>Homo_sapiens_KCNQ4
--------------------------------------------------------------------------------
------------------------------------------------------MAEAPPRRLGLGPPPG----DAPRAE
LVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACG-QRSSAAHKRYRRLQNWVYNVLERPRGWAFVY
H-VFI---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L
LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDMSRAYLTAT
WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTS----FCPGE--
-------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPT------------------------
--MPTSPSSEQ---------------------------------------------------------VGEATSPTKVQK
SWS--FNDRTRFRASLRLKPRTSAE---------------------DAPSEEVAE-----------------EKSYQCEL
TVDDIMPAVKTVIRSIRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR--------------
----------------------VDQIVGRGPGDR---KA-----------------------------------REKGDK
GPS--------------------DA-EVVDEISMMG----------------------------------RVVKVEK-QV
QSIEHKLDL--LLGFYSRCLRSG--TSASLGAVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR-----------
----------SVSTNMD---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Pan_troglodytes_KCNQ4
--------------------------------------------------------------------------------
------------------------------------------------------MAEAPPRRLGLGPPPG----DAPRAE
LVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACG-QRSSAAHKRYRRLQNWVYNVLERPRGWAFVY
H-VFI---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L
LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDMSRAYLTAT
WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTS----FCPGE--
-------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPT------------------------
--MPTSPSSEQ---------------------------------------------------------VGEATSPTKVQK
SWS--FNDRTRFRASLRLKPRTSAE---------------------DAPSEEVAE-----------------EKSYQCEL
TVDDIMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR--------------
----------------------VDQIVGRGPGDR---KA-----------------------------------REKGDK
GPS--------------------DA-EVVDEISMMG----------------------------------RVVKVEK-QV
QSIEHKLDL--LLGFYSRCLRSG--TSASLGAVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR-----------
----------SVSTNMD---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Gorilla_gorilla_KCNQ4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L
LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVI----------
----------GNEX-----EELRKKSELGLRE-------------------------MGDLYPFP-VWKSPTSPRQAQRS
ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDMSRAYLTAT
WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTS----FCPGE--
-------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPT------------------------
--MPTSPSSEQ---------------------------------------------------------VGEATSPTKVQK
SWS--FNDRTRFRASLRLKPRTSAE---------------------DAPSEEVAE-----------------EKSYQCEL
TVDDVMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR--------------
----------------------VDQIVGRGPGDR---KA-----------------------------------REKGDK
GPS--------------------DA-EVVDEISMMG----------------------------------RVVKVEK-QV
QSIEHKLDL--LLGFYSRCLRSG--TSASLGAVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR-----------
----------SVSTNMD---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Mus_musculus_KCNQ4
--------------------------------------------------------------------------------
------------------------------------------------------MAEAPPRRLGLGPPPG----DAPRAE
LVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGGQRSSAAQKRYRRLQNWVYNVLERPRGWAFVY
H-VFI---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L
LILEFVMIVVFGLEYIIR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDTSRAYLTAT
WYYYDSILPSFR---------ELALLFEHIQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSAS----FCPGE--
-------------------------SSRMGIKDRIRISSSQK-RTGPSKQHLAPPP------------------------
--IPTSPSSEQ---------------------------------------------------------VGEASSPSKVQK
SWS--FNDRTRFRASLRLKPRCSAE---------------------EGPSEEVAE-----------------EKSYQCEL
TVDDVMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQAR--------------
----------------------VDQIVGRGPGDR---KT-----------------------------------REKGDK
GPS--------------------DT-EAVDEISMMG----------------------------------RVVKVEK-QV
QSIEHKLDL--LLGFYSRCLRSG--TSASLGTVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR-----------
----------SVSTNMD---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Dasypus_novemcinctus_KCNQ4
--------------------------------------------------------------------------------
------------------------------------------------------MAEAPPRRLGLAPPPG----DAPRAE
LVALTAVQSEQGEAGGGGSPRRHGLLGSPLPPGAPLPGPGSGSGSACG-QRSSAAHKRYRRLQNWVYNVLERPRGWAFVY
H-VFI---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVLSTIQ---EHQELANEC----------------------------------------------L
LILEFVMIVVFGLEYIVR-----------------VWSAGCCCRY-RGWQGRFRFARKPF-------CVIDFIVFVASVA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NSDFSSYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDTSRAYLTAT
WYYYDSILPSFR---------ELALLFEHVQRARNGGLRPLEVRRVPVPDGAPSRYPPVATCHRPGSTS----FCPGE--
-------------------------SSRMGIKDRIRMGSSQR-RTGPSKQHLAPPP------------------------
--IPTSPSSEQ---------------------------------------------------------MGEATSPTKVQK
SWS--FNDRTRFRASLRLKPRTSAE---------------------EGPSEDVAE-----------------EKSYQCEL
TVDDVMPAVKTVIRSVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQAR--------------
----------------------VDQIVGRGTGDR---KA-----------------------------------REKGDK
GPS--------------------DP-EAVDEISMMG----------------------------------RVVKVEK-QV
QSIEHKLDL--LLGFYSRCLRSG--TSASLGTVQVPLFDPDITSDYHSPVDHEDIS---VSAQTLSISR-----------
----------SVSTNMD---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Xenopus_tropicalis_KCNQ4
--------------------------------------------------------------------------------
--------------------------------------------------MAVGTQPQADNGRVPSLSLAPISGQESGME
FVALTAVQTDSGNPR---------RLGLLGTPIPGAP-------------RSSSSHKKYRRLQNYLYNVLERPRGWAFIY
H-AFI---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FFLVFSCLVLSVFSTIP---EYHHLANKG----------------------------------------------L
FILEFVMIVVFGMEYVIR-----------------IWSAGCCCRY-RGWKGRLRFARKPF-------CVIDFIVLVASLA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDA----------------NKEFSTYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRT---PAANLIQA-AWRLYSTDVSRSYLTAT
WYYYDSILPSFR---------ELLLLFDTWHRTCS---RNGGVRLCQG--SPRYQPVPSTPKP----ATPP--FCTGE--
-------------------------SSKLGLKDRMRGTVAPK-QTTRSKQYLAPP-------------------------
--ERASPGTEP---------------------------------------------------------AAETPSPTKVQK
SWS--FNDRTRFRASLRLKSRPQAD---------------------EGPGDDIND-----------------EKRLPNDL
TMEDVMPTIKTLIRAFRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQGR--------------
----------------------VDQIIGRGPVPVEKKP------------------------------------RDKGEK
VSTMG------------------PEVEAADELSMMG----------------------------------RVVKVER-QV
QSIEDKLDI--LLGFYSQCIRKGPASSFTLTSMQMPLIDQEMTSDYQSPVDPVDFS---VSAQTLNISH-----------
----------SASTNME---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Takifugu_rubripes_KCNQ4_a
--------------------------------------------------------------------------------
------------------------------------------------------MLGSPSNNGGIRMLAPPAPDDDRRVE
FVALTAVHTERSEPSTPERGHPSHRTGLLGTPLPGPPGP---------RANTSASSKRFRKLQNFLYNVLERPRGFAFIY
H-AFN---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVFSTIH---EHQKFANQDSS------------------------------------------SWW
LLHEFVMIVVFGLEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDLIVFVPSLA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFFVYLVEKDV----------------NTDFNTYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDASHSYLTAT
WYFYDSMLPSFR---------ELTLLFSHLQRQRNKQLLPLHDTYAQIHAGRKQRYPRLRACARGSADCFV--PSRGE--
-------------------------GSKIGFRDRIRMNNSRSSQTIRSKASPLPPGSN----------------------
--VRRSPSQEN---------------------------------------------------------VPDPTSPGKVQK
SWS--FNDRTRFRTSLRLKPRPPADV--------------------EGVGEDSTE-----------------DKP-YCDM
AMEEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR--------------
----------------------VDQIIGRGAVQPDKKAR-----------------------------------PEKGEK
TP---------------------PELDSLDELSMMG----------------------------------RVVKVEK-QV
QSIENKLDL--LLNLYSHCLKKGSSN-YTLSTL----LDPDLTSDYHSPTDQRDLF---PSANTLNIST-----------
----------SESGNLE---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Tetraodon_nigroviridis_KCNQ4_a
--------------------------------------------------------------------------------
------------------------------------------------------MLGSPSNNGGIRMLAPPAPDDERRVE
FVALTAVHTERSEPSTPERGHPSHRTGLLGTPLPGPPGP---------RASASASSKRFRKLQNFLYNVLERPRGFAFIY
H-AFI---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVFSTIP---EHQKFANQG----------------------------------------------L
FILEFVMIVVFGLEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDLIVFVASLA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDI----------------NTDFSTYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDASHSYLTAT
WYFYDSMLPSFR---------ELTLLFSHLQRRTPGALWSIETSHLTPPPCSQERVPDLKPCP---PRFHS--FFFAV--
-------------------------SSKIGFRDRIRMNNSRSSQTIRSKASPLPPGSN----------------------
--GRRSPSQEN---------------------------------------------------------MADSTSPGKVQK
SWS--FNDRTRFRTSLRLKPRPPADA--------------------EGVGEDSVE-----------------DKP-YCDV
AMEEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTR--------------
----------------------VDQIIGRGAVQPDKKVR-----------------------------------PEKGEK
TP---------------------PELDSLDELSMMG----------------------------------RVVKVEKQQV
QSIENKLDL--LLDLYSHCLKKGSSN-FTLSTL----LDPDLTSDYHSPTDQRDLF---PSANTLNIST-----------
----------SESGNLE---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Gasterosteus_aculeatus_KCNQ4_a
--------------------------------------------------------------------------------
------------------------------------------------------MPESPSNNGGARMLAPPTSSDDRRVE
FVALTAVHTERSEPSSPERGHPSNRTGLLGTPHTSASNK---------RYRKLQN---------CLYNVLERPRGWAFIY
H-AFI---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVFSTIP---DHQRFANQG----------------------------------------------L
FILEFVMIVVFGLEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDFIVFVASLA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDI----------------NSDFNTYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFCPCLLTPQG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDAKHSYLTAT
WYFYDSMLPSFSARGGVR---ELTLLFSHLQRQRNTKKVLPSSYHTLLSGLRPYSLPYLS----------------GD--
-------------------------SSKMGFRDRIRMNNSRSSQTIRSKGSPLPPSSG----------------------
--VRGSPSQEN---------------------------------------------------------VPEAISPGKVQK
SWS--FNDRTRFRTSLRLKTRPPVDGS------------------VEGVGEDSVE-----------------DKP-YCDV
SMEEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQMR--------------
----------------------VDQIIGRGAVQPDKKAR-----------------------------------TEKGEK
TP---------------------PELDPLDELSMMG----------------------------------RVVKVEK-QV
QSIENKLDL--LLSFYSQCLKKGSSH-FTLSSL----LDPELTSDYHSPTDQRDLF---PSANTLNIS------------
-----------ESGNLE---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Oryzias_latipes_KCNQ4_a
--------------------------------------------------------------------------------
----------------------------------------------------------------------PGPNDDRRVE
FVALTAVQTERSEPSTPERGPPSHRTGLLGTPLPGPPGP---------RASASASSKRFRKLQNFLYNVLERPRGWAFIY
H-AFM---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----WEVRMSSVLF------------------L----------------------------------------------C
ALQEFVMIVVFGMEYFIR-----------------IWAAGCCCRY-RGWQGRLRFARKPF-------CVIDFIVFVASLA
VI------AAGTQGNIFATSALRSMRFLQILR-------------------------MVRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----VLIFASFLVYLAEKDI----------------NSDFGTYADSLWWGT------------------
-------------------------------ITLTTIGYGDKTPRTWQGRLLAAGFALLGVSFFA----LPAG--ILGS-
-------------------------------GFALKVQEQHRQKHFEKRRM---PAANLIQA-AWRLYSTDAKHSYLTAT
WYFYDSMLPSF------R---ELTLLFSHLQRQRSTKKVLQNSYHTLLSGLRPNSSPYLS----------------GD--
-------------------------SSKMGFRDRIRMNNSRSSQAIRNKASPLPPGSG----------------------
--VRRSPSQEN---------------------------------------------------------IPEATSPGKVQK
SWS--FNDRTRFRTSLRLKPRPPVDA--------------------EGLGEDSVE-----------------DKP-YCDV
AMDEVIPAVKTLIRAVRILKFLVA-----KRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQMR--------------
----------------------VDLIIGRGPVQPDKKTR-----------------------------------PEKGEK
TP---------------------PDLDPLDELSMMG----------------------------------RVVKVEK-QV
QSIEGKLDL--LLSFYSQCIKKGSSH-VTLSSL----LDPDLTSDYHSPTDHRDLF---PSANTLNISR-----------
----------SESDNLE---------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Apis_mellifera_KCNQ4
--------------------------------------------------------------------------------
---------------MKDRPHRPYRDHHGQAMPLEEVQGLLLPPSRTGNRGPLTIVQVGKGNGGGGDGGSDLLKLEPPSD
LRPTPSPLSETSATLQSDNNDTFSGGVDPRLLLGANTGGDRNTWEGRYRVKEHRRAGKATFQGQVYNFLE-RPTGWKCFL
YHFSV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FMVVLVCLIFSVLSTIE---QYSNFANET----------------------------------------------L
FWMEICLVVFFGVEYLVR-----------------LWSAGCRSKY-MGCCGRLRFIRKPI-------CIIDLIVVVASMV
VL------SVGSNGQVFATSAIRGIRFLQILR-------------------------MLHVDRQGGTWRLLGSVVFIHRQ
ELITTLYIGFL----GLIFSSYFVYLAEKDV----IGPDG-------KTDFSSYADALWWGV------------------
-------------------------------ITVTTIGYGDTVPQTWMGKIVASCFSVFAISFFA----LPA--GILGS-
-------------------------------GFALKVQQKQRQKHFNRQIP---AAAMLIQC-LWRCYAADK-AINSVAT
WNIYIKDPAP--------------------------------AGQPSTPLGKLI--------------------------
--------------------CVKKMSLMIQVAKK-ASVLKRRKSRNRMDVQQQQQ-------------------------
--QSLPPVTIS--------------GGMSSGGATGDQN---------------------------DNQRMENEGDVIFYM
EEPK-AGTPNRARRDNRGS------LFTS-----------QTSSVTEATSDEIDIDI--------------E-----EPQ
RVTTLTEAHRNAIRAIRKIKYFVA-----RRKFQQARKPYDVRDVIEQYSQGHLNMMVRIKELQRR--------------
----------------------LDQTLGKPGSY-----------------------------------------LAGIDR
AGNV--------------------------KPMTIGAR---------------------------------LYRVEQ-QL
SVMDKKLDQ--LVYVLNAVAQKQQ---------IPLRSIEDDV-------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Homo_sapiens_KCNQ3
--------------------------------------------------------------------------------
-----------------------MGLKARRAAGAA-GGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLA
LGAGADKDGTLLLEGGGRDE----------GQRRTPQGIGLLAKTPLS-RPVKRNNAKYRRIQTLIYDALERPRGWALLY
-HALV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L
LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT
WRFYESVVSFPFFRKEQ-------------------------LEAASSQKLGL---------------------------
-------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPMAE-----------------DRGYGNDF
PIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR--------------
----------------------IDMIFTPGPPSTPKHKKSQKGS----------------------------AFTFPSQQ
SPRN------------EPYVAR-PSTSEIEDQSMMG----------------------------------KFVKVER-QV
QDMGKKLDF--LVDMHMQHMERLQVQVTEYYPTK---GTSSPAEAEKK-EDNRYSDL-----KT----------------
-------IICNYSETGPPEPPYS-FHQVTIDKVSPYGFFAHDPVN-------LPRGGPSSGKVQATPPSSATTYVERPTV
LPILTLLDSRVSCHSQ---------ADLQGPYSDRISPRQRR--------------------------------------
---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------VFGPNGGS
SWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSVWTPSNKPI-----------------------------
--------
>Macaca_mulatta_KCNQ3
--------------------------------------------------------------------------------
-----------------------------------------------------XGDAAAAGDEERKVGLAPGDVEQVTLA
LGAGADKDGTLLLEGGGRDE----------GQRRTPQGIGLLAKTPLT-RPVKRNNAKYRRIQTLIYDALERPRGWALLY
-HALV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L
LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT
WRFYESVVSFPFFR--Q-------------------------LEAASSQKLGL---------------------------
-------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPTAE-----------------DRGYGNDF
PIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR--------------
----------------------IDMIFTPGPPSTPKHKKSQKGS----------------------------AFTFPSQQ
SPRN------------EPYVAR-PSTSEIEDQSMMG----------------------------------KFVKVER-QV
QDMGKKLDF--LVDMHMQHMERLQVQVTEYYPTK---GTSSPAEAEKK-EDNRYSDL-----KT----------------
-------IICNYSETGPPEPPYS-FHQVPIDKVSPYGFFAHDPVN-------LPRGGPSTGKVQAAPPSSATTYAERPTV
LPILTLLDSRVSCHSQ---------ADLQGPYSDRISPQQRR--------------------------------------
---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------VFGPNGGS
SWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSVWTPSNKPI-----------------------------
--------
>Mus_musculus_KCNQ3
--------------------------------------------------------------------------------
-----------------------MGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLA
LGAGADKDGTLLLEGGGREE----------GQRRTPQGIGLLAKTPLS-RPVKRNNAKYRRIQTLIYDALERPRGWALLY
-HALV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L
LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVPEMDAQGE------EMKEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRLDLVAT
WRFYESVVSFPFFRKEQ-------------------------LEAAASQKLGL---------------------------
-------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPMAE-----------------DRGYGNDF
LIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR--------------
----------------------IDMIFTPGPPSTPKHKKSQKGS----------------------------AFTYPSQQ
SPRN------------EPYVAR-AATSETEDQSMMG----------------------------------KFVKVER-QV
HDMGKKLDF--LVDMHMQHMERLQVHVTEYYPTK---GASSPAEGEKK-EDNRYSDL-----KT----------------
-------IICNYSETGPPDPPYS-FHQVPIDRVGPYGFFAHDPVK-------LTRGGPSSTKAQANLPSSGSTYAERPTV
LPILTLLDSCVSYHSQ---------TELQGPYSDHISPRQRR--------------------------------------
---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------VFGPSGGS
SWMREK-RYLAEGETDTDTDPFTPSG-SMPMSSTGDG-ISDSIWTPSNKPT-----------------------------
--------
>Bos_taurus_KCNQ3
--------------------------------------------------------------------------------
-----------------------MGLKARRPAGAAGGGG-DGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLA
LGAGADKDGTLLLEGGGRDE----------GQRRTPQGIGLLAKTPLS-RPVKRNNAKYRRIQTLIYDALERPRGWALLY
-HALV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFR---EYETVSGDW----------------------------------------------L
LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT
WRFYESVVSFPFFRKEQ-------------------------LDPAASQKLGL---------------------------
-------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
PV-G-SNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPTAE-----------------DRGYGNDF
LIEDMIPTLKAAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR--------------
----------------------IDMIFTPGPPSTPKHKKSQRGA----------------------------AFTYPSQQ
SPRN------------EPYVAR-PSTSETEDQSMMG----------------------------------KFVKVER-QV
HDMGKKLDF--LVDMHLQHMERLQVHVAGFSPSK---GASSPAEAEQK-EDRRDADL-----KT----------------
-------IICNYSETGAPDAPYS-FHQVPVDKVGPYGFFAHDPVN-------LPLGGPSSGKGHA------TPYAERPTV
LPILTLLDSRGSYRSQ---------VELHGPCSDRVSPRQRR--------------------------------------
---------------------SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDY---------------AFGPSGGS
SWMREK-RYLAEGETDTDTEPFTPSG-SLPLSSTGDG-ISDSIWTPSGKPT-----------------------------
--------
>Myotis_lucifugus_KCNQ3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------------------QTPSS
-FPPR---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L
LLLETFAIFVFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVPEVDAQGE------EMKEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT
WRFYESVVSFPFFRKEQ-------------------------LEAAASQKLGL---------------------------
-------------------------------LDRVRLSNP---RGSNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
PV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGDPMAE-----------------DRDYGNDF
-IEDMIPTLKAVIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR--------------
----------------------IDMIFTPGPPSTPKHKKSQKGA----------------------------AFTYPSQQ
SPRN------------EPYLAR-ASTSEMEDQSMMG----------------------------------KFVKVER-QV
QDMGRKLDF--LVDMHMQHMERLQAHVPYYDPAK----GTSPAAEEER-GDPRDSEM-----KT----------------
-------ILCNYSETGLPDPSFS-FHQVPIDKVSPYRFFAHDPVG-------LPRGGPGSGRVPGTLSSSTPAYMERPTV
LPILTLLPSP----------------------TDPHGLRQRR--------------------------------------
---------------------SFTRDSDTPLSLMSVDHEELERSPSGFSISQDRDD----------------VFGLGGGS
SWMREK-RYLAEGETDTDTDPFTPSS-SMPLSSTGDG-ISDSIWTPSNKPV-----------------------------
--------
>Monodelphis_domestica_KCNQ3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L
LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVPEIDAQGV------EMKEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT
WRFYESIVSFPYFRQQL--------------------------EAAASQKLGL---------------------------
-------------------------------LDRVRLSNP---RGTNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
NV-G-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGEPMAE-----------------ERGYSNEF
LIEDMIPTLKSAIRAVRPAVFALF-----CT-------------VTGLASTKYSEILFSYFFRSFR--------------
----------------------VDMIFTPGPPSTPKHKKSQRGG----------------------------AFTYPSQQ
SPRN------------DPYVAK-ASSSEIEDQSMMG----------------------------------KFVKVER-QV
HDMGKKLDF--LVDMHMQHMEQLQVQVTEYYPTKK--ATATPAEAEKK-EENKYSEL-----KT----------------
-------IIYNYSEPCTQESPYS-FHQVPVNKVSPYAFFAHDPEK-------LPRTVPSS-----------VPYAERPTV
LPILTLLDSRVSYHSQ---------AELHSPYQDRISPRQRR--------------------------------------
---------------------SFTRDSDTPLSLLSVNHEELERSPSGFSISQDRDDY---------------LFGPNGGS
SWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSIWTPSNKPV-----------------------------
--------
>Gallus_gallus_KCNQ3
--------------------------------------------------------------------------------
------------------------------------------MGLKARRGAAGGSGAGGAAEGRRAAGGGGGDPEQGSLA
LGSGADRDGTLLLEGGGKEE----------GGKRSPPGLGLLAKTPLS-RPVKRNHAKYRRIQTLIYDALERPRGWALLY
-HGFV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---EYETVSGDW----------------------------------------------L
LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVPEKDANGV------EMKEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRIDLVAT
WRFYESIVSFPFFR-KEQ------------------------LDGTASQKLGL---------------------------
-------------------------------LDRVR--------GTNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
NV-V-LNNKERFRTAFRMKAYAFWQSSED-----------------AGTGEPGGE-----------------ERGDSSDF
LMEDMIPTFKTAIRAVRILQFRLY-----KKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQAR--------------
----------------------VDMIFTPGPPSTPKHKKSQKGG----------------------------AFSYPSQQ
SPRN------------DPYVAK-ASTVDTEDQSMMG----------------------------------KFVKVER-QV
NDMGKKLDF--LVDMHMHHMEQLQIQVAEISPLK---ETASPAKEKR--EENKYSEL-----KT----------------
-------IIYKYTDQCTHETPYN-FQQVPVNKVSPYGFSAHGHMTHSQP---LSTGGQNSGKLQATPSS--ASYAERPTV
LPIFTLMDSQVSYHSQ---------GDMQSPYSDKVSPRQRR--------------------------------------
---------------------SLTRDSDTPLSLLSVNHEELERSPSGFSISQDRDDF---------------PFGPNGGC
AWMREK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-ISDSIWTPSNKPV-----------------------------
--------
>Anolis_carolinensis_KCNQ3
--------------------------------------------------------------------------------
-----------------------MGLKARKAAAAGAKAAPSSSLAAPPPRPRGPGAEPGEGPKGADLEQGGGG-------
-GAGADKDGTLLLGRPTREEEDDDEEEGLPQRRSAGQGLGLLAKTPLSRHPVKRHNLKYRRSQTLIYDALERPRGWALLY
-HAFV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---DYEKASEKW----------------------------------------------L
LLLETFAIFIFGAEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIFVLIASVP
VV------AVGNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAICAHSK
ELITAWYIGFL----TLILSSFLVYLVEKDVAETNEQGQ------ETR-DFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLVGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-AAWRYYATNPNRLDLVAT
WRFYESVVSFPYFRKEQ--------------------------VDGTSQKLGL---------------------------
-------------------------------LDRVR--------GTNTKGKLFTPLNV----------------------
-------DAIE-------------------------------------------------------------ESPSKEPK
SVVV-LNNRERFRTAFRMKAYAFWQSSED-----------------AGTGDPLAE-----------------DRGYSNEL
ITEDMIPTLKAVIRAVRILQFRLY-----KKRFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR--------------
----------------------IDMIFAPGPPSTPKHKKSQKGG----------------------------TFSYPSQQ
SPRN------------EPYIAK-ASTVDSEDQSMMG----------------------------------KFVRVER-QV
HDMGKKLDF--LVDMHMQHMEQLQVQVTEVCPSK---EASSPA------EDNRYSEL-----KS----------------
-------IIYKYSEPSIHEKPPS-FHHVPVNKVPPFGFTTQGQSCGPFP---SPFGGQNSSRWPAMPFS--TSYAERPTV
LPILTFIDPHISYQSPP--------GDFQSPHSERIPSRQKH--------------------------------------
---------------------SVTRDSDTPLSLLSVNHEELERSPSGFSISQDRDDF---------------LFGPNGGS
SWMKEK-RYLAEGETDTDTDPFTPSG-SMPLSSTGDG-LSDSIWTPSSKPV-----------------------------
--------
>Xenopus_tropicalis_KCNQ3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------------------WAANW
-ATLM---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAILTTFK---EYEDASGDW----------------------------------------------L
LLLETFALVIFGVEFALR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCMLDIYIYIPAFS
LL------TIGHNNQICCR-LVNSLQWVASHL-------------------------KGTMSYS--TWENLNLHYMAANR
ELITAWYIGFL----TLILSSFLVYLVEKDVPERNEKGE------LVEEEFETYADALWWGL------------------
-------------------------------ITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRK---PAAELIQ-SAWRFYATNLSRIDLIAT
WRYYETTVQFPYFRLRKE-----------------------QMDGTNRLVIHFG--------------------------
-------------------------------LFVERIGSE---KGLYGKYILFLPLGV----------------------
-------TVAA-------------------------------------------------------------PMNSKGDR
GP-G-LHHCNKFHNDFQAKIQSLWSKNDA-----------------GAAGEPIAE-----------------S-GYGAEA
MLEDLIPTIKAAIHASRILQFLLH-----KKRFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTR--------------
----------------------IDMVFAPGPLSTPKHKKSQKGTGGLGG-----------------------GFGYSSQQ
SPRH------------DPYSVK---VPEIEDQSMMG----------------------------------KFVKVER-QV
QDMEKKLDF--LVDMHMQHMDQLQVHITEYYPLR-----ETLAEDEGV--DSRYSEV-----EG----------------
-------LIYNYTESCAHTSPYHHLHQVSFNKTNQYGFFENYPRNFSAP---LPFNGENCPRVATPPSS---SYTERPTV
LPIQTLIDTRVEFQDS---------GGASNPYLKEASPTQRR--------------------------------------
----------------------SFRDSDTPLSLLSVNHDELQRSPSGFSISQEKEDF---------------SFGNN-GS
NWMREK-RFLAEGETDTDTDPFTPSG-PITLSSTGDG-ISESAWTPS-KPV-----------------------------
--------
>Tetraodon_nigroviridis_KCNQ3_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------GFSLVF
-HVFR---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAVLTTFK---EHEKVSAHW----------------------------------------------L
VILETFAIFIFGAEFALR-----------------IWAAGCRCRY-KGWRGRLQFARKAA------LRAGDIFVLIASVP
VV------AVRNQGNVLAT--LRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAIYAHSK
ELITAWYIGFL----SLILASFLVYLVEKDDVSVDASDPESPTAQPRTQDFDTYADALWWG-------------------
------------------------------------AGRSDG-PHSCEQRTVG---ALVG--------------------
----------------------------------------------DRRNL---PHAD--G-SSWN--QTN---------
-NLSGLIRNLLCCPS--------------------------------SQKLRL---------------------------
-------------------------------LERVRLPNA---P----------TGSS----------------------
-------DGAE-------------------------------------------------------------ESPSK---
PA-G-FSNRERLRTAFRMRAYTLRQSSEDP----------------AAPTEAAVE-----------------ERGFPPDI
LLEEMIPTLKLVIRAVRILQFLLN-----KKRFKETLRPYDVKDVIEQYSAGHLDMLCRIKYLQTR--------------
----------------------IDMILAPGPPLTPKQKKSQKPP-----------------------------FACPSSQ
SPRH------------ESFLPKAASLPDAEDQSMMG----------------------------------RFVRVER-QV
EDMEKKLDF--LVDMHIQHTEHLQVDSVGTAHMTL--EACHPTGN---------GEI-----RR----------------
-------VFLNYAEGFP---HMA--YQVPVGGASR------TREGQ----------RLP---------AAVPTYTERPTV
LPISSLQDQAGGVART----------------------------------------------------------------
---------------------TGGRGADTPLSMLSVNHEELERSPSGFSISGERDGED----G---------GGPSAGAT
VRTRARPTHLAEGETDTDTDPFTPSGGPLPLSSTGEG-FGESVWATPP--------------------------------
--------
>Gasterosteus_aculeatus_KCNQ3_a
--------------------------------------------------------------------------------
------------------------------------------------------------ASGSEEQKQTCGAPPGDLDQ
GTGGADRDGALLLAAPGREDFKRGSQGIGIGLLAKTPLN--------YTGPAKRNNNRRRRIQNLLYDALERPRGWALLY
-HAFV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAILTTFR---EHEKVSAHW----------------------------------------------L
VILETFAIFIFGAEFGLR-----------------VWAAGCCCRY-KGWRG-----------------------------
EA------QVR--------------KLLCILG-------------------------KHVSNVG------IGSSLKEHSR
--VNAACRG-----------------------GTQVTEVTEVTVSHLQITLTT---------------------------
------------------------------------IGYGDKTPKTWAGRLLAGTFALIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRH---PAAGLIQ-SAWRYYSTNPIREDLIAT
WRFYETIISLPCFRKDH-------------------------LEAIASQKLSL---------------------------
-------------------------------LERVRLPNA---RPSIGTGKRL-TGHT----------------------
-------DSIE-------------------------------------------------------------ESPSKEPK
PA-G-FSNRERFRTAFRMKAYTLRQSSEDG----------------GALAEPALE-----------------ERGFPPDI
LMEEMIPTLKLVIRAVRIMQFLLN-----KKRFKETLRPYDVKDVIEQYSAGHLDMLCRIKYLQTR--------------
----------------------IDMILAPGPLLTPKQKKTPKAP-----------------------------FNYPANQ
SPRH------------ESYLAKATSIPDVEDLSMMG----------------------------------RFVRVER-QV
EDMEKKLDF--LVDMHIQHSEHLQVDSAGAAHMTL--EACNPTGA---------GEI-----RR----------------
-------VFFNYAESFP---HLS--YQMPVGKMSGGSGG--GGGHQ----------PPPPLLHQRRPPAAVPTYAERPTV
LPISSLQDLSAGPGRT----------------------------------------------------------------
---------------------TGARGGDSPLSMLSV-HDELERS-SGFSISGSR-----------------------MKP
AGRDPDPSYLAEGETDTDTDPFTPSGGALPLSSPGEG-FGDAVWNTPP--------------------------------
--------
>Oryzias_latipes_KCNQ3_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLIVLGCLILAILTTFK---EHENTSAHW----------------------------------------------L
VILETFAIFIFGAEFGLR-----------------IWAAGCCCRY-KGWRGRLKFARKP-------LCILDIFVLIASVP
VV------VVRNQGNVLAT-SLRSLRFLQILR-------------------------MLRMDRRGGTWKLLGSAIYAHSK
ELITAWYIGFL----SLILASFLVYLVEKDDVSVDGSDREDPTVQPKQQDFDTYADALWWGL------------------
-------------------------------ITLTTIGYGDKTPKTWAGRLLAGTFALIGVSFFA----LPA--GILGS-
-------------------------------GLALKVQEQHRQKHFEKRRH---PAAGLIQ-SAWRYYSTNPVRDDLIAT
WRFYETIISLPCFRQDT-------------------------FEVMVSQKLSL---------------------------
-------------------------------LERVRLSNT---RPSVGMGKRL-MGNA----------------------
-------DSVE-------------------------------------------------------------DSPSKESK
PA-G-FSNRERFRTAFRMKAYTLRQSSEDA----------------GALADPALE-----------------ERGFPPDI
LMEDMIPTLKLVIRATRIMQFLLN-----KKRFKETLRPYDVKDVIEQYSAGHLDMLCRIKYLQTR--------------
----------------------IDMILAPGPLLTPKSKKTQKTP-----------------------------FSYPANQ
SPRQ------------ESYLPKTTAMPDTDDQSMMG----------------------------------RFVRVER-QV
EDMEKKLDF--LVDMHIQHTEHLQVDSAGTAHMTL--ETCGPGAN---------GEI-----RR----------------
-------VFLNYSEAFP---HMS--YQVAIGKAGRGRGDQECRRGA----------GLARGHPERPAMGTVPTYIERPTV
LPISSLQDLSAGPGRT----------------------------------------------------------------
---------------------TGRQGGDSPLSMLSVNHEELERSPSGFSISVDREGDERVPTE---------ADMATGEV
SWTRPRPSYLAEGETDTDTDPFTPSGGALPLSSTGEG-FCDAEWNAPL--------------------------------
--------
>Drosophila_melanogaster_KCNQ3
--------------------------------------------------------------------------------
----------------------------------------------MDPDNDIYAFY-----------------------
----------------DIRGYKGKCRPGRPNSERILQPRMSLLGKPLNYNRGTRRDVRYRRLQSRLYNFLERPRGLHAIF
YHVMV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLMVFTCLALSVFSTIKEYEEDA-------------------------------------------------VYIL
FRMEILVVIWFTMEFGAR-----------------LWSSGCRSRY-QGCLGRLKFVKRPF-------CIIDIVTILASIV
VL------GMGTSGQVFATSALRGLRFFQILR-------------------------MVRMDRRGGTWKLLGSVVYAHRQ
ELITTMYIGFL----GLIFASFLVYMWEKDVN----------------DKFSNFAQALWWGV------------------
-------------------------------ITLCTVGYGDMVPITWQGKLIASCCALLGISFFA----LPAG--ILGS-
-------------------------------GFALKVQQQQRQKHMIRRRQ---PAATLIQA-VWRCYAADE-HSVSVAT
WNIHRVALPSPPAS-----------------------RASSSFKHNTSFVARLP--------------------------
-----------------------------TIRRHKSQ------TIQTPGGGDGGGVSKPPG-------------------
--------------------------------------------------------------------------SSRAST
RYTRTIRDINASVENLEVVQNGKSMNPSFSEDSVAETTCLKNIKNSDDEEDEPR--------------------------
-CTQLTNRHKTAIRFIRKLKYFVA-----RRKFKEALKPYDVKDVMEQYAAGHVDLLGRVKMLHLR--------------
----------------------LDQILGKQ--------------------------------------------GSKAKD
VYAS--------------------------KISLAS----------------------------------RVVKVER-QV
ADIEEKLDI--LIKAYMEDRDRFLALPLPAKPKIHSISPSHKPLHHAHNLAMIDVWKRTAALSVHPEQVTTT--------
-------PLLNPSAPDSSELRSLTATQTPTTTTDAIATQTPMPPHVQHTATNTKSSVLNSYQLGSEKQQHNDVFMTELEN
RTKKRVTLS-LHRSTSEPYSKQEQRITIPDEGADSLDSSAKPTP------------------------------------
-------------------------PDSSIILIDEYEDFEEEDLNCEGEMDHFPTWEIDSDIG-VEVDVDADADGDCDES
TEDTALLQCATRTAIVITPISPVSSAHNLQQLNDQTTTLNKSNLLPPDSG------------------------------
--------
>Homo_sapiens_KCNQ2
--------------------------------------------------------------------------------
--------------------------------------------------------------MVQKSRNGGVYPGPSG-E
KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY
-HAYV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVFSTIK---EYEKSSEGA----------------------------------------------L
YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA
VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK
ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------
-------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS-
-------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST
WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLAFRKD---PPPEPSPS---------------
---------------------------QKVSLKDRVFSSP---RGVAAKGKGSPQAQ---------------------TV
RRSPSADQSLE-------------------------------------------------------------DSPSKVPK
SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIVD----------------D-KSCPCEF
VTEDLTPGLKVSIRAVCVMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQS---------------
---------------------RVDQIVGRGPAITDKDR------------------------------------TKGPAE
AELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV
LSMEKKLDF--LVNIYMQRMGIPPTETEAYFGAK----EPEPAPPYHSPEDSREHVD-----RHGCIV------------
------KIVRSSSSTGQKNFSAPPA--APPVQCPPSTSWQP---------QSHPRQGHGTSPV---GDH-GSLVRIPPPP
AHERSLSAYGGGNRA--------SMEFLRQEDTPGCRPPEGNL-------------------------------------
------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNS-------------CYAAV
APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVGWAGPRK-------------------------------
--------
>Pan_troglodytes_KCNQ2
--------------------------------------------------------------------------------
--------------------------------------------------------------MVQKSRNGGVYPGPSG-E
KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY
-HAYV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFS----------------------------------------------------------------------
-WLEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA
VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK
ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------
-------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS-
-------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST
WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLAFRKD---PPPEPSPSKGSPCRGPLCGCCPG
RS------------------------SQKVSLKDRVFSSP---RGVAAKGKGSPQAQ---------------------TV
RRSPSADQSLE-------------------------------------------------------------DSPSKVPK
SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIVD----------------D-KSCPCEF
VTEDLTPGLKVSIRAV----------------------------------------------------------------
----------------------VDQIVGRGPAITDKDR------------------------------------TKGPAE
AELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV
LSMEKKLDF--LVNIYMQRMGIPPTETEAYFGAK----EPEPAPPYHSPEDSREHVD-----RHGCIV------------
------KIVRSSSSTGQKNFSAPPA--APPVQCPPSTSWQP---------QSHPRQGHGTSPV---GDH-GSLVRIPPPP
AHERSLSAYGGGNRA--------SMEFLRQEDTPGCRPPEGTL-------------------------------------
------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNS-------------CYAAV
APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVGWAGPRK-------------------------------
--------
>Mus_musculus_KCNQ2
--------------------------------------------------------------------------------
--------------------------------------------------------------MVQKSRNGGVYPGTSG-E
KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY
-HAYV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVFSTIK---EYEKSSEGA----------------------------------------------L
YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA
VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK
ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------
-------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS-
-------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST
WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLTFRKE---PQPEPSPS---------------
---------------------------QKVSLKDRVFSSP---RGMAAKGKGSPQAQ---------------------TV
RRSPSADQSLD-------------------------------------------------------------DSPSKVPK
SWS--FGDRSRTRQAFRIKGAASRQNSE----------------EASLPGEDIVE----------------DNKSCNCEF
VTEDLTPGLKVSIRAVCVMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQS---------------
---------------------RVDQIVGRGPTITDKDR------------------------------------TKGPAE
TELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV
LSMEKKLDF--LVSIYTQRMGIPPAETEAYFGAK----EPEPAPPYHSPEDSRDHAD-----KHGCII------------
------KIVRSTSSTGQRNYAAPPA--IPPAQCPPSTSWQ----------QSHQR--HGTSPV---GDH-GSLVRIPPPP
AHERSLSAYGGGNRA--------STEFLRLEGTPACRPSEAAL-------------------------------------
------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALGS-------------CYAAV
APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVAWAGPRK-------------------------------
--------
>Rattus_norvegicus_KCNQ2
--------------------------------------------------------------------------------
--------------------------------------------------------------MVQKSRNGGVYPGTSG-E
KKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTG--GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY
-HAYV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVFSTIK---EYEKSSEGA----------------------------------------------L
YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA
VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK
ELVTAWYIGFL----CLILASFLVYLAEK----------------GENDHFDTYADALWWGL------------------
-------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS-
-------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQS-AWRFYATNLSRTDLHST
WQYYERTVTVPMYSSQT-----QTYGASRLIPPLNQLELLRNLKSKSGLTFRKE---PQPEPSPS---------------
---------------------------QKVSLKDRVFSSP---RGVAAKGKGSPQAQ---------------------TV
RRSPSADQSLD-------------------------------------------------------------DSPSKVPK
SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIVE----------------DNKSCNCEF
VTEDLTPGLKVSIRAVCVMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQS---------------
---------------------RVDQIVGRGPTITDKDR------------------------------------TKGPAE
TELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV
LSMEKKLDF--LVSIYTQRMGIPPAETEAYFGAK----EPEPAPPYHSPEDSRDHAD-----KHGCII------------
------KIVRSTSSTGQRNYAAPPV--MPPAQCPPSTSWQ----------QSHQR--HGTSPV---GDH-GSLVRIPPPP
AHERSLSAYSGGNRA--------STEFLRLEGTPACRPSEAAL-------------------------------------
------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDALAS-------------CYAAV
APCAKVRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFGDVAWAGPRK-------------------------------
--------
>Gallus_gallus_KCNQ2
--------------------------------------------------------------------------------
--------------------------------------------------------------MVQKSRNGGVYPGPAA-E
KKLKVGFVGLDPGAPDSSRDGALLIAGSESTKRGSILSKPRSG--VSGSGKPPKRNAFYRKLQNFLYNVLERPRGWAFIY
-HAYV---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----FLLVFSCLVLSVFSTID---EYQNSSEGA----------------------------------------------L
YILEIVTIVVFGVEYFVR-----------------IWAAGCCCRY-RGWRGRLKFARKP-------FCVIDIMVLIASIA
VL------AAGSQGNVFATSALRSLRFLQILR-------------------------MIRMDRRGGTWKLLGSVVYAHSK
ELITAWYIGFL----CLILASFLVYLAEK----------------GENEHFDTYADALWWGL------------------
-------------------------------ITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFA----LPA--GILGS-
-------------------------------GFALKVQEQHRQKHFEKRRN---PAAGLIQA-AWRFYATNLSRTDLHST
WQYYERTVTVPMYSTQT-----QTYGASRLIPPLNQLELLRNLKSKSGLTFRKE---QQPEPSPS---------------
---------------------------QKVSLKDRVFSSP---RGAGTKGKGSPQAQ---------------------GI
RRSPSADQSIE-------------------------------------------------------------DSPSKVPK
SWS--FGDRSRARQAFRIKGAASRQNSE----------------EASLPGEDIPD----------------ENKSCNCEF
VTEDLTPGLKVSIRAVCIMRFLVS-----KRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKNLQSR--------------
----------------------VDQIVGRGSSMTNKDR------------------------------------TKGPAE
GELP-------------------------EDPSMMG----------------------------------RLGKVEK-QV
QSMEKKLDF--LVNIYMQRMGIPPTETEAYFGSK----EPDPAPPYHSPEDSREHID-----KNGCII------------
------KIIRSTSSMGQKNFSAPPA---PTNSCPPSTSCQQ---------QPYQRQSHGSSPV---GDP-GSLVRIPPPP
SHERSLSAYSGGHRA--------SAEYLRNEDIT-TKHHESAL-------------------------------------
------------------------RDSDTSISIPSVDHEELERSFSGFSISQSKENLDILNNG------------CYAAV
A---KIRPYIAEGESDTDSDLCTPCG-PPPRSATGEGPFSDMGWSAPRQ-------------------------------
--------
>Anolis_carolinensis_KCNQ2
-------------------