>Homo_sapiens_RHOH
--------------------------------------------------------------------------------
----------------MLSSIKCVLVGDSAVGKTSLLVRFTSE-----------TFPEAYKPTVY--ENTGVD-------
--VFMDGIQISLGLWDTAG--------------------------NDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKN
KWIGEI------------RSNLPCTPVLVVATQTDQREMGPHRASCVN----------------------------AMEG
KKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARR-----------------RNRR-------------------
---------RLFSINECKIF------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Pan_troglodytes_RHOH
--------------------------------------------------------------------------------
----------------MLSSIKCVLVGDSAVGKTSLLVRFTSE-----------TFPEAYKPTVY--ENTGVD-------
--VFMDGIQISLGLWDTAG--------------------------NDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKN
KWIGEI------------RSNLPCTPVLVVATQTDQRETGPHRASCVN----------------------------AMEG
KKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARR-----------------RNRR-------------------
---------RLFSINECKIF------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_RHOH
--------------------------------------------------------------------------------
----------------MLSSIKCVLVGDSAVGKTSLLVRFTSE-----------TFPEAYKPTVY--ENTGVD-------
--VFMDGIQISLGLWDTAG--------------------------NDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKN
KWISEI------------RSNLPCTPVLVVATQTDQREVGPHRASCIN----------------------------AIEG
KRLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARR-----------------RNRR-------------------
---------KLFSINECKIF------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gallus_gallus_RHOH
--------------------------------------------------------------------------------
----------------MLDSIKCVLVGDSAVGKTSLLVRFISD-----------TFPDNYRPTVY--ENTGVD-------
--VFMDGVQISLGLWDTSG--------------------------SDAFKGIRPLSYQQADVVLMCYSVANHNSFLNLRS
KWIGEI------------RNHLPRIPVLVVATQTDQRDTGPYRSSCIS----------------------------SMDG
KRLAQDVRAKGYLECSALSNRGVQQVFEYAVRTAVNQAKR-----------------QNRR-------------------
---------KLFSINECKIF------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Xenopus_tropicalis_RHOH
--------------------------------------------------------------------------------
----------------KMNSIKCVLVGDAAVGKTALLVRFTSE-----------AFPDSYRPTVY--ENTGVD-------
--VYMDGVQISLGLWDTAG--------------------------NDAFRSIRPLSLQNADIVLLCFSVANHTSFLNVRN
KWIGEV------------RQHLPRIPVLVVATQTDQRELDHMRLPCIN----------------------------SIDG
KQLAQDVRAKGYLECSALSNRGVQQVFECAVRTAINQAKK-----------------RARR-------------------
---------HRFLSQECKIF------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Takifugu_rubripes_RHOH_a
--------------------------------------------------------------------------------
------------------MSIKCVLVGDNAVGKTALLVRFTSE-----------TFPESYRPTVF--DNTGVE-------
--VYMDGVHISLGLWDTAG--------------------------NDTFQQIRPRSYQQADIVLICYSVANPNSLANVHK
KWLPEV------------REHLPNVPVLVVATQTDLREMGAYRGNCTT----------------------------SAEG
AQMAREIKAKGYVECSAFSNRGVQQVFEYAVRIVVNQAKK-----------------QARR-------------------
---------RMFRINQCKVF------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_RHOH_a
--------------------------------------------------------------------------------
------------------MSVKCVLVGDSAVGKTALLVRFTSE-----------TFPESYRPTVF--DNTGVE-------
--VYMDGVHISLGLWDTAG--------------------------NDNFQQIRPRSYQQADIVLICYSVANPNSLANVQN
RWIPEV------------RQNLPKVPVMVVATQTDLREMGAYRGNCIT----------------------------AAEG
AQVAREIKAKGYVECSAFSNRGVQQVFEYAVRIAVNQAKK-----------------QARR-------------------
---------RMFSINQCKVF------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Anopheles_gambiae_RHOH
--------------------------------------------------------------------------------
-------------MSS-GRPIKCVVVGDGTVGKTCMLISYTTD-----------SFPGEYVPTVF--DNYSAP-------
--MVVDGVQVSLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLICYSVASPSSFENVTS
KWYPEI------------KHHCPDAPIILVGTKIDLREDRETISLLAD---------------------QGLSALKREQG
QKLANKIRAVKYMECSALTQRGLKQVFDEAVRAVLR-PEP-----------------LKR--------------------
------------RQRKCVVM------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_RHOBTB2
---------------------------------------------------------------MQAWRKGPDGPQKTSSD
SMSRLMDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT
MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKPNEILPPEKG
REVAKELGIP-YYETSVVAQFGIKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSS
EECPAHLLEDPLCADVILVLQE-RVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQH--HHH
HHHHHGRDFLLRAAS-FDVCESVDEA---------------------------------------------G-GSGPAGL
RAST-----SDGILRGN----GTGYLPGRGRVLSSW-----------------------SRAFVSIQEE-MAEDPLTYKS
RLMVVVKMDSSIQPGPFRAVLKYLYTGELDENERD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR
TNRVKECLA-KGTFSDVTFILDDGTISAHKPLLISSCD-WMAAMFGGPFVESSTREVV-FPYTSKSCMRAVLEYLYTGMF
T---SSPDLDDMKLIILANR-LCLPHLVALTEQYTVTGLMEATQM-MVDIDGDVLVFLELAQFHCAYQLADWCLHHICTN
YNNVCRKFPRDMKAM-SPENQ----EYFEKHRWPPVWYLKEEDHYQRARKEREK----------------EDYLHLKRQP
KRRWLFWNSPS---SPSSSAASSSSPSSSSAVV-----------------------------------------------
----------------
>Pan_troglodytes_RHOBTB2
--------------------------------------------------------------------------------
-----MDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT
MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKPNEILPPEKG
REVAKELGIP-YYETSVVAQFGIKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSS
EECPAHLLEDPLCADVILVLQE-RVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQQ--HHH
HHHHHGRDFLLRAAS-FDVCESVDEA---------------------------------------------G-GSGPAGL
RAST-----SDGILRGN----GTGYLPGRGRVLSSW-----------------------SRAFVSIQEE-MAEDPLTYKS
RLMVVVKMDNSIQPGPFRAVLKYLYTGELDENERD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR
TNRVKECLA-KGTFSDVTFILDDGTISAHKPLLISSCD-WMAAMFGGPFVESSTREVV-FPYTSKSCMRAVLEYLYTGMF
T---SSPDLDDMKLIILANR-LCLPHLVALTEQYTVTGLMEATQM-MVDIDGDVLVFLELAQFHCAYQLADWCLHHICTN
YNNVCRKFPRDMKAM-SPENQ----EYFEKHRWPPVWYLKEEDHYQRARKEREK----------------EDYLHLKRQP
KRRWLFWNSPS---SPSSSAASSSSPSSSSAVV-----------------------------------------------
----------------
>Mus_musculus_RHOBTB2
--------------------------------------------------------------------------------
-----MDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT
MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKPNEILPPEKG
REVAKELGIP-YYETSVVAQFGIKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSS
EECPAHLLEDPLCADVILVLQE-RVRIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSGSGGPRPEDHRSHPEQH--HHH
HHHHHGRDFLLRAAS-FDVCESVDEA---------------------------------------------G-GSGPAGL
RAST-----SDGILRGN----GTGYLPGRGRVLSSW-----------------------SRAFVSIQEE-MAEDPLTFKS
RLMVVVKMDNSIQPGPFRAVLKYLYTGELGENERD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR
TNRVKECLA-KGTFSDVTFILDDGTISAHKPLLISSCD-WMAAMFGGPFVESSTREVV-FPYTSKSCMRAVLEYLYTGMF
T---SSPDLDDMKLIVLANR-LCLPHLVALTEQYTVTGLMEATQM-MVDIDGDVLVFLELAQFHCAYQLADWCLHHICTN
YNNVCRKFPRDMKAM-SPENQ----EYFEKHRWPPVWYLKEEDHYQRARKEREK----------------EDYLHLRRQP
KRRWLFWNSPS---SPSSSAAGSASPSSSSSAVV----------------------------------------------
----------------
>Xenopus_tropicalis_RHOBTB2
------------------------------------------------------------------------------CL
IRSQLLDTDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLQHVQT
MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLAS---------RPIRPQEILPPEKG
REVAKELGIP-YYETSVVAQCGIKEVFDNAIRSALISRRH-LQFWKSHLRSVRRPLPQAPFLPPRPPPPVIIVPDPPTKS
EDHPARLLEEASCADVVLVVQE-RIRIYAHRIYLSTASSKFCDLFLMEDGDSP---------------------------
---TQTRDPLLRASS-FDACEVSGES---------------------------------------------E----GAGM
RASA-----SDGTLGRE-----------CGRDLSSW-----------------------SRAFESIHSG-VLEEPPGYRA
RRVAVVKMDSSVRPGPFRAVLKFLYTGRLDEREPD---LMEVAHIAELLEVFDLRMMVANILNREAFMNQEITRAFHVRR
SNRVKECLA-KGTFSDVTFMLDDGSIKAHKPLLISGCD-WMAAMFGGPFLESSTTEVV-IPYTSRGSMRAVLEYLYTGQF
SYRISSTNPLDCKHTQTAIG-YPLPHLVALTEQHTVSVMLDASLN-NKDIDGEALMLLEAAQFHGADQLAAWCMHHISTN
YNRVCRKFPRDIKAV-SAENQ----QALETQRWPPVWYLKEEDHFQRAQREREK----------------ETALHQKRQP
KRRWLFWNNSR--------AGSSATPTPSSSAV-----------------------------------------------
----------------
>Danio_rerio_RHOBTB2_a
--------------------------------------------------------------------------MHPFSS
LRSQFTDTDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLFHVKT
MWYPEIKH------------FCPRAPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKANEILPPEKG
REVAKELCVP-YYETSVVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLRDVQRPLLQAPFLPPKPPPPVITVPPAPSPT
DEHPGRLLEEPLCADVLLVLQE-HHRVFAHKVYLATASSKFYDLFVQDSVLGR-ESPAQADSFDIEN-------------
----------STSHQ-HPVSESIDED---------------------------------------------S----TVKM
RACI-----SDGTLTND----APLEMSHGGRLSSAL-----------------------GRAFISMRRE-SVQDPVTLVS
RPMTVVHLDPSVLFGPFAVVLRYLYTGRLDENEKD---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR
TNRVKECLA-KGTFSDVVFQLDDGTVEAHKPLLISSCD-WMAAMFGGPFVESSTKEVL-FPNTSRSSMQAVLEYLYTGRF
C---SRPDLDTMELIILANR-LCLPHLVALTELHTVTVLKESAAA-GTDIDGDVLLYLEMAQFHCAEQLTSWCLHHICTN
YNNVCRKFPRDMRAK-SAENQ----EYFEKQRWPPVWFLKEDDHYQRALKERQQ----------------EDSLNLKRQS
RRRWTLRSIQSP--APPSSPSSSPSSSGSSAII-----------------------------------------------
----------------
>Danio_rerio_RHOBTB2_b
--------------------------------------------------------------------------------
-----MDIDTDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSLANPNSLRHVRT
MWFPEIKH------------FCPRTPIILVGCQLDLRYADLDAVNRA----RRPLA----------KPIKPTDILPPERG
HEVAKELGVP-YYETSIVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLKKVQRPLLQAPFLPPRPPRPVVGIPDPPPAD
GEAPDSLFCQPLCADVLFLLQAGTTRVFAHKVYLATSCSKFYDLFTMDLG-----AAG-MENEHEESSEGSEEEEQ----
-SRRGAKEQAGRTKS-LDIEKEG-DG---------------------------------------------GTRGANRLL
MLQQGSLRTSQSDNALPAKGQYSAGTLGAGRALLGW-----------------------GRGFLGVYLE-MVDDPVTGRP
RLMTVVSMDDLIQKGPFQAVLQYLYTGHLDERRGD---LMQVATIAELLEVFDLRMMVANVLNRESFMNQEITKAFHVRR
ANRIKECLS-KGTFADVVFQLDDGYLPAHKPLLISSCD-WMAAMFRGSFMESYIEEVS-IPNTSCACMRAVLEFLYCGVL
T---PSSELEPMDLIILANR-LCLPRLVALTEQHAVEDLLQLSVK-GLDIDGHVLAYLEMAQFHNAKQLSAWCLHHICTN
YNSVCRKFPKDMKIM-SPENQ----KHFEKYRWPPVWFLKEEDRYLRSQKERER----------------EEEILRKQHT
KRGWCFWRHPS------SSAPHIS--------------------------------------------------------
----------------
>Takifugu_rubripes_RHOBTB2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------VS----------RPIKSNEILPPERG
REVAKELGVP-YYETSVVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPLITVPPPPTTT
EEHPVGLLEDPHCADVILVLQE-RQKIFAHKIYLATSSSKFYDLFILDVQNAASERPA----------------------
RAPLSGRELLMRAAS-FDVCESNDDG---------------------------------------------D----RANL
RACT-----SDGTLKDF-------EGSRRGRMLSSW-----------------------SRAFVSIQEE-LVEDPVTYGP
RPMTVVHMDQSMQLGPFRAVLRYLYTGQLDENEKE---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR
TNRVKECLA-KGTFSDVVFKLDDGTIMAHKPLLISSCD-WMAAMFGGPFVESCTKEVL-FPNTSRSSMRAVLEYLYTGRF
C---SRPDLDAMELIVLANR-LCLPHLVALTELYTVTVLTEAAMM-GPNIDGDVLLYLDMAQFHGAQQLTGWCLHHICTN
YNSICRKFPRDMKAK-SADNQ----EYFEKHRWPPVWYLKEDDHYQRARRERDK----------------EDYLYQRRQC
KRKWLFWNLPS---SPSSHSPSSGSSAVI---------------------------------------------------
----------------
>Takifugu_rubripes_RHOBTB2_b
------------------------------------------------------------------------------LF
SRALSMDIDTDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSLANPNSLRHVRT
MWFPEIKH------------FCPRTPIILVGCQLDLRYADLDAVNRA----RRPLA----------KPIKPTDILPPERG
HEVAKELGIP-YYETSIVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLKKVQRPLLQAPFLPPRPPRPIIGIPDPPPTD
GEGPDSLFCQPLCADVLFLLQAGSTRVFAHKVYLATSCSKFYDLFTLDLGGSFVVQKG-EDEENKENFESGEEDEQ----
-SRRGAKEQAGRTKS-LDIDKDGVDG---------------------------------------------GVRGLNRPQ
LLQQGSLRTSQSDNALPSRAIYSLGALGTGRALSGW-----------------------GRGFLSVCLE-HVDDPVTGRP
RLMTVVAMDALIQEEPFKAVLQYLYTGSLDEGRGD---LMQVATIAELLEVFDLRMMVANVLNRESFMNQEITKAFHVRR
ANRIKECLN-KGTFADVVFRPDDGCLPAHKPLLISSCN-WMAAMFRGSFMESYIEEVP-IPNTSTACMRGVLEFLYSGLL
T---PCPGLEPMELIVLANR-LCLPRLVALTEQHAADELLQLAVK-GGDIDGQVLAYLEVAQFHNAKQLSAWCLHHICTN
YNSICRKFPKDMKAM-SSENQ----RHFEKHRWPPVWFLKEEDRYLRSQKERER----------------EEEILRKQHT
KRGWCFWRHPS------S--------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_RHOBTB2_a
------------------------------------------------------------------------------IF
SRALSMDIDTDYERPN-VETIKCVVVGDNAVGKTRLICARACNATLTQ-----YRLP-RDVPTVWAIDQYRVCQEVVLER
SRDVVDEVSVSRRVWDTFW----------------------------RSSQEHRFSPSRSDVVVLCFSLANPNSLRHVRT
MWFPEIKH------------FCPRTPIILVGCQLDLRYADLDAVNRA----RRPLA----------KPIKPTDILPPERG
HEVAKELGIP-YYETSIVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLKKVQRPLLQAPFLPPRPPRPIIGIPDPPPVD
GEGPDSLFCQPLCADVLFLLQS-SIRVFAHKVYLATSCSKFYDLFTLDLGGSCVVQQR-EEDENKENFESGEEDEQ----
-SRRGAKEQAGRTKS-LDIDKDGVDG---------------------------------------------GVRGLNRPQ
LLQQGSLRTSQSDNALPSRAIYSVGALGTGRTLLGW-----------------------GRGFLSVCLE-HVDDPVTGRP
RLMTVVAMDALIQEEPFKAVLQYLYTGSLDEGRGD---LMQVATIAELLEVFDLRMMVANVLNRESFMNQEITKAFHVRR
ANRIKECLN-KGTFADVVFRPDDGCLPAHKPLLISSCN-WMAAMFRGSFMESYIEEVP-IPNTSTACMRGVLEFLYSGLL
T---PCPGLEPMELIVLANR-LCLPRLVALTEQHAADELLQLAVK-GGDIDGQVLAYLDVAQFHNAKQLSAWCLHHICTN
YNSICRKFPKDMKAM-SSENQ----RHFEKHRWPPVWFLKEEDRYLRSQKERER----------------EEEILRKQHT
KRGWCFWRHPS------S--------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_RHOBTB2_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------EILPPERG
REVAKELGVP-YYETSVVAQFGVKDVFDNAIRAALISRRH-LQFWKSHLRNVQRPLLQAPFLPPKPPPPIITVPPPPTTT
EEHPVGLLEDPHCADVILVLQE-RQKIFAHKIYLATSSSKFYDLFIMDMQNEESDRPI----------------------
RGPLSGRELLMRAAS-FDVCESSDDG---------------------------------------------D----RANL
RACT-----SDGTLKDF-------EGGRRGRVLSSW-----------------------SRAFVSIQEE-LVEDPVTYSP
RPMTVVHMDQSMQLGPFRAVLRYLYTGQLDENEKE---LMHIAHIAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRR
TNRVKECLA-KGTFSDVVFKLDDGTIMAHKPLLISSCD-WMAAMFGGPFVESCTKEVL-FPNTTRSSMRAVLEYLYTGRF
C---SRSDLDAMELIVLANR-LCLPHLVALT-----------------------------AQFHGAQQLTGWCLHHICTN
YNSICRKFPRDMKAK-SADNQ----EYFEKHRWPPVWYLKEDDHYQRARKERDK----------------EDYLYQRRQC
KRKWLFWNLPS---SPNSH-------------------------------------------------------------
----------------
>Branchiostoma_floridae_RHOBTB2
--------------------------------------------------------------------------------
-------MALLNQRPHLVELVKCVVVGDNAVGKTRLICARACATPITK-----QQLLATHVPTVWAIDQYQISPQI-LER
SYDIVDGVHVSLRLWDTFG----------------------------DHEKDRRFAYGRSDVVLLCFSIANPTSLKHAML
MWYPEIKQ------------FCPHAPIILAGCQADLRYADLDLYNKH----KGPFA----------RKVKPSDIMMPDEG
RSVAKELGIP-YYETSIVDNYGIRDLFHNVTRAALLARRS-FLFWKSNLKKVQKPLLQLPFLPPPPPLPIITVP--LNTH
VEELRDFFHNPGCSDVTFLAQG--VRIPANKVFLVAASPFFKDLFMMDLS------------------------------
------QDLANQTHLDNDPCKDKGLS---------------------------------------------RTTNLHVTK
SQLG-----GQGDVNGNG---TTDFHGFPSHILEHS-----------------------VIHSIHLANQ-SDPFVESERP
TLHTFVTLNPSVLPKAFQHCLEFLYTGHLEEKGLP---LTEMLHLAKELQMVVLVEMVRNHLNEEEFMNSEVTFRFHKRR
NSGLKDMLS-KGLLSDVVFRVDDGTVTAHKPLLMAHCD-VMSAMFGGNFLESSIKEVP-LPGTTKACLQALLEYLYTGQL
S---LPANRDCIGLIELANR-ICLPRLVALTEHHIVLELSRAREN-NQDIHLEVLMLLEPAQLHNACQLSAWCVSHITTN
YKHICRRYSKELHTL-TPETQ----QYVAKHRWPPIWYLKERDYYDKAQRERERAEE-------------KKAALQKVKR
VKKWCF--------------------------------------------------------------------------
----------------
>Strongylocentrotus_purpuratus_RHOBTB2
--------------------------------------------------------------------------------
---------MDNELPR-QELVKCVVVGDSAVGKTRLIVARATNQAMTR-----SQLFQTHIPSVWAIDQYRMCQEV-LEN
SWETIDGVSVSLRLWDTFG----------------------------DHEKDRQFAYGRADVVLLCFSIADAISLKNVKK
KWLPEIRH------------FCPRAPIIMCGCKNDLRYADLEALKKE----RGPVSHQCS----RHRAFDPEGILPPKEG
RNIAKESNLV-YYETSSYTLYGVQEVFDNVVRAALIYRRQ-HRFWQSNLKKVQKPLLQAPYLPGCPRGPCIHIPESTYAT
--DISILLKEPACADVIFTAHG--ESICAHKVCLLAASPIFSELFLDDEKDIELSKQS--SSSGSNSSNENQSQAKDILQ
QHHHHTAHQSPRSESPMCCHSPTPDRSQSPDCNHENICPSPPLGLHPNCNTLLAEDQCLSISPNGNTCLFSGSAQHKNCS
KAAPTTMGSSSPLHHHHQQTSTPTRLRSSSPSIRSSPLQQINTPTVPANLQCLPTKTLKHQAFNSIHLQ-QVTDSLGGRT
TQRHIVVLNPKITAEAFRAVLEFLYTGSLDIKVYSS--LSDIITAASLLDLSDLVAFVANVKNQDEFLNADLVDNFLHRR
KERFAKLFANQGLLSDLVINVEDGQVKSHKCLVMVRCD-PMLAMLSGNFKESS-SEVS-MKTFKKATFELFLEYLYTDQC
H---MESNSDALAVLELANF-LCLPHLVALCEKSVVHELQSSMET-QDVLDEAVVSVLQIAKLHNAHQLHSWCIHYMTIR
FIDVQKGRPKLFKEL-APEYR----KQIERQRWPPAYYLDEAAYFEKCLAELKK-------------------GNDIRTK
KHKWCLR-------------------------------------------------------------------------
----------------
>Hydra_magnipapillata_RHOBTB2
----------------------------------------------------------------------------MDID
SWPASSNSFDAYDNKPSEEFIKCVVVGDTAVGKTRLICSYIFDQPPTS---IQSLHLKPHIPTVFAIDQYVGNSDI-RKR
GKTVIDGVNVELRIWDTFG----------------------------DHEKDRKYAYENAHVVVVCFSIGMQSSLINVNA
KWVPEIKK------------YCPRAAIVLVGTQLDRRYTNPEMYKNALQVTTLTNILNTGGRFKLHSGFSMSDIIYAETA
RQISKEIKAACYIEVSVVSKHGVNAVFENSIRAALILRRNSKLILKSHLKNIKTPHIQEPYLPPCPEAPDINILAEGEMF
DFSCLHSVSS--FCDIEFIVEN--EHLHAHSVVLISADEVFQSLLMHPFILDLLG-------------------------
--FPKGKNIQNFESFSLEYAPING--------------------------------------------------------
------------------------------------------------------------VLCYGIPRGFSSISVVTDFN
LKRKVTVNVSQVTAVSFRNILEFVYCGSISNIKDS----AQLLTNATYLQLSMLCNYLTSSIEESSQLKNTFYQMLFKKR
KKILLNFVFNKSLYSDISFSMEGALIPSHKPLLVVQCN-VMAGMFRKKTFKESITHVVDFSNCDKESFMTVLEYLYTCDL
CN-----HGDLHNVLQLANF-LCLPRLITLCELELTKKITEVNSNQCDEACALVLDTFIFAKFHNAVQLSDWCLYFMASN
YNKMCQYQGREMKALDETTKN-----YLEKNRWPPVWYLKDQDLYERCMQKIEK----------------ENTFKISKER
KESRCFSFFKNL--------------------------------------------------------------------
----------------
>Homo_sapiens_RHOBTB1
--------------------------------------------------------------------------------
-----MDADMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKS
MWYPEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG
REVAKELGLP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMG
TNEAACLLDNPLCADVLFILQD-QEHIFAHRIYLATSSSKFYDLFLMEC---------------EESPNGSEGACE----
-KEKQSRDFQGRILS-VDPEEEREE----------------------------------------------GPPRIPQAD
QWKS----SNKSLV--EALGLEAEGAVPETQTLTGW-----------------------SKGFIGMHRE-MQVNPISKRM
GPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKD---LVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRK
ANRIKECLS-KGTFSDVTFKLDDGAISAHKPLLICSCE-WMAAMFGGSFVESANSEVY-LPNINKISMQAVLDYLYTKQL
S---PNLDLDPLELIALANR-FCLPHLVALAEQHAVQELTKAATS-GVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTN
YNSVCSKFRKEIKSK-SADNQ----EYFERHRWPPVWYLKEEDHYQRVKREREK----------------EDIALNKHRS
RRKWCFWNSSP------AVA------------------------------------------------------------
----------------
>Pan_troglodytes_RHOBTB1
--------------------------------------------------------------------------------
-----MDADMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKS
MWYPEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG
REVAKELGLP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMG
TNEAACLLDNPLCADVLFILQD-QEHIFAHRIYLATSSSKFYDLFLMEC---------------EESPNWSEGACE----
-KEKQSRDFQGRILS-VDPEEEREE----------------------------------------------GPPRIPQAD
QWKS----SNKSLV--EALGLEAEGAVPETQTLAGW-----------------------SKGFIGMHRE-MQVNPISKRV
GPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKD---LVGLAQIAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRK
ANRIKECLS-KGTFSDVTFKLDDGAISAHKPLLICSCE-WMAAMFGGSFVESANSEVY-LPNINKISMQAVLDYLYTKQL
S---PNLDLDPLELIALANR-FCLPHLVALAEQHAVQELTKAAMS-GVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTN
YNSVCSKFRKEIKSK-SADNQ----EYFERHRWPPVWYLKEEDHYQRVKREREK----------------EDIALNKHRS
RRKWCFWNSSP------AVA------------------------------------------------------------
----------------
>Mus_musculus_RHOBTB1
--------------------------------------------------------------------------------
-----MDSDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDEVSISLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKT
MWYQEIKH------------FCPRTPVVLVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG
REVAKELGIP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKVPECPSAG
TSDAACLLDNPLCADVLFVLHD-EEHIFAHRIYLATSSSKFYDLFLMEC---------------EESPCWGGGAG-----
-EEVPCRDFQGRTQS-LGSAEEGKE----------------------------------------------GPQRTPQAD
PGAS----SGQDLP--ESLALQMEASGSEGHALSGW-----------------------SKGFVSMHRE-VRVNPISKRV
GPVTVVRLDPSMQSGPFRTLLRFLYSGQLDEKEKD---LLGLAQMAEVLEMFDLRMMVENIMNKEAFMNQEITKAFHVRK
ANRIKECLS-KGTFSDVTFTLDDGAISAHKPLLICSCE-WMAAMFGGSFVESANREVH-LPNINKMSMQAVLEYLYTKQL
S---PNLDLDPLELIALANR-FCLTHLVALVEQHAVQELTKAAVS-GVSIDGEVLSYLELAQFHNANQLAAWCLHHICTN
YNSVCSKFRKEIKSK-SADNQ----EYFERHRWPPVWYLKEEDHYQRVKREREK----------------EDLALNKHHS
RRKWCFWHSSP------AVA------------------------------------------------------------
----------------
>Gallus_gallus_RHOBTB1
--------------------------------------------------------------------------------
-----MDIDMDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDEVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLNHVKT
MWYQEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLA----------RPIKRGDILPPEKG
REVAKELGIP-YYETSVFDQFGIKDVFDNAIRAALISRRH-LQFWKSHLKKVQKPLLQAPFLPPKAPPPVIKIPECPVPS
VNEAGYLLDSPLCADVMFVLQE-QDCIFAHKIYLATSSSKFYDLFLMEC---------------EESSDLGETQCN----
-KENTSKDVLTS--HLETNYDSDE------------------------------------------------ISLKSADV
KIPA----S-ESTDSLNMLKPEPAETISAARSLSSW-----------------------GKGFVSVHKE-MQVNPVSNRL
CPVTVVKMDSSVQAGPFKTVLQFLYTGQLDENEKD---LTRLAQIAEILEVFDLRMMVENIMNKEAFMNQEITKAFHVRK
ANRIKECLC-KGTFSDVTFKLDDGTINAHKPLLICSCE-WMSAMFGGSFIESLNSEVV-LPNINKTSMQAVLDYLYTKQL
S---STQELDILELIALANR-FCLPHLVALAEQHAVQELTKASMS-GIAIDGDVLSCLELAQFHNANQLAAWCLHYICTN
YNSVCSKFRKEIKAK-SSDNQ----EYFERHRWPPVWYLKEEDHYQRVKKEREK----------------EDFALNKHHS
RRKWCFWNSSA------VVA------------------------------------------------------------
----------------
>Danio_rerio_RHOBTB1
--------------------------------------------------------------------------------
---------MDYERPN-VETIKCVVVGDNAVGKTRLICARACNTTLTQ-----YQLLATHVPTVWAIDQYRVCQEV-LER
SRDVVDDVSVSLRLWDTFG----------------------------DHHKDRRFAYGRSDVVVLCFSIANPNSLHHVKT
MWYLEIKH------------FCPRTPVILVGCQLDLRYADLEAVNRA----RRPLS----------RPIKPGDILPPESG
REVAKELGIP-YYETSVFDQFGIKDIFDNAIRAALISRRH-LQFWKSHLRRVQKPLLQAPFLPPKAPPPLIKIPECPAKN
RDGPKQLLETPLCADVMFIVQE-HVHLYAHRIYLSTSSSKFFDLFQMDF---------------SDE---SQCLVV----
-TERHGRDQLMRTLS-LDTEEDVMV----------------------------------------------LPNLSPCSL
RASK----SDGTLK----MMSFSGMHRRTRLSLASW-----------------------SKAFYSIHKE-NVINPVTGTP
ALMTIVKMDHSIHHGPFSAVLRFLYTGELDEKEKD---LMKIAQIAEILEVFDLRMMVENIMNNEGFMNQEITKAFHVRK
ANRIKECLA-KNNFTDVVFRLDDGTINAHKPLLISSCD-WMAALFGGSFMESANDEVS-FPNTSRVCMQAVLEYLYTNQL
S---PMADLDPMELIALANR-LCLPRLIALTEQYAVSELLKASKD-GQDIDGEVLTYLELAQFHNANQLAAWCLHHICTH
YNRICANYRKEIKSK-SPENQ----EYFEKHRWPPVWYLKEEDHYQRVKKEREK----------------EDVVLNKHHS
RRRWCFWSTSP------AVA------------------------------------------------------------
----------------
>Caenorhabditis_elegans_RHOBTB1
--------------------------------------------------------------------------------
-------------MQA----IKCVVVGDGAVGKTCLLISYTTN-----------AFPGEYIPTVF--DNYSAN-------
--VMVDGRPINLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLVCFALNNPASFENVRA
KWYPEV------------SHHCPNTPIILVGTKADLREDRDTVERLRE---------------------RRLQPVSQTQG
YVMAKEIKAVKYLECSALTQRGLKQVFDEAIRAVLTPPQR-----------------AKK--------------------
--------------SKCTVL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_RHOU
-----------------MPPQQ--GDPAFPDR----------------CEAPPVPPRRERGGRGGRGPGEPGGRGR----
------------AGGAEGRGVKCVLVGDGAVGKTSLVVSYTTN-----------GYPTEYIPTAF--DNFS---AV----
--VSVDGRPVRLQLCDTAG--------------------------QDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNVSE
KWVPEI------------RCHCPKAPIILVGTQSDLREDVKVLIELDK---------------------CKEKPVPEEAA
KLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDT-----------------QQQ-------PKKSKSRTPD---
---KMKNLSKSWWKKYCCFV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Pan_troglodytes_RHOU
--------------------------------------------------------------------------------
---------------------------------------------------------------------------V----
--VSVDGRPVRLQLCDTAG--------------------------QDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNVSE
KWVPEI------------RCHCPKAPIILVGTQSDLREDVKVLIELDK---------------------CKEKPVPEEAA
KLCAEEIKAASYIECSALTQKNLKEVFDAAIVAGIQYSDT-----------------QQQ-------PKKSKSRTPD---
---KMKNLSKSWWKKYCCFV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_RHOU
-----------------MAPQQ--GRPALPARCEPP-------------AAPPVPPRRERGGRGARGPGVSGGRGR----
------------AGGAEGRGVKCVLVGDGAVGKTSLVVSYTTN-----------GYPTEYIPTAF--DNFS---AV----
--VSVDGRPVRLQLCDTAG--------------------------QDEFDKLRPLCYTNTDIFLLCFSVVSPTSFQNVGE
KWVPEI------------RRHCPKAPIILVGTQSDLREDVKVLIELDK---------------------CKEKPVPEEAA
KLCAEEVKAVSYIECSALTQKNLKEVFDAAIVAGIQHSDS-----------------QLQ-------PKKSKSRTPD---
---KVRDLSKSWWRKYCCLA------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Danio_rerio_RHOU_a
-----------------MPPQGGGGEYKPVPG----------------TVVPPVPPRRLRSRDLSSAVKSR---------
------------FGTAAERRVKCVLVGDGAVGKTSLIVSYTTN-----------GYPTEYVPTAF--DNFA---AV----
--VAVDGKPVKLQLCDTAG--------------------------QDEFDKLRPLCYTNADVFLLCFSVVSPSSFQNVRE
KWVPEI------------RRHCPRAPILLVGTQSDLREDVKVLIQLAQ---------------------YKERPVEPQDA
SVCAEEVQAVSYMECSALTQKNLKEVFDTAIVASIQYSDS-----------------QQQ--------KRLKKRTPD---
---KMRKLSESWWKKYCCLA------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_RHOQ
--------------------------------------------------------------------------------
----------MAHG-PGALMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS-------
--VTVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKE
EWVPEL------------KEYAPNVPFLLIGTQIDLRDDPKTLARLND---------------------MKEKPICVEQG
QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKK-------------------HTV-------------------
-----KKRIGSRCINCCLIT------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_RHOQ
--------------------------------------------------------------------------------
----------MAHG-PGALMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS-------
--VTVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKE
EWVPEL------------KEYAPNVPFLLIGTQIDLRDDPKTLARLND---------------------MKEKPVCVEQG
QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKK-------------------HTV-------------------
-----KKRIGSRCINCCLIT------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gallus_gallus_RHOQ
--------------------------------------------------------------------------------
---------------------------------------YAND-----------AFPEEYVPTVF--DHYAVS-------
--VTVEGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKE
EWVPEL------------KEYAPNVPFLLVGTQIDLRDDPKTLARLND---------------------MKEKPLSVEQG
QKLAKEIGAYCYVECSALTQKGLKTVFDEAIIAILTPKK-------------------HTV-------------------
-----KKRIGSRCINCCLIT------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Danio_rerio_RHOQ
--------------------------------------------------------------------------------
----------MANG-TGSIMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS-------
--VTVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVRE
EWVPEL------------QEYAPNIPYLLIGTQIDLRDDPKTIAKLND---------------------VKEKPIVTEQG
QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILAPKK-------------------GAL-------------------
-----KRRLGPRCINCCLIT------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_RHOQ_a
--------------------------------------------------------------------------------
-EDGAGQVGIMANG-TGTIMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVS-------
--VNVGGKQYLLGLYDTAG--------------------------QEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVRE
EWVPEL------------QEYAPSVPYLLIGTQIDLRDDPKTIAKLND---------------------MKEKPIVTEQG
QKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILAPKKK-----------------KGAL-------------------
-----KRRLGPRCINCCLIT------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_RHOG
--------------------------------------------------------------------------------
-------------MQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ-------
--SAVDGRTVNLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRH
KWHPEV------------CHHCPDVPILLVGTKKDLRAQPDTLRRLKE---------------------QGQAPITPQQG
QALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLN-PTP-----------------IKR--------------------
-------------GRSCILL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Pan_troglodytes_RHOG
--------------------------------------------------------------------------------
-------------MQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ-------
--SAVDGRTVNLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRH
KWHPEV------------CHHCPDVPILLVGTKKDLRAQPDTLRRLKE---------------------QGQAPITPQQG
QALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLN-PTP-----------------IKP--------------------
-------------ARSCILL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_RHOG
--------------------------------------------------------------------------------
-------------MQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ-------
--SAVDGRTVNLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRH
KWHPEV------------CHHCPDVPILLVGTKKDLRAQPDTLRRLKE---------------------QGQAPITPQQG
QALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLN-PTP-----------------IKR--------------------
-------------GRSCILL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gallus_gallus_RHOG
--------------------------------------------------------------------------------
-----AAEADSAAMQS----IKCVVVGDGAVGKTCLLICYTTN-----------AFPKEYIPTVF--DNYSAQ-------
--NTVDGRTINLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSIASPPSYENVKH
KWYPEV------------CHHCPSVPVLLVGTKKDLRTNPDTMRRLKE---------------------QNQAPISTQQG
LSLCRQIRAVKYLECSALQQEGIKEVFTEAVRAVLN-PAP-----------------AKA--------------------
-------------KRPCVLL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Danio_rerio_RHOG_a
--------------------------------------------------------------------------------
-------------MQS----IKCVVVGDGAVGKTCLLISYTTG-----------AFPKEYIPTVF--DNYSSQ-------
--VSVDNRTVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSISSPPSYENIKH
KWHPEV------------THHCPSVPILLVGTKSDLRNDADVLKKLKE---------------------QNQAPITTQQG
QALARQIHAVKYRECSALSQDGIKDVFADAVRAYLS-PQP-----------------VAN--------------------
-------------KKPCILL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Danio_rerio_RHOG_b
--------------------------------------------------------------------------------
-------------MQT----IKCVVVGDGAVGKTCLLISYTTN-----------AFPDEYIPTVF--DNYSTQ-------
--TCVDGRAVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTHVFIICFSVASPSSHANVRH
KWHPEV------------CHHCPGVPVLLVGTKRDLRGDKETLEKLKE---------------------QGMSPTTPQQG
SALARSIGAVRYLECSALLQEGVREVFNEAVRAVLY-PNA-----------------KKH--------------------
-------------TKKCVLL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Takifugu_rubripes_RHOG_a
--------------------------------------------------------------------------------
-------------MQT----IKCVVVGDGAVGKTCLLISYTTN-----------AFPEEYIPTVF--DNYSAQ-------
--MSVDGRTVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSIGSPSSHANVRH
KWHPEV------------SHHCPNVPILLVGTKKDLRGDTETVKKLKE---------------------QGLAPTTHQQG
NALAKQIGAVKYMECSALLQDGVREVFAEAVRAVLY-PVA-----------------KKN--------------------
-------------PKKCVLL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Takifugu_rubripes_RHOG_b
--------------------------------------------------------------------------------
-------------MQS----VKCVVVGDGAVGKTCLLISYTTG-----------AFPKEYIPTVF--DNYSSQ-------
--VTVDSRIVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSISSPASYENVKH
KWHPEVRVQWHNFDNHQVSHHCPDVAILLVGTKSDLRNDPDTQKKLKE---------------------QNQSPVTHQQG
AALARQIQAVRYMECSALNQDGIKDVFAEAVRAFLN-PQP-----------------TVS--------------------
-------------KRHCILL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_RHOG_a
--------------------------------------------------------------------------------
-------------MQS----VKCVVVGDGAVGKTCLLISYTTG-----------AFPKEYIPTVF--DNYSSQ-------
--VTIDNRIVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFAISSPASYENVKH
KWHPEV------------SHHCPDVPILLVGTKSDLRSDPDTQKKLKE---------------------QNQTPVTHQQG
AALARQIQAVRYMECSALNQDGIKDVFSEAVRAFLN-PQP-----------------TVS--------------------
-------------KRHCVLL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Tetraodon_nigroviridis_RHOG_b
--------------------------------------------------------------------------------
-------------MQT----IKCVVVGDGAVGKTCLLISYTTN-----------AFPEEYIPTVF--DNYSAQ-------
--MSVDGRTVSLNLWDTAG--------------------------QEEYDRLRTLSYPQTNVFIICFSIGSPSSHANVRH
KWHPEV------------SHHCPNVPILLVGTKKDLRGDTETVKKLKE---------------------QGLAPTTHQQG
NALAKQIGAVKYMECSALLQDGVKEVFAEAVRAVLY-PVA-----------------KKN--------------------
-------------PKRCVLL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Branchiostoma_floridae_RHOG
--------------------------------------------------------------------------------
-------------MQA----IKCVVVGDGAVGKTCLLISYTTN-----------AFPGEYIPTVF--DNYSAN-------
--VMVDGKPINLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLICFSLISPASFENVRA
KWHPEV------------SHHCPNTPIILVGTKLDLRDDKETIDKLQE---------------------KRLAPITYPQG
LQMMKDIGAVKYLECSALTQKGLKTVFDEAIRAVLCPTKV-----------------PKK--------------------
-------------KKECIII------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Anopheles_gambiae_RHOG
--------------------------------------------------------------------------------
-------------MQA----IKCVVVGDGAVGKTCLLISYTTN-----------AFPGEYIPTVF--DNYSAN-------
--VMVDGKPINLGLWDTAG--------------------------QEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRA
KWYPEV------------RHHCPNIPIILVGTKLDLRDDKNTVDKLRD---------------------KKLSPITYPQG
LAMAKEIGAVKYLECSALTQKGLKTVFDEAIRAVLCPMIP-----------------PKK--------------------
-------------KPKCNIL------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_RHOJ
-------------------------------------------------------------------------------M
NCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT-------
--VTVGGKQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE
EWVPEL------------KDCMPHVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG
VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKK------------------KK---------------------
------KRCS-EGHSCCSII------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Pan_troglodytes_RHOJ
-------------------------------------------------------------------------------M
NCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT-------
--VTVGGKQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE
EWVPEL------------KDCMPHVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG
VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKK------------------KK---------------------
------KRCS-EGHSCCSII------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_RHOJ
-------------------------------------------------------------------------------M
SCRERTDSSCGCNGHEENRILKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT-------
--VTVGGKQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE
EWVPEL------------KDCMPHVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG
VKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKK------------------KK---------------------
------KGCL-GCHGCCAII------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gallus_gallus_RHOJ
-------------------------------------------------------------------------------M
SCKAEGDDCTDGSSNSTKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYVPTVF--DHYAVT-------
--VTVGGQQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE
EWVPEL------------KVCMPNVPYVLIGTQIDLRDDPKTLARLLY---------------------MKEKPLTYEHG
VKLAKEIGAQCYLECSALTQKGLKTVFDEAILTIFHPKK------------------KK---------------------
------KHCA-KCHRCCTIV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Danio_rerio_RHOJ
-------------------------------------------------------------------MPTLSSKSRQNAL
EAAEDGGSNSDPVNTTAKKMLKCVVVGDGAVGKTCLLMSYAND-----------AFPEEYIPTVF--DHYAVN-------
--VTVSGRQHLLGLYDTAG--------------------------QEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQE
EWVPEL------------RSCMPHVPYILIGTQIDLRDDPKTLARLLQ---------------------MKEKPLTYEQG
LKLAREIGAQCYLECSALTQKGLKTVFDEAILTIFSPKK------------------QK---------------------
------RGCA-ACRCCCALV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Homo_sapiens_RHOV
-----------------------------------------------------MPPRELSE-AEPPPLRAPTP-------
--------PPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCN-----------GYPARYRPTAL--DTFS---VQ----
--VLVDGAPVRIELWDTAG--------------------------QEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITE
KWLPEI------------RTHNPQAPVLLVGTQADLRDDVNVLIQLDQG--------------------GREGPVPQPQA
QGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKAR-----------------LEKK-------LNAKG-------
----VRTLSRCRWKKFFCFV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Pan_troglodytes_RHOV
-----------------------------------------------------MPPRELSE-AEPPPLRAPTP-------
--------PPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCN-----------GYPARYRPTAL--DTFS---VQ----
--VLVDGAPVRIELWDTAG--------------------------QEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITE
KWLPEI------------RTHNPQAPVLLVGTQADLRDDVNVLIQLDQG--------------------GREGPVPQPQA
QGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKAR-----------------LEKK-------LNAKG-------
----VRTLSRCRWKKFFCFV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Mus_musculus_RHOV
-----------------------------------------------------MPPRELSE-AEPPPLPASTP-------
--------PPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCN-----------GYPARYRPTAL--DTFS---VQ----
--VLVDGAPVRIELWDTAG--------------------------QEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITE
KWLPEI------------RTHNPQAPVLLVGTQADLRDDVNVLIQLDQG--------------------GREGPVPQPQA
QGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKAR-----------------LEKK-------LNAKG-------
----VRTLSRCRWKKFFCFV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Gallus_gallus_RHOV
-----------------------------------------------------MPPQELLD--YAPALRRH---------
---------SPPRGSGPELGIKCVLVGDGAVGKTSLVVSYTTN-----------GYPDEYQPTAL--DTFS---VQ----
--VLVDGAPVRIQLWDTAG--------------------------QEDFDCLRSLCYPDTDVFLVCFSVVNPSSFQNITE
KWIPEI------------RTHNPRAPVLLVGTQADLRDDVNVLISLDR---------------------YHVKPVPRPQA
EGLADKIRAEAYLECSALTQKNLKEVFDMAIVSGVEHKAR-----------------QEKK-------MTAKG-------
----IKTLSKCRWKKFFCFV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Xenopus_tropicalis_RHOV
-----------------------------------------------------MPPQVMLD--CSDQKRLSPQLSELLC-
--------KQNSRPNSQELGIKCVLVGDGAVGKTSLVISYTIN-----------GYPTEYQPTAL--DTFS---VQ----
--VLVDGAPVRIQLCDTAG--------------------------QEDFDHLRSLCYAETDVFLVCFSVVNPSSFQNVTE
KWIPEI------------RTHSPHTPIVLVGTQADLRDDVNVLINLSR---------------------SHVKPVSESQA
QAVAQKIRAQTYIECSALTQKNLKEVFDASILSAIKHKAR-----------------LEKK-------LTSKG-------
----VKRLSKCRWKKYFCFV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------
>Danio_rerio_RHOV
-----------------------------------------------------MPP-QMDYFYHESRVPSVCL-------
---------EQDEELLEP-AISCMLVGDGAVGKTSMIVSYTTN-----------GYPTDYKQTAF--DVFS---GQ----
--VQVDGTPVRIQLMDTAG--------------------------QEEFDEFRSLSYAHTDVFLLCFSVVNPTSFQNITK