>Homo_sapiens_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS
PTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRA----ADDGEG-------------------------IVGAAMPDSGP-
----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM
G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP
LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV
VDMRLREGAA----PGAARPTAPN------AQTPSHLGAT--------------------LPVGQP--VGGDPE------
-------VRKQMPPPPPCPAG-----RELFDDPSYVNVQNLDKARQAV---GGA-----GPPNPAINGSAPRDLFDMK--
----------------PFEDALRVP-----------------------PPPQS--------VSMAEQLRGEPWFHGKLSR
REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL
--------------
>Gorilla_gorilla_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS
PTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRA----ADDGEG-------------------------IVGAAMPDSGP-
----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM
G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP
LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV
VDMRLREGAA----PGAARPTAPS------AQTPSHLGAT--------------------LPVGQP--VGGDPE------
-------VRKQMPPPPPCPAG-----RELFDDPSYVNVQNLDKARQAV---GGA-----GPPNPAVNGSAPRDLFDMK--
----------------PFEDALRVP-----------------------PPPQS--------VSMAEQLRGEPWFHGKLSR
REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL
--------------
>Macaca_mulatta_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS
PTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRA----ADDGEG-------------------------IVGAAMPDSGP-
----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM
G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP
LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV
VDMRLREGAA----PGAARSTAPS------AQTPSHLGAT--------------------LPVGQP--VGGDPE------
-------VRKQMPPPPPCPAG-----RELFDDPSYVNVQNLDKVRQAV---GGA-----GLPNPAVNGSAPRDLFDMK--
----------------PFEDALRVP-----------------------PPPQS--------VSMAEQLRGEPWFHGKLSR
REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL
--------------
>Mus_musculus_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS
PTTLCSFFPRMSNLKLANPAGGRLGPKGEPGKA----AEDGEG-------------------------SAGAALRDSGL-
----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM
G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP
LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV
VDMRLREGA--------ARPTLPS------AQMSSHLGAT--------------------LPIGQH--AAGDHE------
-------VRKQMLPPPPCP-G-----RELFDDPSYVNIQNLDKARQAG---GGA-----GPPNPSLNGSAPRDLFDMK--
----------------PFEDALRVP-----------------------PPPQS--------MSMAEQLQGEPWFHGKLSR
REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVDRKV
--------------
>Canis_familiaris_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDES
PTTLCSFFPRMSNLKLANPAG-------EPGRA----SKDGEG-------------------------TGGAAVLDSAP-
----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM
G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP
LSAILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV
VDMRLREAAP----LGAVRPTPHV------VQTPSHLGAT--------------------LPVGQP--VGGDPE------
-------IRKQMPPPPPCP-G-----KELFDDPSYVNVQNLDRARQAG---GGA-----GPPNPAINGSVPRDLFDMK--
----------------PFEDALRVP-----------------------PPPQA--------VAMAEQLRGEPWFHGKLSR
REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHVDNHLPIISAGSE----LCLQQPVERKL
--------------
>Myotis_lucifugus_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLPPKPKYNPLRNESLSSLEEGAS--GSSPPE---------------ELPSPSASSLGPILPP----QAGDDS
PTTLCSFFPRMSNLKLANPAGARPGPKGEPGRV----AEDGEG-------------------------VAGAAVPDSGP-
----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM
G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ASRRRKPCSRP
LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV
VDMRLREGAP----QGPARPTLPS------AQNPSHLGAT--------------------LPVGQP--AGGDPE------
-------VHKQMPPLPPCPAG-----REIFDDPSYVNIQNLDKARQAG---GGA-----GPPNLAVNGSAPRDLFDMK--
----------------PFEDALRVP-----------------------PPPQS--------VAMAEQLRGEPWFHGKLNR
REAEALLQLNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNHLPIISAGSE----LCLQQPVERKL
--------------
>Pteropus_vampyrus_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLPPKPKYNPLRNESLSSLEEGAS--GSTPPE---------------ELPSPSASSLGPILPP----LPGDDS
PTTLCSFFPRMSNLKLANPAGGRLGPKAEPGRA----AEDGEG-------------------------TTGAAVPDSGP-
----------------LPLLQDMNKLSGGGGRRTR------------VEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVM
G-----PGVSYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCEAV---PGAKG-ATRRRKPCSRP
LSSILG-RSNLKFAGMPITLTVSTSSLNLMAADCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LRNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------PPDHQYYNDFPGKEPPLGGV
VDMRLREGAA----PGATRPTPPS------AQPPTQLGAT--------------------LPVGQP--VGGDPE------
-------VRKQMPPPPPCPAG-----RELFDDPSYVNVQHLDKARHAG---AGA-----GPPGLAVNGGAPRDLFDMK--
----------------PFEDALRAP-----------------------PPPHS--------VAMAEQLRGEPWFHGKLSR
REAEALLQLDGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQSGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SHHMDNHLPIISAGSE----LCLQQPVTRRP
--------------
>Xenopus_tropicalis_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLLP-KTKYNHLRNESVSSVEEALA--AGPLSP--------SVEIMVSLPSSASSSSLAPMLPLAELSSESEES
PTTLCSFFPKMANLKLSNPANLLNLRSFSSSMGGKESASPGEQ----------------------GDTPNEGSSPESGRT
F---------------TVFSQDMNKLSCG--RKSR------------VEGGQLAGDEWTRHGSFVNKPTRGWLHPDDKVM
G-----PGVPYLVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISLVCDAV---PGAKG-AMRRRKTCGRS
LNSILG-KSNLKFAGMPITLTVSTSSLNLMASDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECPEGLAQDVIST-------IGQAFELRFKQY-------------LKNPP----------------------
------------------KLVTPHDRM----------AGFDGSAWDEEEEE---------LPDHAYYNDFPGKEPPIGGV
VDMRLRDGVA----PA------VP------RQSPNHMGAT--------------------LPVGQV--SGAEQD------
-------SRKPQPTVQVPCSRPPN-RPDLFDDPSYVNVQNLEKSRQP--LRQQT-----ARDPMGTNAVGTTTNFPVA--
----------------PVEPFEDAL-----------------------PSAQ-------AVVSMEDQLKRESWYHGKMNR
KEAERLLKVNGD----------------------------------FLVRESTTTPGQ---------YVLTG-LQCGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----LCLQQPVERRQ
--------------
>Danio_rerio_SHC1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------MEYVDMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDIVVS
T-----SGVSYTVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISVVCEAV---PGAKG-AQRRRKPSSRC
LSSILG-KSNLQFAGMTITLTVSTSSLNLMAIDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECSEGLAQEVIST-------IGQAFELRFKQY-------------LKNPP----------------------
------------------KVVTPHDRM----------APFDGSAWEEEEED------LAPPPEVPYYNNFPGKQPPPGGL
VDMRTRPGHS----TGP------------------------------------------TLPYGQP----SQND------
-------IHKQPLPPLPVGVKDGG----LFDDPSYVNVD---KPRLPA--------------SAAANGNAHRDAFDMK--
----------------PFDAALVVS-----------------------GAV--------ALP-LAEQLQNEPWFHGPLSR
RQAERLLTKDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----VCLQQPVDRKA
--------------
>Takifugu_rubripes_SHC1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------MELAPKTKYTHFRSESLSSTDETNSNPSSVPPSSPVS----PLTPSPGMPSSLSSSSLTPILPPCS-PHPAENS
PTTLCSFFPRMGSLRLGVSATLLPSFKTASRPQNTRAPVESSGDDQSRA------------RPSPPVHHPLPPLT-----
---------------------DMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVS
T-----SGVSYTVRYMG-------CVEVLQSMRALD--FSTRTQ---VTREAIAVVCEAV---PGAKG-AQRRRKPSSRC
LSSILG-KSNLQFAGMTISLTVSTSSLNLLACDCK-QIIAN----HHMQSISFASGGD-----PETAEYVAYVAK--DPV
NQRACHILECSEGLAQEVIST-------IGQAFELRFKQY-------------LKNPP----------------------
------------------KLVTPHDRM----------APFDGSAWEEEDEE------PPPPPDVPYYNNFPGKQPPPGGL
IDMRTRPGAT----LVR---SMHI------SPTPIEETET--------------------IPYGQP----GQND------
-------IHKQPLPPLPAGAKEGG----LFDDPSYVNVD---KPRPR----------------VASNGNMHRDAFDMK--
----------------PFDDALGVS-----------------------GHSGTS-SASAAPP-LVQQLQCEAWFHGGLSR
KEAERLLTRDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----VCLKQPVERRA
--------------
>Tetraodon_nigroviridis_SHC1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------MELSPKTKYTHFRSESLSSTDETNSNLSSFPPSSPVT----PLTPSPGVPSSHSSSSLTPILPPCS-PRPAENS
PTTLCSFFPRMGSIRLGVSATLLPSLKIASRPQNTQAPAESSGEDRSSS------------SS-----------------
-------------------LQDMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDSVVS
T-----TGVSYTVRYMG-------CVEVLQSMRALD--FSTRTQ---VTREAISVVCEAV---PGAKG-AQRRRKPSSRC
LSSILG-KSNLQFAGMTISLTISTSSLNLLACDCK-QIIAN----HHMQSISFASGGD-----PETAEYVAYVAK--DPV
NQRACHILECSEGFAQEVIST-------IGQAFELRFKQY-------------LKNPP----------------------
------------------KLVTPHDRM----------APFDGSAWEEEDEE------TAPPPDVPYYNNFPGKQPPPGGL
IDMRTRPGAT----LEHN--KWKL------SNANVNGSFFSVAPC--------------LQPYGQP----GQND------
-------IHKQPLPPLPAGAKEGG----LFDDPSYVNVD---KPRPP----------------AASNGNMHRDAFDMK--
----------------PFDDALGVS-----------------------GHGGPS-SASAAPP-LVQQLQCEAWFHGGLSR
KEAERLLTRDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNRLPIISAGSE----VCLKQPVERRA
--------------
>Gasterosteus_aculeatus_SHC1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------MELVPKTKYTHFRSESLSSTDETNSDPSPLPPSSPAT----PLTPSPGLPPSLSSSSLAPILPPSS-PRQAENS
PTTLCSFFPRMGSLRLGVSATLLP------------------GGDRSSS------------GSSPPLHRPTAPLTAPSPP
P---------------RPTLQDMNRLGGAS-RKARSEGAARKA---RVEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVT
T-----AGVSYSVRYMG-------CVEVLQSMRALD--FNTRTQ---VTREAISVVCEAV---PGAKG-AQRRRKPSSRC
MTSILG-KSNLQFAGMTISLTISTSSLNLLASDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NQRACHILECSEGLAQEVIST-------IGQAFELRFKQY-------------LKNPP----------------------
------------------KLVTPHDRM----------APFDGSAWEEEEEDDNAAAAAAPPPDVPYYNNFPGKQPPPGGL
VDMRSRPGAT----LPR--EAALM------SNATFAQKGCR-LAE--------------LLPYGQP----GQND------
-------IHKQPLPPLPVGAKEGGR--ELFDDPSYVNVD---KPRHP----------------VAANGNAHRDAFDMK--
----------------PFDDALGVS-----------------------GPGGAS-SSTAAPPPLVQQLQCEAWFHGSLSR
REAERLLTRDGD----------------------------------FLVRESGTTAGQ---------YVLTG-QQGGQPK
HLLLVD--------PEGV----VRTKDHRFESVSHLI------------SYHMDNSLPIVSAGSE----VCLQQPVERRA
--------------
>Oryzias_latipes_SHC1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------LVPKTKYTHFRSESLSSNDDTNSNPSSFPPSSPAT----PLTPSPGIPSSLSSSSLTPILPPTS-PRPAENS
PTTLCSFFPRMSSLRLGVTATLLPGLKASSRSQPSQLAVESSGDDRSNS------------SSSPPLHQPAPLLTAPSPP
P---------------RPPLQDMNRLGGAS-RRAR------------VEGGQLGGDEWTRHGSFVNKPTRGWLHSDSVVS
T-----TGVSYTVTYMG-------CVEVLQSMRALD--FNTRTQ---VTREAIAVVCEAV---PGAKG-A-RRRKPSSRC
LTSILG-KSNLQFAGMPISLTISTSSLNLLASDCK-QIIAN----HHMQSISFASGGD-----PDTAEYVAYVAK--DPV
NHRACHILECTEGLAQEVIST-------IGQAFELRFKQY-------------LKTPP----------------------
------------------KLVTPHDRM----------APFDGSAWDEEDDE------IAPPPEVPYYNNFPGKQPPPGGI
IDMRTRSGAT----LVRRHPLMHT------TQHIRIQRGLQHRDD--------------KPLYGQQ----GQND------
-------IHKQPLPPLPG-AKEGTR--ELFDDPSYVNVD---KPRPP----------------LAANGNANRDAFDMRKL
DGKRKKKLLEPNIIEEPLDDALGVS-----------------------GTS--------APP-MVQQLQNEIWFHGSLTR
REAERLLTRDGD----------------------------------FLVRESGTTPGQ---------YVLTG-QQGGQPK
HLLLVD--------PEGV----VRTKDHRFGSVSHLI------------SYHLDNRLPIVSAGSE----VYLQQPVERRA
--------------
>Ciona_intestinalis_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------MRRNKKLVEGDQTNEWR------------------------KSGSFVNKPQRGWLHPDSSVM
G-----PGVVYSVQYLG-------CVEVRQSMRTLD--FDMRTL---ATKEAIWRVLASTGMSPLPPAANRSGRKKPPKD
VTRILGERPNLKFSQSFINLTISTASLTLVVSNTG-QFIAN----HQMQSISFASGGD-----PDTIDYVAYVAK--DPI
NSRACHVLKCTDGLAQDVINT-------IGQAFELRFKEY-------------LKNPP----------------------
------------------KAVTPPDRTEP-------LFHDGKSRWGDDEPE--------------YYNEIPGKLAPESGL
KRLDDGSKID--------------------EGAVVYPNHHNSQE---------------YINNGMQSECSAPTP------
----------TLSTPTPRRTP------RNFEDHNYVNTCVMPHGQEPT-----------------NQKRPSVDAFDMR--
----------------PFANTLNPP---------------------------------ATPTSATNALQSKPWFHGHVTR
KEAEQLLSHDGD----------------------------------FLVRESTTTKGQ---------FVLSG-VQDGQYK
HLLLVD--------PNGV----VRTKDRQFDSVSHLI------------SFHRDNTLPIVSSGSV----LLLRQPVTRQI
ER------------
>Branchiostoma_floridae_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------MVAT---TTWAGITGFPLTF------------KRKATWEV
LSTPGG-------DGVSPCTTSAHAFLSDMTAARS----------SSASPVSLESSLG-----KETQDYVAYVAK--DXV
NSRACHVLHCPGGLAQDVITT-------IGQAFELRFKDF-------------LKNPP----------------------
------------------KAVSAPDRL-------------EDPIFEEGESAWG--------DDPEYYNEIPGKLPPTGGM
PPPLPAGPPPG-HYQAPSNLQASDGVYSSVKDAPSRPGPTYDNKASADN--------LIDFTAETPTAPVYDNPLHEPAG
RGPPVSHGNDLPPEAAQPRSE-----VSLFDDPTYDNRRIENRPMHPDPMGAQQP--PQQPPQRPPLPLPAQDPFNMG--
----------------PFDAGLQQDP-----------------------------------ASPPHPLYQEEWFHGPMTR
KQAEELLEEDGD----------------------------------FLVRESERKYDIT-GP-----VVLTCLCLCAGER
KYNITG--------PVVLTCLCLCAGERKYDITGPVVLTCLCLCAGER-KYDITGPVVLTACWRQSQ-TPATGGPTGHKL
E-------------
>Apis_mellifera_SHC1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------MATGG--SS----------------------------------FISKPARGWLHPDHLVS
K-----EGITYTVKYIG-------CLEVYTSMKSLD--FETRSC---VAKECINRVCEAAG--LKSAD---KKRRVDRKV
LRAIAD-KPRMEHTGATINLTISSCSLALTNIENG-HIIAK----HEMPRISFASGGD-----TEILDFVAYVAK--NMQ
EWRACYVLECGGGLAQDVIST-------IGQAFELRFKEF-------------LTKPAS---------------------
------------------LHPILNGIR---------------------------------EADRDYYNDLPGKVPPDIGP
PPVPPLPTSA----STLPNLKHHH------SVQNHISRSNIQNSGL-------------HDTFSISSDRHHQQW------
--------AETGNLIDLNSDGTST-NFNIPPEHNYVNDSVIAASRENQRDQTSLF----DVFDMQPFSSAISDMNKLSP-
-------------------------------------------------------------HSQKQQLKQEIWFHGSVSR
AEAESMLTRDGD----------------------------------FLVRESQGSPGQ---------YVLTG-MNNNTPK
HLLLID--------PEGV----VRTKDRVFDSVSHLV------------NHHCDNVLPIISADSV----LVLRYPIPRRT
NN------------
>Homo_sapiens_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------MTQGPGGRAPPAPPAPPEPEA
PTTFCALLPRMPQWKFAAPGGFLGRGPAAAR---------AAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCP
L-----------------PALSRCRGAGSRGSRGGRGAAGSG--------DAAAAAEWIRKGSFIHKPAHGWLHPDARVL
G-----PGVSYVVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA
LASVLG-KSNLRFAGMSISIHISTDGLSLSVPATR-QVIAN----HHMPSISFASGGD-----TDMTDYVAYVAK--DPI
NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP----------------------
------------------KVALPPERL---------AG-PEESAWGDEEDS----------LEHNYYNSIPGKEPPLGGL
VDSRLALTQ-----PCALTALD----------QGPSPSLR--------------------DACSLPWDVGSTG-------
----TAPPGDGYVQADAR--G-----PPDHEEHLYVNTQGLDAPE--------------------PEDSPKKDLFDMR--
----------------PFEDALKLHECSVAAGV-------TAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSR
RAAERMLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK
HLLLVD--------PEGV----VRTKDVLFESISHLI------------DHHLQNGQPIVAAESE----LHLRGVVSREP
--------------
>Pan_troglodytes_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------YMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA
LASVLG-KSNLRFAGMSISIHISTDGLSLSVPATR-QVIAN----HHMPSISFASGGD-----TDMTDYVAYVAK--DPI
NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP----------------------
------------------KVTLPPERL---------AG-PEESAWGDEEDS----------LEHNYYNSIPGKEPPLGGL
VDSRLALTQ-----PCALTALD----------QGPSPSLR--------------------DACSLPWDVGSTG-------
----TAPPGDGYVQADAR--G-----PPGHEEHLYVNTQGLDAPE--------------------PEDSPKKDLFDMR--
----------------PFEDALKLHECSVAAGV-------TAAPT-VEDQWPSPPTR-----------------------
-------RSDGD----------------------------------FHVRESVTNPRL---------YVLTG-MHAGQPK
RLLVLD--------TEGV--------------------------------------------------------------
--------------
>Macaca_mulatta_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------QYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA
LASVLG-KSNLRFAGMSISIHISTDGLSLSVPATR-QVIAN----HHMPSISFASGGD-----TDMTDYVAYVAK--DPI
NQRACHILECCEGLAQSVIST-------VGQAFELRFKQY-------------LHSPP----------------------
------------------KVALPPESL---------EMNPQRQAGGWDSNSG---------LPAPSKSSSCGGLAPLGPA
CATRRRLSS-----QPTLDTSD----------EGPSASLR--------------------DARSLPWDVGSTG-------
----AAPPGDGYVQADAR--G-----PPDLEEHLYVNTQGLDAPE--------------------PEDSPKKDLFDMR--
----------------PFEDALKLHECSVAAGM-------TAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSR
RAAERMLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK
HLLLVD--------PEGV----VRTKDVLFESISHLI------------DHHLQNGQPIVAAESE----LHLRGVVSREP
--------------
>Mus_musculus_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------MTQGPGGRAAPE------PEA
PTTFCALLPRMPQWKFAAPGSFLGRGPAATR---------VAG--------VAEAQPEPGVPALAAVLGACEPRCAAPCP
L-----------------PALGRCRGSGTRGARVTPD----------------VADEWVRKGGFIHKPAHGWLHPDARVL
G-----PGVSYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA
LASILG-KSNLRFAGMSISVNISVDGLNLSVPATR-QIIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI
NQRACHILECCEGLAQSVIST-------VGQAFELRFKQY-------------LHSPP----------------------
------------------KAVVPPERL---------TG-LEELAWGDDDAA----------ADHNYYNSIPGKEPPLGGL
VDSRLAVTQ-----PCALATLGG-------LGQGMTPVWR--------------------DARGLPWDMGPSG-------
----AAPPGDGYVQADAR--G-----PHDYEEHLYVNTQGLDAVEL---EDTAE-------APLQFEDSPKKDLFDMR--
----------------PFEDALKLHACSVAAGI-------TAASPPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSR
RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK
HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLKNGLPIVAAESE----LHLRGVVSREP
--------------
>Canis_familiaris_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------MTQGPGGRTPPAPPAPPEPEA
PTTFCALLPRMPEWKFAAPAGFLGRGPAAARTAGGAGGAGGAGGAGGADPQPEEAAPGGVPALAAAVLGACEPRCAAPCP
L-----------------PALSRCRAAGARGPRGARGGAGPP--------DAAAAAEWIRKGSFIHKPAHGWLHPDARVL
G-----PGVSYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA
LASILG-KSNLRFAGMSIAVSISTDGLNLSVPATR-QIIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI
NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP----------------------
------------------RVAVPPERL---------TR-PEESAWGDEDEA-----------DHNYYNSIPGKEPPPGGL
VDSRLALAQ-----PGAL---GA-------LGQGAAPARR--------------------DARSLPWDLGPSG-------
----AGPPGDGYVQADAR--G-----PRDYEDHLYVNTQGLDAPE-----------------PPQAEDSPKKDLFDMR--
----------------PFEDALKLHECSAGAGT-------AVAPLPVEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSR
RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK
HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLQNGQPIVAAESE----LHLRGVVKREP
--------------
>Felis_catus_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------YMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGIRG--SWKKKAPNKA
LASILG-KTNLRFAGMSIAVSISTDGLNLSVPATR-QVIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI
NQRACHILECCEGLAQSIIST-------VGQAFELRFKQY-------------LHSPP----------------------
------------------RVVLPPERL---------TR-PEESAWGDEEET-----------EHNYYNSIPGKEPPLGGL
VDSRLALTQ-----PCAV---GA-------LGQGVSPARR--------------------DTRSLPWDLGPSG-------
----NSPPGDGYVQADAR--G-----PRDYEDHLYVNTQGLDAPE-----------------PLQPEDSPKKDLFDMR--
----------------PFEDALKLHECSAGAGA-------AVAPLPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSR
RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK
HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLQNGQPIVAAESE----LHLRGVVKREP
--------------
>Pteropus_vampyrus_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------YMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLHEAV---PGVRG--SWKKKAPNKA
LASILG-KSNLRFAGMSIAVSISTDGLNLSVPATR-QIIAN----HHMQSISFASGGD-----TDMTDYVAYVAK--DPI
NQRACHILECCEGLAQSVIST-------VGQAFELRFKQY-------------LHSPP----------------------
------------------KAVAPLERL---------TG-LEESAWGDEEDT-----------DHNYYNSVPGKEPPLGGL
VDSRLALTQ-----PCAL---GG-------LGQGASPVRR--------------------DARGLQWEPGSSG-------
----TASAGDGYVQADAR--G-----PRDYEDHLYVNTQGLDAPE-----------------SLPPEDSPKKDLFDMR--
----------------PFEDALKLHECSVAAGT-------AAAPLPSEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSR
RAAEKLLRADGD----------------------------------FLVRDSVTNPGQ---------YVLTG-MHAGQPK
HLLLVD--------PEGV----VRTKDVLFESISHLI------------DYHLQNGQPIVAAESE----LHLRGVVKREP
--------------
>Xenopus_tropicalis_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MLAESRYDRFRNDSITSAEEQLALSAEAMSGQVAPSSPTGASALEPQYPEEQDV
ATTFCMMIPRMGQWKFSSPTAFLSRSPSGAN-------------------KELTVDKSGTGGGLGSVFGACDPVCSTPCT
L-----------------QVINRLRGGGSGGARKSARTEAY----------KVQGEEWNRKGTFINKPAQGWLHPDDRLQ
G-----PGVSYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLYETV---PGVRG--TWKKKAPNKS
LASILG-RSNLRFAGISIAVNISTEGLNLSIPTSRQQVIAN----HHMQAISFASGGD-----ADTTDYVAYVAK--DPI
NQRACHILECCEGLAQSVIST-------VGQAFELRFKQF-------------LHSPP----------------------
------------------KVAAPPDRL---------LVGTEEPAWGGEEEQ-----------EHNYYNSIPGKEPPLGGL
QDSRIREAGATGQLSTQININGQ-------WSQVGSPARKPAV-----------------SHSCSQWDLED---------
----QAQASEGFPLTNGRAFG-----VRDYEEHMYVNTQNLDGLVA---DKE---------PYMIPEDSPKKDLFDMR--
----------------PFEDALKLHESSLSAS------------QSLEDQWPSPPTRRAPVAPTEEQLRGEPWYQGKMSR
REAEKLLQRDGD----------------------------------FLVRDSITNPGQ---------YVLTG-MHKGQPK
HLLLVD--------PEGV----VRTKDVLFESISHLI------------SYHLHNQQPILAAESE----LHLRQVVPRKV
--------------
>Danio_rerio_SHC2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------MNRRTRVEG-------------------------------------------------
---------------------------------------------------IWLGDNFTQKGSFINKPSQGWLHPDKKIS
S-----TGASYIVRYMG-------CIEVLKSMRSLD--FSTRTQ---VTREAINRLCESV---PGGKT--AWKKKTTNKT
LQSIMG-KSNLRFAGMSIGVNISIDGLSLLVPTTR-QVIAH----HPMQSISFASGGD-----SDTPDYVAYVAK--DPV
NQRACHILECCDGLAQNVIST-------IGQAFELQFKQY-------------LHSPP----------------------
------------------KAIPAMDSHAEYPNILSRNIRTEESAWGEDEES----------SEHDYYNSIPGKEPPVGGV
VDSRLRPP------AGLLGHVHTHPQ--SKTSQMGSPAKRDAN-----------SLPATHLCYEVHWDTENNRS------
----SSLTSDGYLRADGHPPG-----SRDYEEHLYVNTQNLDNLE-------AS-------VVGRRPESPKKDIFDMR--
----------------PFEDALRLHEASG--------------VCVLEDKWPSPPRRRAPVAPTEDQLRREMWYHGRMSR
RDAENLLGRDGD----------------------------------FLVRDSATNPGQ---------YVLTG-MQCGLPK
HLLLVD--------PEGV----VRTKDMLFESISHLI------------NYHLTNKLPIVAAESE----LHLQQVVCRKI
--------------
>Takifugu_rubripes_SHC2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------MLLKPKYDRFRNESVTSSDDLMQSLAMSSKVVATPVVPSSAPSLPLPPLPPLD
PGARSSLIPKMPQWKFSN--SLLSRSPSNTGSGSNSS----KDSGK------------------AAAAPSHAPVPPSSS-
---------------------SPQ----------------------RSSTMSSAGG---PKGSFIHKPSQGWLHPDKKIA
G-----PGASYIVRYMG-------CIEVLRSMRSLD--FNTRTQ---VTREAINRLCEVV---PGGRG--AWRKKSTNKA
LQTVMG-KSNLRFAGMSIAVNISIDGLSLLIPTTR-QVIAH----HPMQSISFASGGD-----TDTPDYVAYVAK--DPV
NQRACHILECSDGLAQGVIST-------IGQAFELQFKQY-------------LHSPP----------------------
------------------KTLASVE----------RSVRTEEPIWGEEESF----------SDHNYYNSIPGKEPPIGGV
VDSRLRGVP----QNCIMRGQDTSEF--LRRNQASYPSGQ--------------------LCYELHWDTETTSS------
----SGLTSDGYLCADGQSAG-----GKDYEEHQYVNTQNLDNLT--SQGAEGP-------RAGRAPDSPLKDIFDMR--
----------------PFEDALKLHEACAGAAGP--TAAAAGGTQVLEDQWPSPPRRRAPVAPNEEQLRREPWYHSRMSR
RDAERLLIRDGD----------------------------------FLVRESTTNPGQ---------YVLTG-MHCGLPK
HLLLVD--------PEGV----VRTKDMLFDSINHLI------------AYHLKNELPIVAAESE----LHLKQAVRRKP
--------------
>Tetraodon_nigroviridis_SHC2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------LRAAPPGMLLKPKYDRFRNESVTSSDDLMQSLAMSSKVVATPVVPSSAPSLPLPPLDDAT
T-TFCMLIPKMPQWKFSN--SLLSRSPSNSSSGSSSS----KDSGK------------------AAAAPSQAPVAPTSSP
Q-----------------RNSTMSSAGGP---------------VTRVEGMWLAGEDFTQKGSFIHKPSQGWLHPDKKIA
G-----PGASYIVRYMG-------CIEVLKSMRSLD--FNTRTQ---VTREAINRLCEAV---PGGRG--AWRKKSMNKA
LQTVMG-KSNLRFAGMSIAVNISIDGLSLLIPTTRQQVIAH----HPMQSISFASGGD-----TDTPDYVAYVAK--DPV
NQRACHILECSDGLAQSVIST-------IGQAFELQFKQY-------------LHSPP----------------------
------------------KSMASVE----------RSARAEEPIWGEDEGF----------SDHDYYNSIPGKEPPIGGV
VDSRLRGS------GAPLGHV--------HSQPLGCTAAQ--------------------VTLQTD-DVNGMGS------
----PARRDQASYPPDGQSAG-----SKDYEEHQYVNTQNLENLT--SLGAEGP-------RGGRAPDSPKRDIFDMR--
----------------PFEDALKLH----------------------------PPRRRAPVAPNEEQLRRETWYHSRMSR
RDAERLLIRDGD----------------------------------FLVRESTTNLGQ---------YVLTG-MHCGLPK
HLLLVD--------PEGV----VRTKDMLFDSISHLI------------AYHLKNELPIVAAESE----LHLKQAVRRKQ
--------------
>Gasterosteus_aculeatus_SHC2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MPQWKFSN--SLLSRSPSNSSSSSGSS----KDSGKAAAPQTSSSHSSSSHRHLAAVLTSCDPGCVTPC-
---------------------SLQAMRGQRVVAASSGSRSGMNRRTRVEGMWLGGEDFTQKGGFIHKPSQGWLHPDKKIA
G-----PGASYVVRYMG-------CIEVLKSMRSLD--FNTRTQ---VTREAINRLCDIV---PGGKG--AWRKKAQNKA
LQSVMG-KSNLRFAGMSIAVNISIDGLSLLIPTTR-QVIAH----HPMQSISFASGGD-----TDTPDYVAYVAK--DPV
NQRACHILECSDGLAQGVIST-------IGQAFELQFKQY-------------LHSPP----------------------
------------------KTMASAE----------RCARTEEAMWAEDEDF----------SQHDYYNSIPGKEPPVGGL
VDSRLRPS------GALLGHI--------HTQPQSKTAAQQTGSPGRREQA---SYPPGQLCYELHWDTETTGS------
----SGLTSDGYLCADGQPPG-----SRDYEEHQYVNTQSLENLDVLAQGPNGH-------RGSRAPESPKKDLFDMR--
----------------PFEDALKLHEACGGPA----AGAG---VRVLEDQWPSPPRRRAPVAPNEDQLRRETWYHSRMSR
RDAEKLLVRDGD----------------------------------FLVRESTTNPGQ---------YVLTG-MHCGLPK
HLLLVD--------PEGV----VRTKDMLFESISHLI------------AYHLKNELPIVAAESE----LHLKQVVRRKQ
--------------
>Oryzias_latipes_SHC2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MPQWKFSN--SLLSRSPSNSSSSSNSS----KDSGKAAG---APSQASS---TLAAVLNSCDPVCVTPC-
---------------------SLQAIRGQRAVAAAN-SAAG------------AAEDFSHKGNFINKPSQGWLHPDKKIA
G-----QGASYIVRYMG-------CIEVLKSMRSLD--FNTRTQ---VTREAINRLCEAV---PGGRG--VWRKKAFNKA
LQTVMG-KSNLRFAGMSIAVNISVDGLGLLIPTTR-QVIAH----HPMQSISFASGGD-----SDTPDYVAYVAK--DPV
NKRACHILECSDGLAPSVIST-------IGQAFELQFKQY-------------LHSPP----------------------
------------------KSMGSLE----------RSVRPEEPVWGDDEDP----------SEHDYYNSIPGKEPPIGGV
VDSRLRPA------GALLGHV--------HTQPPSKQAPQ------------------------LHWDTDMTCS------
----SGETPDGYLCADGQPTG-----IKDYEEHQYVNTQSLEHLD--AQGADGQ-------RGP--NDSPKKDLFDMR--
----------------PFEDALKLHKACGGAG----SQAGGGVVPILEDQWPSPPRRRAPVAPNEEQLRREPWYHSRMSR
RDAEKLLVRDGD----------------------------------FLVRESTTNPGQ---------YVLTG-MHCGLPK
HLLLVD--------PEGV----VRTKDMLFESISHLI------------SYHLKNGLPIVAAESE----LHLKQVVRRKQ
--------------
>Caenorhabditis_elegans_SHC2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------MLNVEPSFAEELR
S-----SGVSLSATYLG-------SVPVVESINVMVS--EMRVQ---VVSECIQHVAATVG---------VTAAREINPV
VSRVIG---EVKKENFPVDINISSKMIKIIK-QSR--LIQR----HPFSFFSFGAQGQKG---TDTELMFGYIAKNKDGT
DRRCHVVFIEDVHKLIDVLTTAI-----NVNTFDAQANAS----------------------------------------
----------------------------------------------------------------TSNDGFTVPAPPMRHR
--------------------------------------------------------------------------------
-------------------------------------------------------------------SSLHRQSFVSN--
----------------------------------------------------------CRAPTVTEDVVGKVWYHGNLSR
EDAQALLKTEGD----------------------------------FLVRQSDHTPGK---------YVLSGRTAENEHK
HLILLD--------NHNR----VRTRDRTFSNISELI------------DYHVNNGMAVRSEGRDRETSLNLIRPVPCPG
SDDIE---------
>Homo_sapiens_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGG------------KVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGSAP-
-------------------SAPRAP-AMSAARKGRP------------------------GDEPLPRPPRGAPHASDQVL
G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPT----------------------
------------------KIPALHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKMPPPGGF
LDTRLKPR------PHAPDTAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQQTPLRQG-------
-------SSDIYSTPEGKLHV-----APTGEAPTYVNTQQIPPQAWPAAVSSAE-------------SSPRKDLFDMK--
----------------PFEDALKNQP------------LGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSR
KEAEGLLEKDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK
HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLESSLPIVSAGSE----LCLQQPVERKQ
--------------
>Gorilla_gorilla_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGG------------KVSAARATPAAAPYLVSGKALRKAPDDG
PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGSAP-
-------------------SAPRAP-AMSAARKGRP------------------------GDEPLPRPPRGAPHASDQVL
G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPT----------------------
------------------KIPALHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKMPPPGGF
LDTRLKPR------PHAPDTAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQQTPLRQG-------
-------SSDIYSTPEGKLHV-----APTGEAPTYVNTQQIPPQAWPAAVSSAE-------------SSPRKDLFDMK--
----------------PFEDALKNQP------------LGPMLSKAASVECISPVSPTAPDAKMLEELQAKTWYQGEMSR
KEAEGLLEKDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK
HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLESSLPIVSAGSE----LCLQQPVERKQ
--------------
>Macaca_mulatta_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGG------------KVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGSAP-
-------------------PAPRAP-AMSTARKGRP------------------------GDEPLPRPPRGAPHASDQVL
G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPT----------------------
------------------KIPALHDRM----------QSLDEP-WTEEEGEG---------SDHPYYNSIPSKMPPPGGF
LDARLKPR------PHAPDTAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQQAPFRQNE------
----RQGSLDIYSMPEGKLHV-----APTGEAPTYVNTQQIPPQAWPTVVSSAE-------------SSPRKDLFDMK--
----------------PFEDALKNQP------------LGPVLSKAASVECISPVSPRAPDAKMLEDLQAETWYQGEMSR
KEAEGLLEKDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK
HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLESSLPIVSAGSE----LCLQQPVERKQ
--------------
>Mus_musculus_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------MSATRKSRA------------------------GDEPLPRPPRGAPHTSDQVL
G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---VTREAISRVCEAV---PGAKG-ALKKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPS----------------------
------------------KVPALQDRM----------QSLDEP-WTEEEGDG---------PDHPYYNSVPTKMPPPGGF
LDARLKGR------PHAPEAAQFA-----GKEQTYYQGRHLGDT----------------FGEDWQRAPTRQG-------
-------SLDIYSTAEGKTHM-----VPVGETPTYVNTQPVPPQVWPAATSSTE-------------SSPRKDLFDMK--
----------------PFEDALRNQP------------LGPMLSKAASVECISPVTPRAPDARMLEELNAEPWYQGEMSR
KEAEALLREDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK
HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NYHLESSLPIVSAGSE----LCLQQPVERKP
--------------
>Rattus_norvegicus_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGG------------KVS---AEPAASPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSS-G----LRGLSSAARERAGARL---------------------SGSCSAPSLAAPDGGSAT
-----------------PGSRAPAA-SMSATRKSRA------------------------SDEPLPRPPRGAPHASDQVL
G-----SGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---VTREAISRVCEAV---PGAKG-AFKKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMRSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPS----------------------
------------------KIPALQDRM----------QSLDEP-WTEEEGDG---------PDHPYYNSVPNKMPPPGGF
LDARLKAR------PHAPDAAQFS-----GKEQTYYQGRHLGDA----------------FGEDWQRAPTRQG-------
-------SLDIYSTPEGKAHM-----VPVGETPTYVNTQPVPPQVWPAATSSTE-------------SSPRKDLFDMK--
----------------PFEDALRNQP------------LGPVLSKAASVECISPVTPRAPDAKMLEELNAEPWYQGEMSR
KEAEALLQEDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHNGQAK
HLLLVD--------PEGT----VRTKDRVFDSISHLI------------TYHLESSLPIVSAGSE----LCLRQPVERKP
--------------
>Canis_familiaris_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------MRSLD--FSTRTQ---ITREAISRVCEAV---PGTKG-AFRKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVIGS-------IGQAFELRFKQY-------------LQCPS----------------------
------------------KVPAFHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKTPPPGGF
VDVRLHAR------PHAPDTAQFA-----GKEQTYYQGRHLGDP----------------FGEDWQQTPVRQG-------
-------SLDIYSTPEARVPA-----AP-GEAPTYVNAQHIPVQATPASGSSTE-------------SSPLKDLFDMK--
----------------PFEDALRNQS------------LGPVLSKAASVECISPVTPRAPDAKMLEELEGEPWYQGEMSR
KEAEGLLKNDGD----------------------------------FLVRKSATNPGS---------FVLTG-MHNGQAK
HLLLVD--------PEGT----IRTKDRVFDSISHLI------------NHHLENSLPIVSAGSE----LCLQQPVEKTL
--------------
>Myotis_lucifugus_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLPRTKYNHFKKDSVTSVDDLLHLS-VSGGSK------------VSAARAAPAAAAPYLVSGDALRRAPDDG
SGSRGHLLHKVSHLKLASS-G----LRGLS-AARERAGARL---------------------SGSCSAPSLAAPDGSAP-
-------------------PGPRAP-AMRAARKGRP------------------------GEE----PPPSAPPASDQVL
G-----AGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFRKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTSDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVIGA-------IGQAFELRFKQY-------------LRCPS----------------------
------------------KVPALHDRM----------QSLDEP-WTEEEGAG---------SDHPYYNSIPNKAPPAGG-
VDARLKAR------PHGPDSAPFS-----GKEQTYYQGRHVGEP----------------FGEDWQQTPARQG-------
-------SLDTSSMPGGTAPA-----APTGEAPTYMNTPHFPPQAGPAAGSSAE-------------SSPRKDLFDMK--
----------------PFEDALKNQP------------VGPVLSKAASVECISPVSPRAPDAKMLEELKAELWYQGQMSR
KEAEGLLKRDGD----------------------------------FLVRKSTTNPGS---------FVLTG-MHDGQAK
HLLLVD--------PEGT----IRTRDRIFDSISHLI------------NHHLANRLPIVSAGSE----LCLQQPVERNP
--------------
>Pteropus_vampyrus_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------RKADDG
PGSLGQLLHKVSH-KLSSS-G----LRGLS-AARERAGARL---------------------SGSCSAPSLAAPDGSAP-
-------------------PGPRAP-AMRASRKGRP------------------------GDE----PPPRASPASDQVL
G-----AGVTYVVKYLG-------CIEVLRSMRSLD--FSTRTQ---ITREAISRVCEAV---PGAKG-AFRKRKPPSKM
LSSILG-KSNLQFAGMSISLTISTASLNLRTPDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCDGLAQDVISS-------IGQAFELRFKQY-------------LQCPS----------------------
------------------KISAFHDRM----------QSLDEP-WTEEEGDG---------SDHPYYNSIPSKTPPPGGF
VDARLKVR------SHVPDTAQFA-----GKEQTYYQGRHLGEL----------------FGEDWQQTPIRQG-------
-------SVDIYSMPEGKAHV-----APTGEAPTYVNTQHFPLQAGPSASSSAE-------------SSPRKDLFDMK--
----------------PFEDALKNQS------------IGPVLSKAASVECISPISPRAPDAKMLEELKAEPWYQGEMSR
KEAEGLLKRDGD----------------------------------FLVRKSTTNLGS---------FVLTG-MHDGQAK
HLLLVD--------PEGT----IRTKDRIFDSISHLI------------NHHLENSLPIVSAGSE----LCLQQPVERNL
--------------
>Gallus_gallus_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLQRTKYNRFRNDSVTSVNDLIHNLSMNSKVS---------------AAATASAASSYLVTPEVLRKDQEDG
PTTLCTLIHKVSHLKFSNA-GSLLGIKNLSSAVKELAVSKL---------------------QGSSSASSSAAEASDNAC
NLVSATSCSQQDISKMSVGKKARSEEMHPGDEDWNQ------------------------RSSIVDKPSQGWLHLSEKIL
G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FNTRTQ---ITREAISRVCEAV---PGAKG-AFKKRKPPSKV
LSSILG-KSNLQFAGISIMLNISTTSLNLMTPDMK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECCNGLAQDVIST-------IGQAFELRFKQY-------------LQCPS----------------------
------------------KMPTFHDRM----------QSFDEP-LMEEESAA---------AEHPYYNNIPNKMPPPGGF
INARLKAKI-----PTAADTAQFAA--GVRREKIYYQNRHLGDK----------------FNEDWHEETVKQG-------
-------PLDIYSMPEGKSEA-----TARAEMPMYVNAQHINMETLLALQADAESD-ISGNTDSTKESSPEKDLFDMKLE
----------------PFEDALKNQT------------SEPVLSKLTSVECTSPLLCRAADWTRTEDLSIEPWYQGEMSR
KEAEQLLKKCGD----------------------------------FLVRKSTTNPGS---------YVLTG-MQNGQAK
HLLLVD--------PEGT----VRTKDRVFDSISHLI------------NHHLENNLPIVSSGSK----LCLQQPAERKH
--------------
>Xenopus_tropicalis_SHC3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLQRTKYNRFKNESVTPVDDLLHNLSMNSKVT---------------TVAGNPASPPCSAPPDVLQKDQENG
PTTLCTFIHKVSNLKLSSS-GSLLGIKNLSSAVKELTGSKL---------------------QGSSPALSIAAGATENTC
NLVS-TPCSQQDLNKMSTG-KKTPEEMHQGGEDWNQ------------------------SSSFVNKPSRGWLHSNEKIL
G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FNTRTQ---ITREAFNRVCEAV---PGTKG-VFKKRKPANKN
LSSILG-KSNLQFAGMSITLNISTTSLNMMTPDTK-QIIAN----HHMQSISFASGGD-----PDATDYVAYVAK--DPV
NRRACHILECCDGLAQDVIST-------IGQAFELRFKQY-------------LQCPS----------------------
------------------KIPVFPDRM----------QSLDDPLWQEEDGMT---------TEHQYYNSIPNKMPPPGGI
IDERLKTHI-----SNQGDNTQS-----VPLEQSYYQGRHLVEK----------------SCENFQQTVKRQA-------
-------SLDIYSLPEGKSSI-----NQTSNAPTYVNTQHINKKTLGAIQKSADSI-LCKSVDSSRDISPRKDIFDMK--
----------------PFEDALKNQ---------------PVLSKDASVDCSSPLLSRAAILTINEELRSEPWYVGEMCR
REAEKLLKRDGD----------------------------------FLVRKSINNPGS---------YVLTG-MHNGLAK
HLLLVD--------PEGT----VRTKDRVFDSIGHLI------------NHHLENNLPIVSSGSE----LCLKQPMEGKP
--------------
>Danio_rerio_SHC3_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLHRAKYNRFRNESVTSVDELLHGLSMNAKVSAVP-------PSPPVGDPPYAPPADPDPAEESG-------
--TLCTLINKVSNLKFTNS-SGLLGIKGLPSAVKDLAVSKLQGGAA----------------AGASSSPASSTLAAASPL
E------------------PGSTSSGKKGRMEESQPSGEGWSL---------GGTGAAGCGG-LVNKPSHGWLHSSEKIS
G-----PGVTYVVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITRGLFNILLQMT---TGSDGEVINGDETPSKL
LSSILG-KSNLQFAGMSINLNISTSSLNLMTPDSK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECSDGLAQDVIST-------IGQAFDLRFQLY-------------LQCPSS---------------------
------------------KPSSIHDRV----------MSTDEPPWTEEGDET---------ADHHYYNSIPGKMPPPGGF
IDARLTNQ-------SQDSSQGAG------VDQTYYQGRPMFIQ----------------QEKTFNCMFNNK--------
------RSCDIYSLPEVKAQP-----PKAGEVPTYVNTQHIDTQVLAALQAETETN-ADSSTTGAPKDSPRKDLFDMKP-
-----------------FEDAIMTQ-------T----PAASELHKAASVDNSSPLLMRAAALRAHEELEDQRWYHGEMSR
RQAEKLLLHDGD----------------------------------FLVRKSTTNPGS---------YVLTG-MHNGLAK
HLLLVD--------PEGT----VRTKDHIFESISHLI------------GHHRDNNLPIVSAGSE----LCLKQPVDRKQ
--------------
>Takifugu_rubripes_SHC3_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLHRTKYNRFRNESVTSVDELLHGLPMNPKVSASP----ETSYTPPTEVQSFSTATASSTPACLGSDHLEDG
GTTLCTLINKVSGLKFSNS-GSLLGIKGLPSAVKDLAVSKL---------------------QAASSSGGSACGSHSVP-
--------------------CSQLEPAVGMSKKSRLDELQLG------------------------KPSRGWVHSSDKIS
G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITREAISLVCEAV---PGTKG-ALRKRKPPSKT
LSSILG-KSNLQFAGMSINLNISTSSLNLMTPDGK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECSDGLAQDVIGT-------IGQAFDLRFQQY-------------LQCPSS---------------------
------------------KISSPHDRV----------LNMEELTWTEEEEES---------TEHPYYNNIPGKMPPPGGI
VDTRLTNQN-----AAQDGCQMGPG----SIDQTYYQGRHCGEN----------------WGDDRKPIFIQQ--------
------GSFDIISLPESKGQA-----QR-AEMPAYVNTQQIDAQVLAALQAEGENV-TKGLASAPAKESPQKDLFDMKP-
-----------------FEDAIQSE----GPEH----SQAAGLHKAASVDNASPLLVRSLAFRAQEELEGQTWYHGIMSR
REAEKLLQDDGD----------------------------------FLVRKSTTNPGS---------YVLTG-MHNGLAK
HLLLVD--------PEGT----VRTKDHVFDSILHLI------------GHHRDNNLPILSAGSE----LFLLQPVGRKQ
--------------
>Tetraodon_nigroviridis_SHC3_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLHRTKYNRFRNESVTSVDELLHGLPMNPKVSASP----ETSYTPTAEVQSSSTTTASSTPASLGSNHLEDG
GTTLCTLINKVSGLKFSNS-GSLLGIKGLPSAVKDLAVSKLQVGGGS---------------GSCGSGSPSPCGRLRVRP
P------------------RSPLLTAGAGRRHEQESVS----------------------------KPSRGWLHSSDKIS
G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITREAISLVCEAL---PGTKG-ALRKRKPPSKT
LSSILG-KSNLQFAGMSINLNISTNSLNLMTPDGK-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NRRACHILECSDGLAQDVIST-------IGQAFDLRFQQY-------------LQCPSG---------------------
------------------KISSPHDRV----------LNMEELTWTEEEEES---------AEHPYYNNIPGKMPPPGGI
IDTRLTSQN-----TAQDGCQMGPG----SIDQTYYQGRHCAEN----------------WGDDRKPVFIQQ--------
------GSFDVISLPESKVQA-----QK-VEMPAYVNTQQIDAQVLAALQAE-------------AKESPQKDLFDMTEP
-----------------FEDAIHSQ----GPEP----SQAAALSKAASVDNASPLLVRSLAFRAQEELEGQEWYHGIMSR
REAEKLLRDDGD----------------------------------FLVRKSTTNPGS---------YVLTG-LHNGLAK
HLLLVD--------PEGT----VRTKDHVFDSILHLI------------GHHRDNNLPILSAGSE----LFLLQPVGRKQ
--------------
>Gasterosteus_aculeatus_SHC3_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLHRTKYNRFRNESVTSVDELLHGLSMNPKVSATPQSAAETSYTPPTEVQPSAAAACS-ISTGHGSDHLEDG
GTTLCTLINKVSGLKFSNS-GSLLGIKGLPSAVKDLAASKLQGGGGLGS-------------GGGGGGGGGVPAAATS--
----------------------------------------------------GDWNPGGGGGGLVIKPSRGWLHSSEKIS
G-----PGVTYVVKYLG-------CIEVLCSMRSLD--FTTRSQ---ITREAISLVCEAV---PGTKG-ALRKRKPPSKA
LSSILG-KSNLQFAGMSINLNISTSSLNLMTPDCK-QIIAN----HHMQSISFASGGD-----PDTTDFVAYVAK--DPV
NRRACHILECSDGLAQDVIRT-------IGQAFDLRFQQY-------------LQCPSG---------------------
------------------KLSSTHDRV----------LNMEELPWTEEEEES---------AEHPYYNNIPGKMPPPGGF
IDTRLTTQN-----AAADG---CG---VQLLDQTYYQGRHCGEN----------------WGDERKVIFIQQ--------
------GSFDISGLPESKGQA-----PKTGEMPAYVNTQQIDAQVLAALQAEAE-------------HCPQKDLFDMKP-
-----------------FEDAIQSQ--SHPPSQ----PQVAAIHKTASVDNCSPLLARSVAFRAQEELQGQMWYHGQMSR
RDAEKLLKEDGD----------------------------------FLVRTSTTNPGS---------DVLTG-MHNGLAK
HLLLVD--------PEGT----VRARRA----------------------------------------------------
--------------
>Oryzias_latipes_SHC3_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------MLHRTKYNRFRNESVTSVDELLHGLSMNPKVSATPHSAAETPYTPPTEVQSSSGTPLSNAPTSHGSDHLEDG
GTTLCTLINKVSNLKFSNS-GSLLGIKGLPSAVKDLAVSKLQGGGGSGS-------------SSGSSPSAATAAAASVP-
--------------------CSQQEPALSMSKKSRLDELLPSG---------EDWNPGGGGG-LVSKPSRGWLHSNEKIS
G-----PGVTYIVKYLG-------CIEVLRSMRSLD--FTTRSQ---ITREAISLVCEAV---PGTKG-ALRKKKPPSKA
LSNILG-KSNLQFAGMSINLNISTSSLNLMTPDCK-QIIAN----HHMQSISFASGGD-----PDTTDFVAYVAK--DPV
NRRACHILECADGLAQDVIST-------IGQAFDLRFQQY-------------LQCPSN---------------------
------------------KPSSTHDRI----------LNMEELPWTEEEEES---------TDHPYYNNIPGKMPPPGGF
IDTRLTNQN-----AASEGSQVCGKMATGSVDQMYYQGRHC-EG----------------WAEERRPIIIQQGL------
------GSFDIVGFPESKSQA-----AKTGEMPTYVNTQQIDAQVLAALQAEAENV-MKGMA-ATTKDSPQMDLFDMKP-
-----------------FEDAIQSHPPSQGQTQ----TPVSNLHKAASVDNSSPLLVRSLAFRAQEELEDQTWYHGKTSR
RDAEKLLKQDGD----------------------------------FLVRKSTTNPGS---------YVLTG-MHSGLAK
HLLLVD--------PEGT----VRTKDHIFDSISHLI------------GHHRDNNLPIVSAGSE----LCLLQPVARKQ
--------------
>Homo_sapiens_SHC4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MRERGQDSLAGLVLY
VGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVG----------------NKGSPQPPHPALAPHLPTEDATLPSQES
PTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGP------------SSPETSLSRSGTAPPPQ
-------------------QDLVGHRATALTPDSCP----------------------LPGPGEPTLRSRQDRHFLQHLL
G-----MGMNYCVRYMG-------CVEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-AIKKRKPPVKF
LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NQRACHILECHNGMAQDVIST-------IGQAFELRFKQY-------------LKNPS----------------------
------------------LNTSCESEE----------VHIDSHA----EERE----------DHEYYNEIPGKQPPVGGV
SDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNVHPRGVQSQ------
--------RDTSLLKHTCRVD-------LFDDPCYINTQALQSTPGSA-----------------GNQRSAQPLGSPW--
----------------HCGKAPET----------------------VQPGATAQPASSHSLPHIKQQLWSEECYHGKLSR
KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK
HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN
NPALLHSNK-----
>Gorilla_gorilla_SHC4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MRERGQDSLAGLVLY
VGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVG----------------NKGSPQPPHPALAPHLPTEDATLPSQES
PTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGP------------SSPETSLSRSGTAPPPQ
-------------------QDFVGHRATALTPDSCA----------------------LPGPGEPTLRSRQDRHFLQHLL
G-----MGMNYCVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-AIKKRKPPVKF
LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NQRACHILECHNGMAQDVIST-------IGQAFELRFKQY-------------LKNPS----------------------
------------------LNTSCESEE----------VHIDSHA----EERE----------DHEYYNEIPGKQPPVGGV
SDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNVHPRGVQSQ------
--------RDTSLLKHTCRVD-------LFDDPCYINTQALQSTPGSA-----------------GNQSSVQPLGSPW--
----------------HCGKAPET----------------------VQPGATAQPASSHSLPHIKQQLWSEECYHGKLSR
KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK
HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN
NPALLHSNK-----
>Macaca_mulatta_SHC4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MRERSQDSLAGLVLY
VGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVG----------------NKGSPQPPHPALAPHLPAEDAALPSQES
PTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSSP------------SSPETSLSRSGTAPPPQ
-------------------PDLVSHRATALTPDSCP----------------------LPGPGEPPLRSRQDRHFLQHLL
G-----MGMNYCVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-AIKKRKPPVKF
LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NQRACHILECHNGMAQDVINT-------IGQAFELRFKQY-------------LKNPS----------------------
------------------LDTSCESEE----------VRIDSHA----EESE----------DHEYYNEIPGKQPPAGGV
SDMRIKVQATEQMAYCPIRCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNVHPRGVQSQ------
--------RDTSLLKHTCRVD-------LFDDPCYINTQALQSTLGSA-----------------GNQSSAQPLGSPW--
----------------HCGKAPET----------------------VQPGATAQPASSHSLPHIKQQLWSEECYHGKLSR
KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK
HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN
NPALLHSNK-----
>Canis_familiaris_SHC4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MRRRGRDSLAGLVLC
VGLVGHPGMLHRAKYSRFRNESVTSLDESGPGGGAGG---------------DKGSPQPPYPALAPHLPPEDATLAAQES
PTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQESQDPAPSSP------------APPEAGLTRAGPAPLPQ
Q------------------PGPVGHRATVLTPEACP----------------------LPGAGQPTPGSRQDRHFLQHLL
G-----MGMNYYVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---SGANG-AVKKRKPPVKF
LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNIDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NQRACHILECRSGMAQDVIST-------IGQAFELRFKQY-------------LKNPS----------------------
------------------LNTSCESEG----------VPIDDHA----EERE----------DHEYYNEIPGKQPPAGGV
SDVRIKVQATEQMAYCPIRCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNAQERGVQSH------
--------RDASLMKHACRVD-------FFNDPCYINTQAFQSTLGSA-----------------PNQSSAHVLGSPW--
----------------HREKAPET----------------------VQPGATAQPASSHSLPHVKQQLRSEDCYHGKLSR
KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK
HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN
NPGLLHSNK-----
>Felis_catus_SHC4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MRKRGQDSLAGLVLY
VGLFGHPGMLHRAKYSRFRNESITSLDESSPGGSVG----------------SKGSAPPPYPTLAPHLPAEDATLASQES
PTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQESQDPAPSSP------------ASPETSPNRAGSAPLPQ
-------------------PDLLGHRAAALTPDACP----------------------LPGPGEPTPGSRQDRHFLQHLL
G-----MGMNYYVRYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---SGANG-AVKKRKPPVKF
LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNIDNQ-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NQRACHILECRSGMAQDVIST-------IGQAFELRFKQY-------------LKNPS----------------------
------------------LNTSCESEE----------VPLDGPA----VERE----------DHEYYNEIPGKQPPAGGV
SDVRIKDQATEQMAYCPIRCEKLCYLPGNSKCSSVYENCLEQSR-----------------AIGNAQERGGQCQ------
--------RDAALMKHTCRVD-------FLNDPCYINTQGLQSTLGSS-----------------PNQSSAHSLGSPW--
----------------HRQKAPET----------------------VQPGATAQPASSHSLPHIKQQLRNEDCYHGKLSR
KAAESLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQAK
HLLLVD--------PEGK----VRTKDHVFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRKDN
NPGLLHSNK-----
>Myotis_lucifugus_SHC4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MRERSPDGLAGLALH
VGLFGHPGMLHRAKYSRFRNESVTSLDEGSPGGSVG----------------NKGSPQPPYPALAPHLLAEDAPSPSQES
PTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQESQDPAPSSP------------ASPENSLNRSGSAPPQQ
-------------------RDVVGRRASALTPDACP----------------------LPGPGDPTPGSRQDRHFLQHLL
G-----MGMNYCVKYMG-------CIEVLQSMRSLD--FGMRTQ---VTREAISRLCEAV---PGANG-ATKKRKPPVKF
LSTVLG-KSNLQFSGMNIKLTISTCSLTLMNLDNH-QIIAN----HHMQSISFASGGD-----PDTTDYVAYVAK--DPV
NQRACHILECRNGMAQDVITT-------IGQAFELRFKQY-------------LKNPS----------------------
------------------LNTSCESEE----------VHIDGHA----DERD----------DHEYYNEIPGKQPPMGGV
SDVRVRVQATEQMAYCPIRCEKLCYLPGNSDCSSVYENCLEQSR-----------------AIGNAHERAVPSQ------
--------RDTALMKHTCRVD-------LFDDPCYINTQALHSALGST-----------------RNPGSAQLLGSLW--
----------------HREKAPET----------------------VQPGATAQPASSRSLPYIQQQLRSEDCYHGKLSR
KAAENLLVKDGD----------------------------------FLVRESATSPGQ---------YVLSG-LQGGQ-K
HLLLVD--------PEGK----VRTKDHIFDNVGHLI------------RYHMDNSLPIISSGSE----VSLKQPVRRDN
IPGLLHLNK-----
>Pteropus_vampyrus_SHC4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MRERSQDSLAGLVLY
VGLFGHPGMLHRAKYSRFRNESITSLD