>Homo_sapiens_LEF1
----------------------------------------------------------------------------MPQL
SG-GGGGGGG--------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE---------
----SEIIPASNGHEVARQAQTSQEPYHDKAREHPDD---GKHPDGGLYNKGP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------SYSSYSGYIMMPN----MNNDPYMSNGSLSPPIPRT----------------------
------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV--
---NSKQ-G------------------MSRHPPAPDIPTF----------------YPLSPGGVGQITPPLGWQGQ----
------PVYPI---TGGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH
TDSDLMHVK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESASG---------------------------------
----------------------------------------------TGPRMTAAYI------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Macaca_mulatta_LEF1
----------------------------------------------------------------------------MPQL
SG-GGGGGGG--------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE---------
----SEIIPASNGHEVARQAQTSQEPYHDKAREHPDD---GKHPDGGLYNKGP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------SYSSYSGYIMMPN----MNNDPYMSNGSLSPPIPRT----------------------
------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV--
---NSKQ-G------------------MSRHPPAPDIPTF----------------YPLSPGGVGQITPPLGWQGQ----
------PVYPI---TGGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH
TDSDLMHVK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG---------------------------------
----------------------------------------------TGPRMTAAYI------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Mus_musculus_LEF1
----------------------------------------------------------------------------MPQL
SGGGGGG-----------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE---------
----SEIIPASNGHEVVRQAPSSQEPYHDKAREHPDE---GKHPDGGLYNKGP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------SYSSYSGYIMMPN----MNSDPYMSNGSLSPPIPRT----------------------
------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV--
---NSKQ-G------------------MSRHPPAPEIPTF----------------YPLSPGGVGQITPPIGWQGQ----
------PVYPI---TGGFRQPYPSSLSGDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH
TDSDLMHVK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG---------------------------------
----------------------------------------------TGPRMTAAYI------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Loxodonta_africana_LEF1
----------------------------------------------------------------------------MPQL
SG-GGGGGGG--------------DPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE---------
----SEIIPASNGHEVARQAQTSQESYHDKAREHPDE---GKHPDGGLYNKGP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------SYSGYSGYIMMPN----MNNDPYMSNGSLSPPIPRT----------------------
------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGSHPSHIPSDV--
---NSKQ-G------------------MPRHPPAPDIPTF----------------YPLSPGGVGQITPPLGWQGQ----
------PVYPI---TGGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH
TDSDLMHVK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG---------------------------------
----------------------------------------------TGPRMTAAYI------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Anolis_carolinensis_LEF1
----------------------------------------------------------------------------MPQL
SGGGGGGGGGGG----------GGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNE---------
----SETISSSNGHEVSRQGQ-PQEIYHDKGREHPEE---GKHTDGGLYGKGP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------SYSGYSGYIMMPN----MNNDPYMSNGSLSPPIPRT----------------------
------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFSPGTHPSHLPSDV--
---NSKQ-G------------------MSRHPPGPDMPTF----------------YPLSPGSVGQITPPLGWQGQ----
------PVYPI---SSGFRQPYPSSLSVDTSMS----------RFSHHMIPG-PPGPHTTGIPHP--AIVTPQVKQEHPH
TDSDLMHVK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG---------------------------------
----------------------------------------------AAPRMTAAYI------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Xenopus_tropicalis_LEF1
----------------------------------------------------------------------------MPQL
SGAGGGNGGGG-------------DPELCATDEMIPFKDEGDPQKEKIYAEISNPEEEGDLADIKSSLVNE---------
----TEIIPSSNSHEISRRRQ---DSYHEKSREHPED---GKHPDGGLYSKGP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------SYTGYPSYIMMPN----MNNEPYMSNGSLSPPIPRT----------------------
------------------------------------SNKVPVVQPSHAI-HPLTPLITYSD-EHFAPGAHPSHIPSDV--
---NSKQ-G------------------MHRHPQAPDLPTF----------------YPLSPGSVGQMTPPLGW-------
--------------------------------------------YPHHMVSG-PPGPHATGIPHP--AIVNPQVKQEHPH
NDNDLMHMK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PHHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKLQESTSG---------------------------------
----------------------------------------------VCAELHLLWV------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Takifugu_rubripes_LEF1a
----------------------------------------------------------------------------MEGG
GGGGEGRGGGEGGGGGGGQGCGGGDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE---------
----SESSPNSNSHDGVRQSQIP-DSYHEKHRDHQEDEERGKLQD--LYCKGH---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------PYSGYPSYSMMSN----MDAS-YMNNGSLSPPMPRTEVYIQTLWALLDMPSHGNGRD-
---------------------------TQRPPPDSISNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGSHSGHHPHDG--
---SNKQ-G------------------MPRQHPGPDMANF----------------YSLSPGGVGQITPPLGWLLQRRGR
---HPYDIQLY---HLLPFLPPICLCS-SCVSG----------LFSHHMVPG-PPGPHATGIPHP--AIVNPQIKHEPLH
-ETDIMHMK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKDQEPKKP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREK----------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Tetraodon_nigroviridis_LEF1a
----------------------------------------------------------------------------MPQL
SGGG-------------------GDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE---------
----SESSPNSNSH-GVRQSQIP-DSYHEKHRDHQEDV--GKLQD--LYSKGH---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------PYSGYPSYSMMSN----MNDSSYMNNGSLSPPMPRTHLYTTHTHICVYNTHAHQIKSN
YLQSGKWSTVKNQGGSLMSKQEQLSFRSPPHPHIPESNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGSHSGHHPHDG--
---SSKQ-G------------------MPRQHPGPDMPNF----------------YSLSPGGVGQITPPLGWFC-----
---FVFFPFFL---PNYRNFSPLFQLM-LTDIS----------TFSHHMVPG-PPGPHATGIPHP--AIVNPQIKHEPLH
-ETDIMHMK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKDQEPKKP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREK----------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Gasterosteus_aculeatus_LEF1b
----------------------------------------------------------------------------MPQL
SGGG-------------------GDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE---------
----SESSPNSNSHDGARLSQIPQDSYHEKHRDHLED---GKLQD--LYSKGH---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------PYQGYPGYIMMSN----MNDS-YMNNGSLSPPMPRT----------------------
------------------------------------SNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGPHP-QDVNNK--
---QACL-G------------------MQRHHQGPDMTNF----------------YSLSPGGVGQLTPPLGWF------
---------------------------------------------SHHMVPG-PQGPHATGIPHP--AIVNPQVKHEPLH
-ETDIMHMK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKEQEPKRP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRRKQWHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKMQESAPG---------------------------------
----------------------------------------------TGQRMKTAYIS-----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Oryzias_latipes_LEF1b
----------------------------------------------------------------------------MPQL
SGGG------------------GGDPELCATDEMIPFKDEGDPHKEQIFAELSHSEEEGDLADIKSSLVNE---------
----SESSPNSNNHDAARQSQIPPDSYHEKHRDLIEDE-RGKHAD--MYGKGH---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------VYPSYPGYIMMN-----MNSDSYMNNGSLSPPMPRTYNFFKWDYITVQTESVVTTQT-
-----------------------LCDLHSESNSHLASNKVPVVQPSHAV-HPLTPLITYSD-EHFAPGSHSGLHPQDA--
---NNKQ-G------------------MPRHHPGPDMPNF----------------YSLSPGGVGQITPPLGWLNTREGP
---KCDPTGCH---RKSLFSTSLQSLKNPLHSR----------MFSHHMVPG-PPGPHATGIPHP--AIVNPQIKHEPPH
-ETDIMHIRK----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------PQHEQRKEQEPKKP---HIKKPLNAFMLYMKEMRANVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREK----------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Branchiostoma_floridae_LEF1
----------------------------------------------------------------------------MPQL
NGSGGDDLGAG--------------------DETISFKDEGEQEEKSAENVSN------DLSDIKSSLANE---------
------SESSQSGAVPSEGSKPPLQSYPREDSRRGDEG--SKAESVPVVSRGP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------AYLTPGGVIVSNMG------VYPHPNGSLAASATSN----------------------
--------------------------------------KVSVVHGPPHP-GPLTQLMMYSN-EHFAPG-TPPHIGVPPNS
IEVDPKTG-------------------IPRPRHPADLPPM----------------YAIPPNQLPQLGPSYPKIEEYHSQ
ALWQSQGVYPIS--AAGYRHPYPTAIAVNATNMP----------RYPVLQHPHHPGMPPTGIPHP--AIVSP--HGMNLK
HDPSQMHQK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------QDQKKEPEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALPREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQQGDTSEVSN------------------------------
------------------------------------PKRCRARFGLDQQQAWCKPCR-------YGADEWR---------
---------ESPILFCFC-LPVWN-------------------------------GGFKAQALP--NGSVV---------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Homo_sapiens_TCF7
-----------------------------------------------------------------------MPQLDSGGG
GAGGGDDLGAP--------------------DELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESEGAAGGAGIP
GVPGAGAGAR-GEAEALGREHAAQRLFPDKLPEPLEDGLKAPECTS-GMYKETV--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ-----------------------
----------------------------------------PPLH-KANQPPHGVPQLS-LY-EHFNSP-HPTPAPADI--
---SQKQ--------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSW-------
-------------------------------------------FTHPSLMLGSGVPGHPAAIPHP--AIVPPSGKQELQP
FDRNLKTQA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------ESKAEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT----------------------------------
-------------------------------------DPGSPKKCRARFGLNQQT-DWCGPCRRKKKCIRYLPGEGRCPS
PVPSDDSALGCPGSPAPQDSPSYHLLPRFPTELLTSPAEPAPTSPGLSTALSLPTPGPPQAPRSTLQSTQVQQQESQRQV
A-------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Macaca_mulatta_TCF7
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------H-KANQPPHGVPQLS-LY-DHFNSP-HPTPAPADV--
---SQKQ--------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSW-------
-------------------------------------------FTHPSLMLGSSVPGHPAAIPHP--AIVPPSGKQELQS
FDRNLKTQA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------ESKAEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT----------------------------------
-------------------------------------DPGSPKKCRARFGLNQQT-DWCGPCR-----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Mus_musculus_TCF7
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------MYKETV--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YSAFNLLMPYPP-----------ASGAGQHPQPQ-----------------------
----------------------------------------PPLHNKPGQPPHGVPQLSPLY-EHFSSP-HPTPAPADI--
---SQKQG-------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSWPSPPLY-
--------PLSP--SCGYRQHFPAPTAAPGA--------PYPRFTHPSLMLGSGVPGHPAAIPHP--AIVPSSGKQELQP
YDRNLKTQA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------EPKAEKEAKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT----------------------------------
------------------------------------------GGKRNAFGTYPEK-AAA-PAP-------FLP-------
-----MTVL-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Canis_familiaris_TCF7
-----------------------------------------------------------------------MPQLDAGGG
GA-GGGDLDAP--------------------EELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSRVNESEGAAGGAGVP
GAGAGARGAAEVGAEALGREHASQRLFPDKLPESLEDGLKAPECAS-GMYKDTV--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ-----------------------
----------------------------------------PPLHNKASQPAHSVPQLSPLY-EHFSSP-HPTSAPADI--
---SQKQG-------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSWPSPPLY-
--------PLSP--SCGYRQHFPAPTAAPGA--------PYPRFTHPSLMLGSGVPGHPAAIPHP--AIVPPSGKQELQP
YDRSLKTQA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------ESKVEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESTT----------------------------------
------------------------------------------GGKRNAFGTYPEK-AAA-PAP-------FLP-------
-----MTVL-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Bos_taurus_TCF7
------------------------------------------------------------------------PQLDSGGG
GAGGGDDLGAP--------------------DELLAFQDEGEEQDDKSRDSAAGPERDLAELKSSLVNESEGAAGDAGVP
GAGAGARGEAEVGAEALGREHTSQRLFPDKLPESLEDGLKAPECTS-GMYKDTV--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ-----------------------
----------------------------------------PPLHNKASQPSHGVPQLSPLY-DHFSSP-HPTPAPADI--
---SQKQG-------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSWPSPPLY-
--------PLSP--SCGYRQHFPAPTAAPGA--------PYPRFTHPPLMLGSGVPGHPAAIPHP--AIVPSSGKQELQP
YDRSLKAQA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------DSKAEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESNS----------------------------------
------------------------------------------GGKRNAFGTYPEK-AAA-PAP-------FLP-------
-----MTVL-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Loxodonta_africana_TCF7
-----------------------------------------------------------------------MPQLDSGGG
SAGGGDDLGAP--------------------DELLAFQDEGEEQD-KSRDSAAGPERDLAELKSSLVNESEGAAGGAGVP
---GTGAEAE-ARAEALGREHTSQRLFSDKLPESLEDGLKAPECVS-GMYKETV--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YSAFNLLMHYPP-----------PSGAGQHPQPQ-----------------------
----------------------------------------PPLHNKASQPPHGVPQLSPLY-EHFSSP-HPTPAPADI--
---NQKQ--------------------VHRPLQTPDLSGF----------------YSLTSGSMGQLPHTVSW-------
-------------------------------------------FTHPSLMLGSGVPGHPAAIPHP--AIVPPSGKQELQP
YDRSLKTQA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------EAKVEKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRSREKHQESNT----------------------------------
-------------------------------------DPGSPKKCRARFGLNQQT-DWCGPCRRKKKCIRYLPGEGRCPS
PVPSDDSALGCPGSPAPQDSPSYLLLPHLPTELLASPAEPAPTSPGLCATLSLPATGPQQAPRRTLQSTQVQPQESQR--
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Gallus_gallus_TCF7
----------------------------------------------------------------------------MPQL
GSGGGDDLGAT--------------------DEMLAFKDEG--EQEEKIPENAFTERDLADLKSSLVNES----------
EGSGSPAAAADP-EAIRRVQD-PQRVYQEKLPDHMDDAG--MKHQDPGMYKGSA--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YSGYPFLMLSDPY---------LPNGSMSPL--------------------------
-------------------------------------SNKVPVVQPSHGVHPLTPLIPYSN-DHFSHGSHSPHLPADI--
---SQKQA-------------------VHRPSQTSDIPGF----------------YPLPPAGVGQITPSMG--------
------------------------------------------WFTHPLML-GSGMH--TTGIPHP--AIVPHSGKQEMEH
YDRN--MKP-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------QPEPKREKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRTREKQQDS------------------------------------
-----------------------------------NSDPASPKKCRARFGLNQQT-DWCGPCSFLQQFQLLSKYLFEFLK
PL------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Anolis_carolinensis_TCF7
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------MSPL----------------SNKVPVGQ-----------------------
-----------------------------------------PSH--GVHPLT--PLIPYSN-EHFSHGSHSPHLPADI--
---SQKQG-------------------VHRPSQTSDIPGF----------------YSLPPTGVGQITSSMGW-------
-------------------------------------------ITHP-LMLGSGM--HTTGISHP--GITSP-GKQEMDH
YDRSMKSQP-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------EPKREKEAKKP---TIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKRRTREKQQDSNSG---------------------------------
-------------------------------------G------KRSAFGTYKED-AVP---------AQF---------
---LPMEVL-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Danio_rerio_TCF7a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------V---PKHHDGGMYKAP---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YSGYPFLMLPEPY---------LPNGPVSPS--------------------------
-------------------------------------SNKVSVVQQ--GMHPLTPLLPY---EHFNP--SPTHMPTDG--
---GQKPG-------------------VHR-HQTQEISGF----------------YSLPQG---QITPSMN--------
------------------------------------------WFSHSLML-QSGMH--PTGIPHP--AIVPPSGKQEHDQ
FDRSIYNKS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------HAEAKREKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA
KYYELARKERQLHMQLYPSWSARDNYVSALGKKKRRKRDKQQDS------------------------------------
-----------------------------------STEPGSPKKCRARFGLNQQT-DWCGPCR-----------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Takifugu_rubripes_TCF7a
----------------------------------------------------------------------------MPQL
SSGGGDDLGAN--------------------DEMIAFKDEG--EQEEKIQENALTERDLADLKSSLVNES----------
ETNQSPNAASTPPQAIRRAQQGEQRGFAEKHREHLDGV---SKHQDGGIYKTPT--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YPGYPFLMLPDPY---------LPNGSVSPS--------------------------
-------------------------------------SNKVSVVQQSHGMHPLSSLLPYGN-EHFSP--SPPHLPADM--
---SQKPG-------------------VHR-HQSQDLSGY----------------YSLPPGGVGQITPSMS--------
------------------------------------------WFPHPLMLGPSGMH--PTGIPHP--AIVPPTGKQDHDQ
YDRGMYLK------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------QEVKQQKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA
KYYELARKERQLHMQLYPTWSARDNY----GKRKKRKREKLQDS------------------------------------
-----------------------------------GADPGSPKKCRARFGLNQQT-DWCGPCSSFATQKGQRNHFLSLFL
SPL-----------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Tetraodon_nigroviridis_TCF7b
----------------------------------------------------------------------------MPQL
SSGGGDDLGAN--------------------DEMIAFKDEG--EQEEKIQENALTERDLADLKSSLVNES----------
ETNQSPNAA-----AIRRAQQGEQRSFAEKHRELIDGV---SKHQDGGMYKTPA--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YTGYPFLMLPDPY---------LPNGSVSPSSRFPLICIWPLRMTAQAGHSRKRPVR
IDVTGFSPVFVLQQ-----------------------SNKVSVVQQSHGMHPLSSLLPYGN-EHFSP--SPPHLPADM--
---SQKPG-------------------VHR-HQSQDLSGY----------------YSLPPGGVGQISPSVSWLLVRQG-
--------QAVY--PTLSPCGFRQPYASNLS----STPSSYSRFPHPLMLGPSGMH--PTGIPHP--AIVPPTGKQEHDQ
YDRGMYLK------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------QEVKQQKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA
KYYELARKERQLHMQLYPTWSARDNY----GKKKEEKTGE----------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Oryzias_latipes_TCF7b
----------------------------------------------------------------------------MPQL
SSGGGDDLGAN--------------------DEMISFKDEG--EQEEKIQENAFTERDLADLKSSLVNES----------
EISQSPSAA-----AARRGHQGEQRGFPDKHREHLEGV---SKQQDGSMYKSAA--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YPGYPFLMLPDPY---------LPNSSVSPSQRTYIKKKRWRIISKQQKMLQRRTGV
LHLENPTSAHIVD------------------------SNKVSVVQQSHGMHPLTSLLPYSN-DHFSP--SPPHLPTDM--
---SQKTG-------------------VHR-HQSQDLSGY----------------YSLPPGGVGQIPPSMSCFLPKQS-
--------QPVY--PGLSPCGFRQSYSSNLPRNFLSSFLPGTRFPHSLMLGPSGMH--PTGIPHP--AIVPPSGKQEHDQ
YDRGILLSPI----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------RKQQVETKREKEPKKP---VIKKPLNAFMLYMKEMRAKVIAECTLK--ESAAINQILGRR--WHALTREEQA
KYYELARKERQLHMQLYPTWSARDNY----GKKKRRKREKQQDSNTAHICTVQ---------------------------
---------------------YPGVSLGITPGRSLRSDPGSPKKCRARFGLNQQT-DWCGPC---------RLKFLDVCP
PSSEK---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Homo_sapiens_TCF7L2
----------------------------------------------------------------------------MPQL
NGGGGDDLGAN--------------------DELISFKDEGEQEEKSSENSSA----ERDLADVKS--------------
-SLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGP--PYPGYPFIMIPDLT---SPYLPNGS
LSPTARTLHFQSGS------------------------------------------------------------------
--------------------------------------------------------------------------------
-------THYSAYKTIEHQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHTLHTTGIPHP--AIVTPTVKQESSQ
SDVGSLHSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETN-EHS----ECFLNPCLSLP-----PITDLSAPK
KCRARFGLDQQNNWCGPCRRKKKCVRYIQG-EGSCLSPPSSDGSLLDSPPPSPNLL--GSPPRDAKSQTEQTQPLSLSLK
P----DPLAHLSMMPPPPA--LL------LAEATHKASAL--------CPNGALDLP-PAALQP--AAPSSSIAQPSTSS
LH-----SHSSLAGT-QPQPLSLVTKSLE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Macaca_mulatta_TCF7L2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------LHFQSGST---HYSAYKTI
EHQIAV--------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------QYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHTLHTTGIPHP--AIVTPTVKQESSQ
SDVGSLHSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNEHS-----ECFLNPCLSLP-----PITDANTPK
KCRALFGLDRQTLWCKPCRRKKKCVRYIQG-EGSCLSPPSSDGSLLDSPPPSPNLL--GSPPRDAKSQTEQTQPLSLSLK
P----DPLAHLSMMPPPP--ALL------LAEATH-KAS-AL------CPNGALDLP-PTALQP-AAPS-SSVAQPSTSS
LH-----SHSSLAGT-QPQPLSLVTKSLE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Mus_musculus_TCF7L2
----------------------------------------------------------------------------MPQL
NGGGGDDLGAN--------------------DELISFKDEGEQEEKNSENSSA----ERDLADVKS--------------
-SLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGP--PYPGYPFIMIPDLT---SPYLPNGS
LSPTAR--------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------TYLQMKWPLLDVQAGSLQSRQTLKDARSPSPAHIVS----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHTLHTTGIPHP--AIVTPTVKQESSQ
SDVGSLHSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNDLSAPK--KCRARFGLDQQNNWCGPCRDANTPK
KCRALFGLDRQTLWCKPCRRKKKCVRYIQG-EGSCLSPPSSDGSLLDSPPPSPHLL--GSPPQDAKSQTEQTQPLSLSLK
P----DPLAHLSMMPPPP--ALL------LAEAAHGKAS-AL------CPNGALDLP-PAALQPSMVPS-SSLAQPSTSS
LH-----SHNSLAGT-QPQPLSLVTKSLE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Gallus_gallus_TCF7L2
----------------------------------------------------------------------------MPQL
NGGGGDDLGAN--------------------DELISFKDEGEQEEKISENSSA----ERDLADVKS--------------
-SLVNESETNQNSSSDSEAERRPPPRSETFRDKSRESLEEAAKRQDGGLFKGP--PYPGYPFIMIPDLS---SPYLPNGS
LSPTAR--------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------TYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPTVKQESSQ
SDVGSLHSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNEHS-----ECFLNPCLSLP-----PITDLSAPK
KCRARFGLDQQNNWCGPCRRKKKCVRYIQG-EGSCVSPPSSDGSLLDSPPSSPAML--ASPSRDSKPQTEQTQPLSLSLK
P----DPLAHLVMMPPPS--SLV------LAESAASKPG-ALPAAS--CPNGALDHA-PAALPP-----AASLAQPSTSS
LH-----SHSSLAGP-QPQPLSLVTKSLE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Anolis_carolinensis_TCF7L2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MKWPLLDVQAGSLQSRQALKDARSPSPAHIVS----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLPADV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPTVKQESSQ
NDVGSLHSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKRDKQP-GETNGKTQ----RMFLNPCLSLP-----PITDLSAPK
KCRARFGLDQQNNWCGPCRRKKKCVRYIQG-EGSCVSPPSSDGSLLDSPPSSPNML--ASPTRDSKSQTEQTQPLSLTLK
P----DPLAHLPLMPPASSSSVV------LTESSTSKPR-GLPASN--CQNGALDHQ-SATLQQ-SAPSSSSLVQPSTSS
LH-----SHNSLAGT-QPQPLSLVTKSLE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Xenopus_tropicalis_TCF7L2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------S----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQADV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPTVKQESSQ
SDMGSLHSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KHQDSKKEEEKKKP---HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKQQ-GEANEHS-----ECYLNPCLSLP-----PITDLSAPK
KCRARFGLDQQNNWCGPCRRKKKCIRYIQG-EGSCVSPPSSDGSLLDSPPSSPAMP--DSPASDSKPQTEQTQPLSLSLK
P----DPLARI-CVPHSP-----------LAQSPARKPS-ALP--VTICQNGAEHAH-PHNVLQSSLPYGLSLTQPSTSF
LP-----SHRSLAGTTQLQPLSLVTKPLE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Danio_rerio_TCF7L2a
----------------------------------------------------------------------------MPQL
NGGGGDDLGAN--------------------DEMISFKDEGEQEEKISENSSA----ERDLADVKS--------------
-SLVNESETNQNSSSDSEAERRPPPRSESFRDKTRESLEEAAKRQDGGLFKSP--PYPGYPFIMIPDLT---SPYLPNGS
LSPTAR--------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------TYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVS----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQADV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMSS-----LLSSRFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESSH
SDIGSLNSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KHQDAKKEEEKKKQP--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKKKKRKREKQA-GEGNEHR-----EYFPNPCLSLPP-----ITDLSAPK
KCRARFGLDQQNNWCGPCRRKKKCIRYIQG-EGSCASPPSSDGSLLESPPSSPSMISPSPSSKESKPQTEQMQPLSLTMK
PPPLLSSSQHQHLSMAPPPPLAL------LDNSGAG-KTSG------SAHNGSLDPSDVSSSRSTGS----ASSRP-ISA
CH-----SHSLLPSSAPTQPLSLVTKSID---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Takifugu_rubripes_TCF7L2a
----------------------------------------------------------------------------MPQL
NGGGGDDLGAN--------------------DEMISFKDEGEQEEKISENSSA----ERDLADVKS--------------
-SLVNESETNQNSSSDSEAERRPPPRSETFRDKTRESLEEAAKRQDGGLFKSP--PYPGYPFIMIPDLT---SPYLPNGS
LSPTAR--------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------TYLQMKWPLLDVQPGGLQSRQALKDARSPSPAHIVS----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQTDV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMSS-----LLSSRFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESTH
SDINSLNSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KQSDSKKEPEKKKEV--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKRKKRKREKQQQAEGNEHR-----EYFPNPCLSLPPI--TAASDLSAPK
KCRARFGLDQQNNWCGPCRRKKKCIRYIQG-EGSCASPPSTDGSLLDSPPSSPSSVVPSPSPKESKPQTEQMQPLSLTMK
P--AHQPLHHPHLLAGPTPPLVQ------LENSAAASKTPGA-----SSHNGALEHVNVSSSRQRGSSVVPSMARPSASL
CH-----SQSLLP----AQPLSLVTKSIE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Tetraodon_nigroviridis_TCF7L2a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------ILQSP------FTQILT-YFV---SPFS----
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------FLQ-------------------------------S----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQTDV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMSS-----LLSSRFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESTH
SDINSLNSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KQSDSKKEPEKKKEV--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKRKKRKREKQQQAEGN---------------------------------
-----------------GKRKKKCIRYIQG-EGSCASPPSTDGSLLDSPPSSPSSVVPSPSPKESKPQTEQMQPLSLTMK
P--AHQPLHHPHLLAGPTPSLVQ------LENTAAASKTPGT-----SSHNGALEHGDVSSSRQRGSSVVPSMARPSASL
CH-----SQSLLPT--APQPLSLVTKSIE---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Oryzias_latipes_TCF7L2a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------Q---------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------S----------------------
-------------------------------------NKVPVVQHPHHV-HPLTPLITYSN-EHFTPGNPPPHLQTDV--
---DPKTG-------------------IPRPPHPPDISPY----------------YPLSPGTVGQIPHPLGWLVPQQG-
-----QPVYPIT--TGGFRHPYPTALTVNASMS----------RFPPHMVPP-HHSLHTTGIPHP--AIVTPNVKQESSH
SDISSLNSS-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KQSDAKKEEEKKKQV--HIKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRR--WHALSREEQA
KYYELARKERQLHMQLYPGWSARDNY----GKRKKRKREKQQ-AESN---------------------------------
-----------------------------------ASDLS--------------------APKKCR--------------
---ARFGLDQQNNWCGPCRC------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Strongylocentrotus_purpuratus_TCF7L2
----------------------------------------------------------------------------MPQQ
HSRGGEDDGPP--------------------DETKTYHTEGEQEEKASENVVGPRDSFDHLNDVKSSLIDEGE-------
----SVSQKGSSSQRNKRLSSGYGDHSKEDRHKKLHSVSDGSKLDHIARFTPYS--------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------SLAFIANAGYPNGSMVGGPGITPKCGVPNVFPSPLRLGE----------------------
------------------------------------GQKMPVLHPGAYPPSLAQLMMYQQEHYSHSPGTPPPHVRGLEV-
---DSKTG--------------------ILRRSHSEISPY----------------HPLSPSSLGTHPLEVYNMSWPGQ-
------PFYPLT--SSALRSPYPSSLAVSPASMAR-------LGPSPIGAGPIPVGSLPHFLMHP---IGSSQQHDAQQQ
SNDRHQKEK-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------EKKLAAQEAKNKQQ---HIKKPLNAFMLYMKEMRASVVKECTLK--ESAAINQILGRR--WHALTREEQA
KYYELARKERQLHMQLYPGWSARDNYAIH-GKKKKKKRDKSHGDNPG---------------------------------
-------------------------------------EPSTPKKCRARFGVDQQDFWCKPCRRKKKCIRYISSDENDHGR
NDDDMDDDDSSLSRRKSWLKHGGTQH------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Homo_sapiens_TCF7L1
-------------------------------------------------------MPQLGGGGGGGGGG-SGGGGGSSAG
AAGGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ-----
-SSSSDSEA---ERR--PQPVR--DTFQKPRDYFAEV----RRPQDSAFFKGP--PYPGYPFLMIPDLS---SPYLSNGP
LSPGGART------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLSN----------------------
--------------------------------------KVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI--
---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP
PSLSPAVSV-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA
KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQVQEAEG----------------
--------------ALASKSKKPCVQYLPP-EKPCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK
P----ETRAQLAL-HSAAFLSAK--------AAASSSGQMG-------SQPPLLSRPLPLGSMP--TALLASPP-SFPAT
L------HAHQALPVLQAQPLSLVTKSAH---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Macaca_mulatta_TCF7L1
-------------------------------------------------------MPQLGGGGGGGGGGCSGGGSGSSAG
AAGGGDDLGAN--------------------DELIPFQDEGSEEQEPSSDSASA---QRDLDEVKSSLVNESENQ-----
-SSSSDSEA---ERR--PQPAR--DTFQKPRDYFADV----RRPQDSAFFKGP--PYPGYPFLMIPDLS---SPYLSNGP
LSPGGART------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLSN----------------------
--------------------------------------KVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI--
---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPVYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP
PSLSPAVSA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA
KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQVQEAEG----------------
--------------ALASKSKKPCVQYLPP-EKPCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK
P----ETRAQLAL-HSAAFLSAK--------AAASSSGQMG-------SQPPLLSRPLPLGSMP--TALLASPP-SFPAT
L------HAHQALPVLQAQPLSLVTKSAH---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Mus_musculus_TCF7L1
-------------------------------------------------------MPQLGGGRGGGAG---GGGGGSGAG
ATSGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ-----
-SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--AYPGYPFLMIPDLS---SPYLSNGP
LSPGGART------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLYGDPARW-----------------
-----------------------------MVPPTFRSNKVPVVQHPHHM-HPLTPLITYSN-DHFSPASPPTHLSPEI--
---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRF-PHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAA
PSLSPAVSA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA
KYYELARKERQLHAQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQIQEAEG----------------
--------------ALASKSKKPCIQYLPP-EKPCDSPASSHGSTLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK
P----EARAQLAL-HSAAFLSAK--------AAASNSSQMG-------SQPPLLSRPLPLGSMP--AALLTSPP-TFPAT
L------HAHQALPVLQAQPLSLVTKSAH---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Rattus_norvegicus_TCF7L1
-------------------------------------------------------MPQLGGGRGGGAG---GGGGGSGAG
ATSGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ-----
-SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--AYPGYPFLMIPDLS---SPYLSNGP
LSPGGART------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YLQMKWPLLDVP-----SSATVKDTRSPSPAHLS-----------------------
-------------------------------------NKVPVLQHPHHLQHPLTPLITYSN-DHFSPASPPTHLSPEI--
---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP
PSLSPAVSA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA
KYYELARKERQLHAQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQIQEAEG----------------
--------------ALVSKSKKPCIQYLPP-EKPCDSPASSHGSTLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK
P----ETRAQLAL-HSAAFLSAK--------ATASNSSQMG-------SQPPLLSRPLPLGSMP--TALLTSPP-SFPAT
L------HAHQTLPVLQAQPLSLVTKSAH---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Canis_familiaris_TCF7L1
------------------------------------------------------------GGGGGGGGGGGGGGGGSGAG
AAGGGDDLGAN--------------------DELIPFQDEGGEEQEPSSDSASA---QRDLDEVKSSLVNESENQ-----
-SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--PYPGYPFLMIPDLS---SPYLSNGP
LSPGGART------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YLQMKWPLLDVP-----SSTTVKDTRSPSPAHLSN----------------------
--------------------------------------KVPVVQPPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI--
---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPAP
PSLSPAVSA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA
KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS--------QQQVQEAEG----------------
--------------ALASKSKKPCVQYLPP-EKSCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK
P----ESRAQLAL-HSAAFLSAK--------ATATSSGQMG-------SQPPLLSRPLPLGSLP--TALLTSPP-SFPAT
L------HAHQALPVLQAQPLSLVTKSAH---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Bos_taurus_TCF7L1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YLQMKWPLLDVP-----ASATVKDARSPSPAHLSN----------------------
--------------------------------------KVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI--
---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLSWLVPQQG-
-----QPMYSLP--PGGFRHPYP-ALAMNASMSS-----LVSSRFSPHMVAPTHPGLPTSGIPHP--AIVSPIVKQEPAP
PSLSPAVSA-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------KSPVTVKKEEEKKP---HVKKPLNAFMLYMKEMRAKVVAECTLK--ESAAINQILGRK--WHNLSREEQA
KYYELARKERQLHSQLYPTWSARDNY----GKKKKRKREKQLSQTQS-------QQQQVQETDG----------------
--------------ALASKSKKPCVQYLPP-EKPCDSPASSHGSMLDSPATPSAAL--ASPAAPAATHSEQAQPLSLTTK
P----ETRAQLAL-HSAAFLSSK--------AAATSSGQMG-------SQPPLLSRPLPLGSVP--TALLTSPP-SFPAT
L------HTHQALPVLQAQPLSLVTKSAH---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------
>Loxodonta_africana_TCF7L1
-------------------------------------------------------MPQLGGGGAGGGG----GGGGSGAG
AAGGGDDLGAN--------------------DELIPFQDEGSEEQEPSSDSASA---QRDLDEVKSSLVNESENQ-----
-SSSSDSEA---ERR--PQPAR--DAFQKPRDYFAEV----RRPQDGAFFKGP--PYPGYPFLMIPDLS---SPYLPNGP
LSPGGART------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------YLQMKWPLLDVP-----SSSTVKDTRSPSPAHLVSLPSPWQ----------------
-----------------------------LFLSVFQSNKVPVVQHPHHM-HPLTPLITYSN-DHFSPGSPPTHLSPEI--
---DPKTG-------------------IPRPPHPSELSPY----------------YPLSPGAVGQIPHPLGWLVPQQG-
-----QPMYSLP--PGSFRHSYP-ALAMNASMSS-----LVSSRFSPHMVAPAHPGLPTSGIPHP--AIVSPIVKQEPTP
PSLSPAVSV--------------------------------------------------------------------