>Homo_sapiens_PKD1
------------------------MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGL
RTLGPALRIPADATALDVSHNLLRA---LDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGL
AWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDN----SSGTVAAVSFSAAHEGLLQPEA
CSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLSLCSGPPPPPAPTCRGPTLLQHVFP-ASPGATLVGPHGPLASGQ
LAAFHIAAPLPVTATRWDFGDGSAEVDAAGPA----ASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPAALELVCP
SSVQSDESLD--LSIQNRGGSGLEAAYSIVALGEEPAR-----AVHPLCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQ
AWAGAALAMVDSPAVQRFLVSRVTR--SLDVWIGFSTVQGVE--VGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGP
TGWCNTDLCSAPHSYVCELQPGGPVQDAENLLVGAPSGDLQGPLT-PLAQQDGLSAP-HEPVEVMVFPGLRLSREAFLTT
AEFGTQELRRPAQLRLQVYRLLST----------AGTPENGSEPESRSPDNR-TQLAPACMPGGRWCPGANICLPLDASC
HPQACANGCT-------SGP-GLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPG--------
ALLHCSP---APGHPGPRAPYLSANASSWLPHLPAQLE--------------------------GTWA--CPACALRLLA
ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAP-RDGRLYVPTNG-SALVLQVDS
GANATATARWPGGSVSARFENVCPALVATFVPGCPWETND---------TLFSVVAL---PWLSEGEHVVDVVVENSASR
ANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVV-----EAGSDMVFRWTINDKQSLTFQNVVFNVIYQSAAVFKL
SLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPNAT------LALTAGVLVDSAVEVAFLWTFGDGEQ-ALHQF
QPPYNESFPVPDPSVAQVLVEHNVMHTYAA---PGEYLLTVLASNAFENLTQQVPVSVRASLPSVAVGVSDGVLVAGRPV
TFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASR---GTYHVRLEVNNTVSGAAAQA-DVRVFEELRGLSVDMS
LAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLS-GPEATVEHVYLRAQNCTVTVGAASPAGHLARSLHVLVFVLEVLRV
EPAACIPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVN---RAHYFTSICV
EPEVGNVTLQPERQFVQLGDEAWLVACAWP--PFPYRYTWDFGTEEAAPTRARGPEVTFIYRDPGSYLVTVTASNNISAA
NDSALVEVQEPVLVTSIKVNGSL--GLELQQPYLFSAVGRGRPASYLWDLGDGGWLEG-PEVTHAYNSTGDFTVRVAGWN
EVSRSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV
TAENEVGSAQDSIFVYVLQLIEGLQVVGGG-------------RYFPTNHTVQLQAVVRDGTNVSYSWTAWRDR-G--PA
LAGSGKGFSLTVLEAGTYHVQLRATNMLGSAWADCTMDFVEPVGWLMVAASPNPAAVNTSVTLSAELAGGSGVVYTWSLE
-EGLSWETSEPFTTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQVPVSGLSIRAS-EPGGSFVAAGSSVPFWGQLATGT
NVSWCWAVP-----GGS-SKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTAEEPIVGLVLWASSKVVAPGQLVHF
QILLAAGSAVTFRLQVGG--ANPEVLP-GPRFSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVLEAVSGLQVPNCCEPGI
ATGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQY
VALQSGP--CFTNRSAQFEAATSPSPRRVAYHWDFGDGSP-GQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVT
VQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPAR-------------VALP
GVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANVTVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLE
DGDQTPLSFHWACVASTQREAGG--------CALNFGP---RGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTV
LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLR
RGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVHALTTKVHFE-----C
TGWHDAEDAGAPLVYALLLRRCR--QGHCEEFCVYKGSLSSYGAVLPPGFRP----HFEVGLAVVVQDQLGAAVVALNRS
LAITLPEPNGSATG----LTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNE----YERALDVAAEPKHERQHRAQ
IRKNITETLVSLRVHTVD---DIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILN
ITGDLIHLASSDVRAP--------------------------QPSELGAESPSRMVASQAYNLTSALMRILMRSRVLNEE
PLTLAGEEIVAQGKRSDPRSLLCYGGAPGPG---CHFSIPEAFSGALA----------NLSDVVQLIFLVDS--NPFP-F
GYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSAN----SANSVVVQPQASVGAVVTLD
SSNPAAGLHLQLNYTLLDG-----HYLSEEPEPYLAVYLHSEPRPNEH-NCSASRRIRPESLQG---ADHRPYTFFISPG
SRDPAGSYHLNLSSHFR----W-----SALQVSVGLYTSLCQYFSEEDMVWRTEGLL-----------------------
----PLEETSP---------------------RQAVCLTRHLTAFGAS--LFVPPSHVRFVFPEPTADVNYIVMLTCAVC
LVTYMVMAAILHKLDQLDASR-GRAIPFCGQ----RGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-VDSRSGH
RHLDGDRA---FHRN-----------SLDIFRIATPHSLGSVWKIRVWHDNKGLSP----AWFLQHVIVRDLQTARS---
----------AFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPP---------
-----RSRFTRIQRATCCVLLICLFLGANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVG--------------------
---------------LVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPA-GQQVLDIDSCLDSSVLDSSFLTFSGLHAEQ
AFVGQMK---------SDLFLDDSKSLVCWPSGEGTLSWPDLLSDPSIVGSN----------------------------
----LRQLARGQAGHGLGPE-------EDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDT------------
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-----------------------------------------------------------------HMETDLLSSLSSTPG
EKTETLA--LQRLGELGPP------SPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVG
--ASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP
VS---------------------ARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDAS----
-CHGHAY--RLQSAIKQELHS----------RAFLAITRSEELWPWMAHVLLP-YVHGN----------QSSPE-----L
GPPRLRQVRLQEALYPDP-----------------PGPRVHTCSAAG-GFSTSDYDVGWE--------------------
---------SPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRY
SPAVGLHAAVTLRLEFPAAGRALAALSVRPFALRRLSAGLSLPLLTSVC---LLLFAVHFAVAEARTWHREG--------
-------------------------------------------------------------RWRVLRLGAWARWLLVALT
AATALVRLAQLGAADRQWTRFVRGRPRRFT---------------SFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVR
QWSVFGKTLCRALPELLGVT-----LGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLST------------
--LCPAESWHLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRH
KVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTS--SSQLDGLS-------------------------------
-VSLGRLGTRCEPEP--SRLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRRS------------------------
-------------------------------------------------------------------------SRAPAGS
SRGPSPGLRPALPSRLARASRGVDLATGPS---------------RTPLRAKNKVHPSST--------------------
------------------------------------------------------------------------------
>Gorilla_gorilla_PKD1
------------------------MPPAAPVRLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRVNCSGRGL
RTLGPALRIPADATALDVSHNLLRA---LDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSGNPFECDCGL
AWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGCGEEYVACLPDN----SSGTVAAVSFSAAHEGLLQPEA
CSAFCFSTGQGLAALSEQGWCLCGAAQPSSASFACLS-CSSPPPPPAPTCRGRTLLQHVFP-ASPGAALVGPHGPLASGR
LAAFHIAAPLPVTATRWDFGDGSPEVDAAGPA----ASHRYVLPGRYHVTAVLALGAGSALLGTDVQVEAAPATLELVCP
SSVQSDESLD--LSIRNRGGSGLEAAYSIVALGEEPAR-----AVHPLCPSDTEIFPGSGHCYRLVVEKAAWLQAQEQCR
AWAGAALAMVDSPAVQRFLVSRVTR--SLDVWIGFSTVQGVE--VGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGP
TGWCNTDLCSAPHSYVCELRPGGPVQDAENLLVGAPSGDLQGPLT-PLAQQDGLSAP-HEPVEVMVFPGLRLSREAFLTT
AEFGTQELRRPAQLRLQVYRLLST----------AGTPENGSEPESRSPDNR-TQLVPACMPGGCWCPGANICLPLDASC
HPQACANGCT-------SGP-GLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPS--------
ALLHCSP---APSHPGPQAPYLSANASSWLPHLPAQLE--------------------------GTWA--CPACALRLLA
ATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAP-HHGRLYVPTNG-SALVLQVDS
GANATATARWPGGSVSARFENACPALVATFVPGCPWETND---------TLFSAVAL---PWLSEGEHVMDVVVENSASR
ANLSLRVTAEEPICGLRATPSPEARVLQGVLVRYSPVV-----EAGSDMVFRWTINDKQSLTFQNVVFNVI-QSAAVFKL
SLTASNHVSNVTVNYNVTVERMNRMQGLRVSTVPAVLSPNAT------LALTAGVLVDSAVEVAFLWTFGDGEQ-ALHQF
QPPYNESFPVPDPSVAQVLVEHNVTHTYAA---PGEYILTVLASNAFENLTQQVPVSVRTSLPSVAVGVSDGVLVAGRPV
TFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPAANHTYASR---GTYHVRLEVNNTVSGAAAQA-DVRVFEELRGLSVDMS
LAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLS-GPEATVEHVYLRAQNCTVTVGAASPAGHLAQSLHVLVFVLEVLRI
EPAACIPTQPHARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPTVTHNFTRSGTFPLALVLSSRVN---RAHYFTSICV
EPEVGNVTLQPERQFVQLGDEARLVACAWP--PFPYRYTWDFGTEEAGPARAGGPEVTCIYRDPGSYLVTVTASNNISAA
NDSALVEVQEPVLVTSIKVNGSL--GLELQQPYLFSVVGRGRPASYVWDLGDGGRLEG-PEVTHAYNSTGDFTVRVAGWN
EVSHSEAWLNVTVKRRVRGLVVNASRTVVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV
TAENEVGSAQDSIFVYVLQLIEGLQVVGGG-------------RYFPTNHTVQLQAVVRDGTNISYSWTAWRDR-G--PA
LAGSGKGFSLTALEAGTYHVRLRATNMLGSAWADCTVDFVEPVGWLMVAASPNPAAVNTSVTLCAELAGGSGVVYTWSLE
-EGLSWETTEPFTTHSFPTPGLHLVTMTAGNPLGSANATMEVDVQVPVSGLSIRAS-EPGGSFVAAGSSVPFWGQLATGT
NVSWCWVVP-----GGS-SKRGPHVTMVFPDAGTFSIRLNASNAVSWVSATYNLTVEEPIVGLVLWASSKVVAPGQPVHF
QILLAAGSAVTFRLQVGG--ASPEVLP-GPRFSHSFPRVGDHVVSVQGKNHVSWAQAQVRIVVLEAVSGLQVPNCCESGI
ATGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDAVQY
VALRSGP--CFTNRSAQFEATTSPSPRRVAYHWDFGDGSP-GQDTDEPRAEHSYLRPGDYRVQVNASNLVSFFVAQATVT
VQVLACREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPAR-------------VALP
GVDVSRPQLVLPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAPERLVPIIEGGSYRVWSDTQDLVLDGSESYDPNLE
DGDQTPLSFHWACVASTQREAGG--------CALNFGP---RGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATNQTV
LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLR
RGVLRDGEGYTFTLSVLGRSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVHALTTKVHFE-----C
TGWYDAEDAGAPLVYALLLRRCR--QGHCEEFCVYKGSLSSYEAVLPPGFRP----HFEVGLAVVVQDQLGAAVVALNRS
LAITLPEPNGSATG----LTVWLHGLTASVLPGLLRQANPQHVIEYSLALVTVLNE----YEQALEVAAEPKHERQRRAQ
IRKNITETLVSLRVHTVD---DIQQIAAALAQCMT---------------------------------------------
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-RDPAGSYHLNLSSHFR----W-----SALEVSVGLYTSLCQYFSEEDVVWRTEALL-----------------------
----PLEETSP---------------------RQAVCLTRHLTAFGAS--LFVPRSHVRFVFPEPTVDVNYIVMLTCAVC
LVTYMVMAAIVHKLDQLDASR-GHAIPFCGQ----WGRFKYEILVKTGWGRGS---------------------------
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---------------------------------------------------------------------------SSTPG
EKTETVA--LQRLGELGPP------SPGLNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVG
--ASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP
VS---------------------ARVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDAS----
-CHGHAY--RLQSAIKQELHS----------RAFLAITRSEELWPWMAHVLLP-YVHGN----------QSSPE-----L
GPPRLRQVRLQEALYPDP-----------------PGPRVHTCSAAG-GFSTSDYDVGWG--------------------
---------SPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFVELTRY
SPAVGLHAAVTLRLEFPAAGRALAALSIRPFALRRLSAGLSLPLLTSVC---LLLFALHFAVAEARTWHREG--------
-------------------------------------------------------------RWRVLRLGAWARWLLVALT
AATALVRLAQLGAADRQWTRFVRGRPRRFT---------------SFDQVAQLSSAARGLAASLLFLLLVKAAQQLRFVR
QWSVFGKTLCRALPELLGVT-----LGLVVLGVAYAQLAVLLVSSCVDSLWSVAQALLVLCPGTGLST------------
--LCPAESWQLSPLLCVGLWALRLWGALRLGAVILRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRH
KVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTS--SSQLDGLS-------------------------------
-VSLGRLGTRCEPEP--SRLQAVFEALLTQFD-LNQATEDVYQLEQQLHSLQGRRS------------------------
-------------------------------------------------------------------------SRAPAGP
SRGPSPGLRPALPSRLVRASRGVDLATGPS---------------RTPLRAKNKVHPSST--------------------
------------------------------------------------------------------------------
>Callithrix_jacchus_PKD1
--------------------------------------------------------------------------------
----------------DVSHNLLQA---LDVGLLANLSALAELDISNNKISTLEEGLFANLFNLSEMSCGSFGGCHWVGP
QVPSIPSASQLVRVSSPGRLCCHRCSKAWGWPLLSIVLWDSGCGEEYVACLPDN----SSGTMEAVAFSPAHEGLLEPEA
CSAFCFSTGQHLAALSEQGQCLCGAASPN-ASSACLALCSSPLPPPAPACGGPTLLQHVFP-ASSGAALVGPHGPLASGQ
PAAFHIAAPLPITAAHWDFGDGSPKVDGAGPV----ALHRYVLPGHYRVTAVLALGAGSALLETNVQVEAVPATLELVCP
SLVQSDESLQ--LSVRNRGGSGLEATYSIVALDEEPTR-----VVHPLCPLDTEIFPGNGHCYRLVVEKAAWLQAQEQCR
AWAGAALAMVDSPAVQRFLVSQVTR--SLDVWIGFSAVQG----AGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGP
TGWCNTDLCSAPHSYVCELRPGGPVQDAENFLVGAPSGDLQGPLI-PLVQQDDLSAP-RQPVEVMVFPVLSLSQEAFLTT
AEFGTQELLQPAQLRLQVYRPLST----------AGTPENGSEPESGFRDNR-TQPAPECMPGGCWCPGANVCLPLDASC
HSQACANSCM-------SGP-GLPKAPYMLWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVSLQHDAGPG--------
AFLHCPL---ASSSPGLQAPYLSANASAWLPRLPAQLE--------------------------GARA--CPACALRLLV
ATEQFTVLLGLRPNPGLQLPGRYEVQAEVDNGVSRHSLSCSFNVVSPVAGLRVIAPAP-HDGRLYVPTNG-SALVLQLDS
GANATATARWAGGNVSARFEATCPALVATLVPSCPWETND---------TLFSVIAL---PWLSEGEHVLEVVAENSASR
ANLSLQVMAEEPICGLRAMPSPEARVLQGVLVRYSPVV-----DAGSDVVFRWTINDKQSLTFQNIVFNVIYQSSAVFKL
SLTASNHVSNVTVNYNVTVERMNRMQGLQVSTVPAVLSPDAS------LLLTAGVLVDSAVEVAFLWTFGDGEQ-ALGHF
QPPYDESFPVPDPSVAQVLVEHNVTHTYTA---PGEYILTVLASNAFENLTKQVPVSVRSVLPSVAVGMSDSVLVAGRPV
TFYPHPLPAPGGVLYIWDFGDGSPVLMQSQPATNHTYTSR---GTYRVRLEVNNTVSSAVAQA-DLRVFEELRGLSVDMS
LAVEQGAPVVVRAAVETGDNVTWTFDMGDGTVLS-GPEATVEHVYLQAQNCTVTVGAASPAGRLAQSLHVLVFVLEVLRI
EPATCIPTQPDARLKAYVTGDPAHYLFDWTFGDGSSNRTVQGCPEVTHNFTQSGTFPLALVLSSRVN---KAHYFTSICV
EPEVGNVTLRPEKQFLQLGVAARLVACVWP--PFPYHYAWDFGTEEATSARAAGPRVTFTYRDPGSYLVTVTVSNNVSAA
NDSALVEVQEPVVVTDIEVNGSL--VLELQQPYLFSAVGRGRPASYLWDLGDGGQLEG-PEVTHTYNSTGDFTVRVAGWN
EVSRSEAWLNVTVKRRVRGLVINASRTVVPLNGSVSFSTLLEAGSDVRYSWVLCDRCTPIPGGPTMSYTFRSVGTFNVIV
TAENEVGSAQDSIFIYVLQLIEGLQVVGGG-------------GYFPTNHTVQLQAVVRDGTNISYSWAAQREG-G--PA
LAGSGRAFSLTTLEASTYHVQLRATNMLGSAWADCTVVFVEPVGWLMVAASPNPAAINMSVTLSAELAGGSSVLYTWSLE
-EGLSWETPEPFTTHSFPMPGLHLVTVTAGNPLGSANATMEVAVQVPVSGLSIRAS-EPSGSFVAAGSSVPFWGQLATGT
DVSWCWAVP-----GGG-SKYGPHVTMVFPEAGAFSLRLNASNAISWVSTTHNLTVEEPVVGLVLWASSKVVAPGQLVHF
QILLAAGSAVTFRLQVGG--AGPEVLS-GPRFSRSFPHVGDHVVSVQGENHVSWAQAQVRIVVLEAVSGLQVPNCCEQGI
ATGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQDTIQY
VALRSSP--CFTNRSAQFEATTSPSPRRVAYHWDFGDGAP-GWDTDEPRAEHTYLRPGDYRVQVNASNLVSFFMAQATVT
VQVLACREPEVDVALPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRIAR-------------MALP
GVDVSRPQLVLPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAPERLVPIVEGGSYRVWSDTQDLVLDGSESYDPNLE
DGDQTPLSFHWACVASTQREAGG--------CALNFGP---RGSSMVTIPRERLTAGVEYTFSLTVWKAGRKEEATNQTV
LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGRCLNCSSGSKQGRWAARTFSNKTLVLDETTTSTGSAGMQLVLR
RGVLRDGEGYTFTLTVLGHSGEEEGCASIRLSPNRPPLGGSCRLFPLG--------------AVHALTTKVYFE-----C
SGWQDAEDSSAPLVYALLLRRCR--QGHCEEFCVYKGSLSSYGAVLPPGFRP----HFEVGLAVVVQDQLGAAVVALNRS
LAIVLPEPNSSAAG----LTAWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEAI--YEQAPDTAAEPEHERQRRAQ
IRKNITETLVSLRVHTVD---DIQQIAAALAQCMGPSRELVCRSCLKQTLHKLEAMMRILQAETTAGTVTPTAIGDSILN
ITGDLIHLASSDVQGP--------------------------QPSELGAEPPSRMVASRAYNLTSALMRILMRSRVLNEE
PLTLAGEEIVAQGKRSDPGSLLCYGSAPGPG---CHFSIPEAFSGALS----------NLSDVVQLIFLVDS--NPFP-F
GYISNYTVSTKVASMAFQTQAGTQIPIERLASERAITVKVPNNSDWAALGHHSP-------AHSVVVQPQTSVGAVVTLD
SSNPAAGLHLQLNYTLLDG-----RYLSEEPEPYLAVYLHSEPRPNQH-NCSASRKIRPESLEG---TDHRPYTFFIAPG
NGDPAGSYYLNLTSHFH----W-----SVLEVSVGLYTSLCQYFSEEDMAWRTEGLL-----------------------
----PLEETSP---------------------QQAVCLTRHLTAFGAS--LFVPPSRVHFMPPEPTVGVNYIVLLTCTVC
LVTYAVMAAILHKLDQLDASR-GRAIPFCGQ----RGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-VDSQSGH
RHLDGDRA---FHRN-----------SLDIFQIATLHSLGSVWKIRVWHDNKGLSP----AWFLQHVIVRDLQTARS---
----------AFFLVNDWLSVETEANGGLVEKEVLAASDMALWSFRRLLVAELQRGFFDKHIWLSIWDRPP---------
-----RSRFTRIQRATCCVLLICLFLGANAVCYGTVGDSAYSTGHVSRLSPLSVDTVAIG--------------------
---------------LVSSVVVYPIYLAVLFLFRMSRSKVAVGPSPTPA-GQQMLDIDSCLGSSVLDSSFLTFSGLHAEQ
AFAGQMK---------SDLFLDDSKSLVCWPSSEGTLSWPGRFSDPSIVGSN----------------------------
-----RQLARGRAGHGLGPE-------EDSLSLASPYSPAKS--------------------------------------
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>Mus_musculus_PKD1
------------------------MPLGAPALLALALGLGLWLGALAGDPGRGCGPCPLPCFCGPAPDAACRVNCSGRWL
QTLGPSLRIPADATALDLSHNLLQT---LDIGLLVNLSALVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECNCGL
AWLPRWAKEHQVHVVQSEATTCRGPIPLAGQPLLSIPLLDNACGEEYVACLPDN----SSGAVAAVPFYFAHEGPLETEA
CSAFCFSAGEGLAALSEQNQCLCGAGQASNSSAACSSWCSSISLSLNSACGGPTLLQHTFP-ASPGATLVGPHGPLASGQ
PADFHITSSLPISSTRWNFGDGSPEVDMASPA----ATHFYVLPGSYHMTVVLALGAGSALLETEVQVEATPTVLELVCP
SFVHSNESLE--LGIRHRGGSALEVTYSILALDKEPAQ-----VVHPLCPLDTEIFPGNGHCYRLVAEKAPWLQAQEQCR
TWAGAALAMVDSPAIQHFLVSKVTR--SLDVWIGFSSVEGTE---GLDPRGEAFSLESCQNWLPGEPHPATAEHCVRLGP
AGQCNTDLCSAPHSYVCELRPGGPVWDTENFVMGMSGGGLSGPLH-PLAQQETVQGP-LRPVEVMVFPGLSPSREAFLTA
AEFSTQKLEEPAQMRLQVYRPSGG----------AAAVPEG----SSEPDNR-TEPAPKCVPEELWCPGANVCIPFDASC
NSHVCINGSV-------SRL-GLSRASYTLWKEFFFSVPAGPPTQYLVTLHSQDVPMLPGDLIGLQHDAGPG--------
TLLQCPL---ASSCPG-QALYLSTNASDWMTNLPVHLE--------------------------EAWA--GPVCSLQLLL
VTERLTPLLGLGPNPGLQHPGHYEVRATVGNSVSRQNLSCSFSVVSPIAGLRVIHPIP-LDGHIYVPTNG-SVLVLQVDS
GANATATAQWFGGNISAPFEDACPPEVDFLKQDCTEEANG---------TLFSVLML---PRLKEGDHTVEIVAQNGASQ
ANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMV-----EAGSDVAFRWTIDDKQSLTFHNTVFNVIYQSAAIFKL
SLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPTVLPPNAT------LALTGGVLVDSAVEVAFLWNFGDGEQ-VLRQF
KPPYDESFQVPDPTVAQVLVEHNTTHIYTT---PGEYNLTVLVSNTYENLTQQVTVSVRTVLPNVAIGMSSNVLVAGQPI
TFSPYPLPSTDGVLYTWDFGDGSPVLIQSQPVLNHTYSMT---GAYRITLEVNNTVSSVTAHA-DIRVFQELHGLTVYLS
PSVEQGAPMVVSASVESGDNITWTFDMGDGTVFT-GPEATVQHVYLRAQNFTVTVEAANPAGHLSQSLHVQVFVLEVLHI
EPSTCIPTQPSAQLMAHVTGDPVHYLFDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVN---KAHYFTSICV
EPEIRNITLQPERQFVKLGDEARLVAYSWP--PFPYRYTWDFGTEDTTHTQTGGSEVKFIYREPGSYLVIVTVSNNISST
NDSAFVEVQEPVLVTGIRINGSH--VLELQQPYLLSAMGSGSPATYLWELGDGSQSEG-PEVTHIYSSTGDFTVRVSGWN
EVSRSEAQLNITVKQRVRGLTINASRTVVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV
TAENEVGSAQDSIFIYVLQFIEGLQVAGGDN--G---------CCFPTNYTLQLQAAVRDGTNISYSWTAQQEGSL--IT
LFGSGKCFSLTSLKASTYYVHLRATNMLGSAAANRTIDFVEPVESLILSASPNPAAVNMSLTLCAELAGGSGVVYTWYLE
-EGLSWKTSMPSTTHTFAAPGLHLVRVTAENQLGSVNATVEVAIQVPVGGLSIRTS-EPDSIFVAAGSTLPFWGQLAEGT
NVTWCWTLP-----GG--SKDSQYIAVRFSTAGSFSLQLNASNAVSWVSAMYNLTVEEPIVNLMLWASSKVVAPGQPVHF
EILLAAGSALTFRLQVGG--SVPEVLP-SPHFSHSFFRVGDHLVNVQAENHVSHAQAQVRILVLEAVVGLQVPNCCEPGM
ATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIHVRAFNELGGVNLTLMVEVQDIIQY
VTLQSGR--CFTNRSARFEAATSPSPRRVTYHWDFGDGTP-VQKTEEFWADHYYLRPGDYHVEVNATNLVSFFVAQATVT
VQVLACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEIYRTASCQRPGRMAQ-------------MVLP
GVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLE
DGDQTPLNFHWACVASTQSETGG--------CVLNFGP---RGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTV
LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGHCHNCSRGYKQGCWAARTFSNKTLVLNETTTSTGSTGMNLVVR
PGALRDGEGYIFTLTVLGHSGEEEGCASIRLSPNRPPLGGSCRLFPLD--------------SVRGLTTKVHFE-----C
TGWRDAEDGGAPLVYALLLKRCR--QSYCENFCIYKGSLSTYGAVLPPGFQP----LFVVSLAVVVQDQLGAAVVALNRS
LTIVLPEPSGNPAD----LVPWLHSLTASVLPGLLKQADPQHVIEYSLALITVLNEY----EQAPD-VSEPNVEQQLRAQ
MRKNITETLISLRVNTVD---DIQQITAALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILN
ITGDLIHLASLDMQGP--------------------------QPLELGVEPPSLMVASKAYNLSSALMRILMRSRVLNEE
PLTLAGEEIVALGKRSDPLSLLCYGKALGPS---CHFSIPEAFSGALS----------NLSDVVQLIFLVDS--NPFP-F
GYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQAAQSSHNP-------VGSTIVQPQTSVSAVVTAD
NSNPQAGLHLRITYTVLNE-----RYLSAEPEPYLAVYLHSVSQPNEY-NCSASRRISLEVLEG---ADHRLYTFFIAPG
TGTLDRSYYLNLTSHFH----W-----SALEVSVGLYTSLCQYFSEEMMMWRTEGIV-----------------------
----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVQFIFPEPSASINYIVLLTCVIC
LVTYVVMAMILRKLDQLDVSR-VRVIPFCGK----GGRFKYEILVKTGWSRGSGTTAHV--G-----IMLYG-EDNRSGH
RHLDGDRA---FHRN-----------SLDIFQIATPHSLGSVWKIRVWHDNKGLSP----AWFLQHIIVRDLQSARS---
----------TFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPP---------
-----RSRFTRVQRVTCCVLLLCLFLAANAVWYGVVRDTTYSMGPVSSLISPGVDTVAIG--------------------
---------------LVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPT-GQQALDVDSYLDPSVLDSSLLTLSGLTEA-
-FAGQVK---------NDLFLEDAKSLVCWPSSEGTLSWPDLLSDPSVVSST----------------------------
----LQRLTQGRPGCMLGSE-------EDGASLVSPSLPAKYLSASDEDLIHQVLADGANNLVPTQDT------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------LLETDLLTSLSSVPG
EKTETLI--LQTVGEERPA------SMGLSWEQSPVTRLSRTGLVEGFQKRLLPAWCAPLAHGLSLLLVAVAVAVSGWIG
--ASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP
VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHDMLKRLLVYMLFLLVTLLANYGDAS----
-CHGHAY--RLQSAIKQELDS----------QAFLAITRSDEFWPWMSHVFLP-YVHGN----------QSSPE-----L
GPPRLRQVRLQEAFCPDP-----------------SSSE-HMCSAAG-SLSTSDYGIGWQS-------------------
---------VVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRSRAVFVELTRY
SPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVC---LLLFALYFSMAEVQTWRKDG--------
-------------------------------------------------------------CACTARPDTWARCLLVILT
AATGLVRLAQLGIADRQWTHFVQDHPRHFT---------------SFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVR
QWSVFGKTLCRALPELMGAT-----LGLVLLGVAYAQMAILLISSGADTLYNMARAFLVLCPGARVPT------------
--LCPSESWYLSPLLCVGLWALRVWGALRLGAILLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH
KVRFEGMDPLPSRSSRGSKSSPVVLPPSSGSEASHPSTS--SSQPDGPS-------------------------------
-ASLSRSTLKLEPEP--SRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLQGHGH------------------------
-------------------------------------------------------------------------NGPPSSP
SPGCFPGSQPALPSRLSRASQGLDQTVGPN---------------RVSLWPNNKVHPSST--------------------
------------------------------------------------------------------------------
>Rattus_norvegicus_PKD1
------------------------MPPGAPARLALALGLGLWLGALAGDPGRGCGPCPLPCFCSPAPDAACRVNCSGRWL
QTLGPSLRIPADATALDLSHNLLQT---LDIRLLVNLSGLVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECNCGL
AWLPRWAKEQQVHVVQSEATTCRGPVPLAGRPLLSTPLLDNACGEEYVACLPDN----SSGAVAAVPFFFAHQGPLETAA
CSAFCFSAGEGLAALSEQNQCLCGAGQPSNTSAACSSWCSSILLSFNSACGGPTLLQHTFP-ASPGAALVGPHGPLASGQ
PADFHINSPLPISSTCWNFGDGSPEVDMAGPA----ATHSYVLPGGYHVTVVLTLGAGSALLETEVQVEVAPTVLELVCP
SFVHSDESLD--LGIRHRGGSALEVTYSILALDKEPAQ-----VVHPLCPSDTEIFPGNGHCYRLVAEKAPWLQAQEQCR
TWAGAALAMVDSPAIQHFLVSKVTR--SLDVWIGFSSVEGKE---GLDPQGEAFSLESCQNWLPGEPHPATEEHCVRLGP
AGQCNTDLCSAPHSYVCELRPGGPVGDADNFLLGVSGGGRSGPLQ-PLAQQGTLQGP-LQPVEVMVFPGLSPSQEAFLTA
AEFETQELEDPVQLRLQVYRHSR-----------EAVAPEG----SSELDNS-TEPAPKCVPEELWCPGANVCVPFDALC
NSHVCINGSA-------SRL-GLPRASYTLWKEFFFSVPAGPPTQYLVTLHGQDVPMLPGDLVALQHDAGPG--------
TFLHCPL---ASSCPG-QALYLSTNASDWMTNLPVHLE--------------------------EAWA--GPVCSLQLLL
VTEQLTPLLGLGSNPGLQHPGHYEVRATVGNSISRQNLSCSFSVVSPVAGLRVIHPIP-LDGHIYVPTNG-SILVLQVDS
GANATATAHWFGGNVSAPFEDACPPEVDFLKQDCTEEANG---------TLFSVLVL---PRLKEGDHTVEIVAQNGASQ
ANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMV-----EAGSDVAFRWTIDDKQSLTFHNTVFNVIYQTAAVFKL
SLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPAVLPPNAT------LALTGGVLVDSAVEVAFLWNFGDGEQ-VLRQF
KPPYDESFQVPDPTVAQVLVEHNTTHIYNT---PGEYNLTVTVSNTYENLTQQVPVSVRTVLPNVTIGMSSNVLLAGQPI
TFFPYPLPSADGVLYTWDFGDGSPVLIQSQPVLNHTYSMT---GTYRISLEVNNTVSSVAAHV-DICVFQELHGLTVYLN
QSVEQGAPMVVNASVESGDNITWTFDMGDGTVFT-GPEATVEHVYLRAQNFTVTVGATSPAGHLSQSLHVQVFVLEVLRI
EPSTCIPTQPSAQIMAHVTGDPAHYLFDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVN---KAHYFTSICV
EPEICNVTLQPERQVVKLGDEAWLVAYPWP--PFPYRYTWDFGTEDSIHTQTGGSEVTFIYREPGSYLVIVTVSNNISST
NDSAFVDVQEPVSVTGIRINGSH--VLELQQPYLFSAMGNGSPAAYLWELGDGSQHEG-PEVTHIYSSTGDFTVRVSGWN
EVSRSEAQLNITVKQRVRGLTINASRTVVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV
TAENEVGSAQDSIFIYVLQLIEGLQVVGGDG--G---------CCFPTNYTLQLQAAVRDGTNISYSWTAQQDG-G--PT
LISSGKSFSLTALKASTYYVHLRATNMLGSASANRTIDFVEPVESLILSASPNPAAVNTSLTLGAELAGGSGVVYTWYLE
-EGLSRETSMPSTTHTFAAPGLHLVRVTAENQLGSVNATIEVAVQAPVGGLSIRTS-EPDSIFVAAGSTVPFWGQLAEGT
NVTWCWTLP-----GG--SKYSQYIDVRFPAAGHFSLWLNASNAVSWVSAVYNLTVEEPIMNLVLWASSKVVAPGQPVHF
QILLAAGSAVTFRLQVGG--SIPEVLP-SLHFSHSFFRVGDHMVSVQAENHVSRAQAQVRILVLEAIVGLQVPNCCEPGM
ATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGILEIHVRAFNELGGVNLTLVVEVQDIIQY
VTLQSGR--CFTNRSARFEAATSPSPRRVTYHWDFGDGTP-VQETEESWTDHYYLHPGDYRVEVNATNLVSFFVAQATVT
VQVLACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEVYRTTSCQRPGRMTQ-------------MVLP
GVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLE
DGDQTPLNFHWACVASTQSETGG--------CVLNFGP---RGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTV
LIRSGRVPIVSLECVSCKAQA--VYEVSRSSYVYLEGHCHNCSSGSKQGRWAARTFSNKTLMLNENTTSTGSTGMHLVVR
PGALHDGEGYIFTLTVLGHSGEEEGCASIRLLPNRPPLGGSCRLFPLE--------------SVRGLTTKVHFE-----C
TGWRDAEDGGAPLVYALRLKRCH--QNYCEDFCIYKGSLSTYGAVLPPGFQP----LFVVSLTVVVEDQLGASVVALNRS
LTIVLPEPSGNPAD----LIPWLHSLTASVLPGLLRQADPQHVIEYSLALITVLNEY----EQAPDMVSEPNLEQQLRAQ
MRKNITETLISLRVNTVD---DIQQITAALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILN
ITGDLIHLASLDMQGP--------------------------QPLELGAEPPSLMVASKAYNLSSALMCILMRSRVLNEE
PLTLAGEEIVALGKRADPLSLLCYGKAWGPS---CHFSIPEAFSGALS----------DLSDVVQLILLVDS--NPFP-F
GYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQAAQSSHSP-------VGSTIVQPRASVSAVVTAD
NSNPQAGLHLRITYTVLNA-----RYLSEEREPYLAVYLHSVSQPNEY-NCSASRRISLEVLEG---ADHRPYTFFIAPG
TGTLGRSYYLNLTSHFH----W-----SALEVSVGLYTSLCQYFSEEAMMWRTEGIV-----------------------
----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVQFIFPEPSVSINYIVLLTCVIC
LVTYVIMAMILRKLDQLDVSR-VRVIPFCGK----GGRFKYEILVKTGWSRGSGTTAHV--G-----IMLYG-EDNRSGH
RHLDGDRA---FHRN-----------SLDIFQIATPQSLGSVWKIRVWHDNKGLSP----AWFLQHIIVRDLQSARS---
----------TFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPP---------
-----RSRFTRVQRVTCCVLLLCLFLAANAVWYGVVGDTTYSMGPVSSLMSPSVDTVAIG--------------------
---------------LVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPT-GQQALDVDSYLDPSVLDSSLLTLSGLTEA-
-FSGQVK---------NDLFLEDAKSLVCWPSSEGTLSWPDLLSDPSVMSST----------------------------
----LQRLAQGRPGCMLGSE-------EDGASLVSPSLPAKYLSASDEDLIHQVLADGANNPDPTQDA------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------LIERDLLTSLSSAPG
EKTETLI--LQTMGEKRPP------SMGLTWEQSPVTRLSRTGLVEGLRKRLLPTWCAPLAHGLSLLLVAVAVAVSGWIG
--ASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP
VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHDMLKSLLVYMLFLLVTLLANYGDAS----
-CHGHAY--RLQSAIKQELDS----------QAFLAITRSDEFWPWMSHVLLP-YVHGN----------QSSPE-----L
GPPRLRQVRLQEAFCPDP-----------------SSSE-HMCSATG-SLSTSDYGIGWQS-------------------
---------VVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRWVLMFVELTRY
SPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVC---LLLFALYFSVAEVHTWRREG--------
-------------------------------------------------------------CARTARPEAWARWLLVMLT
AATGLVRLAQLGIADRQWTRFVHDHPHHFT---------------SFDQVAQLGSVARGLAASLLFLLLVKAAQQLRFVR
QWSVFGKTLCRALPELMGAT-----LGLVLLGVAYAQMAILLISSGADTLYSMARAFLVLCPGARVPT------------
--LCPSESWYLSPLLCVGLWALRVWGALRLGAVLLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH
KVRFEGMDPLPSRSSRGSKSSPVVPPPSAGSEASHPSTS--SSQPDGLS-------------------------------
-AGLGRSALRLEPEP--SRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLRGHGH------------------------
-------------------------------------------------------------------------SGPPSSP
SPGGFPASQPALPSRLARASQGPDQTTGPS---------------RVSLWPNNKVHPSST--------------------
------------------------------------------------------------------------------
>Canis_familiaris_PKD1
--------------------------------------------------------------------------------
----------------DVSHNLLRA---LDVGLLANLSALTELDISNNKISTLEEGIFSNLFNLSEINLSGNPLECDCGL
AWLPRWAEEQQVHVVRPEAATCAGPGPLAGQPLLGVPLLDGGCGEEYIACLPDN----SSGAVALVAFSAAHEGPLTPEA
CGAFCFAAGNGLGAFSDQGWCLCGAAQPPNTSSACLPFCSGAPLALAPACGGPTLLQNIFP-ASPGAALVGPQGPLASGQ
PAAFHVTASLPVSSTRWDFGDGSPKVDIAGPA----TTHRYLLPGLYHVTVVLALGAGSAQVETQVHVEAAPASLELTCL
TSVRSDETLK--FGIRNRGGSDLEATYSIVAVGEEPAQAADPAVVHPLCPSDTVIFPGNGHCYRLVAEKAAWLQAQEQCR
AWAGAALAMVDSPAIQHFLVSQVTR--SLDVWIGFSAVEGAE--AGPVVQGAAFSLESCQNWLPGEPHPATAERCVRLGP
AGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGAPIGDLQGPLS-PLAQQEALSAP-QELIEVMVFPSLGLSREAFLTA
AEFGTQELRRPTQLRLQVFRPVGE----------AGAPGNSREPESGSRESR-TESVPECTPEGRWCPRASIHLPPDDPC
GPWACANGSM-------SGP-GLPGASCVLLREFLFSVPAGPPSQYSVTFRGQDGPLKPGDLIALQHDAGPG--------
ALLCCSP---ALGAPGAEAPYFSATSPAWLVHLPAQLE--------------------------AAPA--GPACALRLLV
ATERLTTLLGLRPNPGLRRPGRYEVRATVGNSVSTHNLSCSFDVLSPVAGLRVAHPIP-HDGRLYVPTNS-SVLVLQVDS
GTNATATARWPGGNASAPFEATCPATVAALVPSCTLEAND---------TLFAVLVL---PGLSEGEHAVEIMVENSAGH
ANLSLRVKAEEPICGLRAAPSPEARVLQGVLVRYSPVV-----EAGSDVVFRWTIDDKQSLTFPHVVFNVIYQSAAVFSS
RLTASNHVSNVTVNYNVTVERMHKMKGLRVSAVPPVLPPNTT------LELAAHVLVDSAVEVAFLWTFGDGDQ-VLGQF
KPPYNESW-VPDPTVAQVLVEHSVTHVYAV---PGEYNLTLLVSNAFENLTQQVPVSVRATLPAVAVAVGSHVLVAGQPV
TFSPHPLPSPGGILYTWDFGDGSPAVTQHQTEVSHTYASR---GIYRIHLEVNNTVSSVTAWT-SVRVFEELRGLSVSLS
PSVEQGAPVTVSATLESGDNVTWTFDMGDGTVLV-GPEAMVEHVYLRAQNHTVTVGVSSPAGYLALSLPVHVFVLEVLRI
EPAACIPVQPHTWFMAHVTGDPAHYIFDWTFGDGSSNTTIFGDPTVTHNFTRSGTFPLALVLSSHVN---KAHYFTSVCV
EPEVGNVTLWPERQFVRLGDEAHLVARAWP--PFPYRYTWDFGPEDAP--RVGGPEATFTYADPGSYLVTVAVSNNISAA
NDSALVEVEEPVELTGIGVNGSG--VLELQRPYLFSAVGRGHPATYLWELGDGGRLEG-PSIKHTYNSTGHFTVRVSAWN
EVSRGEAWLNITVQRRVQGLSVNASRTVVPLNGSVSFTTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV
TAENEVGSAQDSIFIYVLRHIEGLQVAGGGG--G---------CCFPTNCTLQLQAVVSDGTNISYSWSAQRDG-G--PA
LAGSGKAFSLTVLEAGTYHVQLRAANMLGTSWANRTVDFVEPVGALAAAASPNPAIVNSSVTLCAELAGGSGVTYTWSPE
-GGLSWETPEPSSTHVFPSPGLYLVRVTATNWLGSANVTIEVAVQVPVSGLSIRAG-DIDRGFVAAGSAVPFWGQLDSGT
NVSWCWTVP-----GG--SRRGQHVAVVFRDAGAFSVRLNASNAVSWVTATRELTVEEPIAGLVVWADSKVVEPGQLVHF
QVMLAAGSAVRFHLQVSG--AAVEALP-GPRFSRSFPRVGDYMVSVQAENHVSRAQAQVRILVLEAVGGLQVPHCCELGI
PTGTERNFTARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIHVRAFNDLGGVNLTLLMEVQDAIQH
VVLRSGR--CFTNRTARFEAATSPSPRRVAYRWDFGDGAV-VEDTEEPWAEHSYLRPGDYRIEVNASNLVSFFVAQATVT
VHVLACREPEVDVALPPQVLMRRSQRNYLEAHVNLRDCVTYQTEYRWQVYRAASCQRPGRLAP-------------VALP
SVDMSRPQLVVPRLALPVGHYCFVFMVSFGDTPLARSIQANVTVVPERLVPIVEGGSYRVWSDTQDLVLDGSKSYDPNLE
DGDQTPLSFHWACVASTQSETGG--------CTLTFGP---RGSSVVIVPRERLQAGVEYTFNLTVWKAGRKEEATNQTV
LIRRGRVPIVSLECVSCKAQS--VYAVSRKSYVY-EGRCDNCSEGSKRGRWAARTFSNQTLVLDETTTSTGSSGMRLVLR
RGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSANRPPRGGSCRLFPLD--------------AVRALTTKVHFE-----C
TGWQDAEDASAPLVYALLLRRCR--QGHCEEFCVYRGSLSAYGAVLPPGFAP----HFQVGLAVVVQDQLGAAVVALNRS
LAITLPQPPGDPQGGPTDLTSWLHGLTESMLPRLLRQADPQHVIEYSLALITVLNEASAGSEQVLAVVAEEDARRQLQAQ
IRKNVTETLVSLRVNTVD---DIQQIAAALAQCTVSSRELVCHSCLKKTLHKLEAMMRILQAETAAGTGTPTGIADSILN
ITGDLIHLASVDMQGL--------------------------QPSELGTEPPSLMVASRAYHLSSALMCILMRSRVLNEE
PLTLAGEEIVAQGKRSDPLSLLCQGNASVPS---CHFSIPTAFSGALS----------NLSDVVQLMFLVDS--NPFP-F
GYISNYTVSTKVASMAFQTQAGTQIPIGQLASERAIIVKVPNSSDQAAPGHRAP-------AGSAVIQPQASISVAVTPE
NSNPAAGLHLQLTYTLLNE-----RYLPEEPEPYLAVYFDSVPGPNEH-NCSASRRISLEELAG---GDHRPYTFFIAPG
TRDSGGTYYLNLTSHFH----W-----SALEVSVGLYTSLCQYFSEKEMMWKTEGLV-----------------------
----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVHFIFPEPASGVNYIVLLTCIVC
LVTYTVMAVILRKLDQLDVSR-VRIIPFCGK----GGLFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-AEGRSGH
RHLDGDRA---FRRN-----------SLDVFQIATPHSLGSVRKIRVWHDNKGLSP----AWFLQHIIVRDLQNARS---
----------TFFLVNDWLSVETEANGGLVEKEVLAASEAALRRSRRLLVAELQRGFFDKHIWLSIWDRPP---------
-----RSRFTRVQRATCCILLVCLFLGANAVWYGVVGDTASSAGPVSTLIPLSVDTIAVG--------------------
---------------LVSSVVVYPVYLVILFLFRMSRSKVAGAPSPTPA-GQQVLDVDSYLDSSVLDSSFLTFPGLRTE-
AFAGQMK---------SDLFLDDSKSLVCWPSSEGTLNWPDLLSDPSIMGST----------------------------
----LQRLARGRTGHTLGPE-------DDGLSLLSPSSPAKYFSASDEDLIQQILAEGASSLAPTQDT------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------QVETDLLTSLSSAPG
ETTETLT--LQRLGERGPPC-----SSGVTWEQPTSARLSGTGLADGLQKRLLPAWCASLAHGLSLLLAAVAVGVSGWVG
--SSFPPGVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP
VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLANHGDAS----
-CHNHAY--RLQSAIKQELGS----------QAFLAITRSDEFWPWMSHVLLP-YIHGN----------QSGPE-----L
GPPRLRQVRLQEALCPDP-----------------PGAAVHACSAGQDAFSTGDYSIGWGS-------------------
---------AAQNCSETWAYSAPDLLGIWSWGYCAVYDSGGYVQELGLSLEESRAQLGFLQLHNWIDNRSRAVFVELTRY
SPAVGLHAAVTLRLEFPAAGHAVTAVSVRPFPLQRLSTGLSLPLLTSV---SLLLFALYFSVAEVRTWRREG--------
-------------------------------------------------------------CRRAAQPGAWARWLLVALT
AAAALVRLAQLGVADRQWARFLRRRPRRFT---------------SFEQVAQLSAAARGLAASLLFLLLVKAAQQLRFVR
QWSVFGKTLCRALPELVGAA-----LGLVALAVAYAHLAVLLVSSCVDSFRSAARALLVLCPGSGGPA------------
--LCPAESWRLSPLLCTGLWALRLWGALRLGAVLLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH
KVRFEGMEPLPSRSSRGSKSSPDAPPPSGGSDTSRPSTS--SSQLDTLS-------------------------------
-GGLGRLGPRGEPEP--SRLQAVFEALLTQFDRLNQATEDVYQLEQRLQSLRGRRS------------------------
-------------------------------------------------------------------------TVPPASP
PHSPCSALQPALPSRLARASRGMGLASGPS---------------RASLRAKNKVHPSST--------------------
------------------------------------------------------------------------------
>Felis_catus_PKD1
--------------------------------------------------------------------------------
----------------DVSHNLLRA---LDAGLLANLSALTELDISNNKISTLEEGLFANLFNLSEINLSGNPLECDCGL
AWLPRWVEEQQVRVVRPEAATCAGPGPLAGRPLLGVPLSDSGCGEEYIACLPDN----SSGAVVPVAX------------
-------AGWGLGALSDQGWCLCGAAQPPNASSACLPLCSSPPLPLAPACGGPTLLENVFP-ASPGAALVGPPGPLASGQ
PAAFHVTASLPVSSTHWDFGDGSPKVDVAGPA----TTHRYSLPGHYQVTAVLALGAGSAQLGAKVQVEAAPAALELECP
VSVLSDETLK--LGVRNRGGSGLEATYSIVSLGEEPGR-----VVHPLCPSDTVIFPGNGHCYRLVAEKAAWLQAQEQCQ
AWAGAALAMVDSPAVQRFLVSQVTR--SLDVWIGFSAVEGAE--AGPAVRGEAFSLESCQNWLPGEPHPATAERCVRLGP
AGQCNTDLCSVPHSYVCELRPGGPVWDAENFLVGAPPGDLQGPLS-PLAQQEALSAP-QEPVEVMVFPSLGLSREAFLIA
AEFGTQELHRPAQLRLQVFRPEGG----------AGAPGHGGEPESASLESQ-ARPVPACTPEGRWCPQTGIPLSPDTLC
RPRACANTST-------SGP-GPPGTSCVLWKEFLFSVPAGPPTHYSVPFQGQDGPLLPGDLVTLQHDAGPG--------
ALLHCSP---ALGPPGPEAPYLSAVASAWLAHLPAQLE--------------------------VAPT--GPACALRLLA
ATERLTPLLGLRPNPGLRRPGHYEVRATVGNSVSMHNLSCDFDVLSPVAGLRVAHPTP-HDGRLYVPTNG-SVLVLRVDS
GTNATATAHWPGGNVSAPFEAAX-------------------------------------------------VVENSAGQ
ANLSLQVKAEEPICGLRATPSPEARVLQGVLVRYSPMV-----EAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFKL
SLTASNHVSNVTVNYNVTVERMNRMRGLWVSAVPPVLPPNAT------LALAAHVLVDSAVEVAFLWTFGDGDQ-VIGQF
KPPYSESFRVPDPAVAQVLVEHNVTHAYAI---PGEYNLTLLVSNAFENLTRQVSVSVRATLPAVAVAVGSRVLVAGQSV
TFAPRPLPSPGGILYTWDFGDGSPAVTQHRPEVNHTYSSG---GEYRVRLEVNNTVSSVTACV-GIRVFEELRGLSVSLS
PSVEQGAPVTVSATLESGDNVTWTFDMGDGTVLT-GPEATVEHVYLRARNCTVTVGASSPAGRLALSLPLQVFVLEVLRI
EPAACIPVQPLARLTAHVTGDPTHYIFDWTFGDGSSNTTVSGDPTVTHNFTRSGTFPLTLVLSSHVN---KAHYFTSVCV
EPELGNVTLWPERQFVRLGDEARWVARAWP--PFLYRYTWDFGTEDPA--RVGGPEATFAYPASGSYLVTVAVSNNISAA
NDSALVEVQEPVELTGVRVNGSR--VLELQQPYLFSAVGRGCPATYLWELGDGGLLEG-SAVTHAYNSTGHFTIRVTGWN
EVSRGEARLNVTVRERARGLSVNASRTVVPLNGSVSFTTSLEAGSDVRYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV
TAENEVGAAQDSIFVYVLQHIEGLQVVGGGG--G---------CCFPTNRTLQLQAVVRDGTNISYSWTAQRDG-G--PA
LAGSGRAFSLTVLEAGTYHIQLRAANMLGSALANRTVDFVEPVGWLAAAASPNPAAVDASVTLCAKLAGGSGVIYSWSLE
-GGLSWETPEPSTTHTFPTPGLYLVTVTARNQLGSANATTEVAVQVPVSGLSIRAG-ELGGSFVAAGSAVPFWGQLDSGT
DVSWCWEVP-----GG--SRHGQHVSVVFRDAGAFSVRLNASNAVSWGLATRELTVEEPVAGLVLWASSKVVAPGQPVHL
QVLLAAGSAVSFYLQVGG--AAPEALP-GPRFSRSFPRAGDYTLSVQAENHVSRAQAQVRILVLEAVGGLQVP-------
-------------------------------------------------AGLLEIHVRAFNELGGVNRTLVVEVQDTIQH
VVLRSGR--CFTNRSARFEAATSPSPRRVAYRWDFGDGAP-AEDTEEPWAEHSYLRPGDYRVEVNASNLVSFFVAQATVT
VHVLACREPEVDVALPPQVLMRRSQRNYLEAHVNLRDCVTYQTEYRWEVYRAAGCHRPVRMAP-------------VALP
SVDMSRPQLVVPRLALPVGHYCFVFLVSFGDTPLARSIQANVTVVPERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLE
DGDQTPLSFHWACVASTQSETGG--------CTLAFGP---RGSSVVTVPRERLQAGVEYTFNLTVWKAGRKEEATNQTV
LIRRGRVPLVSLECVSCKAQA--VYAVSRSSYVYLEGRCDNCSGGSQRGRWAARTFSNETLVLDETTTSTGSSGMRLVVR
RGVLRDGEGYTFTLTVLGRSGEEEGCASIRLSANRPPRGGSCRLFPLD--------------AVRALTTKVHFE-----C
TGWQDAEDAGAPLVYALLLRRCR--QGHCEEFCVYRGSLSAYGAVLPPGFAP----HFQVDLAVVVQDQLGAAVVALNRS
LAITLPELPSDLPGGPLDLTTWLHSLTESMLPRLLRQADPQHVIEYSLALITVLNEH----EQALASSAESDPRRQLQAQ
IRKNVTEILVSLRVNTVD---DIRQIAAALAQCTVSSRELVCRSCLKKTLHKLEGMMHILQAETAEGTGTPTAIADSILN
ITGDLIHLASADVQGP--------------------------QPSELGAEPPSLMVASRAYHLSSALMCILMRSRVLNEE
PLTLAGEEIVAQGKRSDPLSLLCQGDASVPG---CHFSIPEAFSGALS----------NLSDVVQLIILVDS--NPFP-F
GYISNYTVSTKVASMAFQTQAGAQIPIGRLASERAITVKVPNNSDQAARGCRTP-------AGSAVVQPQASVGVVVVPE
DNNPDAGLHLQLTYSVLSE-----HYLSREPEPYLAVYLHSVPQPNEH-NCSASRRIGPEALAG---RDHRPYTFFIAPG
SRDPGGTYYLNLTSHFR----W-----SALEVTVGLYTSLCQYFSEKDMMWRTEGLV-----------------------
----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSHVRFIFPEPASGVNYVVLLTCSVC
LVTYVVMAVILRKLDQLDVSR-VRVIPFCGK----GGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-AEGRSGH
RHLDGDRA---FRRN-----------SLDVFQIATPHSLGSVRKIRVWHDNKGLSP----AWFLQHIIVRDLQTACS---
----------TFFLVNDWLSVETEANGGLVEKEVLAASDAAVRRFRRLLVAELQRGFFDKHLWLSLWDRPP---------
-----RSRFTRVQRATCCVLLVCLFLGANAVWYGVVGDAAYSAGPVSGLIPLSADTVAVG--------------------
---------------LVSSVVVYPVYLVILFLFRMSRSKVAGGPSPTPA-GQPVLDIDSYLDSSVLDSSFLAFPGLRAE-
AFAGQMK---------SDLFLDDCKSLVCWPSSEGTLNWPDLLSDPSIVGST----------------------------
----LQRLARGR----LGPE-------EDGLSLVSPSSPAKSFSASDEDLIRRIVAEGAGSLAPARDA------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------QIETDLIAGLSSAPA
ERTETLM--LQRLGDRGLP------SPGLTWERPQSAKPARTGLVDGLRRRLLPAWCAPLAHGLSLLLVAVAVGVSGWVG
--ASFSPGVGVMWLLSSSSSFLASFFGWEPLKVLLEALYFSL----------------VAKRLHPDEDDTLVESP-AVTP
VS---------------------ERVPRVRPPHGFALFLAKEEARKVKKLHGMLRSFLVYMLFLLVTLLANHGDAS----
-CHSHAY--RLQSAIKQELGS----------QAFLAITRSEEFWPWMSHVLLP-YIHGN----------QSSPE-----L
GPPRLRQVRLQEALCPDP-----------------ARPGVPVCAAAAGSFSTGDYGIGWGS-------------------
---------AAHNGSEMWAYSAPDLLGVWSWGYCAVYDSGGYVQELGLSLEESRAQLGFLQLHNWIDNRSRAVFVELTRY
SPAVGLHAAVTLRLEFPVAGHAVTAVSVRPFALRRLN-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------RALPELVGAA-----LGLVVLAVAYAQLAILLVASCVDSFRSALRAVLVPCPGSGGPA------------
--PCPAESWRLSPLLCTGLWALRLWGALRLGAVLLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH
KVRFEGMEPLPSRSSRGSKSSPDAPPPSGGSDASRPSTA--SSQLDTP--------------------------------
-GGAEPAGPRGEPEP--SRLQAVFEALLTQFDRLNQATEDVYQLEQRLQSLQGRRS------------------------
-------------------------------------------------------------------------TG-----
AHSPSSDLRPALPGRLARASRGVGLAPGPC---------------RVSLRAKNKVHPGST--------------------
------------------------------------------------------------------------------
>Bos_taurus_PKD1
------------------------MPPAAPARLALALGLGLWLGALAGVPGRGCGPCAPPCLCGPAPGAACLVNCSGQGL
RTLGPALRIPADATALDVSHNLLQA---LDIGLLANLSALMELDISNNKISTLEEGIFANLFNLSEVNLGGNPLECDCGL
AWLPRWVEGQRVRVVRPEAATCAGPGPLAGQPLLGGALLDGACGEEYVACVPDD----SSGAVALVAFLAAPEGPLAPEA
CSALCFEAGQALAALSEQGRCLCGAARPPNASSACLPSCSGPSLPLAPACRGPSLLQHVFP-ASPGATLLGPQGPLASGQ
PAVFHVTALLPVSSTHWDFGDGSPEVDVTGPD----ATHRYVLPGRYPVTAVLALGVGSARLGVEVRVEAAPAALELVCV
ASVHSEETLQ--LSVRNRGGSGLEAAYSIVALGEEPAQ-----VVHPLCPSDTEIFPGNGHCYSLRAEKASWAQAQEQCR
AWAGAALAMVDSPAVQHFLVSRVTR--SLDVWIGFSAVEGAA--AGPAPQGGAFSLESCQNWLPGEPHPATAERCVRLGP
AGQCNTDLCSAPHSYVCELRPGGPVWDAENFLVGAPNGDLQGPLS-PLEQQEALLAP-QEPVEVMAFPGLSPSREAFLTA
AEFGTQELGRPAQLRLQVYRAGRG----------AGAPGNSSEPQGRSLENR-TELAPVCAPEGPLCPQANVCLPLDTPC
HPGACANGSM-------PGP-GLPGVSYVLQKEFLFSVPAGPPAQYSVPFHGQDIALLPGDLVILQHDAGPG--------
TLLRCPP---ALSFPGSEAPYFSANASAWLAHLPAQLE--------------------------AAPA--GPACALRLLA
ATERLTPLLGLGPNPGLRRPGRYEVRATVGNSVSRHNLTCIFDVLSPVAGLRAIYPAP-QDGRLYVPTSG-SPLVLQVDS
GANATAEARWPGGNASAPFEAACPAAVAALAPGCAQEANG---------SLFSMLTL---PGLREGEHEVEVVVENGAGR
ANLSLLVTAEEPIRGLRATPSPEARVLQGVLVRYSPAV-----EAGSDVVFRWTIDDKQSLTFHNVVFNVIYQSAAVFKL
SLTASNHVSSVSAHFNVTVEPMQRMRGLCVSAVPPVLAPNAT------LALAAHVLVDSAVEVAFLWTFGDGQQ-AVGQF
KPPY-DSFEVPDPTVAQVLVEHNTSHTYTF---PGEYSLSLLVSTAFENLTQQVPVSVRAALPAVAVAVGSQVLVAGRPV
AFFPRPLPSPGGVLYTWDFGDGSPAVTQPQPEVNHTFALR---GTYRVRLEVNNTVSHTVADV-SVRVFEELCGLTVSLS
PAVEQGVPTVVSAALDSGDNVTWTFDMGDGTVLT-GPEATVEHVYRRAQNCTVTVSASSPAGHLARSLPVHVFVLEVLWI
EPVACIASQPHARLTAHVTGDPAHYVFDWTFGDGSPNVSIQGDPTVTHSFTHSGTFPLALVLSSRVN---RAHYFSSVCV
EPELGNVTLQPERQFVRLGDEARLVAHAWP--PFPYRYTWDFGAEDGAT-HVGGPEATFTYQLAGSYLVTVTAANNISAT
NDSALVEVQEPMEVTGIRVNSSH--ALELQQPYLFSAVGRGHPASYLWELGDGRQLQG-PTVTHAYSSTGCFQVRVAGWN
EVSRGEARLNVTVQRRVRGLSLNASRTVVPLNGSVSFSTVLEAGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIV
TAENEVGAAQDSIFVYVLQHIEGLQVVGGG-------------CCFPTNRTLQLQAVVRDGTNISYSWAAQRDG-G--PT
LAGSGKAFSLTVLEAGTYHVQLRATNMLGSASANCTVDFVEPVGWLAVTASPNPAAVNTSVTLWAELAGGSSVIYSWSLE
-EGLCWETREPSTTLIFPSPGLCLVTVVAKNQLGSANASVEVVVQVPVGGLSIQAR-ELDGGFVVAGSTVPFWGQLAVGT
DVSWRWAVP-----GG--SRQGQHITVVLPDAGPVSIQLNASNAVSWVTATHNLTVQEPIVGLVLWASRKVVEPGQPVHF
QILLAAGSAVRFLLQVGG--GGLEVLP-TPHFSRSFPRVGDYTVSVHAENRVSRAQAQVRISVLEAVGGLQVPDCCGPAI
ATGAERNFSARVQRGSRVAYAWYFSLQKVQGDS-LVILSGRDVTYTPVAAGLLEIHVRAFNELGGVNCTLLVEVQDAIQH
VVLRGPR--CFANRSAHFEAATSPSPRRVSYHWDFGDGAP-VEDTEGPWAVHSYLQPGDYPVQVNASNLVSFFVAQATVT
VHVLACREPAVDVALPPQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRATSCQRPGRAAR-------------VALP
GVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAPERLVPIVEGGSSRVWSDSQDLVLDGSKSYDPNLE
DGDQTPLSFHWACVAATQSETGG--------CALNFGP---RGSSVVTIPRERLRAGVEYTFNLTVWKAGRKEEVTSQTV
LVRSGRVPIVSLECVSCKAQA--VYAVSRSSYVYLEGRCDNCDGGLEHGLWAARSFSNETLVLDATTTSTGSTGMRLVVR
RGVLRDGEGYTFTLTVLGRSGQEQGCASIRLAPNRPPRGGSCRLFPVE--------------DVRALTTKLHFE-----C
TGWQDAEDAGAPLVYALQLRRCR--QGHCEEFCVYKGSLASYGAVLPPGFAP----HFVVGLAVLVQDQLGAAVVALNRS
LTITLPDPPGDPADGPLDLMGWLHSLAGSTLPGLLRQADPQHVMEYSLALIAVLNEY----EQTLPVLAEPDPRQELRAQ
IRKNITETLVSLRVNTVD---DIQQVAAALAQCTVSSRELVCRSCLKKTLHRLEDMMRILQAETATGAGTPTTIADSILN
ITGDLIHVASSDVQGP--------------------------QPSELGAEPPSLLVASRAYQLSSALVGILTRSRVLNEE
PLTLAGEEILAQGKRSDPRSLLCQGDVPGPG---CHFSIPEAFSAALP----------NLSDVVQLILLVDS--NPFP-F
GYISNYTVSTKVASMAFQTQAGAQIPIRQLASERAITVKVPNNSDQAAQDQYVP-------AGSTVIQPRASVSVVVTPE
NSNPEAGLHLQLTFTVLDE-----QYLPDEPEPFLAAYLHSEPRPNEY-NCSASKKISLEALAG---GDHRPYTFFIAPG
SRDLGASYHLNLSSHFR----W-----SALAVSVGLYTSLCQYFSEEHMAWRSEGLV-----------------------
----PLEETSP---------------------REAVCLTRHLTAFGAS--LFVPASRIEFTFPEPASGINHVVLLTCAVC
LLTYAVMAVILRKLDQLDVRR-VRAIPFCGK----GGRFKYEILVKTGWGRGSGTTAHV--G-----IMLYG-ADGRSGH
RHLDGDGA---FQRN-----------SLDVFQIATPHSLGRLWKIRVWHDNKGLSP----AWFLQHVIVRDLQSARS---
----------TFFLVNDWLSVEMEANGGLVEKEVLAASDAVLWRFQRLLVAELQRGFFDKHVWLSMWDRPP---------
-----RSRFTRVQRATCCVLLVGLFLGANAVWYGAVGDSAHSQGPVSSLAPLSLDTVAVG--------------------
---------------LVSSLVVYPVYLAILFLFRMSRSKVAGGPSPTPA-GPQALDVDSCLDSSMLDSSMLAFPGLGGE-
AFAGQMK---------QDLFLEDSKSLVCWPSSEGTLSWPDLLSDPSVMGSA----------------------------
----LQRLARGRMGLTPGPE-------EDSLSLVSPSSPAKYFSASDENLIRQILAEGAGSLAPTQDT------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------QGETDLLAGLCSAPG
EKTQPAM--LRSLGDTRLP------SPGLTWEQPPPARLPRTGLVEGLRKRLLPAWCAPLAHGLSLLLVAVAMGVSGWVG
--ASFPPSVSVMWLLSSGSSFLASFLCWEPLKVLLEALYFAL----------------VAKRLHPDEDDTLVESP-AVTP
VS---------------------ERVPRVRPPHGFALFLAKEEARKVKRLHRMLRGLLVYMFFLLVTLLANYGDTS----
-CHNHAY--RLQSAIKQELDS----------QAFLAITRSDEFWPWMSHVLLP-YIHGN----------QSRPE-----L
GPPRLRQVRLQEALCPQP-----------------PGSRNPACSAASSGFSTSDYGVGWGS-------------------
---------AALNSSEIWAYSAPDLLGVWSWGSCAVYDSGGYVQELGPSLEESRAQLGFLQLHNWIDNRSRAVFVELTRY
SPAVGLHAAVTLRLEFPAAGHAVAALSVRPFALRRLSAGLSLPLLTSVS---LLLFAVYFSVAEVRAWRREG--------
-------------------------------------------------------------RARATRAGTWARWLLVVLT
AAAALVRLAQLGAADRQWTRFLRRRPRRFT---------------SFEQVAQLSAVARGLTASLLFLLLVKAAQQLRFVR
QWSVFGKTLCRALPELAGAA-----LGLVVLAAAYAQLAVLLVSSCVDSLRSAAQALLVLCPGTGVPA------------
--LCPAESWRLSPMLCTGLWALRLWGALRLGSVLLRWRYHTLRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH
KVRFEGMEPLPSRSSRDSKASPDVPPPSGGSDASRPSTS--SSQLEGLS-------------------------------
-LGLGRPGPR-ELEPEPSRLHAVFEALLTQFDRLNAT-EDVYQLERR-LQLHGRRS------------------------
-------------------------------------------------------------------------SAPLASQ
PPSPSPGLRPVLPSRLARASRGIGLSTGPS---------------RASLRAKNKIHPSSS--------------------
------------------------------------------------------------------------------
>Monodelphis_domestica_PKD1
MPRGQGPPLAAPSPHGHGGPRPPPAPAPAPARFAFCLCLGLCIGGLSAAPDPGCQPCGLDCNCTPGPGGACSVNCSGRGL
RGLGPELPIPPDVTALDLSDNFINT---LETEFFENLSALTQLDISNNKILTLEEGIFANLFNLSEINLSLNPFICDCNL
SWFPSWVDEQKVSVVQPRETRCAEPPRLADVPILSVSFSDGTCDLEYIACVQDN----SSSAMTVVIFSAALDGEFTRNT
CSAFCFSFGQQYGGLSEEGRCFCGTARSPNASSGCLRFCPGLAAPP-VACRVPFILHNVFP-ASLEASLWGPGGPQPAGH
PVVFNVSTPLPANNLRWDFGDGAP-ALIAGPA----ASHRFILPGHYNVTAVLTLEVGTALLWTEVQVEAVPTELELLCP
SWLQSNESLE--IGVRNRGGTGLSATYSITAESEQPAQ-----VVHPLCPSNTDIFPGNGHCYRLVVEKAAWLQAQRHCL
AWGGGDLAIVGSPEIQRFLVSQVTR--SLDVWIGFTALTGPG----VPPHGEAFSLESCQNWLPGEPHPANAEHCVRLGP
AGQCNTDLCTATHSYVCEFQPTGIVSSADNFFVGDAGSDLPGPTV-PVEERDFLSAPGRETVEVMIFPGLEMQQKGFLTA
AEFETQDLMQPVQMRLQVYRP-VE----------GGIPENSSQPLCPSMDNQ-TWVPLDCLPGEHWCPLANLCLPLDSPC
SLSPCANDSS-------PEQDNHWSGHYSLWREFLFSLPAGPSSQYSVSFSGKNISLLPGDLFSLQHDAGPG--------
SLLRFLPRPEALPHQRFQPECLSANASTWLPSLPAHFS--------------------------EVPVPNGSTCALRLLF
ATEQVTRLLGQPSNPGLQHVGRYLFRASLDNGVSSHNLSCSFHVLSPVAGLRVIHPMP-QGGLFYVSTNW-TYLVLKISS
GANS--TARRLGSNQSVPFEASCPLGVARLTADCARETND---------SWFALLEL---DGLGEDESLVEIVAENRVSL
ENISIQVKAEEPIRGLSATPNPQTRVLQSTLVRYSPVV-----EAGSDVVFKWTIDDKQSLTFYNVVFNVIYQSAAVFKL
SLTASNHVSNVTVNYNVTVEKMNKMRDLVVSEVPAIIPQNTT------LQLGASVQVDSAVEVTFLWTFGDGEQ-ESGQF
KPPYNESFLVPEPGVHQVLIEHNVTHTYHV---PGDYNITVFVYNTLENLTQQVPLSVRASLPHVTVRTDSGALGVGHPI
TFMPHPLPSPTGILYTWDFGDGSPVVLQNQPEVTHTYVSR---GVYNISLTVNNTVSSVGARL-SVRVFEEIRGLRVTST
AATEKGMAVVVNASVEAGDNITWTFDMGDGTVLT-GPEASVQYVYLKDENCTIQVTAANPVSSVFQVLPIHIFVLEVLKI
EPSSCIPEQPEVQLTAHVTGDYTHYVFDWTFGDGSSNATVYGHPTVMHNFTRSGVFPLSLVLSSLVN---KAHYFTSVCV
EPEVSNITLQPERQFVKLGEEATLEVQAFP--PFLYRYSWDFGANDSAR--SGGTEASHTYRVPGIYLVTVTVSNNVSSD
NDTAFVEVQEPLGITSIEVNSSH--VLELSQPYLFSVLGSGSPASYRWDLGDGQRQEG-LRVIHAYNHTGSYTISVVGWN
EVSRSEAQLNVTVKRRIQGLSVNASRTVVPLNGSVSFTTTLEAGSDVHYSWVLCDRCTPILGSSTISYTFRSVGTFNIIV
TAENEVSSLQDSIFIYVLQQIEGLQMLGGGE--G---------GCFPTNRTLQLQAAVRDGTNISYSWALQQDG-G--LS
HAAHGKVFSLTVLEAGTYHVQLKAINMLGSAVVNRTLEFVEEVGQLAASASPNPAAVNTSVNISAQISSGTSITYAWLLQ
-EGVSVEAAEPFIVHSFSSPGLWAVTVTAGNQLGSVNATVHVDVQEPVAGLTVGCG-ESGSRFVASGSLVYFWGDLELGS
NVSWSWELP-----DG--PRSGQRIAAVFPHAGAFSIRLNASNAVSWTTASCNITVEDPIQGLELWASSRVVEPGERVQF
NIHLTAGSDVNYRLLISG--GVTTALG-EPHFSHSFPRVGDYMVTVQAENHVSWEQVQVRITVLEAIGGLQIVGCCELGI
PTGGERNFTARVQRGSRVSYAWYFSLQKVQGDS-LVILSGREVTYTPVAAGQLEIHLHAFNDLGSVNLTRTIEVQDLIQA
VELHPES--CFTNRSAQFEAATTPSPRRVFYRWDFGDGSQ-THVTATPSSNHTYLFPGDYTIKVNASNLVSFLVAKTTVT
VRVLECEEPEVEVALPTQVVMCRSQRSYLEAHINLRGCVTYQTEYHWKVYRAASCLHYRRSAH-------------VPLP
GVDVSRPQLVVPRLALAVGDYCFVFVVSFGDTPLSRSIQANVTVTPGRLVPIIDGGSYRVWSNARDLVLDGGKSYDPNLE
DGDQTLLSFHWACVSSSKSHPGG--------CPLNFGP---RGSSIITIPKERLEAGVEYTFNLTVWKAGRKEEVTNQTV
LIRNGLVPIVSLECVSCKAQS--VYEVSKSSYVYLEGTCHNCSSGSKRGRWAAQTFSNKSLVLDESTTSTGSSGMRLVLR
RGVLRDGEGYTFTLTVLGCSGEEEGFASIDLFPNRPPIGGSCRLFPHE--------------AVKALTTKVHFE-----C
TGWRDTEDENAPLVYSLLMRRCR--QGYCEEFCIYKGSLSAYGAVLPPGFKT----HFTVDLSVVVQDQLGAAVVALNKS
LLITLPEPSPSFHC----LTHWLYSLTETVLPGLVKQADPQHVIEYSLALISVLNEY----EQVTSSEEEASHERQLRGL
MRKNITEMLVSLRVNTVD---DIQQISAALAQCTVASKEFVCPSCLRKTLNKLENMMAILQNETTQGTVTPTAIADNILN
ITGDLIHLVNSDPQGL--------------------------VPTELCAAGG--LMASRAYNLSSDLMRILMKSRVLNEE
PLTLAGEEIVAQGKRSDPFSLLCYENTS--D---CQFSIPPAFNSTFS----------DLTDVVQLIFLVDS--NPFP-F
GYISNYTVSTKVASMAFQTQAGAQIPIERLGSEKAITVKVSNNTSGGGGGDRVLS------TSTAIIQPRTSVSAIIAPE
NHNPEAGLHFQLTYTVLNE-----RYLSEEPEPFLAVYLHSAPQPNEY-NCTASKKIGLKALAG---GDHRPYTFFISPG
TDDTTASYYLNMTSHFH----W-----SEVEVTVGLYTSLCQYFSEKEMMWKTEGIV-----------------------
----PLEETSP---------------------SQAVCLTRHLTAFGAS--LFVPPSSIQFIFPEPAPGINYIVLLTCAVC
LATYVVTALIVHKLDLMDVSR-VSIIPFCGK----NGRFKYEILVKTGWGQGSGTTAHV--G-----ITLYG-ADGRSGH
RHLDGESA---FHRN-----------SLDIFQIATQRSLGSVWKIRVWHDNKGLSP----AWFLQHIIVRDLQTGRS---
----------AFFLVNDWLSVETEDNGGLVEKEVLAASDATLRRFPRLLTAELQRGFFEKHIWLSLWDRPP---------
-----RSRFTRVQRATCCALLICLFLGANAVWYGVVGDASTPPSHPEPLIPLSVDTVAVG--------------------
---------------LVSSVVVYPLYLVILFLFRMSRSKVSVSPDRSPA-GQQMLDIDNYLETSVLDSSFLTLSGLHAE-
AFSGQTK---------TDLFLDDSKSLMHWQSSDGTLSWPDLLSDPSIMGNT----------------------------
----LQRLVRARAGNPPGLET----MEEDGLSLGSPPSQTKYFSTSDEDLIRQILAEGASSIAPARDT------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------HLETDLLTGLSGTLG
AKTEALM--LQRLNEKGLP------PAAPTQELVQSAKFTRGGLAEGLRKRLLPPWCAPLAHGLSLLLVLVAVGISGWIG
--TNFTSSVGVMWLISGIFSFLSSFLFWEPLKVLLEALYFSL----------------VAKRLHPEEDDTLVECP-AVEP
VC---------------------ERIPRVRPPQGFALFQAKEEARKVKLLHRMLKNFLVYMLFLLVTLLTNYGDAS----
-SHTHAY--RLQSSIKQELDS----------KAFLGITRSDEFWGWMSRVLLP-YVHGN----------QSALE-----L
GPPRLRQVRLQEGLCPDA-----------------LGSVRRVCATSS-SFSTKDYEVGWES-------------------
---------SSPNGTRAWAYSAPDLAGVWYWGYFSVYDSGGYVQELGVSLEESRELLGFLQRHNWIDNMSRAIFVELTQY
SPAVGLHAAVTLRLEFPVSGRALTAISVRPFPLQRLSAGVTLQLLMMVF---LMLFVVYFVVAEALAMQKEG--------
-------------------------------------------------------------QAYLVRAGAWGQWLLILLT
TATVLIHLSQLSLADQQWGRYLKRRPHHFT---------------SFYQVAQLSSAFASLAASLLFLLMIKAAQQLRFIR
QWSVFGKTLYRSMRELVAAG-----LALLVLAVAYTQLGFMLFSSCSDSLRSMGWDLFLLCPAGGDPH------------
--VCPSEPWRLSPLLCTSLMVLQLWGALRLGAVVLRRRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRH
KVRFEGMEPLPSRSSSDSKSSQDVSPPSAGSDTSRPSTS--SSQLDGMS-------------------------------
-LLMGRAGARGDPEPEPSRLLSVFEALLAQFDRLNQATEDVYQLERRLQGIQGWRSRDHLASPPWAP-------------
-------------------------------------------------------------------------GPPIPSP
SPGPPAGNQGTLPARIARASRGIGMAATQAS--------SGSPLVRASIRAKNRIHPSLT--------------------
------------------------------------------------------------------------------
>Gallus_gallus_PKD1
----------------------------------------------------------------------------QGLE
FIGNKQRLISEISILRDLSRNKISA---LDVQMFRSLTSLAKLDISHNKISTLEEGIFDNLFNLSEINLSWNPFFCDCKL
SWLPRWVEDRKVTVLQAADTRCAHPPGVANLSLFSVSFVNATCGAQYVTCLTSNH---TDEAELVILFTSSHPGNLTEET
CSALCYADDQEYGGFSPQGQCLCGTAHEPNSSSSCLLFCTEHSSG--QACGGPSLIHFPFQ-AQLSVSFIGLKPRYSLHE
AVLFNVSIPIAVSTLIWEFGDQTEVLNTTGNA----AVHTYALPGQYNVTATLFVGTKVSYVQAEIEVVASPQQLELQCP
SLIKTNESLD--IRIRNRGGTGLTVLYGITAESGEPGR-----AVHPMCPHDGLVFPGNNHCYQLVVEKAEWLEAQQHCQ
EHGNGELAFVSSPEIQSFLVTHVIRR-SLDVWIGFNDFASSE----AQQRGEGFNIESCQNWLPGEPHPSNADHCVRMGP
TGQCNTDLCMAKHSYVCEFKPKGVLLNAENFFVGDPVFDTHVAAK-NVIED-TLSSP-LQAVEVMVFPELAFRHEGYLSA
LEFVTQELHQPIQMRFQVHRPIDGKE--------YQEGQNATEPFPTSQDDG-NYTLVECPPGFQWCHLTNLCSSVNNCC
NAMECTNSSFASSPIPASPQHKGSQLSYELVKEFLFTIPAGPSAPYLVTFSKEDVFVRAKDVLSIQHNAGMG--------
SFLQCQP----STTSPFRTNYFSTNSSDWALGLPASSI--------------------------GATWIHNTVCSLRVLY
AKEQLVPIIS-PQNAGLAHPGLYTVRASVDNGIFSANLSCNFWVTSQVSGLRVVHPAP-QGGKVYVPSDH-ITLVVKISS
GMNAT--ARWLGDNHTFPFEEACPLTIAPLTSDCARENND---------TWFAVLSL---SGLKEGASTHTLVAENAISS
QNITITIKVEQPIRGLRATPDPESRVLLNTRVSYVPVM-----EAGSDVTFRWTVDDKPSFTFYNVVFNVIYQSPAVYKL
SLTASNHVSNFTVNYNVTVEMMNKMKNLTVLGIPPVLPQNST------VEFTARVQVDSAVDAMFLWDFGDGIQ-ETYQF
TPPYNKSFLVPDPSVHEVIIEHNVSHVYEY---PGDYILVVQVSNQFENLTCLTPVRVHSYLVDVQIETVKDVLVVNRSV
TFRAIPLPSPYGVLYTWDFGDGSSLVTESQSTVTYSYSSR---GVYNISVSANNTINSVETVE-CYQVFEEITGLHVAAD
EVAEVGATVTLNASVQTGDSITWIFDMGDGTVLR-SQVPVVEHVYTKDINCTVNVTAVNPVNSVSQTIPVWIFVLEVLRI
DPTSCILEHPDVQLTAYVTGNPDEYIFDWTFGDGSSNVTVSGDPVVMHNFTRSGTFPLSLTLSSRFN---KAHYFTSVCV
EPEIVNVTLLPSKQFVRLGEECSFQVSAVP--LYQYRYRWDFGNNESTR--SSGTEVSYNYKSTGVFLVTVTVSNNVSFN
NDTAFVEVQEPVGVAKIEYNGTK--VLELNQIYLFSASMNGTKVNYFWDFGDGITQPG-QITTHSYNNTGHYTISVTGQN
DVSTNETRVDVTVKRRLHGITINASRTIVPLNGSVSFVATLVAGSAIRYSWILCDRCTPIQGSSTISYTFRSVGTFNVIV
TAENEISSLQDSIYVYVLEQIEGLQVASSDLVED---------LYFPTNKTLHLHAVVREGTNISYSWIAQKDG-N--AV
QTATGKTFSLNVLEAGNYTVYLKATNMLGSTTANKTLEFIESLGLLKPYAFPNPVAVNASVNISATITSGTGIVYVWYLE
-DGLSPVTSESFIIHSFQSPGAMEVVIGAENKLDSTNATISVYVEEVIEELSIGTA-ELDCRYVSSGSTVVFEGELQKGT
EVTWLWEVP-----NG--TLTGQSVAVMFPTAGFYTVYLNASNDISWAVASRNISVLDRIQGLEVIASKKVVEPGEQVTF
VIRMSSGTSVSYLVSISG--DYSVVLN-GSKYTHEFTKSGDYLVTVTVQNQISIAHAQVLISVLEAVRDIRLLNCCERGI
PTGTEKSFSAQVGSGSRVLFSWQFSLWKERGRS-VVTAAGESVSYTPEAAGLLEIHLRAFNDLGGINITRTIQVQDPILQ
VSLTASN--AFVNRTALFEAAVIPNGRGVEFLWTFGDGSS-TQMTRVAVANYSYLSPGDYLVEVNATNLISFFVAHLTVT
VKVLECEEPEVELALPPQVVMKRSQRNYLEAQLDLRGCIKYQTEHLWEIYRAPSCLHLDDSSR-------------IHLP
NVDVNRPQLVIPKLALEVGNYCFVFIVSFGDTPLSKSIFANVTMIPSKLVPIIDGGSYRVWSNTQDLILDGEKSYDPNLD
DGEQTPLFYQWSCTFSSKSSAAG--------CSLNFSA---NGG-NVTIPKAVLEADVEYTFNLTVWKKGMNPEATNQTV
FIKRGGVPIVSLECVSCKAQS--VYEVSKSSYVYLEGTCQNCHNDSKIGRWAAHSFKNKSLILDKKTTSTGDTGMNLVLR
QGALKDGEGYTFTLHITDLTTGEEGFASIDLLPNQPPIDGSCQLSPKG--------------PLRALMAKVHFE-----C
TGWRDTESAEDPLVYILLASRHR--AGHYHEFCVYKGSRAEHSAFLPPGFHES---GFVVSVSVLVQDQLGATVVAINQS
MEIGLP---EGFPS----LSYWLYNQTDTVLQGLVKQGDPQQVIEYSLALITILNEY----ERSMLLEPETGNEFELRTW
TRNNITETLNSLNVNTVD---DIQQISAALAQCTVVSKELVCKSCLTRTLNKLESMMTILQGEMTQGTVTPTGIADNILN
ITGDLIHLVNTVSQES--------------------------KPQELLADSHNLLLAPKAYNLSSSLMRILMKSRVLNEE
PLELVGGEIKATGKRSDPFNLLCYENTP--N---CQFSIPQAFNTTLS----------NLTDVIQVMFQVDS--NPFP-F
GYINNYTVSTKVASMEFQTYNGVQIPIGSLDSERAITVMVSNNTDADNLS-----------AGTEVIEARTSVNLIVTME
NNNREAGLHFRLTYKVLND-----RYVASEPEPFIMAYLHHEPEPNEH-NCTASKKISLEALSG---SDHKLYTFFTSPL
TDDTIQKYYLNITNHFS----W-----SPVEVTLGLYTSLCQYFSEQEKRWKTEGII-----------------------
----PLEETRP---------------------DQAVCLTQHLTAFGAS--LFVPPNSVQFIFPAPGSGLNYIVLLTCAVC
FVTYSVAALIVHKLDMIDINR-VGVIPFCGK----NGLYKYEILVKTGWGRGSGTTAHV--G-----IALYG-VDNKSGH
RHLDGENA---FHRN-----------SLDVFQIATERNLGSIWRIRIWHDNKGLSP----SWYLQHVIVRDLQSSKS---
----------YFFLVNDWLSVESEENDGMVEKEVYAASETELRSFSRIFIAELQRGFFEKHVWLSMWDRPP---------
-----RSRFTRVQRATCCSLLIFLFLCANAVWYGVVGNVHLSSGAVSNLIPVNVDTVAVG--------------------
---------------LVSSVVVYPLYLVILFLFRMARAKVSINHTVTHS-DQQSLEIDNYLDSSVLDSSFPTFPGLRAEQ
AFSEQTK---------TDLFLEDSKSLIRWPSSEALLSWPDLLSDPSIMGNT----------------------------
----IQKLKRGRASRHLGLEAPLA-TEEDNLSLGVHQGQPRYFSASDEDLIRQILADGASGISHSQDLGPYM--------
--------------------------------------------------------------------------------
-----------------------------------------------------------------RAETDLISGLSSVFG
EKVETVM--MQKLNDKGQ------SMAAPPREVSRSAKSTWTVADQTFRKRLLPSWCSYLAHGISFFLFATSTGVSVWIG
--VGFSSSVALMWLISGIFSFLASFLVWEPLKVLLEALYFSL----------------VAKRLHPEEDDTLVEHP-FVEH
VS---------------------EKISKVRPPQGFALFQAKEEARKVKLLHRMLKNFLIYMMFLLVILLTNYGDAT----
-RNSRAF--LLQSSIKQQLGS----------SEFLHIKRSDQFWVWMSQVFLP-YLYNN----------QSGQESYSTTL
GVARLRQLRLQEVLLP---------------------PEIEKNCIDSHSFSTADYAAGWER-------------------
---------AAVNVTTAWSYSPPDLTGVWYWGYISFYDSGGYIQELGTSLEEGRAQLNYLQQHTWIDNMSRVVFVELMQY
NPSVDLHAAITLQLEFLGAGQAVTTVTISPFPLLRLSSGVTLQLLMMVF---LMMFVVYFVVSESLSIKKEG--------
-------------------------------------------------------------RAYFTLWGNYGQWVFILLT
TCTVVVHLSQATLADQQWLKYLNNR-KVFT---------------NFYQVAFLNTVFSTLAASLLFLLIVQAAQQLRFVR
QWSVFGKTFQKSMKELTAAG-----LAFVVLILAYAQLGFLLFSSSSESFRSVGSSLLLLIAMVRGGVSLY---------
--PCPPDSSGLYYLFCTSYIILEVWIVLRLFTVVLVYSYREMHFEMYRPAFEPQDYEMVELFVRRLKMWMGFSKAKEFRH
KVRFEGMEPLPSRDSSDSKSIR-GPTPSAASDSSRASTS--SSQLDGLS-------------------------------
-LVLSTRDSLEVDAD-LQRLLSLFEMLLAQFDRVNQVTEDVYRIEHQLQGSQSRRSRRRY--------------------
---------------------------------------------------------------------------CAGNT
ERGPSPETRSSVPSHLIRASRGISGAASVLPPHKAHSTLAPAVKKKRPLRAKNRVHPTVK--------------------
------------------------------------------------------------------------------
>Taeniopygia_guttata_PKD1
--------------------------------------------------------------------------------
----------------------------------------------------LEDGIFDNLFNLSEINLSWNPFVCDCKL
SWLPRWVEERKVRVLEASDTRCAHPPEVANLSLFDVLFLNATCGAQYITCLTGNY---TEEAELIILFTSVHPGNLSEET
CSALCYSQEQEYGGFSPQGQCVCGAAHETNSSSGCLPFCTEHLSG--QGCGGPSLVPLPFQ-AQLPVSFTGLQPRYSLHQ
PVLFNVSIPIAASTLLWEFGDRSEVLNTTAHT----AVHSYALPGRYNVTATLLVGSRLLQEQAEIEVVASPQQLELQCP
SLVVANESLD--IRIRNRGGTGLAVLYGITAEPGQLGR-----AVHPMCPPEGLVFPGNNHCYQLVVEKAEWLEAQRHCQ
ELGDGDLAFVSSPDIQSFLVAHVIR--SLDVWIGFNDFASSG----AQQRGEGFNLESCQNWLPGEPHPSNADHCVRMGP
TGQCNTDLCMAKHSYVCEYKPPGVLLNAENFFEGEAELGTEEAVR-SVSEA-VLADP-WQAEEVLEFPELAFRHQGFLTA
LEFVTQELHQPVQVRFQVWFCS----------------FEEIKPWGSGLEKI-TEEKPLSMPEESWCPLTSLCSSHNSCC
NGTECANSSFGSSPAPGAPQPSDSQPSRELLKELLFTVPAGPSSQYQVTFRKENIFVRAGDVFSIQHSAASG--------
SFLRCRR----RAASAGRG-----NCSAWAAGSCHSPA--------------------------GAPRANSSACSLRVRY
AEEQLVPVLS-PHNAGLERPGGYAVRASVGNGLFSANLSCGFRVASRVSGLRVLHPAP-QGSRLYLPTNH-TALLLKLSS
GVNAT--ASCLGDNRTVPFVATCPPALAAL---CARETND---------TWFAVLQL---GGLGQGLSTHVLVAENSVSS
QNITVTVKVEEPIRGLRATPDPESRVLLNTRVSYIPVM-----EAGSDVTFRWTVDDKPSFTFYNVVFNVIYQSPAVYKL
SLTASNHVSNFTVNYNVTVEMMNRMRNLSVVGALPVVPQNSS------VEFSARVHVDSAVEALFLWDFGDGVQ-ETYLF
KPPYNKSFLVPDPSVHEVVIEHNVSHIYQD---PGEYALMVVVSNQYENLTHLSPVQVHSYLVDVKVEAEEDVLVVGRPV
TFRAAPLPSPYGVVYTWDFGDGSSLLTDTQPSVTYSYPRR---GVYNVTVTANNTVSSVETVE-CYQVFEEVTGLRVSTA
EAAEQGAAVTINASVETGDSITWIFDMGDGTVLR-SQVPVVEHVYIKDINCTVNVTAVNPVNSVSQAVPVRIFVLEILKI
EPTSCILEHPDVQLTAYVTGNPEEYIFDWTFGDGSSNVTVSGDPVVVHNFTRSGTFPLTLTLSSSFN---KANYFTSVCV
EPEILNVTLLPSKRFVRLGEESSFQVSAVP--PYQYRYRWDFGNNESTR--SSGTEVIYTYKNTGVFLVTVTVSNNVSFN
NDTAFVEVQEPVGVAKIEYNGTD--VLELNQIYLFSASMNGTKVSYCWDFGDGTVQPG-QVATHSYNSTGHYSITVMGQN
DVSSNETTIDIAVKRRLFGLTVNASRTVVPLNGSVSFVATLVAGTAIRYSWILCDRCTPIQGSSTISYTFRSVGTFNVIV
TAENKISSLQDSIYVYVLEQIEGLQVASTDLVED---------LYFPTNKTLHLQAVVREGTNISYSWVVQRDG-N--AV
QTFTGKTFPLSILEAGNYTVYLKATNMLGCATANRTLEFMESLGVLKPYAFPNPAAINASVNISATITSGTGVTYVWYLE
-DGSSPATSEPFILHSFQSSGMIEVIVGAENKLNSTNATVSVCVEEVIEGLTIGTA-ELDCRYVSSGSTVVFEGELQRGT
EVTWLWQVP-----NG--TLSGQSVAVTFPTAGLYTVHLNASNHISWALASRNISVLDRIQGLEVVASKKVVEPGEQVTF
EIRMLSGTSVSYLVSISG--DYSVVLN-GSRYNHEFTKSGDYLVTVTVQNQISIAHAQVLISVLEPIQDLRLLNCCEEGI
PTGTEKSFSARVGSGSRVSFSWQFCLWKERGRS-VVAASGERVSYAPEAAGLLEIHLTAFNDLGSVNITRTMQVQDPIVQ
VSLSATN--AFVNRTALFEAVVVPSSRSVEFLWSFGDGSS-TQTTRVAVANYSYLSPGDYLVEVNATNLISFFIAQLTVT
VKVLECEEPEVELALPPQVVMKRSQRNYLEAQIDLRGCIKYQTEHLWEIYRAPSCMNLDDSSR-------------IRLP
NVDVNRPQLVIPKLGLEVGSYCFMFIVSFGDTPLSKSIFANVTVIPSKLVPIIDGGSYRVWSNTQDLVLDGEKSYDPNLD
DGEQTPLLYEWSCTSSSKSSAAG--------CSLNFSA---KEG-IVTISKALLEADVEYTFDLTVRKEGMSPEATNQTV
FIKRGGVPIVSLECVSCKAQS--VYEVSKSSYVYLEGTCQNCHNDSKLGRWAAHSFKNKSLILDKTTTSTGDTGMNLVLR
PGALRDGEGYTFTLHITDLTTGEEGFASIDLLPNQPPVGGSCRLSPEG--------------PLRALVTKVHFE-----C
AGWRDTEDAEGPLVFILLASRHR--PGHFHEFCVYKGSRAEHGAFLPPGFHES---GFQVSVAVLVQDQLGATVVAVNRS
MEIGLP---EGFPS----LSHWLYNQTDTVLQGLVKQGDPQQVIEYSLALITILNEY----ERSVLLEPEAGQEFELRTW
TRNNITETLNALKVNTVD---DIQQISAALAQCTVVSKELVCKSCLTRTLNKLETMMTILQGETTQGTVTPTGIADNILN
ITGDLIHLVNTVSQES--------------------------KPQELLADSHNLLLAPKAYNLSSSLMRILMKSRVLNEE
PLELVGGEIKATGKRSDPFNLLCYENTP--N---CQFSIPQAFNSTLS----------NLTDVIQVMFQVDS--NPFP-F
GYISNYTVSTKVASMEFQTHNGVQIPIGSLDSEKAITVMVSNSTEPENLV-----------AGTEVIEARTSVNLIVIME
SNNREAGLHFQLTYRVLNE-----HYLASEPEPFIMAYLHHEPEPNEH-NCSASKRISLDALAG---SDHKLYTFFTSPR
TDDPIQKYYLNITNHFS----W-----SAVEVTLGLYTSLCQYFSEQEKRWKTEGIV-----------------------
----PLEETRP---------------------DQAVCLTQHLTAFGAS--LFVPPNSVQFIFPAPGPGLNYIVLLTCAVC
FVTYSVAALIVHKLDVIDTNR-VGVIPFCGK----NGMYKYEILVKTGWGRGSGTTAHV--G-----IALYG-VDNKSGH
RHLDGDNA---FHRN-----------SLDVFQIATERSLGSVWRIRIWHDNKGLSP----SWYLQHVIVRDLQSSKS---
----------YFFLVNDWLSVESEDNDGLVEREVFAASESELRSFWRIFVAELQRGFFEKHVWLSLWDRPP---------
-----RSRFTRVQRATCCCLLIFLFLCANAVWYGVVGSVHLSNVAISSLIPVSVDTVAVG--------------------
---------------LVSSVVVYPLYLVILFLFRMARGKVSISHTVTHS-DQQSLEIDNYLDSSILDSSFPTFPGLQAE-
AFSEQTK---------TDLFLEDSKSLVPWPSSEALLSWPDLLSDPSIMDNT----------------------------
----IQKLKRGRASRHLGLEAPLA-AEEDALSLGIHQGQPRYFSASALNVIRQFLTDGHTGL--FQGLGPYV--------
--------------------------------------------------------------------------------
-----------------------------------------------------------------RAETDLISGLSSVFG
EKVETVM--MQRLNDKGQ------SVAPPPREVSRSAKSTWTGTRATFRKRLLPPWCSLLAHGISLLLLATAAGVSVWIG
--VGFSSSVALMWLISGIFSFLASFLLWEPLKVLLEALYFSL----------------VAKRLHPEEDDTLVEQP-CVEH
VS---------------------ERISKVRPPQGFALFQAKEEARKVKLLHRMLKNFLIYMMFLLVVLLTNYGDAS----
-RTSRAF--LLQSSIKQQLGS----------SDFLLIKRSDQFWVWMSQVFLP-YLYNN----------GSGQESHSTTL
GTARLRQLRLRGAECPGH-------------------PAGHGHCTDQHSFATADYEVGWES-------------------
---------TAGNGTAAWAHSAPDLAGIWYWGYISFYDSSGYVQELGPSLEQSRAQLEFLQQHTWIDNMSRAVFVELLQY
NPSVDLHVALTLRLEFPGAGQAMAAVTVSPFPLLRLSGGVTLQLLMMVF---LMLFVVYFVVSESLAIKKEG--------
-------------------------------------------------------------RAYFTLWGNYSQWVFILLT
TCTVLVHLSQATLADQQWLRYLSNR-RGFT---------------NFYQVAFLSSVFSSLAASLLFLLTVQAAQQLRFVR
QWSVFGKTFQKSMKELMAAG-----VAFALLLLAYAQLGFLLFSSSSESFRSVGSSLLLLLALLRGSASLR---------
--PCLPEASGLCCLFCTSYVVLEVWIVLRLLAAVLIHSYREMHFELYRPAFEPQDYEMVELFVRRLKMWMGFSKAKEVR-
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------
>Anolis_carolinensis_PKD1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------MDCPSGSHWCQLTNSCLPLGGCC
NKFESCANSSMASTPSPIAHRCPNPPSMVQVQESLFIVPPGPSMMYLLLFKNKDVSIGPNDTLSIQHDAGPG--------
AFLLCHR----NRVPSSPTSYFSWNSSAWEMDFHPSFH--------------------------ASKWHNDSECEFRLLC
TTEETSPIIR-KQNFGIPSPGFYTLRATISNTVFATNVSCDFGVESPISGLRVVSPPE-QGGILYVEANH-TFLVVKISS
-GGANTTVGWIGGNRSTLFEKTCPVSVVK----CGPKTDD---------TWFAVVSL---EGIAENGSTVVLQAENTVST
QNLTVVVKAEEGIRGLRATPDPESRILLNSRVTYVPRM-----DAGSEVTFRWTVDDKPSFTFYNEVFHVIYQVPAIYKL
SLTASNHVSNVTVDYNITVEKMNRMKDLLVSEVPQRAPQNGT------LDLAASVRVDSAVKATFLWDFGDGNN-ASSQF
QPPYNDSFLVPDPTIHQVVIAHNVSHAYQE---PGEYTLTVVVYNEFENLTYSVPIHIYSYLMDLTMEADTDVLVAGRPV
TFKAHPLPSGFGVSYVWDFGDDSMVYVESQPTIVHTYNTK---GIYNVSLRANNTISTMETFW-CYRVFEEITGLHVTME
EAIEVLMPLEISASSETGDNITWIFDLGDGTVVE-TSEASVNHSYLKEMNVTVNVTAMNPVNSVSRAVPIQVFLLMVLKF
EPSACIVEHPDVQLTAYVSGNAEDYVFDWMFGDGSPNVTVYGDPTVRHNFTRCGIFSLSLAISSKVD---KIHYYTVVCV
EPEVTNVTLFARSSFVMLGNESKFQVTALP--PYPYRYHWDFGTNDSLK--FGGTEVSYTYKAPGIYLVVVTVSNNVSFN
NDSALVEVQEPVGVARIESNASK--VLEVNQVYLFSANVSGTKVRYLWDFGDGTTQLG-KFITHSYNKSGIYAVSLKAWN
EVSFREARVNVTVKRRLQGLSINASRTVVPLNGSVSFTATLLAGTAIRYSWILCDRCTPILGSSTISYTFRSIGTFNVIV
TAENEIGCLQDSIFIYVLQQIEGLQIVGAGLLDN---------TYFPTNKTLQLQANIRDGTNISYSWAVVKES-H--SV
QTFTGKTFSLVILDAGVYIVHLKATNMLGTLAVNKTIEFIEPVGVLKLVAFPNPVAVNASINVSAAISAGTGLEYTWYLE
-NEVPVTTVFSSITHFFQSPGAKEVTVEAENKLGSTNATLMVFVQEPVTGLRIRTL-RPNCTYIESGSVVNFSGELESGS
DVSWVWKMP-----NG--TISGQRVALTFPTPGFSSVCLNASNDVSWEGACHNLTVQDAIRDLRLSVSKRVLEPGEEASF
SIGMSSGSSVRYEVSIAG--NQSMVLN-ASNFSYTFTRVGDYVVQVTAENYVSVVHTEVHIVVLEAVRGLRLVDCCEQGT
PTGVERRFAAEVEAGSRVSYQWRITLTEDEGRSQVATLEGPSISYMPEVAGRLDVHLQASNLLGGLNVTVVIQVQDLITQ
LSLLPVK--PFANRTTSFTVSVRPNARQVGFLWRFGDDSP-VLRTDVASASHTYLQPGDYLVEVNATNLISSSFARLTVT
VRVLECEEPEAELALPAQVVMKRSQKNYLEAQINLRGCTSYKTAYLWEIYRAPSCLQMGSADK-------------VHLP
HVDATRPQLVIPKLALDLGNYCFKFLVSFGDTPLSKSTFANVTVLPNKLVPIIEGGSYRVWSNTRDLVLDGGKSYDPNLE
DGEQTPLLYSWSCVSSSKSPSSK--------CALDFSA---RGG-VVTVSRAILEADVEYTFALSVWKEAMSPESTNQTV
FLKRGTVPIVSLECVSCKAQS--VYAVSRSSYVYLEGTCLNCQNNSKMGKWAAQSFKNKTLPLDRSTTSTGDAGMNLVLR
PWALKDGEGYTFTLRITDLASGETGFASMDLLPNQPPFGGSCWLSPMG--------------PLQALTAKVHFE-----C
TGWRDTENEGTPLVYVLLATRCR--SGHCEEFWVYKGSHAEHAAFLPPGFQEN---GASVSVSVLVQDQLGATVVAFNSS
LAITLPVVPEGFGS----LPQWLSNQTKVVLQGLVKQGDPQQVIEFTLALITILNEVG--RSHPASPGAEIEGDDRLRAW
MRRNITETLVSLNVNTVD---DIQQIAAVLAQCTVANKAFVCRDCLKKTLEKLESMMDILQGETMQGTMTPTAIADNILN
IMGDLIHLVNTASREL--------------------------VPQELGSGQSPVEVASKAYALSSDLMRILMRSRVLNEE
PLELAGTNITATGKRADPLGLLCYDQDD-PE---CQFSLPPAFNTTFS----------DLSDVVQVMIRVDY--NPFP-F
GFVANHSVSSEVASLEFQSHNGTEIPVGALEPEKAITVMVADPREKDIT------------AGTVVIEEAGSVSAALRVE
SRDPEAGLYFQVTFSVLND-----RYVSSEQQPSIAVCFFPAPEPGIVPNCTDTKEIYLEDMNRRPEGDHRQYTFFVSPV
TEEAEKEYFFNITNHFL----W-----SPVEVTLGLYGSLCQYFSPEEIRWKTEGLA-----------------------
----PLEGTTP---------------------ERAVCLTRHLTAFGAS--LFVPPHSLQFLRPPPGPGFNYIVLLTCAVC
LVTYFVAAVIVHKLDLIDINR-VGVIPFCGK----NGLYKYEILVKTGWGKGSGTTAHV--G-----ITLYG-MDSKSGH
RHLDGENA---FRRN-----------GLDIFQVATERSLGSLWKIRIWHDNKAYPT----FWIIQHIFVPRIANKVL---
----------LLYYYNPGLQINFEANHGPSRVKSLANMMATTYWSLRQMMG-----QYDDHDPLLDSSFEN---------
-----WWTSMVVVACCWASLWVKSLANMI