>Homo_sapiens_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESEDEE
EEDVKLLSISGKRSAPGGGSKVPQ-KKVKLAADE-DDDD-DDEEDDDEDDDDDDFDD----------E---EAEEKAP--
-VKKSIRDTPAKNAQKSNQNGKDSKPSS---TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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-----------------------------------------------------------------
>Macaca_mulatta_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESEDEE
EEDVKLLSISGKRSAPGGGSKVPQ-KKVKLADLK-YDCI-DDELDDNENAKRCRFVD----------Y---SMQEKAP--
-VKKSIRDTPAKNAQKSNQNGKDSKPSS---TPTSYGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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-----------------------------------------------------------------
>Mus_musculus_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESEDED
EEDVKLLGMSGKRSAPGGGNKVPQ-KKVKLDEDD---EDDDEDDEDDEDDDDDDFDE----------E---ETEEKVP--
-VKKSVRDTPAKNAQKSNQNGKDLKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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-----------------------------------------------------------------
>Rattus_norvegicus_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESEDED
EEDVKLLGMSGKRSAPGGGNKVPQ-KKVKLDEDD---DEDDEDDEDDEDDDDDDFDE----------E---ETEEKVP--
-VKKSVRDTPAKNAQKSNQNGKDLKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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-----------------------------------------------------------------
>Canis_familiaris_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESEDEE
EEDVKLLSISGKRSAPGSGSKVPQ-KKVKLAADE-DDDDDDDDDDDDEDDDDDDFDD----------E---EAEEKAP--
-VKKSIRDTPAKNAQKSNQNGKDSKPS----TPRTKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
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>Bos_taurus_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADR-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHVVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESEEEE
EEEVKLLSISGKRSAPGSGSKVPQ-KKVKLAADEDEDDDDDDDDDDDEDDDDDDFD-----------E---EVEEKAP--
-VKKSVRDTPAKNAQKSNQNGKDSKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
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-----------------------------------------------------------------
>Equus_caballus_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESEDEE
EEDVKLLSISGKRSAPGSGSKVPQ-KKVKLAADE-DDDDEDDDEDDDEDDDDDDFDE----------E---EAEEKAP--
-VKKSIRDTPAKNAQKSNQNGKDSKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
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>Loxodonta_africana_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMD----------MSPLRPQNYLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAM-----------------------NYEGSPIKVTLATLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVAVEED----AESDDEE
DEDVKLLSMSGKRSAPAAGNKVPQ-KKVKLAADE-DDDEEDDDDDDDEDDDDDDFDD----------E---ETEEKVP--
-VKKSVRDTPAKNAQKSNQNGKDSKPS----TPRSKGQES-FKKQ-EKTPKTPKGPSSVEDIKAKMQASIEKGGSLPKVE
AKFINYVKNCFRMTDQEAIQDLWQWRKSL---------------------------------------------------
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>Monodelphis_domestica_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMEMD----------MSPLRPQNFLFG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHIVEAEAL-----------------------NYEGNPIKVTLASLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHVSGQHLVALEED----AESDDEE
EDDMKLLNMSGKRSAPGVGSKVPQ-KKVKLSEED---EEDDEEDDDDEDDDDDDFED----------E---ESEEKTPP-
-VKKSVRDTAAKNAQKSNQNGKDSKPS----TPKAKGQDS-FKKQ-DKTPKTPKGPTSLEDIKAKMQASIEKGGSLPKVE
GKFINYVKNCFRMSDQEL--------------------------------------------------------------
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--------------------------------------------------------------------------------
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-----------------------------------------------------------------
>Ornithorhynchus_anatinus_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------HYLAG-------------------------------------CELKADK-DYHF
KVD-NDEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDELHVIEAEAL-----------------------NYEGSPIKVTLASLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VHVSGQHLVALEED----AVSDDDE
EEEVKLGNLSGKRPAPGVVPKVPQ-KKAKLAELAVTDGAHHQPNDTLDEDEDDDFE----------------EEEKTP--
-AKKSARDTPAKNAQKSNQNGKDSKPS----TPKSKGSES-FKKQQEKSPRTPKGPLTVDDVKAKMQATMEKGGALPKVE
GKFINYVKNCFRMSDQEAIQDLWLWRKSL---------------------------------------------------
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>Gallus_gallus_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------LAG-------------------------------------CELKAEK-EYQF
KVD-DEEN----------------EHQLSLR-------------------------------------------------
---------TVTLGAGAKDELHVVEAEAL-----------------------DYEGNPTKVVLASLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVVLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VYVSGQHLVALEEE----PESEDE-
EEDTKIGNASTKRPASGGGAKTPQ-KKPKLSEDDEDDDEDEDDDEDDEDDLDD--------------D---EEEIKTP--
-MKKPAREPAGKNMQKAKQNGKDSKPST--PASKTKTPDS--KKDKSLTPKTPKVPLSLEEIKAKMQASVDKGCSLPKLE
PKFANYVKNCFRTEDQKVIQALWQWRQTL---------------------------------------------------
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-----------------------------------------------------------------
>Anolis_carolinensis_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDTDMDS----------MGSLRPQTFLFG-------------------------------------CELKGDK-PFHF
KVN-DEEN----------------EHQLSLR-------------------------------------------------
---------TVSLGAGAKDDLHVVEAEAL-----------------------DYEGNQITVTLASLKMSVQPT-------
---------------------------------------------------VSLGGFEITPPVTLRLK------------
------CGSGP---------------------------------------------------------------------
-------------------------------------------------------VYVSGQHLVALEEE----PESEDE-
EDD-KVQHNMAKRPAGVTLAKVPQ-KKAKLTEDDEDDDEDDEDDDEDDDDEEDDDDDME-------ED---EEEEKTP--
-VKKPARDLAVKKTQKSNQNGKDSKPTT--P--KQKTPET-HKEKKPQTPKTPKT-FTLEEIKAKMQAVVQKGTALPKAE
AKFANYVKNCYRTEDQKVIQALWQWRQTL---------------------------------------------------
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-----------------------------------------------------------------
>Xenopus_tropicalis_NPM1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MEDSMDMDS---------IAPLRPQNFLFG-------------------------------------CELKADKREYSF
KVE-DDEN----------------EHQLSLR-------------------------------------------------
---------TVSVGASAKDELHVVEAEGI-----------------------NYEGKTIKITLASLKPSVQPT-------
---------------------------------------------------VSLGGFEITPPVILRLK------------
------SGSGP---------------------------------------------------------------------
-------------------------------------------------------VYVSGQHLVALEDL----ESTDDED
EEHDVPSPKNAKRTASDAASKVPR-KKTRLEEED---EADSDEYVYKKNKNNEDFQIN-------------IYYNKRP--
-VKKTDLPTKPKAAQKLNHNGKASELPTPLKTPKTPEQKG-KQDTKPQTPKTPKTPLSFDEIKAKMQTSLEKGTVLPKVE
VKFANYVKNCFRTENQKVIQDLFKWRQSLKDSK-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
-----------------------------------------------------------------
>Danio_rerio_NPM1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------MSINTPELRLTG
PVRAKMEDNI---------KDLSRPQMYLFG-------------------------------------CSLKADKKEHKV
DLD-DDEA----------------EHQLSLK-------------------------------------------------
---------SVCLGAEAEDKFHTVEMEGL-----------------------TYDGKTTKITLAVLKPSVLPS-------
---------------------------------------------------LSLGGFEVTPPVSFRLQ------------
------SGGGP---------------------------------------------------------------------
-------------------------------------------------------VYISGQHFVSVKES-------DDED
EEEEENNTSPVKRPSNMTLAKVPQ-KKLKMDSDEDEDSDDDDDDDDDDDDDEEEDDDKQ-------EKPAVKSPVKSTQK
TPEK-KKSADKQNGSPDKKAGTSGKPQ-------TQTPQKVKDKSAAGPSGKTPSIPSLSEVKSKLTSAAKEGKPFPKTE
QKFENFARSSFKISDKQVIKDLWNFVQSLKK-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------
>Danio_rerio_NPM1_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MDLE------------QMGPQTFLYG-------------------------------------CELKAGK-DITF
NPE-DDDY----------------DHQLSVR-------------------------------------------------
---------MACVDPSTKDELNVVEIEGQ-----------------------DSEGQKVKAVLATLKPSTLPS-------
---------------------------------------------------VCLGGFEITPPVVFRLR------------
------TGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHLVIMGGDQSFDEEEE--E
EEEEETVMTSKKRPALS--TPKPS-KKMKMDEED---DDDDDEDDDDEDDDE--------------ED---ESEEESP--
--VK-EKKAPAK-PKTPTQNGKGPKPST---PAK---QTPQ-KGKKEQTPKTPQTPRTLADIKSKMMESVAKGVSLPKVQ
LKFENYVNNCFKGTDPKVVEELWKWRQTVK--------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------
>Takifugu_rubripes_NPM1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------TVCGSV
ATTVKMEDDF---------SDLSRPQIYLFG-------------------------------------CTLKSDKREFKI
DVE-DDDT----------------EQQLSLK-------------------------------------------------
---------AVCVGAEAEDNFHMVEIEGL-----------------------TYDGKSTKVPLAVLKPSIMPS-------
---------------------------------------------------MSLGGFEIMPPVTFRLQ------------
------AGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHFIRVKDG-------EEEE
EEEE-NNTSPVKRPLSLVSGKKPPSKKLKMDSDDEDDSEEDDDDYSDEDDDSDG-DVKP-------QK---KTLKKIPDS
SAKKTSKTPVKQNGPAEKPSGSSSKPQ-------MKTPAPGKDKAQAGPS-KSSSLP---EIKNKLSTAAKEGKPLPKTE
QKFENFVKSSFKITDKKVVKDLWAFVQSLKI-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------
>Tetraodon_nigroviridis_NPM1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----MEDDF---------SDLSRPQIYLFG-------------------------------------CTLKSDKREFKI
DAD-DDDT----------------EQQLSLK-------------------------------------------------
---------AMCVGPEAEDKFHMVEIEGL-----------------------TYDGKSTKVPLAALKPSIMPS-------
---------------------------------------------------MSLGGFEIMPPVTFRLQ------------
------AGSGP---------------------------------------------------------------------
-------------------------------------------------------VHISGQHFVRVKDA-------QEEE
E----NNTSPVKRPLSLS-VKKPTSKKLKMD----EDSDEEDNEDDDEDDESDE-DVKP-------QK---KELKKIPDF
SAKKTSKTPVKENGPTEKSSGLPSKPQT----KVSQTPAAEKDKAQAGPS-KSPSLP---EIKNKLSTAAKEGKPLPKTE
QKFENFVKSSFKITDKKVVKDLWTFVQSLKIEK-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
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--------------------------------------------------------------------------------
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------------------------