>Human_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MGSS-ATEIEELENT------------------------------------TFKYLT-----------
--------------------------------------------------------------------------------
------------------------GEQTEKMWQRLKGILRCLVKQLE-RGDVNVVDLKKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPK--FRSIVHAVQAG
IFVERMYRKTYHMVGLAYPAAVIVTLKD------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIT
FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EEMNILINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-IDRA
KTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
SLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIV-------------GLHIADALRRSNTKGSMSDGSYSPDYSLAAVD
LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ESDLHKNSEDLVNA--EEKHDETHS
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Mouse_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MGST-DTDIEELENA------------------------------------TYKYLI-----------
--------------------------------------------------------------------------------
------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNVVDLKKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKPEEKPK--FRSIVHAVQAG
IFVERMYRKNYHMVGLTYPAAVIVTLKE------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIA
FAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EEMNILVNLSKDDW--RDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPEG-IDRA
KTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
SLLTDSTEKIVIPLIEEASKSQSSNYGASSSSTMI-------------GFHVADSLRRSNTKGSVCDGSYAPDYSLSAVD
LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ELDLHKNSEELGNT--EEKHADTRP
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Rat_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MGST-DTDIEELENA------------------------------------TYKYLI-----------
--------------------------------------------------------------------------------
------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNVVDLKKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPK--FRSIVHAVQAG
IFVERMYRKNYHMVGLTYPAAVIVTLKE------VDKWSFDVFALNEASGEHSLKFMIYELFTSNDLINRFKIPVSCLIA
FAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAVHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EEMNILVNLSKDDW--RDLRNLVIETVLATDMSGHFQQIKNIRSSLQQPEG-IDRA
KTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
SLLTDSTEKIVIPLIEEASKPESSNYGASSSSTMI-------------GFHVADALRRSNTKGCMSDGTYAPDYSLSAVD
LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ELDLHKNSEDL-----EEKHADTHP
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Cow_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MD----------DHV------------------------------------TIR--------------
--------------------------------------------------------------------------------
----------------------------RKHLQRPIFRLRCLVKQLE-KGDVNVIDLKKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPR--FRSIVHVVQAG
IFVERMYRKSYHMVGLAYPEAVIVTLKD------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIA
FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EEMNVLINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-LDKA
KTMSLILHAADISHPAKSWKLHHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
SLLTDSTEKIIIPLIEEDSKTKTPSYGAS---------------------------RRSNMKGTTNDGTYSPDYSLASVD
LKSFKNSLVDIIQQNKERWKELAAQG-----------------------------EPDPHKNS-DLVNA--EEKHAETHS
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Dog_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MD----------DHV------------------------------------TIR--------------
--------------------------------------------------------------------------------
----------------------------KKHLQRPIFRLRCLVKQLE-RGDVNVVDLKKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKSEEKPK--FRSIVHAVQAG
IFVERMYRKSYHMVGLVYPEAVIVTLKD------VDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIS
FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA
LLYNDRSVLENHHVSAAYRLMQE-EEMNVLINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-IDKA
KTMSLILHAADISHPAKSWQLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
SLLTDSTEKIIIPLIEEASKTDTSSYGAS---------------------------RRSNMKGTMNDGTYSPDYSLASVD
LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------EPDLHKNSEDLVNA--EEKHVDTHS
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Horse_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MGST-AADTEELENT------------------------------------TFKYLI-----------
--------------------------------------------------------------------------------
------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNIVDLKKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMKKKKSEEKPK--FRSIVHAVQAG
IFVERMYRKSYHVVGLAYPEAVIVTLKD------VDKWSFDVFALNEASGEHSLKFIIYELFTRYDLINRFKIPVSCLIA
FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EEMNVLINLSKDDW--RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEG-IDRA
KTMSLILHAADISHPAKSWQLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
SLLTDSTEKIIIPLIEEDSKTENPSYGASRFGTFM-------------G?HVADLFRRSNIKGTMNDGTYSPDYSLACVD
LKSFKNNLVDIIQQNKERWKELAAQG-----------------------------ESDLHKNSEDLANA--EEKHADIHS
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Platypus_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MGST-ATELEEYGST------------------------------------SLKYLI-----------
--------------------------------------------------------------------------------
------------------------GEQTEKMWQRLKGILRCLVKQLE-KGDVNVVDLKKNIEYAASVLEAVYIDETRK--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDSVPLEVRDWLASTFTRKMGMAKKKTEEKPK--FRSIVHAVQAG
IFVERMYRRTSNMAGLAYPAAVIVTLKD------VDKWSFNVFALNDASGEHSLKFMMYELFTRYDLISRFKIPVSCLIS
FAEALEVGYSKFKNPYHNLIHAADVTQTVHYILLHTGLMHWLSELEILAMVFAAAIHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EDMNILTNLSKDDW--RELRGLVVEMVLSTDMSGHFHQIKTMRNTLQQPEG-VDKG
KAMSLILHAADISHPAKSWDLHHKWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
SLLTDSTERIVVPLIEESCRSESSCLPCSPSPTSQNSDG---------GLTATDTQKKPSGKLTSNEGPSSSNYSLASVD
LKSFKNNLVDIIQQNKERWKELALQERVL------------------------RSDRKLKKKHRPAPGAKLEDKGSSSDS
KDIKESSGGQSLMGASAPDPAANPSGSRPQLWLKSGPIPRPDGDDGDIEIERHFLSSSQVEEVFM---------------
--------------------------------------------------------------------------------
---------------
>Zebrafinch_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------MTQDQ-----------
--------------------------------------------------------------------------------
------------------------QDTCALLEQQLATRLRCLVKQLE-KGDINVVDLKKNIEYAASVLEAVYIDETRK--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDSVPLEVRDWLASTFTREMGIVKRRPEEKPK--FRSIVHAVQAG
IFVERMYRKTSSMVGLAYPAEVIVTFKD------VDKWSFDVFALNEASGEHSLKFMMYELLTRYDLLSRFKIPVPNLIS
FAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMIHTGIMHWLTELEILAMIFAAAVHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EEMNILANLNKDDW--RELRSLVIEMVLSTDMSGHFQQIKTMRHTLQQAQG-VDKA
KAMSLILHAADISHPAKSWELHYRWTMALMEEFFRQGDKEAALGLQFSPLCDRKSTLVAQSQIG------FIDFIVEPTF
SLLTDSMEKIVMPLIEEATKSESPAFGTPSQNSLG-------------AVSNAEAQRRPGFKSTG-DGGTHTENSLATVD
LRGFKDNLMKIIQANKERWKELAAEGEPKHCKS-----------------------EDIVKATEQ---------TEALVQ
N-------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Chicken_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------MTQDL-----------
--------------------------------------------------------------------------------
------------------------QDTCALLEQQLGTRLRCLVKQLE-KGDINVVDLKKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDSVPLEVRDWLASTFTREMGIVKRRPEEKPK--FRSIVHAVQAG
IFVERMYRRTSSMVGLAYPAEVIVTFKD------VDKWSFDVFALNEASGEHSLKFMMYELFTRYDLLNRFKIPVPNLIT
FAETLEVGYSKYKNPYHNLIHAADVTQTVHYILIHTGIMHWLTELEILAMIFAAAIHDYEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRLMQE-EEMNILANLTKDDW--RELRSLVIEMVLSTDMSGHFQQIKTMRHTLQQAEG-VDKA
KAMSLILHAADISHPAKSWELHYRWTMALMEEFFRQGDKEAALGLQFSPLCDRKSTLVAQSQIG------FIDFIVEPTF
SLLTDSMEKIVMPLIEEASKSESPAFGTPGQNNLG-------------AVSNVDAQRRHNFRSTASDGAAHTENSLATVD
LRSFRDNLMQIIQANKERWKELAVEVRYKLLMVSVTVGSGGKGISLEIPVYLMPSEEELVKNVDEQEKDQSRNSTDAQLQ
EETRSRQNESSQGSGGTACPPRPIVLQVVTSNTSLSDESNSEKCTNSDPNQKDLTDAQQETQNTDPLNDTSVKLLYTAVC
--------------------------------------------------------------------------------
---------------
>Anolelizard_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MGSTGTERNEGMDSA------------------------------------LLKYPI-----------
--------------------------------------------------------------------------------
------------------------RGHTEKMWQRLKGILRCLVKQLE-KGDVNIIDLKKNIEYAASVLEAVYIDETRK--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTDDELSDMRTDSVPMEVRDWLASTFTRKMGMTKRRPEEKPK--FRSIVHAVQAG
IFVERMYRRTSSMVGLAYPSEVITTFKD------VDKWSFDVFALNEASGGHSLKFMMYELLIRYDLVSRFKIPVPSLIS
FAETLENGYSKHRNPYHNLIHAADVTHTVHCILLLTGIMHWLTELEILAMIFAAAIHDYEHTGTTNNFHIQTRSD---VA
MLYNDRSVLENHHVSAAYKIMQE-DEMNILLNLSKDEW--RELRTLVIEMVLSTDMSGHFQQIKTIRHTLQETEG-IDKA
KAMSLILHAADISHPSKTWNLHFRWTKALMEEFFQQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVKPTF
ALLTDSMEKIVLPLIVEASKSETSTITSRKTVNMG-------------GLHFKQKYHHLEVQKKL-TIKTSTCSGLSAVD
LNRFKEDLFQIVQENKDRWKDLAEKG------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Frog_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MEST-AFESEDPEYP------------------------------------SSNFET-----------
--------------------------------------------------------------------------------
------------------------RESNDKMVQRLQGILRCLVKQLE-KGDINVTDLKNNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIHTDSVPLEVRDWLASTFTRKMGMRKRRPEEKPK--FRSIVHAVQAG
IFVERMYRRSSNIAGLTYPSSVIASMKD------VDRWAFNVFTLNEASGEHALKFMVYELFTRYDLTNRFKIPVSNLVS
FVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGIMHWLTELEILAMIFAAAIHDFEHTGTTNNFHIQTRSD---VA
ILYNDRSVLENHHVSAAYRIMQD-DEMNIFINLSKDDW--RDLRTLVIEMVLSTDMSGHFQQLKTMRSTLQQPEG-IDKA
KAMSLILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
TLLTDSTEKIVFPLIEEAAKSDNSVFDKSSQNNSE-------------VVRGTDTPRKPSVRTSQMDGSSPSEYSLATVD
LHHFKKNLVEIIQQNKERWKELAAQE------------------------------RNLKSTHKSEGGT------GGT--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Zebrafish_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MDED-----------
--------------------------------------------------------------------------------
------------------------VTIKRKLLHRPIFRLRCLVKQLD-KGEVNVVDLRKNIEYAASVLEAVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMAGLTYPPSVITALKD------VDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIPVSSLVS
FVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAAAIHDFEHTGTTNNFHIQTRSE---VA
ILYNDRSVLENHHVSAAYRLMQE-DEMNILVNLSKDDW--RELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEG-IDKA
KALSLMLHAADISHPAKGWKLHYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIG------FIDFIVEPTF
SVLVDTTEKIISPLIEEAVKS--GGVRRSSLTGRGS-------------AAVVESVQRHSDRGSNDECGGSTDYSLCGID
QKHVRHLLSEIIQNNKERWKELSVQGLTQI-------------------------SLSLHTASQKTGHSQLANKQHERMS
DLQEEPMRSTQLTLSQENHDSESKSLNELNNTDSTHSSQDSLDQSSQSPTEGAGDASPEEHSSETLPWNGKSA-------
--------------------------------------------------------------------------------
---------------
>Medaka_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------LYSS--HQLIIIICT------------------------------------QVFKYI-----------
--------------------------------------------------------------------------------
------------------------HLQKRRKIMTGILMLKAALEQMD-RGVVDLQELRRNLELAAAMLDAVYTDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDLQAESVPSEVRDWLACTFSRRTGLSKRRPEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMAGLTYPPTALNALKE------VDQWSFDVFTFHDATGEHALKFIVYDLLTRYDLINRFRIPVQALVQ
FVEALESGYSKHRNPYHNLIHAADVTQTAHFLMLHTGLMHWLSELEILAMVFAAAIHDFEHTGTTNNFHIHTRSE---VA
ILYNDRSVLENHHVSAAYKLMAE-EDMNILVNLNKDDW--RELRSLVIEMVMSTDMSCHFQQIKTMRNSLTQTDS-IDKV
KVLSLMLHAADISHPAKAWPLHYHWTHSLMEEFFRQGDKEVELGLPFSPLCDRKATMIAQSQIG------FIDFIVEPTF
SVLIDTTDKVIGPLIEEDRKARETGNRRPSLTGSG--------------SVTVESVQRHSSGLHGNSDDGPTDFSLTAID
LPALRLHLSSVIVSNKERWKELSVHG-----------------------------KYTVHKSS---------------LS
LLQ-------QAQISKATHH------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Stickleback_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------STSLKYLQ-----------
--------------PEQIEKIWLR--------------------------------------------------------
-------------------------LRGLRKYKKTSQRLRCLVKQLE-RGEASLTDLKKNLEYAALVLESVYIEETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPPSVISVLKH------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISAVVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA
ILYNDRSVLE-HHVSAAYRLLQEDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKTMKNFLQQPEG-IDKP
KALSLLLHTADISHPAKSWNLHHRWTTSLLEEFFRQGDKESELGLPFSPLCDRKSTMVAQSQIG------FIDFIVVPTF
TVLTDMMESIVKPLIDEASHAGFSGFRRS--SLNS---------------ISSEEAKRHSVKS--SDSSSSGHSSLLTVD
LKNFKALWNEEVYQNRERWKAQAAKEA----------------------------EERAKREAEEQAQQEEAME------
---PQEAHTEPE--------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Tetraodon_PDE1A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------LRCLVKQLE-RGEASLNDLKKNLEYAASVLESVYIEETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPPSVISVLKN------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA
ILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKAMKNFLQQPEG-IDKP
KALSLLLHTADISHPAKNWDLHHHWTTSLLEEFFRQGDKEADLGLPFSPLCDRKSTMVAQSQIG------FIDFIVVPTF
TVLTDMMERIVTPLIDEASHSGFSGFRRSRHSLNS---------------ISSEEAKRQSVKSMGSDSSSSGPSSLLTVD
IKNFKHVD-EEVYQNRERWKAQACKGE----------------------------REQEQRCGCYLHR------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Human_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MELSPRSPPEMLEESDCPS--------------------------------PLELKS-----------
--------------------------------------------------------------------------------
-------------------------APSKKMWIKLRSLLRYMVKQLE-NGEINIEELKKNLEYTASLLEAVYIDETRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------ILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPK--FRSIVHAVQAG
IFVERMFRRTYTSVGPTYSTAVLNCLKN------LDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMS
FLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA
IVYNDRSVLENHHISSVFRLMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKTMKTALQQLER-IDKP
KALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF
SVLTDVAEKSVQPLADEDSKSK----------------------------------NQPSFQWRQPSLD--VEVGDPNPD
VVSFRSTWVKRIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPPSPAEDEHNQNG
NLD-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Mouse_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS-----------
--------------------------------------------------------------------------------
-------------------------APSKKMWIKLRSLLRYMVKQLE-NGEVNIEELKKNLEYTASLLEAVYIDETRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------ILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK--FRSIVHAVQAG
IFVERMFRRTYTSVGPTYSTAVHNCLKN------LDLWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMS
FLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA
ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--AELRALVIEMVLATDMSCHFQQVKTMKTALQQLER-IDKS
KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF
SVLTDVAEKSVQPLADDDSKPK----------------------------------SQPSFQWRQPSLD--VDVGDPNPD
VVSFRATWTKYIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPSSPAEDEHNQNG
NLD-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Rat_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS-----------
--------------------------------------------------------------------------------
-------------------------APSKKMWIKLRSLLRYMVKQLE-NGEVNIEELKKNLEYTASLLEAVYIDETRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------ILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK--FRSIVHAVQAG
IFVERMFRRTYTAVGPTYSTAVHNCLKN------LDVWCFDVFSLNRAADDHALRTIVFELLTRHSLISRFKIPTVFLMS
FLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA
ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKTMKTALQQLER-IDKS
KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF
SVLTDVAEKSVQPLTDDDSKSK----------------------------------SQPSFQWRQPSLD--VDVGDPNPD
VVSFRSTWTKYIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPSSPAEDEHNQNG
NLD-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Cow_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS-----------
--------------------------------------------------------------------------------
-------------------------APSKKMWIKLRSLLRYMVKQLE-NGEVNIEELKKNLEYTASLLEAVYIDETRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------ILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGP-SEEKPK--FRSIVHAVQAG
IFVERMFRRTYTSVGPTYSTAVLNCLKN------VDLWCFDVFSLNRAADDHALRTIVFELLTRHNLISRFKIPTVFLMT
FLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA
ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKSMKTALQQLER-IDKS
KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF
SVLTDVAEKSVQPTGDDDSKSK----------------------------------NQPSFQWRQPSLD--VEVGDPNPD
VVSFRSTWTKYIQENKQKWKERAASGITN------------------------QMSIDELSPCEEEAPASPAEDEHNQNG
NLD-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Horse_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MELSPRSPPEML-ESDCPS--------------------------------PLELKS-----------
--------------------------------------------------------------------------------
-------------------------APSKKMWIKLRSLLRYMVKQLE-SGEVNIEELKKNLEYTASLLEAVYIDETRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------ILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPK--FRSIVHAVQAG
IFVERMFRRTYTSVGPTYSAAVLNCLKN------LDLWCFDVFSLNRAADDHALRTIVFELLTRHNLISRFKIPTVFLMT
FLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIEILAIIFAAAIHDYEHTGTTNSFHIQTKSE---CA
ILYNDRSVLENHHISSVFRMMQD-DEMNIFINLTKDEF--VELRALVIEMVLATDMSCHFQQVKSMKTALQQLER-IDKS
KALSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIG------FIDFIVEPTF
SVLTDVAEKSVQPQADEDSKSK----------------------------------NQPSFQWRQPSLD--VEVGDPNPD
VVSFRSTWTKYIQENKQKWKERAASGITN------------------------QMSIDELCPCEEEAPSSPAEDEHNQNG
NLD-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Frog_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------ME-SPSVDKDLL--EGCTS--------------------------------PFELKS-----------
--------------------------------------------------------------------------------
-------------------------APSKKMWVKLRSLLKYMVKQLE-NGEVNIVELKKNLEYTASLLEAVYIDETRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------ILDTDDELPEMRSDSVPSEVRDWLASTFTQQTRSTGRRSEEKPR--FRSIVHAVQAG
IFVERMFRRSYTAVGPNYSAAVVNSLKH------LDLWDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMS
FLDSLESGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSD---CA
ILYNDRSVLENHHVSAVYRIMQD-DEMNIFVNLTKDEF--TELRSLVIEMVLATDMSCHFQQVKTMKTSLQQLET-IDKS
KALSLLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGLPFSPLCDRKSTLVAQSQIG------FIEFIVDPTF
SVLTDVAEKTVLPLVEERSKSKSTA-----------------------------SVNQSSSQWRQPSIDDHSEMGDINAD
IKSFRTTWTKYIQENKQKWKERAASGITN------------------------QTSVDELSPCEEQHSTE-------ENG
NLD-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Fugu_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------MAELLR-----------
--------------------------------------------------------------------------------
-------------------------IRKKRLQIPI-SRLRSILKQLE-EKNVDFEEIKKNLDFTASLLEAVYLDGTRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------CLETEDDLQQLQSDGVPAEVTDWLASTFTRRVRQPARRSDEKPK--FRSIVHAVQAG
IFVERMFKRAYTAALPDQPAAVVNCLRD------VDRWSFDVFALNSASSDRALQTVFFELIARYGLNGRFKIPISCLTE
FLSAVERGYCKHNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAAAIHDYEHTGTTNNFHIHTKSE---FA
LIYNDRSVQESHHLSAAFRLLQN-EQMNIFVNLTREEW--MELRSLVIEMVLSTDMSSHLSQVKAIKACLQQQER-IDKP
KALSLLLHTADISHPSKPWPLHSRWTKALMEEFFRQGDREAELGLPFSPLCDRNSTLVAESQIG------FIDFIVYPTF
SLLTDMAEKIVIPLVEENPGPPD-------------------------------PCNRHSNLWRESSRGLQWSLAHITAE
LVSFRSTWTRHTEDNKFKWKESGCNG------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Tetraodon_PDE1B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------MAEMLR-----------
--------------------------------------------------------------------------------
-------------------------IRKKRLQIPI-SRLRSILKQLE-EKNVDYEEIKKNLDFTASLLETIYFDGTRQ--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------CLETEDDLQQLQSDGVPAEVTDWLASTFTRRVRRPVRRSDEKPK--FRSIVHAVQAG
IFVERMFKRAYTAALPDQPTAVVNCLRD------VDRWSFDVFALNSASSDRALQIVFFELIARYGLNGRFKIPISCLTE
FLSAVERGYCKYNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAAAIHDYEHTGTTNNFHIHTMSE---FA
LIYNDRSVQESHHLSAAFRLLQN-EQMNIFINLTREEW--MELRSLVVEMVLSTDMSSHLLQVKAMKACLQQQER-IDKP
KALSLLLHTADISHPSKPWPLHSRWTKALMEEFFQQGDREAELGLPFSPLCDRKSTLVAESQIG------FIDFIVYPTF
SLLTDMAEKVVIPLVEENPGPPD-------------------------------PCNRHSNLWRESSRGLQWSLAHITAE
LVSFRSTWTRHTEDNKFKWKESGSNGMS----------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Human_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------SNSLKYLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA
ILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP
KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVSPLIDETSQTGGTGQRRS--SLNS---------------ISSSDAKRSGVKTSGSEGSAPINNSVISVD
YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEQQKEMEA
KSQAE---EGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKT
DDSQE---------------------------------------------------------------------------
---------------
>Mouse_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------SNSLKHLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIDALKD------VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA
ILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP
KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVSPLIDESSQTGGTGQRRS--SLNS---------------INSSDAKRSGVKSSGSDGSAPINNSVIPVD
YKSFKATWTEVVQINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA
KSQAE---QGTTSKGEKKTSGEAKSQVNGTR--KGDNPRGKNSKGEK-AGEKQQNGDLKDGKNKADKKDHSNTGNESKKT
DDPEE---------------------------------------------------------------------------
---------------
>Rat_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MTDT---SHKKEGFKKCRSATFSIDGYSFTIVANEAGDKNARPLARFSRSKSQNCLWNSLIDGLTGNV
KEKPRPTIVQDTRPPEEILADELP--------------------------------------------------------
------------------------QLDSPEALVKTSFRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIDALKD------VDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA
ILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP
KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVSPLIDETSQTGGTGQRRS--SLNS---------------INSSDAKRSGVKSSGSEGSAPINNSVIPVD
YKSFKATWTEVVQINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA
KSQAE---QGTTSKAEKKTSGETKGQVNGTRTSKGDNPRGKNSKGDK-AGEKQQNGDLKDGKNKADKKDHSNTGNESKKA
DGTKKRSHGSPAPSTSSTSRLTLP--------------VIKPPLRHFKRPAYASS-SYAPSVPKKTDDHPVRYKMLDQRI
KIKKIQNISHHWNKK
>Cow_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------SNSLKYLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAASVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA
ILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP
KALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVSPLIDEPSQTGGTGQRRS--SLNN---------------ISSTDAKRSGVKSSGSEGSAPINNPVIPVD
YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA
KSQAE---ESASGKAEKKTSGEAKNQVNGTRTNKSNNPHGKNSKTEKSSGEKQQNGDLKDGKNKTGKKDQSDVGNDSKKT
DGKSIIPIIFFHKMCNLMQAC-----------------------------------------------------------
---------------
>Dog_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------MAKMLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA
ILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEV-IEKP
KALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVSPLIDETSQTGGIGQRRS--SLNS---------------ISSADAKRSGVKSTGSEGSAPINSSVIPVD
YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKARLAAEEKQKEMEA
KSQAE---EGAAGKTEKKTSGEAKNQVNGTRTNKSDNPRGKNSKSEKSSGEKQQNGDLKDGKNKTDRKDQSNVGSDSKKT
DDSEE---------------------------------------------------------------------------
---------------
>Horse_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------SNSLKYLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPAAVIEALKD------VDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA
ILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IEKP
KALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVSPLIDETSQTGGTAQRRS--SLNN---------------ISSADAKRSGVKSTGSEGSAPINNSVIPVD
YKSFKATWTEVVHINRERWRAKVPK------------------------------EEKAKKEAEEKDRLAAEEKQKEMEA
KSQAE---EGAAGKAERKTSGETKNQVSGTRTNKSDNPRGKNSKAEKSSGEKQQNGDLKDGKNKTEKKDQSNVGNDSKKT
DGTKKRSQGSPAPSTSSASRLTLP--------------VIKPALRHFKRPAYASS-SYAPSVPKKTDEHPARYKMLDQRI
KMKKIQNISRTWNRK
>Opossum_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---IREIEEFE----------------------------------SNSLKYLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEHAASVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIEALKD------VDKWSFDVFTLNEASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---PA
ILYNDRSVLENHHISAAYRLLQEDEEMNILSNLSKDDW--REFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA-IDKP
KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVSPLIDEPSQPGGPGHRRS--SLNS---------------ISPSDAKRSSVRSTGSEGSASINNNVLTVD
YKTFKTTWTEVVHVNRERWRAKIPK------------------------------EEKAKREAEEKAKQEAEEKKKEMEA
KSQAES--EGAPGKPEKKKSGEGKSQANGGRPNPPGKP---ASKGDKAAHAG-------DDKNKTDKKDQSNAGNDSKKA
DEPEKRPTNGGKYVETIGPK------------------------------------------------------------
---------------
>Platypus_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--MIFRFPPAALYDSS---TRAKEADS--------------------------------GGSKSQNCLWNSLIDGLTGNV
KEKAKAAIIHDPRAPEEILADDLP--------------------------------------------------------
------------------------QLDSPEALVKTSFRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPR--FKSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIEALKN------VDKWSFDVFTLNDASGDHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSD---SA
ILYNDRSVLESHHVSAAYRLLQEDEEMNILSNLSKDDW--REFRALVIEMVMATDMSCHFQQIKAMKSALQQPEE-IDKP
KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQVG------FIDFIVEPTF
TVLTDMTEKIVTPLLDEPPQTGATGYRRS--SLNN---------------LSPSEAKRCSVKSTGSEGSTSLNSSVLAVD
YKTFKATWTEVVHVNRERWKAKVPKG-----------------------------ELQGDKDKMEQSGFGSDSK------
----------------KTDAFSATGSVDASEHEDGCEWRGPTKAGNSTSIYVL---------------------------
--------------------------------------------------------------------------------
---------------
>Zebrafinch_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------NNSLKYLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLWSLLKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDDLSDIQSDSLPSEVRDWLASTFTRQMGMMLKRTEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIGVLKN------VDKWSFDVFALNDASGDHALKFIFYELLTRYDLINHFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVAQTVHYLLFKTGTVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSD---SA
ILYNDRSVLENHHVSAAYRLLQDDEEMNILSNLSKDDW--REFRALVIEMVLATDMSCHFQQIKAMKNALQQPEG-IDKS
KALSLLLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNSTMVAQSQIG------FIDFIVEPTF
TVLTDMTEKIVTPLIDEASLSGMSGFRRS--SLNS---------------ISPSEVKRSSVKSTGSEGSASLNCSILTVD
FKSFKATWTEVVQQNREKWKAQATK------------------------------EEKAKKEAEGNAYQGTDKKERDEQD
GKPDEDVTERKTEKSKEPNPGEST-RTDSSKNPGNGTWQRGMSKREAYQGGNATRTDKKMDHHHTLGEEKQHVQNGELTE
DNKLDRKEV-----------------------------------------------------------------------
---------------
>Chicken_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------SNSLKYLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIGVLKN------VDKWSFDVFALNDASGDHALKFIFYELLTRYDLINRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLFKTGVVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSD---SA
ILYNDRSVLENHHVSAAYRLLQDDEEMNILSNLSKDDW--REFRALVIEMVLATDMSCHFQQIKAMKNALQQPEG-IDKP
KALSLLLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
TVLTDMTEKIVTPLIDEASRSGMSGFRRS--SLNS---------------ISPSEVKRSSVKSTGSEGSASLNCSILTVD
FKCFKATWTEVVQQNREKWKAQATK------------------------------GEIKEDCMADKKDQ-----------
-------------------SGVGS-ESKKTDGYIHRYFKK--TDVVAWYLGHMASGDQQVTTKFTG--------HHNLTS
DIVLHLLY------------------------------------------------------------------------
---------------
>Anolelizard_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------SNSLKYLQ-----------
--------------PEQIEKIWL---------------------------------------------------------
------------------------RLRGLRKYKKTSQRLRSLVKQLE-RGEASVVDLKKNLEYAATVLESVYIDETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKRTEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPPAVIAVLKN------VDKWSFDVFALNDASGEHALKFIFYELLTRYDLISRFKIPISALVS
FVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLFKTGVVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSD---TA
ILYNDRSVLENHHLCAAFRLLQDDEEMNILSNLSKDDW--REFRTLVIEMVLATDMSCHFQQIKAMKNALQQPEG-IDKP
KALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVPQSQIG------FIDFIVEPTF
TVLTDMTEKIVTPLIEEASHSGMTGFRRS--SLNS---------------ISPSEVKRSSVKSTGSEGSASLNCSILTVD
FKCFKTTWTELVQQNREKWKAQATK------------------------------EEKTKKETEENAQQGADEKKTEERE
GK-----------KQAEESSGTKT-DKKASKSSVNGTHQTGDNKHEASQGKNITQVEKESESNPTAGQQKQ-VQNGELKN
DNKSESKNQGNELRKSEGSKQHMKTAPVPDSTNRLTLPVIKPPMHHLKKPNFASTSTTLPPFHMKTEDSLMKYKLLDQRD
RMKKIQHISHHWNRK
>Zebrafish_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------MSELSSKKQGFKKCRSATFSIDGY
SFTIGKNSWSASLATPPMRHRCFCLHS----------------------------------YRETGFFL-----------
--------------PDRADSLYRLPGAQHSPGLVHAAH------------------------------------------
------------------------DLTDCRHVAKAPLRLRCLVKQLE-RGEASVVDLKKNLEYAASVLESVYIEETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPPSVITALKH------VDTWSFDVFTLNDASGDHSLKFIFYELLTRYDLINRFKIPVSALVS
FVEALEVGYGKHRNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMLFAAAVHDYEHTGTTNNFHIQTRSD---TA
ILYNDRAVQENHHVSAAYRLLQEDDEMNILYNLSKDDW--RELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEG-IDKP
KALSLLLHTADISHPAKNWNMHYRWTTSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQIG------FIDFIVEPTF
TVLTDMIEKIMTPLIEEASPAGLAGFRRS--SLNN---------------IPSD-GKRSSVRSTGSEGGTSVNSSINAVD
FKTFKSTWNEEVHKNREKWKAQAAKDL----------------------------EEKAKQEEMEENEKKKDTDTQSSDD
NTKTEDKINTDSNAKSPDKQKEDTRPEKDSKTDQEDSGKAKVDNKEPTEQQPREKEGNKDPGGMNGAQTPSDGKEPETSS
DTDNSQRVHNGSEELNSPDSDDSESKRSYDVSQWKRRSKCAKYLLSSADSEDEHSNCGISPSSDSAAAASAPHAD-----
---------------
>Fugu_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MESP---TKEIEEFE----------------------------------STALKYLQ-----------
--------------PEQIEKIWLR--------------------------------------------------------
-------------------------LRGLRKYKKTSQRLRCLVKQLE-RGEASLNDLKKNLEYAASVLESVYIEETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPPSVISVLKN------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISSLVS
FVEALEVGYSKHKNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA
ILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKAMKNFLQQPEG-IDKP
KALSLLLHTADISHPAKNWDLHHHWTTSLLEEFFRQGDKEADLGLPFSPLCDRKSTMVAQSQIG------FIDFIVVPTF
TVLTDMMERIVTPLIDEASHSGFAGFRRS--SLNS---------------ISSEEAKRQSVKSVGSDSSSSGPGSLLTVD
IKNFKAMWNEEVYQNRERWKAQACKEA----------------------------EERAKREAEEQTQQEVEEEEPKSEA
SSSPQEANTGKMEQ------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Medaka_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------S----------------------------------KEEK---------------
--------------------------------------------------------------------------------
--------------------------------VQVRLILRCLVKQLE-RGEASLNDLKKNLEYAASVLESVYIEETRR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRNEEKPR--FRSIVHAVQAG
IFVERMYRRTSNMVGLSYPASVISVLKN------VDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISAVVS
FVEALEVGYNKHKNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSD---TA
ILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDW--RELRALVVEMVLATDMSCHFQQVKAMKNFLQQPES-IDKP
KALSLLLHTADISHPAKSWDLHHRWTTSLLEEFFRQGDKEADLGLPFSPLCDRKSTLVAQSQIG------FIDFIVVPTF
TVLSDMMERIVTPLIEEASHSGLAGF------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Honeybee_PDE1C
-------------------------------------------------------------MIDFTHHDLIQ--------
-----------IKKVNIDSQFQFHRGLGRR--------------------CREVLSCAKKRLQKSAE------VASPPDR
RATRDDIAVSSPGASPNVN--ATTS----------------------CTGT---------TSSRLHNPSSPGR-------
-----NGQLSKQGTLTIVRRSSGKN----------------------------------------KSIGGSFESSPPPHS
PDT--------LSSSQSVDL--------DEILDNVDLT------------------------------------------
-------------------TDSLPAVDTPDACDKAALRLRCLLRQLQ-HGEISAELLQRNLHYAARVLEAVFLDETKD--
-----YINATTRYRPLD--------AEIIISQKQVSQRGC------------SIDS----ISSQPMNPSPGTG-------
--------------------------------------LSSASLG-------------SALDSDGQQGHA----------
VVTQKRKLRTPVWARLLSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQLATTRRKADEKPK--FRSVAHAIRAG
IFVDRIYRRVTNTALMQFPQEVVKVLKT------LDDWSFDVFSLNEAAMGAPVKYLGYDLLNRYGMIHKFKVPATVLEC
FLGRVEEGYCRHRNPYHNNLHAADVAQTMHYILCQTGLMNWLTDLEIFATLVAAIIHDYEHTGTTNNFHVMSGSD---TA
LLYNDRAVLENHHISASFRIMRE-DECNILQNLSREEF--REFRSLVIDMVLATDMSFHFQQLKNMKNILSLAEPSVDKS
KAVSLVLHCCDISHPAKRWDLHHRWTMQLLEEFFRQGDKEKALGLPFSPLCDRNNTLVAESQIG------FIEFIVEPSM
QVCSDMLETVLTPLN-------------------------------VKESVDESNNG-----------------SGGESR
RFKIGKPWIPCLAENKRIWK-----------------------------------EQAVRGIWNKILVRCVEFDIVVLKR
NT------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Drosophilamelanogaster_PDE1C
MGDTLDETPPTRRDKPQTLNIGQEEQGSDPASGNTSSPVSSIAIPAARVPRHRLRHADRDQKRDHSSDGLVSSGELRDEF
MGIDAQPRRESLNSCEVGSPGTMSSSLGKAGRLNSSRYPSGGAGAIGLSVMGNLVGTTTRKCVLTLDGYSYVIVASTPES
LPSKRDEASGGPGSSGGTSGAATSSSSSGGGAASGAASGSVGPASGTATGTGSASGGAGGVSTPAQEAASPTVSELSGSG
SNATINGQVARHGSLTIIRRTNSRNFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLAERLSFRASGGSNGSASAGDS
RSSNQGPSNSGPAASAAVKMQPSSPNATNYLADNIQISSANLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQE
SGHSFETPSNMSFTAGQWDTESLPPVDTPDALNKAAGRIRSLLRRMD-HETVAYEDMQRNLHYAARVLEAVFIDESREGC
NGNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGVSQAPQTHSGPTGPPSNTSS
ETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPASTSTLTSQTTTSSSATAEPSAKAAESQAGSAGSSGSCSNPA
AVHRQRRLRTPTWARSMSTNKTRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPK--FRSVAHAIRAG
IFVDRMYRRVSSSALTAFPPDVVRLLKN------LDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAPGILEA
FLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFHVMSGSE---TA
LLYNDRAVLENHHASASFRLLRE-DEYNILSHLSREEF--RELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQ
KVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQIC------FIDFIVEPSM
GVMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEAKTTAAECLARKSVTGTTAS
KFNIPKPWLTCLVENKRIWK-----------------------------------EQAVKDAEARALATAAEEAAAAAAA
EAEESKPETETADGEQSEPAAEPADGAAA---------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Seaurchin_PDE1C
--------------------------------------------------------------------------------
-------------------------------------------------------------------------MEGKPNP
TEKGKSHVANPPNNA----------------------------------------------NANKESPGSPRAR------
-------VEGKKMEYRIIKKTDTKR-----------------------------------------RLRRQESQSMDEES
LAS-------------------------IDLEVS----------------------------------------------
--------------------ESMPPATSPQGAVLAALRLRSLVLRLE-REEISKKYLKENLEYAASVLDTLKQDEASR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------YHYHEEEDDLSEVTSDEVPEQVRHWLTSTFSRQSTKSRLG-DEKPR--FRSIVQALRTG
LFIDRMFRRTSATAGTVLPAKVIQIFKTIDDWSFVDDWSFDIFLLDTETDGHALKFLATEVLSRYDLQTKFKIPHSVLGA
FLDAMELGYSKYGNPYHNLLHAADVTQTVHHMLARMGLVHWLSDLEIFASLLAAIIHDFEHTGTTNAFHVNTKSD---MA
MFYNDRAVLENHHISSSFRLMRD-DERNILANLSKEEY--TELRNLVIDMVLATDMSFHFQQIKQMKSMISTTEA-LDKP
KVMALTLHCADISHPSKEWKFHYKWTTLLIREFFRQGDREREMGLPISPLCDRNSTLLAESQIG------FIDFIVDPSM
NICGDMIDRILREELNSASNSPSADSVVRNKRNSIPMAR--PCSAPRSASVPAPANNNSMNDRDRPSSPGRVSIGRRNSI
PVRCLRSWHENLHKNKSKWRDFGQQEHTGVKVLDI------------------DEDPIVQKPNKDVFHKSDTNDDSAARK
TSNANGIEEEEAPHDQATTSGSTAGAAESSGSAHAPGRQGSGER------------------------------------
--------------------------------------------------------------------------------
---------------
>Anophelesgambiae_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
----------------QTQNNRRLADEDDELSEVQPDAVPPEVREWLASTFTRQLATTRKKSDEKPK--FRSVAHAIRAG
IFVDRIYRRVSSTALMQFPPEVVRVLKT------LDDWSFDVFALAEAGNCQPVKYLGYDLLNRYGMIHKFKVPPATLET
FLTRIEEGYCRFRNPYHNNLHAADVAQTVHHVLCQTGLMHWLTDLEIFATLLAALIHDYEHTGTTNNFHVMSGSD---TA
MLYNDRAVLENHHISAAFRVLKE-DDCNVLQNLSRDEF--RELRTLIIDMVLATDMSFHFQQLKNMRNLLTLAEPQVDKS
KALSLVLHCCDISHPAKRWDIHHKWTMLLLEEFFRQGDLERELGLPFSPLCDRNNTLVAESQIG------FIEFIVEPSM
TVCADMLEIVLAPIA-------------------------------PI--------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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---------------
>Cionaintestinalis_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------E-SNSVSSEHIRQNIEYAIAVMESRYVNRIAD--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------ISDDEVPATLSGEGPVPPEIKRWLVQTFTS---HTRNRKESENKRSLRSVVHAVQAG
MFVDRMFRKTSVGPMFKTYSKVTYSIQN------IDSWSYNVFELERISEGNSLKFVFYELLNKYDLIRKFKIPLKSLFA
YCTKLQRGYRKHNNRYHNPIHAADVAQSLNCLLVNSGFVHWLSDVEMFSMIMAAIVHDLEHSGTTNTFHTNTRSP---LA
QMYNDKSVLENHHISSAFRLLNE-EDCDILANFSKDDY--QEARTLMIDMVLATDMSQHFGQLKRLQSNLQHPEN-LEKS
RAMCLMIHSADINHPSKPWNLHCRWTERLVVEFFEQGDQERGLGLPLSPLCDRHTTMVAQSQIG------FIDYVIKPTF
DVLYDI--------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Cionasavignyi_PDE1C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------EHIRRNIEYAIAVMESRYVNRVVE--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------IPDDEVPATLSGEGPVPPEIKRWLVQTFTSRRADVRGRKESETRRSLRSVVHAVQAG
MFVERMFRKTSVG-VQNLPPEVQEHFKN------IDSWSYDVFELDRISDGNSLKFVFYELLNKYDLIRKFKIPLKSLFA
YSARLQRGYRKYNNRYHNPIHAADVAQSLNCLLVSSGFVHWLSDLEMFSMIMAAVVHDLEHSGTTNTFHTNTRSP---LA
QMYNDKSVLENHHISSAFRLLNE-EDCDILVNFSKDDYPSKEARTLMIDMVLATDMSQHFGQVKKLQSNLQHPES-LEKS
RAMCLMIHSADINHPSKQWELHCRWTERLVVEFFEQGDQERKLGLPLSPLCDRHTTMVAQSQIG------FMDYVIKPTY
DVLFDIFRNVNGPVVRDAILSLRRAS------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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---------------
>Amphixous_(1)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------MSCGILHVCLH--------------RK--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------LVPDEDDLSEVEPDAVPTEVRDWLASTFTRQMQVSTRARTEKPR--FRSIVQAVRAC
NRVDRLCRK-LSGSGVNYPPGVVNLLKN------LDDWSFDVFAVNVASNSQALRYVAYEVLKTYDLLVKFKINSGVLFK
FLDALESGYGKHSNPYHNQLHAADVTQTTHYLLYSTGLVQWLADVEILAVVLSAAIHDVEHTGETNSFHVMSKDVWCIRT
MLYNDRAVLENHHISTNESWVSASQMSQMGT-----------LRTLTIDMVLATDMSFHFQQVKQIKSLLSCPES-IDKS
KALSLLLHTADIGHPAKPWHLHARWTEQLMEEFFRQGDKEKALGLPFSPLCDRNTTVIADSQIG------FIDFIVDPTF
QVMGDMLEKILTPLAP----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------
>Amphixous_(2)
--------------------------------------------------------------------------------
---------------------------------MFSSFYEFLLFLYDVAIVCIMVMCVIYINYVIVTRWIPVLIGFAWRL
VQEYLPPHISRKGDIILTQIEADYYAFIDWFEGLRYKLKEWWYREPVVEPVEEDSGEERRRSSVDLSLITAMITSQTASS
EEKQNGGQTIVKVANSGEKNAVENDTQGCSVQP-------------------------LKASSSNESVSGKRLTPRKKGS
PPRRQGPSKEDLTMSLELCTDNLP--------------------------------------------------------
------------------------PTDSLEALEKASKRIRKICTFLQSRGNVPSNLLKRNLHYIADVLEIVATDDARR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------FIDEDDELSEVEPDAVPMEVRDWLASTFTRSASVTKSGEKEKKT--FRSIVQAVRAA
N---------LS----------------------LDDWSFDVFALNEATNGQALRYVTYEIMMRYDLLAKFKIGVGTLFN
FLEALEVGYSKYQNPYHNLVHGADVTQTMHSILFQTGLVQWLTDVEIFAVVFSAAIHDFEHTGETNNFHVMSRD------
------------------------------------------FRTLVIDMVLATDMSYHFAQVKQMKSLLSCPDN-IDKA
KALSLVLHTADISHPAKNWTLHEHWTELLMEEFFRQGDKEQELGLPFSPLCDRKTTMVASSQIGKYSKGGFIDFIVQPSF
EIMSDMLDKVVAPISPRGSLANQSSATIS--------------------------------EKVEAEGSPQNGDQSEEPF
EFKVDRVWDGHLTGNKVKWKEQSTKDQAEKEAR----------------------EKAAQKAKEDAEKRDQSPLDDKAEE
KKDAENPPKITANGTVSPGNAVDLKVKPSTSPENDDQVSTKEEAVGTASPEHAEKRTTEEDKPGKIESITVKSVTKRKES
GV------------------------------------------------------------------------------
---------------
>Jelly_fish_(1)
--------------------------------------------------------------------------------
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