>Homo_sapiens_NKX2-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
SMSPK-------------------------------------------------------------------HTTPFSVS
DILSPLEESYKKVG---MEGGG----LGAPLA------------------------------------------------
----------------------------------AYRQGQAAPPTAAMQQHAVG-------------HHG--------AV
TAAYHMT---AAGVPQLSH-------------------------------------------------------------
----------------------------------------------SAVGGYCNGNLG---NMSELPPYQDTMRNSASGP
G----------WYGANP------DPRFPAISRFMGPA--------------SGMNMSG----------------------
----------------------------------------------MG-GLGSLGDVSKNMAP-LP--------------
-------------------------------------SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL
T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQQLQQ-----DSGGGGGGG-GTGCPQQQQ-
AQQQSPRRVAVPV-------------------LVKDGKPCQAG-------------------------------------
--------------------------APAPGAASLQGHAQQQAQ-HQAQAAQAAA--------AAISVGSGGAGLGAHPG
HQPGSAGQ---------------SPDLAHHA---------------ASPAALQGQVSSLSHLNSSGS-DYG-TMSCST--
-------LLYGRTW------------------------------------------------------------------
----------------------------
>Mus_musculus_NKX2-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
SMSPK-------------------------------------------------------------------HTTPFSVS
DILSPLEESYKKVG---MEGGG----LGAPLA------------------------------------------------
----------------------------------AYRQGQAAPPAAAMQQHAVG-------------HHG--------AV
TAAYHMT---AAGVPQLSH-------------------------------------------------------------
----------------------------------------------SAVGGYCNGNLG---NMSELPPYQDTMRNSASGP
G----------WYGANP------DPRFPAISRFMGPA--------------SGMNMSG----------------------
----------------------------------------------MG-GLGSLGDVSKNMAP-LP--------------
-------------------------------------SAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL
T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQQLQQ-----DSGGGGGGGGGAGCPQQQQ-
AQQQSPRRVAVPV-------------------LVKDGKPCQAG-------------------------------------
--------------------------APAPGAASLQSHAQQQAQ-QQAQAAQAAA--------AAISVGSGGAGLGAHPG
HQPGSAGQ---------------SPDLAHHA---------------ASPAGLQGQVSSLSHLNSSGS-DYG-AMSCST--
-------LLYGRTW------------------------------------------------------------------
----------------------------
>Takifugu_rubripes_NKX2-1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------TM
SMSPK-------------------------------------------------------------------HTTPFSVS
DILSPLEESYKKVS---MENNN----LGAPLT------------------------------------------------
----------------------------------SYRQPQVSQA--AMQQHHMG-------------HNG--------TV
SAAYHMT---ATGVSQLSH-------------------------------------------------------------
----------------------------------------------TAMGGYCNGNLG---NMGELPSYQDGMRGSTTAT
G----------WYGANP------DPRFSTISRFMGSS--------------SGMNMGS----------------------
----------------------------------------------MG-SLTSLADVGKGMGS-LS--------------
-------------------------------------STPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL
T---PTQVKIWFQNHRYKMKRQAKDKAS---------------------QQQMQQ-----DSGSCQ--------------
QQQ-SPRRVAVPV-------------------LVKDGKPCQGSG------------------------------------
---------------------------HTPTSSS-QNHHQQGGN-------------------VMIMSNNTSG-LGQHQN
QQVGSTGH---------------SPDLAPHS---------------SSPTSLQSQVAGLSHLNSPGA-EYGSALQCSA--
-------LLYGRTW------------------------------------------------------------------
----------------------------
>Branchiostoma_floridae_NKX2-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------ME
SISPK-------------------------------------------------------------------QTTPFSVT
DILSPLEEMYKKPMDGTMTGGYAG-TMNAAAAGM----------------------------------------------
-------------------------------GAGGYRQQVTQP----LQHQSMN-----------------------VPV
SNPYMHVP------TQLSH-------------------------------------------------------------
----------------------------------------------GMANPYCNGNVS------DLPHYNEHVRNT--AS
S----------WYGANP------DPRFS-FPRLMGGH--------------SG-GMGN----------------------
----------------------------------------------MGMSLGTIEG-PKPILP-----------------
-------------------------------------TTQRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLAQLINL
T---PTQVKIWFQNHRYKCKRQDKERQKSSTDQPSQQQQQ---QQQPQQQQQQQQQQQVSQHQAGQVQG---QAGQQNMC
AAGNSPRRVAVPV-------------------LVKDGKPCGNTP------------------------------------
--------------------------STTPVTGVTANMS-----------------------------------------
----AATP---------------QLNPQSQANI-------------IGTTVATVNVNGLNSHMSSGNYANNTMSSCSSSQ
-----YLLQQGRAW------------------------------------------------------------------
----------------------------
>Strongylocentrotus_purpuratus_NKX2-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
SYSPK-------------------------------------------------------------------QTTSFSVA
DILTPLEESFRRSML-DSPGSAF--PSVFSAAPS----------------------------------------------
-------------------------------MQSAYRSPQHSAH-QGMQVSPMN-------------MAS--------AN
NPYAHMH------VPQLSH-------------------------------------------------------------
--------------------------------------------------NYCNGSVG------ELSQHYSDHRPSAASW
Y-----------HGASS------DPRFT-ISRLMNHS--------------STMNMNMNMN-------------------
----------------------------------------------MNMNMNMNMSTLSAVGSGDLGKP-----------
-----------------------------------LLPSHRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLANLINL
T---PTQVKIWFQNHRYKMKRQTKEKNM---------------------QD---------NNTICHQ-------------
----SPRRVAVPV-------------------LVKDGKPCNGSSGG---------GGNTGGDLTDDD-------------
----------DRSLSGQVEGVSDQGVVGGPQQQQPQQQQQQGNVTQSMSSQQTAANHHASMKASPVEPSSCGIPISIPSS
DSGIGLSP---------------VSVHAHHQHP-------------MSQASLHHQASAMHSLYSPSAGAAGMTHNGAVNN
MSATAPFLLHGRTW------------------------------------------------------------------
----------------------------
>Hydra_magnipapillata_NKX2-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
DFSILP------------------------------------------------------------------VNSSFLVD
DILRRKHYENKIHQSNFSQFSVLSDEISIKTR------------------------------------------------
------------------------LSAFPIYNKGMHKNKELVNKSFQMNDKNITETERDFN-----------------KS
SISFDMTSNVEYSFGDKRMN------------------------------------------------------------
-------------------------------------------------------NRHSFQGLSCMVAEAEMYARGKRED
N------------SSDENSPKCESPSLTAKTEYHNAS-------------------------------------------
--------------------------------------------------ADAMHVTSESLIQQNLLN------------
------------------------------------IKSSRKKPRILFSQSQVMELEKKFKDQKYLSASERDQIANKLNL
T---PTQVKIWFQNKRYKCKKQTIESRTRPPPYEWLH-------------------------------------------
---FQHRNVPVLVQN-----------------NQVSSDVCLP--------------------------------------
----------------------------------------------------------------------------YCNR
PTYLPSNS---------------PVDMNYPPFYP-------------DPYNGHNHHYSNSYNTPSQTSTYPNSWPFYK--
--------------------------------------------------------------------------------
----------------------------
>Homo_sapiens_NKX2-2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MSLTN------------------------------------------------------------------TKTGFSVK
DILDLPDTN---DEEGSVAEGPEEEN------------------------------------------------------
---------------------------------EGPE---PAKRAGPLGQGALD-------------------AVQSLPL
KNPFYDSSDNPYTRWLAST-------------------------------------------------------------
----------------------------------------------------EGLQYS-LHGLAAGAPPQDSSSKSPEPS
--------------AD------ESPDNDKETPG-----------------------------------------------
----------------------------------------------------------GGGDA-----------------
--------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL
T---PTQVKIWFQNHRYKMKRARAEKGMEV--------------------------------------------------
TPLPSPRRVAVPV-------------------LVRDGKPCH---------------------------------------
----------------------------------------------------------------------------ALKA
QDLAAATF---------------QAGIPFSA---------------YSAQSLQ-HMQYNAQYSSAST---PQYPTAHP--
-------LVQAQQWT----------W------------------------------------------------------
----------------------------
>Mus_musculus_NKX2-2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MSLTN------------------------------------------------------------------TKTGFSVK
DILDLPDTN---DEDGSVAEGPEEES------------------------------------------------------
---------------------------------EGPE---PAKRAGPLGQGALD-------------------AVQSLPL
KSPFYDSSDNPYTRWLAST-------------------------------------------------------------
----------------------------------------------------EGLQYS-LHGLAASAPPQDSSSKSPEPS
--------------AD------ESPDNDKETQG-----------------------------------------------
----------------------------------------------------------GGGDA-----------------
--------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL
T---PTQVKIWFQNHRYKMKRARAEKGMEV--------------------------------------------------
TPLPSPRRVAVPV-------------------LVRDGKPCH---------------------------------------
----------------------------------------------------------------------------ALKA
QDLAAATF---------------QAGIPFSA---------------YSAQSLQ-HMQYNAQYSSAST---PQYPTAHP--
-------LVQAQQWT----------W------------------------------------------------------
----------------------------
>Danio_rerio_NKX2-2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------MLQ
NMSLTN------------------------------------------------------------------TKTGFSVK
DILDLPDTN---DEEGS-ITGTEEDT------------------------------------------------------
---------------------------------EGSE---ATKTPGVLVQSPLE-------------------NVQNLPL
KNPFYDNSDNPYTRWLATT-------------------------------------------------------------
----------------------------------------------------DSIQYS-LHGLSAN--SQDTSAKSPEPS
--------------AD------ESPDNDKETSS-----------------------------------------------
---------------------------------------------------------NG-SDS-----------------
--------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL
T---PTQVKIWFQNHRYKMKRARAEKGMEV--------------------------------------------------
THLPSPRRVAVPV-------------------LVRDGKPCH---------------------------------------
----------------------------------------------------------------------------TLKA
QDLAA-TF---------------QAGIPFSA---------------YSAQSLQ-HMQYNAHYSAATT---PQFPTAHH--
-------LVQTQQWT----------W------------------------------------------------------
----------------------------
>Takifugu_rubripes_NKX2-2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MSLTN------------------------------------------------------------------TKTGFSVK
DILDLPDTN---DEEGS-ITGAEEDT------------------------------------------------------
---------------------------------EGSE-TSTTKTAGVLVQSPLE-------------------NVQNLPL
KNPFYDSSDNPYTRWLATT-------------------------------------------------------------
----------------------------------------------------DSIQYS-LHGLSAS--SQD-SAKSPEPS
--------------ADD-----ESPDNDKETSS-----------------------------------------------
---------------------------------------------------------SGGSDS-----------------
--------------------------------------GKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRL
T---PTQVKIWFQNHRYKMKRARAEKGMEV--------------------------------------------------
THLPSPRRVAVPV-------------------LVRDGKPCH---------------------------------------
----------------------------------------------------------------------------TLKA
QDLAA-TF---------------QAGIPFSA---------------YSAQSLH-NMQYNAPYGAAAT---PQFPTAHH--
-------LVQTQQWT----------CAADINGEGSDGRSGGVRAQILATSDHKMAAEVRAWRHAAF--------------
----------------------------
>Branchiostoma_floridae_NKX2-2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------MDP
KMSLN-------------------------------------------------------------------SKTSFTVK
DILDMPEAKRQSPDTGSSVPGTMASA------------------------------------------------------
---------------------------------TSVG---SASHTGQLSQG-----------------------SSALP-
--PYYDASENPYMRWLGSA-------------------------------------------------------------
----------------------------------------------------EEMQYNSLTHIASSQSSPGSSTGAETSS
TADAKNTADKVDFDDDE-----EDEDDDGSTTGSANDGT-----------------------------------------
---------------------------------------------------GNSSSPGGQGDQ-----------------
--------------------------------------PKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLARLIRL
T---PTQVKIWFQNHRYKCKRAQKEGHMDTGL------------------------------------------------
NPLPSPRRVAVPV-------------------LVRDGKPCQPT-------------------------------------
--------------------------------------------------------------------------VTSCNG
YMKPVDSM---------------LSGMNMNMH--------------HSAMQTMQHMQQQMQPLQTMPYQYPIMPNSSL--
-------STSYGTWA----------W------------------------------------------------------
----------------------------
>Nematostella_vectensis_NKX2-2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------GNEP-----------------
--------------------------------------PKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREQLARIINL
T---PTQVKIWFQNHRYKFKKQNYEKGPLSEP--------------------------------------PP--------
--LFTPRTVPVPV-------------------LVRDGQPCH---------------------------------------
---------------------------------------------------------------------------GAS--
--------------------------------------------------MNNFAYHHAADFLHYPP-----VSTSYM--
-------PAHPYWT-----------W------------------------------------------------------
----------------------------
>Homo_sapiens_NKX2-3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------MM
LPSPVTS-------------------------------------------------------------------TPFSVK
DILNLEQ-------------------------------------------------------------------------
----------------QHQ--------------HFHGAHLQADLEHHFHSAP--------------------------CM
LAAAEGTQFSDG--------------------------------------------------------------------
-------------------------------------------------------GEEDEEDEGEKLSYLNSLAAAD---
------------GHGDSGLCPQGYVHTVLRDSCSE---------------------------------------------
---------------------------------PKEHEEEPEVVRDR---SQKSCQLKKSLETAGDCK------------
---------------------------AAEESERPKPRSRR-KPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKL
T---STQVKIWFQNRRYKCKRQRQDKSLELGAHAP---------------------------------------------
--PPPPRRVAVPV-------------------LVRDGKPCVTPSA-----------QAYGAPYS-----VGASAYSYNSF
PAYGYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPA---------------------------------GGGGGGGGTSAA
TTAMQPAC---------------SAAGGGPFVN------------VSNLGGFGSGGSAQPLHQGTA---AGAACAQGT--
-------LQGIRAW------------------------------------------------------------------
----------------------------
>Mus_musculus_NKX2-3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------MM
LPSPVTS-------------------------------------------------------------------TPFSVK
DILNLEQ-------------------------------------------------------------------------
----------------QRH---------------FHGAHLQAELEQHFHSAP--------------------------CM
LATAEGTQFSDA--------------------------------------------------------------------
-------------------------------------------------------GEEDEEEEGEKLSYLNSLAAAE---
------------GHGDSGLCPQSYVHTVLRDACSG---------------------------------------------
---------------------------------PKEQEEE--VVSER---SQKSCQLKKSLEAAGDCK------------
---------------------------TSEDGERPKPRSRR-KPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKL
T---STQVKIWFQNRRYKCKRQRQDKSLELGTHAP---------------------------------------------
--PPPPRRVAVPV-------------------LVRDGKPCVTPSA-----------QTYGSPYG-----VGAGAYSYNSF
PAYGYGNSAAAAAAAAAAAAAAAAYSGSYGCAYPTG--------------------------------GGGGGGGTASAA
TTAMQPAC---------------SATGGGSFVN------------VSNLGGFGSGGGAQPLHQGAA---AGSACTQGT--
-------LQGIRAW------------------------------------------------------------------
----------------------------
>Takifugu_rubripes_NKX2-3_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------VA
MRDPRTS-------------------------------------------------------------------TRHLLL
NILKLEQQQQ----------------------------------------------------------------------
----------------QQQHQSATXELQHRPHIQLTGSPSSQQQQQSFQTPPS-------------------------CM
LVQRDSPS------------------------------------------------------------------------
--------------------------------------------------------FSEGE---DNLAYLSALAVREED-
-------------RAEPSLSPDMYVHPGLEGAKLD---------------------------------------------
---------------------------------PTELEEQESTCLR-----PESCGLVSREEAAEGAQ------------
---------------------------GDPDRPAQKQRSRR-RPRVLFSQAQVFELERRFKQQRYLSAPEREHLATTLKL
T---SNQVKIWFQNRRYKCKRQRQDKSLEAAGQHH---------------------------------------------
--PPPPRRVAVPV-------------------LVRDGKPCLGGAQ-----------SY--TAAP-----YGSNPYGYNGY
SAYTYDS---------------PAYNSNYSCTYSS---------------------------------------------
IPALPPSS---------------TSS-AFMNMN------------LSNMSSLSGSPQPQPHQG------PAVSPCQGS--
-------LQGIRAW------------------------------------------------------------------
----------------------------
>Caenorhabditis_elegans_NKX2-3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----MS-----------------------------------------------------------------EKETPSPVL
DVKKEKNEETGIDEEK----------------SS----------------------------------------------
-------------------------------EDDCSKRSKVKSNPSKFSVNSILSPLESLVR------VQQQLLKMAASK
SGTPGTNAG-VPGAFPYGPGRLP---------------------------------------------------------
----------------------------------------------------------GNYFAGPFPGYSGAQPN-----
-----------WYNGN-------DPRFAAAAALLPCS---------------IDPVRS----------------------
-----------------------------------------------------AINHQFSMSS-----------------
-------------------------------------MSQRRKRRVLFSQAQVYELERRFKQAKYLTAPEREQLANSIRL
T---PTQVKIWFQNHRYKCKRQEKEK----------------------------------------------AMSGLGHS
EDGSSPPPD-----------------------------------------------------------------------
-----------------------------NDDDDDKYSIEMDDK-------------------------DDEE-------
----EEES---------------EKPVLKPS---------------GVFGLPYPPNAAAAAAAAAAAFNFPFAAQGPN--
-------PAYYMRW------------------------------------------------------------------
----------------------------
>Homo_sapiens_NKX2-4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
SLSPK-------------------------------------------------------------------HTTPFSVS
DILSPIEETYKKFSG-AMDGAPP--GLGAPLG------------------------------------------------
-------------------------------AAAAYRAPPPGPS--SQAATVAG-MQPSHAMAGHNAAAAAAAAAAAAAA
AATYHMP----PGVSQFPH-------------------------------------------------------------
----------------------------------------------GAMGSYCNGGLG---NMGELPAYTDGMRG---GA
ATG--------WYGANP------DPRYSSISRFMGPS--------------AGVNVAG----------------------
----------------------------------------------MG-SLTGIADAAKSLGPLHAAA------------
-----------------------------------AAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL
T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQ------EGGLGPP------------P
PPPPSPRRVAVPV-------------------LVKDGKPCQNG-------------------------------------
--------------------------ASTPTPGQAGPQPP----------------------------------------
----APTP---------------APELEELS---------------PSPPALHGPGGGLAALDAAAG-EYSGGVLGAN--
-------LLYGRTW------------------------------------------------------------------
----------------------------
>Pan_troglodytes_NKX2-4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
SLSPK-------------------------------------------------------------------HTTPFSVS
DILSPIEETYKKFSG-AMDGAPP--GLGAPLG------------------------------------------------
-------------------------------AAAAYRAPPPGPS--SQAATVAG-MQPSHAMAGHNAAAAAAAAAAAAAA
AATYHMP----PGVSQFPH-------------------------------------------------------------
----------------------------------------------GAMGGYCNGGLG---NMGELPAYTDGMRG---GA
ATG--------WYGANP------DPRYSSISRFMGPS--------------AGVNVAG----------------------
----------------------------------------------MG-SLTGIADAAKSLGPLHAAA------------
-----------------------------------AAAAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL
T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQ------EGGLGPP------------P
PPPPSPRRVAVPV-------------------LVKDGKPCQNG-------------------------------------
--------------------------ASTPTPGQAGPQPP----------------------------------------
----APTP---------------APELEELS---------------PSPPALHGPGGGLAALDAAAG-EYSGGVLGAN--
-------LLYGRTW------------------------------------------------------------------
----------------------------
>Danio_rerio_NKX2-4_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
SLSPK-------------------------------------------------------------------HTTPFSVT
DILSPIEETYKKFS--GMESTG---NLTSPLG------------------------------------------------
----------------------------------AYRQPQVSQT--GMQQHSMG---------------------HNATV
ATTYHMP----HSVSQFSH-------------------------------------------------------------
----------------------------------------------SAMGGYCNGSIA---NMGDLPSYQETMRNS--AA
ATG--------WYGANP------DPRYSTISRFMGPS--------------TGMNMTG----------------------
----------------------------------------------MG-TLTGMADTTKSIPPLH---------------
-------------------------------------AAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL
T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQ------EGNLCQQQ------------
---QSPRRVAVPV-------------------LVKDGKPCQNG-------------------------------------
--------------------------SNTPTPNQQQMQQ------------QQNG--------GGVVLPTSSNSMNQHQS
QQVNALVQ---------------AQDLEEMS---------------PSPPSLHSQMNSMGQIDTS--VDYTNNMVTSN--
-------LLYGRTW------------------------------------------------------------------
----------------------------
>Takifugu_rubripes_NKX2-4_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------IM
SLSPK-------------------------------------------------------------------HTTPFSVT
DILSPIEETYKKFS--GMDGAG---NLTSPLG------------------------------------------------
----------------------------------AYRQPQVSQT--GMQQHSMG---------------------HNATV
ATTYHMP----HGVSQFSH-------------------------------------------------------------
----------------------------------------------SAMGGYCNGSIG---NMGDLPSYQESMRNS--AA
ATG--------WYSANP------DPRFSTISRFMGPS--------------TGMNMTG----------------------
----------------------------------------------MG-GLTGMADATKSMPALH---------------
-------------------------------------AAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHL
T---PTQVKIWFQNHRYKMKRQAKDKAA---------------------QQLQQQQQQQQDGNLCQQQA-----------
---QSPRRVAVPV-------------------LVKDGKPCQNG-------------------------------------
--------------------------SSTPTSNQQQVQQSQQQS------QQQNG--------NGVLLASPTGNLSQHQN
QQQ---VN---------------ALDLEEMS---------------PSPPSLHSQLN-MAQIDTSA-VDYTSNMVTSN--
-------LLYGRTW------------------------------------------------------------------
----------------------------
>Nematostella_vectensis_NKX2-4
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
LHPTNPT-------------------------------------------------------------------APFTVR
NLLSLSEFHP----------------------------------------------------------------------
---------------------------------NYKEAGQSDCLTQMTSIHT---------------------------M
ASKLEPSTTSGLHMHDS---------------------------------------------------------------
------------------------------------------------------HNQSYLYGDTTRPMYMKSDSSQAAN-
------------SNTSTSQILDGSAQVSMDPELSS---------------------------------------------
---------------------------------KPESQDMHSDLQTS----QATSNGTELQQLTNSCNG-----------
---------------------------SMSSEVGNKPKRIRRKPRVLFSQAQVYELERRFKGQKYLSAPERDHLASLLKL
T---PNQVKIWFQNKRYKCKKQAMENKARAAGMESWYG------------------------------------------
-LPPEPRRVAVPV-------------------LVRDGETCFGREP-----------------YG-----YNMN-------
--------------------------------------------------------------------------------
-TNMNMNF---------------PPPHYMN---------------------------MYPQQGGNP---------LTN--
-------RSCPSQW------------------------------------------------------------------
----------------------------
>Homo_sapiens_NKX2-5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
FPSP--AL----------------------------------------------------------------TPTPFSVK
DILNLEQQ------------------------------------------------------------------------
----------------QRS--------------LAAAGELSARLEATLAPSS--------------------------CM
LAAFKPEAYAGP--------------------------------------------------------------------
-------------------------------------------------------EAAA-PGLPELRAELGRAPSPAKC-
-----------ASAFPA--APAFYPRAYSDPDPAK---------------------------------------------
---------------------------------DPRAEK------------KELCALQKAVELEKT--------------
---------------------------EADNAERPRARRRR-KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKL
T---STQVKIWFQNRRYKCKRQRQDQTLELVGLPPPPP------------------------------------------
--PP-ARRIAVPV-------------------LVRDGKPCLG-DS-----------APYAPAYG-----VGLNPYGYNAY
P----------------------AYPGYGGAACSPG------------------------------------YSCTAAYP
AGPSPAQP---------------ATAAANN-----------------NFVNFGVG-DLNAVQSPGI---PQSNSGVST--
-------LHGIRAW------------------------------------------------------------------
----------------------------
>Mus_musculus_NKX2-5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
FPSP--AL----------------------------------------------------------------TPTPFSVK
DILNLEQQ------------------------------------------------------------------------
----------------QRS--------------LASG-DLSARLEATLAPAS--------------------------CM
LAAFKPEAYSGP--------------------------------------------------------------------
-------------------------------------------------------EAAA-SGLAELRAEMGPAPSPPKC-
-----------SPAFPA--APTFYPGAYGDPDPAK---------------------------------------------
---------------------------------DPRADK------------KELCALQKAVELDKA--------------
---------------------------ETDGAERPRARRRR-KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKL
T---STQVKIWFQNRRYKCKRQRQDQTLELLG---PPP------------------------------------------
--PP-ARRIAVPV-------------------LVRDGKPCLG-DP-----------AAYAPAYG-----VGLNAYGYNAY
P-----------------------YPSYGGAACSPG------------------------------------YSCAA-YP
AAPPAAQP---------------PAASANS-----------------NFVNFGVG-DLNTVQSPGM---PQGNSGVST--
-------LHGIRAW------------------------------------------------------------------
----------------------------
>Danio_rerio_NKX2-5_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------------------------------------MM
LPSPVTS-------------------------------------------------------------------TPFSVK
DILKLEQQTR----------------------------------------------------------------------
----------------QLQS----------LHPASHHAQLHPELQDRFQAPSS-------------------------CF
LGGGDSP-------------------------------------------------------------------------
-------------------------------------------------------GFSDNE---EKMSFLNSLSMQDS--
-------------LVESSLSPPMFVHPALG---HV---------------------------------------------
---------------------------------DTKLE-DELEDHE-----TKSCGAILRTPECEAEV------------
---------------------------HSDTERAQRQRTRR-KPRVLFSQAQVFELERRFKQQRYLSAPEREHLASTLKL
T---STQVKIWFQNRRYKCKRQRQDKTLEMAGHHH---------------------------------------------
--PPPPRRVAVPV-------------------LVRDGKPCLTGSQ-----------SYNTTYAV-----N-PGPYTYNGY
S--SYNN---------------AAYTNPYSCTYPS---------------------------------------------
LPPLP-AN---------------TSTNALMSMS------------LNNLGTYS---QPQTSQG------TPVSACQGT--
-------LQGIRAW------------------------------------------------------------------
----------------------------
>Takifugu_rubripes_NKX2-5_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------------------LAM
FPSP---S----------------------------------------------------------------TSTPFSVK
DILNLEQS------------------------------------------------------------------------
----------------HDV--------------IVSSLGVSPRMDCCAAPTSSS--------------------SSSSCM
LARLKQEPPRDM--------------------------------------------------------------------
-------------------------------------------------------S-TTAASMFGEDPQDTTRGGRGNA-
-----------LCFPAT-----FYGKSFMEMDAVK---------------------------------------------
---------------------------------GGKSDA---FEEKR---RKEDFSLPSESLGDIK--------------
----------------------------SEDPERPKARRRR-KPRVLFSQAQVYELERRFKQQRYLSAPERDHLAGVLKL
T---PTQVKIWFQNRRYKCKRQRQDQSLEMVSLPPP--------------------------------------------
------RRVSVPV-------------------LVRDGKPCLAADT-----------ASYNPSYS----MSHINHFTYNNY
P----------------------AFSNYTSPGCNTN------------------------------------YACN--YP
AAA-TIQP---------------MQGSPNSG----------------NYVNF--G-DLNNVQN---T--FTSTNGVSS--
-------LHGIRTW------------------------------------------------------------------
----------------------------
>Amphimedon_queenslandica_NKX2-5
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------MSSGKK
KSFMICDILD----------------------------------------------------------------------
---------------------------------DIYTSDSSRPSSTELQVHPHI------------------------VH
SSSVIYTASAAPSHIEGGLV------------------------------------------------------------
----------------------------------------------------GGEGDECSPGTDSGLGDCKPEAIRPESP
T--------------------QHEPDSPSSSQ------------------------------------------------
-----------------------------------------------------SSEQGSTGAAKT---------------
---------------------------------------RKRRPRGLFSHAQIYELERRYALQKYLTAHEREQLANMLRL
T---ETQVKIWFQNRRYKNKRQQLENARLSPKSAVAACSK------------------------------TSDLFPSAIP
PPPPLHSIAAAPSDI-----------------KLPSTTPAFPVNSPLS--------------------------------
----------------------LNLTHAPPSALPIGVVATSLIT-----------------------PSGTQSPLYSITG
PPPSLP-----------------PPSDYSFRYPSGHPPPIMNIKSTPPSLPKSMYYPAVAAAYGGSVTSVNATIPSGSYV
SSICSCTTMPYQPLPRVPSPATSVTSIRSQY-------------------------------------------------
----------------------------
>Homo_sapiens_NKX2-6
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
LLSPVTS-------------------------------------------------------------------TPFSVK
DILRLERE------------------------------------------------------------------------
----------------------------------RSCPAASPHPRVRKSPEN--------------------------FQ
YLRMDAEPRGSE--------------------------------------------------------------------
-------------------------------------------------------VHNAGGGGG-DRKLDGSEPPGGPC-
-----------EAVLEMDAERMGEPQPGLNAASP----------------------------------------------
-------------------------------------------------LGGGTRVPERGVGNSGDSV------------
---------------------------RGGRSEQPKARQRR-KPRVLFSQAQVLALERRFKQQRYLSAPEREHLASALQL
T---STQVKIWFQNRRYKCKRQRQDKSLELAGHPLT--------------------------------------------
-----PRRVAVPV-------------------LVRDGKPCLGPGPG---------APAFPSPYS-----AAVSPYS----
-----------------------CYGGYSGAPYGAG--------------------------------------YGTCYA
GAPSGPAP---------------HTPLASA--------------------GFGHGGQNATPQGHLA----------AT--
-------LQGVRAW------------------------------------------------------------------
----------------------------
>Mus_musculus_NKX2-6
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
LSSPVAS-------------------------------------------------------------------TPFSVA
DILRLECQ------------------------------------------------------------------------
----------------------------------QKDSKTLSQWELHRNPVK--------------------------PR
YLRMNQESGWFE--------------------------------------------------------------------
-------------------------------------------------------SSDRAQAVP----------FRCTW-
-----------ETVLEMGSNPVGEPQTPPGTISR----------------------------------------------
-------------------------------------------------LGARNPMTDRGVGNLSGDM------------
---------------------------RRGGPVSTRTRPQR-KSRVLFSQAQVLALERRFKQQRYLTAPEREHLASALQL
T---STQVKIWFQNRRYKSKSQRQDQTLELAGHPLA--------------------------------------------
-----PRRVAVPV-------------------LVLDGKPCLDPD-----------VAAFLGPY------KATSPYS----
-----------------------CFGGYAGTPYDAS--------------------------------------YASRCT
SASAGPGP---------------LTPLASS--------------------GFSPGGQSAAPQGHLP----------AT--
-------PQGVTAW------------------------------------------------------------------
----------------------------
>Homo_sapiens_NKX2-8
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MATS-------------------------------------------------------------------GRLSFTVR
SLLDLPEQD---------AQHLPR--------------------------------------------------------
------------------------------------------------------------------------------RE
PEPRAP-QPDPCAAWLDSE-------------------------------------------------------------
------------------------------------------------------------RGHYPSSDESSLETSPPDSS
Q----------------------RPSARPASP------------------------------------------------
-----------------------------------------------------------GSDAE----------------
---------------------------------------KRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRL
T---PTQVKIWFQNHRYKLKRARAP---GAAE-------------------------------------SPDLAASAELH
AAPGLLRRVVVPV-------------------LVRDGQPCGG--------------------------------------
--------------------------------------------------------------------------GGGGEV
GTAAAQEK----------------CGAP------------------PAAACPLPGYPAFGPGS--ALGLFPAYQ-HLA--
-------SPALVSWNW----------------------------------------------------------------
----------------------------
>Mus_musculus_NKX2-8
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MATS-------------------------------------------------------------------GRLGFTVR
SLLNLPEQD---------AKPRVR--------------------------------------------------------
------------------------------------------------------------------------------RE
QQTCVP----QTAAWLESE-------------------------------------------------------------
------------------------------------------------------------CSHYLSSDESGLETSPADSS
Q----------------------LASLRRESP------------------------------------------------
-----------------------------------------------------------GSDPE----------------
---------------------------------------KRRKRRVLFSKAQTLELERRFRQQRYLSAPEREQLARLLRL
T---PTQVKIWFQNHRYKLKRGRAP---GITE-------------------------------------PSDMAASSDLH
AAPGLLRRVVVPV-------------------LVHDRPPSNN--------------------------------------
---------------------------------------------------------------------------GRGEG
TSAVPQDK----------------CSAR------------------LATACPVPGYTAFGPGS--ALGLFPAYQ-HLA--
-------PPALVSWNW----------------------------------------------------------------
----------------------------
>Takifugu_rubripes_NKX2-8_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-MAAP-------------------------------------------------------------------TKFSFSVR
SILDLPERD---------VEAAP---------------------------------------------------------
-----------------------------------------------------------------------------RSS
PLFS-CSSRSPYTAWMECD-------------------------------------------------------------
------------------------------------------------------------RSPCISSDEGGLEAS-PDST
K----------------------PDDSSLDSE------------------------------------------------
-----------------------------------------------------------PDKNK----------------
---------------------------------------KSKKRRVLFSKAQTLELERRFRQQRYLSGPEREQLARLLSL
T---PTQVKIWFQNHRYKMKRGRAEG-----------------------------------------------GLQDMEM
PQSSVLRRVVVPI-------------------LVRDGKPFHP--------------------------------------
-----------------------------------------------------------------------------CLL
DPE---KA---------------ACLPGS-----------------PAAPFPLT-YSSLQHAS--PVGLPPRYQQHFH--
-------TAAASRFAWRDFWSDSVHFNSFK--------------------------------------------------
----------------------------
>Ciona_intestinalis_NKX2-8
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
SVSPKH-----------------------------------------------------------------STTTPFSVT
DILSPLEESYGTGSVEGIVSGRREFSELYSNMES----------------------------------------------
-------------------------------GAASSAGIHVPNLGGGGSTGSISSPMTSYRQPMMGTPPHHSIHHQQMSS
ANPYQTAAG-MNGSYNLHPMPTPPQTS-----------------------------------------------------
---------------------------------------------FHAMPGSGGPTGYGNGGVPELPPYNNVQSP-----
-----------WYGAPSN----PDPRFVPSYPRLQITGY-----------GSMMPGTG----------------------
-----------------------------------------------------MDGMHKTLLP-----------------
-------------------------------------PSQRRKRRVLFSQAQVFELERRFKQQKYLSAPEREHLAQMIHL
T---PTQVKIWFQNHRYKNKRSLKDKQTQEMSVQQQQQQQQQSQTSGNAQPQHTNDLSHSNPSQLQPVAS-AVPGGTRTP
QETYSPVPTGVQA-------------------SQPGMVDGNDG-------------------------------------
--------------------HRMVHISNQNGDQSSPRHLTMSDG-SCHDSTIIESPNMQMPMPNVVQPTDTEAGLGPFSS
VIKLEEVN---------------VDSAEGSG---------------GNSGNIVPQTHYLGSTHHHDLMNVNVTTLNAV--
-------DAYQHHPHHNHIPIGNTVLNDQSILYSVYR-------------------------------------------
----------------------------
>Caenorhabditis_elegans_NKX2-8
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------MFNV
SALAAA------------------------------------------------------------------TPSIASVS
SVASPSEQHGLSTSVGVGVNDTTSRTGDG---------------------------------------------------
--------------------------------GAASSASSASAAPQQQSQSALH-------------------NKLEAKW
DTLLPTDTNLQCSTWPDSIPLLAG--------------------------------------------------------
-----------------------------------------YSATPTFSFDPCTYGSYDPSAYFASNGIAGSMYTLPDQF
PR----------SENDMLDNSNTSNGNKSDKDGIKLEDE-----------DE----------------------------
----------------------------------------------------ILEDEENDEEDDGTGK------------
--------------------------------------RKKRKRRVLFTKAQTYELERRFRSQKYLSAPEREALAMQIRL
T---PTQVKIWFQNHRYKTKKSHTDKPINAALLT-----------------------------------TMPNAFSSQST
AASFPTRAMPIPM-------------------LVRDSSARSS--------------------------------------
----------------------------------------------------------------------------DISS
TSPYTVAF---------------GSANSGYLP--------------TPSAYLPATSGYFSNGPSAAS---------SY--
-------MTNTQWWPS----------------------------------------------------------------
----------------------------
>Homo_sapiens_NKX3-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------MLRVPEPRPGEAKAEG----AAPPTPSKPLTSFLIQ
DILRDGAQRQGG-RTSSQR-------------------------------------------------------------
----------------QRD--PEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEEAE------------------------
-TLAETEP------------------------------------------------------------------------
-----------------------------------------------------------------ERHLGSYLLDSE---
--------------------------------------------------------------------------------
-----------------------------------------------------NTSGALPRLPQTP--------------
-------------------------------------KQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKL
T---ETQVKIWFQNRRYKTKRKQ--LSSELGDLEKH--------------------------------------------
---S--SLPALK--------------------------------------------------------------------
--------------------------------------------------------------------------EEAFSR
ASLVS-VY---------------NSYPYYPYLY-----------------CVGS--WSPAFW------------------
--------------------------------------------------------------------------------
----------------------------
>Mus_musculus_NKX3-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------MLRVAEPREPRVEAGGRSPWAAPPTQSKRLTSFLIQ
DILRDRAERHGG-HSGNPQHS-----------------------------------------------------------
-----------------------PDPRRDSAPEPDKAGGRGVAPEDPPSIRHSPAE------------------------
-TPTEPES------------------------------------------------------------------------
-----------------------------------------------------------------DAHFETYLLDCE---
--------------------------------------------------------------------------------
-----------------------------------------------------HNPGDLASAPQVT--------------
-------------------------------------KQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKL
T---ETQVKIWFQNRRYKTKRKQ--LSEDLGVLEKN--------------------------------------------
---SPLSLPALK--------------------------------------------------------------------
--------------------------------------------------------------------------DDSLPS
TSLVS-VY---------------TSYPYYPYLY-----------------CLGS--WHPSFW------------------
--------------------------------------------------------------------------------
----------------------------
>Danio_rerio_NKX3-1_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------SRAVQSESDN---------YQPGERGFIFT
FIGSLAAQMATSNKQLTSFF------------------------------------------------------------
-----------------------IEDILSLKEDKKDEDSCNAESDR------------D---------------------
-DSTDRQT------------------------------------------------------------------------
-----------------------------------------------------------------D------SADTC---
--------------------------------------------------------------------------------
-----------------------------------------------------RTSEGKTVSSTEMTGG-----------
-------------------------------------GGKKKRSRAAFTHLQVLELEKKFSRQRYLSAPERTHLASALHL
T---ETQVKIWFQNRRYKTKRRQ--LTTEHSKDYFQ--------------------------------------------
---KSNAAAMAAT-------------------------------------------------------------------
--------------------------------------------------------------------------EEDFFR
ASLLATVY---------------KSSPYRPYVYD----------------LHGLSMWRPAL-------------------
--------------------------------------------------------------------------------
----------------------------
>Anopheles_gambiae_NKX3-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------MSLTASTAKS----IVSTPFSIN
DILTRSRRVERHSSGESSGNEEDMQTFYHPRHHHNHYHAQHTRHTQHVRRG-----------------------------
--------------------TLEPSGSPRSTVEEGLYGKLSMSYYNNNNNNNNATTPSGFPVNGLPPALRRGSLDCFMVS
AEPVREHGEDVAARPDTGDGGGDGGNPSERI-------------------------------------------------
----------------------------------------------------------ASMLLEGARPSASVTATCYRLS
KAA----------HQRS--ESPIDMRRLAENDSDCDSSPS----------------------------------------
------------------------------------------PYTGSLGLHGGQATTLHTSEEMPS--------------
--------------------------------------ARKKRSRAAFSHAQVFELERRFAQQRYLSGPERSELAKNLRL
T---ETQVKIWFQNRRYKTKRKQIQQHEAALLSATK--------------------------------------------
---RVPVQVLVRE-------------------DGS--YGPMLAAGQPHYATGLDP-------------------------
--------------------------------------------------------------------ALLNVYRHQIQM
AYGMPGIP-----------------SMPFSYFYPSKMATVPN------GPIAPSVVLSAPSSSSSSSSNSCKPPSSHHGP
LQAASSGPLNFSTRCDSDAENVNSTGRRSPSELSGPGSDDVRSRSRMDVDVSGHCSVLSSAGEGDEDECENVEID-----
----------------------------
>Homo_sapiens_NKX3-2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MAVRGANTLTSFSIQ
AILNKKEERG---GLAAPEGRPAPG-GTAASVAA--APAVCCWRLFGERDAGALGGAEDSLLASPAGTRTAAG-------
----------------------RTAESPEGWDSDSALSEENESR--RRCADARGASGAGLAGGSLSLGQPVCEL----AA
SKDLEEEA------------------------------------------------------------------------
----------------------------------------------------------------AGRSDSEMSASVSGD-
-------------RSPRTEDDGVGPRGAHVSALCSGAG------------------------------------------
------------------------------------------GGGGSGPAGVAEEEEE-PAAPKP---------------
---------------------------------------RKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKL
T---ETQVKIWFQNRRYKTKRRQ--MAADLLASAP---------------------------------------------
----AAKKVAVKV-------------------LVRDDQRQYLP-------------------------------------
--------------------------------------------------------------------------GEVLRP
PSLLPLQP---------------S--YYYPY------------------YCLPGWALSTCAAAAGTQ-------------
--------------------------------------------------------------------------------
----------------------------
>Mus_musculus_NKX3-2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MAVRGSGTLTPFSIQ
AILNKKEERG---GLATPEGRPAPG-GTEVAVTA--APAVCCWRIFGETEAGALGGAEDSLLASPARTRTAVG-------
----------------------QSAESPGGWDSDSALSEENEGR--RRCADVPGASGTGRARVTLGLDQPGCEL----HA
AKDLEEEA------------------------------------------------------------------------
----------------------------------------------------------------PVRSDSEMSASVSGD-
-------------HSPRGEDDSVSPGGARVPGLRGAAG------------------------------------------
------------------------------------------SGASGGQAGGVEEEEE-PAAPKP---------------
---------------------------------------RKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKL
T---ETQVKIWFQNRRYKTKRRQ--MAADLLASAP---------------------------------------------
----AAKKVAVKV-------------------LVRDDQRQYLP-------------------------------------
--------------------------------------------------------------------------GEVLRP
PSLLPLQP---------------S--YYYPY------------------YCLPGWALSTCAAAAGTQ-------------
--------------------------------------------------------------------------------
----------------------------
>Danio_rerio_NKX3-2_b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------------------------------MANNRTSFSIH
NILNQGHECG---KNGSFDEEYE-----------------------GEKRTQDSGSSVPVN-------------------
----------------------RGAESAQTRISSCVLVLESLSS--DQHSCEEESTGED---------------------
-NSLERRH------------------------------------------------------------------------
----------------------------------------------------------------DHEMDQQKPQSCSFE-
-------------DS-----------------------------------------------------------------
-------------------------------------------------------------NPKS---------------
---------------------------------------SKKRSRAAFSHAQVYELERRFNLQRYLSGPERADLAGALKL
T---ETQVKIWFQNRRYKTKRRQ--MAAELATTPTT--------------------------------------------
---TLAKRVAVKV-------------------LVRNDQRQYN--------------------------------------
--------------------------------------------------------------------------TEDLPS
PSVPPLYQ---------------S-FPYYPY-----------------MFCFQPWISGNTLSGGMY--------------
--------------------------------------------------------------------------------
----------------------------
>Takifugu_rubripes_NKX3-2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------------------MAVRG-NSLMPFSIQ
AILNKKDESR---HLPDLDMCFSKT---------------ACWKIFGEMNGASRRGDDDVS-------------------
----------------------CEQTNPKNYDSDSGLSEDNDSK--IPVPCTSEKHGDP---------------------
ASDVPEES------------------------------------------------------------------------
----------------------------------------------------------------LQ-ETDHESATAENA-
-------------KSDSEPSNTTG------FISVPDSS------------------------------------------
-----------------------------------------------------TVEDKSPDQPKQ---------------
---------------------------------------RKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAASLKL
T---ETQVKIWFQNRRYKTKRRQ--MAADLMASTP---------------------------------------------
----AAKKVAVKV-------------------LVRDDQRQYSP-------------------------------------
--------------------------------------------------------------------------GELLRP
P-LLSLQP---------------S--YYYPYA-----------------YCLPAWTLS---ACAGNQ-------------
--------------------------------------------------------------------------------
----------------------------
>Drosophila_melanogaster_NKX3-2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------------MLNMESAGVSAAMAGLSKSLTTPFSIN
DILTRSNPETRRMSSVDSEPE-----------------PEKLKPSSDRER------------------------------
--------------------SISKS-PPLCCRDLGLY-KLTQ----PKEIQPSARQPSNY-------------LQYYAAA
MDNNNHH------HQATG--------------------------------------------------------------
--------------------------------------------------------------------TSNSSAADYMQR
KLA----------YFGSTLAAPLDMRRCTSNDSDCDSPP-----------------------------------------
------------------------------------------PLSSSP----SESPLSHDGSGLS---------------
---------------------------------------RKKRSRAAFSHAQVFELERRFAQQRYLSGPERSEMAKSLRL
T---ETQVKIWFQNRRYKTKRKQIQQHEAALLGASK--------------------------------------------
---RVPVQVLVRE-------------------DGSTTYAHMAAPGAGH---GLDP-------------------------
--------------------------------------------------------------------ALINIYRHQLQL
AYGGLPLP---------------QMQMPFPYFYP--QHKVP-------QPIPPPTQSSSFVTASSASSS----------P
VPIPIPG-----------AVRPQRTPCPSPN-------------GQMMSVESGAESVHSAA----EDVDENVEID-----
----------------------------
>Homo_sapiens_NKX6-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------MLAVG-AMEGTRQSA-------------------------------FLLSSPPLAAL
HSMAEMKT-PLYPAAYPPLPAGPPSSSSSSSSSSS---------------------------------------------
-------------PSPPLGTHNPGGLK-----PPATGGLSSLGSPPQQLSAA---------------------------T
PHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSA-------------------------------------------
---------------------------------------SASSASAAAAAAAAAAAAASS-PAGLLAGLPRFSSLSPPPP
PP-GLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVM-----------------------------------------
-----------------------------------------------QSP-PWRDARLACTPHQGS--------------
-------------------------------ILLDKDGK-RKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM
T---ESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETER----------------------------------------
-----LKGASENE---------------------EEDDDYNKP-------------------------------------
--------------------------------------------------------------------------LDPNSD
DEKITQLL--------------KKHKSSSG--------------GGGGLLLHASEPESSS--------------------
--------------------------------------------------------------------------------
----------------------------
>Mus_musculus_NKX6-1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------MLAVG-AMEGPRQSA-------------------------------FLLSSPPLAAL
HSMAEMKT-PLYPAAYPPLPTGPPSSSSSSSSSSS---------------------------------------------
-------------PSPPLGSHNPGGLK-----PPAAGGLSSLGSPPQQLSAA---------------------------T
PHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSA-------------------------------------------
---------------------------------------SATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPP
PP-GLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVM-----------------------------------------
-----------------------------------------------QSP-PWRDARLACTPHQGS--------------
-------------------------------ILLDKDGK-RKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM
T---ESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETER----------------------------------------
-----LKGTSENE---------------------EDDDDYNKP-------------------------------------
--------------------------------------------------------------------------LDPNSD
DEKITQLL--------------KKHKSSGGS-----------------LLLHASEAEGSS--------------------
--------------------------------------------------------------------------------
----------------------------
>Danio_rerio_NKX6-1_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------MLAVG-QMDGSRQSA-------------------------------FLLNTPPLAAL
HSMTEMKT-PLYP-AYPLSSTGPASSTSPTATSPN---------------------------------------------
--------------PGGIP-VSSPGIK-------TSSGLSA-LASAQQCAIA---------------------------T
PHGINDILSRP---------------------------------------------------------------------
--------------------------------------------S------------VACSPAGILSGLPRFSSLSPPPP
PG--LYFSPSAAA-VAVARYPKPLTELPGRTPIFWPGVM-----------------------------------------
-----------------------------------------------QSP-HWRDARFACSPHQNS--------------
-------------------------------VLLDKDGK-RKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGM
T---ESQVKVWFQNRRTKWRKRHAAEMASAKKKQDSETER----------------------------------------
-----LKGASENE