>Homo_sapiens_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MAEQQGRELEAECPVCWNP------------------------------------------------
-------FNNTFHTPKMLDCCHSFCVECLAHLSLVTPARRR---------------------------------------
LLCPLCRQPTVLASGQ-----PVTDLPTDTAMLAL---------------------------------------------
-------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPQVYTL--
----------DLGPQPGGQTG-----------------PPPDTASATVSTPILIPSHHSLRECFRNPQFRIFAYLM--AV
ILSVTLLLIFSIFWTKQFLWGVG---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Pan_troglodytes_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MAEQQGRELEAECPVCWNP------------------------------------------------
-------FNNTFHTPKMLDCCHSFCVECLAHLSLVTPARRC---------------------------------------
LLCPLCRQPTVLASGQ-----PVTDLPTDTAMLTL---------------------------------------------
-------------------------------------------LRLEPHHVILEGRQLCLKDQPKSRYFLRQPRVYTL--
----------DLGPQPGGQTG-----------------PPPDTASATVSTPILIPSHHSLRECFRNPQFRIFAYLM--AV
ILSVTLLLIFSIFWTKQFLWGVG---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Macaca_mulatta_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MAEQEGRELEAECPICWNP------------------------------------------------
-------FNNTFHTPKMLDCCHSFCVECLAHLSLVTPAQRR---------------------------------------
LLCPLCRQPTVLALGQ-----PVTDLPTDTAMLTL---------------------------------------------
-------------------------------------------LRLEPHHVILEGRQLCLKDQPKSRYFLRQPRVYTL--
----------DLGPQPGGQTG-----------------PPPDTASATVPMPIPIPSHYSPRECFRNPQFRIFAYLM--TV
ILSVTLLLIFSIFWTKQFLWGVG---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Mus_musculus_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MSEPQGQELRAECPVCWNP------------------------------------------------
-------FNNTFHTPKVLDCCHSFCVECLAHLSLVTPARRR---------------------------------------
LLCPLCRQPTVLASGQ-----PVTDLPTDTAMLTL---------------------------------------------
-------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTL--
----------DLGAEPGSQTG-----------------LPQDTAPDTR--PVPIPSHYSLRECVRNPHFRIFAYLM--AV
ILSVTLLLIFSIFWTKQFFWGMG---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Rattus_norvegicus_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MSEPQVQELKAECPVCWNP------------------------------------------------
-------FNNTFHTPKVLDCCHSFCVECLAHLSLVSPARRR---------------------------------------
LLCPLCRQTTVLASGQ-----PVTDLPTDTAMLTL---------------------------------------------
-------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTL--
----------DLGPEPGSQTG-----------------LPQDTAPDTR--PVPIPSHYSLRECVRNPHFRIFAYLM--AV
ILSVTLLLIFSIFWTKQLFWGMG---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Bos_taurus_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MAEQQGREP--ECPVCWNP------------------------------------------------
-------FNNTFHTPKVLDCCHSFCVECLAHISLVTPTRRR---------------------------------------
LLCPLCRHPTVLASGQ-----PVTDLPTDTAVLTL---------------------------------------------
-------------------------------------------LRLEPHHVILEGHQLCLKDQPKSRYFLRQPRVYTL--
----------DLGPEPASQAG-----------------QPQDVGPSTR--PVPIRSRYSLRECFRNPHFRIFAYMM--AV
ILCGTVLFIFSIFCTRRFFWGVG---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Anolis_carolinensis_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------MSCFTQIWRTEVPESPPPSPTSPVPAAP---------HEIPIPL
SPG-----------SPTDRPTSPIECSICFNT------------------------------------------------
-------YDNLFKTPKVLRCNHTFCLECLARLAAARPRSCL----ED--------------------------------E
LPCPFCRQITEIPLE------GPPGLQTSKDLMAT-LP------------------------------------------
------------------------------------------PEHQREKMIWMEGTKICCR-QSS-DPENADACISID--
----------IAPSKPEVPQLPP---------------ETFM-----------GRLTRCDM-CDDWKRVLLLSVLI--II
LFCIILWPLHCAMKTGNLRC------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Xenopus_tropicalis_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MADAVKLDPDWDCPVCWNP------------------------------------------------
-------YNPTSRTPKLLHCNHCFCLECLERLSQASPMR-----------------------------------------
IPCPLCRHPTVLPEGQ-----GVPALPTHSAILSQ---------------------------------------------
-------------------------------------------VRAEQPTP---RPFFCPKDSLKLPLFQRPPSIYTV--
----------SVGEEPG---------------------PPFNSQS-----PLTLPSTGPPWHCFRNPQLRMFSYLM--LV
IAGVTLFLIFSIFWTRKFIWGQR---------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Danio_rerio_RNF183_b
--------------------------------------------------------------------------------
----------------------------------------------------------------------MGDRRE----
-----KPQSSRKGSNAKPKLESKGSLNLGSSEQRQRADKPVRRSRSNDTENRRREGSRGRERDRRDEGRPQRGRSEEGRR
RGHNHEPGNRAWDKERPKDELQDTECIVCFCN------------------------------------------------
-------FDNVFKTPKLLSCGHTFCLECLARINVNSPEIKT---------------------------------------
LTCPICREVTEIRHGR-----DLPHLLNNEAIFRQ-LP------------------------------------------
------------------------------------------SEMQRALSVRFKRSKGKLVLKNPP-TNNSIKTTLNL--
----------PVLKKKEEQAGNN----------------AIGAIEEGLGQATMINVGRPPNRMRGRMRRVMYSSQC--YY
AVVAVIISITVALMMVGIFTFVVMPNLQRPITKPLQN--QTGSSAVQADSSP----------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Takifugu_rubripes_RNF183_a
--------------------------------------------------------------------------------
----------------------------------------------------------------------PGGSQS----
-----QSQQTRPAVNVKPKPTQK---EIRYSQTQWKKEKPAKVRRSRSSDSERVERGRRSNKERHHGERRRRGRSEETHR
PDRREN-RDEGSKAGPPPDDMEDTECAVCFCT------------------------------------------------
-------YDNVFKTPKLLACGHTFCLECLARINVTSAELKT---------------------------------------
LSCPICRELTKLPHGK-----DLPRLGNNLDIIDK-LP------------------------------------------
------------------------------------------PDMHRALSIRFQRSKGKLLLKNPPPTSPTKSNLLTL--
----------PVKSQGGP-VTPE---------------GNLDAMEQGIVPTTVVDVGRPPSRIRGRLRRVFRSDQC--YY
AVVGSIITITVVLMLVGLLAFVIIPKVPVFQSPTPAGNHTSGHTGASGGSSP----------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Tetraodon_nigroviridis_RNF183_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------ECSICYTT------------------------------------------------
-------YDNVFKTPKELDCTHTFCLECLSRLMALSPADQDSDHPLK--------------------------------H
ISCPLCRRTTTLPKE------GPPALTTNHEVLRK-LP------------------------------------------
------------------------------------------HHQQ----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Tetraodon_nigroviridis_RNF183_b
--------------------------------------------------------------------------------
----------------------------------------------------------------------QSQSQS----
-----QSQQPRPAANVKPKPPQK---EIRHSQTSWKKEKPAKARRSRSSDSE---RGRRRDSERHHGERRRRGRSEETQR
RDRGGG-GTERSRAGPPQDDIEDTECAVCFCT------------------------------------------------
-------YDNVFKTPKLLACGHTFCLECLARINVTSAELKT---------------------------------------
LSCPICREVTRLPHGQ-----DLPRLGNNLDIIDK-LP------------------------------------------
------------------------------------------PDMHRALSIRFKRSKGKLLLKNPPATSPTKASTLTL--
----------PVKSQGDAGVHPE---------------GSPGAMEQGMVSATVVDVGRPPSRIRGRMRRLFRSDQC--YY
AVVGSIITLTVLLMLVGLLAFVIIPKV-----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Oryzias_latipes_RNF183_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------MAKDDMAEV
ELPSTGAEPPGE--ASSAFPYEEYECKICYNY------------------------------------------------
-------FDLDRRAPKILECLHTFCEECLN-TLHLREERPW--------------------------------------R
ISCPVCRHRTPVPDY------RIQNLPNNTKVTEDFPLYIDSDPLPQ---------------------------------
------------------------------------------DALPPFPPPLH--PALVALRREEAS--GASSVSQAT--
----------PSTTVSTATTLSQ---------------DSVRYDSCQSCKRVALTTGCVCVIFSFLSMLVLLFMGL--IF
VHSHSIPPSPAGPICLSVASILAMFSVVVTWLICWLKYRPDHETGRASSTGNSRRNA-----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Ciona_savignyi_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MENRRTHIEASDVDLALEE------------------------------------------------
------------AGHCGLYHAWLILLMAVPNILVGAHMGSS---------------------------------------
VFEAMIPTHYCVTQQ-------ADDITTACNITWN---------------------------------------------
----------------------------------------------------PTNDALAVPEDLDGKHSPCHMYYYDN--
---------------------------------------------------------------VTDIDCKFWTLDK----
--NSTPTVEPGIRTCDHWIFD-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Drosophila_melanogaster_RNF183
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------MNNSPKDPYRGGGGGSGPQDGAGSTGVSINIESDDNDSTTAEHDYLL
PASSSSVTSGGGVGGGGVVSGGSTSTSVNLDH------------------------------------------------
-------QHVPTARSSSLSGGNVRHGNILSTFLARQRSYTPASNSSSP------------------------------VR
VTTQMNRRLQQSRSMGANTGGSLEEPSSAGAAGGPGASPG----------------------------------------
-----------------------------------------TAAGVRQMGFWRVNLNDVFSLSTASSTEALRSFISHSN-
--------FRYPPATTAAPAAPGP------------QPAANPVDNSHILLGQQQPSMPEPVSPLRYGRVSAVSGASSAGA
MGRSISLREGEMRHNHSLNGGRHNASAIGLNSNPAAFDEREANESQDLDESDGNVENGGGGGNPPEPAENNPEDEHLISD
DMVVQILSHFVRYLPLIFILFFKFLHDHLLGIVDLLVLQTVMYNVNRSVRNQVARLAQKNYAVMVR--------------
------------------------------------------------------------------------DTFLVAVV
VTVRLFLATSPPDPFGLIVPPSRKSVFIEVTALPFHTSSEGDSPTTSSEPIKTNMYKDTYKSLNVIPLGMLLYYIAVSDL
IIKLLTMLVKLIITMLPHHLMRLKVRARLYVLVEYISQFYRAMTPITQWLLFLYESYSGLEVVSGGLFSAMYLGAKIFEL
VERGKSLKKAIVTFRKNIDSERPPTKDELDAAGALCPICHDAFNTPTVLECGHIFCDECVQTWFKREQTCPMCRAKVSDD
PAWQDGSTTFFHQLY-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Homo_sapiens_RNF223
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------MSSGQQVWHTAVPPPRRSSSIASMPRSP---------SSAGSPR
SP----------GTPGSERVASPLECSICFSG------------------------------------------------
-------YDNIFKTPKELSCTHVFCLECLARLAAAQPVGRPG---GE--------------------------------A
VPCPFCRQPTAVPPA------GAPALCTSRQLQAR-MP------------------------------------------
------------------------------------------AHLRREEPVWLEGTKLCCQPLPTTPGR-EPGFVCVD--
----------VGLSKPAEP--PA---------------PARDPAPR------RGRLARCWARCRDWRRMALVSALL--LM
LFCVALWPVQCALKTGNLRCLPLPPRPPATS--TAASPLGPLTDN-----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Macaca_mulatta_RNF223
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------LSHSSETCRPASRCGTRPCPPIAGAAPQP---------RCPGPPA
RLAA------PGPTPGSEKVASPLECSICFSG------------------------------------------------
-------YDNIFKTPKELSCTHVFCLECLARLAAAQPVGRPG---GE--------------------------------A
VPCPFCRQPTTVPPA------GAPALRTSRQLQAR-MP------------------------------------------
------------------------------------------AHLRREEPVWLEGTKLCCQPLPTTPGH-KPSFVCVD--
----------VGLSKPAEPPAPA---------------QDPAPRR--------GRLARCWMRCRDWRRMALVSALL--LV
LFCVALWPVQCAIKTGNLRCLPRQPPSPSSTGGSPTGGLKGAAATG----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Bos_taurus_RNF223
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------MSSGPQVWHTTMPLTSRSSPTATVPRSP---------SSASSPR
SP----------GTPGSEKVASPLECSICFSG------------------------------------------------
-------YDNIFKTPKELSCTHVFCLECLARLAAAQPTGQPG---SE--------------------------------A
VPCPFCRQPTAVPAA------GAPALRTSRQLQAR-MP------------------------------------------
------------------------------------------AHLQQEEPVWLEGTKLCYYPSPSVPGPVEPGFMCVD--
----------IGPSKPPEPAVPV---------------PTPDPAHR------RGPLARCWARCRDWRRVALITALL--LV
LFCVVLWPVQCALKTGSLRCL---PRPPSTA--ATTSSLGSLAYN-----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Gallus_gallus_RNF223
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------MSCFTQLWHSSTPDPIVITSPVDSKRKAR--------SPTDKPG
SPN-----------PTSPKPASPVECSICFNT------------------------------------------------
-------YDNTFKTPKLLQCSHVFCLECVARLSKGLPPNHP----ED--------------------------------Q
LPCPFCRQLTSIPQE------GAPALETSKELLAT-LP------------------------------------------
------------------------------------------PELQQEKVLWMEGTKLCCR-QASDDPENPDSCISID--
----------VAMSKPESPEVPP---------------TGLV-----------GRLSRCDM-CDDWKRIVLLSALI--II
LFCIILWPVQCALKTGNLRCFTRPHGPQRP----FCAHTWMGALTSS---------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Xenopus_tropicalis_RNF223
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------SRLECSICFTK------------------------------------------------
-------YDNIFKTPKLLQCSHTLCLECVARLVAALPPEKQ----AE--------------------------------D
VLCPFCRQPTHIPDD------GAPALQTSQELLST-LP------------------------------------------
------------------------------------------AHLQHEEPVWIEGNKLCYKKPPETNPDQHDLCICVD--
----------IGLSKKDSPTEPR---------------QRR----------------GCFRGCSDWKRLLLIAFIV--AV
LFCILLWPVECILKTGSLRCTS-EPVPTRIPVVPAVVTHGPIDER-----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Gasterosteus_aculeatus_RNF223_a
--------------------------------------------------------------------------------
---------------------------------------MFPAPRSAAAALFHLTTPPDVPPPQQVPDSLPPPTHPSISN
MSEDREGRAAAPPPNVKPKLGQT---ERRSKEGTWKKEKPPKERRSRSTHSEREDERRGRERDRHRGGRSRRGRSEEARG
RDGRGS-ASG--RVKPPEDEVEDTECAVCFCS------------------------------------------------
-------YDNIFRTPKLLACGHTFCLECLARINVTSARLKT---------------------------------------
LSCPVCREPTELPHGR-----DLPRLGTNKDVLGR-LP------------------------------------------
------------------------------------------PDMRRVLSIRFKRSKGKLQLKNPPPAGRDKNSVRQP--
----------SKIQGGAVPAGGH---------------SDLSALE-----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Gasterosteus_aculeatus_RNF223_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------IELQSPEVDAPSADELECKICYSA------------------------------------------------
-------YNLAARRPKVLGCCHRLCAKCLAKILDLGESPPD--------------------------------------A
VACPFCRYVTGLPGQ------AVSGLPDDCNLAAALALQSRNQRNLHS--------R-----------------------
------------------------------Q-----------EATTELLLSPGLLSSLMGGGPPTTGSPNFVVITIME--
----------TPPPPMPLPASGED--LRRQPRGPRGGFRSSSLDSTASIAHRWTAWNCASQLCQTSARVLVWVLGL--LY
FS--SLPMGVYLLIMQRTTVGLLLVSLVPASLVVIMVYGFCQCVYHELWDCVPP--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Branchiostoma_floridae_RNF223
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MASSLLSQISEDFLKCQICHDT------------------------------------------------
-------FKR----PKVLSCLHTFCLQCLKSYLKKNPRVSIK-------------------------------------T
FLCPLCRQETATPPT------GADGLKDNFFVSNLLEA------------------------------------------
------------------------------------------LSTLKTFKVKGFVACGGCSRSASSRCMECEDFLCVHCH
G----------VHAKLKVTRDHT-------------VLSIRELSSEGGSAQIRAYTKATLCPVHEGETMRFYCETC--QK
PICRDCTVLDHSKPDHKYVYFKDALSSRKDEIQDLLTSCRGMVEGLEETKERLESEEGELRETKEGTLKDIEEWVAGLVL
DTQRKKEELKDQVETIYNEQLKELSAAKSRVEMTLNDIDSGCGFSEKVLDIGTDFEILSMRN------------------
--------------------------------------------------------------------------------
-------------EMAARLSDLTKMERPKVDQNRSGLIKFRPYGGIGELVKLGVGELDSRTVGELVVKFGGWGPQQGQFK
HPGGVAVSSAGHIIVADTGNHRIQV---FDSRGVFLRAFGFYGSADDAFSHPHDVAM-----TTDDRILVTDKGNKLVKL
F-------------------------TLEGKLIGKIGTGNLKEPTGVAVYKHGGVAVTDTRDVKTFTRTGVMSATCTSDD
PGYSHYLCTDDEGRCSKCSL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Homo_sapiens_RNF225
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------MPCPRPFWLRHSRAPQGSGPSSPGSLSAPRSPSR-GEDQEEEEEEE
GDGSPG-------SGPILPPASPVECLICVSS------------------------------------------------
-------FDGVFKLPKRLDCGHVFCLECLARLSLATAGGGN--------------------------------------A
VACPVCRAPTRLAPRR-----GLPALPTQSGLLPRDAR------------------------------------------
------------------------------------------APPSRQGSVRFDRRRGLLYLRPPPPPPGPRKARA----
-----------PPPPPPLRLGRP---------------LSRRLS----------LASPAWVFNAAVALAVLVAAGL--VV
SGVYIFFLIPHATSSGPPRPQLVALAPAPGFSWFPPRPPPGSPWAPAWTPRPTGP--DLDTALPGTAEDALEPEAGPEDP
AEAERTLDRRSDGTWGTEAGPGWAPWPRGARRLWGSQ-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Macaca_mulatta_RNF225
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------MPCPRPFWLRHSRAPQGSGPSPP---------SR------------
-DGSPG-------SSPILSPASPVECLICVSS------------------------------------------------
-------FDGVFKLPKRLDCGHVFCLECLARLSLATAGGGN--------------------------------------A
VACPVCRAPTRLAPRR-----GLPALPTQSGLL-----------------------------------------------
----------------------------------------------------------------------PRDARA----
-----------PPS----RQGS-----------------VRFVS----------LASPAWVFNAAVALAVLVAAGL--VV
SGVYIFFLIPHATSSGPARPQLVALAPAPGFSWFPPRPTPGVPWTPAWTPRPTGP--DLDTTLPGTAEDALEPQAGPEDP
VENEGTLDRPSDGTWGTEADPGWAP-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Mus_musculus_RNF225
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------MPCPRLPWLRRHRTSQGSGPSSPSTVSAPNSPSR--GEDEDAEEEE
GDGTPG-------SGPILPPTSPMECLICVSP------------------------------------------------
-------FDGIFKLPKRLDCGHVFCLECLARLSLATAGGGD--------------------------------------A
VACPMCRAPTRLAPRR-----GLPALPTQPGLLPRDAR------------------------------------------
------------------------------------------APLPRQGSVRFDRRRGLLYLRPPPPSPGPRKSRTVR--
----------APPPPPPLRLGRP---------------LSRRLS----------LSSPAWAFNAAVALAVLVAAGL--VV
SGVYIFFLIPHVTNSG-VRPQTVALAPENDF-WVSPRPTPVAPWTHAWTRRPTKPDLDLDDTLPEATKDTPELEEATKDP
VETQGIPDLPPDQTPKAEIDLNWNPKAQADGKKVQLQQ------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Rattus_norvegicus_RNF225
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------MPCPRLPWLRRHRTSQGSSPGSPSTLSAPNFPSR--GEDEDAEEEE
GDGTPG-------SGPILPPASPMECLICVSP------------------------------------------------
-------FDGIFKLPKRLDCGHVFCLECLARLSLATAGGGD--------------------------------------A
VACPMCRAPTRLAPRR-----GLPALPTQPGLLPCDAR------------------------------------------
------------------------------------------APLPRQGSVRFDRRRGLLYLRPPPPSPGPRKSRTVR--
----------APPPPPPLRLGRP---------------LSRRLS----------LSSPAWAFNAAVALAVLVAAGL--VV
SGVYIFFLIPHVTTSSPARPQIVALAPENGF-WVSPRPTPVAPWTHTWTRRPTKP--DLDDTLTETTKDTPEL-EATKGP
VEIQETPDLSPDQTPNAETDLSWDRKAWTDGKRVQLQQ------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Danio_rerio_RNF225_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------KVSSHPECSICFNT------------------------------------------------
-------YDNVFKTPKQLDCTHTFCLECLSRIMTTSMDPQNS-------------------------------------K
IPCPFCRQPTTIPKK------GPPALTTSQEVLCR-LP------------------------------------------
------------------------------------------IHQQHEEPVWLDGERLCYQRPIEMPGV-PAFCICVD--
----------IGASGHSGVSSSQ---------------TRPR--------------LSLMERMMDWKRLLIFIFLM--VL
LLGIVLWPLQCIVTTGSLRCSPQNMHMSTTTASTTTVTMLLLLGDE----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Takifugu_rubripes_RNF225_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---LKMKCAQTDIEE-DCPPPDEIECKICYQH------------------------------------------------
-------YNAYKRKPKILDCLHRVCTQCLNKILDVAEG-AG--------------------------------------F
ILCPFCRHQTPITDS------EVSALPDDANIMSRLAM--QEKSWSS---------------------------------
------------------------------------------DHTGEVLLTP---KSFSS-SSPSPDSSSCLVITMTE--
----------EQRDSEHAPRQN------------SAIYPEQSLESVSVGSDGHVDQYATSKLCHHVPRTLVWLLGF--LY
FG--SLPLGIYLLVLQKVTLGIVSVSLVPTSLTVCLVYEFCS-VCDNSVDCMYTL-------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Gasterosteus_aculeatus_RNF225_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----MSG-AQAEIEEKDSPPPEELECKICYQR------------------------------------------------
-------YNAHHRRPKVLDCLHRVCVRCLIKILDIADG-TD--------------------------------------F
ISCPFCRHQTEVSEY------EVSALPDDAIIMSRLAM--RDKSWSS---------------------------------
------------------------------------------DKNREVLLTP---TSFSS-SSPSRDSSNCLVITIME--
----------VQGDSQRSPTRDG----------SSDVFAEQSLDSVSMGSNGLADQDALSKFCNHVPRILVWLLGF--LY
FG--SLPLGIYLLVIQRVTLGIACVSLVPSSLTVCLVYGFCQCLCQGMCDCYS---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Oryzias_latipes_RNF225_a
--------------------------------------------------------------------------------
-----------------------------------------------------------------MNEGREAGGPP----
-----GGNDPPLAPNVKPKPNQN---VKNTKEEHRSKKKTVKVKRSRSTDSQRGERGRRRERER---ERGSRGRSEDTQR
RER---------RRKPPENDVEDTECSICFCS------------------------------------------------
-------YDNIFKTPKVLACGHTFCLECLARINVTSAELKN---------------------------------------
LPCPVCREVTELRHGR-----DLPRLDNNQEIIQK-LP------------------------------------------
------------------------------------------SQMQRARSIR----------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Oryzias_latipes_RNF225_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----MIGPQLEEVGDKDCPSPEELECKICYQR------------------------------------------------
-------YNAHNRKPKILDCLHRVCARCLLKILDVADG-GG--------------------------------------S
IPCPFCRHQTEISEY------QVSALPDDVNIMSHLE-----KSSSS---------------------------------
------------------------------------------DQNREVLLTP---QSFSS-SSPSRDSSNCLVITIME--
----------VQRDSGHSPSQNG----------SSDIYAEQSLDSVSIGSNGPADHDALTKLCNHVPRILVWLLGF--LY
FG--SLPLGIYLLVIQRVTLGIVCVSLVPSSLTVCLVYGFCQCLCQGMCDCSSRG-------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------
>Ciona_intestinalis_RNF225
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MAGA-KSLKNKLEDDLLTCPICCSL------------------------------------------------
-------YND----PRVLKCQHSFCHGCLKGSMKAAKSNGK--------------------------------------S
INCAVCRKPTPLAKK------GLADLPKNYVIIGLSQMVKEHKESGKSPVVAK-SSS-----------------------
------------------------------G-----------KNVGNVKQLVETFNKKSIVEKPSKKRDKNFNIEVPKAG
VVHDDENDDSSDLSTSASDSSGMT--EFTPTDDSESTSSGSDDSSSGSDDSDTDSESDSGSSDDEEPEHVPQRPTI--KS
SHGIKLGMKVFVFTAKGKPLPGTVRVLEKYKRKPPNQTQVYAGVQMEKEYKKLTTEDILDMDDSYLFNWLMDFDQPCVAV
RIDQCCPAKVIQRFNL----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------