>Homo_sapiens_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD
KYWNRFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTQDYQTA
-----------------------------LCVSRKHLLP--------------------------RQKKGNVAQKHWVGP
SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHSYTS------------------
-KCKLEFHACSTGKS-----------------------------LATLCDGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PEPEP--PKHKAER
SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSNTAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NELAGSRKQGAVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEYE---RELGPKDKEGKLRVHTRAVTEDDEDEDD
DKEDEVGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gorilla_gorilla_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD
KYWNRFRDVSTG---------------------------ATR-PRGAGGL--LSLLCKTEALKVKCSPHKVCVTQDYQTA
-----------------------------LCVSRKHLLP--------------------------RQKKGNVAHKHWVGP
SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHSYTS------------------
-KCKLEFHACSTGKS-----------------------------LTTLCDGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PEPEP--PKHKAER
SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSNTAQA-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----KY-----------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Macaca_mulatta_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MPAIAVLAAAAAAWCFLQVESRHLDALAGGAGPNHGNFLDNDQWLSTVSQYDRD
KYWNRFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTQDYQTA
-----------------------------LCVSRKHLLP--------------------------RQKKGNVAHKHWVGP
SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHSYTS------------------
-KCKLEFHACSTGKS-----------------------------LTTLCDGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PEPEP--PKHKAER
SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSNTAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NELAGSRKQGAVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKEGKLRVHTRAVTEDDEDEDD
DKEDEVGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MPAIAVLAAAAAAWCFLQVDSRHLDALAGGAALNNANFLDNDQWLSTVSQYDRD
KYWNRFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTQDYQTA
-----------------------------LCVSRKHLLP--------------------------RQKKGNVAHKHWLGP
SNLVKCKPCP--------------------------------VAQS---AMVCGSDGHTYTS------------------
-KCKLEFHACSTGKS-----------------------------LNSLCDGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PEPEP--LKPKAEK
SA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDPAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPA------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKEGKLRVRTRAVREDDEDEDD
DKEDEVGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Rattus_norvegicus_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
AA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDTTQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLDDE---RELGPKDKEGKLRVHTRAVREDDEDEDD
DKEDEVGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Canis_familiaris_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------MVCGSDGHTYTS------------------
-KCKLEFHACSTGKS-----------------------------LNILCDGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PEPEP--SKHKTEK
NA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDGAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKLGKLRVHTRAVTEDDEDEDD
DKEDEVGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Bos_taurus_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-A---------------------CTDKELRNLASR---LKDWFGALHEDANRVINP---------------TSSETAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NELAGSRKQGAVN-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---QDLGPKDRLGKPRVHARAVTEDDEDEDD
DKEDEVGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Equus_caballus_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------MVCGSDGHTYTS------------------
-KCKLEFHACSTGKS-----------------------------LTTLCDGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PEPEP--PKHKAEK
NA---------------------CTDKELRNLASR---LKDWFGALHEDANRVIKP---------------TSSDTAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NELAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEDE---RELGPKDKLGKLRVHTRAVTEDDEDEDD
DKEDEVGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gallus_gallus_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--MVKCKPCP--------------------------------TVHAS---PVCGSDGHTYTT------------------
-KCKLEFHACTSGKT-----------------------------ITARCEGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PGPES--PKHKTEK
TA---------------------CTDKELRSLASR---LKDWFGALHEDANRVIKP---------------TSSETAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIS
AIYLDKY--EPCVKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSR---GKSLLG-----AFIPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NEIAGSRKQGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEEE---PEATKKDKEGKVKIHVRAANEDDEDEDD
DKDDEIGYIWTSEWGEPRRALCIHTTQTACWWGRCCWLRFNCRKTLRNKFTFSSPL------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Taeniopygia_guttata_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------AAWCFLQVESRHPEIITSNS--NHGNFLDNDKWLSTVSQYDKD
KYWNKFRDDDYF---------------------------RNWNPNKPFDQ--ALDPSKDPCLKVKCSPHKVCVTHDYETA
-----------------------------ICVSRKQLVH--------------------------RQKKGNLAQKHWAGA
ANVAKCKPCP--------------------------------VAHS---SAVCGSDGHTYSS------------------
-QCKMEFHACTSGKT-----------------------------ITTRCEGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PGPES--LKHKTEK
TA---------------------CTDKELRSLASR---LKDWFGALHEDANRVIKP---------------TSSETAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDP-----------------------SEIS
AIYLDKY--EPCVKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSR---GKILFG-----VFIPRCNEEGYYKATQCHD-----STGQCWC
VDKYG--NEIAGSRKRGTVS-CEEEQ-ETSGDFGSGG-SVVLLDDLEEE---PEATKKDKEGKLKIHVRAANEDDEDEDD
DKDDEIGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Pelodiscus_sinensis_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-IRNGEIISLKL---------------------------LTLLFLHLFLI--ALDPSKDPCLKVKCSPHKVCVTHDYETA
-----------------------------ICVSRKQLVHS------------------------LWQKKGNLAPKHWIGP
ANLVKCKPCP--------------------------------GTHSS---PVCGSDGHTYSS------------------
-KCKLEFHACTSAKT-----------------------------IAARCEGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PGQES--PKHKAEK
TA---------------------CTDKELRSLASR---LKDWFGALHEDANRVIKP---------------TSSDTAQG-
---------------------RFDTSILPICKDSLG-WMFNKLDMNYDLLLDH-----------------------SEIN
AIYLDKY--EPCIKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPG------GLPCQNEMNRIQKLSK---GKSLLG-----VFLPRCNEEGYYKATQCHG-----STGQCWC
VDKYG--NEIAGSRKQGTIS-CEEEQ-ETSGDFGSGG-SVVLLDDLEED---REGAKKDKEGKMKIHVRATNEDDEDEDD
DKDDEIGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Takifugu_rubripes_SPOCK1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------DATKDPCLKVRCPAHRVCISHDVQTA
-----------------------------ICTNRKQPAHS------------------------VKPRKGSTGHKHRLEA
SAHGKCRLCS--------------------------------ALQS---SPVCGSDGHPYSS------------------
-KCKLEFQSCISGKS-----------------------------ISVKCAGL----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PGQELRNAAPKAER
AGV------------------PCCENKELHSLAAR---LKDWFRILHLDTNRDLKSS--------------DNSDSTAG-
---------------------HFDTSILPICKDSLG-WMFNKLDMNFDLLLDQ-----------------------SELS
ALYLDKY--ETCMKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPE------GLPCQTEKTRIQSQ-----RKTLIG-----SYIPRCTDEGYFKPTQCHG-----STGQCWC
VDKYG--NEIAGSRKQGNPN-CDEEQ-ETSGDFGSGG-GVILLDDQEDE-PSQSGRSRQKKRRGRLHPRGTIEDDEDEDD
DKDDETGYTW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_SPOCK1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------DATKDPCLKVRCPPHRVCVSHDFQTA
-----------------------------ICTNRKQPAHRY-----------------------VKPRKGSTGHKHRVEA
GAHGKCRLCS--------------------------------VLQS---SPVCGSDGHSYSS------------------
-KCKLEFQSCISGKS-----------------------------ISVKCEGL----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PGRRAQNCS--AQR
TG---------------------CTDSELHSLAAR---LKDWFRVLHLDANRDLKSS--------------DNFDSTTG-
---------------------HFDTSILPICKDSLG-WMFNKLDINFDLLLDQ-----------------------SELS
ALYLDKY--EMCMKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPE------GLPCQSEKTRVQAQSQ---RKTLIG-----SYIPRCTDEGYFKSTQCHS-----STGQCWC
VDKYG--NEIAGSRKQGNPN-CDEDQ-ETSGDFASGG-GVILLDDQEEE-PSQSGRSRQKKRRGRIHPRGTIEDDEDEED
DKDDETGYTW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gasterosteus_aculeatus_SPOCK1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------MLLFLLPAVALLLSRESTVSGSGTDKWLSTVAQY-KD
RSWNRFRDDDYFKSWAPAKSLDQEREVEPGRQGDPGTKAHSGSAKKTAQD--GPDATKDPCLKVRCPPHKVCVSHDYQTA
-----------------------------ICTNHKQPPHS------------------------VKPRKGGAGHKHRLEA
GAHGKCRPCS--------------------------------GIQS---GPVCGSDGHTYSS------------------
-WCKLEFQSCLSGKT-----------------------------ISVKCDGP----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PGQQPSKPPHKTDK
AG----------------------TDTQLHSLAAR---LKDWFGVLHLDANRDLKSS--------------DSFDSTAG-
---------------------HFDTSILPICKDSLG-WMFNKLDMNFDLLLDQ-----------------------SELS
AIYLDKY--ELCMKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPE------GLPCQAEKSIIQNQSR---RKSLIG-----FYIPRCTEEGYYKPTQCHG-----STGQCWC
VDKYG--NEIAGSRKQGNPN-CDEDQ-ETSGDFGSGG-AVILLDDQEEE-PSRSGRSRQNKRRGRIHPRGAIEDDEDEED
DKDDEIGYVW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Oryzias_latipes_SPOCK1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------NDKWLGTGAQYNKD
RSWNRFRDVSCVG----------------------TTQEKLQFFASFLAS--GPDTTKDPCLRLHCPPHKVCVSHDFQTA
-----------------------------ICINQKQPGHR----------------------------KGSVNPKHRSEA
GAHGKCRLCS--------------------------------ALKT---SPVCGSDGHSYSS------------------
-KCKLDFHGCMSGKA-----------------------------VSVKCKGL----------------------------
-CPCL---------------------------------------------------------------------------
------------------------------------------------------------------PHYENIKSPHDTEK
TS---------------------CTDAELHSLAAR---LKDWFGVLHLDANRDLKS---------------DSFDSTAG-
---------------------HFDTSILPICKDSLG-WMFNKLDMNFDLLLDH-----------------------SELS
AIYLDKY--ELCMKP-----LFNSCD-SFKDG----------------------------------------------KL
SNNEWCYCFQKPE------GLPCQSEKSRIQSQSH---RKSLVG-----SYVPRCTEEGYYKPTQCHS-----STGQCWC
VDKYG--NEIAGSRKQGNPK-CDEDH-ETSGDFGSGD-AVLLLDDQEEE-PSQVGRSQQKKRRGR---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Ciona_intestinalis_SPOCK1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------MNVKTVILAVLVVGICTLCGTAEAKKRKRSQQAKLDLLPDEKLCARK
-----------------------------RCGRKPKGSWC-----------------------------QVVRDENGHRT
PTCVCPRSCN--------------------------------TTQIE---PVCSMYGRQYDS------------------
-ECLMHLEACKKRKN-----------------------------IKLAYEGP----------------------------
-CIAS---------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------QAKCQSHELQQFPFR---LLDWFVHLKDVDEFGSVDY----------------QKT----
----------------------VMSLSETDRKDVAQ-WKFQHLDRNKDGKLSN-----------------------KEIK
RFRFALMPLEHCAKH-----FFKKCDLDKN-----------------------------------------------RKL
SSDEWSECLVTRALT----WYQGRNEVNR---------------------------EESIQ-------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MRAPGCGR-LVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK
IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPTVKLHGNKDS
----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LAVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQAATSTAD-GKP
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SVAGPASG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC
VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gorilla_gorilla_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------FSSCSVFHGL
LLFPD--LQE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPTVKLHGNKDS
----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LAVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQAATSTAD-GKP
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SVASPASG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC
VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGC---------------------------------------EA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Macaca_mulatta_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MHAPGCGR-LVLPLLLLTAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK
IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPTVKLHGNKDS
----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSNKQ-----------------------------LAVRCDGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQAATSTAD-GKP
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SAASPASG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERVQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC
VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MRAPGSGR-LALPLLLLAVVALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK
IKHWNRFRD--E---------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCVAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPSLKLHGGKDS
----VCKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LAVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQSTASTTD-SKS
---------------------ETCTGQDLADLGDR---LRDWFQLLRENSKQNGSAN--------------SATNPAG--
----------------------LDKSLGASCKDSIG-WMFSKLDTSGDLFLDQ-----------------------TELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERTQIQEA---AKKKPG-----VFIPSCDEDGYYRKMQCDQ-----SRGDCWC
VDQLG--LELTGTRMHGTPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Rattus_norvegicus_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MRAPGSGR-LALPLLLLAVVALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK
IKHWNRFRDVSS---------------------VDDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCVAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPSLKLHGGKDS
----ICKPCH--------------------------------MAQLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSNKH-----------------------------LAVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQSTASTTD-SKS
---------------------ETCTGQDLADLGDR---LRDWFQLLRENSKQNGSAS--------------SSSSPAG--
----------------------LDKSLGASCKDSIG-WMFSKLDTSGDLFLDQ-----------------------TELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERTQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC
VDQLG--LELTGTRMHGNPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Canis_familiaris_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MRAPGCGR-LVLPLLLLAAAALAEGDAKGLKEGETPGNFMEDKQWLSSISQYSGK
IKHGTRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPTLKLPGNKDT
----ICKPCH--------------------------------MAPLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LTVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQASLSTTD-GKP
---------------------ETCTGQDLADLGDR---LRDWFQLLHENAKQNGSAG--------------SGANLASG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---SKKKPG-----IFIPSCDEDGYYRKLQCDQ-----SSGDCWC
VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GESDDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Bos_taurus_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MRARGCGR-LALPLLLLSAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK
IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPAVKLHGNKDT
----ICKPCH--------------------------------MAHLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LTVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQAATSTSD-SKP
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAN--------------SGASPASG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC
VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEETE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Equus_caballus_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MRAPGCGQ-LALPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK
IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPTLKVHGNKDS
----VCKPCH--------------------------------MAQLT---SICGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LTVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQAATSTAD-GKP
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSAS--------------SGASPASG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------MELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCDQ-----SSGDCWC
VDQLG--LELTGTRTHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Loxodonta_africana_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MRAPSCGR-LALPLLLLAAAALAEGDAKGLKEGETPGNFMEDEQWLSSISQYSGK
IKHWNRFRDE-----------------------VEDDYIKSWEDNQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPTLKLHGNKDT
----VCKPCH--------------------------------MAHLA---SVCGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LAVRCEGP----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQAATSTTD-GKP
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGSS---------------SGASPTTG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSADLFLDQ-----------------------TELA
AVNLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKRPG-----VFIPSCDEDGYYRKMQCDQ-----SSGDCWC
VDQLG--LELTGSRMHGSPDCD--DIVGFSGDFGSGVGS-----------------------------------------
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Monodelphis_domestica_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------MLPLGKLTSP-----------------------------------
--------EE-----------------------VEDDYIKSWEDSQQGDEA--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPALKLHENKEG
----FCKPCH--------------------------------MTQLA---SVCGSDGHTYSS------------------
-MCKLEQQACLTSKQ-----------------------------LTVKCEGQ----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEQAPASTTD-TKQ
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNGTAN--------------TGANPASG-
----------------------LDKSLGASCKDSIG-WMFSKLDTSNDLFLDQ-----------------------SELA
AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----VFIPSCDEDGYYRKMQCDQ-----GSGDCWC
VDQVG--QELTGTRLHGSPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Ornithorhynchus_anatinus_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------QDDYIKSWEDNQQGDEA--LDTTKDPCQNVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPALKLHGNRES
----FCKPCH--------------------------------MTQLA---SVCGSDGHTYSS------------------
-VCKLEQQACLTSKQ-----------------------------LTVKCEGQ----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TDHVPASTAD-GKQ
---------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNSSAA--------------PLVRPANG-
----------------------LEKGLGASCKDSIG-WMFAKLDTSSDLFLDQ-----------------------AELA
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLAELERIQIQEA---AKKKPG-----IFIPSCDEDGYYRKMQCNQ-----SSGECWC
VDQLG--MELTGTRVHGNPDCD--DLVGFSGDFGSGVGWEDEEEKEAEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Anolis_carolinensis_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------MRAMPAPGCCSSCLVPMLLLLLSLAWPTRSKPGKEGESPGNFMEDEQWLSSISQYSGK
IKHWNRFRD--------------------------DDYIKSWEDNQPVDEG--LDTTKDPCQKVKCSRHKVCIAQGYQRA
-----------------------------MCISRKKLEH--------------------------RIKQPALKPHGNKDS
----LCKPCH--------------------------------MTQLA---SVCGSDGHTYSS------------------
-VCKLEQQGCLTNKQ-----------------------------LTVKCEGP----------------------------
-CPCA---------------------------------------------------------------------------
------------------------------------------------------------------SDHSPTSATD-GKQ
---------------------ETCTGQDLADLGDR---LRDWFQLLHENAKQNSSGS--------------TGTNPVNV-
----------------------LDKSLVASCKDSIG-WMFSKLDTNSDLFLDQ-----------------------TELA
AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLVELERIQIQEA---AKKKPG-----AFIPSCDEDGYYRKMQCDS-----SSGECWC
VDHLG--TELTGTRMHGNPDCD--DIVGFSGDFGSGVGWEDEEEKETEE-----------------AGEEAE--EEEGEA
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Xenopus_tropicalis_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------MWNPGGSCLILLPLLLPIAWAQGDG-----KEVENTGNFMEDEQWLSSINQYSGK
IKHWNRFRD--------------------------DDYIKSWEDNQPGDEA--LDTTKDPCQKVKCSRHKVCIAHGYQKA
-----------------------------MCISRKKLEH--------------------------RIKQPSMKIHGNRDS
----LCKPCH--------------------------------VTQPA---AVCGSDGHTYSS------------------
-VCKLEQQACLSSKQ-----------------------------LTVKCQGS----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------TEHTPTTTTETGKQ
G--------------------ETCTGQDLADLGDR---LRDWFQLLHENSKQNNTSN--------------PGSKQVNV-
----------------------LDKSLVAGCKDSIG-WMFSKLDSNNDLFLDQ-----------------------AELA
AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------RV
STAEWCFCFWREK-------PPCLVELEKVQIQEA---AKRKPG-----VFIPSCDEDGYYRKMQCDQ-----ASGECWC
VDQHG--SELTGTRIHGNPDCD--DMVGFSGDFGSGVGWEDEEEKETED-----------------AGEEAE--EEEGET
GEADDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Danio_rerio_SPOCK2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MVWMNNPGCVLVPLLMLVRVAMQVDVKSGKEAEKTGNFMEDEQWLSTISQYSRK
IKHWNRFRD--------------------------DDYIRSWDENQGSNEN--VDTTKDPCQKVKCSRHKVCVAQGYQRA
-----------------------------VCVNRKKLEH--------------------------RLK--QQVIRQQQES
----NCKPCP--------------------------------VSSSG---PVCGSDGHNYAS------------------
-QCKLEQQACLAGKE-----------------------------LKVRCPGL----------------------------
-CPCT---------------------------------------------------------------------------
------------------------------------------------------------------ATTAPATD--VDGK
H--------------------ESCTGQDLADLGDR---LRDWFQLLQGNGKQNSTG--------------SPAASSASI-
----------------------VDRTLVATCKDSIG-WMFSKLDTNSDLYLDQ-----------------------AELA
AINLDKY--EVCIRP-----FFNSCD-SYRDG----------------------------------------------KV
STAEWCLCFWREK-------PPCLAELERIQLQEG---AKKKS-----DTYIPSCDEDGFYRRLQCDK-----SRGECWC
VDQHG--GELMGSRIHGNPDCD--EVVTYSGDFGSGLGWEDEEEKEAEE-----------------NGEEAE--EEEGEV
GEVDDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Takifugu_rubripes_SPOCK2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------CSANMVAARLVASLCLLAGFSLQVDVKSAKEAGKAGNFMEDEQWLSTISQYSRK
IKHWNRFRDE-----------------------VEDDYVKNGEENTASDET--VDTTKDPCQNVKCSRHKVCVAQGYQRA
-----------------------------MCVNRRKLEQ--------------------------KVR--QSGQSEGHEG
----SCKSCP--------------------------------VTATS---PVCGSDGHNYAT------------------
-ECKLEQQACLTGKD-----------------------------LSVMCSGF----------------------------
-CPCA---------------------------------------------------------------------------
------------------------------------------------------------------TS----TITEAKR-
---------------------DSCTGQDLADLGDR---LKDWFQLLHGNAKQNNSG--------------KLGSGTSSA-
----------------------LDRSLGASCKDSIG-WMFSKLDTNNDLYLDQ-----------------------SELT
AINLDKY--EVCIRP-----FFNSCD-TYKDG----------------------------------------------KI
SMAEWCLCFWRETE------PPCLAELERIQVQGA---AKMNP-----GMYIPSCDEDGYYRKVQCDQ-----SRGECWC
VDQHG--GELMGSRIHGNPDCD--EVAGYSGDFGSGVGWEDEEEKEAED-----------------IGEEAE--EEEEEE
GETDDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Takifugu_rubripes_SPOCK2_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MVGITNIACLLIPLVMLADSAFQSDLKTVKEAEKTGNFMEDEQWLSTISQYSRK
IKHWNRFRDE-----------------------VEDDYVRTWDENQGSNEN--VDTTKDPCQKIKCSQHKVCIAQGYQRA
-----------------------------VCINRKKLEH--------------------------RLK--QPALRSPNG-
----NCQPCP--------------------------------ISSTG---PVCGSDGHNYAS------------------
-KCKLEQQACLTGKD-----------------------------LTLKCTGL----------------------------
-CPCT---------------------------------------------------------------------------
------------------------------------------------------------------TAAPTPNS-SPLAS
T--------------------ESCTGQDLADLGER---LRDWFQLLQTNAKQNNNSKRG---------ARTTAASTTSV-
----------------------LDRSLVASCKDSIG-WMFSKLDTNGDLYLDQ-----------------------AELA
AINLDKY--EVCIRP-----FFNSCD-SYKDG----------------------------------------------KV
STAEWCLCFWREKE------PPCLTELERIQILDG---GKRKY-----GRFIPSCDEDGFYRKLQCD-------RGECWC
VDQNG--GEVAGTRTRGKTDCD--DEMAYSGDTGSAVGWEDEEEKEAEE-----------------TAEEAE--EEEGEV
GEVDDGGYIW----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_SPOCK2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MVEMTDLACLLVPLVMLADAAFQTDLKSVKEAEKTGNFMEDEQWLSTISQYSRK
IKHWNRFRDE-----------------------VEDDYVRTWDENQGSDDN--VDTTKDPCQKIKCSRHKVCIAQGYQRA
-----------------------------VCINRKKLEH--------------------------RQHSGQLVLHVQIAG
LLMETVSPAP--------------------------------SPPWG---PVCGSDGHNYAS------------------
-KCKLEQQACLSGKD-----------------------------LTLRCAGL----------------------------
-CPCT---------------------------------------------------------------------------
------------------------------------------------------------------TAAPTPKFFTPLAS
T--------------------ESCTGQDLADLGER---LRDWFQLLQTNAKQSNNSKPG---------ARAAAASTTSV-
----------------------LDRSLVASCKDSIG-WMFSKLDTNGDLYLDQ-----------------------AELA
AINLDKY--EVCIRP-----FFNSCD-SYKDG----------------------------------------------KV
STAEWCLCFWREK-------PPCLTELERIQILDG---GKRKYV---QGQFISSCDEDGFYRKLQCD-------RGECWC
VDQNG--GEVAGTRTRGKTDCD--DEMAYSGDTGS---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_SPOCK2_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------A--VDTTKDPCQNVKCSRHKVCVAQGYQRA
-----------------------------MCVNRRKLEQ--------------------------KVQ--QPGQPEGHER
----SCKSCP--------------------------------VTVPS---PVCGSDGHNYAS------------------
-ECKLEQQACLTGKD-----------------------------LSVMCTGF----------------------------
-CPCA---------------------------------------------------------------------------
------------------------------------------------------------------AS----TITESKRG
GQSI---------------KRNSCTGQDLADLGDR---LKDWFQLLHGNAKQNNSG--------------RPGSGTSSA-
----------------------LDRSLGASCKDSIG-WMFSKLDTDSDLYLGQ-----------------------AELT
AINLDKY--EICIRP-----FFNSCD-TYKDG----------------------------------------------KI
SMAEWCLCFWRETE------PPCLAELEKIQVQGA---AKMNP-----GMYIPSCDEDGYYRKVQCHQ-----SRGECWC
VDQHG--GELMGSRIHGNPECD--EVAGYSGDFGSG--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gasterosteus_aculeatus_SPOCK2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------ATMVGITDIACLLVPLAVLAGSTFQTDVKGVKEAEKTGNFMEDEQWLSTISQYSRK
IKHWNRFRDE-----------------------VEDDYVRTGEESQGSNDN--VDTTKDPCQKVKCSRHKVCVAQGDQKA
-----------------------------VCVNRKKLEH--------------------------RLK--QPALRSPDG-
----NCQPCP--------------------------------ISSAG---PVCGSDGRSYAS------------------
-KCKLEQQACLIGKD-----------------------------LTLKCSGL----------------------------
-CPCA---------------------------------------------------------------------------
------------------------------------------------------------------TAAPASTE--TIHA
T--------------------EGCTGQDLADLGER---LRDWFQLLQGNAKQNNNSKTG---------ARTTAASSTSV-
----------------------LDRSLVASCKDSIG-WMFSKLDTNGDLYLDQ-----------------------AELA
AINLDKY--EVCIRP-----FFNSCD-SYRDG----------------------------------------------KV
STAEWCLCFWREK-------PPCLAVLERIQVLDG---GKRKF-----GRFIPSCDEDGFYRKQQCD-------RGECWC
VDQNG--GKVAGSRMRGKPDCGTMMKMAYFSYFGQGVWDGKNEEKKGRQ--------------------GVE--EEEGEG
EEVITGGPIG----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gasterosteus_aculeatus_SPOCK2_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------SYVCNYSGR
LFSIHHLKLY-----------------------WKDDYIKNMEQNIGSDET--VDTTKDPCQNVKCSRHKVCVAQGYQRA
-----------------------------MCVNRKKMEQ--------------------------RVK--QSGQPEARES
----GCKPCP--------------------------------VVSSSS--PVCGSDGHNYAS------------------
-QCKLEQQACLASKE-----------------------------LSAACAGF----------------------------
-CPCA---------------------------------------------------------------------------
------------------------------------------------------------------TASVSLSNTDTKPP
--------------------SESCTGQDLADLGDR---LRDWFQLLHVNAKQNNSG--------------KLRGDTASA-
----------------------LDKSLAASCKDSIG-WMFSRLDTNSDLYLDQ-----------------------AELT
AINLDKY--EVCIRP-----FFNSCD-SYKDG----------------------------------------------KV
STAEWCLCFWRE-K------PPCLAELERIQVQEA---AKKKP-----GVYIPSCDEDGYFRKVQCDQ-----SRGECWC
VDQHG--GEMMGTRIHGNPDCD--EAAGYSGDLGSGVGW-----------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Oryzias_latipes_SPOCK2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------VKCSQHKVCVAQGYQRA
-----------------------------MCVSRKKLEH--------------------------RIK--QSEQLERHES
----NCAPCA--------------------------------EAASS---PVCGSDGHNYAS------------------
-QCKLELQACLTGKD-----------------------------LSIMCTGF----------------------------
-CPCV---------------------------------------------------------------------------
------------------------------------------------------------------TS--SLSNSDTKR-
--------------------AESCTGQDLADLGDR---LRDWFQLLHGNAKQNKSG--------------QPGTGTVSV-
----------------------LERSLIASCKDSIG-WMFSKLDTNSDLYLDQ-----------------------AELA
AINLEKY--EVCIRP-----FFHSCD-SYKDG----------------------------------------------KV
STAEWCLCFWRETE------PPCLAELERIQVQEA---AKKKP-----GIYIPSCDEDGYYRKVQCDQ-----SRGECWC
VDQHG--GEIMGSRIHGNPDCD--EVAGYSGDFGSG--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Apis_mellifera_SPOCK2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------MPFVSFSS----LQDDKSSQQQPLDSG----LSMQMKQDQQ--QMIPEKKKWI
HDPSSDLCKPLNCK--------------------KKELCLLEDAYTAVCVSKKELHKNKEE--------IITKSKYFDEE
EAKRKAEAEAAA---------------------AAAAAAAATG-LGGAVGSGVAGAADTGSMTLMAASGDSSTGSNANDG
-----------------------------TSSGLEHEEREDD---ESSSQDDD-----------------VFYDSEKEED
-----CKPCP--------------------------------VVKPT---YLCGSDNWTYSS------------------
-LCRLEYHNCIHTTE-----------------------------VKVNCMGF----------------------------
-CPCK----GKRWQ----------------QQQQQQQLK----------------------------------------E
EKNRHYNHINSQYTFTPEEIKYDNKHYKYIKYTTYKGKYDGYGSSGSGSTRMTGEDKHKIRGYNEVLDKPASTSNNNGNS
KPSKLSGS----------SARNECKPQQLTAIGNR---LLDWFSVIMADSKKRRQHQQQ---------------------
---------------------KNKVHFPAACKLEAR-WMFGHLDLNNDGELST-----------------------QELY
DLEHDQN--ERCIKP-----FIDTCD-LDQDN----------------------------------------------TI
DPREWCRCFEKTDR-------PCAAVRRRLGNDLSG-------------SYAPDCDSQGFYKPTQCHQ-----AVGVCWC
VDEHG--VEFANTRTRG-KPNCEEIINNATT--LNSD----DEDTEDSDDD-----------------------DDSQEG
SADRLLVF------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_SPOCK3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKE
VG-QWNKFR----------------------DEVEDDYFRTWSPGKPFDQ--ALDPAKDPCLKMKCSRHKVCIAQDSQTA
-----------------------------VCISHRRLTH--------------------------RMKEAGVDHRQWR-G
PILSTCKQCP--------------------------------VVYP---SPVCGSDGHTYSF------------------
-QCKLEYQACVLGKQ-----------------------------ISVKCEGH----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------SDKPT--STSRNVK
R---------------------ACSDLEFREVANR---LRDWFKALHESGSQNKKTK--------------TLLRPERS-
---------------------RFDTSILPICKDSLG-WMFNRLDTNYDLLLDQ-----------------------SELR
SIYLDKN--EQCTKA-----FFNSCD-TYKDS----------------------------------------------LI
SNNEWCYCFQRQQ------DPPCQTELSNIQKRQG---VKKLLG-----QYIPLCDEDGYYKPTQCHG-----SVGQCWC
VDRYG--NEVMGSRINGVAD--CAIDFEISGDFASGDFHEWTDDEDDED---DIMNDEDE-----IEDDD-EDEGDDDDG
-GDDHDVYI-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Macaca_mulatta_SPOCK3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MLKVSAVLCVCAAAWCSQSLAAAAAVAAAGGRSDGGNFLDDKQWLTTISQYDKE
VG-QWNKFR----------------------DEVEDDYFRTWSPGKPFDQ--ALDPAKDPCLKMKCSRHKVCIAQDSQTA
-----------------------------VCISHRRLTH--------------------------RMKEAGVDHRQWR-G
PILSTCKQCP--------------------------------MVYP---SPVCGSDGHTYSF------------------
-QCKLEYQACVLGKQ-----------------------------ISVKCEGH----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------SDKPT--STSRNVE
R---------------------ACSDLEFREVANR---LRDWFKALHESGSQNKKTK--------------TLLRTERS-
---------------------RFDTSILPICKDSLG-WMFNRLDTNYDLLLDQ-----------------------SELR
SIYLDKN--EQCTKA-----FFNSCD-TYKDS----------------------------------------------LI
SNNEWCYCFQRQQ------DPPCQTELSNIQKRQG---VKKLLG-----QYIPLCDEDGYYKPTQCHG-----SVGQCWC
VDRYG--NEVMGSRINGVAD--CEP-HSFVQAFNHGDFHEWTDDEDDED---DIMNDEDE-----IEDDD-EDEGDDDDG
-GDDHDGYI-----------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_SPOCK3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------MLKVSALLCVCAAAWCSQTLAAAAAVAVAGGRSDGGNFLDEKQWLTTISQYDKE
VG-QWNKFR----------------------DEVEDDYFRTWNPGKPFDQ--ALDPAKDPCLKTKCSRHKVCITQDAQTA
-----------------------------LCISHRRLTH--------------------------SMKEVGGSHKQWR-G
LPSSTCKPCP--------------------------------IAYA---SPVCGSDGHSYSS------------------
-QCKLEYQACVLGKQ-----------------------------ISIKCEGR----------------------------
-CPCP---------------------------------------------------------------------------
------------------------------------------------------------------SDKSM--NIGRNVK
R---------------------ACSDLEFREVANR---LRDWFKALHESGSQNKKTK--------------ALLRPERS-
---------------------RFDTSILPICKDSLG-WMFNRLDTNYDLLLDQ-----------------------SELG
SIYLDKN--EQCTKA-----FFNSCD-TYKDS--------------------------------------------