>Homo_sapiens_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLPSRQT------------AIIVNPPPPEYINTKKNGR-----LTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK
LQLPDYYTIIKN--------PMDLNTIKKRLENKYYAKASECIEDFNTMFSN-CYLYNKPGDDIVLMAQALEKLFMQKLS
QMPQEEQVVG---VKERIKKGKAG-----------------------------------GTQQNIAVSSAKEKSSPSATE
KVFKQQEIP-------------------------------SVFPKTSISPLNVVQGASVNSSSQTAAQV-----------
--------------------------------------------------------------------------------
-----------------------TKGVKR-KADTTTPATSAVKASSEFSPTFT---------------------------
--------------------EKS-VALPPIKENM------PKNV----LPDSQQQ----------------YNVVKTVKV
TEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY
KYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKT------------------------DITETTGR------
---ENTNEASSEGN------------------SSDDSEDERVKRLAKLQEQ----------------------------L
KAVHQQLQVLSQVPFRKLNK-KKEKSKKEKKKEKVN--------------------------------------------
--------------------------------------------------------------------------------
-----NSNENPRKMCEQMRLKEKSKRNQ----------------------------------------------------
--------------------------------PKKRKQQFIGLKSED---------EDNAKPMNYDEKRQLSLNINKLPG
DKLGRVVHIIQSREP-----SLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKP-----------PAKKIMMSK
EELHSQKKQELEKRLLDVNNQLNSRKRQT----KSDKTQPS----------KAVENVSRLSE------------------
-------------------SSSSSS---------------SSS-ESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPS-
KENVKKMKN-----ECIPPE--------------GRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQEL
EHLQTVK-NISPLQILPPSGD-----SEQLSNG----------------------------ITVMHPSGDS---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------DTTMLESECQAPVQKDIKIKNADSWKS
LGKPVKPS--GVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------L
TVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
>Pan_troglodytes_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLPSRQT------------AIIVNPPPPEYINTKKNGR-----LTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK
LKLPDYYTIIKN--------PMDLNTIKKRLENKYYMKASECIEDFNTMFSN-CYLYNKPGDDIVLMAQALEKLFMQKLS
QMPQEEQVVG---VKERIKKG---------------------------------------TQQNIAVSSAKEKSSSSATE
KVFKQQEIP-------------------------------SVFSKTSISPLNVVQGASVNSGSQTAAQV-----------
--------------------------------------------------------------------------------
-----------------------TKGVKR-KADTTTPATSAVKASSEFSPTFT---------------------------
--------------------EKS-VTLPPIKENM------PKNV----LPDSQQQ----------------YNVVKTVKV
TEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY
KYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKT------------------------DITETTGR------
---ENTNEASSEGN------------------SSDDSEDERVKRLAKLQEQ----------------------------L
KAVHQQLQVLSQVPFRKLNK-KKEKSKKEKKKEKVN--------------------------------------------
--------------------------------------------------------------------------------
-----NSNENPRKMCEQMRLKEKSKRNQ----------------------------------------------------
--------------------------------PKKRKQQFIGLKSED---------EDNAKPMNYDEKRQLSLNINKLPG
DKLGRVVHIIQSREP-----SLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKP-----------PAKKIMMSK
EELHSQKKQELEKRLLDVNNQLNSRKRQT----KSDKTQPS----------KAVENVSRLSE------------------
-------------------SSSSSS---------------SSS-ESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPS-
KENVKKMKN-----ECILPE--------------GRTGITQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQEL
EHLQTVK-NISPLQILPPSGE-----SEQLSNG----------------------------ITVMHPSGDS---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------DTMMLESECQAPVQKDIKIKNADSWKS
LGKPVKPS--GVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRGSGNG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------L
TVEPFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
>Macaca_mulatta_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------PGDDIVLMAQALEKLFMQKLS
QMPQEEQVVG---GKERIKKG---------------------------------------TQQNIAVFSAKEKSSPNATE
KVFKQQAIP-------------------------------SVFPKTSVSPLNVAQGASVNSSSQTVAQV-----------
--------------------------------------------------------------------------------
-----------------------TKGVKR-KADTTTPATSVVKASSEFSPTFT---------------------------
--------------------EKS-VTLPPIKENM------PKNV----LPDSQQQ----------------YNVVKSVKV
TEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCY
KYNPPDHEVVTMARMLQDVFETHFSKIPVEPVESMPLCYIKT------------------------DITETTGR------
---ENTNEASSEGN------------------SSGDSEDERVQRLAKLQEQ----------------------------L
KAVHQQLQVLSQVPFRKLNK-KKEKSKKEKKKEKVN--------------------------------------------
--------------------------------------------------------------------------------
-----NSNENPRKMCEQMRLKEKSKRNQ----------------------------------------------------
--------------------------------PKKRKQQYIGQKSED---------EDNAKPMNYDEKRQLSLNINKLPG
DKLGRVVHIIQSREP-----SLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKP-----------PAKKIMMSK
EELHSQKKQELEKRLLDVNNQLNSRKRQT----KSEKTQPS----------KAVGSVSRLSE------------------
-------------------SSSSSS---------------SSS-ESESSSSDLSSSDSSGSESEMFPKFTEVKPNDSPS-
KENVKKMKN-----ECILPE--------------GRIGITQIECSVQDRTSANTTLVHQTTPSHVMPPNHHQLAFNYQEL
EHLQTVK-NISPLQILPPSGD-----SEQLSNG----------------------------ITVMHPSGDN---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------ATTMLESECQAPVQKDIKIKNADSWKS
LGKSVKPS--GVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKEPKVSQENQRDLGNG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------L
TVESFSNKIQNKCSGEEQKEHQQSLEAQDKSKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD
>Mus_musculus_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLPSRQ-------------TAIVNPPPPEYINTKKSGR-----LTNQLQFLQRVVLKALWKHGFSWPFQQPVDAVK
LKLPDYYTIIKT--------PMDLNTIKKRLENKYYEKASECIEDFNTMFSN-CYLYNKTGDDIVVMAQALEKLFMQKLS
QMPQEEQVVG---GKERIKKD---------------------------------------IQQKIAVSSAKEQIPSKAAE
NVFKRQEIP-------------------------------SGLPDISLSPLNMAQEAPPICDSQSLVQI-----------
--------------------------------------------------------------------------------
-----------------------TKGVKR-RADTTTPTTSIAKASSESPPTLR---------------------------
--------------------ETKPVNMP-VKENT------VKNV----LPDSQQQ----------------HKVLKTVKV
TEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADALGLHNYYDVVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCY
KYNPPDHEVVAMARTLQDVFELHFAKIPDEPIESMHACHLTT------------------------NSAQALSR------
---ESSSEASSGDA------------------SSEDSEDERVQHLAKLQEQ----------------------------L
NAVHQQLQVLSQVPLRKLKK-KNEKSKRAPKRKKVN--------------------------------------------
--------------------------------------------------------------------------------
-----NRDENPRKKPKQMKQKEKAKINQ----------------------------------------------------
--------------------------------PKKKKP---LLKSEE---------EDNAKPMNYDEKRQLSLDINKLPG
DKLGRIVHIIQSREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKP-----------QAKKVVRSK
EELHSEKKLELERRLLDVNNQLNCRKRQTKRPAKVEKPPPPPPPPPPPPPPPELASGSRLTD------------------
-------------------SSSSSGSGSGSSSSSSGSSSSSSSSGSASSSSDSSSSDSSDSEPEIFPKFTGVKQNDLPP-
-----------------------------------KENIKQIQSSVQDITSAEAPLAQQSTAPCGAPGKHSQQMLGCQVT
QHLQATE-NTASVQTQPLSGD-----CKRVLLG----------------------------PPVVH-TSAE---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------SLTVLEPECHAPAQKDIKIKNADSWKS
LGKPVKAS--SVLKSSDELFNQFRKAAIEKEVKARTQEQMRKHLEHNAKDPKVSQENQREPGSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------L
TLESLSSKVQDKSLEEDQSEQQPPSEAQDVSKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD
>Canis_familiaris_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLSSRQ-------------TAIVNPPPPEYLNTKKNGR-----LTNQLQYLQKIVLKALWKHSFSWPFQQPVDAVK
LKLP-------------------------------------------------------PGDDIVLMAQALEKLFRQKLS
QMPQEEQIVG---GKERVKKG---------------------------------------IQHNVTVPSVKEKQSPKALE
KVFKQQVIP-------------------------------SVFPETSMSPSNMAQGTPLNSTSQTVAQV-----------
--------------------------------------------------------------------------------
-----------------------TRGVKR-KADTTTPTAAVVKASGESSPTLT---------------------------
--------------------EQKSVKTPPLKENV------LKTV----FPDSQQQ----------------CKVVKNVKV
TEQLRHCSEILKEMLAKKHLSYAWPFYNPVDVHALGLHNYYDIVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCY
KYNPPDHEVVTMARMLQDVFEMHFAKIPDEPIESMPVCYIKT------------------------DTTKIPGR------
---ESSSEASSEDN------------------SSGDSEDERVQRLTKLQEQ----------------------------L
KAVHQQLQVLSQVPFHKLKK-KS-KSKREKKKEKIN--------------------------------------------
--------------------------------------------------------------------------------
-----SRDENPRKKFKQMKSKEKSKNNQ----------------------------------------------------
--------------------------------PKKRKQQVFTSKPED---------EDNAKPMNYDEKRQLSLDINKLPG
DKLGRVVHIIQSREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVAACLRKRPLKL-----------HGKKITKSK
EEFHSQKKQELEKRLLDVNNQLNSRKCQT----KSEKTQSS----------KAVGSGSRLSE------------------
-------------------SSSSST---------------SSSSETESSSSDSSSSDSSDSESEMFPKFTGVKQNDSP--
KELVKKMKN-----MCSMKR--------------GKTQVVYSGKCGNDKTSAKTTLVCQTSYSCETPPNHHQSALNHQEL
EHLQGVK-NISPLQIPPPSGD-----TEQHLNG----------------------------LTVTHQSDDN---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------DTRVLESECQVPVQKDIKIKNADSWKS
LGKPVKTS--GVLKSSDELFNQFRKAAIEKEVKARTQELIRKHMEQNTKEPKRVQENQRDLG------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------F
TQESFSNKMQNQYLGE-QKDHQQSSEAQDKYKLWLLKDRNLAREKEQERRRREAMAGTIDMTLQSDIMTMFENNFD
>Felis_catus_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLSSRQ-------------TAIVNPPPPEYINTKKNGR-----LTNQLQYLQKVVLKALWRHNFSWPFQQPVDAVK
LKLPDYYTIIKT--------PMDLNTIKKRLEHKYYMKASECIEDFNIMFSN-CYLYNKPGDDIVLMAQALEKLFRQKLS
QMPQEEQIIG---GKERIKKG---------------------------------------IQHNVAVPSGKEKQSPKALD
KVFKQQVIP-------------------------------SVFPKTSISPSNVSQGTLFNTTSQTVAQV-----------
--------------------------------------------------------------------------------
-----------------------TRGVKR-KADTTTPTTSVVKASGESSPTLA---------------------------
--------------------EKKSVKMPPMKENV------LKTV----LPDSQQL----------------CKVIKSVEV
TEQLRHCSEILKEMLAKKHLSYAWPFYNPVDVNALGLHNYYDIVKNPMDLGTIKGKMDNQEYKDAYEFAADVRLMFMNCY
KYNPPDHEVVTMARTLQDVFEMHFAKIPDEPVESMPVCYIKT------------------------DTTEVHDR------
---ESRSEASSEDN------------------SSGDSEDERVQRLAKLQEQ----------------------------L
KAVHQQLQVLSQVPFRKLKK-KN-KSKREKKKEKVN--------------------------------------------
--------------------------------------------------------------------------------
-----NRDENPRKKFKQMKLKEKSKSNQ----------------------------------------------------
--------------------------------PKKRKQQVLALKPED---------DANAKPMNYDEKRQLSLDINKLPG
DKLGRVVHIIQSREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVAACLRKRPLKP-----------HGKKIMKSR
EEFHSQKKQELEKRLLEVNNRLNCRKRQP----KSEKTQSS----------KAVGSGSRLSE------------------
-------------------SSSSSSS----------SSSSSSSSETESSSSDSGSSDSSDSESEMFPKFTEAKQNDSP--
KEQVK------------------------------------IQSSVQDQASAKTTLFCQTSYSCETPADHHQLAFNHQEL
EHLHSVK-NISSLQILPPSGD-----CEQHLNG----------------------------LTMMHQSGDN---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------DTTVLESEGPVPVQKDIKIKNAESWKS
LGKPVKTS--GVLKSSDELFNQFRKAAIEKEVKARTQELIQKHVEQNTKETKVLQENQRDLG------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------C
IQQSFQIKCKTSALEK--------------------SRKNISSLWKLKINTNSCFSKTVI----------------
>Monodelphis_domestica_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLSSRQ-------------MAIVNPPPPEYINAKKNGR-----LTNQLQYLQKVVLKALWRHSFSWPFQQPVDAAK
LKLPDYYSIIKK--------PMDLSTIKKRLEHKYYVKSSECVEDLKTMFTN-CYLYNKPGDDIVLMAQALEKLFMQKMS
QMPSEEQVIG---GKERKRKG--------------------------------------TQPSSGVS-TIKEKPSPKASE
MIVKQQMIPS------------------------------SVCPQTSLSPLHMAKAAPLSCTTQAVTQV-----------
--------------------------------------------------------------------------------
-----------------------KRGVKR-KADTTTPTTSIVTASSESSPTLV---------------------------
--------------------EHKSAKIPLLKEKV------VKNI----VPDSQQQ----------------YKVVKSIKL
TEQLKYCNEILKEMFAKKHLAYAWPFYKPVDVTALGLHNYYDVVKSPMDLGTIKKKMDNQEYKDAHEFAADVRLMFMNCY
KYNPPDHEVVTMARTLQDVFEMQFAKIPDEPIERMPICYIKK------------------------DITKAYCR------
---ESSSDASSEDN------------------SSEESPDERVQHLAKLQEQ----------------------------L
KAVHQQLQVLSQVPYHKLKK-KNERSKREKRKEKKKFI------------------------------------------
--------------------------------------------------------------------------------
-----NKDESQRKNFKQIKLKKKLKSSQ----------------------------------------------------
--------------------------------PKKAKQQILTYKSED---------EDNAKPMNYDEKRQLSLDINKLPG
DKLGRVVHIIESREP-----SLRNSNPDEIEIDFETLKASTLRELEKYVMACLRKRPRKF-----------HAKKIMKSK
EELHSQKKQELEKRLLDVSNRLNSRKRQT----KSEKTQLP----------KAAGGATRLSE------------------
-------------------SSSSSGG-------------GSSSSGSGSSSSDSSSSDSSDSESETFPILTGIRQSGSPSK
EKMKTLSSCRI---LNQDLLI-------------PKKLEEPQQLQILQSLPPAQISISPSLPEIISSVDVTSLWQNAPDM
LTFEAFTPILSVSEQTSFSGDGKNECTSIVNAGKSTLLITTMWEGINSKTVKKEESASEQPVAAAFHQTAL---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------GLNVLEPELHLPTKKDIKIKNVDSWTN
LGKTVTTS--VLSKSSDDLFRQFRKAAMEKEVKTRTQEQIRKQLGQDPKEPKTHPDKHRHFD------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---NNPNKIRNECYPEDQKPHPAPLEVQDPR---LIKDRNLARKKEQERRRREAMASTIDMNLQSDIMMTFEENLD
>Ornithorhynchus_anatinus_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLPSRQ--------------TIVNPPPPEYINTKKNGR-----ITNQLQYLQKVVIKAIWKHSFSWPFQQPVDAVK
LRLPDYYRIIKN--------PMDLSTIKKRLEYKYYVKASECVEDFNTMFTN-CYLYNKPGDDIVLMAQALEKVFLQKVA
QMPQEEEVIGR--SKEGKRKG--------------------------------------TEPSSTAAPTIKGKLPSKTSE
TVGKQKVMT--------------------------------LCFQADDSPLQVVQAASQTSANQSVTQA-----------
--------------------------------------------------------------------------------
-----------------------KKGVKR-KADTTTPTTSVVTESSESSPSFT---------------------------
--------------------EQKCAKMLPTKEKV------TKNV----LPDSQQL----------------CKTVKNIKL
TEQLKHCNEILKELFSKKHLSYAWPFYKPVDVTALGLHNYYDVVKNPMDLGTIKKKMNNQNYKDAHEFAADVRLMFMNCY
KYNPPDHEIVGMARTLQDVFEMQFAKIPDEPSDSVPLYYIK---------------------------TEALKR------
---ESSSDASSEED------------------SSEDSEDERVQHLTKLQEQ----------------------------V
RLGFCRMPFC--ISY-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Gallus_gallus_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSLPSLRR------------SLITNPPPPEYINNRNSGC-----QTNQLQYLQRVVMKAMWRHNFSWPFHQPVDAAA
LNLPDYYSIIKK--------PMDLSTIKKRLEHNYYTKSAECIDDFKTMFLN-CYIYNKPGDDIVFMAQELEKVFMQKIA
QMPPEE-ILIP--DKGKRKEKLSE-----------------------------------ETQHPNSGTSSKQSTRQKQAE
S-GEQPTAIT------------------------------QELQKATLPPLSAAQLTALMPAAIPIAKT-----------
--------------------------------------------------------------------------------
-----------------------KKGVKR-KADTTTPTTSILTTSSESSATCN---------------------------
--------------------KRKTVKACKGENECMIPKKILKKG----LPDSQQS----------------PRVLKKTQL
SKQLKYCKEILKEMFSKKHSAYARPFLRSADVVSFSLGEKKGITKCPTDLGTIKKKMDNFEYRDIQEFATDVRLMFMNCY
KRNSPDHEVVAMAKKLQDVFETHFAKIPDEPATSILLPQHTR------------------------EITKAYSS------
---DSSSDDSSEEK------------------SSEDFEKERTVYLAKLQEQ----------------------------L
KAVHQQLQALTRASLPRLKR-KKEKAKREKGENKEKAK------------------------------------------
--------------------------------------------------------------------------------
-----ASLIRKKKDLKHKKSKKKQSSNIQS--------------------------------------------------
--------------------------------KKTIQQVLLAHKSED---------DDGAKPMNYDEKRQLSLSINKLPG
DKLGKVVHIIQSREP-----SLRNSSPDEIEIDFETLKASTLRELEKYVATCLRKRPRKQ-----------HAKKAMKSK
QQLLSERKQELEKRLLDVNGQLNPKKENFKCNSAVESSAES-----------SIG-PSRLSE------------------
-------------------SSNGSSS------------SDSGSN----TSSASSSSDSSDSES----VMETCSEQNGIRQ
NCLTSLEQPK----RMSYSAV-------------LQVQPSSITSSLQNHGSPEPQLLSPTVLQKLKPVQSRS----LKSA
EQNAKSPSGIKHLPKSPLNMVIEQGGNKHLKN----------------------------LIEVKGRCSTP---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------NGTKTLETKSQSFPERAAGIKNIDSWVS
LCKMMTLP--APIKSSAESFKHFRKVALQKAAGQAQEKERKYNEQSWHLSATSFREEEK-YDSP----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------S
LHSFISSIN-TSLDCKPRKEENMSKQLPEAQQHPLVQDRNLARKMEQERRRREAMACTIDMNLQSDIMATFEENLE
>Xenopus_tropicalis_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---MSMSSRHLH-----------SSIVNPPPPEYINRKKTGR-----LTNQLQYLEKVVLKALWRHHFSWPFQQPVDAAK
LNLPDYYQIIKN--------PMDLSTIRKRLEYNYYSKALDCIQDFNTMFTN-CYIYNKPGDDIVVMSQELEKVFMEKIA
EMPHEEIELSV--VGNRGVKS--R-----------------------------------IKISAVAAEVCKKKMVSQKMH
RRTFPCPVIA------------------------------MMPKRTTLVPLSVIRSSTSSHSASSVSKV-----------
--------------------------------------------------------------------------------
-----------------------NKGIKR-KADTTTPAVSLIATSCESSPTLS---------------------------
--------------------EPKPNKILSGTEKTR-SAETSAVD----LPDSQHH----------------IHFIKSNQI
CEQLKHCNNILNEMMSKKHAEYAWPFYK--TVIPTSLLDCSDAIKHPMDLATIRDKMENGLYKDTQDFASDVRLMFMNSY
KYNPPDNEVVNMARKMQDVFEGMFAKIPDDPLATQS----MV------------------------ERYKTSTE------
---ESSSSSSSEQS------------------SSSDSEDERAQHLALLQEQ----------------------------L
RAVQEQLKALTETPIFSKIQPKSAVGVYDKYKQWVK--------------------------------------------
--------------------------------------------------------------------------------
------CIEPMGKLLKRKKNYDAKKKKL----------------------------------------------------
------------------------------------------HVSDE---------EEDVKPMSYDEKRQLSLDINKLPG
EKLGRIVHIIQSREP-----SLKDSNPNEIEIDFETLKQSTLRHLEKYVMVCLRKRPKKP-----------SSIKSLKSK
EQLNKEKKQELEKRLRDVSGQLSSAKKPK-----IQGFLYP---------MQSIGGPSRLSE------------------
-------------------SSTSSS------------------ASDVSNSSDSSSSDSSDSESATFPKNILAKKQTSTNY
EVPLLLYYG-------CFVNK-------------PRTSIPQNGLCIGSQSLAYTTISTIVHPTPMALMPLHPGSTNYTSL
QLLLKYG-LHVPLIIENPLGN-----SVLFENY----------------------------LEVLHPSQIE---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------QTFAIKEECLKPKYKNAKVKTSFCWEV
FSKSLATTH-VTIKSSSNSFQQFRKAAIAKEERERALKAQELRRLEDSKAG-----MQEKLSPS----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------L
PMETKVHEMQAQTIDEATKGEPTCNPVHEGITE---EERNLARMREQERRRREAMAGTIDMYLQSDIMATFEEHLC
>Hydra_magnipapillata_BRDT
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------MASNVLNFH
HINNASNNKNTNLTFTGVDPANIKKPPLIIPSELSRPTNIQR-ITQKKAQVKAYPKNIKLEKLAVYSSCKAAVDACSCSG
WKNPNPTKSIEQQQQQHGLWTTECRTCKHLLSDHVSHLQEETEEQMNFLMSMVVDIENLFMCVHKETDSDNKQVYFYLFK
LLRKSIHQITKPTVEGPLGKPP---------------------------------------FENPNIEMAVKSFVAYKFT
NENPVECQIMN-----------------------------ELARIFVRCLNHWKLETPTARKQRLETVSLLN--------
-----------------------------------------------------------------------NKVNILDN-
---------ELFESNTNADISSYKVDYTRWLCFSHVPLFCDSLQKYDVTSIFG---------------------------
-------------------KKFLRSVFCLMKQQLLDKFSAEKEK----LPADTRIK----------------VLEHFPRF
LSLFEEEIKSEFSPIWNDDCSRINPIINPIETNTSSSQLFNDLTQTSIQINENTECKQNLLISSVEPSSTKAVTNPIKVE
PVTSPSKVTSNISLIKSEKSSESIAPKETLTENKPDSKSSVTTLP------------------TETIASLAKAP------
TTITSITTASSKSITPLN--------------LPEVSSSEILKRKSNIVETP---------------------------V
TKKMKLLSPIGDVPMEILARVIETITDPSKMVGPQGGFYP--------------------SQTARDEAAR----------
--------------------------------------------------------------------------------
------SEERRGLIEFHVIGNSLTKKPSRQ------------------TTIWLIGLQN----------------------
--------------------------VFSYQLPRMPKEYITRLVFDP---------KHRTLALIKDGRPIGGVCFRMFPT
QNFTEIVFCAVSSNEQVKG-YGTHMMNHLKDYHTQNGILNFLTYADEYAIGYFKKQGFSKDIKLAKCEYTGYIKEYEGAT
LMHCSLNPKIPYREFSLVIKKQKEIVRQLIKEKQEEIKKVYPG------LTCFKNGVSEIPIS-----------------
-------------------SIPGIEETG--------------WKQIQKNGKDILLNATAHHGALLNVLNAVKNHASAWPF
LKPVPRNEVP--------------------------DYYDIIKYPMDLQTMEERLEKKYYTLKKLFVADMSRIFSNCRTY
NGPDTEYYKCAGVVERYFLTKLKEYYDDSTTIEIKEEDVS----------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Homo_sapiens_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSVTSAHQVPAVS
SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP-----------
------------------------------------------------------------------------LLAVTAAP
----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------MPPGLAKSS------
SE-SSSEESSSESSSEEEEEEDEE-DEEEEESESSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGAD---------
--------------------------------------------------------------------------------
------EDDKGPRAPRPPQPKKS-KKAS-------------------GSGGG-SAALGPSGFGPS-GGSGTKLQAGVQWR
DLGLLQPPLLGFKRFSCLSLPSSQDYRLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-NEKTESS----------SAQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Pan_troglodytes_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSVTSAHQVPAVS
SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP-----------
------------------------------------------------------------------------LLAVTAAP
----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------MPPGLAKSS------
SE-SSSEESSSESSSEEEEEEDE--DEEEEDSESSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGAE---------
--------------------------------------------------------------------------------
------EDDKGPRAPRPPQPKKS-KKAS-------------------GSGGG-SAALGPSGFGPS-GGSGT---------
--------------------------KLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-NEKTESS----------SAQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Macaca_mulatta_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSVTSAHQVPAVS
SVSHAALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP-----------
------------------------------------------------------------------------LLAVTAAP
----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------MPPGLAKSS------
SE-SSSEESSSESSSEEEEEEDEDDEEEEEESESSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGAD---------
--------------------------------------------------------------------------------
------EDDKGPRAPRPPQPKKS-KKAS-------------------GSGGG-SAALGPSGFGPS-GGSGTKLGTGVQWH
HLGSWQPPLLGIKRFCLSLPNSWDYRLAPPSPANFSPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKV-NEKTESS----------SAQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Mus_musculus_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPH-KLPGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALQLAPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS
SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP-----------
------------------------------------------------------------------------LLAVSAAP
----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLTKSS------
SE-SSSEESSSESSSEEEEEEEE--DEDEEESESSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRIGID---------
--------------------------------------------------------------------------------
------EDDKGPRAPRPPQPKKS-KKAG-------------------GGGSN-ATTLSHPGFGTS-GGSSN---------
--------------------------KLPKKSQKTAPPVL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIRKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESS-----------AQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Rattus_norvegicus_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPH-KLPGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALQLAPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS
SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP-----------
------------------------------------------------------------------------LLAVSAAP
----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------
SE-SSSEESSSESSSEEEEEEDE--EDEEEESESSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRIGID---------
--------------------------------------------------------------------------------
------EDDKGPRAPRPLQPKKS-KKAG-------------------GGGSN-ATTLSHPGFGTS-AGSSN---------
--------------------------KLPKKAQKTAPPVL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIRKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESS-----------AQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Canis_familiaris_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPHSKLPGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS
SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPQ-----------
------------------------------------------------------------------------LLAVSAAP
----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGS-LEAKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------
SE-SSSEESSSESSSEEDEEEDEEEEEEEEESESSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGVD---------
--------------------------------------------------------------------------------
------EDDKGSRAPRPSQPKKS-KKAS-------------------GSGGGSAATLGPPGFGPS-GGSGT---------
--------------------------KLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESS----------STQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Felis_catus_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAALQGSITSAHQVPAVS
SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP-----------
------------------------------------------------------------------------LLAVSAAP
----------------PAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGS-LEPKAARLPPMRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------
SE-SSSEESSSESSSEEEEEEDEEDEEEEEESESSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGVD---------
--------------------------------------------------------------------------------
------EEDKGTRAPRPSQPKKS-KKAS-------------------GSGGGSAATLGPPGFGPS-GGSGT---------
--------------------------KLPKKATKTAPPAL-PTGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKTESSS---------SAQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Loxodonta_africana_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPHNKLSGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALQLTPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWAASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
SMPQEEQELVVTIPKNSHKKGA---------------------------------------KLAAFQGSITSAHQVPAVS
SVSHTALYTPPP----------------------------EIPTTVLNIPHPSVISSPLLKSLHSAGPP-----------
------------------------------------------------------------------------LLAVSAAP
----------------SAQPLAKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGA-LEPKAARLPPVRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTA-----------------------LPPGLAKSS------
SE-SSSEESSSESSCE-----------------SSDSEEERAHRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKS--------------------------EKHRGRAGVD---------
--------------------------------------------------------------------------------
------EDDKGPRASRPPQPKKS-KKAS-------------------GSGSA--AALGPPGFGPS-GGT-----------
--------------------------KLPKKATKTAPPAL-PAGYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKT-SEKTESS----------VAQQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Monodelphis_domestica_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MLQNVTPHSKLPGEGNAGLLGLGPEAAAPGKRIR
KPSLLYEGFESPTMASVPALHLPPAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWLASECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
LMPSEEQELVVTIPKNSHKKGA---------------------------------------KLAALQSSLTNAHQVPAVS
SLSHTPLYSPSP----------------------------EIPTTVLNIPHGSVISSPLLKSLHSAGTP-----------
------------------------------------------------------------------------LLAVSAAP
----------------TAQPLTKKKGVKR-KADTTTPTPTAILAPGSPASP-----------------------------
---------------PGGGPEPKAARLPPTRRESGRPIKPPR----KDLPDSQQQ----------------HQSSKKGKL
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPASTV-----------------------LPPGLAKSS------
SE-SSSEESSSESSSEEEEEEEE--EEEEEETESSDSEEERANRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--PKRKREKKEKKKKRKA--------------------------EKHRGRAGMD---------
--------------------------------------------------------------------------------
------EDDKGPRLPRPPPPKKSSKKSG-------------------GGGGSGPGAAGPPGFGLP-GSGAT---------
--------------------------RPPKKAMKTAPPPP-AAAYDS-------EEEEESRPMSYDEKRQLSLDINKLPG
EKLGRVVHIIQAREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPY---------TIKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSTKKPPKKA-SEKVESA------------QQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Gallus_gallus_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MASVPALQTPQAN--PPPPEVSNPKKPGR-----VTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKRRLENNYYWGAAECMQDFNTMFTN-CYIYNKPTDDIVLMAQTLEKIFLQKVA
QMPPEEQEIVVPVAKNSHKKGA---------------------------------------SRAAG---LTAAQQVPAVS
SVSHTAVYTPSP----------------------------DIATTIVNIPHPSVISAPLLKSLHSTAP------------
-------------------------------------------------------------------------AVLTAPA
----------------PTQPVAKKKGVKR-KADTTTPTTTAIIATSGESSP-----------------------------
---------------SATLLEAKAAKIP-ARRESGRPIKPPK----KDLPDSQQ-----------------HQTSKKGKL
SEQLKYCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHEIIKHPMDLSTIKRKMENRDYHDAQEFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFSYAKMPDEPQDASPPSVSAP-----------------------LLGALSKSS------
SEESSSDEDDEDEDDEDDDEDESSSESSSESEESSDSEEERANRLAELQEQ----------------------------L
RAVHEQLAALSQGPVSK--PKKKREK---KKKKKS--------------------------EKHKGRGGDE---------
--------------------------------------------------------------------------------
------ES-----RARQAQLRKA-KKGG-------------------GGGSG--------------GGSSK---------
---------------------------NSKKAAKAALPPP-PALYDS-------EEEEESKPMTYDEKRQLSLDINKLPG
EKLGRVVHIIQSREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYS-------ETMKKPVGKTK
EELALEKKRELEKRLQDVSGQLNSAKKPPKKA-NEKPESA------------QQVAVSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Xenopus_tropicalis_BRD2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------MHLKDISISCRPPLDLNHGMMGQSIEG-TPGKRIR
KPSLLYEDFEGPNMTSSVFHQLPQTN--PPPPEFSNSKKPGR-----STNQLQYLHKVVMKSLWKHQFSWPFRQPVDAVK
LGLPDYHKIIKQ--------PMDMGTIKKRLENNYYWSALECMQDFNTMFTN-CYIYNKPTDDIVLMAQSLEKMFLQKVA
QMPQEEQEIPNTASKIKNVKIS---------------------------------------KTSGPTGGVTTAHQVPAVS
--SQSSLYPSSP----------------------------EVPTTMLSLAHSSIISNPVLKSMPSSQAV-----------
------------------------------------------------------------------------LSVLPGAT
------------------QPVAKKKGVKR-KADTTTPTTTAIIATSGDLSP-----------------------------
---------------LQA-SETKPAKIP-ARRESGRPIKPPK----KDLPDSQQ-----------------HQTSKKGKL
SEQLKYCNGILKELLSKKHAAYAWPFYKPVDVSALGLHDYYDIIKHPMDLSTIKKKMDNREFKDAQEFAAAVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLVVNPPSTSSQ-----------------------LPPSDSKSS------
SE--SSSESSSESSDDSE--------------SSDDSEEERANRLAELQEQ----------------------------L
RAVHEQLAALSQGPISK--HDEWRSSKSKPSQAKK--------------------------SSKKSG---G---------
--------------------------------------------------------------------------------
------GIATSSTQPAPKLTRHAYSKSSFLCR-------------LRGTQETDGVKLHPPGGRTFRKRMKS---------
----------------------------TKKTFKSVPPAP-SVLYDS-------EEEEESKPMTYDEKRQLSLDINKLPG
EKLGRVVHIIQSREP-----SLRDSNPEEIEIDFETLKPSTLRELERYVMSCLRKKPRKPYT---------LKKPVGKTK
EEIALEKKRELEKRLQDVSGQLNSAKKPPKKS-HDKAESA------------QQVSVTRL--------------------
-------------------SASSSSS-----------------DSDSSSSSTSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Takifugu_rubripes_BRD2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------GLLGVS--AMDQGSATAGKRIR
KPSLLYEGFESPGMP--PVNQMTHPG--PPQPPVKDPSRQGR-----MTNQLQFLQKVLLKSLWRHHFAWPFHEPVDAVK
LNLPDYHKIIKT--------PMDMGTIKKRLENNYYRSASECMQDFNTMFTN-CYIYNKPTDDIVLMAQSLEKAFLQKVA
QMPQDELELPPPPPRMKSGKPG---------------------------------------KKGRVSGGVTTAHQVPAVS
---QSVYSPPTP----------------------------DTPDSILPTPPQTHLLKSLPHSF-STAQT-----------
------------------------------------------------------------------------APTITGLP
----------------PTQPTAKKKGVKR-KADTTTPTTVAMPIMNTMGVS---MGS-----------------------
-------------------MMSSKASVGERRGVSGRPIKPPK----KDLPDSMLP----------------PPVR-RSKL
SPQLRYCNGVLKELLSKKHAGYAWPFYKPVDASSLGLHDYHDIIKQPMDLSTIKRKMDNREYLDSQQFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFCFAKMPDEPPAPPSSSSSSS-----------------------SSSSSSSES------
DLSSESEDSESS--------------------PSSDSEEERANRLAELQEQ----------------------------L
KAVHEQLTALSQGPIIKPKKKKEKKDKKKKKKVEK--------------------------EKHRRIEDQ----------
--------------------------------------------------------------------------------
--------------PKPPKITKAPKSKST-----------------RAAGCPVLPIKKAPSKKNSKSNIGTTEWSI----
-FAFERAFLKMNKQFLSFSSPRSKKTGMMFSMPQTVHDPM-VSHFDS-------DEEE-TAPMSYDEKRQLSLDINKLPG
EKLGRVVYIIQSREP-----SLRDTNPEEIEIDFETLKPSTLRELERYVMTCLRKKPRKPY---------ASKNMAGKSR
EELALEKQLELERRLMDVSGQLNSGKKPPKTK---PEKP-A---------AEPHTQPSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSDSDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Tetraodon_nigroviridis_BRD2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------QVGVEGGLMGVS--TMDQGSATAGKRIR
KPSLLYEGFESPGMP--PVNQMSHPG--PPQPPVKDPSRQGR-----MTNQLQFLQKVLLKSLWRHHFAWPFHEPVDAVK
LNLPDYHKIIKT--------PMDMGTIKKRLENNYYRSASECMQDFNTMFTN-CYIYNKPTDDIVLMAQSLEKAFLQKVA
QMPQDELELPPPPPRMKTGKPG---------------------------------------KKGRVSGGVTTAHQVPAVS
---QSVYSPPTP----------------------------ETPDSLLSTPPQTHLMKSLPHSF-SAAPT-----------
------------------------------------------------------------------------TPTMTGLP
----------------PTQPTAKKKGVKR-KADTTTPTTVAMPIMNTMGVS---MGMGGGHGSPLTLTSLGVDHNSSLGM
SQGLAPGMGLSMGMGCGAGMMSTKASVGERRGVSGRPIKPPK----KDLPDSMLP----------------PPVR-RSKL
SPQLRYCNGVLKELLSKKHAGYAWPFYKPVDASSLGLHDYHDIIKQPMDLSTIKRKMDNREYLDSQQFAADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFCFAKMPDEPPAPP------------------------------------TES------
DLSSESEDSESS--------------------PSSDSEEERANRLAELQEQ----------------------------L
KAVHEQLTALSQGPIIK---------------LEK--------------------------EKHRRIEDQ----------
--------------------------------------------------------------------------------
--------------PKPPKIAKAPKSKST-----------------RAAGCPVLPMKKAPSKKNSKNNL-----------
----------------FLSSSRSKKSGMMFSMPQTVHDPM-VSHFDS-------DEEE-TAPMSYDEKRQLSLDINKLPG
EKLGRVVYIIQSREP-----SLRDTNPEEIEIDFETLKPSTLRELERYVMTCLRKKPRKPY---------ASKNMAGKSR
EELALEKQLELERRLMDVSGQLNSGKKPPKTK---PEKP-A---------AEPHTQPSRL--------------------
-------------------SASTSDS-----------------DS-----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------
>Oryzias_latipes_BRD2_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------SHTGYEIGHTGV---MMDQS--AAGKRIR
KPSLLYEDFESPGMP--AISQMAPSG--PPQPPVRDPSRHGR-----MTNQLQFLQKVVLKSLWRHHFAWPFHEPVDAAK
LNLPDYHKIIKT--------PMDMGTIRKRLENNYYRSASECMQDFNAMFTN-CYIYNKPTDDIVLMAQSLEKAFLQKVA
QMPQEEIELPPPVPRSKQSK---------------------------------------------ISGGVTTAHQVPAVS
---QSVYSPPTP----------------------------ETPDSILSTPPQTILTKCSSITL-QPEQT-----------
------------------------------------------------------------------------IPAITGPP
----------------PTQPTAKKKGVKR-KADTTTPTTMAMPIMSTLGVTGIGLGMVGGHDSPLTLTSLGMDHSSSLGM
NQAISISQGMGMGMGGGTMMLGAKATSGSRRGVSGRPIKPPK----KDLPDSILP----------------TPVR-RSKL
SPQLRYCSGVLKELLSKKHAAYAWPFYKPVDAVSLGLHDYHEIIKFPMDLSTIKRKMDGREYREAQQFSADVRLMFSNCY
KYNPPDHDVVAMARKLQDVFEFCFAKMPDEAPAPPSSTSSSS-----------------------SSSSS-SES------
ELSSDGEESESS--------------------PSSDSEEERANRLAELQEQ----------------------------L
KAVHEQLTALSQGPIVKPKKKKEKKDKKKKKRVEK--------------------------ERHRRIEDDL---------
--------------------------------------------------------------------------------
---------TPIRPPKAPKMTKTSKTKR--------------------MDCPVIPMKKTQSKKNSKSKS-----------
-----------------------KKAAITFNMP--HHDPL-VGHFDS-------DEEEDTAPMSYDEKRQLSLDINKLPG
EKLGRVVYIIQSREP-----SLRDTNPEEIEIDFETLKPSTLRELERYVMTCLRKKPRKPY--------VSTKNSAGKSR
EELALEKQMELERRLMDVSGQLNSGKKPAKNK---PDKP-A---------SDVHTQPSRL--------------------
-------------------SASSSSS-----------------DS-SSSSSSSSSSDTSESDSG----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------