>Homo_sapiens_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------MERAGPSFGQQRQQQQPQQ------QKQQQ-------
-------------RDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKE---------------------
-------------GIRGHTESCSCPLQQSPR---------------ADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTV
SFLS----DSEKKEQMPLTPPRFD--------------------------------------------------------
----------------------------------------------HDEGDQCSRLLELVK-DISS---HLDVTALCHKI
FLHIHGLISADRYSLFLVCEDSSN--------------------------------DKFLISRLFDVAEGSTLEEVSNN-
----------CIRLEWN--KGIVGHVAALGEPLNIKDAYEDP--------RFN--------------------AEVDQIT
GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGN---GG-TFTE-KDEKDF--------------------------
--------------------------------------------------------------------------------
---AAYLAFCGIVLHNAQ-LYETSL------------LENKRN---QVLLDLASLIFE---------------EQQSLEV
ILKKIAAT-IISFMQVQKCTIFIVDEDC-----SDSFSSVFHMECE----------------------------------
--ELEKSSDTLT-REHDAN---------------------------KINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTEN
T-----------------GNVNQQCIRS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKVKPFNRND
EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQSLAAAVVPSAQT----------LK-
-------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM
KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLEILALLIAALSHDLDHRGVNNSYI
QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR---RGEF
FELIR---------KNQFNLE-----------------DPHQK--------------------ELFLAMLMTACDLSAIT
KPWPIQQR---IAELVATEFFDQGDRERKELNIEPTD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCFP--
------------------------------------------------------------------LLDGCRKNRQKWQA
LAEQQEKML-----------------------------------------------------------------------
----------INGESGQAKRN-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Macaca_mulatta_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------MERAGLSFGRQRQQQQPQQ------QKQQQ-------
-------------RDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKE---------------------
-------------GIRGHTESCSCPLQQSPR---------------ADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTV
SFLS----DSEKKEQMPLTPPRFD--------------------------------------------------------
----------------------------------------------HDEGDQCSRLLELVK-DISS---HLDVTALCHKI
FLHIHGLISADRYSLFLVCEDSSN--------------------------------DKFLISRLFDVAEGSTLEEASNN-
----------CIRLEWN--KGIVGHVAALGEPLNIKDAYEDP--------RFN--------------------AEVDQIT
GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGN---GG-TFTE-KDEKDF--------------------------
--------------------------------------------------------------------------------
---AAYLAFCGIVLHNAQ-LYETSL------------LENKRN---QVLLDLASLIFE---------------EQQSLEV
ILKKIAAT-IISFMQVQKCTIFIVDEDC-----SDSFSSVFHMECE----------------------------------
--ELEKSSDMLT-REHDTN---------------------------KINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTEN
T-----------------GNVSQQCIRS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKVKPFNRND
EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQSLAAAVVPSAQT----------LK-
-------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM
KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLEILALLIAALSHDLDHRGVNNSYI
QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR---RGEF
FELIR---------KNQFNLE-----------------DPHQK--------------------ELFLAMLMTACDLSAIT
KPWPIQQR---IAELVASEFFDQGDRERKELNIEPTD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCFP--
------------------------------------------------------------------LLDGCRKNRQKWQA
LAEQQEKML-----------------------------------------------------------------------
----------INGESGQAKRN-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Mus_musculus_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------MERAGPNSVRS----------------QQQ-------
-------------RDPDWVEAWLDDHRDFTFSYFIRKATRDMVNAWFSERVHNIPVCKE---------------------
-------------GIRAHTESCSCSLQQSPH---------------ADNTTPGAPARKISASEFDRPLRPIVVKDSEGTV
SFLS----DSGKKEQMPLTPPRFD--------------------------------------------------------
----------------------------------------------SDEGDQCSRLLELVK-DISS---HLDVTALCHKI
FLHIHGLISADRYSLFLVCEDSSK--------------------------------DKFLISRLFDVAEGSTLEEASNN-
----------CIRLEWN--KGIVGHVAAFGEPLNIKDAYEDP--------RFN--------------------AEVDQIT
GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGN---GG-TFTE-KDEKDF--------------------------
--------------------------------------------------------------------------------
---AAYLAFCGIVLHNAQ-LYETSL------------LENKRN---QVLLDLASLIFE---------------EQQSLEV
ILKKIAAT-IISFMQVQKCTIFIVDEDC-----PDSFSRVFHMECE----------------------------------
--EVGKPSDPLT-REQDAN---------------------------KINYMYAQYVKNTMEPLNIPDVTKDKRFPWTNEN
M-----------------GHVNTPCIGS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKIKAFNQND
EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQALSAAVVPSAQT----------LK-
-------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM
KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLETLALLIAALSHDLDHRGVNNSYI
QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIDEYKTTLKIIKQAILATDLALYIKR---RGEF
FELIR---------KNQFSFE-----------------DPLQK--------------------ELFLAMLMTACDLSAIT
KPWPIQQR---IAELVAAEFFDQGDRERKELNMEPAD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCLP--
------------------------------------------------------------------LLDGCRKNRQKWQA
LAEQQEKML-----------------------------------------------------------------------
----------LNGESSQGKRD-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Felis_catus_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------MVNAWFAERVHTIPVCKE---------------------
-------------GIRSHTESCSCPSQQSPR---------------ADSSAPGTPTRKISASEFDRPLRPIVVKDSEGTV
SFLS----DSEKKEQMPLTPPRFD--------------------------------------------------------
----------------------------------------------NDEGDQCSRLLELVK-DISS---HLDVTALCHKI
FLHIHGLISADRYSLFLVCEDSSN--------------------------------DKFLISRLFDVAEGSTLEEASNN-
----------CIRLEWN--KGIVGHVAAFGEPLNIKDAYEDP--------RFN--------------------AEVDQIT
GYRTQSILCMPIKNHREE-----VVGVAQAINKRSGN---GG-TFTE-KDEKDF--------------------------
--------------------------------------------------------------------------------
---AAYLAFCGIVLHNAQ-LYETSL------------LENKRNQA-KVLLDLASLIFE---------------EQQSLEV
ILKKIAAT-IISFMQVQKCTIFIVDEDC-----SDSFSSVFHMECE----------------------------------
--ELEKSSDTLT-RERDAN---------------------------RINYMYAQYVKNTMEPLNIPDVSKDKRFPWTNEN
T-----------------GSVSQQFIRS---LLCTPIKNGKKN---KVIG-VCQLVNKMEENT-------GKVKPFNRND
EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEETRELQSLAAAVVPSAQT----------LK-
-------------ITDFSFSDFELS-DLETALCTIRMFTDLNLVQNF-------------------------------QM
KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKA---GKIQNKLTDLETLALLIAALSHDLDHRGVNNSYI
QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR---RGEF
FELIR---------KNQFNLE-----------------DPHQK--------------------ELFLAMLMTACDLSAIT
KPWPIQQR---IAELVATEFFDQGDRERKELNIEPAD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHVSEDCFP--
------------------------------------------------------------------LLDGCRKNRQKWQA
LAEQQEKML-----------------------------------------------------------------------
----------INGESSQAKRN-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Gallus_gallus_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MERSCHPSPEQEAVEAWLDDHCDFTRSYFVRKATREMVNAWFAERVHTIPVCKE---------------------
-------------GTKSQSE--SCACQQLAC---------------SENTNSGTPARKISASEFDRPLRPIFVKDSVGAV
SFLS----GSEKKEQMPLQSPRTG--------------------------------------------------------
----------------------------------------------TSAGDRCSRLLELVK-DISS---HLDVTALCHKI
FLHIHELIAADRYSLFLVCEDSSN--------------------------------EKFLVSRLFDVAEGSTLEEASNN-
----------CIRLEWN--KGIVGHVAAIGQPLNIKNAYEDP--------RFN--------------------AEVDQIT
GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGT---GG-TFTE-QDEKDF--------------------------
--------------------------------------------------------------------------------
---AAYLAFCGIVLHNAQ-LYETSL------------LENRRN---QVLLDLASLIFE---------------EQQSLEV
ILKKIAAT-IISFMQVQRCTIFIVDEDC-----TDSFSSVFHMEAE----------------------------------
--ELEDSAENQK-RDCDTN---------------------------KINYMYAQYVKNTMEPLNIPDVCKDRRFPWTTDS
A-----------------ESVSQHIKS----LLCTPIKNGKKN---KVIG-VCQLVNKMEENS-------GKIKAFNRND
EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAAEEESRELQVTAAAVVPSAQS----------LN-
-------------LTDFNFSDFELS-DFETTLCTIRMFTDLNLVQNF-------------------------------QM
KHE-VLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALKS---GKIQSKLTDLETLALLIATLSHDLDHRGVNNSYI
QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---SPGNQILSSLSIEEYKATLKMIKQAILATDLALYIKR---RGEF
FELLR---------KKQFNWE-----------------DPMQK--------------------ELFLAMLMTACDLSAIT
KPWPVQQR---IAELVATEFFDQGDKERKELNIEPTD--LMNREKKNKIPSMQ-VGFIDAVCLQLYEALTHVSEACYP--
------------------------------------------------------------------LLDGCRKNRQKWQS
LAEQQEKNL-----------------------------------------------------------------------
----------INGESNQAKRN-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Anolis_carolinensis_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------KAWILLFWDFLLNLLRERRGREMVNAWFSERVHTIPVCKE---------------------
-------------GTKTHSETCSCSTLQTTR---------------SENTNSTPPARKISASEFDRPLRPIVVKDSIGTV
SFLS----DSEKKEQMPLQSRTLR--------------------------------------------------------
----------------------------------------------TDAGDQCTRLLELVK-DISS---HLDVTALCHKI
FLHIHELIAADRYSLFLVCEDSSN--------------------------------EKFLVSRLFDVAEGTTLEEASNN-
----------CIRLEWN--KGIVGHVAALGQPLNIKDAYEDP--------RFN--------------------AEVDQIT
GYKTQSILCMPIKNHREE-----VVGVAQAINKKSGG---GG-TFTE-QDEKDF--------------------------
--------------------------------------------------------------------------------
---SAYLAFCGIVLHNAQ-LYETSL------------LENRRN---QVLLDLASLIFE---------------EQQSLEV
ILKKIAAT-IISFMQVQQCTIFIVDEDC-----SDSYSSVFHMEFE----------------------------------
--ELEDSNETHK-RDYDTN---------------------------QINYMYAQYVKNTMEPLNIPNIRQDKRFPWTPFN
V-----------------NNVNAQKVCPKQLLLTTEKELGEKNETPNDPG-VCQLANKMEENS-------CKIKAFNRND
EQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLE--VLSYHASAADEEARELQVTAAAVVPSAQS----------LG-
-------------LTDFYFSDFELS-DMETSLCTIRMFTDLNLVQNF-------------------------------QM
KHE-VLCRWILSVRKN-YRKNVAYHNWRHAFNTAQCMFAALKS---GKIQNKLTDTEVLSLLIAALSHDLDHRGVNNSYI
QR--SEHPLAQLYCHS--IMEHHHFDQCLMILN---TPGNQILSGLSVEEYKATVKMIKQAILATDLALYIKR---RGEF
FDLLR---------KKQFNLE-----------------DPYQK--------------------ELFLAMLMTACDLSAIT
KPWPVQQRKTQIAELVAAEFFDQGDKERQELNIEPTD--LMNREKKNKIPSMQ-VGFIDAICLQLYEALTHISEACYP--
------------------------------------------------------------------LLEGCRKNRQKWQA
LAEQQENNL-----------------------------------------------------------------------
----------INGESNQPKRN-----------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Xenopus_tropicalis_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------Q-----VVGVAQAINKKSGS---NG-TFTD-QDEKDF--------------------------
--------------------------------------------------------------------------------
---AAYLAFCGIVLHNAQ-LYETSL------------LENRRN---QVLLDLATLIFE---------------EQQSLEV
ILKKIAAT-ILSFMQAQRCTIFIVDEDS-----PDTFSSVFHMESD----------------------------------
--ELEESADAVK-REYDVS---------------------------KMNYMYAQYVANTMEAINIPDICKDTRFPWTNGN
------------------EEKNFKHIQS---LLCSPIKNAKKN---KVIG-VCQLVNKVDENS-------GKIKAFNKND
EQFLEAFAIFCGLGIQNTQMFEVVERAMAKQMVTLE--ILSYHASAAEEETMELQVTAGAIVPSAQS----------LK-
-------------LTEFYFSDFELS-DMETTLATSRMFTDLNLVQTF-------------------------------QM
KYEKTLCRWILSVKKN-YRKNVAYHNWRHAFNTAQCMFAALRT---GKIQGKLNDLEILALMIATLSHDLDHRGVNNSFI
QR--SEHPLAQLYCHS--IMENHHFDQCLMILN---SQGNQILSGLSVQDYKTVLKMIKQAILATDLALYIKR---RSDF
FELVN---------KKKFKWD-----------------DPSQK--------------------ELFLAMLMTACDLSAIT
KPWPVQQR---IAELVASEFYDQGDKERRELNIEPID--LMNREKKDKIPSMQ-VGFIDAVCLELYEALTQISESCYP--
------------------------------------------------------------------LLDGCQRNRQMWQI
LAEQQEKNL-----------------------------------------------------------------------
----------VNGAKSQPEVKCNMD-------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Danio_rerio_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MEVYPSDSERMMEAWLDDNLEFAHSYFVRKASREMVNAWFAERVHSIQPSRE---------------------
-------------PSKAVPEPVTAVHSLGPT-----------DVVPSSSPAPSTPTRKISASEFDRPLRPIVVKDAEGSF
TFLS----DTER-VQMPLPPSQRPGSDNGTD-------------------------------------------------
-------------------------------------EGG--GIRDRGNGDRCARLLELVR-DVSS---HLDLTALCHKI
FLHTHELIAADRYSLFLVGEDSSN--------------------------------RKFLVSRLFDVAEGSTLEESSNS-
----------GIRLEWN--KGIVGYVAATGQPLNIKNAYEDS--------RFN--------------------AEVDQIT
GYKTQSILCLPIKNHRDE-----VVGVAQAINKKCGE---NS-TFTE-QDEKDF--------------------------
--------------------------------------------------------------------------------
---SSYLAFSGIVLHNAQ-LYETSQ------------LENRRN---QVLLDLASLIFE---------------EQQSLEV
LLRKTVAT-ILSFMQAQECTVFISDRET-----ANTFASVFHMEYE----------------------------------
--EIAGSTDFPN-RECDVN---------------------------KINYMYAQYVKNTMETLNITDTTKDQLFSWTSED
P-----------------QSTNCQ-IKS---LLCTPIRNGKKD---KVIG-VCQLVNKMDEAS-------GEVKAFNRND
EQFLEAFAVFCGLGIQNTQMYEAVERAMAKQEVTLE--VLSYHASAAEEETRALQVTAAATIPSAQS----------LR-
-------------LMDYSFSDFDLT-DAETTQATIRMFVDLKLVQNF-------------------------------QI
KYK-SLCQWILSVKKN-YRKNVVYHNWRHAFNTSQCMFAVLKS---GRVQNNLSDLETLALMIATLSHDLDHRGVNNSYI
KR--SDHPLAQLYCHS--TMEHHHFDQCLMILN---SPGNQILSGLSLDEYKATLKMIEKAILATDLAVYMKK---RTEF
FELAK---------NSQFEWE-----------------DDCHR--------------------DLLRSMLMTACDISAIT
KPWPVQKK---IAELVATEFFEQGDKERRELNIEPID--LMNREKQDKIPSMQ-VSFIDAICTQLYEALTGISEFCSP--
------------------------------------------------------------------LLEGCRKNRQNWKI
LAEQGEEAA-----------------------------------------------------------------------
----------LLNGEL----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Takifugu_rubripes_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------ESERMEAWLDDHLEFTRSYFIRKASREMVNAWFAERVHSIHPSAP---------------------
-------------KEN-PPQHPRTQQSSADS------------AVTAPSPVPGTPTRKISASEFDRPLRPIVVKDAEGSL
TFLS----DADR-ETVPVR-AAAMGEGGGVH-------------------------------------------------
-------------------------------------VGGCDEAGSWCGRDRCARLLELVK-EVSS---HLDVTALCHKI
FLHINELIAADRYSLFLVGEDSSN--------------------------------RKFLVSRLFDVAEGSTVEESSSS-
----------CIRLEWN--KGIVGHVAATGQPLNIKNAYEDS--------RFN--------------------AEVDLIT
GYKTHSILCLPIKNHRDE-----VVGVAQAINKKSGD---DA-AFTD-QDEKDF--------------------------
--------------------------------------------------------------------------------
---SAYLAFSGIVLHNAQ-LYETSQ------------LENRRN---QVLLDLASLIFE---------------EQQCLKV
LLRKFAGT-ILSFMQAQACTVFIADEDS-----MNSFSSVFHMEYE----------------------------------
--ELGEVLDVPK-RDCDVS---------------------------QINYMYAQYVKNTMQTLNIADVTKDQRFPWTGEN
P-----------------DHTNDQ-IKS---LLCTPIRNGKKD---KVIG-VCQLVNKMDEAS-------DSVKAFNRND
EQFLEAFAIFCGLGIQNTQMYETVERAMAKQEVTLE--VLSYHATASEEESRELQVTVVATVPSAQS----------LR-
-------------LLDFSFSDFELS-DTETTLATIRMFVDLNLVQNF-------------------------------QM
KYM-NLCRWVLSVKKN-YRKSVAYHNWRHAFNTAQSMFALLKS---GRLQNNLNDLEVLALMIATLSHDLDHRGVNNSYI
QR--SDHPLAQLYCHS--TMEHHHFDHCLMILN---SPGNQILSSLSLDEYKSTLKMIERAILATDLALYMKR---RGEF
FELTK---------NSQFVWE-----------------DEQHR--------------------DLLRSMLMTACDISAIT
KPWPVQQR---IAELVATEFFEQGDKERRELNIEPSD--LMNREKKDKIPSMQ-VSFIDAICTQLYETLAGMSEYCSP--
------------------------------------------------------------------LLEGCQKNRQQWKH
LAEECEKG------------------------------------------------------------------------
----------LVNG------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Oryzias_latipes_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----SLCQWILSVKKN-YRKSVAYHNWRHAFNTAQCMFALLKS---GRLQNNLSDLEILALMIATLSHDLDHRGVNNSYI
QR--SEHPLAQLYCHS--TMEHHHFDQCLMILN---TPGNQILSGLSLDEYKATLKMIEKAILATDLALYMKK---REDF
FELTK---------NNQFVWV-----------------DEHHR--------------------DLLRSMLMTACDISAIT
KPWPVQKR---VAELVATEFFEQGDKERRELNIEPTD--LMNREKRDKIPSMQ-VSFIDAICIQLYETLAGLLEHCSP--
------------------------------------------------------------------LLEGCQKNRQHWKR
LAEDCEK-------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Ciona_intestinalis_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------ESVLLLELAREISDTD----DQDKFCFQA
LRHVVSIVNAEKCSLFWMRDSAKGDSK-------------------------------ELASRLWNITPKSTFDDVVCD-
---------SKNELVVPVGVGIAGLVAETKEAVIVSNVYE-HPNFN---------------------------KTIDEKT
GFESRDLLCQPLVLKREDK----VVGVVEVVNKKNKEP------FTTEDAQVLE--------------------------
--------------------------------------------------------------------------------
----HFLVLCNLAIQNCRGAAQITR------------LQQAAT---VSFLWQVN----ILFVG-----------LSYYRI
RFHKEVVMQISDLIQCERYTLAIALIDNCNIEGCLQFAKSYDLLLQKPKASMFDDEDQPIV------------------K
TVEVNNIAGYIFIYKKKQQSITN-----------------GIADVLRFLSMHSTLTAANCTKTLLNDICFIFMFEECKLL
DDAK-----------------KEFSLKS---ALCVAFYDGTDR-----LLGVLHLGNKK-------------KKGFDEND
EAVIQSVRPYIMNGLLFANGFNSIVINKAKTDVAED--TVRFHIRPWQDEVDRVVVSLAVYGNRKWSLIIMDAAFFSQNE
PIP-EGEKYN---LYQFTFSDLLMS-DDETVMGAMRMFLDLDAFNLF-------------------------------HI
RQE-TMLRWLITTRRC--YRPVYYHNWRHGLNVAHTMFLLLDR-MTPGIDKAFNDREKFALVVACFCHDIDHRGTNNAFL
IR--AGAPLAILYNTS--TLENHHYDTCLRISS---IDGNNIFESFTKEQFESACELMKHAILATDLALYFQR---RNTF
KKLLEKPFEERD-------FVQ----------------NNDNR--------------------MLLMSMMMTACDLSSIT
KPWEVQQK---MAKLVTSEFYDQGDQERALFGTEPMP--MMDRRKIDDLPKMQ-IGFIDGVCSMAYEMMADFCPGYAP--
------------------------------------------------------------------LRDGMRANRQSWKD
LASE----------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Ciona_savignyi_PDE5A
--------------------------------------------------------------------------------
--------------------------MATEAQLN----------------------------------------------
--------------------------------------------------------------------------------
---------------RELVEAWLDDHAEFAFDYFTRKATQTMVNTWLADRVIRIAGSDRKIS--------------S---
------------IERSPTKHDNDPTIRPPSTSGD--------------STGRKTPIRKISHEEIKPGHLPLKPMVLTDEM
GSPS----FYTPDSATSPSLTRR---------------------------------------------------------
------------------------------------------------MNNQRDMIMDLVI-DIAS---DLDVTSVSHRI
LQNVSILVDADRCSLFLMRER----------------DGEK-----------------FLVSRLFNVSKESTLEDNVVV-
--------KDEIKMKLG--QGIAGMVALTGTTLNIPDAYKDH--------RFN--------------------QSVDKKT
GYRTRSILCMPIRDGDKR-----IVGVAQVINKTEG-------AFTS-KDEKIF--------------------------
--------------------------------------------------------------------------------
---ASYLGFCGVAIHNAQ-IFEKVQ------------LENRRN---EILLDLARVLFE---------------EQSSLST
VMDTILTH-TVSLLSCERASVLLANPSQP----ENVFEHTFEHVDES---------------------------------
--TITSNLNFDKNSPQRNK--------------------------VPLNIAITSYVRQTGQIVNIENASSDQRFEFLEDT
--------------------ELGFTTRS---LLCIPIWDSFRQ----VIG-VIQLINKHHRV----------GPRFTKSD
EQILEAFAIFCGLGISNTRMYEETARLAAKQQVILE--VLSYHAVASPLETNALLT---NDIPSSKS----------LG-
-------------ILKYEFDDTTLS-DLDTVRASVRMFIDLKLVEKF-------------------------------RI
NHE-TLCRWVASVKRN-YR-PVSYHNWRHAFNVCQSCFCMVK--TGG-LDTVFSDFEKLALLVSCLSHDLDHRGTNNAFQ
AK--IEHPLARLYSTS--TMEHHHYNQCLMLLQ---SDGCEILSHLSSTEYAQVIKLIQHAILSTDLAIYFKK---RGEF
FNILR---------SENADWKG----------------NDSHR--------------------ELLRSLVITGCDIAGIT
RPWKVQKEI---AQLVAEEFFEQGDIEKTKLHQEPPD--MMNRKLKHKLPKMQ-IGFIDSICLPLYEALSDVEPGLQP--
------------------------------------------------------------------LLNGCLDNRRHWE-
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Caenorhabditis_elegans_PDE5A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------MDDASVLKYLQENPKLVEDFVVSNEISPETFKRWAVRRTMKYKN-----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------VKNGTSGGTGAWTEPDLSMKR--------------------
----------------------------------------------------------------------RVILETSDNR
--------TRILYEITQCCGQLIGTNSIELIVQNDEGAFSCRK---------------------------TENGELKLKK
VKTSKSADYIQTIVN---------AGNQTIAEIHFYTQ------LDSTEKSIVN--------------------------
--------------------------------------------------------------------------------
----AVCTWAAATNYYSELYTHKQEGSDGQDIHENIAKQRKLS---NFLLDVARSIFH---------------DIVSMDA
VIIKVMNF-AQKLVDADRASLFLVDSKNA-----QIYARIFD--------------------------------------
-VGTGDEEHVRVNSEGQK------------------------EIRFDMSKGIAGYVASTGEGLNIENAYEDERFNADVDS
K--------------------TGYTTKT---ILCMPILIRGIVIG------VVQMVNKHDG----------VFT---RQD
EDAFEIFAVYCGLALHHAKLYDKIRRSEQKYRVALE--VLAYHSVCNADEVNKLKK-IEINNRIVE--------------
----------------LETIDFNGM-RLSELEKPLYAVYMFKTLFA------------------------------DTLR
FDTEDLIRFVLTVRKN--YRRVAYHNWAHGWSVAHAMFATLM-----NSPDAFTKLEALALYVSCLCHDLDHRGKNNAYM
KT--MSTPLASIYSTS--VMERHHFNQTVTILQQ---DGHNILKSLSSEDYKKTLSLIKHCILATDLALFFSN---KAKL
NVILD---------NNTFDIN-----------------RQEHR--------------------LLTQAVMMTGCDLVASA
KPWNIQTET---VKVIFEEFYDQGDAERLSGKEP-IP--MMDRQQAHMLPQMQ-VGFMRGICMPCYDLIARIFPKNDK--
------------------------------------------------------------------MRERCEYNAKKWEE
LAEEQR-----------------------KKQEALAQQ------------------------------------------
-------NGEANETQE----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Nematostella_vectensis_PDE5A
--------------------------------------------------------------------------------
-------------------------------MINLEDAS-----------------------------------------
--------------------------------------------------------------------------------
--------------TEQKVESWLDEHPEFVQSYFARKANRSLVDSWLHSRSHARTPSGT-----------------P---
------------PP-----------------SG------------------SSTPVRKISASEFEGRGILKP--LVNVVD
GQLS----FLSPSEPSRKRSTAH---------------------------------------------------------
--------------------------------------RNRKSRLELQQLDEKEVLMELVK-DISN---DLDVQSLCHKI
LQNVSILLNADRCSLFLCQGP---------------KEGPR-----------------FLVSKVFDVNAESKLED-VQC-
--------LEEIRIPWG--TGIVGYVAETGETVNIPNAYEDA--------RFN--------------------KEIDKKT
GYTTRSILCMPIKDHDGE-----VIGVAQVINKTGKSTD---SAFTI-DDEQIF--------------------------
--------------------------------------------------------------------------------
---LKYLVFCGIGINNAE-LYERAQ------------LEIRRN---QVLLDLARTIFE---------------EQTSLHN
IVHKIMMI-TQSLLQCERCSVLLVDPTS-----KTLFAQAFD-LEAK---------------------------------
--DYLQNDDDDKTV--EVR--------------------------FPINIGITGHVATTGETLNIPDAYADERFDPTVDQ
--------------------VSGFTTKT---ILCMPIKNASGD----IIG-VVQLLNKVD------------GTPFNKND
ENLFEAFAIFCGMAIHSTVMYENVNKAMAKRKVALE--VLSYHAVSPLEEAIKLKE---EPLPPITS----------LR-
-------------LIDFAFDDMSIS-DDDTLKGCLAMLCDLKIVETF-------------------------------QI
DYL-TLCRFVLTIKKN-YR-PVMYHNWRHAFNVAQTMYAMLK--KPS-IGKYFTVIEQYALIVACLSHDLDHRGTNNSFQ
IK--SATPLAQLYSTS--TMEHHHFDQCIMIIN---SQGNEIFNTLSADEYNKIIKLLEASIIATDLALYFQR---RGDF
FKKVE---------NRELDWS-----------------DDSSK--------------------DLLRAMMMTACDLSAIT
KPWLVQKRT---AHLVAEEFFQQGDLEQEELHSTPLP--TMDRRKKDELPQMQ-VGFIDAVCLPLYKAFSQFDDNLKV--
------------------------------------------------------------------LKDGCRENRRQWQK
LAEDHK--------------------------------------------------------------------------
----------AREVSCRTRV------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Homo_sapiens_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAAC-E-DGCPPDCDS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------LRDLCQVEESTALLELVQDMQES----INMERVVFKV
LRRLCTLLQADRCSLFMYRQ--RNGVA-------------------------------ELATRLFSVQPDSVLEDCLVP-
---------PDSEIVFPLDIGVVGHVAQTKKMVNVEDVAE-CPHFS---------------------------SFADELT
DYKTKNMLATPIMNGKD------VVAVIMAVNKLNGPF------FTSEDEDVFL--------------------------
--------------------------------------------------------------------------------
----KYLNFATLYLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER
QFHKAFYT-VRAYLNCERYSVGLLDMTKE-----KEFFDVWS-VLMGESQPYSGPRTPDG-------------------R
EIVFYKVIDYVLHGKEEIK-VIP----------------TPSADHWALASGLPSYVAESGFICNIMNASADEMFKFQE-G
ALDD-----------------SGWLIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD
EVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQD--MVLYHVKCDRDEIQLILPTRARLGKEPAD-CDEDELGEILKE
ELP-GPTTFD---IYEFHFSDLECT-ELDLVKCGIQMYYELGVVRKF-------------------------------QI
PQE-VLVRFLFSISKG--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKFLLS---EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RAMF
QKIVDESKNYQDKKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--MMDRNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP--
------------------------------------------------------------------MFDRLQNNRKEWKA
LADEYEAKVKALEE-KE-EEERVAAKKVGTEICN-------GGPAP----------------------------------
-----------KSSTCCIL-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Macaca_mulatta_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAAC-E-DRCPPDCNS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------FRELCQVEESEALLELVQDMQEN----INMERVVFKV
LRRLCTLLQADRCSLFMYRQ--RNGVA-------------------------------ELATRLFSVQPDSVLEDCLVP-
---------PDSEIVFPLDIGVVGHVAQTKKMVNVKDVAEQCPHFS---------------------------SFADELT
DYKTKNILATPIMNGKD------VVAVIMAVNKLNGPF------FTSEDEDVFL--------------------------
--------------------------------------------------------------------------------
----KYLNFATLDLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER
QFHKAFYT-VRAYLNCERYSVGLLDMTKE-----KEFFDVWP-VLMGESQPYSGPRTPDG-------------------R
ELGHSPLHTHVQPGLVPLTPAHT----------------TPPADHWALASGLPSYVAESGFVSPVLSGAPTALPSLGE-G
ALDD-----------------SGWLIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD
EVLMESLTQFLGWSVMNTDTHDKMNKLENRKDIAQD--MVLYHVKCDRDEIQLILPTRARLGKEPAD-CDEDELGEILKE
ELP-GPTTFD---IYEFHFSDLECT-ELDLVKCGIQMYYELGVVRKF-------------------------------QI
PQE-VLVRFLFSISKG--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKFLLS---EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RAMF
QKIVDESKNYEDKKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--HVDQNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP--
------------------------------------------------------------------MFDRLQNNRKEWKA
LADEYEAKVKGVGR-GHTKQEGTN-RAVGTEICN-------GGPAP----------------------------------
-----------KSSTCCIL-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Mus_musculus_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MSLSEEQVRSFLDGNPTFAHQYFGKKLSPENVAGAC-E-DGWLADCGS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------LRELCQVEESAALFELVQDMQES----VNMERVVFKI
LRRLCTILHADRCSLFMYRQ--RNGIA-------------------------------ELATRLFSVQPDSLLEDCLVP-
---------PDSEIVFPLDIGIVGHVAQTKKMINVQDVAE-CPHFS---------------------------SFADELT
DYVTKNILSTPIMNGKD------VVAVIMAVNKLDGPC------FTSEDEDVFT--------------------------
--------------------------------------------------------------------------------
----KYLNFATLNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER
QFHKAFYT-VRAYLNCERYSVGLLDMTKE-----KEFFDVWP-VLMGEAQPYSGPRTPDG-------------------R
EIVFYKVIDYILHGKEDIK-VIP----------------TPPADHWALASGLPTYVAESGFICNIMNASADEMFNFQE-G
PLDD-----------------SGWVIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDDQD
EVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD--MVLYHVRCDKDEIQEILPTRDRLGKEPAD-CEEDELGKILKE
ELP-GPTKFD---IYEFHFSDLECT-ELELVKCGIQMYYELGVVRKF-------------------------------QI
PQE-VLVRFLFSVSKA--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKFLLA---EESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RTMF
QKIVDESKNYEDKKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--MMDRNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP--
------------------------------------------------------------------MFDRLQNNRKEWKA
LADEYEAKVKALEEEKKKEEDRVAAKKVGTEVCN-------GGPAP----------------------------------
-----------KSSTCCIL-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Felis_catus_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MSLSGEQVQQFLDQNPSFADEYFGKKLSPENVAGAH-E-DGQPVDCAS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------FRELCQVEESTALFELVQDMQES----VNMERVVFKI
LRRLCTILHADRCSLFMYRQ--RNGVA-------------------------------ELATRLFSVQPGSVLEDCLVP-
---------PDSEIVFPLDIGVVGHVAQTKKMVNIKDVTE-CPHFS---------------------------SFADELT
DYVTKNILATPIMNGKD------VVAVIMAVNKLDGPC------FTSEDEDVFL--------------------------
--------------------------------------------------------------------------------
----KYLNFGTLNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER
QFHKAFYT-VRAYLNCDRYSVGLLDMTKE-----KEFFDVWP-VLMGEAQPYSGPRTPDG-------------------R
EIVFYKVIDYILHGKEDIK-VIP----------------TPPADHWALASGLPTYVAESGFICNIMNAPADEMFKFQE-G
PLDD-----------------SGWTIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD
EVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD--MVLYHVRCDKDEIQLVLPTRERLGKEPAD-CEEDELGTILKE
VLP-GPNKFD---IYEFHFSDLECT-ELELVKCGIQMYYELGVVRKF-------------------------------QI
PQE-VLVRFLFSVSKG--YRRITYHNWRHGFNVAQTMFTLL---MTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKFLLS---EETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKK---RTMF
QKIVDESKNYEDRKSWVEYLSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALLVAAEFWEQGDLERTVLDQQPIP--MMDRNKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEILP--
------------------------------------------------------------------MFDRLQNNRKEWKA
LADEYEAKVKALEEEKQQQEERTTVKKGGTEICN-------GGPAP----------------------------------
-----------KSSTCCIL-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Gallus_gallus_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MSISEDDVEKFLDGNPAFAKQYFEKKLKTESCDDN----------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------ESEILFELIQDMQES----INMEKVVFKT
LRRIRSLIHADRCSLFMYRQ--RNGTP-------------------------------ELATRLFNIQEGSTLEECLVS-
---------PDCEIVYPLDLGIVGYVAQTKKTMNIKDVSE-CPQFS---------------------------SFVDELT
DYTTKSILATPILNGKD------LVAVILAINKLNGPF------FTNSDETLFL--------------------------
--------------------------------------------------------------------------------
----KYLNFASLNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER
QFHKAFYT-VRAYLNCDRYSVGLLDMTKQ-----KEFFDLWP-VLLGEVPPYSGPRTPDG-------------------R
EIVFYKVIDYILHGKEDIK-VIP----------------NPTPDHWALVTGLPTYVAESGFICNIMNAAADEMFNFQE-G
PLDE-----------------SGWTIKN---VLSMPIVNKKEE-----IVGVVTFFNRKD------------GKPFDEQD
ETLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQD--MVLYHVKCDKDEIQEILPTREKLGKEPSE-CEEEELASILKE
QLP-GPTKFE---IYEFRFSDFDCT-ELELVKCGIQMYYELGVVKKF-------------------------------QI
PQE-VLVRFVYSVSKG--YRKITYHNWRHGFNVAQTMFTLL---MTGKLKRYYTDLEAFAMVTAALCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLDFGKFLLS---EESLNICQNLNRRQHEHMIHLMDIAIIATDLALYFKK---RTMF
QKIVDESKTYDNTTAWTDYLSL----------------ETTKK--------------------EVVMAMMMTACDLSAIT
KPWEVQSK---VALLVAAEFWEQGDLEISVLQQQPIP--MMDRRKAAELPKLQ-VGFIDFVCTFVYKEFSRFHEEIQP--
------------------------------------------------------------------MLDGLLNNRNEWKT
RADEYDAKMKALEEEKKKEEEKMAAQKDGIT-CN-------GGTAP----------------------------------
-----------TSKTCSIL-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Anolis_carolinensis_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MSVNKDEVETFLDNNLDFAKQYFERKLGDKTLCATA-S-FHQCSEDGV---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------DFGGLGQNETETLFELIQDMQES----INMEKVVFKT
LKRISVLIQADCCSLFMYRQ--RNGTP-------------------------------ELATRLFNIRKDSTMEESLVA-
---------PDCEIVFPLDMGIVGYVAQNKKTVNIQNVDE-CDYFS---------------------------TFVDELT
GYTTRNVLATPIMNGKE------VVAVIMAVNKSGAQF------FSSADENLFL--------------------------
--------------------------------------------------------------------------------
----KYLNFAALNLKIYH-LSYLHN------------CETRRG---QVLLWSAN----KVFE-----------ELTDIER
QFHKAFYT-VRAYLNCDRYSVGLLDMSKQ-----KEFFDLWP-VLMGEVPPYSGPRTPDG-------------------R
EIAFYKVIDYILHGKEDIK-VIP----------------NPKPEHWALVSGLPTYVAETGFICNIMNAASDEMFAFQE-G
PVDE-----------------SGWVIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEQD
EILMESLTQFLGWSVLNTDTYDKMNKLEYRKDIAQD--MVLYHIKCDKNEIQAILPTREKLGKEVSE-CDEEELAAILKE
QLP-DPEEYE---IYHFHFSDLEWT-EFDLVKCGIQMYYELGVVKKF-------------------------------QI
PQE-VLVRFIFSVSKG--YRKITYHNWRHGFNVAQTMFTLL---MTGKLKQYYTDLEALAMVTAALCHDIDHRGTNNLYQ
MK--SQHPLAKLHGSS--ILERHHLEFGKFLLS---EESLNIYQNLNRRQFEHVNNLMDIAIIATDLALYFKK---RTMF
QKIVDESKTYDNEKEWAEYLSL----------------EATKK--------------------EIIMAMMMTACDLSGIA
KPWEVQSK---VALLVAAEFWEQGDLEISVLQQQPIP--MMDRRKAAELPKLQ-VGFIDFVCTFVYKEFSRFHPQIQP--
------------------------------------------------------------------MYERLLNNRKEWKA
LADDYDANMKALEEKRKEEEAKTVNSKGAILTCN-------GESVP----------------------------------
-----------PSSTCCII-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Danio_rerio_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MSVKKEDVEKFLDGNPDFTKTYFDKKLKPGAVASIMRV-PESKVDMDS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------FKEIVSVEEGAIFYDLITDMQEN----VNMEKVIFKI
LKRISALIHADRCSLFMYRQ--RNGIA-------------------------------ELATRLFNVNKDSELDDCVVA-
---------PDSEIVFPLDIGIVGHVAQTKKQVNVKDVTQ-DSHFS---------------------------TFVDELT
EYTTHNLLAAPIMNGKD------VVAVIMAVNKTTGPH------FTDEDMDLFL--------------------------
--------------------------------------------------------------------------------
----KYLKVGSLNLKIFH-LSYLHN------------CETRKG---QLLLWSAN----KVFE-----------ELTDIER
QFHKALYT-VRAYLNCDRYSVGLLDMTKE-----KEFFDIWP-VLMGEQPPYSGPVTPDG-------------------R
EIIFYKVIDYILHGKEDIK-VIP----------------NPTADHWALASGLPTYVAESGFICNIMNAASEEMFKFQT-E
ALDD-----------------SGWTIKN---VLSLPIVNKKEE-----IVGVATFYNRKD------------GKPFDEHD
EQLMEALTQFLGWSALNTDTYDKMNKLENRKDIAQD--MVLYHVKCRDDEIQDILKTREYFDREPRD-CEEEELLEILKK
ELP-GPKKFE---IYAFHFSDFDCT-ELQLVMCGIQMYYEVGVVKKF-------------------------------QV
PQEV-LVRFMYSVSKG--YRRITYHNWRHGFNVGQTMFTLL---TTGKLKQYYTDLEVMAMITAGFLHDIDHRGTNNLYQ
VK--SQNPLAKLHGSS--ILERHHLEFGKFLLG---EESLNIFQNLNRRQTEHVFHLIDIAIIATDLALYFKK---RTMF
QKIVDLSETYEERKKWIDFMSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALSVAAEFWEQGDLERTVLEQQPIP--MMDRNKAAELPKLQ-CGFIDFVCTFVYKEFSRFHPEIKP--
------------------------------------------------------------------MFDGILNNRMHWKE
RQEEYEAKLKAMEEAVKARQEAAAKNAANSNSTG-------GSGSK----------------------------------
--------------TCSIC-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Danio_rerio_PDE6A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MAAVDKDVAEKFLDSNPMFAKQYYDSRFRAKVVSDLLSTTKQTAVDISS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------HHELSSMEECEIIFDMVRDMQEN----LHMERAVFNL
MRHLSFMIRADRMSLFMYRQ--RNGIA-------------------------------ELATRIFNVHKDATLEECLVP-
---------PDSEIVYPLDTGIVGHVATAKKTVNVPDVTK-DSHFS---------------------------DFVDNLT
EYETKNVLATPIMNGKD------MVAVMMAVNKIGAPH------FTAQDEETLK--------------------------
--------------------------------------------------------------------------------
----KYLNFANLVLRVFH-LSYLHN------------CETRRG---QVLLWSAS----KVFE-----------ELTDIER
QFHKALYT-VRAFLNCDRYSVGLLDMTKT-----KEFFDLWP-VLMGEVPPYSGPKTPDG-------------------R
EVIFYKVIDYILHGKEDIK-VIP----------------NPPADHWALVSGLPTYVAENGLICNIMNAAQDEFFEFQK-E
PLDE-----------------SGWMIKN---VLSLPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD
ETLMESLTQFLGWSVLNTDTYDKMNKLENRKDIFQD--MVMYHVKCRKDEIQNILNTREMYDKEPDE-CEEDELEDILNE
VLP-DSEESE---IFEFHFCDFEFS-ELDLVKCGIKMYYELGVVDKF-------------------------------HI
PRE-TLVRFVYSVSKG--YRKITYHNWRHGFNVGQTMFTLL---MTGDLKRYYTDLEAMAMVTAGLCHDIDHRGTNNLYQ
MK--SGNPLAKLHGSS--ILERHHLEFGKTLLR---DEALNIYQNLNRRQHETVIHLMDIAIIATDLALYFKK---RTMF
QKIVDQSKTYDSWDSWTKYMML----------------ETTRK--------------------EIVMAMMMTACDLSAIA
KPWEIQSK---VALSVAAEFWEQGDLERTVLEQQPIP--MMDRNKAEELPKLQ-CGFIDFVCSFVYKEFSRFHVEITP--
------------------------------------------------------------------MLERLLNNRKEWNA
LKEIHEAKVAKLDEAKKAKEEAHAN-SDHKQGNSVQPAAQS---------------------------------------
-------------KTCVIS-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Gasterosteus_aculeatus_PDE6A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------MVDAAAAEQFLDANPQFAKQYYDANFRPKVVSDLLDGNRKAAMDISA---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------FHDLTAVEESEVLFDLMRDIQDN----LQMEKSVFNL
MKHLSFMMRADRMSLFMYRQ--RNGVA-------------------------------ELATRLFNVNKDSQFDDCLVP-
---------PDSEIVYPLDMGIVGHVASTKKMVNIADVSE-SAHYS---------------------------EFVDELT
EYKTKSVLAIPIMNGKD------MVAVMMALNKLDGPR------FTAKDEETLN--------------------------
--------------------------------------------------------------------------------
----KYLNFGNLILRVFH-LSYLHN------------CETRKG---QVLLWSAS----KVFE-----------ELTDIER
QFHKALYT-VRAFLNCDRYSVGLLDMTKT-----KEFFDLWP-VLMGEVPPYDGPKTPDG-------------------R
EIIFYKLIDYILHGKEDIK-VIP----------------NPPADHWVLVSGLPTYVAETGLICNIMNAGQDDFFKFQK-I
PLDD-----------------SGWTIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD
ETLMESLTQFLGWSVLNTDTYDKMNKLENRKDIFQD--MVMYHVKCRKDEIQHVLNTRERWGKEPDE-CEEEALQEILSE
VLP-DSKKCE---LFEFHFYDFHHT-ELELVKCGIKMYYELKVVDKF-------------------------------HI
PRE-TLVRFIYSLSKG--YRRITYHNWRHGFNVGQTMFTLL---MTGDLKRYFTDLECMAMVTAGLCHDIDHRGTNNLYQ
MK--SGNPLAKLHGSS--ILERHHLEFGKTLLR---DEALNIYQNLNRRQHDTVIHLMDIAIIATDLALYFKK---RTMF
QKIVDQSKTYENWNEWTKYMML----------------ETTRK--------------------EIVMAMMMTACDLSAIA
KPWEIQSK---VALSVAAEFWEQGDLERTVLEQVPIP--MMDRTKADELPKMQ-CGFIDFVCAFVYKEFSRFHVEITP--
------------------------------------------------------------------MLDRLMNNRKEWNA
LKEVHEAKMAAIEEAKKAKEEVA---AGARQGRYMFPNPPPGAAPR----------------------------------
------------SSSCSTP-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Oryzias_latipes_PDE6B
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------MGVGKEDVEKFLLENPAFAKTYFAKKLSPSSISKVSGL-PEKQIDFSQ---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------FQELSQIEESRLMYDVIKDMQEN----VNMEKVVFKI
LKRISSLIHADRCSLFMYRQ--RNGIG-------------------------------ELATRLFNVSMDSVLEDCVVQ-
---------PDSEIVYPLDLGIVGNVALTKKNVNVKNVKE-SQHFS---------------------------SFVDELT
DYETRNVLAAPILNGKD------MVAVIMALNKTTGPH------FTAEDEDLFL--------------------------
--------------------------------------------------------------------------------
----KYLKIASLNLKIFH-LSYLHN------------CETRKG---QLLLWSAN----KVFE-----------ELTDIER
QFHKALYT-VRAYLNCDRYSVGLLDMTKE-----KEFFDIWP-VLMGEQAPYAGPVTPDG-------------------R
EVIFYKVIDYILHGKEDIK-VIP----------------NPTPDHWALQSGLPTYVAESGFICNIMNAGADETFKFQT-E
ALDD-----------------SGWTIKN---VLSLPIVNKKEE-----IVGVATFYNRKD------------GKPFDDHD
EQLMEALTQFLGWSALNTDTYDKMNKLENRKDIAQD--MVLYHVKCRNDEIQNVLNTREVYGCEPAE-CEEEDLLDILKK
ELPPLIKKFE---IYEFRFSDFNCT-ELDLVKCGIQMYYEVGVVKKF-------------------------------QI
PQEV-LVRFMYSVSKG--YRKITYHNWRHGFNVGQTMFTLL---TTGALKRYYTDLEVMAMITAGFLHDIDHRGTNNLYQ
VK--SGNPLAKLHGSS--ILERHHLEFGKFLLS---DESLNIYQNLNRRQVDHVIHLTDIAIIATDLALYFKK---RTMF
QKIVDLSKTYEEEKKWVDFMSL----------------ETTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALSVAAEFWEQGDLERTVLEQQPIP--MMDRNKAAELPKLQ-CGFIDFVCTFVYKEFSRFHPQIQP--
------------------------------------------------------------------MLDGILNNRKEWNA
RKEEYEAKLKAIEEEMAAKEAAKAAKAA-QNNSS-------GGGSK----------------------------------
--------------TCSVC-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Homo_sapiens_PDE6A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGA-KEAAVDFSN---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------YHSPSSMEESEIIFDLLRDFQEN----LQTEKCIFNV
MKKLCFLLQADRMSLFMYRT--RNGIA-------------------------------ELATRLFNVHKDAVLEDCLVM-
---------PDQEIVFPLDMGIVGHVAHSKKIANVPNTEE-DEHFC---------------------------DFVDILT
EYKTKNILASPIMNGKD------VVAIIMAVNKVDGSH------FTKRDEEILL--------------------------
--------------------------------------------------------------------------------
----KYLNFANLIMKVYH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER
QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEVPPYSGPRTPDG-------------------R
EINFYKVIDYILHGKEDIK-VIP----------------NPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQK-E
PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD
ETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQD--IVKYHVKCDNEEIQKILKTREVYGKEPWE-CEEEELAEILQA
ELP-DADKYE---INKFHFSDLPLT-ELELVKCGIQMYYELKVVDKF-------------------------------HI
PQE-ALVRFMYSLSKG--YRKITYHNWRHGFNVGQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF
QKIVDQSKTYESEQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSQ---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHEEITP--
------------------------------------------------------------------MLDGITNNRKEWKA
LADEYDAKMKVQEEKKQKQQSAKSAAAGNQPGG--NP-SPGGATTS----------------------------------
-------------KSCCIQ-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Macaca_mulatta_PDE6A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKVISDLLGA-KEAAVDFSN---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------YHSPSSVEESEIIFDLLRDFQEN----LQTEKCIFNV
MKKLCFLLQADRMSLFMYRT--RNGIA-------------------------------ELATRLFNVHKDAVLEDCLVM-
---------PDQEIVFPLDMGVVGHVAHSKKIANVPNTEE-DEHFC---------------------------DFVDILT
EYKTKNILASPIMNGKD------VVAIIMAVNKVDGSH------FTKRDEEILL--------------------------
--------------------------------------------------------------------------------
----KYLNFANLIMKVYH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER
QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEVPPYSGPRTPDG-------------------R
EINFYKVIDYILHGKEDIK-VIP----------------NPPPDHWALVSGLPTYVAQNGLICNIMNAPAEDFFAFQK-E
PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD
ETLMESLAQFLGWSVLNPDTYESMNKLENRKDIFQD--IVKYHVKCDNEEIQKILKTREVYGKEPWE-CEEEELAEILQA
ELP-DAEKYE---INKFHFSDLPLT-ELELVKCGIQMYYELKVVDKF-------------------------------HI
PQE-ALVRFMYSLSKG--YRKITYHNWRHGFNVGQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF
QKIVDQSKTYESEQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSQ---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHKEITP--
------------------------------------------------------------------MLDGITNNRKEWKA
LADEYDAKMKVQEEEKQKQQSAKPAAAGNQLGG--NP-SPGGATTS----------------------------------
-------------KSCCIQ-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Mus_musculus_PDE6A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MGEVTAEEVEKFLDSNIGFAKQYYNFHYRGKVISDLLGA-KEAAVDFSN---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------YHDVNSVEESEIIFDLLRDVQEN----LQAEKCTFNV
MKKLCFLLRADRMSLFMYRT--RNGIA-------------------------------ELATRLFNVHKDAVLEDCLVM-
---------PDSEIVFPLDMGVVGHVAHSKKIANVPNTEE-DEHFC---------------------------DFVDNLT
EYQTKNILASPIMNGKD------VVAIIMAVNKIDEPH------FTKRDEEILL--------------------------
--------------------------------------------------------------------------------
----KYLNFVNLIMKVFH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER
QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEAPAYSGPRTPDG-------------------R
EINFYKVIDYILHGKEDIK-VIP----------------NPPADHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQK-E
PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDDMD
ETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQD--IVKYHVKCDNEEIQKILKTREVYGKEPWE-CEEEELAEILQG
ELP-DAESYE---INKFHFSDLPLT-ELELVKCGIQMYYELRVVDKF-------------------------------HI
PQE-ALVRFMYSLSKG--YRRITYHNWRHGFNVGQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF
QKIVDQSKTYESTQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHEEITP--
------------------------------------------------------------------MLDGITNNRKEWKA
LADEYEAKMKALEEEKQKQQAAKQAASGNQPGG--NP-TPGGAPAS----------------------------------
-------------KSCCIQ-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Felis_catus_PDE6A
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDMLGA-KEAAVDFSN---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------YHSLNSVEESEIIFDLLRDFQEN----LQTEKCIFNV
MKKLCFLLQADRMSLFMYRV--RNGIG-------------------------------ELATRLFNVHKDAVLDECLVV-
---------PDSEIVFPLDMGVVGHVAHSKKLANVLNTEE-DEHFC---------------------------DFVDILT
EYQTKNILASPIMNGKD------VVAVLMAVNKLNEPH------FTKRDEEILL--------------------------
--------------------------------------------------------------------------------
----KYLNFANLIMKVYH-LSYLHN------------CETRRG---QILLWSGS----KVFE-----------ELTDIER
QFHKALYT-VRAFLNCDRYSVGLLDMTKQ-----KEFFDVWP-VLMGEAPPYSGPRTPDG-------------------R
EINFYKVIDYILHGKEDIK-VIP----------------NPPPDHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQK-E
PLDE-----------------SGWMIKN---VLSMPIVNKKEE-----IVGVATFYNRKD------------GKPFDEMD
ETLMESLAQFLGWSVLNPDTYESMNKLENRKDIFQD--MVKYHVRCDNEEIQTILKTREVYGKEPWE-CEEEELAEILQG
ELP-DAEKYE---INKFHFSDLPLT-ELELVKCGIQMYYELKVVDKF-------------------------------HI
PQE-ALVRFMYSLSKG--YRRITYHNWRHGFN-GQTMFSLL---VTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQ
MK--SQNPLAKLHGSS--ILERHHLEFGKTLLR---DESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKK---RTMF
QKIVDQSKTYETEQEWTQYMML----------------EQTRK--------------------EIVMAMMMTACDLSAIT
KPWEVQSK---VALLVAAEFWEQGDLERTVLQQNPIP--MMDRNKADELPKLQ-VGFIDFVCTFVYKEFSRFHEEITP--
------------------------------------------------------------------MLDGITNNRKEWKA
LADEYDAKMKALEEEKQKQQAGVQAAAGNQPGG--NPGSAGGAPAS----------------------------------
-------------KSCCIQ-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Homo_sapiens_PDE6C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------FSELTQVEESALCLELLWTVQEE---GGTPEQGVHRA
LQRLAHLLQADRCSMFLCRS--RNGIP-------------------------------EVASRLLDVTPTSKFEDNLVG-
---------PDKEVVFPLDIGIVGWAAHTKKTHNVPDVKK-NSHFS---------------------------DFMDKQT
GYVTKNLLATPIVVGKE------VLAVIMAVNKVNASE------FSKQDEEVFS--------------------------
--------------------------------------------------------------------------------
----KYLNFVSIILRLHH-TSYMYN------------IESRRS---QILMWSAN----KVFE-----------ELTDVER
QFHKALYT-VRSYLNCERYSIGLLDMTKE-----KEFYDEWP-IKLGEVEPYKGPKTPDG-------------------R
EVNFYKIIDYILHGKEEIK-VIP----------------TPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQK-G
PVDE-----------------TGWVIKN---VLSLPIVNKKED-----IVGVATFYNRKD------------GKPFDEHD
EYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQE--MLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKE
DLP-DPRSAE---LYEFRFSDFPLT-EHGLIKCGIRLFFEINVVEKF-------------------------------KV
PVE-VLTRWMYTVRKG--YRAVTYHNWRHGFNVGQTMFTLL---MTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQ
MK--STSPLARLHGSS--ILERHHLEYSKTLLQ---DESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKK---RTMF
QKIVDACEQMQTEEEAIKYVTV----------------DPTKK--------------------EIIMAMMMTACDLSAIT
KPWEVQSQ---VALMVANEFWEQGDLERTVLQQQPIP--MMDRNKRDELPKLQ-VGFIDFVCTFVYKEFSRFHKEITP--
------------------------------------------------------------------MLSGLQNNRVEWKS
LADEYDAKMKVIEEEAKKQEGG--AEKAAED--------SGGG-DD----------------------------------
----------KKSKTCLML-------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------
>Macaca_mulatta_PDE6C
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------MGEINQDAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------FSELTQVEESALCLELLWTVQEE---GGTPEQGVHRA
LQRLAHLLQADRCSMFLCRS--RNGIP-------------------------------EVASRLLDVTPTSNFDDNLVG-
---------PDKEVVFPLDIGIVGWAAHTKKTHNVPDVKK-NSHFS---------------------------DFMDKQT
GYVTKNLLATPIVMGKE------VLAVIMAVNKVNASE------FSKQDEEVFS--------------------------
--------------------------------------------------------------------------------
----KYLNFVSVILKLHH-TSYMYN------------IESRRS--