>Homo_sapiens_E2F1
--------------------------------------------------------------------------------
--------------------MALAGAPAGGPCAPALEALLGAG--ALRLLDSSQ------------------------IV
IISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQ----APRPTPSAPRPALGR--------PPVKRRLDLETD-----
HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTTVGVGGRLEG---------------LTQD
LRQLQESEQ------QLDHLMNI--CTTQ---LRLLSEDTDSQR------------------------------------
--------------------------------LAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAVDS------
---------------SENFQISLKSKQG-PIDVFLCPEETVGG-------------------------------------
--------------ISPGKTPSQEVTS-EEENRATDS-------------------------------------------
-----------------------ATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSR-----------------MGSLRA
PVDEDRLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE
GEGIRDLF--DCDFGDLTPLDF------
>Gorilla_gorilla_E2F1
--------------------------------------------------------------------------------
--------------------MALAGAPAGGPCAPALEALLGAG--ALRLLDSSQ------------------------IV
IISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQ----APRPTASAPRPALGR--------PPVKRRLDLETD-----
HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTTVGVGGRLEG---------------LTQD
LRQLQESEQ------QLDHLMNI--CTTQ---LRLLSEDTDSQR------------------------------------
--------------------------------LAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAVDS------
---------------SETFQISLKSKQG-PIDVFLCPEETVGG-------------------------------------
--------------ISPGKTPSQEATS-EEENRATDS-------------------------------------------
-----------------------ATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSR-----------------MGSLRA
PVDEDRLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE
GEGIRDLF--DCDFGDLTPLDF------
>Macaca_mulatta_E2F1
--------------------------------------------------------------------------------
--------------------MALAGAPAGGPCAPALEALLGAG--ALRLLDSSQ------------------------IV
IISAAQDASAPPAPTGPAAPAAGPCDPDLLLFATPQ----APRPTPSAPRPALGR--------PPVKRRLDLETD-----
HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTTVGVSGRLEG---------------LTED
LRQLQESEQ------QLDHLMNI--CTTQ---LRLLSEDTDSQR------------------------------------
--------------------------------YPWIGR-----RDLRSIADPAE-QMVMVIKAPPETQLQAVDS------
---------------SETFQISLKSKQG-PIDVFLCPEETVGG-------------------------------------
--------------ISPGKTPSQEATS-EEENRATDS-------------------------------------------
-----------------------ATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLSR-----------------MGSLRA
PVDEDRLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE
GEGIRDLF--DCDFGDLTPLDF------
>Mus_musculus_E2F1
--------------------------------------------------------------------------------
----------------------MAVAPAGGQHAPALEALLGAG--ALRLLDSSQ------------------------IV
IISTAPDVGAPQLP---AAPPTGPRDSDVLLFATPQ----APRPAPSAPRPALGR--------PPVKRRLDLETD-----
HQYLAGSS----GPFRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHTMVGIGKRLEG---------------LTQD
LQQLQESEQ------QLDHLMHI--CTTQ---LQLLSEDSDTQR------------------------------------
--------------------------------LAYVTC-----QDLRSIADPAE-QMVIVIKAPPETQLQAVDS------
---------------SETFQISLKSKQG-PIDVFLCPEESADG-------------------------------------
--------------ISPGKTSCQETSS--GEDRTADS-------------------------------------------
-----------------------GPAGPPP-SPPSTSPALDPSQSLLGLEQEAVLPR-----------------MGHLRV
PMEEDQLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVKEDFSGLLPGE------------------FISLSPPHEA-LDYHFGLEE
GEGIRDLF--DCDFGDLTPLDF------
>Rattus_norvegicus_E2F1
--------------------------------------------------------------------------------
----------------------MAVAPAGGQHAPALEALLGAG--ALRLLDSSQ------------------------IV
IISTAPDVGAPQVPTGPAAPPAGPRDPDVLLFATPQ----APRPAPSAPRPALGR--------PPVKRRLDLETD-----
HQYLAGSS----GPFRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SRTMVGIGQRLEG---------------LTQD
LQQLQESEQ------QLDHLMHI--CTTQ---LQLLSEDSDIQR------------------------------------
--------------------------------LAYVTC-----QDLRSIADPAE-QMVIVIKAPPETQLQAVDS------
---------------AETFQISLKSKQG-PIDVFLCPEESAEG-------------------------------------
--------------ISPGRTSYQETS---GEDRNADS-------------------------------------------
-----------------------GTAGPPP-SPPSTSPTLDPSQSLLGLEQEAVLPR-----------------IGNLRA
PMEEDRLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVKEDFSGLLPGE------------------FISLSPPHEA-VDYHFGLEE
GEGIRDLF--DCDFGDLTPLDF------
>Felis_catus_E2F1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------L--------PQVKRRLDLETD-----
HQYLAESS----GPARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHAAVGIGGRLEG---------------LTQD
LRQLQESER------QLDHLIHI--CTAQ---LRLLSEDSDSQRS-----------------------------------
-------------------------------TLAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAIDS------
---------------SETFQISLKSKQG-PIDVFLCPEESAGG-------------------------------------
--------------ISPGKTSSQGTAS-GEEDRAVDP-------------------------------------------
-----------------------ATTVPPP-SSPSSSPAADPSQSLLSLEQEPLLSR-----------------MGGLRA
PVDEDRLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVREDFSGLLPEE------------------FISLSPPHEA-LDYHFGLEE
GEGIKDLF--DCDFGDLTPLDF------
>Equus_caballus_E2F1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------AAPPRSAA--------PPVKRRLDLETD-----
HQYLAESS----GPTRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------SHAAVGIGGRLEG---------------LTQD
LRQLQESER------QLDHLIHI--CTTQ---LRLLSEDTDSQRY-----------------------------------
-------------------------------PCTAWRA-----ADLRSIADPAE-QMVMVIKAPPETQLQAVDS------
---------------SETFQISLKSKQG-PIDVFLCPEESAGG-------------------------------------
--------------ISPGKTLSQGTAS-GEEDRAANP-------------------------------------------
-----------------------ATTVPPP-SSPSSSPATDPSQSLLSLEQEPLLSR-----------------MGGLRA
PVDEDRLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVREDFSSLLPEE------------------FISLSPPHEA-LDYHFGLEE
GEGIRDLF--DCDFGDLTPLDF------
>Myotis_lucifugus_E2F1
--------------------------------------------------------------------------------
-----------------------ATGVCGGVGGQALRACLGRAR--GGLLDSWQ------------------------IV
IISIAQDTSAP-LPPAPAVRAASPRDPDLLLFATPQ----APRPTP-SPRPALGR--------PPVKRRLDLETD-----
HQYLAESS----GLARG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSRSADGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLIAKKSKNHIQWLG---------------------NHATVGIGGQLEG---------------LTKD
LQQLQENER------QLDHLIHV--CTTQ---LQLLSEDADSQRS-----------------------------------
-------------------------------TLAYVTC-----QDLRSIADPAE-QMVMVIKAPPETQLQAMDS------
---------------SEAFQISLKSKQG-PIDVFLCPEESAGG-------------------------------------
--------------ISPRKTPSQGATS-GEEDRAADP-------------------------------------------
-----------------------TPTVPPS-SSLPSTPDVDPSQPLLSLEQEPLLSR-----------------MGGLRA
AMDEDHLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVREDFSSLLPEE------------------FISLSPPHGA-LDYHFGLEE
GEGIRDLF--DCDFGDLTPLDF------
>Erinaceus_europaeus_E2F1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------VKRRLDLETD-----
HQYLAESS----GPPRG-----RGRHPGKGVKSPGEKSRYETSLNLT-TKRFLELLSHSSDGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLITKKSKNHIQWLG---------------------NHAAVGIGGRLEE---------------LTQD
LQQLQESER------QLDHLIHI--CTTQ---LQLLSEDSDSQR------------------------------------
-----------------------------------YPG-----LDLRSIADPAE-QTVMVIKAPPETQLQAVDS------
---------------AETFQISLKSKQG-PIDVFLCPEETVGG-------------------------------------
--------------ASPGKTPSQGTAS-GEEDRTADA-------------------------------------------
-----------------------ATTVPQP-----PSPAGDPSPSLLSLEQEPLVPR-----------------MGCLRA
PVDEDRLSPLVAA-------------------------------------------------------------------
------------------------DSLLEHVREDFSG-LPEE------------------FISLSPPLEA-LDYHFGLEE
GEGIKDLF--DCDFGDLTPLDF------
>Gallus_gallus_E2F1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------PQVKRKLNLETD-----
HQYIAESL----PAARG-----RARIPGRGAKSPGEKSRYETSLNLT-TKRFLELLSQSPDGVVDLNWAAEVLKVQ-KRR
IYDITNVLEG-IQLITKKSKNNIQWLG---------------------SQVAAGASSRQRL---------------LEKE
LRDLQAAER------QLDDLIQT--CTVQ---LRLLTEDPSNQSF-----------------------------------
---------------------------------AYVTC-----QDLRSIVDPSE-QMVMVIKAPPETQLQVSDP------
---------------GEAFQVSVRSTQG-PIDVFLCPEDSSGV-------------------------------------
--------------CSPVKSPFKAPAEELSPGSSQQ--------------------------------------------
------------------------------RASPLLHSAQDVNM--LLPEA--LLPG-T---------------ALPTKC
PTEDVSLSPLASM-------------------------------------------------------------------
------------------------DTLLEHGKDDFPGFLADE------------------FIALSPP-QP-QDYHFGLEE
GEGISELF--DCDFGDFTHLDF------
>Anolis_carolinensis_E2F1
--------------------------------------------------------------------------------
-----------------------------------FQELQFIG-----WKILLF------------------------DF
KVAISRN----------------------------------------WLKSTHPL--------ERVKRKLNLETD-----
HQYIAESF----QGNRG-----RARNAVKGVKSPGEKSRYETSLNLT-TKRFLELLSQSPDGVVDLNWAADVLKVQ-KRR
IYDITNVLEG-IQLITKKSKNHIQWLG---------------------SRSTVGGPSNCHG---------------LMKE
LQDLQDAEQ------QLDTLIQM--CTTQ---FKLLTEDLENKRK-----------------------------------
---------------------------------AYVTC-----QDLRSVVDPSE-QLVMVIKAPPETQMQVSDP------
---------------AEAFQIAVKSTQG-PIDVFLCPEESSEV-------------------------------------
--------------CSPTKSPQKVAVGQRTPESSQ---------------------------------------------
------------------------------AAAVVTTAATPVLLHPSQAEP--LLSGEN---------------TLPLKC
PGDDVSLSPLASV-------------------------------------------------------------------
------------------------DTLLQQGKDDFSSFLPAE------------------FIALSPP-QT-QDYHFGLEE
GEGISELF--DCDFGDFTSLDF------
>Xenopus_tropicalis_E2F1
--------------------------------------------------------------------------------
-------------------------------------ALWEAG----TFQVAEQ------------------------QI
VIISTPDVPAEAAGN------PGLSEAELMLFTTPQ----GPSTSYTAQRPDLGR--------PPVKRKLDLETV-----
SRYNQEAL----QTPRG-----KGKRPLKAVKSPGERSRYDTSLHLT-TKRFLELLSQSSDGVVDLNWAAQVLNVQ-KRR
IYDITNVLEG-IHLITKKSKNHIQWLG---------------------YTSYAEYNSRYQS---------------TLKD
CQKLEDQEK------QLDKLIHM--ANTQ---LKLFKEEILDTQQCT---------------------------------
--------------------------------FGYVTC-----QDLRSIADPSE-RMLMVIRYPPDTDMCVSDP------
---------------AEAFQMSLKSTQA-PIDVFLCPDDSSGV-------------------------------------
--------------CSPVTSPTKTSQAEPSSINQAEP-------------------------------------------
-----------------------LPSVQPKEESPASIPMLDIGLGLLSDMQEPFLPP-------------------ENEI
PLDSTLNCLPLSP-------------------------------------------------------------------
------------------------SNLLLDYRDAMPDFLPND------------------FISLSPA-SS-QEYSFGLQT
CEGAAELFNFDCDFSGLTALDL------
>Danio_rerio_E2F1_a
--------------------------------------------------------------------------------
------------------MSEGFISGQTSEDLLADFESLLNNG--SIDLSEDHQ------------------------IV
IISTPG-----TATTS-------TATGDILLFATPHHTSTGTTSLPDHRRPILGR--------PPVKRKLDLDSD-----
HQYICTSRTASNGPTPP-----ATPAPPRVPKLAVEKSRYDTSLNLT-TKRFLDLLAQSPDGVVDLNWASQVLDVQ-KRR
IYDITNVLEG-IHLISKKSKNNIQWLG---------------------NRIDGASLARFQE---------------LQKE
VSELTEAEE------KLDELINK--CSLQ---LRLLTEDTHNKKY-----------------------------------
-------------------------------PLRYVRC-----QDLRNTVDPPD-QIIMVIRAPAETAMQVSEP------
---------------SEGYQISLKSSKG-PIDVFLCPEDSSGV-------------------------------------
--------------CSPVTDCSPAKSSNQSPAKSDPA-------------------------------------------
-----------------------SQEVTSTPTTLPSSSPLPLHTDSESFLDSDPFSGIC---------------------
AMPDFDLSPLDSD-------------------------------------------------------------------
------------------------FLLERSGAADGLGLPLDS------------------FICLSPP-HS-QDYHFGLED
HEGVSELF--DCDFSDLVPLEF------
>Takifugu_rubripes_E2F1_a
--------------------------------------------------------------------------------
------------------------------------ETLLNSG--SIDLSQDHQ------------------------IV
IITSPSNEGLHPGSAP-------TSTGEILLFATPQ--GPADVGLHDKRRPALGR--------PPVKRKLDLDSD-----
HQYVSTTR-PCIGQAP------STPAPPRVPRNTTEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR
IYDITNVLEG-IHLISKKSKNNIQWLG---------------------NRVDTALVSRHKE---------------LQKE
VCDLTEAEE------QLDQLISK--CSLQ---LRLLTEDPQNNT------------------------------------
--------------------------------WGYVRC-----QDLKRSFDSPD-QLLMVIRAPPETQMQVSEP------
---------------SKGFEMSLKSTQG-PIDVFLCPEDSSGA-------------------------------------
--------------CSPVSGSSPTKTN-TEPSLVPPV-------------------------------------------
-----------------------AQPTDQSNASGSTATLQLHHWPVSSAGPSLHAPVP----------------------
DMPDFDLSPLSAA-------------------------------------------------------------------
------------------------DFLN----GEGFSLPLDG------------------FINLSPP-HS-HDYHFGLED
HEGISELF--DCDFGDLTHVLG------
>Tetraodon_nigroviridis_E2F1_a
--------------------------------------------------------------------------------
----------------------LITGQTSEDILADFETLLNSG--SIDLGEDHQ------------------------IV
IITSPGNEGLHPGSAP-------TSTGEILLFATPQ--GPADVGLQDKRRPALGR--------PPVKRKLDLDSD-----
HQYVSTTR-PCIGQAPP-----STPAPPRVPRNLTEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR
IYDITNVLEG-IHLISKKSKNHIQWLG---------------------NRVDTALVSRHKE---------------LQKE
VCDLAEAEE------QLDQLVSK--CSLQ---LRLLTEDPQNNT------------------------------------
--------------------------------WGYVRC-----QDLKKSVDSPD-QLLMVIRAPPETQMQVSEP------
---------------SKGFEMSLKSTQG-PIDVFLCPEDSSGA-------------------------------------
--------------CSPVTGSSPAKA--TGPSLVP---------------------------------------------
-----------------------EQTTDQSKTRGSTALLEESSSSPASTSSTVTAASQQDSSSLPMG------NDSGYVS
DMPNFDLSPLSAA-------------------------------------------------------------------
------------------------DFLN----GEGFPLPLDG------------------FINLSPP-HS-HDYHFGLED
HEGISELF--DCDFGDLTHVLE------
>Gasterosteus_aculeatus_E2F1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------EILLFATPQ--GSVDVGVQDKRRPALGR--------PPVKRKLDLDSD-----
HQYVSTTR-PSIGQAPP-----S------IPRTATEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR
IYDITNVLEG-IQLISKKSKNNIQWLG---------------------NRVDAALVSRQKD---------------LHGE
VCDLKDAEE------QLDQLISK--CNLQ---LRLLTEDTQNNT------------------------------------
--------------------------------LGYVRC-----QDLKKSFDSPD-QLVMVIRAPPETQMQVSEP------
---------------SKSYQVSLKSTRG-PIDVFLCPEESSGV-------------------------------------
--------------CSPVTGGSPSKP---DPLLVPPP-------------------------------------------
-----------------------ARPTDQSQARNSTAAQDETLLSPESLLGGDPFSGLG---------------------
EMPDFNLSPISSS-------------------------------------------------------------------
------------------------DFLN----ADGIPLPLDG------------------FINLSPP-HS-HDYHFGLED
HEGISELF--NCDFDDLSQVLG------
>Oryzias_latipes_E2F1_a
--------------------------------------------------------------------------------
----------------------CCRSPLGGRQCHDFETLLNSG--SIDLSQDHQ------------------------IV
IITSPSNEGLHPLAAP-------SSTGEILLFATPQ--SHADAGGQDRRRPALGR--------PPVKRKLDLDSD-----
HQYVSTTR-SSASQAPP-----STPAPPRVPRSTAEKSRYDTSLNLT-TKRFLNLLSQSADGVVDLNWASQVLDVQ-KRR
IYDITNVLEG-IQLISKKSKNHIQWLG---------------------NRIDASMVSRHKE---------------LQRE
ACDLTEAEE------QLDELIAK--CNLQ---LRLLTEDPQNKK------------------------------------
--------------------------------LGYVRC-----QDLRQSFDSPD-QLVMVIRAPPETQMQVSEP------
---------------SEGYQVSLKSTRG-QIDVFLCPEDSSGV-------------------------------------
--------------CSPVTGTSPSKT---G--ADPSL-------------------------------------------
-----------------------ASPLLPHPAE---PPPQFPFPPTESLLGGDPFSSLG---------------------
DMADFDLSPLSSS-------------------------------------------------------------------
------------------------DFLN----GEGLPLALDN------------------FINLSPP-QS-HDYHFGLED
HEGISELF--DCDFDELSHVLG------
>Homo_sapiens_E2F2
------------------------------------------------------------------------------ML
QGPRALASAAG--------------QTPKVVPAMSPTELWPSGLSSPQLCPAT---------------------------
-------ATYYTPLYPQTAPPAAAP--GTCLDATPHGPEGQVVRCLPAGR-------------LPAKRKLDLEGI-----
GRPVVPEFPTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE
LKELMNTEQ------ALDQLIQS--CSLS---FKHLTEDKANKR------------------------------------
--------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------
--------------TEDNLQIYLKSTQG-PIEVYLCPEEVQEP-------------------------------------
--------------DSPSEEPLPSTSTLCPSP------------------------------------------------
-----------------------DSAQPSSSTDPSIMEPTAS-----SVPAPAPTPQQ--------------APPPP--S
LVPLEATDSLLELP------------------------------------------------------------------
------------------------HPLLQQTEDQFLSPTLA--------------CS-SPLISFSPSLDQ-DDYLWGLEA
GEGISDLF-DSYDLGDLLIN--------
>Pongo_abelii_E2F2
------------------------------------------------------------------------------ML
QGPRALASAAG--------------QTPKVVPAMSPTELWPSGLSSPQLCPAT---------------------------
-------ATYYTPLYPQTAPPAAAP--GTCLDATPHRPEGQVVRCLPAGR-------------LPAKRKLDLEGI-----
GRPAVPEFPTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE
LKELMNTEQ------ALDQLIQS--CSLS---FKHLTEDKANKR------------------------------------
--------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------
--------------TEDNLQIYLKSTQG-PIEVYLCPPAVLDK-------------------------------------
--------------DSPSEEPLPSTSTICPSP------------------------------------------------
-----------------------DSAQPSSSTDPSIMEPTAS-----SLPAPAPTPQQ--------------APPPP--S
LVPLEATDSMLELP------------------------------------------------------------------
------------------------HPLLQQTEDQFLSPTLA--------------CS-SPLISFSPSLDQ-DDYLWGLEA
GEGISDLF-DSYDLGDLLIN--------
>Macaca_mulatta_E2F2
------------------------------------------------------------------------------ML
QGPRALVSAAG--------------QPPKVVPAMSPTELWPSGLSSPQLCPAT---------------------------
-------TTYYTPLYPQTAPPAVAP--GTCLDATPHGPEGQVVRCLPAGR-------------LPAKRKLDLEGI-----
GRPAVPEFPTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE
LKELMNIEE------ALDQLIQS--CSLS---FKHLTEDKANKR------------------------------------
--------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------
--------------TEDNLQIYLKSTQG-PIEVYLCPEEVQEP-------------------------------------
--------------DSPSEEPLPSTSTLCPSP------------------------------------------------
-----------------------DSAQPSSSTDPSIMEPTAS-----SVPAPAPTPQQ--------------APPPP--S
LVPLEATDSMLELP------------------------------------------------------------------
------------------------HPLLQQTEDQFLSPTLA--------------CS-SPLISFSPSLDQ-DDYLWGLEA
GEGISDLF-DSYDLGDLLIN--------
>Mus_musculus_E2F2
------------------------------------------------------------------------------ML
RAPRTLAPATA--------------QPTKSLPALNPTELWPSGLSSPQLCPATT--------------------------
------ATTYYTSLYTQTVPSSVAL--GTCLDATPHGPEGQIVRCAPAGR-------------LPAKRKLDLEGI-----
GRPTVPEFRTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKSKNNIQW-----------------------VGRELFEDPTRPS---RQQ--------QLGQE
LKELMNAEQ------TLDQLIQS--CSLS---FKHLTEDNANKK------------------------------------
--------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------
--------------AEENLQIYLKSTQG-PIEVYLCPEEGQEP-------------------------------------
--------------DSPAKEALPSTSALSPIP------------------------------------------------
-----------------------DCAQPGCSTDSGIAETIEP-SVLIPQPIPPPPPPP--------------LPPAP--S
LVPLEATDNMLELS------------------------------------------------------------------
------------------------HPLLQQTEDQFLSPILA--------------AN-SPLISFSPPLDQ-DEYLWGMDE
GEGISDLF-DSYDLGDLLIN--------
>Rattus_norvegicus_E2F2
------------------------------------------------------------------------------MG
CGLVSPAGVSQ--------------AWRERGGAAGPQLLVLKTLGKDSLCLSKER-------------------------
MTSSPFRGPWILELEPKRGGGVFVLF-PNVGTSLGCGTEPGSPLGLGGCRSHPDKGQLWGCDGHQAKRKLDLEGL-----
GRPTVPEFRTPKGKCIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKSKNNIQW-----------------------VGRGIFEDPTRPA---KEQ--------QLGQE
LKELMNAEQ------TLDQLIQS--CTLS---FKHLTEDNANKK------------------------------------
--------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------
--------------AEENLQIYLKSTQG-PIEVYLCPEEGQEA-------------------------------------
--------------DSPTKEALPSTSTLSPVP------------------------------------------------
-----------------------DCAQPGCSTDSGLAETIES-----SVLMPQPVPPPL-------------PPPPPAPS
LVPLEATDNMLELS------------------------------------------------------------------
------------------------HPLLQQTEDQFLSPILT--------------AS-SPLISFSPPLDQ-EEYLWGMDE
GEGISDLF-DSYDLGDLLIN--------
>Canis_familiaris_E2F2
------------------------------------------------------------------------------ML
RGPRAPAAAAG--------------PPSKALPAMSPTEPWPPGLSSPQLCPAT---------------------------
-------ATYCTSLYPQTVPPPAAA--GTCLDATPHGPEGQAVRCVPAGR-------------LPAKRKLDLEGI-----
GRPAIPEFRTPKGKCIRV-EGLPSP---RTPKSPGEKTRYDTSLGLL-TKKFIYLLSESKDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KQQ--------QLGQE
LKELMSMEQ------ALDQLIQS--CSLN---FKHLTEDKANKR------------------------------------
--------------------------------LAYVTY-----QDIRAVGNFKE-QTVIAVKAPPQTRLEVPDR------
--------------NEENLQIYLKSTQG-PIEVYLCPEEVQDP-------------------------------------
--------------DSPAKERLPPASTLGPSP------------------------------------------------
-----------------------DSTQPSSSTDPGMTDPVAS-----SASHPPPAPPP--------------PPPPP--P
LVPLEATDSMLELP------------------------------------------------------------------
------------------------HPLLQQTEDQFLSPTLP--------------CS-SPLISFSPPLDQ-DDYLWGLDG
GEGISDLF-DSYDLGDLLIN--------
>Felis_catus_E2F2
------------------------------------------------------------------------------ML
RGPRALAPAAG--------------PPSKGLPAMSPTELWPPGLSSPQLCPAT---------------------------
-------TTYYTSLYPQTVPPTAAP--GTCLDATPHGPEGQAVRCVPAGR-------------LPAKRKLDLEGI-----
GKPAVPEFRTPKGKCIRL-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESKDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPTRPG---KRQ--------QLGQE
LKELMSTEQ------ALDQLIQT--CSLN---FKHLTEDKANKR------------------------------------
--------------------------------LAYVTY-----QDIRAVGSFKE-QTVIVVKAPPQTRLEVPDR------
--------------SEENLQIYLKSTQG-PIEVYLCPEEVQEP-------------------------------------
--------------DSPTKDPFPSPSPLGPIP------------------------------------------------
-----------------------DSTQPSSSTDPGMTEPMASPGPALTPQQALQLPAP--------------PPPPL--P
LVPLEATDSMLELP------------------------------------------------------------------
------------------------HPLLQQTEDQFLSPTLP--------------CS-SPLISFSPPLDQ-DDYLWGLDG
GEGISDLF-DSYDLGDLLIN--------
>Myotis_lucifugus_E2F2
------------------------------------------------------------------------------ML
RGPRAPAPAAA--------------LPLKGLPALSPTELWPPGLGSPQLCPVT---------------------------
-------TAYYTSLYPQTVPPATVP--GTCLDATPHGPEGQAVRCVPAGR-------------LPAKRKLDLEGI-----
GRPAVLEFQTPKGKLIRV-DGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESKDGVLDLNWAAEVLDVQ-KRR
IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGALEDPTRPG---KQQ--------QLGQE
LKELMSMEQ------ALDQLIQS--CSLN---FKHLTEDKANKK------------------------------------
--------------------------------LAYVTY-----QDIRAIGTFKE-QTVIAVKAPPQTRLEVPDR------
--------------NEENLQIYLKSTQG-PIEVYLCPEEMQEP-------------------------------------
--------------DSPAKEPVPSTSTLSPTP------------------------------------------------
-----------------------DSAQPCSSTNPGILEPTASPDLSPAPSLTSQQALL--------------PPP----S
LVPLEATDSMLELP------------------------------------------------------------------
------------------------QPLLQQTEDQFLTD------------------S-SPLISFSPPLDQ-DDYLWGLDG
GEGISDLF-DSYDFGDLLIN--------
>Monodelphis_domestica_E2F2
------------------------------------------------------------------------------ML
RIPKGVSPAPGGSAPAAPQKPPQPLQIKKALPVVS--PVWTPDVRSPQGGPVP---------------------------
-------ASHFTPLYPPMVAAVAPAAPGSCLDATPQGPEIRASR-ASAGR-------------LPAKRKLDLEGM-----
GRQGLSEFRTPKGKCGGG-EGLPSP---KTPKSPGEKTRYDTSLGLL-TKKFIYLLSESEDGVLDLNWAAEVLEVQ-KRR
IYDITNVLEG-IQLIRKKAKNNIQW-----------------------VGRGMFEDPAGPR---KQQ--------SLGQE
LKDLSDTER------VLDQLIQS--CTSD---LKHLTEDETNQR------------------------------------
--------------------------------YPSWRRGPRMGGDIRAIGNFKD-QTVIAVKAPPETRLEVPDL------
--------------REENLQIYLKSTNG-PIEVYLCPEDNRE--------------------------------------
--------------AGGSSQE----------A------------------------------------------------
-----------------------PPSDPGP-------------------------------------------FPGRSSS
PSS-----------------------------------------------------------------------------
------------------------------------------------------------------------SCSLDLIA
PPGRCLAI-GAFFLSVWA----------
>Pelodiscus_sinensis_E2F2
------------------------------------------------------------------------------ML
RVPKGVSSA--------------PQQQKKIMPVMSSADLVTSSLSSPQMHSIP---------------------------
-------ASYFMQVYPQTVAAAPPPR-GSCLYATPHGPEIKAIRSASAGR-------------LPAKRKLDLEGT-----
GQPGLPEFRTPKGKGRMV-TRIPSPRTTKAPKSPGEKTRYDTSLGLL-TKKFIHLLSESEDGVLDLNRAAEVLEVQ-KRR
IYDITNVLEG-IQLIRKKSKNNIQW-----------------------MGTGIFEDTSVTV---KQQ--------SLRQE
LAELAKTER------KVDELIQD--CTLQ---LKHLTEDETNQR------------------------------------
--------------------------------LAYVTY-----QDIRAIGNFQE-QTVIAVKAPPETKLEVPDF------
--------------SEENVQLHLKSTNG-PIEVYLCPEEILD--------------------------------------
--------------DSPAKESSFLTPSLQDSS------------------------------------------------
-----------------------DGTDPSPGKGKGGLWPGLA-----WSPLPSPVLWGL-------------TFPFVAAA
APLMEVEDGLLDVP------------------------------------------------------------------
------------------------HHLLQQTEDQLPYGD-----------------P-APFVSFSPPLDQ-DDYLWGLEG
GEGVSDLF-EAYDLGDLLKN--------
>Takifugu_rubripes_E2F2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------AKRKLDLED------
-PLYMPEFRTPKGKCNIA-ARLTSP---RTPKSPGERTRYDTSLGLL-TKKFVGLIAESPDGVLDLNWATEVLEVQ-KRR
IYDITNVLEG-VQLIRKKSKNHIQW-----------------------LVGDVFEGGTGGG---QKAC-------TLRKE
IGDLEQAEK------CLDELILS--STGQ---LKQLTEHGDNQR------------------------------------
--------------------------------LGYVTY-----HDIRSIGSLQD-QTVIAVKAPADTKLEVPDTE-----
--------------GE-SLQIYLKSKNG-PIEVYLCPEDGLED-------------------------------------
--------------ASPVKSVSTPKKEFPPTVCTSH--------------------------------------------
-----------------------TTSTAPPSCSIKEEPVEFTIRIPAHIPAAAAASSS---------------------S
ILDVEGLLG---LP------------------------------------------------------------------
------------------------PSLLQITEDQLPSATFTPD------------PN-TPFVSFSPPLDH-DDYLWSLDD
GEGVSDFF-DTYDLGDLLSN--------
>Tetraodon_nigroviridis_E2F2_a
------------------------------------------------------------------------------MM
RMPKGVSAASGRPAAG----LSCSQTKMKLLSAGVKTEFFSAGLSSPLMNAVP---------------------------
-----------AGYFTQICNTTAAEQRANSLYSTPHGPEAKPIRASSGRM--------------PAKRKLDLED------
-PLYMPEFRTPKGKCNIA-ARLTSP---RTPKSPGERTRYDTSLGLL-TKKFVGLIAESPDGVLDLNWATEVLEVQ-KRR
IYDITNVLEG-VQLIRKKSKNHIQW-----------------------LVGDVFEGGAGGG---QKAG-------ALRKE
LGDLERAEK------CLDELILS--STAQ---LKQLTEYEDNQR------------------------------------
--------------------------------LGYVTY-----QDIRSIGSFQD-QTVIAVKAPADTKLEVPDTE-----
--------------GQGSLQIYLKSKNG-PIEVYLCPEEALED-------------------------------------
--------------ASPVKSASTPKKDILQTICPPAPA------------------------------------------
-----------------------TSSTAPPSCSIKEEPVESK----PSSAHVAAASSA---------------------S
ILDVEGLLG---LP------------------------------------------------------------------
------------------------PSLLQITEDQLPSASFAPD------------PN-TPFVSFSPPLDH-DDYLWSLDD
GEGVSDFF-DSYDLGDLLSN--------
>Gasterosteus_aculeatus_E2F2_a
------------------------------------------------------------------------------MM
RMPKGVSPAPGRQKIK----VVS--------TAGGKHEFFSTGLSSPPMSTVP---------------------------
-----------PGYFTQICNTAAGEQRANSLYSTPHGPEAKPIRSSCGRL--------------PAKRKLDLED------
-PLYLPEFRTPKGKCSIA-ARIPSP---RTPKSPGERTRYDTSLGLL-TKKFVGLIAESPDGVLDLNWATEVLEVQ-KRR
IYDITNVLEG-VQLIRKKSKNNIQW-----------------------LVGDVFEGGASGG---EKAC-------ALRKE
LGELERVER------SLDDLVQS--STAQ---LKQLTEYEDNKRYPLR--------------------------------
------------------------------CTLGYVTY-----QDIRSIGTLRD-QTVIAVKAPADTKLEVPDTA-----
--------------GQGSLQIYLKSKNG-PIEVYLCPEEGLED-------------------------------------
--------------ASPGKSAATPIKEFSKPLDPPT--------------------------------------------
-----------------------ATAMAPPSYSAKEEPAEP------TLLLEAVDSLC---------------------P
KELINGLLG---LP------------------------------------------------------------------
------------------------PSLLQLTDDQLPCTSFAPD------------PN-APFVSFSPPLDH-DDYLWSLED
SEGVSDFF-DTYDLGELLKS--------
>Hydra_magnipapillata_E2F2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------MQPLQPIIFTTFKTPSKVFMA------------------NSQTKQIIRSAP------
-QPIAPATFKTKLNSPAL------EEKLAVQKSPACERRYETSLGIL-TKRFVSLLRNSVSGILDLNQAAELLDVQ-KRR
IYDITNVLEG-IGVIEKNSKNNIKWVG---------------------AKHLENQNDNIADVENQEEAILATNLVDLHQD
IEDLKLSEA------KLDELIQQ--CQNE---MKQCSGAKHYNK------------------------------------
--------------------------------HSYVTY-----QDIRGIKDFNN-KTVIAIKAPPETKLEVPDP------
---------------NESIQIWLKSSNG-PIDVYLCPENKENV-------------------------------------
--------------PPSNDRLDECAYSDSTSSVSEFSP------------------------------------------
------------------------FNNENLCSPGNLSQSSGYFDECQFSSYDANTTLS----------------------
SMNCDALHINKLDS------------------------------------------------------------------
------------------------EDFIAYNESCYQNELSIS-----------------PLISLEPNFKA-EDYLFSLDC
NEGISDLF----DVDTFL----------
>Homo_sapiens_E2F3
------------------------------------------------------------------------------MR
KGIQPALEQYLVT-------------AGGGEGAAVVAAAAAASMDKRALLASPGF-AAAAAAAAAPGAYIQILTTNTSTT
SCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALGRGGSG--GGGGPPAKRRLELGESG----
HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE
VTELSQEEK------KLDELIQS--CTLD---LKLLTEDSENQR------------------------------------
--------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDS------
--------------IES-LQIHLASTQG-PIEVYLCPEE-TET-------------------------------------
--------------HSPMKTNNQDHNGNIPKP--ASK-------------------------------------------
---------------------------DLASTNSG--------------HSDCSVS------------------------
---MGNLSPLASP-------------------------------------------------------------------
------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE
EEGISDLF-DAYDLEKLP-LVEDFMCS-
>Macaca_mulatta_E2F3
------------------------------------------------------------------------------MR
KGIQPALEQYLVT-------------AGGGEGAAVVAAAAAASMDKRALLASPGF-AAAAAAAAAPGAYIQILTTNTSTT
SCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALGRGGSG--GGGGPPAKRRLELGESG----
HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE
VTELSQEEK------KLDELIQS--CTLD---LKLLTEDSENQRYP----------------------------------
--------------------------------LSYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDS------
--------------IES-LQIHLASTQG-PIEVYLCPEE-TET-------------------------------------
--------------HSPMKTNNQDHNGNIPKP--TSK-------------------------------------------
---------------------------DLASTNSG--------------HSDCSIS------------------------
---MGNLSPLASP-------------------------------------------------------------------
------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE
EEGISDLF-DAYDLEKLP-LVEDFMCS-
>Oryctolagus_cuniculus_E2F3
------------------------------------------------------------------------------MR
KGIQPALEQYLVT-------------AGGGEGAAVVAAAAAAAMDKRALLASPG----FAAAAAAPGAYIQILTTNTSTS
SCSSSLQSGAVAAGPLLPSAPGAEPTAGSLLYTTPHGPSSRAGLLQQAPAPGRGGSG--GGGGPPAKRRLELGESG----
HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE
VTELSQEEK------KLDELIQS--CTLD---LKLLTEDSENQR------------------------------------
--------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDS------
--------------IES-LQIHLASTQG-PIEVYLCSEE-TET-------------------------------------
--------------HSPVKTNNQDHNGNIPKP--TSK-------------------------------------------
---------------------------DLASTNSG--------------HSDCSIS------------------------
---MANLSPLASP-------------------------------------------------------------------
------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE
DEGISDLF-DAYDLEKLP-LVEDFMCS-
>Felis_catus_E2F3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------LQAKRRLELGESG----
HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE
VTELSQEEK------KLDELIQT--CTLD---LKLLTEDSENQR------------------------------------
--------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------
--------------IES-LQIHLASTQG-PIEVYLCPEE-TET-------------------------------------
--------------HSPMKTNNQDHNGNIPKP--PSKEVVTEFPPSLPDPS-----------------------------
------------VMGTRH---------DLASTNSG--------------HSDCSIS------------------------
---MANLSPLASP-------------------------------------------------------------------
------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE
EEGISDLF-DAYDLEKLP-LV-------
>Dasypus_novemcinctus_E2F3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------PSFVLQAKRRLELGESG----
HQYLSDGLKTPKGKGR---AALRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSEDGGMLA---QCQG--------LSKE
VTELSQEEK------RLDELIQS--CTLD---LKLLTEDSENQR------------------------------------
--------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------
--------------LES-LQIHLSSTQG-PIEVYLCPEE-TET-------------------------------------
--------------HSPMKTNNQDHNGNIPKP--TSKAQRSEFHFFLLQPP-----------------------------
------------NIAARIGVIIEIPISDLASTNSG--------------HSDCSVS------------------------
---MANLSPLASP-------------------------------------------------------------------
------------------------ANLLQQTEDQIPSNLEG------------------PFVNLLPPLLQ-EDYLLSLGE
EEGISDLF-DAYDLEKLP-LV-------
>Monodelphis_domestica_E2F3
------------------------------------------------------------------------------MR
KGIQPALEQFLVT-------------AGGGEGAAAAAAAAAASMDKRALLASPG------FPAAAPGTYIQILTTNTTTT
SCSSSLQSGGAAAGPQHTNVPGVEQTAGSLLYSTPHGPSSRAGLLQQQPALGRGG-----GGGPPAKRRLELGESG----
HQFLSDGLKTPKGKGR---AAVRSPDSPK------KKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNKAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNVQW-----------------------MGCSLSDDGGMLA---QCQG--------LSKE
VTELSQEEK------RLDELIQS--CTLD---LKLLTEDSENQK------------------------------------
--------------------------------LAYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------
--------------LES-LQIHLSSNQG-PIEVYLCPEE-NET-------------------------------------
--------------HSPVKSYNQDHNGNIPKP--SSK-------------------------------------------
---------------------------DVASTNSG--------------HADCSIS------------------------
---MANLSPLASP-------------------------------------------------------------------
------------------------TNLLQQTEDQIPSNLEG------------------PFVNLLPPLIQ-EDYLLSLGE
EEGISDLF-DAYDLEKLP-LVEDFMCS-
>Taeniopygia_guttata_E2F3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------AKRRLELGGSG----
HQYLAEGLKTPKGKGR---AATRSPDSPKTPKSPSEKTRYDTSLGLL-TKKFIQLLSQSPDGVLDLNRAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLSEDGGMLA---QRQG--------LTKE
VTELTQEEK------KLDELIQS--CTLD---LKLLTEDSENQRYPFS--------------------------------
-----------------------------QNLQTYVTY-----QDIRKISGLKD-QTVIVVKAPPETRLEVPDP------
--------------VES-ALIHLSSTQG-PIEVYLCPEE-NDA-------------------------------------
--------------LSPMKTYSQDHNGNISKT--ISK-------------------------------------------
---------------------------EVASANSG--------------QGDCSVN------------------------
---MATISPLASP-------------------------------------------------------------------
------------------------ANLLQQTEDQIPSNFEG------------------PFLNLLPPLLQ-EDYLLSLGD
EEGISDLF-DAYDLEKLPSLMDEFIYS-
>Xenopus_tropicalis_E2F3
------------------------------------------------------------------------------MR
KGTQGGHEKLLLP-------------GLQGTDKGSGLAGGFIAGGGGVVGAGGG--------------------------
---GYVQIISSPGPPLHHHGLCIPEQAASFIYSTPHGPATRAGQLQP------------ALGRPPAKRRLELGDGS----
HQYLSDGLKTPKGKGR---AVTHCPDSPKTPKSPLEKTRYDTSLGLL-TKKFIQLLSQSSDGVVDLNRAAEVLKVQ-KRR
IYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCTLPDDGGNLA---KSQE--------LSKE
LSELAQEEN------KLDELIKN--CTLD---LKHLTENAENQRYP----------------------------------
--------------------------------FSYVTY-----QDIRKISGLKE-QTVIVIRAPPETRLEVPDP------
--------------VES-LQIHLSSSQG-AIEVYLCPEE-SES-------------------------------------
--------------SSPVKQCNQDHNGNVSKPKPHSK-------------------------------------------
---------------------------DSLSPNME--------------NVNCSVE------------------------
---G--ISPLTSP-------------------------------------------------------------------
------------------------TNLLQQTEDQISLNMDA------------------PFVNLLPPLMQ-EDYLLSLGD
EEGISDLF-DAYELEKLP-SLDDFMCS-
>Danio_rerio_E2F3_a
------------------------------------------------------------------------------MR
KGGSSVPGQVMLT-------------GVVRAEQHG--VFTAVSDRRCA--------------------------------
------VYSNATRIQINTPPS------TNNGCVPEASADSLYTTPLQGSTHGTGLRP--TLGRPPAKRRLELDITD----
HQY-SEPAKTLRSRKG-----ALKLKIPKAPKTPPEKTRYDTSLGFL-TKKFCQLLAQSSDGVLDLNKAAIVLNVQ-KRR
LYDITNVLEG-VRLIKKKSKNNIQW-----------------------LGSSLPSDGGLPSPAMQSHS--------LARE
MLALTQEER------RLDELIQT--CTRN---VQQMTEEIHSQK------------------------------------
--------------------------------YAYVTY-----QDIRRIKSLKD-QTVIAIKAPSETKLEVPDP------
--------------KES-LQVHLSSSKG-PIDVFLCTDG-GDS-------------------------------------
--------------GSPLQNG-LDVNGNHPAFLKVS--------------------------------------------
-------------------------QEAASDGPADNVKMNG--------NSNASVNGF--------------------GP
VSGNAPMSPLSSSL------------------------------------------------------------------
------------------------SSILQQPEEAIP------------------------FVPLSPALLS-DEYMLGLGD
EQGISDLF-DSCDLD---TLALDDLLRI
>Takifugu_rubripes_E2F3_a
------------------------------------------------------------------------------MR
RGISSASEKVILT-------------GVGGSSLDSNIILTTLSDRLNP--------------------------------
------GQSNATFIQIITTPPPCNVTQT-NVCLSEPQINSIYTTPQQGAANGARQRP--ALGRPPAKRRLALDDSD----
HQHQPEPIRTP-RGKGPT-ANGTRIKTPKTPKSPPEKTRYDTSLGLL-TKKFVELLGQSSDGVLDLNLAAETLQVQ-KRR
LYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLLEEEGSLS---QRQR--------LTDE
VSALGEEEQ------RLEQLIQR--CSTD---MRHMSELSSNQK------------------------------------
--------------------------------YAYITY-----QDIKQLGNLRD-QTVIVVKAPTDTKLEVTDP------
--------------DES-LSIHLTSTQG-PIDVLLCPDDDSHP-------------------------------------
--------------TSPVKNGGTDINGNSPFL------------------------------------------------
---------------------------KVLQAPSPGAPP-----------AAAAVS------------------------
---VTTLSPISSPY------------------------------------------------------------------
------------------------TSLLQQTEDQIPTSL-G------------------PFLNLAPPLLEQDDYLLGLGD
DQGISDLF-DACDFDKIRSLGLDDLLCS
>Tetraodon_nigroviridis_E2F3_a
------------------------------------------------------------------------------MR
RGISSAPEKVILT-------------GVGGSSLDSNIILTTLADRLNP--------------------------------
------GQSNATFIQIITTPPPCNVTRT-NVCLSEPQINNIYTTPQQGAANGAGQRP--ALGRPPAKRRLALDDSD----
HQHQSEPIRTP-RGRGAT-ANGTRIKAPRTPKSPPEKTRYDTSLGLL-TKKFVELLGQSSDGVLDLNLAAETLQVQ-KRR
LYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLLEEEGSLS---QRQS--------LTDE
VSALGEEEQ------RLEQLIQT--CSKD---MRCMSELSSNQKFS----------------------------------
-------------------------------TYAYITY-----QDIKQLGNLKD-QTVIVVKAPTDTKLEVTDP------
--------------DES-LSIHLTSTKG-PIDVLLCPDDDNDP-------------------------------------
--------------KSPVKNGGTDINGNSPYPG-----------------------------------------------
---------------------------SVAAAPSPGPPPPA--------AAAAAVS------------------------
---ITTLSPISSPY------------------------------------------------------------------
------------------------TSLLQQTEDQIPTSL-G------------------PFLNLGPPLLEQDDYLLGLGD
DQGISDLF-DACDFDKIRSLGLDDLLCS
>Gasterosteus_aculeatus_E2F3_a
------------------------------------------------------------------------------MR
RGISSAPDKVILT-------------GVGG-SLDNNIILTALTDRLNA--------------------------------
------GQSNATYIQIITTPPPCNITQTSNVCLSEPQINNIYTTPQQAGANGTGQRP--TLGRPPAKRRLALDDSD----
HQYQSEPVRTRGRVGTAV-ANGARPKTPRTPKSPPEKTRYDTSLGLL-TKKFVDLLAQSSDGVLDLNLAAETLQVQ-KRR
LYDITNVLEG-IHLIKKKSKNNIQW-----------------------MGCSLLEVEGALS---QRQR--------LTAE
VSAMGEEEQ------RLEQLIQG--CSLD---MRRMSELQSNQK------------------------------------
--------------------------------YAYVTY-----QDIKQLGNLRD-QTVIVVKAPTDTKLEVADP------
--------------DEN-LSIHLTSTKG-PIEVLLCPDEENDP-------------------------------------
--------------RSPVKDGGMDINGNSPFLKVLQG-------------------------------------------
------------------------PTCSSASTIQSLAPP----------SSSSAVS------------------------
---VTTLSPISSPY------------------------------------------------------------------
------------------------TSLLQQTEDQIASSL-G------------------PFLNLGLPLLGQEDYTLDLGD
EHGISDLF-DACDFDKMPSLGLDDLLCS
>Ciona_intestinalis_E2F3
--------------------------------------------------MDNSRVFSTTTAREIFTNNLASVSPQCSSK
SLPSNELHLTPSQDDTHQWLYGGHDMHGATDMSIVTVESQNNRNTAQVKRKLELQ-------------------------
----------SSSSGSMNSYLMSESQIQQLQTQNFVNN--------YNKPPSFKSPLKRAKSVSERKVLATNPPSR----
KRKMSTAGSVASGSPS-------------------EKSRYDTSLGLL-TKRFTQLMRNSSDGILDLNQAADILAVQ-KRR
IYDITNVLEG-IGLIEKRSKNNVQWVAC--------------------PNTESDHSSEIEKQ-------------ETQNE
VDALRNKEE------ELDQLIRK--RQME---LERLSESNTEHSYV----------------------------------
--------------------------------TYQ---------DIRGIKSFKE-QIVICIKAPQDTKLEVP--------
-------------DPGEKIQMLLKSTKG-EIDVFLCP--DPQD-------------------------------------
--------------HISPKKEPVEGDSGLLEST-----------------------------------------------
--------------------------------------------------------------------------------
------SVSDGSQR------------------------------------------------------------------
------------------------LS-GSQYEENRPLFMQTEDQMPSDEVD--SAFIDEDSFIALSPAMNPDDYLFSLDD
SEGISELFDMNATSLSGARTS-------
>Ciona_savignyi_E2F3
--------------------------------------------------MDNSRVFSTTTAREMFTNNLASISPHCSNK
TF---EFHASPSLEHTHQWLPGGHDLAGVSDISIMSVESQSNRTSNQVKRKLELP-------------------------
----------SHSPG-QSPYYMSESQLQQLHNQQLTN---------YNKPSSFKSPLKRGKSAMERKVLATNPPIR----
KRKNSSTNAAMAGSPS-------------------EKSRYDTSLGLL-TKRFIQLMKSSSDGILDLNHAAEILSVQ-KRR
IYDITNVLEG-IGLIEKRSKNNVQWVDA--------------------QKCDDEQVNEEEKR-------------ESELE
LASLRKQEE------QLDTLIRK--RQLE---LERLSESNNEYPFY----------------------------------
--------------------------------FSQLLD-----IYIRGIKSFKD-QIVICIKAPQDTKLEVP--------
-------------DPGEKIQMLLKSTKG-EIDVFLCP--DPHD-------------------------------------
--------------NMSPKKS--QSDS-CLGDT-----------------------------------------------
--------------------------------------------------------------------------------
------LEEDRSQR------------------------------------------------------------------
------------------------ISPNGKYEDTKPLLMQTDDCIPSDEVD--SAFIDEDSFIALSPSVNPDEYLFTLDD
SEGISELFDINSTSLSAPPSS-------
>Branchiostoma_floridae_E2F3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------KSPLEKTRYDTSLGLL-TKKFVGLLGSSPDGIVDLNQAAEVLNVQ-KRR
IYDITNVLEG-INLIKKKSKNHIEWR----------------------VQSTMEKDKERLN---SAIG--------LFKT
VDTEHIREN------LLDELIRH--SSTQ---LKHLTEDSENKKYPFQ--------------------------------
-----------------------------HGEHYCKCR-----NDIRSIKTFEE-QTVIAIKAPPETRLEVPDP------
--------------RES-IQIWLKSSKG-PIEVYLCPEE--QN-------------------------------------
--------------TEDAGSSSSDAASS----------------------------------------------------
---------------------------EGCSSTSG---------------SPCSVK------------------------
---GSELKTNEMA-------------------------------------------------------------------
------------------------RSLLPQTEDQDQEIQD--------------------FVALSPPLME-DDYLFSLSP
GEGISDLF-DAYDL--------------
>Saccoglossus_kowalevskii_E2F3
------------------------------------------------------------------------------MP
RGQPMQTVSRPAIPTLT--------ITKSTVANTTYGEVSR----GITIKGVTQ--------------------------
-------IQELEPIYTVKALQQHQEILSQVGCTPDLQ-TKVIKPTIGRPPQ--------------AKRKLDLD-----AT
AAMLDDGFKSPRGGRK----KPRPSPKGS-AQSPAERTRYDTSLGLL-TKKFVGLLRSAPEGVLDLNYAAEVLEVQ-KRR
IYDITNVLEG-INLIAKKAKNNIEWKG---------------------SSNSIASNGQEGSVCASSVD--------LNAE
IFDLEAKEN------RLDELIKS--CTLQ---LKMLTEDANNGK------------------------------------
--------------------------------YPL---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------
>Homo_sapiens_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE
IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNS-----------------------------------
-------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG----
LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS-------------------------------------
---------------PPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQ------------------------------
EASRPNSPQL-TPTA--VPGSAE---------VQGMAGPAAEITVSGGPGTDSKDSG-ELSSL------PLGPTTLDTRP
LQSSALLDSSSSSSSSSSSSSNS-NSS-----------------------------------------SSSGPNPSTSFE
PIKADPTGVLELP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPVLNL-------------
>Pan_troglodytes_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MAEA-PQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE
IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNS-----------------------------------
-------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG----
LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS-------------------------------------
---------------PPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQ------------------------------
EASRPNSPQL-TPTA--VPGSAE---------VQGMAGPAAEITVSGGPGTDSKDSG-ELSSL------PLGPTTLDTWP
LQSSALLDSSS------SSSSNS-NSS-----------------------------------------SSSGPNPSTSFE
PIKADPTGVLELP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDD
SEGVCDLFDVPVLNL-------------
>Mus_musculus_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE
IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNS-----------------------------------
-------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG----
LNGQK------------KYQIHLKSMSG-PIEVLLVNKEAWSS-------------------------------------
---------------PPVAVPVPPPDDLLQSPPAVSTPPPLPKPALAQPQ------------------------------
ESSPPSSPQLTTPTP--VLGSTQ---------VSEVACQTSEIAVSGSPGTENKDSG-EVSSL------PLGLTALDTRP
LQSSALLDSSSSSSSSSSSSSSSSS----------------------------------------------GPNPSTSFE
PIKADPTGVLDLP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPVLKL-------------
>Rattus_norvegicus_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE
IEELQQREQ------ELDQHKVW--VQQS---IRNVAED--VQNS-----------------------------------
-------------------------------CLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG----
LNGQK------------KYQIHLKSMSG-PIEVLLVNKEAWSS-------------------------------------
---------------PPVAVPVPPPDDLLQSPPAVSTPPPLPKPALAHPQ------------------------------
ETSRPSSPQITTPTP--VLGSTE---------VSDVAGQTAEIAVSGSPGTENKGSG-ELSSL------PLGLTALDTRP
LQSSALLDSSSSSSSSSSSSSSSSSSS--------------------------------------------GPNPSTSFE
PIKADPTGVLDLP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPVLKL-------------
>Canis_familiaris_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE
IEELQQREQ------ELDKHKVW--VQQS---IRNVTED--VQNSPH---------------------------------
-------------------------------TLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG----
LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS-------------------------------------
---------------PPVAVPVPPPEDLLQSPPAVSTPPPLPKPTLAQPH------------------------------
DTSRPSSPQLTTPTP--VTGITE---------AQGVPGPAAEIAVSGGPGTDSKDGG-ELGSL------PPGLAALDTRP
LQSSALLDSSSSSSSSSSSNSSSSG-----------------------------------------------PNPSTTCH
PVAPAPIEFLELP--------KELSEIFDPTRECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPVLNL-------------
>Myotis_lucifugus_E2F4
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
-MAEAGPQAPPP--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE
IEELQQREQ------ELDQHKVW--VQQS---IRNVTED--VQNSPH---------------------------------
-------------------------------TLAYVTH-----EDIC--RCFAG-DTLLAIRAPSGTSLEVPIPEG----
LNGQK------------KYQIHLKSVSG-PIEVLLVNKEAWSS-------------------------------------
---------------PPVAVPVPPPEDLLQSPSALSTPPPLPKPAVALPQ------------------------------
DASHPSSPQVTSTTTICVPAGVE---------AQGMAIPAAEIIVSGGPGSDSKDSG-ELSSL------SLGPAALDTRP
LQSSALLDSSSSSSSSSSSSSSSSS----------------------------------------------GPNPSTSFE
PIKVDPTGVLELP--------KELSEIFDPTPECMSSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPVLNL-------------
>Monodelphis_domestica_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------P--------------------PGTPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-ELK----------------AE
IEELQQREQ------ELDQHKVW--VQQS---IRNVTEDTFCLFSLTPA-------------------------------
-------------------------------TVAYVTH-----EDIC--KCFTG-DTLLAIRAPSGTSLEVPVPEG----
LNVQK------------KYQIHLRSATG-PIEVLLVNKDAWSS-------------------------------------
---------------PPVVVPVPPPEDLLQFQAAIPSPPQ-PRPAPSQHP------------------------------
ETSIPSSPCPSTPTS---TQDQS---------AIGQPTASPVAGSSSGPGADSKDAS-VLGTLN-----TASPAALDTRP
LQSSASLDSSST-----------------------------------------------------------LPNPSTSFE
PIKPDPTGILELP--------KELSEMFDPTRECMSSGLLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPVLNL-------------
>Gallus_gallus_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MAECGPQPPGAGGGGGG------GGGGGSGGAGAPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIAHKLI-ELK----------------AD
IEDLEQQEQ------ELEKQKMW--VQQS---IKNVTED--VQNN-----------------------------------
-------------------------------WLAYVTH-----EDIC--KCFTG-DTLLAIRAPSGTRLEVPIPEG----
PSRQK------------KYQIHLKSTSG-PIDVLLVNKDAWSS-------------------------------------
---------------PPVVLPVPPPEDLIQCQAVAPSKPQ--IPPLAHFQ------------------------------
EASVPSSTQPSTPTP---SSTQD---------HSPPEQKDT-STECSISVVESKSSSSDLDPLSNVSAPSGHTARLDTQL
LQSSASLDSSSVL-----------------------------------------------------------PSPSASFE
PIKPDPAGMLELP--------KELSEMFDPTRECMNSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPVLNL-------------
>Anolis_carolinensis_E2F4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
MAADSGAQPPG----------------------GGPSR-HEKSLGLL-TTKFVSLLQEAKDGVLDLKLAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIAHKLI-ELK----------------AE
IEDLEQRER------ELEQQKIW--VQQS---IKNVTDD--VQNS-----------------------------------
-------------------------------RLAYITD-----EDLC--KCFPG-DTLLAIRAPSGTQLEVPVPEG----
LNGQK------------KYQIHLKSTSG-PIDVLLVNKDAWSS-------------------------------------
---------------PPVVLPVPPPEDLIQCQLATPSKPH--RPALH---------------------------------
--SVPSRSQPSAPVP---SSTQD---------HVCATLKTAGATESDISITEPKSVG-ELDPLTPPAAPIILPAGLDTQP
LQSSASLDSGSVL-----------------------------------------------------------PSPSTSFQ
LIKPDPTEILELP--------KELSEMFEPDRECMNSELLEEL----------MSSEVFAPLLRLSPPPGDHDYIYNLDE
SEGVCDLFDVPILNL-------------
>Takifugu_rubripes_E2F4_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-LGAVGDSLQPQ----------------------TPSR-HEKSLGLL-TTKFVTLLQEAKDGVLDLKAAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-DLK----------------AE
LDDLALREH------ELDQQRVW--VQQS---IKNVTDD--SNNSPL---------------------------------
-------------------------------TLAYVKH-----EDLC--GAFKG-DTLLAIRAPIGTQLEVPIPESVGYI
PNGQR------------KYQIHLKSSTG-PIEVLLVNKDPSSA-------------------------------------
---------------SPVVLPVPPPDEILQSLP-TPALTPASQPSVSQVLK----------------------------S
AAAASVKPAPVAAAIPPVPST-------ESMMVPSILISSWSSDGTTVQVSDAPSSSPLAPAT--------ETPVAATQQ
LLSSASLDGSASS------------------------------------------------------------SASAVFE
PVKSDPSELLDFP--------KELSDMFDPTKEIS-GDLLEDL----------MSSEVFSPLLRLSPPPSDHDYIYNLDE
TEGLCDLFDVPILNL-------------
>Gasterosteus_aculeatus_E2F4_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-STQPVRLTLPQ----------------------TPSR-HEKSLGLL-TTKFVTLLQEAKDGVLDLKAAADTLAVRQKRR
IYDITNVLEG-IGLIEKKSKNSIQWK------GVGPGC----------NTREIADKLI-DLK----------------AE
LDDLALREN------ELDQQRVW--VQQS---IKNVTDD--SNNSP----------------------------------
--------------------------------YPSLQH-----EDLC--GAFKG-ETLLAIRAPIGTQLEVPIPESV--V
LNGQR------------KYQIRLKSSSG-AIEVLLVNKDPSSS-------------------------------------
---------------SPVVLPVPPPDDILQSLP-VPTPTSQPPTAVPQY-R----------------------------L
LSSFTSSFRPSVLQNCSSND-------------------------CKTRPGRNNSCS---SHR--------DNPSISTQQ
LQSSASLDGSASS------------------------------------------------------------SASAGFQ
PIKSDPSELLDFP--------KELSDMFDPTKEIISGDLLEDL----------MSSEVFSPLLRLSPPPSDHDYIYNLDE
TEGLCDLFDVPILNL-------------
>Homo_sapiens_E2F5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------MAAAEPASSGQQAPAGQGQGQRPPPQP
PQAQAPQPPPPPQLG----------------GAGGGSSRHEKSLGLL-TTKFVSLLQEAKDGVLDLKAAADTLAVRQKRR
IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-YLK----------------AE
IEDLELKER------ELDQQKLW--LQQS---IKNVMDDS-INN------------------------------------
-------------------------------RFSYVTH-----EDIC--NCFN-GDTLLAIQAPSGTQLEVPIPEM---G
QNGQK------------KYQINLKSHSG-PIHVLLINKESSSS-------------------------------------
---------------KPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQN------------------------------
-----------LPEQ---------------------------------HVSERSQA------------------------
LQQTSATDISSA--------------------------------------------------------------------
--------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD
NEGVCDLFDVQILNY-------------
>Gorilla_gorilla_E2F5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------MAAAEPASSGQQAPAGQGQGQRPPPQP
PQAQAPQPPPPPPLG----------------GAGGGSSRHEKSLGLL-TTKFVSLLQEAKDGVLDLKAAADTLAVRQKRR
IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-YLK----------------AE
IEDLELKER------ELDQQKLW--LQQS---IKNVMDDS-INNS-----------------------------------
-------------------------------TFSYVTH-----EDIC--NCFN-GDTLLAIQAPSGTQLEVPIPEM---G
QNGQK------------KYQINLKSHSG-PIHVLLINKESSSS-------------------------------------
---------------KPVVFPVPPPDDLTQPSSQSLTPVTPQKSSMATQN------------------------------
-----------LPEQ---------------------------------HVSERSQA------------------------
LQQTSATDISSA--------------------------------------------------------------------
--------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD
NEGVCDLFDVQILNY-------------
>Mus_musculus_E2F5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------MAAAEPTSSAQPTPQAQAQ-------P
PP---HGAPSSQPSA----------------ALAGGSSRHEKSLGLL-TTKFVSLLQEAQDGVLDLKAAADTLAVRQKRR
IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-CLK----------------AE
IEDLELKER------ELDQQKLW--LQQS---IKNVMEDS-INNR-----------------------------------
--------------------------------FSYVTH-----EDIC--NCFH-GDTLLAIQAPSGTQLEVPIPEM---G
QNGQK------------KYQINLKSHSG-PIHVLLINKESSSS-------------------------------------
---------------KPVVFPVPPPDDLTQPSSQSSTSVTPQKSTMAAQN------------------------------
-----------LPEQ---------------------------------HVSERSQT------------------------
FQQTPAAEVSS---------------------------------------------------------------------
--------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD
NEGVCDLFDVQILNY-------------
>Rattus_norvegicus_E2F5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------MAAAEPTSSAQPTPQAQAQ-------P
PPPPPHGAPSSHQSA----------------ALAGGSSRHEKSLGLL-TTKFVSLLQEAQDGVLDLKEAADTLAVRQKRR
IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVIDRLR-CLK----------------AE
IEDLELKER------ELDQQKLW--LQQS---IKNVMEDS-INNR-----------------------------------
--------------------------------FSYVTH-----EDIC--SCFN-GDTLLAIQAPSGTQLEVPIPEM---G
QNGQK------------KYQINLKSHSG-PIHVLLINKESNSS-------------------------------------
---------------KPVVFPVPPPDDLTQPSSQSSTSVTPPKSTMAAQN------------------------------
-----------LPEQ---------------------------------HVSERSQN------------------------
FQQTPATEISS---------------------------------------------------------------------
--------------------------------GSISGDIIDEL----------MSSDVFPLL-RLSPTPAD-DYNFNLDD
NEGVCDLFDVQILNY-------------
>Myotis_lucifugus_E2F5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------MAAAEPASSGQSAPQGQAQVQ------
-WAPPASPAPPPQLG----------------ARGGARGRRRGCGPRC-TRLFIRQLQGAGMGVPDAGEAADTLAVRQKRR
IYDITNVLEG-IDLIEKKSKNSIQW------KGVGAGC----------NTKEVLERLR-DLR----------------AE
VEDLDLKER------ELDQQKSW--LQQS---IRNVMDDT-INSRR----------------------------------
------------------------------RTFSYVTH-----EDIC--NCFH-GDTLLAIQAPAGTQLEVPLPEM---G
QNGQK---------