
----RNFCTKCKEGLYS-------------------HRGRCFSSCP-------EG-FTVNGTMECVVQ------------
--------------------------------------CDLSE-------------------------WSPWGPCMKKN-
---------------------KTCGFKKGNQTRTREPL-QVPSPATSTGA---------------APASGCVPEIQTQRC
TVQKKIPCK----------------------------------------G-----ENKKNQQNRGENSKNRG--------
--RDSKERGGNKKRKNTNRST-----TVPTITTSMVT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Takifugu_rubripes_RSPO1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQLG--LVVLAMIFLSSMGHSD---ALKLSKARRQRRVSPEMPLSC----------------------
-------------------------------------PKGCDRCS------------------------EYNGCIKCKPK
LFIFLERNDIR------------------QIGVC---------------------------------------LASCPIG
YFGMRNPEG------------------NNRCTQCKIENCEACFN------------------------------------
----RNFCTKCKEGLYS-------------------HSGRCYVSCP-------QDQSAVNETMECV--------------
-------------------------------------DCELGE-------------------------WSQWSSCMKKN-
---------------------KTCGFRKGSQSRSRVPLPQVHSPDTSLAL---------------VPSQTCAPETERKKC
TLSKKAPCG----------------------------------------RERNGKGDQQGDTNRRERENGRG--------
--HGRNKGGGSRRKKGQSRTT-----SAPSITTSSVS-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Gasterosteus_aculeatus_RSPO1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQLG--LVALAMVFVSSVGHGD---ALRPSRGRRQRRVSTEGPPSC----------------------
-------------------------------------PKGCDRCS------------------------EYNGCIKCRPK
LFIFLERNDIR------------------QIGVC---------------------------------------LASCPVG
YFGMRNPEG------------------NNRCTQCKIDNCEACFN------------------------------------
----RNFCTKCKEGLYS-------------------HSGRCYVSCP-------PGQRTANESMECVGQRA----------
------------------------------------DECILGE-------------------------WSQWGSCMKKN-
---------------------KTCGFKKGSQSRERVPS-QVHSPDASPAP---------------EPSQTCAPQVERRKC
SVT-KTPCA----------------------------------------R---GKRKIH---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Oryzias_latipes_RSPO1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQLG--LVALAMIILSSMGHSD---VVKLSKARRQKRVSTEGPPSC----------------------
-------------------------------------PKGCDRCS------------------------EYNGCVKCKPK
LFIFLERNDIR------------------QVGVC---------------------------------------LASCPVG
YFGMRNPEG------------------NNRCTQCKIDNCEACFN------------------------------------
----RNFCTKCKEGLYS-------------------HSGRCYVSCP-------PGQRTANETMECVGQHA----------
------------------------------------LKCELGK-------------------------WSQWSSCMKKN-
---------------------KTCGFKKGSQFRVRVPLQQTYAADSSSTL-----------------EETCTSQSERRKC
VVP-KTPCV----------------------------------------KDRKNKGDNTNRRENRRGLGREG--------
--KDGSRGGGGKRRRGPSRTT-----TVPSITTSSVT-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Homo_sapiens_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG
YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------
----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLEETMECV--------------
------------------------------------EGCEVGH-------------------------WSEWGTCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPVKDTI-----------------------LCPTIAESRRC
KMT-MRHCP----------------------------------------GGKRTPK------AKEKRNKKKK--------
---------RKLIERAQEQHSVFLATDRANQ-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Pongo_abelii_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG
YYGHRAPD-------------------MNRCA------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------KGCEVGH-------------------------WSEWGTCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC
KMT-VRHCP----------------------------------------GGKRTPK------AKEKRNKKKK--------
---------RKLTERAQEQHSVFLATDRANQ-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Mus_musculus_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRFC--LFSFALIILNCMDYSQ-CQGN---RWRRNKRASYVSNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG
YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------
----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLDETMECV--------------
------------------------------------EGCEVGH-------------------------WSEWGTCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC
KMA-MRHCP----------------------------------------GGKRTPK------AKEKRNKKKR--------
---------RKLIERAQEQHSVFLATDRVNQ-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Rattus_norvegicus_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MRFC--LFSFALIILNCMDYSQ-CQGN---RWRRSKRASYVSNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG
YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------
----KDFCTKCKAGFYL-------------------HRGRCFDECP-------EGFAPLDETMECV--------------
------------------------------------EGCEVGH-------------------------WSEWGTCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC
KMA-MRHCP----------------------------------------GGKRTPK------AKEKRNKKKR--------
---------RKLIERAQEQHSVFLATDRVNQ-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Canis_familiaris_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG
YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------
----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLDETMECV--------------
------------------------------------EGCEVGH-------------------------WSEWGTCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC
KMA-MRHCP----------------------------------------GGKRAPK------AKEKKNKKKK--------
---------RKLIERAQEQHSVFLATDRANQ-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Bos_taurus_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------MDYSH-CQGN---RWRRSKRASYVSNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG
YYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------
----KDFCTKCKVGFYL-------------------HRGRCFEECP-------DGFAALDETMECV--------------
------------------------------------EGCEVGH-------------------------WSEWGTCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC
KMA-MRHCP----------------------------------------GGR-----------KPDNNIGKK--------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Pteropus_vampyrus_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQFR--LFSFALIILNCMDYSH-CQGN---RWRRSKRASYVSNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPSG
FYGHRAPD-------------------MNRCARCRIENCDSCFS------------------------------------
----KDFCTKCKVGFYL-------------------HRGRCFDECP-------DGFAPLDETMECV--------------
------------------------------------EGCEVGH-------------------------WSEWGTCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC
KMA-MRHCP----------------------------------------GGRRAPK------AKEKKNKKKR--------
---------RKLTERAQEQHSVFLATDRADQ-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Ornithorhynchus_anatinus_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------ASYGANPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCSRCQQK
LFFFLRREGMR------------------QYGEC---------------------------------------LHSCPLG
YYGLRSPD-------------------MNRCARCRIENCDSCFS------------------------------------
----RDFCTKCKAGSFL-------------------HRGRCFDECP-------DGFAPLEETMECV--------------
------------------------------------EGCEVGP-------------------------WSEWGVCSRNN-
---------------------RTCGFKWGLETRTRQIVKKPAKDTI-----------------------PCPTIAESRRC
KMA-LRHCP----------------------------------------GGK----------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Anolis_carolinensis_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQFR--LFSFALIVLNCMDYSH-CQGA---RWRRSKRANYGPNPIC----------------------
--------------------------------------KGCLSCS------------------------KDNGCIRCQHK
LFFFLRREGMR------------------QYGEC---------------------------------------LNSCPSG
YYGLRAPD-------------------MNRCSRCRIENCDSCFS------------------------------------
----RDFCTKCKPGFYL-------------------YRGRCFGECP-------DGFMPLEETMECV--------------
------------------------------------EGCEVGP-------------------------WSEWGICSRNN-
---------------------KTCGFKWGLETRTRQIVKKPAKDTL-----------------------PCPTIAESRRC
KMA-LRHCP----------------------------------------GG--KRT------PKTKDKKKKK--------
---------KNLMERAQKQHSLFLSTDRAGQ-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Xenopus_tropicalis_RSPO2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MQFQ--LFSFVLIILNCVDYSH-CQAN---RWRRSKRASYGTNPIC----------------------
----