>Human_WIPF1
----MPVPPPPA--------------------PPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKT-VTNDRS
APILDKPKGAG--AGGGGG----GFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQ--AGMPKLRSTANRDN-DSGGS--
RPPLLPPGGR---STSAKPFSPPSG--------------PGRFPVPSPGHRSGPPEPQRNRMPPP-RPDVGSKPDSIPPP
VPSTPRPIQSSPHNRG---SPPVP-GGPRQPSPGPTPPPFPGNRGT----------------------------------
-------------------------------------ALGGGSIRQSPLSS--SSPFSNRPPLPPTP--SR---------
-ALDDKPP--PPPPPVGNRPSIHREAVPPPPP-QNNKPPVPSTPRPSASSQAPPPPPPPSRPG-----PPPLPPSSSG--
-N-DETPRLPQRNLSLSSSTPP-LPS-------------------------------PGRSGPLPPPPSE--------RP
PPPVRD-PPGRSGPLPPPPP-VSRNGSTSRALPATPQLPSRSGV----DSPRSGP--RPPLPPDRPSA------------
-GAPPPPPP---------------------------------------------------------STSIRNGFQDSPCE
---DEWESRFYFHPISDLPPPEPYVQTTKS----------YPSKLARNESR--SGSNRRERGAPPLPPIPR---------
---------
>Mouse_WIPF1
----MPVPPPPA--------------------PPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKT-VTNDRS
APILDKPKGAGASAGGYGG----GGGGGGG-GGGGGGGSGGNFGGGGPPGLGGLFQ--AGMPKLRSTANRDN-DSGGS--
RPPILPPGGR---ATSAKPFSPPSG--------------PGRFPAPSPGHRSGPPEPPRNRMPPP-RPDVGSKPDSLPPP
VPNTPRPVPSSLHNRG---SPAGL-GAPR--------PPFPGNRGA----------------------------------
-------------------------------------AFGAGSARQNPSGS--SSPFP-RPPLPPTP--SR---------
-ALDDKPP--PPPPPVGNRPSMHREAVPPPPS-QTSKPPVPSTPRPGLGSQAPPPPPPPSRPG-----PPPLPPAS----
-N-DEIPRLPQRNLSLTSSAPP-LPS-------------------------------PGRSGPLPPPPSE--------RP
PPPVRD-PPGRSGPLPPPPP-INRNGSTARALPATPQLPSRSGM----DSPRSGP--RPPLPPDRPGA------------
-GAPPPPPP---------------------------------------------------------STSVRNGFQDSSCE
---DEWESRFYFHPISDLPPPEPYVPTTKT----------YPSKLARNESR--SGSNRRERGAPPLPPIPR---------
---------
>Rat_WIPF1
----MPVPPPPA--------------------PPPPPTFALANTEKPSLNKTEQAGRNALLSDISKGKKLKKT-VTNDRS
APILDKPKGAG---GGYGG----GSGGGGG-GGSSGGG--GNFGGGGPPGLGGLFQ--AGMPKLRSTANRDN-DSGGS--
RPPILPPGGR---ATSAKPFSPPSG--------------PGRFPAPSPGHRSGPPEPPRNRMPPP-RPDVGSKPDSLPPP
VPNTPRPIPSSLHNRG---SPAGL-GAPR--------PPFPGNRGA----------------------------------
-------------------------------------AFGAGSVRQNLSSS--SSPFP-RPPLPPTP--SR---------
-ALDDKPP--PPPPPVGNRPSMHREAVPPPPS-QNSKPPVPSTPRPGAGSQAPPPPPP-SRPG-----PPPLPPTS----
-S-DEIPRLPQRNLSLTSPTPP-LPS-------------------------------PGRSGPLPPPPTE--------RP
PPPVRD-PPGRSGPLPPPPP-INRNGSTARALPATPQLPSRSGM----DSPRSGP--RPPLPPDRPGA------------
-GAPPPPPP---------------------------------------------------------STSVRNGFQDSSCE
---DEWESRFYFHPISDLPPPEPYVPTTKT----------YPSKVARSESR--SGSNRRERGAPPLPPIPR---------
---------
>Opossum_WIPF1
----MPVPPPPA--------------------PPPPPTFALANTEKPSLNKSEQAGRNALLSDINKGKKLKKT-VTNDRS
APILDKPKGSGGGGSGFGG----GSG-TGGFGGSCGGASGGGFGGSGPPGLGGLFQ--AGMPKLRSTANRDT-DSGGI--
RPPILPPGGR---ATSAKPFTPPGG--------------VGRFPTPSPGHRSGPPEPLRNRMPPPPRPDLSSKPDSGPPP
VPSTPRPTQSNLHNRG---SPPVPSGIHRQPSLGPTPPPFPGNRSA----------------------------------
-------------------------------------GFG-GSVRQSSPGS--SSPFSNRPPLPPAP--SR---------
-AMDDKPP--PPPPPMGNRPAINREGAPPPPPPQNNKPPVPSTPRPSSSSQAPPPPPP-SRPG-----PPPVPPVSIG--
-N-DETPRLPQRNLSLTSSAPL-LPS-------------------------------PGRSGPLPPPPNE--------RP
PPPVRD-PPSRSGPLPPPPP-INRNGNTSRALPSTPQLPSRGGL----ENQRGGP--RPPLPPDRPGS------------
-GALPPPPP---------------------------------------------------------SSSMRNGFQDLSCE
---DEWESRFYFHPLSDLPPPEPYVPMTKS----------YPSKVARNESR--SGSNRRERGAPPLPPIPK---------
---------
>Platypus_WIPF1
----MPVPPPPA--------------------PPPPPTFALANTEKPSLNKSEQAGRNALLSDISKGKKLKKA-VTNDRS
APILDKPKGGGGGGGGFGG----GSSGGGGSGGGFGGG-------GGPPGLGGLFQ--SGMPKLRSTANRDN-DSGGS--
RPPILPPGGR---AMSAKPFSPPSG--------------PPRFPGSSPGHKGGAPELQRSRMPPPPRPDASCKPDGGPPP
IPNTPRPFQSSFHNRG---SPPVP-GVPRQPNLGPTPPPFPGHRNP----------------------------------
-------------------------------------ASG-GSIRQSSPGP--PSPFFNRPPLPPAP--GR---------
-AMEDKLP--PPPPPLGNRPMINREGAPPPPP-QNNKPPVPSTPRPTTTSQAPPPPPPPSRPG-----PPAFPPGSGG--
-G-DEIPRLPQRNLSLTSSGPL-LPS-------------------------------AGRSGPLPPPPME--------RP
PPPVRE-PPSRSGPLPPPPP-INRNGNIARASPA-PQLPSRGGL----ETQRGGP--RPPLPPDRPGS------------
-GAPPPPPPP--------------------------------------------------------SSSIRNGFQDSPCE
---DEWESRFYFHPVSDLPPPEPYVPMNKN----------YPSKLARSESR--SGSSRRERGAPPLPPIPR---------
---------
>Chicken_WIPF1
----MPVPPPPA--------------------PPPPPTLALANTEKPTLSRSEQAGRNALLSDITKGKKLKKT-VTNDRS
APILDKPKGSSGGGGGFGG---------GGGGSSGGG-----FSGGGPPGLGGLFQ--AGMPKLRSAASRDA-DTGAA--
RPPALPPGAR---SAAAKPFSAPSG--------------PPRFPGPPLGQRSPAADPQRSRLPPP-RPDVGSKPEATPPP
VPSTPRPIASSLHGRG---SAPAP-VLNRQPSLGPTPPPFPGSRAA----------------------------------
-------------------------------------GSA-GSLRQPGPGP--ATPYSGRPPLPPTP--GRS--------
-PVDEKPP--PPPPPSGHRPTASRDMALPPPPPQNSKPPVPASPRPPLGVPAPPPPPS--RPG-----PPPVPPGPAS--
-S-DEMPRLPQRNLSLVPPAAP-SSG-------------------------------SGRSGPLPPPPSE--------RP
PPPIRD-PPSRAGPLPPPPP-ISRNGSTSRALPAAPQLPSRAGL----ENQRGGP--RPPLPPDRPGT------------
-GAPPPPPPP--------------------------------------------------------SAALRNGFQES-GD
---DEWESRFSFHPISDLPPPEPYVPVNRS----------YPSKLARNENR--GGSARKERGVPPLPPIPR---------
---------
>Anolelizard_WIPF1
----MPVPPPPA--------------------PPPPPTLSVANTEKPSLNKSEQAGRSALLSDITKGKRLKKA-VTNDRS
APVIDKPKGLGGGGGGGGGFTSSGGGGGGGGGSSGSSSSSNSYSGGGPPGLGGLFQ--AGMPKLRST-NRDN-DSVGS--
RASVFPPGGW---ATSAKPFSAPGV--------------IGRFPGPSPSQRTPAMEPQRSRMPPP-RPDAGSRPDTGAPP
VPNTPWPIPSSLHNRG---APLLP-GTSRQASLGLTPPPFPGNR------------------------------------
--------------------------------------FG-GSMRQTSPGSPSSSPSSNRPPLPPAP--AR---------
-PIDEKPP--PPPPPAGNRPPLSREPSLPPPPPQNNKPPVPSTLRPSFGSPVRPPPLP-NRPG-----PPPVPPMFGG--
-N-DEMPRLPQRNISLASPAPPTLTS-------------------------------SGRSGPLPPPPNE--------RP
PPPVRD-PPSRSGSFPPPPPPINRNGCTLRALPATPQLPSRGGF----EKHRGGS--VPPLPPDRPGS------------
-GAPPPPPPPP-------------------------------------------------------SSAMRNGFQDSSCE
---DEWESRFSFHPLSDLPPPEPYVPINKS----------YPSKLGRNDNR--SGSSRRERGAPPLPPIPR---------
---------
>Zebrafish_WIPF1
----MPIPPPPP--------------------PPPPPTFSQANTEKPVLNRSEQQGRNALLSDISKGARLKKA-VTNDRS
APVLDKPKGGGG-----PGGGGGGGGGGGGFGGGGGGG------GGGGGGLGGLFQ--GGMPKLRSTR----DDSVSV--
RPPVLPPVAR---TTGPRPFGGGSGS-------------APRLP----VQRSESFDPPRARMT-PPRPET---PGGPPPP
LPSAPRPFQSSTQSRG---PPALPGTPRFGSAPTPPPPTLP-GRQPAPPPV-----------------------------
-----------------------------------PGGIG---RP--PSVPSPSTGHAGRPPPPPAP--GRG--------
----EDRP--PPVPPANRSMPLTRD-SPPPPP-----PPSASSKPTPPPAPSPACLRPPVSAA-----PPLPPGRPSPNT
PD-EHTPRLPERNLSLASHPPA--PP-------------------------------PGRSGPLPPPPSE--------RP
PALGRN-ASGRSGPLPPPPPSGR-PGGGSMRSSPAPPPPNRPGV----ETHRGG--SRPPLPPDRPSS------------
-G-PLPPPP----------------------------------------------------------APIGNGYHSQHHI
---DEWESRFTFRPVSDLPPPDPYIPCQKT----------YPSKIVRNESR---GSGKKERGAPPLPPIPR---------
---------
>Fugu_WIPF1
--------------------------------------------------------------------------------
------------------------------------------------------------MPKLRSAASRESNDSAPS--
RAPVLPPGGR---SCAPTPFGGGG---------------PPKLPGAPPSSRGSVPDLPRGRP--NVRQDT---PGGAPPP
IPSTPRPHH-GIQSQGSPSPPSLPG--RPSPS--PAPPSVPPGRHGPLPPL-----------------------------
-----------------------------------PGGHSPGSRAGFAAAPPPPVPNGGRPPLPPTP-GGKS--------
-QFSDDRPPLPPVPAGGYRPTANRD-TPPLPPSFNSKPVSSSSSPASRPLLGGPPPIPPGRPG-----PPPIPPIPSG-A
DD-HSVPRLPQRNSSLNSHGPS--TP-------------------------------HGRSGPLPPPPNE--------RP
PALGRNQSSVRSGPLPPPPSSARSIGGGSMRSSAAPSPIVRPGL----DPPRGGPGGRPPLPPDRPGI------------
-GGPLPPPP----------------------------------------------------------P-MGNGFQNSHHN
QIQDEWECRFNFHPASDFPPPEPYIPCQKT----------YPSKLTKTDGRVLSGSGKKERGAP--PPVPR---------
---------
>Stickleback_WIPF1
-----PPPPPPP--------------------PGPPPTFSIANTEKPSLNRSEQSGRNALLSDIAKGSRLKKA-VTCDRS
GPLLDSKSTSAWSHKPKGGGGGGGGGGGGGGGGGGGGG------GGAPAGLGGLFA--GGIPKLRSAGSAAS-DSAPS--
RGPVFPPGGR---SGGPTPFGGGGGS-----------TGPPKLPGAPAGGRGNVPDLPKGRPSFSSRQDT---PGG-PPP
VPNTPRPSQ-AFQPRGGLPPPALPGGPRPPPSSGPPPPGLPPGRQG-LPP------------------------------
-----------------------------------PGGSPAGPRPGFSAPLPPP-PNSSRPSLPPTPPGGRP--------
-PLPDDRP--PPPPLGGHRPSMPRD-VPPPPP-----PSGNSK----------PP--PPSRP--------PLPSVPRP-E
GA-RPPYRLADR-APLLSRPPR--LA-------------------------------VTTT---TPPACP--------RG
TCRSAVHISSPKGPLPPLPPSGRGVGGGSLRSLPPPSPIGRPGP----EPPRGGTGSRPPLPPDRPGV------------
-GGAPPPPP----------------------------------------------------------AHMGNGFQNSHHN
---QEWEYRFTFHPVSDLPPPEPYVHFQKT----------YPSKLGKTDGR--AGAGKNERGAPPLPPLPR---------
---------
>Human_WIPF2
MPIPPPPPPPPG--------------------PPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRS
APILEKPKGSSGGY---------------------------GSGGAALQPKGGLFQ--GGVLKLRPVGAKDGSENLAG--
KPALQIPSSR---AAAPRPPVSAAS---------------GRPQDDTDSSRASLPELPRMQR----------------PS
LPDLSRP--------N----TTSSTGMKHSSSAPPPPPPG---RRANAPP------------------------------
--------------------------------------TPLPMHSS------KAPAYNREKPLPPTP--GQR---LHPGR
EGPPAPPPVKPPPSPVNIRTGPSG--QSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES
-----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSASPSLLSN-RP
PPPARD-PPSRGAAPPPPPP-VIRNGARDAPPPPPP--YRMHGS----EPPSRGK---PPPPPSRTPA------------
-GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR
SFLDDFESKYSFHPVEDFPAPEEYKHFQRI----------YPSK----TNR------AAR-GAPPLPPILR---------
---------
>Mouse_WIPF2
MPIPPPPPPPPG--------------------PPPPPTFNQANTEQPKLSRDEQRNRGALLQDICKGTKLKKVTNVNDRS
APVIEKPRGSSGGY---------------------------GPGAAALQPKGGLFQ--GGVPKLRPVGAKDASEAPAG--
KPALQVPSSR---AAAPRPPGSAAS---------------GRPHDDTDSNRASLPELPRMQR----------------PS
LPDLSRP--------N----TASGTGMKHSSSAPPPPPPG---RRANAPP------------------------------
--------------------------------------TPLPLHSN------KAQAYNREKPLPPTP--GQR---LHPGR
EGHPAPPPVKPPPSPVNIRTGPSG--QSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES
-----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSATPSLLSN-RP
PPPARE-PPSRGAAPPPPPP-MIRNGARDAPPPPPP--YRMHGS----EPPSRGK---PPPPPSRTPA------------
-GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR
SFLDDFESKYSFHPVEDFPAPEEYKHLQRV----------YPSK----TNR------AAR-GAPPLPPILR---------
---------
>Rat_WIPF2
MPIPPPPPPPPG--------------------PPPPPTFSQANTEQPKLSRDEQRNRGALLQDICKGTKLKKVTNINDRS
APVIEKPKGSGGGY---------------------------GPGAAALQPKGGLFQ--GGVPKLRPVGAKDAPETPAG--
KPALQVPSSR---AAAPRPPVSAAS---------------GRPHDDSDSSRASLPELPRMQR----------------PS
LPDLSRP--------N----TTSGTGMKHSSSAPPPPPPG---RRANAPP------------------------------
--------------------------------------TPLPLHSN------KAQAYNREKPLPPTP--GQR---VHPGR
EGHPAPPPVKPPPSPVNVRTGPSG--QSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES
-----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSATPSLLSN-RP
PPPARD-PPSRGAAPPPPPP-MIRNGARDAPPPPPP--YRMHGS----EPPSRGK---PPPPPSRTPA------------
-GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR
SFLDDFESKYSFHPVEDFPAPEEYRHLQRV----------YPSK----TNR------AAR-GAPPLPPILR---------
---------
>Opossum_WIPF2
MPIPPPPPPPPG--------------------PPPPPTFNQANIEPPKLSRDEQRGRGALLQDICKGTRLKKVTHINDRS
APVLEKPKGGSGGY---------------------------GSGINALQSKGGLFQ--GGVPKLRPVGTKDISENLAG--
KTVLQVSGSR---ATAPRPPVSTGS---------------NRPQDDSDSSRASPPELPRMQR----------------PS
LPDLSRP--------N----STSSTGMKHSSSAPPPPPPG---RRANAPP------------------------------
--------------------------------------APLPMHSN------KAPTYNREKPLPPTP--GQR---PPPGR
EGPPAPPPIKPPPSPVNIRTGPSGHNQSLAPP--------------------PPPYRQPPG-------VPNGPSSPTNES
-----APELPQRHNSLHRKTPG-----------------------------------LVRGLAPPPPTSASPSLQSS-RP
PPPARE-PPSRGAAPPPPPP-LIRNGARDAPPPPPP--YRLHGST---EPLNRGK---PPPPPSRTPA------------
-GPPPPPPPP---------------------------------------------------------LRNGHRDSIATVR
SFLDDFESKYSFHPVEDFPAPEEYKHFQRI----------YPSK----TNR------ATR-GAPPLPPIIR---------
---------
>Chicken_WIPF2
MPIPPPPPPPPG--------------------PPPPPTFSQANTEPPKLSREEQRGRGALLQDICKGTKLKKVTQINDRS
APILEKPKGGSGER---------------------------GAAGQAAPSRGRAVP--CCAWWLTPLS---LPADSSG--
KQTLQVPGSR---AAAPRPPVPASN---------------SRPQDDSDNSRASPPELPRTQR----------------PS
LPDLSRP--------G----TAGGTGMKHSSSAPPPPPPG---RRATAPP------------------------------
--------------------------------------APPPAHGP------KVSSYNREKPLPPTP--GQR---APAGR
DGPPAPPPVKPPPSPVSIRTGSGAQSQSLAPP--------------------PPPYRQPPS-------VPNGPSSPITES
-----APELPQRHNSLHRKTPG-----------------------------------PLRGLAPPPPASASPSLQSS-RP
PPPARD-PPSRGAAPPPPPPPALDPALQARAGPGAG--GALLGMDGGGGRAWGGR---VGSEQRRAAAGLWWLWWLWWLR
DGPSRALCPA---------------------------------------------------------AASGDFTQELLGV
GLCPRVGCGGGACSAVVPPGHRKERRLRAVGCLQGGPRRGAPGA----ARR------FALHGLLAPGSTRSGGGSH----
---------
>Anolelizard_WIPF2
--------------------------------------------------------------------------------
------------------------------------------------------------------------SDSPSG--
KQSLQVPGTR---SVAPRPAVSSSS---------------SRHQDDADNNRASPPELPRTQR----------------PS
LPDLSRP--------N----SASSAGMKHSSSAPPPPPPG---RRANAPP------------------------------
--------------------------------------APPSMHNS------KVPSYNREKPLPPTP--GQR---LPGNR
EGPPAPPPIKPPPSPVNLRTGPSSQGQSLAPP--------------------PPPYRQPPG-------VPNGPASPTNES
-----APELPQRHNSLHRKTPG-----------------------------------PARGMAPPPPPSASPSLQSS-RP
PPPARD-PPSRGAAPPPPPPPMIRNGGRDAPPPPPP--YRMHGSS---DPTSRGK---PPPPPTRTPV------------
-GPPPPPPP----------------------------------------------------------MRNGHRDSISTVR
SFLDDFESKYSFHPVEDFPAPEEFRHFQRI----------YPSK----TNR------ATR-GAPPLPPIPR---------
---------
>Zebrafish_WIPF2
MPIPPPPPPPAG--------------------PPPPPTLSQANTTPPKLSRDEAKGRGALLSDICKGARLKKTTGVNDRS
APLIEKPKGGGGGVSSSG-----------------------GGSSAPVQPVGGLFQ--GGVPKLRPVG-----DGSAG--
RSALHPHGTR---SAAPRPPGS-------------------QEDPDSPSQQVSPPESSRPQR----------------PS
LPDLSRS-----PAGG----NSPSTGMKHSSSAPPPPPPMS--RRGNAP-------------------------------
---------------------------------------PAPLQKA------NAPLYNREKPLPPTP--EQRGPSPAPVR
ENAP-PPPVKPPPSPASSRSSSSS-SSSLAPP--------------------PPPYRQQSG-------LSNGPSSPVNEA
-----APELPQRHNSLSKKPSAAGHT-------------------------------PTRGHAPPPPPSPTP--QAG-RP
PPPARE-PPGRGAAPPVPGQ-PSRNGRDAPPPPPPP--YRTHGTSS--DAPSRGK---PPPPPSRTPA------------
-GPPPPPPP----------------------------------------------------------IRNGH-TSIS--R
SFVDDFESKYSFHPLDDFPPPEEYRHFTKI----------YPSK----ANR------AVMRGAPPLPPVGR---------
---------
>Fugu_WIPF2
MPIPPPPPPPPG--------------------PPPPPTFNVANTSPPKLSSSETKGRGALLSDICKGAKLKKVGVVNDRS
APVLEKPGGGGSGGGGGSG----------GGGGSGGGGGGGGFGGGGPMGMGGLFQ--GGVPKLRPVGDGSAGGSVG---
RSALRPPGSR---ALAPRPPTGRSN---------------SPSPSE----RPIPS-DQRSHR----------------PS
LPDISRPPSSS--NSS----SSIGSGMKHSTSAPPPPPPFNRGGRPNAPP------------------------------
--------------------------------------TPKT---------SSSSSHSRDKPLPPTP--NRG--------
--PTPPSSLKPPSS--SSRPPTGG--SSAPPP--------------------PPPYRPHTSGG-----ISNGPSHTDAGG
-----APELPQRHNSLHKKQPSGNSS-------------------------------QGRSHAPPPPPSPSLSSQQAIRP
PPPARD-PPGRR-AAPQVPTPGSRNGGRDAPPPPPP--YRVHSSTTSESHSRGGK---PPPPPSSSSIS----SSSSSRT
PAGPPPPPPP---------------------------------------------------------MRNGH-SSISSSR
SNIDDFESKFNFHPVEDLPPPEDYRHFNKV----------YPSK----NNK------AMMRGAPPAPPVGR---------
---------
>Medaka_WIPF2
----------------------------------------QANNNPPKLNQGGAKGRGALLSDIHKGAKLKKV-VVNDRS
APIIER--GGGSSGGGFG--------------------------GGGPMGMGGLFQ--GGVPKLRPVGGKDHGPVVGSLG
RSALKPPGSR---PAAPRPPTGRSS---------------SPTPPN----RPSSSEPQRSHR----------------PS
LPDISHSHNSS-----------SSGGMKHSTSAPPPPPPFNRGNRGNAPQ------------------------------
--------------------------------------APAS----------------REKPLPPTP--QRA--------
--PAPSSTARPPSS--SSRPQPSG--SHAPPP--------------------PPPYRPHLSGG-----VSNGPSDVDGGG
-----APELPRRHNSLRKKHSSG-----------------------------------GRSQAPPPPPSPS--SQQGSRP
PPPARE-PPGRR-AVPPAPPPSSRNGGRDAPPPPPP--YRGHSSGGSEPQIRVGK---PPPPVSSSAP-------PSTRT
PAGPPPPPPP---------------------------------------------------------IRNGH-SSSSSSR
PNTDEFEAKFVFHPIEELPPPDDYKPFSKV----------YPSK----SNK------AMLRGAPPAPPVMR---------
---------
>Stickleback_WIPF2
LPLLLPPPSPSF--------------------SLVPP---QANTTPPKLGSSETKGRGALLSDICKGTRLKKVGVVNDRS
GPIIES----GFS-------------------------------GGAPMGMGGLFQ--GGVPKLRSVT----GPELH---
LSLLHPDGLVGG-SVGSRPPAG-SS---------------TPSPAN----KPSPPEHQRSHR----------------PS
LPDISRPPNNN----G----SSTGGGMKHSTSAPPPPPPFNRGGRSNAPP------------------------------
--------------------------------------APPTPNMKPHAPPSSSSSHSREKPLPPTP--HRG--------
--HTPPGPVKAPPS--STRPPTGG--SSAPPP--------------------PPPYRPHTSGS-----VANGPSQVDGGG
--GGGAPQLPQRHNSLHKKHTSGGGT-------------------------------QGRSHAPPPPPSPSPSSQQASRP
PPPARE-PPGRKSAAPQVPPSVSRNGGRDAPPPPPPPPYRVHSSVASEAHSRVGK---PPPPPSSSS------SSLSSRT
PAVPPPPPPP---------------------------------------------------------IRNGH-SSITSMK
SSVDDFESKFNFHPLEDLPPPEEYRHFSKV----------YPSK----TNKA-----AMMRGAPPAPPVGR---------
---------
>Tetraodon_WIPF2
MPIPPPPPPPPG--------------------PPPPPTFNVANTTPPKLSSSETKGRGALLSDICKGTKLKKVGVVNDRS
APVLEMIKSGGWSKRQG---------------------------GGGPMGMGGLFQ--GGVPKLRPVG----GGSVG---
RSALRPPGSR---AAAPRPPTGRSN---------------SPSPSE----RPAPS-DQRAHR----------------PS
LPDISRPPSSSG-SSS----SSIGSGMKHSTSAPPPPPPFNRGGRGNAPP------------------------------
--------------------------------------TPKA---------SSSSSHSREKPLPPTP--NRG--------
--PTPPSSVKPPSS--SSRPPTGG--SSAPPP--------------------PPPYRPHTAGG-----LSNGPSHTDAGG
-----APELPQRHNSLHKKQPSGNSS-------------------------------QGRSHAPPPPPSPSPSSQQGSRP
PPPARD-PPGRR-AAPQVPTQGSRNGGRDAPPPPPP--YRIHSSATSDSHSRGGK---PPPP----------------RT
PAGPPPPPPP---------------------------------------------------------MRNGH-SSVPSPK
SNIDDFESKFNFHPVEDLPPPEDYRHFAKV----------YPSK----SNK------AMMRGAPPAPPVGR---------
---------
>Human_WIPF3
MPVPPPPPPPLPPPPPP-----------LGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRS
APQIESSKG-----TNKEG----------------GGS-ANTRGASTPPTLGDLFA--GGFPVLRPAGQRDVAGGKTG--
------QGPG---SRAPSPRLP------------------NKTISGPLIPPASPRLGNTSEAH--------------GAA
RTAPPRPNV-----------PAPPPPT-----PPPPPPPLPPPLPSSSPIK-----------------------------
-----------------------------------TPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPP-------------
--PPPTPPPLPPASVLSDKAVKPQLAPLHLPP--------------------IPPP--LPLLP-----PCGYPGLKAE--
-PASPAQDAQEPP---APPPP-----------------------------LPPYASCSPRASLPAPP--LPGVNSS----
SETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGR--PGAGGGKLNPPPAPPARSPT------------
-TELSSKSQQATAWTPTQQPGGQLRNGSLHIIDDFESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRTPGPWLQAEAVG
QSSDDIKGRNSQVTQASCL-------------------------------------------------------------
---------
>Mouse_WIPF3
MPVPPPPPPPPPPPPPPPPPLGAPPPPPLGAPPPPPPPGPPVSTDTPSLRKPDLKGRSALLADIQQGTRLRKVTQINDRS
APQIEGSKG-----TSKEG----------------GAAGSNARGGNTPPALGDLFA--GGFPVLRPAGQRDVSGGKSG--
------QGPG---SRAPSPRLP------------------IKAISGPLPAPASPRLGNASETH--------------SSA
RPVPPRPSV-----------PAPPPPT--------PPPPPPPPLPPASPIK-----------------------------
-----------------------------------AQLVSPPAPPTKVNPSVVPPPLPCAPPLPPPP-------------
--P--TPPPLPPASALSDKAVRPQLAPLHLPP--------------------IPPP--LPLLP-----PCGYPGLHSE--
-PNSPAQEVREPP---APPPPPPPPPPPP---------------------LPTYASCSSRTAVAPPP--LPGANNSG---
SETPPPLPPKSPSFQT------QKALPTPPGAPGPQAILQKKRRG---PGTSGGKLNPPPAPPARSPT------------
-TELSSK---------SQQPGGQLRNGGQHAIDDFESKFTFHSMEDFPPPDEYKPCQKIYPSKVPRSRTPGSWLQAEAAG
QSSDDIKSRNSQLSLKALR-------------------------------------------------------------
---------
>Rat_WIPF3
MPVPPPPPPPLPPPPPP-----------LGAPPPPPPPGPPISTDAPSLRKSDLKGRSALLADIQQGTRLRKVTQINDRS
APQIESSKG-----TSKEG----------------GAAGSNARGGSTPPALGDLFA--GGFPVLRPAGQRDVAGGKTG--
------QGPG---SRAPSPRLP------------------TKAISGPLPAPASPRLGNASDTH--------------SSA
RPVPPRPSV-----------PAPPPPTTPPPPPPPPPPPPPPPLPPASPIK-----------------------------
-----------------------------------APSVSPPVPPTKGNPSAVPAPIPCVPPLPPPP-------------
--P--TPPPLPPASALSEKAVRPQLAPLHLPP--------------------IPPP--LPLLP-----PYGYPALHSE--
-PSSPAQDVREPP---APPPPPPPPPPPPPP------------------PLPTYASCSPRAAVAPPPPPLPGSSNSG---
SETPPPLPPKSPSFQT------QKALPTPPGAPGPQIILQKKRRG---PGAGGGKLNPPPAPPARSPT------------
-TELSSK---------TQQPGGQLRNGGQHVIG----------------------------------RTPGSWLQAEAAG
QSSDDIKTRNSQLSLKALR-------------------------------------------------------------
---------
>Microbat_WIPF3
MPIPPPPPPPPG--------------------PPPPPTFNQGNTEQIKLSRDEQRGRGNLLQDICKGTKLKKVT??????
??????PKGSGGGY---------------------------GSGAGALQPKGGLFQ--GGVPKLRHVGAKDVSENLAG--
KPALQVPSSR---AAAPRPPGSTAS---------------GRPQDDTDSGRASLPELPRMQR----------------PS
LPDLSRP--------I----TTSSPGMKHSSSAPPPPPPG---RRAAPP-------------------------------
---------------------------------------ALPMHS--------KAAYNRE-PLPPTP--GQR---LHPGR
DGPPAP????????????????SG--QSLAPP--------------------PPPYREVPG-------VPNGPSSPTNES
-----APELPQRHNSLHRKTPG-----------------------------------PVRGLAPPPPTSVSPSLQSN-RP
PPPARD-PPSRGAAPPPPPP-MIRNGARDAPPPPPP--YR-HGS----EPLSRGK---PPPPPSRTPA------------
-GPPPPPPPP---------------------------------------------------------LRNGHRDSITTVR
SFLDDFESKYSFHPVEDFPAPEEYKHFQRV----------YPSK----TNR------AAR-GAPPLPPILR---------
---------
>Opossum_WIPF3
MPVPPPPPPPLPPPPPP-----------TGAPPPPPPLAPPLSTEAPRPKKDAAQGRSALLADIQQGTRLRKVTQINDRS
APQIETSKG-----ANKEG----------------GGAAGNSKGG-NPQALGGLFA--GGFPVLRPAGQRDGSGKKSG--
------KGGG---SRAPSPRLP------------------TKIISSPVNPPASPRLGNAPEAS--------------AIS
RPVPPRPNM-----------PAPPPPTT----PPPPPPPLPPSTSLPAMVK-----------------------------
-----------------------------------PPLVSPPPLMTKTSTQIMVPPPP--PPTPPPP-------------
--P----PPLQ-----GEKAGKPLVGPLNLPP--------------------VPPP--LPLLP-----PCGFPGQVSDAA
SPASPQPELREPP---PPPPPPPPP-------------------------LPLYSSPTPRSSLSPAP--LPGSNNN----
---GDPLPLKSPKASL-------QSMPLPPIPPASQSTILVQKKR---PGRGAG--------PTR---------------
----------------------------------------------------------------------GSWLPTDATG
RGNEDIKGRNSQRLLLEIFQG-FIHSFLMT----------APGV------------------------------------
---------
>Anolelizard_WIPF3
MPVPPPPPPPPLPPSLS------------GGPPPPPPLPPSANSEPPKARREDSKSRSALLHEIQRGTRLRKVTQTNDRS
APQIESERR-----TSRDG----------------GNS--TSGRSDVPQALGNLFA--EGFPVLKPVGQRDLTGGKTG--
------KPCT---LRMP-PRSPDSQN-----------N-NEKANGNFHVTPESPRPTEQPETP--------------KAQ
PPTPTRPSI-----------PAP-----------PPPPPLPPSSSS----K-----------------------------
-----------------------------------PSLVFPPPPP-------LPPPLAESPDKLTSP-------------
--STAAAVSLP----HNEKLPKAQTSPLNMPP--------------------LPPPPPLPLTS-----PCGTSGRTNE--
-GSSSQTDVRTNPPLMSPPPPPPPP------------------------HMSTFS--SPRSSLSSPT--SPSSNNALSGS
SDIAPPLPPKSLFVQS-----QMEKANIQSLPLSPTVVVQKRRQGR--GGGKNWKLNPPPVPPARSPT------------
-TELSSK------------------------------------------------------------SHSQSYRLNNVFL
HTVDDFESKFTFHSVEEFPPPDEFKPCLKI----------YPS-------------------------------------
---------
>Stickleback_WIPF3
CPACPPPTQRPTLLESLR-----------LLDTAVRP----------SLSKASQAQRNALLADIQKGARLKKVTQVNDRS
APSVDTVKANTGDVPSSGA----------------ASQGSSGGPAPMGPSLGGLFA--AGFPTLRPTGQRDLAGKTT?--
------PRVS---SSTAR-KAAS-----------------QGARTPSSGTPAAPPRLHGLPST--------------AAR
TAP-FPLLS-----------PTAPPRPLRSSPAPPPRLPGTSGR---QAPP-----------------------------
-----------------------------------LPSCPPPPPPYQVTKPTCSPSS-----------------------
--PSTPPPPPPPPFQPPKAEAGDRKSGCFYPL--------------------PPSP------------------VHSE--
--PSRFSILRDSPLGPPPPPPAPPLP-------------------------ASFGPSCPSTLPPPPPKLAAVPSPAM---
RSLPPSYPCNAPTRRPP---AVPRSAGMSPHPWSDTPLTPVMSSP---MATGVGRLPPPPAPPARSPS------------
-TELSCRTP----------------------------------------------------PPPPPPPLLPLSLRNGHLH
SLADNFESKFQFHPVEDFPPPDEFKPFPRI----------YPSKENRGSSMSQVRLNPPLPPTTT---------------
---------
>Tetraodon_WIPF3
LPVPEPGPAWKTTPPPLA-----------PAPPPPPPPTAVTRHSTFSLFFTFISHRNALLADIQKGAKLRKVTQVNDRS
APVVESR-------TSSPA----------------ASQGSSGGLAPIGPSLGGLFA--GGFPTLKPIGQRDSAGKSSG--
------AADT---RNVPEPPSKT-----------------VEVRNAINRQPSSTASAPASPSQ--------------SSR
HPPPFPATC-----------PPPPPAVPPSALPPPPPPPLPQDRPVSKPPP-----------------------------
-----------------------------------LPSCPPPLPPSQAAKPTWLPAQHSHHTAVSQP-------------
--PTPPPPPPPPPYQTPSHVPGDRSSGCFYPP--------------------PPPH------------------IHTE--
--PARS--FRESALGTPPPPPPPPL------------------------------------LLPPPPKLAPVPSPSP---
ACAASLIPLQCSNQTTP---FCPQKCRNISIPY--TSLTPVYSLP---MVTGAGRLAPPPAPPARSPT------------
-TELSSRT---------------------------------------------------------------ASLRNGHLH
SLDD-FESKFQFHPVEDLPPPDEFKPFPRI----------YPSKENRGT----------FP-------------------
---------
>Hydra_WIPF1
--MPPPPPPPPP------------------SAPPPPKVNTDGGVKKTGGGGDAGAGRGMLLSSIQTGAKLKKT-VTNDRS
SPQIGKVNNGPSGGNELSHGV--------------------KEAGSCGPPMSGMFA--GGMPKLRPAADKGKPGGGGGAA
ILPPNKRSPPQN-NESNQPPNSYPSP-----------INPTSSSGNLAGQRLPTPQTNSKPPP---------------PP
SRELSYDQQRV------GVASLQNDSVSLPISNKPPQLPSNQNRSGALPT------------------------------
-----------------------------------------------------QTNVRGPPPISVNP-------------
----------PPPPPNRSSGPPNSSRTAPPPP------------------------------------------------
------PSRDSLNTRNLPPPPPNRMG----------------------------------------------------GN
PSQNDSLRRVASSSSIGGIEINVSSSFSNQPPPPPVHRTSVTTAPPRQRSATTDDIQPPPPPPPRGSG------------
--------------------------------------------------------------------MRQSMVFPPPPS
PLDSNYEARFQFS--NDFPDPDQFRNIQKT----------YPSKAAKNNEKKQNQFNIPNRSAPPPPPSGRNAPLPPPPP
PPNRR----
>Caenorhabditiselegans_WIPF1
--MPPPPPPPP---------------------PPPPPPPPAASAPPPS-----SNARNALLGDIHKGLKLKKT-VTNDRS
APSVGKVVGSSGSSSNGNS---------------GNGNGPAAKPPQMSGGLGGLFA--NGMPMKPSENKIRRATTSIG--
------PPPTAS-SAPPVPPPAPVP----------------AVEGKKPSIVSSSSFSHHGATS-----------------
-------------------------------SAPPPPPPPP---------------------------------------
-----------------------------------------------------PVSVPSSKPTPPPP-------------
------PPAQQKPSFQSDREQFRTMRPLRPAN-------------------------------------DVKPTMYRRSG
----SSEDIPQATSATRLARPLAPPP--------------------------------ARPAAPPPPVPTPSIAQMSSRF
QSPAISRTLDDAPPPPPRIASKTSVAPTSSRAPLPPSSSFAPSIS---ASPAPAP---PPPPPQAASP------------
--------------------------------------------------------------------YPGMKSTATVSA
NVPFHPLNRFHFLPLSQLPPPPKVSSGSIRA-------------------------------------------------
---------
>Seaurchin_WIPF1
---MPPPPPPPG--------------------PPPPPTFKQANTTPPNLNKNEQKNRGALLGDIHKGMKLKKTVTVDK-S
GPLLECVK---------------------------------------------FLK--CLVLQRRPVNVTSVSQNKFG--
------NGGK---PSGGGLPASRPL---------------PHPSGNS---RPLPSQPQNTHN----------------PV
SARISNK--------------GSSNGHGAADRAPPPPPPSSNRPRPPSTS------------------------------
--------------------------------------FPPPPPSS-------LPSSKPSNNFPPPP--PTS--------
-SIPSRNSRAPPPP---KRDPPSK--GSTPPP--------------------PPPQGRIDN-K-----LSNGPS---TGP
-----PPPPPSRQPPGGRPPPPPRDT-------------------------------PRPGTAPPPP----PPSRSQGRP
PSTVS---SSSSRAPPPPPN---RTSTGHSAPPPPS---RDKGPRP--PSIVGGP---PPPPPSRGTP------------
-RSPPARNPP---------------------------------------------------------ARDSG------IM
NGTDDFESRFRFNSSSRFPTPPPMKKLQKT----------YPSKQ---PNRQ-----STKRGQPPAPPRQ----------
---------
>Anophelesgambiae_WIPF1
----MPPPPPPG--------------------PPPPPGPPPPPALKLGGGAPSADGRNALLLSIQKGAKLKKTVTVDKSA
PAIQGKVTSDGGATRANNRAP------GRPTGDDGAPAAAGPTIGGGQPKLGGLFEGLSSMPKLKPVGSRTGAGTGKEAG
WELPGVCRICLIFYTETHVPQRLTY--------------IAHVGVTLLPQETHLRQHLGISRTKR------------PPR
TPRKPINNG----------RLGNGGANLRLNRGPPPQPPTSIQRVRQKGSGLHRTVQCN---------------------
---------------------------------DMTFFPLFPAIRRQFGVKDRTGTALLHSQAPATPN-----------H
LKLAGSKPSSATNGPMSAIHSSAAAAASTSPTINATGGSAPIPNRSALFGGTTTTTVPTTANSS---IAMGNGSVPSVAA
VPVAPKPVPNYGKPNLAPKPPGMQLG-----------------------------GTAADGGSGTRPTVSRHQSMRSPRS
PPVSQTAPAFPANHFGTMRGPPSSAAMFQSSESIVRPVREVTGRPS-APPPKPPTMKPPPPPPVRSVSNTNLTHLPPSLS
LAPSSQDNTGG-------------------------------------------------TSSPATEPTTFGSVNNVSTL
TLADELRAKVSNVNLSVAGSSANSISTGNLSVLGGGSTLTKGGSLKTTAAPPLPPHRTSPAPPPPVPASTLVSNSGEAPV
PPQRISSIR
>Cionasavignyi_WIPF1
----MLG------------------------IPPYYKQFYSQFRKIHSSESIDVYSFGHLLYEMVYGRQLNKS-TIDMLP
VSSPAEIRS-------------------------------------VLESILSVEACKNGLPTLEGLLIHPLFADETVT-
-------------TVGIKPQLKIPS----------------KLKETFRQYKEAMERKLKEEQK-----------------
--------------------------------------------------------------------------------
-------------------------------------------------------VISQTRRLSKVK-------------
-------AHHSSDSERRRRKLEAR--------------------------------------------------------
-------KKSQMKLDIVEESPD----------------------------------------------------------
---------KSGDGMTPTTPASNTSSATTPVTGVPP------------APPMAPSLEPPPAPPMLNGK------------
-----------------------------------------------------------------------------SPT
EAPAPAGRGALLGSIQDFSKSKLRKSVTVD------------------------------KSNPKI--------------
---------
>jellyfish_WIPF3
--MPPPPPPP---------------------GPPPPPSAPSGPVKPP----PSSKNRGALLSDIHKGARLKKT-VTNDRS
APVVANEKKSSSGGN-LSSSS--------------------SSTGGGGG-----FS--GGG--------GGSMGGGG---
------------------------------------------LGGLFAG-------------------------------
-----------------GMPKLR---------------PAGERKAAGAG-------------------------------
---------------------------------------------------------RRPPSGKINP-------------
----------PPPPP-----------------------------------------------------------------
------PAMD---------------------------------------------------------------------K
PS------------------------FTNGP--------------------VSNNIMDS---------------------
--------------------------------------------------------------------------------
--KNSFECRFNFRTLNELPPPEPYQDTPKT----------YPSKNQQKANRGNPRPASSSRGAPPPVPPSR----GPPPP
PPRQ-----
>Drosophila_WIPF3
MAIPPPPGPP----------------------PPPGPPPPPAMGGLKLGGAGGADARSALLSSIQKGTKLKKTTTVDKSG
PALSGKVCGGDGGAGIGAKR---TLNNNTSTSNHNNSSSSSNGLGNGTPKLGGLFEGLSQMPKLKPVNGIRATPSAGSAA
TTTSKSTTNSSAQQRSNSPPAATSASNASNGPMDFNTELTKHLTLKRQKQQQQQQPQPPTNNTHINATEANLRTNRGPPP
QPPKSANSNDSILERMNIPRTAPTPPFGNSSSVKAASPTLSDSGSNSSGSGGGSGSVKSKAANLNISLGNSFVNSSKSTV
SASTASLNSSLTSSTGSVRNLAPNKSTLFGGSSGSSSGSSSGGGYASVHKSSPPSTADSTPSVTPTPPPLQLP----MKP
AISFGKPNFAPKPPGLNQLAMANGQQRPAVTRHHSMKSPRSPPAAGIVNGLVFPTQQHLGTLRGPLQFHGSESSSPNTSA
GSMRCAPNPPKSRPSVKPPPPPTPARSFSNTNLNNIGGSTMFSAVNTALIQSSAISSQAPSPPITQPPSSSSSSNSVAAL
RDQFRGGAGMSNGAPSPPLPPTPAPSSNPSSASASPKSLLRDNVKP--IILNGGPLNPPAPPPHRSCPPPPPPQRQSSNG
GSGSGSAPVP--------------------------------------------------------PQRHSSIRPNAPST
PPTHMANASHQFGSSSGLSSGSGAGAAASVGRLVNDLETKFGKRFHNVTEFPKPPPFLNIQKVYPSRTFKATNGM-----
---------