>Homo_sapiens_CREB3
--------------------------------------------------------------------------------
--------------------------------MELELDAGDQ--------------------------------------
------------------------------------------------------------------DLLAFLLEESGDLG
TAPDE---------------------------AVRAPLDWALPLSEV----------P-----SDWEVDDLLCSLLSPPA
S-----------------------------------------------------------------------------LN
ILSSSNPCLVHHDHTYSLPRETVSMDLGESE-------------------------------------------------
--------------------------------------------------------------------------------
----------------------ISLGRTGFMGLAIHTFPFAESESCRKEGTQMTPQH-----------------------
-------------------MEE-LAEQE----------------------------------------------------
------------------------------------------------------IARLVLTDEEKSLLEKEGLILPETLP
LTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES-RVLKYTAQNMELQNKVQLLEEQ-NLS-LLDQLRKLQAMVIE
ISNK-----TSSSS-TCILVLL----------------------------VSFCLLLVPAMYSSDT--------------
----------RGSLPAEHGVLS---------------------------------------RQLRALPSEDPYQLELPAL
QSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYM-------------------PQAPSAEPPLEWPFPDLFSEPLCRGPIL
PLQANLTRKGGWLPTGSPS-VILQDRYSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pan_troglodytes_CREB3
--------------------------------------------------------------------------------
--------------------------------MELELDAGDQ--------------------------------------
------------------------------------------------------------------DLLAFLLEESGDLG
TAPDE---------------------------AVRAPLDWELPLSEV----------P-----SDWEVDDLLCS------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------SESCR-PLTQMTPQH-----------------------
-------------------MEE-LAEQE----------------------------------------------------
------------------------------------------------------IARLVLTDEEKSLLEKEGLILPETLP
LTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES-RVLKYTAQNMELQNKVQLLEEQ-NLS-LLDQLRKLQAMVIE
ISNK-----TSSSS-TCILVLL----------------------------VSFCLLLVPAMYSSDT--------------
----------RGSLPAEHGVLS---------------------------------------RQLRALPSEDPYQLELPAL
QSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYM-------------------PQAPSAEPPLEWPFPDLFSEPLCRGPIL
PLQANLTRKGGWLPTGSPC-VILQDRYSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Macaca_mulatta_CREB3
--------------------------------------------------------------------------------
--------------------------------MELELDAGDQ--------------------------------------
------------------------------------------------------------------DLLGFLLEESGDLR
TAPDE---------------------------SVRAPLDWELPLSEV----------P-----SDWEVDDLLSSLLSPPA
SS----------------------------------------------------------------------------LN
VLSNSNPCLVHHDHTYSLPREPVSMDLGESE-------------------------------------------------
--------------------------------------------------------------------------------
----------------------ISLGRTGFMGLAIHTFPFAESESCRKEGTQMTPQH-----------------------
-------------------MEE-LAEQD----------------------------------------------------
------------------------------------------------------IVRLVLTDEEKSLLEKEGLILPETLP
LTKMEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLES-RVLKYTAQNMELQNKVQLLEEQ-NLS-LLHQLRKLQAMVIE
ISNK-----TSSSS-TCILVLL----------------------------VSFCLLLVPAMYSSDT--------------
----------RGSLPAEHGVLS---------------------------------------RQLRALPSENPYQLELPAL
QSEVPKDCTHQWLDSSDHVLQAPGNSSCLLYYM-------------------PQAPSAEPPLEWPFPDLFSEPLCRGPIL
PLQANLTRKGGWLPTGSPS-VILQDRYSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Mus_musculus_CREB3
--------------------------------------------------------------------------------
--------------------------MDPGGQDLLALDPGDQ--------------------------------------
------------------------------------------------------------------DLLGFLLEESGDLW
AATEP---------------------------DVKAPLDLELSPSEN----------SVQE-LSDWEVEDLLSSLLSPSV
S-----------------------------------------------------------------------------RD
VLGSSSSS-ILHDHNYSLPQEHVSIDLGECEM------------------------------------------------
--------------------------------------------------------------------------------
----------------------ISCGRRELTGLAGSTFPFADTESFEKEGFHVTPLP-----------------------
-------------------GEERAAEQE----------------------------------------------------
------------------------------------------------------MSRLILTEEEKKLLEKEGLTLPSTLP
LTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLES-RVLKYTAQNRELQNKVQRLEEQ-NLS-LLDQLRKLQAMVIE
IANK-----TSSGS-TCVLVLV----------------------------FSFCLLLVPAMYSSDA--------------
----------RGSVPAEYVVLH---------------------------------------RKLRALPSEDDHQPKPSAL
SSELPMDSTHQSLDSSEHMFLVSSNFSCVLYHA-------------------PQA---EQPLHWPLWDLSSEMLFSDSNL
LLQANLSESEGWQPNHSPSLVIFQGRYSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Rattus_norvegicus_CREB3
--------------------------------------------------------------------------------
--------------------------MDPGGQDLLALDPGDQDLLALDPGDQ----------------------------
------------------------------------------------------------------DLLGFLLEESGDLW
AATEQ---------------------------DIETPLDLELSPSEN----------SVQE-LSDWEVEDLLSSLLSPSS
S-----------------------------------------------------------------------------PD
VLNSSSSS-ILHDHNYSLPQEHVSIDL-----------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------DPGSFEKEGFRMNPLR-----------------------
-------------------VEETAAEQE----------------------------------------------------
------------------------------------------------------LSTLILTEEEKRLLEKEGLTLPSTLP
LTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLES-RVLKYTAQNQELQNKVQHLEEQ-NLS-LLDQLRKLQAMVTE
IANK-----TSSGS-TCVLVLL----------------------------LSFCLLLVPAMYSSDV--------------
----------RGSVPAEYVVLH---------------------------------------RKLRALPSEDQHQPKLSAL
QPELPMGSTNQ-LESSEHTFLAPSNVSCLN-HM-------------------AQT---EQPPHWPLLDLSSEMPFSGSDL
LLQANLTESGGWLSTHSPSSIILQGRYSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Canis_familiaris_CREB3
--------------------------------------------------------------------------------
-----------------------------LSGMELALDLGDQ--------------------------------------
------------------------------------------------------------------DLLDFLLEESGDLG
AGP---------------------------------------PLSEA---------------LSEWEAEDFLSSMLSPPA
S-----------------------------------------------------------------------------LN
VLSSSDSCLVHHDHTYSLSQQHVSID------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------LDGGSYGKEEAQTTPLQ-----------------------
-------------------VEE-PAEQE----------------------------------------------------
------------------------------------------------------IARLILTDEEKRLLEKEGLTLHGTLP
LTKMEEQVLTRVRRKIRNKKSAQESRRKKKVYLGGLEN-RVLKYTAQNLELQNKVQLLEEQ-NLS-LLDQLRRLQAMLIQ
ISNK-----TSSSS-TCVLVLL----------------------------FSFCLLIVPAMYSSDT--------------
----------RGSLPAEHGVLS---------------------------------------RQLRALPSEDPHQLELPAL
QSEVPKD-------SSDQELQAPGNSCCPLYHL-------------------PQAPGAESPLKLPLPVPSSKSPCSCPLL
PLHANFTRDGGWLPTHSPTSVILQGRYSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Myotis_lucifugus_CREB3
--------------------------------------------------------------------------------
-----------------------------ISHMELALDPGEQ--------------------------------------
------------------------------------------------------------------DLLGFLLGESGDLG
AAPNE---------------------------VLEAPRDWELPLSEA---------------LSDWDVEDFLRSLPSPPA
S-----------------------------------------------------------------------------LN
IFSNSNPCLVHHDHTYSLSQEHVSID------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------LDSGSCGKEGVQMTPLH-----------------------
-------------------VED-PEEQE----------------------------------------------------
------------------------------------------------------VVGLILTDEEKRLLEQEGLTLPGTLP
LTKMEEQVLKRVRRKIRNKKSAQESRRKKKVYVGGLES-RVLKYTAQNLELQNKVQLLEEQ-NLS-LLDQLRRLQAMVIE
ISNK-----TSSSSSTCVLVLL----------------------------FSFCLALVPAMYSSGT--------------
----------RGSLPAERGVLS---------------------------------------RQLRALP----HQLELSVL
QSEEPKD-------SSDHELQAPGNSCCLPSHM-------------------PQAPGTEPPLKLPLPDPFSKFASLGPIV
PLHANLTREREWLPAHSPISVILQGRYSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pteropus_vampyrus_CREB3
--------------------------------------------------------------------------------
--------------------------------MELALDPDDQ--------------------------------------
------------------------------------------------------------------DLLGFLLEESGDLG
AVPKE---------------------------AMEAPMSWELPLSQA---------------LSDWDVEDFLSSLQSPPA
S-----------------------------------------------------------------------------LS
VLSNSNPCLVHHDHTYSLPQEHVSID------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------LDSESYGKEG-ALIPLH-----------------------
-------------------VEE-PSEQE----------------------------------------------------
------------------------------------------------------MVRLILTDEEKRLLEQEGITLPGTFP
LTKMEEQVLKRVRRKIRNKKSAQESRRKKKVYVGSLES-RVLKYTAQNLELQNKVQLLEEQ-NLS-LLDQLRRLQAMVVQ
IANK-----TSSSS-TCVLVLL----------------------------FSFCLLLVPAMYSSDT--------------
----------RGRLPSEHGVLS---------------------------------------RQLRGLSE-DLHQLELPAL
QPEVPKD-------SSDRELQAPGNS-CLFYLM-------------------PQALGTEPPMKLPLPDPFSKSPRPDPIL
SLHANLTREGEWVPAHSSICVILQGRHSG---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Danio_rerio_CREB3_b
--------------------------------------------------------------------------------
-----------------------------------MVNCMSQSPHG----------------------------------
--------------------------------------------------------------------SDSGISEDTTPP
HCQSP---------------------------HDGSETDTVPSPGQE----------PLLY--SECVTESYEAQVVQTDH
C----------------------------------------------------------------------------YTL
PQ----DTNTLLSVRSENPESDVFIDVDDL--------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------DASMEDDDFSPELPCSLT-----------------------
-------------------IEDSMQSSKLDS-------------------------------------------------
---------------------------------------------------QFQFKEIVLTDEEKRLLAKEGATIPSHMP
LTKAEERTLKRVRRKIRNKQSAQESRKKKKVYVDGLEN-RVAVCTAHNQELQKKVEMLHKQ-NMS-LIEQLRKLQAMVKM
STMK-----TTTTS-TCIMVFL----------------------------LSFCLIIFPSVNPFGS--------------
--------SDQKDLYASSTGMS---------------------------------------RALRSYPAIKKDNIISTSA
KEVVDQDVLLVATIENNQALLSAGQN-HTPDYG---WSSPTLSLESTATP----PPTSPLRHSQISKQTPLCP--NLTGT
LVHHRS-SMMARANPRRAGWSRNPPQS-----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Tetraodon_nigroviridis_CREB3_b
--------------------------------------------------------------------------------
-----------CPSRSPVGSDSGIS-----DDSSTG--AGPHNLRG----------------------------------
--------------------------------------------------------------------CLS--PQGSDTD
AVTSP---------------------------G-YSRGSPVPS--DP----------ALVP--EDMQTEKQEALSVQADH
S----------------------------------------------------------------------------YAL
LQVAAADMDALQSVRAEKPDTYVFIDLDNL--------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------VSEAVEDEL-NVLPCTLA-----------------------
-------------------IEDSLQERPLSP-------------------------------------------------
---------------------------------------------------QFQFKEIVLTEEEKRLLSKEGATIPTDMP
LTKAEERTLKRIRRKIRNKQSAQESRKKKKVYVDGLEN-RVAVCTAHNMELQKKVQLLQKQ-NIS-LIEQLRKLQAMVKM
STLK-----ASTTS-TCVMVFL----------------------------LSFCLIIFPAVNPFGKN-------------
--------TEQKELYTPSSVIS---------------------------------------RTLRSLPPESTDALP-YLA
AEEEDLLLVPHAELENVKSIFAGGQNNHTPDYG--------------WSS--PSPRPASTATPHPTSPL-----------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Homo_sapiens_CREB3L1
-------------------------------------------------------------MDAVLEPFPADRLFP---G
SSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFS-NDLFSSFFDDPVLD----------------------------EK
SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD
SAPQSP--------------------------LVPIKMEDT--TQDAEHG--------AWALGHKLCSIMVKQEQ--SPE
LP-VDPLAAPS---------------------------------------AMAAAAAMATTPLLGLSPLSRLP-IPHQA-
----PGEMTQLPVIKAEPLEVNQFLKVTP----------EDLVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSHGSDSDGSQSPRSL----------------------
---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP
LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN
K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSGSQ--------
---------TVKEDPLAADGV----------------------------------------YTASQMPSRSLLFYDDGAG
LWEDG-RSTLLPMEP-----PDGWEINPGGPAEQRPRDH--------------LQHDHLDSTHETTKYLSEAWPKD-GGN
GTSPDFSHSKEWFHDR--DLGPNTTIKLS---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pan_troglodytes_CREB3L1
-------------------------------------------------------------MDAVLEPFQADRLFP---G
SSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFS-NDLFSSFFDDPVLD----------------------------EK
SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD
SAPQSP--------------------------LVPIKMEDT--TQDAEHG--------AWALGHKLCSIMVKQEQ--SPE
LP-VDPLAAPS---------------------------------------AMAAAAAMATTPLLGLSPLSRLP-IPHQA-
----PGEMTQLPVIKAEPLEVNQFLKVTP----------EDLVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSHGSDSDGSQSPRSL----------------------
---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP
LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN
K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSGSQ--------
---------TVKEDPLAADSV----------------------------------------YAASQMPSRSLLFYDDGAG
SWEDG-RSTLLPMEP-----PDGWEINPGGPAEQRPQDH--------------LQHDHLDSTHETTKYLSEAWPKD-GGN
GTSPDFSHSKEWFHDR--DLGPNTTIKLS---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Macaca_mulatta_CREB3L1
--------------------------------------------------------------------------------
------------------HFPEHLDHFTENMEDFS-NDLFSSFFDDPVLD----------------------------EK
SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD
SAPQSP--------------------------LVPIKMEDT--TQDVEHG--------AWALGHKLCSIMVKQEQ--SPE
LP-VDPLAAPS---------------------------------------AMSAAAAMATTPLLGLSPLSRLP-IPHQA-
----PGEMTQLPVIKAEPPEVNQFLKVTP----------EDLVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSHGSDSDGSQSPRSL----------------------
---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP
LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN
K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSGSQ--------
---------TVKEDPMAADSI----------------------------------------YTASQMPSRSLLFYDDGAG
SWEDG-RSALLPMEP-----PDGWEINPGGPAEQRPQDH--------------LQHDHLDNSHETTKYLSEAWPKD-GGN
GTSPDFSHSKEWFHDR--DLGPNTTIKLS---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Mus_musculus_CREB3L1
-------------------------------------------------------------MDAVLEPFPADRLFP---G
SSFLDLGDLNESDFLNNAHFPEHLDHFVENMEDFS-NDLFSSFFDDPVLD----------------------------EK
SALL--DMELDSPAP----------------------------------------------------GIQAEHSYSLSGD
SAPQSP--------------------------LVPVKMEDT--TQDVEHG--------AWALGNKLCSIMVKQEQ--SPE
LP-VDPLAASS---------------------------------------AMAAAAAMATPPLLGLSPMPRLP-IPHQA-
----PGEMTQLPVIKAEPPEMSQFLKVTP----------EDLVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSHGSDSDGSQSPRSL----------------------
---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP
LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETYTSENNELWKKVETLET--ANRTLLQQLQKLQTLVTS
K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPAFSSGSM--------
---------TVKEDPIAADSV----------------------------------------YAASQMPSRSLLFYDDGAG
SWEDG-RGALLPVEP-----PEGWELKPGGPAEQRPQDH--------------LRHDRADSIHETTKYLRETWPEDTDDN
GTSPNFSHPKEWFHDR--DLGPNTTIKLS---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Canis_familiaris_CREB3L1
-------------------------------------------------------------MDAVLEPFPVDRLFP---G
SSFLD-GDLNESDILNNAHFPEHLDHFAENMEDFS-NDLFSSFFDDPVLD----------------------------EK
SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD
SAPQSP--------------------------LLPIKMEDT--TQDVEHG--------AWVLGHTLCSVMVKQEQ--SPE
LP-VDPLAASS---------------------------------------AMAAAAAMATTPLLGLNPLSRLP-VPHQA-
----PGEMTQLPVIKAEPQEVNQFLKVTP----------EDLVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPLTPPSSHGSDSDGSQSPRSL----------------------
---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP
LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN
K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSSSQ--------
---------TVKEDPMATDSV----------------------------------------YTASQMPSRSLLFYDEGAG
SWEDG-RGALLPVEP-----PDGWEINPGGPAEQRPQDH--------------LQHDHLDSTHETTKYLSEAWPKDIGGN
GTSPDFSHPKEWFRER--DLGPNTTIKLS---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Felis_catus_CREB3L1
-------------------------------------------------------------MDAVLEPFPADRLFP---G
SSFLDLGDLNESDFLNNAHFPEHLDHFAENMEDFS-NDLFSSFFDDPVLD----------------------------EK
SPLL--DMELDSPTP----------------------------------------------------GIQAEHSYSLSGD
SAPQSP--------------------------LVPIKMEDT--TQDVEQE--------AWVLGHKLCSVMVKQEQ--SPE
LP-VDPLAASS---------------------------------------AMAAAAAMATTPLLGLSPLSRLP-VPHQA-
----PGEMTQLPVIKAEPQEVNQFLKVTP----------EDLVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPLTPPSSHGSDSDGSQSPRSL----------------------
---------PPSSPVRPMARSSTAISTS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP
LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETFTSENNELWKKVETLEN--ANRTLLQQLQKLQTLVTN
K-ISRPYKMAATQTGTCLMVA----------------------------ALCFVLVLGSLVPCLPEFSSSSQ--------
---------TVKEDPVAADSV----------------------------------------YTASQMPSRSLLFYDEGAG
SWEDG-RSALLPVEP-----PDGWEIKPGGPAEQRPQDH--------------LQLDHLDSTHETTKYLSEAWPKDVGGN
GTSPDFSHPKEWFRER--DLGPNTTIKLS---------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Taeniopygia_guttata_CREB3L1
--------------------------------------------------------------------------------
------------------HFSENLDHFSDNMEDFS-NDLFSSFFDDPVLA----------------------------EK
NPLL--DMDLDPPTP----------------------------------------------------GIQAEHSYSLSGD
SAPQSP--------------------------LVPVKTEDN--ASELENG--------VWSLGPKLCSIMVKQEQNLPLD
LP-ESQLPASS-------------------------------------------------IPVLNLNPLQRLP-LPEEI-
----PIEITPAPVIKAEPKEVNQFLNVPT----------DDLVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSHGSDSDGSQSPRSL----------------------
---------PPSSPARPAARSSTAISSS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLLLTEEEKRTLIAEGYPIPTKLP
LTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVETYTTENNELWKKVETLEN--ANRTLLQQLQKLQALVAG
K-VSRPYKMASTQTGTCLMVL----------------------------ALCFVLILGSLMPCLPEFSSASQ--------
---------TVKATP--APDI----------------------------------------YTTSKIQSRSLLFYDEGAG
SLEES-YSSFLTMDH-----PEGWEAK-----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Danio_rerio_CREB3L1_a
-------------------------------------------------------------MDTILDNFASDK------L
FPNSNLLDLEDLNESD-FLSNVH---FSEQMEDFSNDLFN-SFFDDHLL------------------------------A
ERNPLLDMDL-DPPNP---------------------------------------------------DIQAEHSYSLSED
SAPQSP--------------------------SIPIKSDDDADSEAMWSF-------------SQDLTAILVKQEPSLMS
E--NCPETAPP-----------------------------------------LANSSTCSPPLTLAPPPQRNHSGEKGS-
---KGLSSNSVPAIKAEPREANQFLNVPSE----------EHLR------------------------------------
--------------------------------------------------------------------------------
------------------------------------LPPTPPSSHGSDSDGSQSPHSLPPLSPG----------------
HLQSPHS-LPPSSPARLQARTSTAISSS---PLLTAPHKLQG--------------------------------------
-----------------------------------------------------TSGPLMLTEEEKRTLIAEGYPVPNKLP
LTKTEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVENYTSENNELWKKVETLEN--ANRSLLQQLQRLQALVSG
K-VPRSCKIASTQTGTCLMVV----------------------------ALCFVLVLGSLAPC-LPELSLYSS-------
---------SLSSSSSHTVKS----------------------------------------APLPSGDLYTTSQVRSRSL
LFYDEGVPVEDGHR-----GLLSVERTEGVPRHVQDVKD--------------SSHKQDHSALVSRYLSEAQPESASYSN
TSAAPLRPPEPHYHSRKRDPEGGAEYF-----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Takifugu_rubripes_CREB3L1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------D----------DTVQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------LPPTPPTSNHGDSDGS-----LPPSSP-----------------
HLP-----LPQSSP---------AISSS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLMLTEEEKRTLVAEGYPIPNKLP
LTKSEEKALKRVRRKIKNKISAQESRRKKKEYVECLEK-KVESYTSENSDLWRKVENLET--ANRSLLQQLQKLQTLISG
KVVPHSCKIASTQTGTCLMMM----------------------------ALCFVLVLGSFSSC-LSPLSF----------
-----------PTDT-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Oryzias_latipes_CREB3L1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------KLQG--------------------------------------
------------------------------------------------------SGPLMLTEEEKRTLVAEGYPVPNKLP
LTKSEEKALKRVRRKIKNKISAQESRRKKKEYVDCLEK-KVESYTSENGDLWRKVENLET--ANRSLLQQLQKLQSLISG
KVIPRSCKIASTQTGTCLMMV----------------------------ALCFVLVLGSFSPC-LSPLSL----------
----------LSHSS-----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Branchiostoma_floridae_CREB3L1
MEQYHGQQYPGDQGQGPYGDQWGYDGGWDRPSCALQDRRVYPQHLPPPNQHPAFPCILPSMTSKIDNNNPQTPRVRVILS
LHQRPVRVLVVDRPVDGSTPVSAWVVRSRILSRLILTRKRRRRRFSAFPPNFGDYRHFCAGFRLKLHAMDSLAHDRKLSE
LGSNDFNDILDTDVFR---------------------------------------------------LPPNDQLDDLPSD
WLNGLL--------------------------DEPLIPDKPLNDVSLAPP---------PQIQAEHSYSMMSAADLAMEE
SLRIKTEENDF-----------------------------------------DMADWMTSGHMDHGMMHDDPMDYDMGNT
AYHMAEQMEPLDLIKIKTEPTDPDLYFHTG----------ADDLDVQ---------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSASSDSEGGSSPRAI----------------------
----PDSPTRP-TFSKQAGQSSGPMSPNPGQNLLTNFQKLPP--------------------------------------
------------------------------------------------------SGPLILTEEEKRTLISEGYPIPTKLP
LTKAEEKSLKKVRRKIKNKISAQESRRKKKEYVDQLEK-RVENFTHENNELRKKCNTLES--SNKTLLVQLQKLQALVN-
R-VPRPCRTNATQTGTCLMVGFKHSLSCSFSLTILLYMVRGSIPGLEVLVVFFAIFLGSWSPTLYLPSMTSYL-------
---------PTPFTHSVVQSN----------------SGPNHIGLAG-------------VPHSGGGDD--YTTPNRHSS
RALFAFTEEVTDDV---SHFEQGLDPVLEKLWQELPDDA--------------YAIVNNETDKPLVLSGGEEDAAFGPGT
VLHPDIAAEVS-SKLISLEHRANATA------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Caenorhabditis_elegans_CREB3L1
--------------------------------------------------------------------MDDDWATS----
----GVLEKDVFISSVHDEKDTLDILKLFDNDIDGFS--DDN------FR----IK-------------------MEPND
ETS----------------------------DYHGSSSG---------------------------SPSSSLSSPNEFKD
EPLGLDVHFG-----------------------NSLFNAPFSPSATSSHS-------PSSYGMMHGSHSMASHQLHQQQL
S-------------------------------------------------------------------------PLPSVA
HFSHSHHLQHHVVQHPSQASLQMNMNQIFSGPSH----------------------------------------------
--------------------------------------------------------------------------------
------------------------------------QYASSSVPHTFLFKDSTIYEG-----------------------
--------------MGGMGLAAAQQQLKARN-------------------------------------------------
-----------------------------------KMHEMAIRQHLITDQNITANGDLVLSAEERRTLVQEGYSIPQKYP
LTKSEEESLKIVRRKIKNKLSAQESRRKRKEYIDALEG-RLHCFSEENKSLKKQVHQLEA--SNRDLQQKLHQYESKEKM
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Homo_sapiens_CREB3L2
--------------------------------------------------------------MEVLESGEQG------VL
QWDRKLSELSEPGDGEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK
SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE
PRAQSP--------------------------FTHITTSDSFNDDEVESE--------KWYLSTDFPSTSIKTEPVTDEP
P---PGLVPSV-----------------------------------------TLTITAISTPLEKEEPPLEMN---TGV-
---DSSCQTIIPKIKLEPHEVDQFLNFSP------KEAPVDHLH------------------------------------
--------------------------------------------------------------------------------
------------------------------------LPPTPPSSHGSDSEGSLSPNPR----------------------
-LHPFSLPQTH-SPSRAAPRAPSALSSS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP
LSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRTLLQQLQKLQTLVMG
K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK--------
---------MALPSQHSLQEP----------------------------------------YTASVVRSRNLLIYEEHSP
PEESSSPGSAGELGG----WDRGS-SLLRVS-GLESRP-----------------DVDLPHFIISNETSLEKSVLLELQQ
HLVSAKLEGNETLKVVELDRRVNTTF------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pan_troglodytes_CREB3L2
--------------------------------------------------------------MEVLESGEQG------VL
QWDRKLSELSEPGDGEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK
SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE
PRAQSP--------------------------FTHITTSDSFNDEEVESE--------KWYLSTDFPSTTIKTEPITDEP
P---PGLVPSV-----------------------------------------TLTITAISTPLEKEEPPLEMN---TGV-
---DSSCQTIIPKIKLEPHEVDQFLNFSP------KEAPVDHLH------------------------------------
--------------------------------------------------------------------------------
------------------------------------LPPTPPSSHGSDSEGSLSPNPR----------------------
-LHPFSLPQTH-SPSRAAPRAPSALSSS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP
LSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRTLLQQLQKLQTLVMG
K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK--------
---------MALPSQHSLQEP----------------------------------------YTASVVRSRNLLIYEEHSP
PEEPSSPGSAGELGG----WDRGS-SLLRVS-GLESRP-----------------DVDLPHFIISNDTSLEKSVLLELQQ
HLVSAKLEGNETLKVVELDRRVNTTF------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Canis_familiaris_CREB3L2
--------------------------------------------------------------MEVLESGEQS------VL
QWDRKLSELSEPGETEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK
SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE
PRAQSP--------------------------FTHVTTSDSVNDDEVESE--------KWYLSTDFPSTTIKTEPITEEP
P---PGLVPSV-----------------------------------------TLTITAISTPCEKEEPPLEMN---PGV-
---DSSCQTIIPKIKLEPHEVDQFLNFSP------REASVEHLH------------------------------------
--------------------------------------------------------------------------------
------------------------------------LPPTPPSSHSSDSEGSLSPNPR----------------------
-LHPFSLPQTH-SPARAVARAPSALSNS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP
LTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRTLLQQLQKLQTLVMG
K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK--------
---------MALPSQHSVQEP----------------------------------------YTASVVRSRNLLIYEEHSP
LEEPLSPASAGELGH----WDRGS-SLLRAS-GLETRP-----------------DVDLPHFIISNETSLEKSVLLELQQ
HLVSAKLEGNETLKVVELDRRVNATF------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Myotis_lucifugus_CREB3L2
--------------------------------------------------------------LSVRESGWGCSFFM--VR
QWNKGCRDLCEYMYG-LFLYHLHGRHFSELLDEFS-QNVLGQLLNDPFLS----------------------------EK
SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLSEE
PRAQSP--------------------------FTHVTNSDSFNDDEVENE--------KWYLSTEFPSTTIKTEPITEES
P---PGLVPSV-----------------------------------------TLTITAISTPFEKEEPPLEMN---TGV-
---DSSCQTVIPKIKLEPHEVDQFLNFSP------KEASVDHLH------------------------------------
--------------------------------------------------------------------------------
------------------------------------LPPTPPSSHSSDSEGSLSPNPR----------------------
-LHPFGLPQTH-SPARAVPRAPSALSSS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLVLTEEEKRTLVAEGYPIPTKLP
LTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNRALLQQLQKLQTLVMG
K-VSRTCKLAGTQTGTCLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK--------
---------MALPSQHSMPEP----------------------------------------YTASVVRSRNLLIYEEHSP
LEEPSSPASAGELGR----WDRGS-SLLRAS-GLESRP-----------------DVDLPHFIISNESSLEKSVLWELQQ
HLAGAKLEGNETLKVVELDRRVNATF------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pteropus_vampyrus_CREB3L2
--------------------------------------------------------------MEVLESGEQS------VL
QWDRKLSELSEPGESEALMYHTH---FSELLDEFS-QNVLGQLLNDPFLS----------------------------EK
SVSMEVEPSPTSPAP----------------------------------------------------LIQAEHSYSLCEE
PRVQSP--------------------------FTHVTSSDSFNDDDVESE--------KWYLCTDFPSATIKTEPITDEP
P---PGLVPSV-----------------------------------------TLTITAISTPLEKVEPPLEMS---TGV-
---DSSCQTIIPQIKLEPHEVDQFLNFSP------KEASVDHLH------------------------------------
--------------------------------------------------------------------------------
------------------------------------LPPTPPSSHSSDSEGSLSPSPR----------------------
-LHPFGPAQTH-SPARAVVRAPSTLSSS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLVLTEEEKRTLIAEGYPIPTKLP
LTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEK-KVESCSTENLELRKKVEVLEN--TNXXXXQQLQKLQTLVMG
M-VSRTCKLAGTQTG-CLMVV----------------------------VLCFAVAFGSFFQGYGPYPSATK--------
---------MALPSQHSMPEP----------------------------------------YTASIVRSRNLLIYEEHSP
LEEPSSPASAGELGR----WDRGS-ALLRAS-GLEPRP-----------------DMDLPHFILANDTSLEKSVLLELQQ
HLVGTKLEGNETLKVVELDRRVNATF------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Danio_rerio_CREB3L2_a
--------------------------------------------------------------MEIMD-SGEPF------L
QWDKNLSELSEAGEND-ILYSTH---FTDLLDDLSQEALLGQLLSDPFLSGRG------------------------DAM
DTEE--ELTRASPVPP---------------------------------------------------HIQAEHSYSLCGD
SRPQSP--------------------------LSHLPGEPGSDAADSESD--------EWPMEQEDKGIKMEPLLCVPLP
A--LTLTVTPA-----------------------------------------GSAPEPVIDSCDSAQSLSLP--------
---QVKEDSNSPQIKLEPHEVDQFLNLSPK--------GLECLQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSVGSDSEGSQSPVH-----------------------
-PCAPASPTQTPAVLKVAPRAPSSLSSS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLLLTEEEKRTLIAEGYPVPTKLP
LSKAEEKALKKIRRKIKNKISAQESRRKKKEYVDALEK-KVETCSNENHELRRKVENLEC--TNKSLLQQLHSLQAVVAG
K-VPRSCRVTGTQTSTCLMVV----------------------------VLCFSLFLGSFYPG-LSPCSSITK-------
---------ADLS-REISIHD----------------------------------------SYTTTVKSRSLLSIQEPGG
LDEPHPIGLGGEYP--EWDRQADVMAAWRFEQQHKEEEA--------------ELHKAEHRPLLLSTNETHAQKAILIDL
HT---HRSNETA-KVIQLDRTVNETS------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Takifugu_rubripes_CREB3L2_b
--------------------------------------------------------------MEILD-STEPF------L
HWDRNLSELSDTEEIDSMLYTNH---FSELLDDLSQDALLGQLLSDPFLSGGRC---------------------GVEAM
EGEDSGDLSPSSPLPP---------------------------------------------------HITAEHSYSLCGD
SRPQSP--------------------------LSHLTGEQGSEAGESEGD------SADWPMEQEEAMDSLLCETPSLIP
T--LSLSLPQG-----------------------------------------PEGPAAASPAAAAALPAVAS-TSASSN-
---QIKEESVLPQIKLEPHEVDQFLNLSPK--------GLESLQ------------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPSSHGSDSEGSQSPVHA-PPGLS----------------
RPTSPTSPAPAQAALKTSPRASSCLSNS---PLLTAPHKLQG--------------------------------------
------------------------------------------------------SGPLILTEEERRTLVAEGYPVPTKLP
LTKAEEKALKKIRRKIKNKISAQESRRKKKEYMDTLEK-KVETCTNENSELRRKVENLDK--DNKSLLQQLQSLQDMVAG
K-LAKSCRVAGTQTSSCLMVV----------------------------MLCFALFLGSFYPGSFIPSSSITE-------
---------TGLASKQLTIKE----------------------------------------SYIATGFS-----------
-------------------------AACGRSD----------------------TLYFLFCTFRAKIEG----------L
PRGACTHSGKFQ-KM-----------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Strongylocentrotus_purpuratus_CREB3L2
------------------------------------------------------------MTDHLDGLSSPS--------
-------YYEYDYLFDDDPLLSADKMVSGEASDPTLPHIASEHSYS------------------------------MMSE
PNSPMMKDIK--------------------------------------------------------------QEDDLDSN
YDPEGL--------------------------QDMLPVSPETDDHHISLI---------SSDQHNNTTTTTTAGGLTTGY
LLMDKLTGAKS-----------------------------------------ILTTANRTSLTRNGELKPT-------TT
TLQQKQDGSKIKLELVTMMNVDNGLGSKH-----------------Q---------------------------------
--------------------------------------------------------------------------------
------------------------------------MPPTPPGSTASYSDSDGSESPG----------------------
----RSTPSSPRAVPIQPAKRPICHTRTVSPQLFTNIQKLPQ--------------------------------------
------------------------------------------------------SGPLHLTEEERRTLRQEGYPIPTKLP
LTKAEEKSLKKVRRKIKNKISAQESRRKKKEYLEALEK-RMDSYTSENTELKRKVENLEN--TNQSLSSQLSKLQSIVN-
K-ISKPIKAHTTQTGTCLMV----------------------------LVLCFAVFLGSWTPHSFLSSNQ-HL-------
---------PKLFSSSSSPNNDMPHPFFGPYGNNIQYSAPSFHGDDGEDQPDPIFRMYGPKPASGSEDDDPYTTHSMRSS
RTLLSYQDEEDAFAGIDPHYHDDSHALLDNIAPEAPSFA--------------KMAAALMTGLGSEVAGVESEETGYEAY
MMHPDMEAKIIPVDTMALINRSSNK-------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Homo_sapiens_CREB3L3
--------------------------------------------------------------------------------
--------------MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQ--------------------------------D
GILRHVELGEG-------------------------------------------------------WGHV-KDQQVLPNP
DSDDF---------------------------LSSILGSG-DSLPSS----------PLWSP-EGSDSG-ISEDLPSDPQ
DT-------------------------------------------------------------------------PPRSG
--PATSPAGCHPAQPGKGPCLSYHPG------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------NSCSTTTPGPVIQVPEASVTIDL----------EMWSPGGRICAEK
PADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPG---------------------------------------
---------------------------------------------------AGHCQELVLTEDEKKLLAKEGITLPTQLP
LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ
STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN-------------
--------KTESPGDFAPVRVFS--------------------------------------RTLHNDAASRVAADAVPGS
EAPGPRPEADTTREE----SPGSPGADWG-FQDTANL---------------TNSTEELDN---ATLVLRNATEGLG-QV
ALLDWVA--PGPSTGSGRAGLEAAGDEL----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pan_troglodytes_CREB3L3
--------------------------------------------------------------------------------
--------------MNMDLAAGKMASAACSMDPIDSFELLDLLFDRQ--------------------------------D
GILRHVELGEG-------------------------------------------------------WGHV-KDQQVLPNP
DSDDF---------------------------LSSILGSG-DSLPSS----------PLWSP-EGSDSG-ISEDLPSDPQ
DT-------------------------------------------------------------------------PPRSG
--PATSPAGCHPAQPGKGPCLSYHPG------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------NSCPTTPPGPVIQVPEASVTIDL----------EMWSPGGRICAEK
PADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPG---------------------------------------
---------------------------------------------------AGHCQELVLTEDEKKLLAKEGITLPTQLP
LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ
STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN-------------
--------KTESPGDFAPVRVFS--------------------------------------RTLHNDAASRVAADAVPGS
EAPGPRPEADTTQEE----SPGSPGADWG-FQDTANL---------------TNSMEELDN---ATLVLRNATEGLG-QV
PLLDWVA--PGPSTGSGRAGLEAAGDEL----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Gorilla_gorilla_CREB3L3
--------------------------------------------------------------------------------
--------------MNTDLAAGKMASAACSMDPIDSFELLDLLFDRH--------------------------------D
GILRHVELGEG-------------------------------------------------------WGHV-KDQQVLPNP
DSDDF---------------------------LSSILGSG-DSLPSS----------PLWSP-EGSDSG-ISEDLPSDPQ
DT-------------------------------------------------------------------------PPRSG
--PATSPAGCHPAQPGKGPCLSYHPG------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------NSCSTTPPGPVTQVPEASVTIDL----------EMWSPGGKICAEK
PADSVDLSPRCNLTVKDLLLSASSGDLQQHHLGTSYLLRPG---------------------------------------
---------------------------------------------------AGHCQELVLTEDEKKLLAKEGITLPTQLP
LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ
STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN-------------
--------KTESPGDFAPVRVFS--------------------------------------RTLHNDAASRVAADAVPGS
EAPGPRPEADTTREE----SPGSPGADWG-FQNTANL---------------TNSTEELDN---ATLVLRNATEGLG-QV
ALLDWVA--PGPSTGSGRAGLEAAGDEL----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Macaca_mulatta_CREB3L3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------QQHHLGVSHLLRPG---------------------------------------
---------------------------------------------------AEHCQELVLTEDEKKLLAKEGITLPTQLP
LTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ
STSK------SAQTGTCVAVLL----------------------------LSFALIILPSISPFGPN-------------
--------KAESPGDFAPVRVFS--------------------------------------RTLHNDAASRVTSDAVPGS
EAPGPQPEADTTQEG----SPGIPGADWD-FRDSANL---------------TNSTEEVDN---ATLILRNATEGLG-QV
TLLDWVA--PGPSTGSGRAGLEAAGDEL----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Canis_familiaris_CREB3L3
--------------------------------------------------------------------------------
--------------VNGDLAAGKMASSVGPLDPIGSLELLDLLFDQQ--------------------------------D
GILRHVELGED-------------------------------------------------------WDHV-GDQQVLPGP
DSDDF---------------------------LNSILAPG-DSVPSS----------PIWSP-AASDSG-ISEDLPSDPQ
DT-------------------------------------------------------------------------PPRSA
--AAATPAGCHALESGKGLCASYHPG------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------PPCLAGGPGPATQALEASVAIDL----------EMWSSG--LGSEE
LGELAGPPPCCSLTVKDLLLSGSGADLQQHHLAAPHLLRPG---------------------------------------
---------------------------------------------------PEQCQELVLTEDEKKLLAKEGITLPTQLP
PSNYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ
STSK------SAQTGTCLAVLL----------------------------FSFALIVLPSISPFVAN-------------
--------KAKHAGDYAPVRVFS--------------------------------------RTLHNDPASRVAPDAIPGS
EAPGPRPKGGTPQEG----SPGSPVADWE-SR-TSAL---------------DNWTKGLDNN--ATLILGNDSEKLNPPA
TLLGWTA--PEPTLSSGRVGLEAAGEEL----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Felis_catus_CREB3L3
--------------------------------------------------------------------------------
--------------MNGDLAAGKMASSTGPMGPIGSLELLDLLFDHQ--------------------------------D
GILRHVELGED-------------------------------------------------------WGHL-EDQQSTSFP
DSDDF---------------------------LNSILASG-DSVPSS----------PIWSP-AASDSG-ISEDLPSDSQ
DT-------------------------------------------------------------------------PPRSG
--AATTPAG----------CPPYHPG------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------APCLAGPPGPVAQVLDASVAIDL----------EMWSQG--LRREE
RAELADLPLSCSLTVKDLLLSGGGGDLQQHHPGAPHLPRPA---------------------------------------
---------------------------------------------------TQHCQELVLTEDEKKLLAKEGLTLPTQLP
LTKYEERALKKIRRKIRNKQSAQESRKKKKEYIDGLET-RMSACTAQNQELQRKVLHLEK--QNLSLLEQLKKLQAIVVQ
STGK------SAQTGTCIAVLL----------------------------FSFALIVLPSISPFVAN-------------
--------KAESAGDYAPVRVFS--------------------------------------RTLHNDAASRVAPDATPGS
EVPGPRPKAGASQEG----SPGSPRADWE-SQGKSAL---------------DNLTEELDN---STLIADNSTEKLN-RA
TLLDWTA--PEPALSPGRGGLEAAGEEL----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Gasterosteus_aculeatus_CREB3L3_a
--------------------------------------------------------------------------------
------------------------MEPYQ-DEGCDGIELLDWLFDQN--------------------------------E
GILRHEETGRHGNH--------------------------------------------------HAWPVQDPSMPP----
ADDDF---------------------------LNALLRGSSGSASGS----------PLWAS-SPSDSG-ISEDPPSDQM
DS-------------------------------------------------------------------------PRRPE
SPNGDARCFGARPRTKAGLEATASADL-----------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------DGWQAAFPAGRTG---ITQCPLD-----------------------
-AHRAQMPSGFALTVKDLLLSGTQEP--------PPHPPHQ---------------------------------------
---------------------------------------------------S--IQELILNEDEKKLLAKEGVSLPGQLP
LTKYEERILKKIRRKIRNKQSAQESRKKKKEYIDGLES-RMAACNAHNHELQRKVSQLQK--CNMSLKEQLRRLQAMVMS
SSHK------PAQAGTCVLVLL----------------------------LSFSLILFPSLKPFSDA-------------
--------KVSQ-GDFSPVRIQS--------------------------------------RSLQNLQASRVLHVTE--F
PAEDEVEPLHRHVPGRR------DVEDITAVMEKLGV---------------SPERPDAEPVAVNSSRQERVVDDFHVDP
ITGHIAS---LTLDPRRSARLRPHADDM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Homo_sapiens_CREB3L4
--------------------------------------------------------------------------------
------------------------MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHC-------------------PPPEV
PVTRLQEQGLQGWK--------------------------------------------------SGGDRG----CGLQES
EPED----------------------------FLKLFIDPNEVYCS--------------EASPGSDSG-ISEDPCHPDS
PP-------------------------------------------------------------------------APRAT
---SSPMLYEVVYEAGALERMQGETGPNV---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GLISIQLDQWSPAFMVPD------------------------
-----------SCMVSELPFDAHAHILPRAGTVAPVPCTTL---------------------------------------
---------------------------------------------------LPCQT-LFLTDEEKRLLGQEGVSLPSHLP
LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVAQLRQLQTLIAQ
TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQSR-------------
--------PEAGSED-YQPHG----------------------------------------VTSRNILTH----------
----------------------------KDVTENL-------------------------ETQVVESRLREPPGAKDANG
STRTLLEKMGGKPRPSGRIRSVLHADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pan_troglodytes_CREB3L4
--------------------------------------------------------------------------------
------------------------MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHC-------------------PPPEV
PVTRLQEQGLQGWK--------------------------------------------------SGGDRG----CGLQES
EPED----------------------------FLKLFIDPNEVYCS--------------EASPGSDSG-ISEDPCHPDS
PP-------------------------------------------------------------------------APRAT
---SSPTLYEVVYEAGALERMQGETGPNV---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GLISIQLDQWSPAFMVPD------------------------
-----------SCMVSELPFDAHAHILPRAGTVAPVPCTTL---------------------------------------
---------------------------------------------------LPCQT-LFLTDEEKRLLGQEGVSLPSHLP
LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVAQLRQLQTLIAQ
TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQSR-------------
--------PEAGSED-YQPHG----------------------------------------VTSRNILTH----------
----------------------------KDVTENL-------------------------ETQVVESRLREPPGAKDANG
STRTLLEKMGGKPRPSGRIRTMLHADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Macaca_mulatta_CREB3L4
--------------------------------------------------------------------------------
------------------------MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHC-------------------PPPEV
PVTRLQEQGLQGWK--------------------------------------------------SGGDHG----CGLQES
EPED----------------------------FLKLFIDPNEVYRS--------------EASPGNDSG-TSEDPCRPDS
PP-------------------------------------------------------------------------APRAT
---SSPTLYEVVYEAGALERMQGETGPTV---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GLISIQLDQWSPAFMVPD------------------------
-----------SCMVSELPFDAHAHILPRAGTLAPVPCTTL---------------------------------------
---------------------------------------------------LPCQT-LFLTDEEKRLLGQEGVSLPSHLP
LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVAQLRQLQTLIAQ
TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQGR-------------
--------PEAGPED-YQPHG----------------------------------------VTSRNILTH----------
----------------------------KDITENL-------------------------ETQVVESRLREPPEAKDAND
STRTLLEKMGGKPRPSGRIGTVLHADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Mus_musculus_CREB3L4
--------------------------------------------------------------------------------
------------------------MELGCPELL----EPPEDIFSTGSFLELGFNG-------------------PASKV
PVTR-----------------------------------------------------------------------GLQKS
EPDD----------------------------FLNLFIDPNMIHCS--------------ETSPGRDSG-VSEDPG----
SP-------------------------------------------------------------------------AQQAS
---SSPALYEVVYDSGTLQGTQREAGPTF---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GLISIQIDQWTPALMVPD------------------------
-----------ACTVSGLPSDSHRHILPRVSTRAPAPPAAM---------------------------------------
---------------------------------------------------PSCQHHLFLTDEEKQLLAQEGITLPSHLP
LTKAEERILKKIRRKIRNKQSAQDSRRRKKEYLDGLES-RVAACSEQNQKLQRKVQELER--QNIFLMEQVRQLQKLTAQ
TSSR------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQGQ-------------
--------SEARPED-YQLHG----------------------------------------VISRNILTH----------
----------------------------ENVTENL-------------------------ESPVLKSKLEELPEAPTTNG
STKT-HLKMRVKARPPGQIRGMVHTDEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Rattus_norvegicus_CREB3L4
--------------------------------------------------------------------------------
------------------------MELGCPELL----EPPEDIFSTGSFLELGFNG-------------------PPSK-
---------------------------------------------------------------------------GLQKS
ESDD----------------------------FLNLFIDPNMIRCS--------------ETSPGSDSG-VSEDPG----
SP-------------------------------------------------------------------------APQAP
---SSPALYEVVYEAGALQGTQREAGPTF---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GLISIQIDQWSPAFMVPG------------------------
-----------ACTVSDLPSEAHRHILPRVSTIAPPPPAAL---------------------------------------
---------------------------------------------------LSCQR-LFLTDEEKHLLGQEGVTLPSHLP
LTKAEERILKKIRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSEQNQKLQRKVQELER--QNISLVAQVHQLQKFTAQ
TSSR------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQSQ-------------
--------PEARSEG-YQLHG----------------------------------------VISRNILTH----------
----------------------------EDMTESP-------------------------ESPVLKANLEELPQVPATNG
STKMAHLKMRVKARPTGPIRGMVHADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Canis_familiaris_CREB3L4
--------------------------------------------------------------------------------
------------------------MDFRAPGLLDQWLEPPEEVFSAGAFLELGPPC-------------------PHAEA
PGTP--EQGLPGNW--------------------------------------------------AVQGRGESGSGGLQES
EPED----------------------------FLKLFIDPNEVYCS--------------QASPGSDSG-ISEDPGHPDG
PR-------------------------------------------------------------------------APKAP
---SSPAVCEVVFEAGVLQRMEGPPG------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------RLISVHLDQWNPPLPVPE------------------------
-----------ACMVCELPLDAHTHTLPRAGSVNPVPPATL---------------------------------------
---------------------------------------------------LPCQT-VFLTEEEKRLLGQEGVSLPTHLP
LTKAEERVLKKIRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSAQNQELQKKVQELER--HNISLVTQLRQLQTLIAQ
TSNK------AAQTSTCVLILL----------------------------FSLALIVLPSVSPLQGL-------------
--------REAGSED-YQPHG----------------------------------------VISRNILTH----------
----------------------------KDMIENL-------------------------ETTVVESRLEGPPRTKDVNG
STRTLLEKMGGKTGPGGHIRTVLHADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Felis_catus_CREB3L4
--------------------------------------------------------------------------------
------------------------MDFRTPDLLDAWLESPEDVFSTGTFPEPGLHG-------------------PPPEA
PGTKLQEQGLRGWE--------------------------------------------------PSGGRG----CGLRDS
EPED----------------------------FLKLFIDPNEVYCS--------------GASASSDSGHPSADPGRPDR
PP-------------------------------------------------------------------------APQAP
---SPPALYEVVYEAGALERTQGEAGPAV---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GFISLQPGQRSPQLTVPD------------------------
-----------ACVVCELPCDAH-DTLPGAGTVNPVPPATL---------------------------------------
---------------------------------------------------LPCQT-LFLTEEEKRLLGQEGVSLPAHLP
LTKAEERVLKKVRRKIRNKQSAQDSRQRKKEYIDGLES-RAAACSAQNQELQKKVQELER--CNVSLVAQLRQLQLLAAR
TSDK------AAQTSTCVVILL----------------------------FSLALIILPSVSPFQGL-------------
--------REAGPED-YQPHGAT--------------------------------------VVSRNILSH----------
----------------------------KDMTEGL-------------------------ETTVVESRPGGPLKAKGENG
STRTLLEKMGGKTGSNGHAGAVLHAEEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Myotis_lucifugus_CREB3L4
--------------------------------------------------------------------------------
------------------------MDFGTPDLLDVWLEPPDDVL-TGPFLELGLHC-------------------PPPEV
PVTMLQEQGLQGWE--------------------------------------------------SSGAPA----CGLQES
EPED----------------------------FPKLFIDPNEVYCS--------------EASPGSDSG-ISEHPGRRDS
PP-------------------------------------------------------------------------VPQAP
---SSPALYEVVYETEALEKMQEEAGPAV---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GFISIQLDQWSPPFMMPD------------------------
-----------ACMVSNVPLDAHAHILPRAGTVNPVLPATL---------------------------------------
---------------------------------------------------LPCQA-LFLTDEEKHLLGQEGISLPSHLP
LTKTEERVLKKVRRKIRNKQSAQDSRRRKKEYIEGLES-KVAACSAQNQQLQKKIQELER--HNVSLVTQLRQLQMLITQ
TSNK------AAQTSTCVLILL----------------------------FSLALIILPSFSPFQGP-------------
--------PEAGSED-YQPHG----------------------------------------VISRNILIH----------
----------------------------KDVTKNW-------------------------ETPEVESRLGGPPGIKSANG
STTTLLEKTGGKTGPRGLLRTVLHADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Pteropus_vampyrus_CREB3L4
--------------------------------------------------------------------------------
-------------------------DFGTPDLLDVWLEPPEDVFSTGSFLELGLHC-------------------PPPEA
PVTRMQEQGLQGWE--------------------------------------------------STGGRG----RGLQES
EPED----------------------------LPKLCIDPNEVYCS--------------EASPGSDSG-LSEDPGRPDS
PP-------------------------------------------------------------------------APKAP
---SSPALYEVIYEAGALERMQGEARPAV---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------GLISIQLDQWSPPFMVPE------------------------
-----------ACVVSELPLDARVHLLPPAGAVSPVPPSTL---------------------------------------
---------------------------------------------------LSCQA-LFLTDEEKRLLGQEGVSLPSHLP
LTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLES-RVAACSVQNQELQKKVQELER--HNISLVTQLRQLQMLMTQ
TSNK------AAQTSTCVLILL----------------------------FSLALIILPSLSPFQGL-------------
--------PEARPKD-YQPHG----------------------------------------VISRNILTH----------
----------------------------KDMMENQ-------------------------ETPVAESRLGGPPGAKGANG
STRTLLEKMGGKTGPGGHVRTTVHADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Takifugu_rubripes_CREB3L4_a
--------------------------------------------------------------------------------
------------------------MNADSRELSLGSSEDETQTLFSCSDLIFSSEE-------------------KSLLD
WAVEP----------------------------------------------------------------------DCALN
DSETE---------------------------DFLHAVDPNEVFPRG----------PPMALSSESDCS-LSEDPPVVSP
VT-------------------------------------------------------------------------MVTTP
--VEPATVYQVVYDLSGLGTVKPEPGQENV--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------VSIELADDW-ASKVLISD------------------------
-----------SCIVGELPVFSTAHVNPPS---PDGNLVRL---------------------------------------
---------------------------------------------------LSFYAELQLTEEEQKLLSQEGVSLPTNLP
LTKAEERVLKRIRRKIRNKQSAQDSRRRRKEYIDTLES-RAAACSAQNKELQRTVEHLEK--RNMSLLMQLRQLQSLIKQ
TVSK------GAQTSTCLLIIL----------------------------LSLALIIMPSFSPFR-R-------------
--------SWSSDD--FRPIG----------------------------------------VLSRNILTDSASWRTVVDD
VD--------------RR----ADSEVRQTGPADVSE---------------PTQVPENRTQDGGQSAPASPPRQTEPPA
LDSAAAAGAKR----SHNATKAGRADEM----------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------
>Oryzias_latipes_CREB3L4_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------MLS
DS-----------------------------------------------------------------CP-L---IPVAGP
G-----------------------