>Homo_sapiens_NIPAL1
-----------------------------------------------------------MGA--QVRLPPGEPCREGYVL
SLVCP-NSSQAWCEITNVSQLLASPVLYTDLN-------YSINNLSISANVENKYSLYVGLVLAVSSSIFIGSSFILKKK
GLLQLASKGFTRAG--QGGHSYLKEWLWWV--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF
LNEHLNIHG--------KIGCILSILGSTVMVIHAPQEEEVTSLHEMEMKLRDP--GFISFAVII--------TVISLVL
ILIVAPKKGQTNILVYISICSLIGAFSVSSVKGLGIAIKELIEWKP-----VYKHPLVFVLLAVLVL--SVTTQINYLNK
ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMTAGDIIGTLSGFFTIIIGIFLLHAFKNTDITWSELTST
AKKEAVS-------LNVNENN----YVLLEN----------------LECSAPGYNDDVTLFSRTDD-------------
-------------------------
>Pan_troglodytes_NIPAL1
-----------------------------------------------------------MGA--QVRLPPGEPCREGYVL
SLVCP-NSSQAWCEITNVSQLLASPVLYTDLN-------YSINNLSISANVENKYSLYVGLVLAVSSSIFIGSSFILKKK
GLLQLASKGFTRAG--QGGHSYLKEWLWWV--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF
LNEHLNIHG--------KIGCILSILGSTVMVIHAPQEEEVTSLHEMEMKLRDP--GFISFAVII--------TVISLVL
ILIVAPKKGQTNILVYISICSLIGAFSVSSVKGLGIAIKELIEWKP-----VYKHPLVFVLLAVLVL--SVTTQINYLNK
ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMTAGDIIGTLSGFFTIIIGIFLLHAFKNTDITWSELTST
AKKEAVS-------LNVNENN----YVLLEN----------------LECSAPGYNDDVTLFSRTDD-------------
-------------------------
>Mus_musculus_NIPAL1
-----------------------------------------------------------MGV--QLRLPPGEPCHEGYVL
SLVCS-NSSRASCEITNVSESLPYPVVYTNLN-------SSKTNFSISASVENKYNLYVGLVLAISSSVFIGSSFILKKK
GLLQLADKGITRAG--QGGHSYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF
LNERLNIHG--------KIGCILSVLGSTVMVIHAPQEGEVTSLHEMEMKLRDP--GFVSFAVII--------SVISLVL
ILIVAPKKGQTNILVYIAICSLIGAFSVSSVKGLGIAIKELLERKP-----VYKDPLFFILLTMLAL--SVTTQINYLNK
ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMKAGDIIGTLSGFFTIINGIFLLHAFKNTNITWSELMST
AKKEALS-------PNGNQNS----YVLLEN----------------ADFSASGYDDDITLFSRTNDQSSHKL-------
-------------------------
>Rattus_norvegicus_NIPAL1
-----------------------------------------------------------MGA--QLRLPPGEPCREGYVL
SLVCS-NSSQALCEITNVSQPLAYPVLYTNPN-------SSTSNFSISAGVENKYSLYVGLVLAISSSFFIGSSFILKKK
GLLQLADKGITRA--------------------------VGAGEAANFAAYAFAPATLVTPLGALSVLIS---AILSSYF
LNEHLNIHG--------KIGCILSILGSTVMVIHAPQEGEVTSLHEMEMKLRDP--GFISFAVIV--------SVISLVL
ILVVAPRKGQTNILVYISICSLIGAFSVSSVKGLGIAIKELLERKP-----VYKDPLVFILLAVLTL--SVTTQINYLNK
ALDTFNT-SLVTPIYYVFFTSMVVTCS-----AILFQEWYGMRAGDIIGTLSGFFTIINGIFLLHAFKNTNITWSELTST
AKKEVLS-------SNGSQNS----YVLLEN----------------ADCSTSGCDDDITLFSRTGDQSIHKL-------
-------------------------
>Ornithorhynchus_anatinus_NIPAL1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------G--QGGHSYLKQWLWWA--GLLS---MGLGEAANFAAYAFAPATLVTPLGALSVLVS---AILSSYF
LHERLNVHG--------KLGCVLSLLGSTVMVIHAPEEEEVTSLADMEAKLRDP--GFVCFAVVV--------VVTSLVL
ILVVAPRKGQNNILVYVSICSAIGAFSVSSVKGLGIAMKDLMEQKP-----VYRDPLVFVLLATLVL--SISTQINYLNK
ALDTFNT-SLVTPIYYVGFTSMVLTCS-----IILFKEWHDLGARDVLGTLSGFGTIIGGIFLLHAFRGVPPSWSQLSAP
VRKGVASA------LSAGEDG----HALLEH----------------VECSRLGCDDDLTLFSRVGG-------------
-------------------------
>Homo_sapiens_NIPAL2
--------------------------------------------------------------------------------
-MAAVAPAGPGDS-ASAALDELSLNFTYGAPGAGNGSLSG--------DWYRRNQIHLFGVLLAILGNLVISISLNIQKY
SHLQL--------AQQEHPRPYFKSVLWWG--GVLL---MAVGETGNFAAYGFAPITLIAPLGCVSVTG---SAIISVTF
LKDNLRASDLLG--------TTLAFAGTYLLVNFAPNITQAISARTVQYYLVGWQ--FLIYVILE--------ILIFCIL
LYFYKRK-GMKHMVILLTLVAILAS--LTVISVKAVSGMITFSVMD----KMQLTYPIF-YIMFIIMIASCVFQVKFLNQ
ATKLYNT-TTVVPVNHIFFTISAIIA-----GIIFYQEFLGAPFLTVFIYLFGCFLSFLGVFLVTRNR-EKEHLQQSYID
FGNIP-------GKQMLDKIQPDSHSLSYGTLPDGSDSTKSQSGEKKEV-------------------------------
-------------------------
>Pan_troglodytes_NIPAL2
--------------------------------------------------------------------------------
-MAVLAPAGPGDA-ASAALDELSLNFTYGAPGAGNGSLSG--------DWYRRNQIHLFGVLLAILGNLVISISLNIQKY
SHLQL--------AQQEQPRPYFKSVLWWG--GVLL---MAVGETGNFAAYGFAPITLIAPLGCVSVTG---SAIISVTF
LKDNLRASDLLG--------TTLAFAGTYLLVNFAPNITQAISARTVQYYLVGWQ--FLIYVISE--------ILIFCIL
LYFYKRK-GMKHMVILLTLVAILAS--LTVISVKAVSGMITFSMMD----KMQLTYPIF-YIMFIIMIASCVFQVKFLNQ
ATKLYNT-TTVVPVNHIFFTISAIIA-----GIIFYQEFLGAAFLTVFIYLFGCFLSFLGVFLVTRNR-EKEHLQQSYID
FGNIP-------GKQMLDKIQPDSHSLSYGTLPDGSDSTKSQSGEKKEV-------------------------------
-------------------------
>Mus_musculus_NIPAL2
--------------------------------------------------------------------------------
-MAAPARTAPEDD-ASAVLDELSRNFTYWAPGPGNGSLSS--------AWYRRNQIHLFGVLLAILGNLVISISLNIQKY
SHLHL--------AQKEHPKPYFKSVLWLS--GVLL---TALGETGNFAAYGVAPITLIAPLGCMSVTG---SAIISVIF
LKENLRASDLLG--------MTLAFAGTYLLVNFAPNVTQAISARTVQYYFVGWQ--FLVYVILE--------ILVFCIL
LYFHKRK-GMKHIVVLLTLVALLAS--LTVISVKAVSGMITLSVTG----KMQLTYAIF-YIMLVIMIASCVFQVKFLNQ
ATELYTM-TTVVPVNHVFFTTSAIIA-----GIIFYQEFLGAAFLTVFIYLFGCFLSFLGVFLVTRNR-EKEHLQQSFVD
LGDIP-------GKQMLDKVQPDSNGLSYGTLPDGGDSTRGQCGEKKES-------------------------------
-------------------------
>Rattus_norvegicus_NIPAL2
--------------------------------------------------------------------------------
-MASPAPTGPQDD-ASAVLDELSRNFTYWAPGPSNGSLSS--------AWYHRNQIHLFGVLLAILGNLVISISLNIQKY
SHLHL--------AQKEHPKPYFKSVLWLS--GVLL---MAIGETGNFAAYGVAPITLIAPLGCVSVTG---SAVISVIF
LKENLRASDLLG--------MTLAFAGTYLLVNFAPNITQAISARTIQYYFVGWQ--FLVYMILE--------ILVFCIL
LYFHKRK-GKKHIVILLTLVALLAS--LTVISVKAVSGMITLSVTG----KMQLTYAIF-YIMLVIMIASCVFQVKFLNQ
ATELYTM-TTVVPVNHVFFTTSAIIA-----GIIFYQEFLGAAFLTVFIYLFGCFLSFLGVFLVTRNR-EREYLQQSFID
FGNIP-------GKQMLDKIQPDSNGLSYGSLPDGGDSTRGQRAEKKEA-------------------------------
-------------------------
>Pteropus_vampyrus_NIPAL2
--------------------------------------------------------------------------------
-MATLALADPQDA-AAAALDELPRNFTYGALSSGNGSLSG--------AWYRRNQIHLFGVLLAILGNLVISISLNIQKY
SHLQS--------AHREHPRPFFRSVLWWV--GLVL---MAVGETGNFAAYGFAPITLIAPLGCMSVTG---SAIISVMF
LKENLRASDLLG--------MTLAFAGTYLLVSFAPNITQAVSARTIQYYFVGWQ--FLIYVILE--------ILIFCIL
LYFHKRK-GMKHIVILLTLAALLAS--LTVISVKAVSGMITFSVTD----KMQLTYPIF-YIMFIIMIASCVFQVKFLNQ
ATKLYDT-TMVVPVNHIFFTTSAIIA-----GIIFYKEFLGEAFLTIFIYLFGCFLSFLGVFLVTRNR-EKEHLPQSYID
FGNIP-------DTTRGNQLWRETN--------VG-NTTRFKQ-------------------------------------
-------------------------
>Monodelphis_domestica_NIPAL2
--------------------------------------------------------------------------------
-MASLQQRGSGDEGFSETLDELDWNFTYGGQGVGNGSLSS--------FWYNRNQAHLFGVLLAVTGNLIISISLNIQKY
SHLKL--------AHQGSQNPYFRSILWWC--GSLL---MVIGETGNCVGYGLAPVTLIAPLGCLSVAG---SAIMSVTF
LRGNLRSSDLLG--------VTLAFAGTYLLVAFAPNITQDITAKKVRYYFVGWQ--FLAYVILE--------ILIFCIL
LYFYKRK-DMKHIVILLTLVALLAS--MTVISVKAVSSMIILSVKG----EMQLTYPIF-YIMFIIMIASCIFQVKFLNQ
AMKLYDM-TTVVSLNHIFFSTSAIVA-----GIIFYQEFHGATLLGALMYLFGCFLSFFGVVLVTRNR-EKKHLQQSYID
IGEIP-------GKQMLDKIQPESNGQSYGTLPDESNPMKSPGGDKKDI-------------------------------
-------------------------
>Takifugu_rubripes_NIPAL2_a
--------------------------------------------------------------------------------
---------------------------------------------------------LLGIIISICGNVLISISLNVQKY
THLRQ--------AERG-SKPYYTSPVWWF--GVVL---MGVGEMGNFAAYGFAPATLIAPLGCVSVIA---SAIISVVF
LKETVRASDIFVLCSLSATGGTLAITGTYLLVTFAPHSSVHITAHLVQYYMFSWQ--FLLYLLIE--------VVVFSVL
LYLYKRR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITESIKG----QLQFIYPIF-YVMLVVMFASCGFQIKFLNE
AMKVFDA-TEVVPINFVFFTASAIIA-----GVVFYQEFQGLALLNIFMFLFGCLLCFLGVFLIARNRPKSKEPDLNFIR
MEKIP-------RRSHTDKVQPEAKTLAYGAL------------------------------------------------
-------------------------
>Tetraodon_nigroviridis_NIPAL2_a
--------------------------------------------------------------------------------
---------------------MEINTSSQHALLWDALRAD--------VMENPLQMYLLGIIISVCGNVLISISLNIQKY
THLRQ--------AERG-SKPYYTSGVWWF--GVIL---MGVGELGNFAAYGFAPATLIAPLGCVSVIA---SAIISVVF
LKETVRASDIL--------GGTLAITGTYLLVTFAPHNSVHITAHLVQYYMLCWQ--FLLYLFIE--------VVVFCVL
LYLYTRR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITETIKG----QLQFIYPIF-YVMLVVMFASCGFQIKFLNE
AMKMFDA-TEVVPINFVFFTASAIIA-----GVVFYQEFQGLALLNIFMFLFGCLLSFLGVFLIARNRPKRKEPDRNFIR
MEKIP-------GRSHTDKVQPEATTLTYGSLAAKLMCTSAVQTDAS---------------------------------
-------------------------
>Gasterosteus_aculeatus_NIPAL2_a
--------------------------------------------------------------------------------
-------------------------------------------------------TYLLGIIISICGNILISISLNIQKY
AHVRQ--------SQRD-SKPYYTSAVWWC--GVAL---MGIGELGNFAAYGFAPASLIAPLGSVSVIA---SAVISVIF
LKETVRVSDVV--------GGSLAITGTYVLVTFAPHTITHITAHLIQYYIVSWY--FVLYLSLE--------VLLFCIL
LYVYKKR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITETIKG----QLQFIYPIF-YVMLVIMIASCAFQIKFLNQ
AMKMFDA-TEVVPINFVFFTASAIVA-----GIVFYQEFEGLALLNIFMFLFGCLLSFLGVFLIARNRPKIKQQDPDFIA
LDKIP-------SRSHTDKVQPEANTQTYGSLAA----------------------------------------------
-------------------------
>Oryzias_latipes_NIPAL2_a
--------------------------------------------------------------------------------
------------------------MENASVSAQGQAHQAQ--------IMENPLQNYLLGILISICGNVLISFSLNIQKY
AHVRQ--------AQRG-SKPYYTSGVWWC--GVTL---MGVGELGNFAAYGFAPASLIAPLGCVSVIA---SVVISVVF
LKETVYTSDIV--------GGTLAITGTYLLVTFAPHTSTHITAHLVQYYFISWH--FLLYLLIE--------IILFCIL
LYLYKRR-NVKHIVVVMLLVALLAS--LTVISVKAVSGMITESIQG----QLQLIYPIF-YVMLVVMVASCGFQIKFLNQ
AMKMFDA-TEVVPINFVFFTTSAIVA-----GIVFYQEFEGLALLNILMFLLGCLLSFLGIFLIARNRPKIKQQDSNFIE
MNRIP-------GRTRTDKVQPEAKTPTYGSLAAKLMCSSTGQTDES---------------------------------
-------------------------
>Ciona_intestinalis_NIPAL2
--------------------------------------------------------------------------------
---------------MAHHV--------------------------------------IGMTLAISGNLLISVSLSVQKK
AHNRLGHHSQAK---------YCMDKWWWT--GMLL---MVLGELGNFMAYGFAPASLVAPLGSVAVLA---NAVIAVVF
LREPLTTSSMMG--------VTLVLMGSLTLISFSAKTRPTLSSEQIMEYLKAWT--FLLYIGIE--------AIVLIVL
LF-IKYVRKNEHLVILLLLVGIIAS--VTVIASKAISTMISESIFQN---KLQIMNVVF-WVCLVILPITTATQIRLLNR
AMQLYDV-SDVVPVNFMFFTVSAVLA-----GAIFYKEFEGVAFDRVFMFIFGCLLSFAGVYIIS---------------
--------------------------------------------------------------------------------
-------------------------
>Ciona_savignyi_NIPAL2
--------------------------------------------------------------------------------
-----------MIGINVTSTPGAHYSSATNATSHFS-FNPYS----------------LGTALAVIGNTLIAVSLNVQKY
AHRKRETQEEEEESSLCGPNSYLRSYTWWV--GIVL---MAVGEVGNFVAYGFAPASVVAPLGCVAVLV---NGGLAMVF
NNESLRMRDVVG--------ASFAIVGSFLVVTFSSKPKLILNAQELIAHLGGWQ--FIIYMFLE--------IVMFGII
IF-IKS-QDVKNVFIHLSLVAILGS--FTVISAKAVSGLLALTLEG----KSQLGEPIL-YIMVVIMIGTTLFQVKYLNA
AMRLYDI-ATVVPINFVLFTISAILA-----GTLFYQELSREPGINILMFIFGCLLSFMGVIFIAGDKGERGDPHEAGAL
HLDMMPNFVRYLAPSFLTTEVQPVRNDHQSKCYPDHEPGCSSGSDGSEGTEGTYDADYTQHNSTLDTET-----------
-------------------------
>Nematostella_vectensis_NIPAL2
--------------------------------------------------------------------------------
-----------------------------------------F----------------VGSALAICGNLLISVSMNIQKY
SHIQQ--------EKSNNETHYLKSKVWWC--GLIL---MVLGEVGNFSAYGFAPASLVAPLGTTTVIA---NAVIAVVF
LKEKIRYQDVFG--------VLLAIVGAFLLITFSTKDYAELTGQELAFYMKQWP--FLFYLVIE--------IVTFCVL
LY-VQMRYNLENVVVFLLLVALLGS--LTVISAKAVSSMINITLGG----DNQLGYPLL-YIMLIVMVTTAIAQVKFLNR
AMKSFDA-TVVVPTNFVLFTISAIIS-----GIVLYREFYGLTFLEIFMFLFGCVLSFIGVYYITSDRK-----------
--------------------------------------------------------------------------------
-------------------------
>Hydra_magnipapillata_NIPAL2
--------------------------------------------------------------------------------
--------------MNGTTTN---PLSTSAVPPTFPRNERIL----------------LGVVLAITGNLLISVSMNIQKY
SHN-----------KLIPGTSYIKSLTWWG--GIIL---MAIGEVGNFSAYAFAPASLVAPLGTTTVIA---NAVIAVVF
LKEKIRYRDVLG--------IVLAIVGAFLLITFSNKNDTMLSAQEILVYIKQWS--FLVYMGLE--------IVAFIVF
LF-WDKYYEVGKIIVILLQVAILGS--FTVITAKAVSSMLTITFRG----YSQLNQPIF-YIMFAIMVATAVAQVRFLSK
AMSLFDT-TMVVPTNFVFFTMSAIIG-----GIVFYREFYGLLFLDIFMFLFGAFLSFGGVYLITAERKKVDVPSSEDEN
VVLIP-------------CTPTITTNDLVATSLQLHEVYDNPALLGFDGIEEKSDFVTS---------------------
-------------------------
>Homo_sapiens_NIPAL3
--------------------------------------------------------------------------------
---------------MDGSHSAALKLQQLPPTSSSSAVS---------EASFSYKENLIGALLAIFGHLVVSIALNLQKY
CHIRL--------AGSKDPRAYFKTKTWWL--GLFL---MLLGELGVFASYAFAPLSLIVPLSAVSVIA---SAIIGIIF
IKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWP--FLLYMLVE--------IILFCLL
LYFYKEK-NANNIVVILLLVALLGS--MTVVTVKAVAGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAVYQAAFLSQ
ASQMYDS-SLIASVGYILSTTIAITA-----GAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNR-KKPIPFEPYIS
MDAMP--GMQNMHDKGMTVQPELKASFSYGALENNDNISEIYAPATLPVMQEEHGSRSASGVPYRVLEHTKKE-------
-------------------------
>Pan_troglodytes_NIPAL3
--------------------------------------------------------------------------------
---------------MDGSHSAALQLQQLPPTSSSSAVS---------EASFSYKENLIGALLAIFGHLVVSIALNLQKY
CHIRL--------AGSKDSRAYFKTKTWWL--GLFL---MLLGELGVFTSYAFAPLSLIVPLSAVSVIA---SAIIGIIF
IKEKWKPKDFLRRYVLSFVGCGLAVVGTYLLVTFAPNSHEKMTGENVTRHLVSWP--FLLYMLVE--------IILFCLL
LYFYKEK-NANNIVVILLLVALLGS--MTVVTVKAVAGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAVYQAAFLSQ
ASQMYDS-SLIASVGYILSTTIAITA-----GAIFYLDFIGEDVLHICMFALGCLIAFLGVFLITRNR-KKPIPFEPYIS
MDAMP--GMQNMHDKGMTVQPELKASFSYGALENNDNISEIYAPATLPVMQEEHGSRSASGVPYRVLEHTKKE-------
-------------------------
>Mus_musculus_NIPAL3
--------------------------------------------------------------------------------
---------------MDGAHSAGLQLQPLPPTSGATSTSLSS-----SEGSFSYKENLIGALLAIFGHLVVSIALNLQKY
CHIRL--------AGSKDPRAYFKTKTWWL--GLLL---LLLGELGVFASYAFAPLSLIVPLSAVSVIA---SAIIGIIF
IKEKWKPKDFVRRYVLSFVGCGLAIVGTYLLVTFAPNSHEKMTGENIARHLVSWP--FLLYMLVA--------IVLFCLL
LYFYKER-NANSIVVILLLVALLGS--MTVVTVKAVSGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAIYQATFLSE
ASQIYDS-SLIASVGYILSTTAAITA-----GAIFYLDFLGEEALHICMFALGCLIAFLGVFLITRNR-KKAIPFEPYIS
MDAMP--GMQDMHAKGTTVQPDLKASFSYGALESNDSISELYTPATLPVMQEEHSSRSTPGVPYRVLEHTKKE-------
-------------------------
>Rattus_norvegicus_NIPAL3
--------------------------------------------------------------------------------
---------------MDGAHSAGLQLQPLSPTSGATSPSLSS-----GEGSFSYKENLIGALLAIFGHLVVSIALNLQKY
CHIRL--------AGSKDPRAYFKTKTWWL--GLLL---LLLGELGVFASYAFAPLSLIVPLSAVSVIA---SAIIGIIF
IKEKWKPKDFVRRYVLSFVGCGLAIVGTYLLVTFAPNSHEKMTGENIARHLVSWP--FLLYMLVA--------IVLFCLL
LYFYKEK-NANSIVVILLLVALLGS--MTVVTVKAVAGMLVLSIQG----NLQLDYPIF-YVMFVCMVATAIYQATFLSQ
ASQIYDS-SLIASVGYILSTTVAITA-----GSIFYLDFLGEEALHICMFALGCLIAFLGVFLITRNR-KKAIPFEPYIS
MDAMP--GMQDMHAKGMTVQPDLKASFSYGALENNDSISEIYTPATLPVMQEEHSSRSTPGVPYRVLEHTKKE-------
-------------------------
>Gallus_gallus_NIPAL3
--------------------------------------------------------------------------------
---------------MEGGNSPNMQLQQIPLATAAVSVQP-------HTDSFSYKENLIGALLAIFGHLVISIALNLQKY
SHIRL--------AGSKDSRAYFKTKTWWC--GLFL---LVLGELGVFSSYAFAPLSLIVPLSAVSVIA---SAIIGIIF
IKEKWKPKEFLRRYVLSFVGCGLAIVGTYLLITFGPNSHEKMTGENITRHLVSWP--FLLYMLVE--------IIIFCLL
LYFYKEK-NANYIVIILLLVALLGS--MTVVTVKAVAGMIVVSIRG----NLQLNYPIF-YIMLVCMIATAVFQATFLAQ
ASQLYDS-SQIASIGYILSTTVAITA-----GATFYLDFTGEDVLHICMFALGCLIAFLGVFLITRNR-KKSVPFEPYIS
MDAMP--GMQNMHDKGIAVQPDLKASFSYGALENNDNMPEIYTPATLPIVQEQHGSRGVSAPPYRVLEHSKKE-------
-------------------------
>Danio_rerio_NIPAL3_a
--------------------------------------------------------------------------------
-----------------------MNSVSMAQKDGMLADS--------------YTDNLIGTLLAIFGNLLVSISVSIQKQ
SHVTL--------AGNKDPRQYYYTKTWLL--GLVL---MVLGEGALFVSYAFAPLSLIAPLNAVSVIS---SSILGFLF
LREKWKAQEFLKRYILTFLGCAMTAGGTYLFVTFGPNSHEKLNAENIVKHVISWP--FLLYLLLG--------IIAFCLV
LYYYKQR-NANYLVLILLLVALLGS--VTVITVKAVSGMIVLSIVG----PLQLSYPIF-YVMFVCMVATIVFQASFLAQ
ASHLYDS-SLIACVNYIFCTTFAIGG-----GAVFYQEFNHEDVLHICLFLLGCAICFLGVFLITKNK-RKAKSFEPYVT
MDMA--KGIPTIHNKGWAVQPDYNGSFSYGALENNDSV----APVTLPVNHEQSVSPGPVSSYQPSELKKD---------
-------------------------
>Danio_rerio_NIPAL2_a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------MFE--------ALLFAIL
MYLYKCR-NVKHIIIMMILVALLAS--VTVISVKAVSGMITETLRGS---HLQLTYPIF-YIMFIIMITSCAFQIKFLNE
AMKLFDA-TEIVPINYVFFTASAVVA-----GILFYEEFYGISLVHVLMFGVGCLLAFTGVFLIARARPRIK-MDSVFIS
MEQMP-------G-----KCVCVCVCVCIVSVC-----------------------------------------------
-------------------------
>Takifugu_rubripes_NIPAL3_a
--------------------------------------------------------------------------------
----------------------------MDSS-HSDAGS--------------YTDNLIGTLLAIFGNVLVSISLCIQKY
SHLKL--------AGAKDPRTFYRTKTWWC--GFIL---TCLGEGANFVSYAFAPLSLIAPLNAVSIVA---SSILGLLF
LLEKSKTKDFLKRYGLSFFGCVLTIGAIYLFVTFGPNSHEQLKAENIVKHVVAWP--VLLYLLVE--------IITFCLL
LYFYKQH-RANYLIVIVLLVSLLSS--VTVITVKALSSMLVLTVRG----TMQLNYPIF-SVMLVCMVASIVFQARFLSQ
ACKLFEP-SLIASVNYILSTFFAIVA-----GAVFYLEFKSEDVLHICLFLLGSALCFLGVFLITKNR-KNPQTFEPFVT
MDMASAKGVPTIHDKG---LVDFNGSFSYGTLVNADGV----ARTTLPVKLDQPPIRSRS--------------------
-------------------------
>Tetraodon_nigroviridis_NIPAL3_a
--------------------------------------------------------------------------------
----------YNNSHRLRIKRQRLKTITMDSS-QTDIDS--------------YTENLIGTLLAIFGNALVSISLCIQKY
SHMRL--------AGAKDPRPFYCTKTWWC--GFVL---TVLGEGANFVSYAFAPLSLIAPLNAVSIVA---SSILGLIF
LLEKSRPKSFAKNYGLSFFGCVLTIGAIYLFVTFGPNSHEQLKAENIVKHVVAWP--VLLYLLVE--------IVAFCLL
FYFYKTH-HANYLIISLLLVSLLGS--VTGITVKAVSSMLVLTVKG----TMQLNYPIF-SVMFVCMVASVAFQARFLSQ
ACKLYEP-SLIASVNYILTTSLAIVA-----GAVFYLEFKNEDVLHICLFLLGSAFCFLGVFLITKNR-KNPQTFEPFVT
MDM---KGVPTIHDKG---LVDFNGSFTYGTLVNEDGV----AQ------------------------------------
-------------------------
>Gasterosteus_aculeatus_NIPAL3_a
--------------------------------------------------------------------------------
---------------------------MMFLY-GAYGGS--------------YTDNLIGTLLSIFGNVLVSISLSIQKY
SHVKS--------AGAKDVRVFYHTKTWWS--GFVL---ICLGEGANFVSYAFAPLALITTLNAVSVLT---SSILGLIF
LREKLRPKAFAKRYGLSFLGSILISGGTFLFVVFGPNSHEKLKAENIVTHLVGWP--VLLYMLLE--------IVTFCLL
LYFYKQR-NANYLVVILMLVALLNS--VTVITVKAVSGMLVLSIEG----SMQLDYPIF-SVMFVCMVASVVFQARFLSQ
ACNLYDS-SLIAGVNYILSTVSAVVA-----GAVFYVEFKNEDVLHVCMFLLGSAFCFLGVFLISKNR-KRTKTFEPYVT
MDMVNASGVPTIHDRGLFVQPDSNGTFSYGALVNNDGA----APVTLPVDPEQPPVASMRIDPPSGRRD-----------
-------------------------
>Oryzias_latipes_NIPAL3_a
--------------------------------------------------------------------------------
-------------------------GEKMGFY-SSHGES--------------YTDNLIGTLLAIFGNFLVSISLSIQKY
SHVTL--------AGRKDQRTFYHTKTWWC--GFVF---TCIGESANFVSYAFAPLAVVAPLNAVSVLT---SSILGFLF
LHEKSKPKEFAKHYGLIILGYFITAGGTYLFVSFGPNSHEKLEAENIIKHIVGWP--VLLYLLLE--------IILFCLL
LYFHKQR-RVNYLVVILLLVALLGS--VTVITVKAVSGMLVLSIEG----NIQLDNPIF-SVMFVCMMASVIFQARFLSQ
ACKLHDS-SLVMSVNYILSTVFAVVA-----GAVFYLEFNKEEVLNICMYVLGSVLCFLGVFLMTKNR-KKPKIFEPYVS
MDMSN--GVPTIHDKGSVVQPDFNGSFSYGTLVNNDGV----APAPLPVNLEQPVVSSRTSDAPTGQLDRKND-------
-------------------------
>Homo_sapiens_NIPAL4
MPGDSSPGTLPLWDASLSPPLGPDPGGFSRASHAGDKSRPPAPELGSPGAVRPRVGSCAPGPMELRVSN--TSCENGSLL
HLYCS--SQEVLCQIVNDLSPEVPSNATFH---------------SWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKK
GLLRLVATGATRAV--DGGFGYLKDAMWWA--GFLT---MAAGEVANFGAYAFAPATVVTPLGALSVLIS---AILSSYF
LRESLNLLG--------KLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDT--GFIVFAVLL--------LVSCLIL
IFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLP-----VVRHPLPYILSLILAL--SLSTQVNFLNR
ALDIFNT-SLVFPIYYVFFTTVVVTSS-----IILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASL-PH
MHKNP-PP------SPAPEPTV----IRLEDKNV-------------LVDNIELASTSSPEE-KPKVFIIHS--------
-------------------------
>Pan_troglodytes_NIPAL4
----------PLWDASLSPPLGPDPGGFSRASHAGNKSRPPAPELGSPGAVRPRVGSCAPGPMELRVSN--TSCENGSLL
HLYCS--SQEVLCQIVNDLSPEVPSNATFH---------------SWQERIRQNYGFYIGLGLAFLSSFLIGSSVILKKK
GLLRLVATGATRAV--DGGFGYLKDAMWWA--GFLT---MAAGEVANFGAYAFAPATVVTPLGALSVLIS---AILSSYF
LGESLNLLG--------KLGCVICVAGSTVMVIHAPEEEKVTTIMEMASKMKDT--GFIVFAVLL--------LVSCLIL
IFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLP-----VVRHPLPYILSLILAL--SLSTQVNFLNR
ALDIFNT-SLVFPIYYVFFTTVVVTSS-----IILFKEWYSMSAVDIAGTLSGFVTIILGVFMLHAFKDLDISCASL-PH
MHKNP-PP------SPAPEPTV----IRLEDKNV-------------LVDNIELASTSSPEE-KPKVFIIHS--------
-------------------------
>Mus_musculus_NIPAL4
--------------------------------------------------------------MELRVANANGSCENGSIV
SLYCS--SQEVLCQIVRGISPEEPYNATLI---------------TWQERVRKKYGFYIGVGLAFLSCFLIGTSVILKKK
GLIRLVATGATRAV--NGGYGYLKDPMWWA--GMAT---MSAGEVANFGAYAFAPATVVTPLGALSVLIS---AIFSSYC
LGESLNLLG--------KLGCVICMAGSTVMVIHAPKEEKVTTVAEMASKMKDT--GFIVFAVLL--------VVSCLIL
IFIVAPRYGQRNILIYIIICSVIGSFSVTAVKGLGVTIRNFFQGLP-----VVRHPLPYILSLILGL--SIIIQVNFLNR
ALDIFNT-SLVFPIYYVFFTTVVVASS-----IVLFKEWYTMSAVDIVGTLSGFVTIILGVFMLHAFKDLDINQISL-PH
THKNP-TP------APAPEPTV----IKLEDKNV-------------LVDNIELASTPSPQQ-KPKVFMTDS--------
-------------------------
>Monodelphis_domestica_NIPAL4
------------------------------------------METLGSNSSC----------------------ANGSLI
TLYCY--SQQVLCQIVSDFEPDSSNNITLS---------------SWQKRATKNYGFFIGVGLAILSSFLIGSSVILKKK
GLVRLVDKGATRAV--DGGFGYLLDKMWWA--GFLT---MALGEAANFGAYIFAPATVVTPLGALSVLIS---AILSSYF
LGERLNLLG--------KLGCMIAIAGSSVMVIHAPEEEKVNSINEMASKLKDT--GFIVFAVLL--------LVSSLIL
IFIIAPRYGQKNILVYIIICSVMGSYSVCAVKGMGIAIKGFFKGQP-----VLRHPLTYCLGLILAT--SIPIQVNFLNR
ALDIYNT-SLVFPIYYVTFTSTVITSS-----IILFKEWNSMSVVDILGTISGFITIILGVFLLYAFKDLDITWESL-PH
THKNP-IP------PPTPEPTI----IKLEDKNV-------------LVDNIELP-PPSPEE-KPKVFTIHT--------
-------------------------
>Ornithorhynchus_anatinus_NIPAL4
---------------------------------MPAPKPTLPGKSFQVSSHCPARGTVICGPLRSALCFGAIPSINSSLL
TLHCS--SQQVLCQIIGELGLEASDNATSS---------------SWQEKAKRNYGFFIGLGLAVFSSFLIGSSVILKKK
GLLRLVAKGATRAV--DGGYGYLKDSMWWA--GLLT---MAAGEAANFGAYAFAPATVVTPLGALSVLIS---AILSSYF
LGEGLNLLG--------KLGCAICVAGSTVMVIHAPEEEMVTTLDEMVSKLKDT--GYIVFAVLN--------LVTCLIL
IFFIAPRYGQKNILIYIIICSGIGAFSVSAVKGLGIAIKGFFQHQP-----VLQHPLSYILVLILAA--SLSTQVNFLNR
ALDVFNT-SLVFPIYYVFFTTMVITSS-----IILFKEWTTMTAMNVVGTISGFVTIILGVFLLHAFKDLSISWSNL-PH
THTDP-TP------PPDPEPIV----IKLEDKGI-------------LVDNMEMP-IPLPEE-KPKVYIVNG--------
-------------------------
>Gallus_gallus_NIPAL4
------------------------------------------------------------MMMEPLAAN--SSCSNGSLL
SISCL--SHQVVCQVVGGADLADPVHDNGTG------------DTSWVTQLESNYGFYIGLGLAVFSSFLIGSSIILKKK
GLLRLVEKGGTRAG--DGGHGYLKDWLWWA--GLLT---MGGGEAANFAAYAFAPATIVTPLGALSVLI--S-AILSSYL
LGERLNLLG--------KLGCMLSLVGSTVMVIHAPEEEEVTTLDEMLFKLKEP--GFLAYAVVL--------LAICFLL
ILYLAPRYGRSNILIYLTICSVIGAFSVSSVKGLGIAIKGFFAGQP-----VLQHPLTWILVITLVA--SITTQINYLNK
ALDIFNT-SLVFPIYYVLFTTIVITTS-----IILFKEWVAMTVVDIIGTVCGFLTIILGVFLLHAFKDMDVNLGNL-PQ
VLQSE-----------QEAPVI----R--DDKNI-------------LIE-VDNSSIAPED--KSKALA-----------
-------------------------
>Danio_rerio_NIPAL4_a
---------------------------------------------------------MGVTMKDIHLPS--DSCINGSVI
RIFCP--TSASICVFDTAVGNTSYSLDNSNKNLT-------VSTQSLAIDKWSNYNFWTGLTLAVLSAFLIGGSVILKKK
ALLRLANTGETRAA--EGGHGYLKDWLWWG--GLLT---MGGGEAANFAAYMFAPATVVTPLGALSVLIS---AVLSSHL
FRETMNLLG--------KLGCMLSVLGSTLMVIHAPEEEEVTTLKEMAEKLLDP--GFLVFASIL--------LVTCLIL
IFYVSPRFGQSNILVYISICSLLGSFTVSSVKGLGIAIRTMFTDTS-----VVRNPLMWILLLTLIG--SIIIQVNYLNK
SLDTFNT-LLVYPIYYVFFTTVVLSTS-----VILFKEWGAMSGVDVVGTIGAFLVIVIGVSMLNIFKDLNVCFEDLRSN
LCQ--PLS------QESPSKR--------EDKHI-------------LIEN--IETLPPMREEGPRVFIIS---------
-------------------------
>Takifugu_rubripes_NIPAL4_a
----------------------------------------------------------------VQLHN--ETCVNGSVV
RLWCG--SQSTVCVITGET--VVYSSLNNN-------------TQTTELQTTRSYKLWLGLTLALLSAFLIGGSVILKKK
ALLRLATSGHTRAG--DGGHGYLKDWLWWG--GLLT---MGAGEACNFAAYMFAPATLVTPLGALSVLIS---AVLSSYL
LGETLNIMG--------KLGCLLCLLGSILLVIHAPQEQEVTSLQDMTNKLLEP--GFLVYMSVV--------LVLCGVL
VLYLCPRLGQSNILIYISICSLLGAFTVSSVKGLAIAIDTVLYDVS-----VLANPLTWILLLTLIV--SVVTQVNYLNK
SLDTFNT-LLVYPIYYVLFTSVVLSTS-----IILFQEWRSMAAVDVVTTLGAFVVIVVGVAMLHLFREMQLSAPGAGPQ
LNQEAPPT------QQAEGRRR----KKKEDKHG-------------LMDNMVIESLPPMREEGPRVFIIST--------
-------------------------
>Homo_sapiens_NIPA1
--------------------------------------------------------------------------------
-----------------------------MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKK
GIVRAKR----------RGTSYLTDIVWWA--GTIA---MAVGQIGNFLAYTAVPTVLVTPLGALGVPFG---SILASYL
LKEKLNILG--------KLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNP--VFVGYLCIV--------LLMLLLL
IFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPS----SQ-RALCLCLVLLAVLGCSIIVQFRYINK
ALECFDS-SVFGAIYYVVFTTLVLLAS-----AILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKS
NMKTD---------------------------------------------------------------------------
-------------------------
>Mus_musculus_NIPA1
--------------------------------------------------------------------------------
----------------------------------MGTAAAAAAAG-EGARGPSPAAVSLGLGVAVVSSLVNGSTFVLQKK
GIVRAKR----------RGTSYLTDIVWWA--GTIA---MAVGQIGNFLAYTAVPTVLVTPLGALGVPFG---SILASYL
LKEKLNILG--------KLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNP--VFVGYLCIV--------LLMLLLL
IFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPS----SQ-RALCLCLVLLAVLGCSIIVQFRYINK
ALECFDS-SVFGAIYYVVFTTLVLLAS-----AILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKS
NMKTD---------------------------------------------------------------------------
-------------------------
>Rattus_norvegicus_NIPA1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------GTSYLTDIVWWA--GTIA---MAVGQIGNFLAYTAVPTVLVTPLGALGVPFG---SILASYL
LKEKLNILG--------KLGCLLSCAGSVVLIIHSPKSESVTSQAELEEKLTNP--VFVGYLCIV--------LLMLLLL
IFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPS----SQ-RALCLCLVLLAVLGCSIIVQFRYINK
ALECFDS-SVFGAIYYVVFTTLVLLAS-----AILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKS
NMKTD---------------------------------------------------------------------------
-------------------------
>Danio_rerio_NIPA1_a
--------------------------------------------------------------------------------
--------------------------------------------------MDETPFPVVGVVIAVVSSFINGSTFVLQKK
GILRARK----------SGGTYLADCVWWC--GTLA---MIVGQIGNFLAYNVAPAVVVTPLGALGVLFG---AVLASWL
LQEHLDLIG--------KLGCILCCCGAVVLIIHSPKSENVTSRAELEERLMDP--VFQVYISLV--------VILLIIL
IGWLSPAHGKSNIMVYVGICSLLGSFTVPSSKGLGLAAQEAFSQTPS----SDGRAFFLFLGLLGVLVVSILIQFTFINK
ALENFSS-NMFEAIYYVTFTSCVILAS-----AVLFREWTALGIVDCLGILCGFVTVSVGVALLRISQEAKLTWSQTKDK
EN------------------------------------------------------------------------------
-------------------------
>Takifugu_rubripes_NIPA1_a
--------------------------------------------------------------------------------
-----------------------------------------------------------GILIAVVASFINGSTFVLQRK
GILRSRE----------KGRSYLTDVFWWT--GTLS---MAVGQIGNFLAYNVAPAVIVTPLGALGVLFG---ALLASWI
LKEHLNLLG--------KLGCVLCCSGSVMLVVHAPRAEAVTSRTEFEERLLDP--VFVAYALLV--------LLLLLVL
IVWVAPAHGSSNIMVYICICSLLGSFTVPSSKGLGLVAKDVLAEGPP----SS-RALALFLALLAVLATSILTQFLFINK
ALERFSS-NTFEAIYYVTFTSSVILAS-----ALLFKEWTALNVAGCLSMVCGLATTCVGVVLLRISQE-----------
--------------------------------------------------------------------------------
-------------------------
>Tetraodon_nigroviridis_NIPA1_a
--------------------------------------------------------------------------------
-----------------------------------------------------------GILIAVAASFINGSTFVLQRK
GILRSRE----------RGRSYLTDVVWWT--GTLSTITVAIGQIGNFLAYNFAPAVVVTPLGALGVLFG---ALLASWI
LKERLNFLG--------KLGCVLCCSGSVVLILHAPKAEAVTSRTEFEERLLDP--VFVSYVLLV--------LLLLLVL
IVRIAPAHGSSNIMVYVCICSLLGSFTVPSSKGLGLVAPDVLG-GPP----SG-RALALFLALLAVLAASVLTQFLFLTK
ALQRFGS-STFEAIYYVTFTSSVLLAS-----ALLFREWTSLELPDGLALLCGLATSSVGVLLLRLSQE-----------
--------------------------------------------------------------------------------
-------------------------
>Gasterosteus_aculeatus_NIPA1_a
--------------------------------------------------------------------------------
--------------------------------------------------QTSVSFPVSGVVIAVVSSCINGSTFVLQKK
GILRSRD----------RGCSYLTDVVWWS--GTLA---MIIGQIGNFLAYNVAPAVIVTPLGALGVLFG---AVLASRV
LGEQLNILG--------KLGCVLCCCGSVVLVMHAPKAAAVTSRLELEAGLSDP--VFVAYGLLL--------VLLLLVL
IAWIAPAHGSSNVMVYVAICSLLGSFTVPSSKGLGLVAPGVLG-AEP----G---ALPLFLGLLATLAVSVLLQFFFINK
ALERFSS-NVFEAIYYVAFTSSATVAS-----GLLFKEWTALTAAGAAAMLCGLTTVCVGVVLLRISQEASVTWRTTKKT
E-------------------------------------------------------------------------------
-------------------------
>Oryzias_latipes_NIPA1_a
--------------------------------------------------------------------------------
--------------------------------------------MADGSELPVASSETAGIVIAVLSSFVNGCTFVLQKK
GILRSRE----------KGVSYVTDLVWWS--GTLC---MIIGQIGNFLAYNVAPVVIVTPLGALGVLFG---AVLASWI
LEEHLNILG--------KLGCLLCCCGSIVLIIHSPKAEAT-SRAEFEERLFDP--VFVTYILLV--------VVLLIVL
IVWIVPAHGTSNILVYVSICSLLGNFTVPCSKGLGLVAPDAFGGGAA----SG-EALALLLGLLGTLAVSILTQFYFINK
ALECFSS-NIFDAIYYVAFTSSVIFAS-----AILFKEWTALAVTDCLAMLCSLTVVCVGVVLLRISQAALISWRKEPTK
DKMN----------------------------------------------------------------------------
-------------------------
>Homo_sapiens_NIPA2
--------------------------------------------------------------------------------
-----------------------------------------------MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKK
GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEVANFAAYAFAPATLVTPLGALSVLVS---AILSSYF
LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATLV--------VIVALIL
IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKP-----VLRHPLAWILLLSLIV--CVSTQINYLNR
ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVS
FRKDEK-------AMNGNLSN---MYEVLNNNEE------------SLTCGIEQHTGEN-VSRRNGNLTAF---------
-------------------------
>Pan_troglodytes_NIPA2
--------------------------------------------------------------------------------
-----------------------------------------------MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKK
GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---M---------------------------LVS---AILSSYF
LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATLV--------VIVALIL
IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELFAGKP-----VLRHPLAWILLLSLIV--CVSTQINYLNR
ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVS
FRKDEK-------AMNGNLSN---MYEVLNN-DE------------SLTCGIEQHTGEN-VSRRNGNLTAF---------
-------------------------
>Mus_musculus_NIPA2
--------------------------------------------------------------------------------
-----------------------------------------------MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKK
GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEVANFAAYAFAPATLVTPLGALSVLVS---AILSSYF
LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATFV--------VIVALIF
IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGIAIKELLAGKP-----VLQHPLAWILLFSLVV--CVSTQINYLNR
ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVS
FRKDEK-------AMNGNLSS---MYEVLNNNED------------DLPCGIE-HTGEN-ISRRNGNLPSF---------
-------------------------
>Rattus_norvegicus_NIPA2
--------------------------------------------------------------------------------
-----------------------------------------------MSLGRGKYDFYIGLGLAMTSSIFIGGSFILKKK
GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEVANFAAYAFAPATLVTPLGALSVLVS---AILSSYF
LNERLNLHG--------KIGCLLSILGSTVMVIHAPKEEEIETLNEMSHKLGDP--GFVVFATFV--------VIVALIF
IFVVGPRHGQTNILVYITICSVIGAFSVSCVKGLGITIKELLAGKP-----VLQHPLAWILLLSLVV--CVSTQINYLNR
ALDIFNT-SIVTPIYYVFFTTSVLTCS-----AILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFKDVSFSLASLPVT
FRKDEK-------AVNGNLSN---MYEVLNNNEE------------DLPCGIE-HTGEN-ISRRNGNLTSF---------
-------------------------
>Danio_rerio_NIPA2_a
--------------------------------------------------------------------------------
-----------------------------------------------MGQDRGKYDFYIGLALAISSSIFIGGSFILKKK
GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLV--S-AVLSSYF
LTERLNLHG--------KLGCLLSILGSTTMVIHAPQEEEIDSLKDMAKKLVDP--GFVVFATAV--------IIIALIF
IFVLGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGKP-----VLRNPLAWLLLLSLIA--CVSTQINYLNK
ALDIFNT-SLVTPIYYVFFTTSVLSCS-----AILFKEWEHMGVDDIIGTLSGFVTIIVGIFLLHAFKDVSISLATLAVS
IRKDERNGPV----SNGMAAHNHSNYELLRNEVT------------EDFEDREPGLPFDSVSRRNGTMTVS---------
-------------------------
>Danio_rerio_NIPA2_b
--------------------------------------------------------------------------------
------------------------------------------------MDVANRSDFYIGLALAVSSTIFIGGSFILKKK
GLLRLASKGSTRA--GQGGYAYLKEWLWWA--GLIS---MGIGEAANFAAYAFAPATLVTPLGALSVLVS---AVLSSYF
LSERLNIHG--------KIGCLLCIFGSTVMVLHAPQEEEVASLSAMAEKLKDP--GFIAFAVCI--------VVSSLVL
IIFVAPRYGQKNVLVYILICSVIGSLSVSCVKGLGIGIKELFGGTA-----VLKDPLFWALLICLVV--CISIQISYLNK
ALDIFNT-SIVTPIYYVFFTTSVMACS-----AILFKEWLRMSTDGAAGTVSGFLTIIIGIFLLHAFKDINFSLDSLPLY
LHHGLRG--------HAYVALP--TDERIDESSL-------------TKERSATFFPDSSDKRSNGTFIA----------
-------------------------
>Takifugu_rubripes_NIPA2_a
--------------------------------------------------------------------------------
-----------------------------------------------MGQDRGKYDFYVGLALAVSSSIFIGGSFILKKK
GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLV--S-AVLSSYF
LTERLNLHG--------KLGCLLSILGSTTMVIHAPQEEEITSLEDMAEKLVDP--GFCVFATLV--------IIVALIF
IFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGKN-----VVGNPLAWILLLGLVA--CVSTQINYLNK
ALDIFNT-SLVTPIYYVFFTTSVLTCS-----AILFKEWGHMGSDDVIGTLSGFSTIIIGIFLLHAFKDISVSLANLAVS
MRKEERAFPT----ANGLGSHST--YEMLH-ESN------------EDMEDRDMGSSFDSVSRRNGAMTSL---------
-------------------------
>Tetraodon_nigroviridis_NIPA2_a
--------------------------------------------------------------------------------
-----------------------------------------------MGQDRGKYDFYVGLALAVSSSIFIGGSFILKKK
GLLRLARKGSMRA--GQGGHAYLKEWLWWA--GLLS---MGAGEGANFAAYAFAPATLVTPLGALSVLV--S-AVLSSYF
LTERLNLHG--------KLGCLLSVLGSTTMVIHAPQEEEITSLEDMAHKLVDP--GFCVFATLV--------IIVALIF
IFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGKK-----VASHPLAWVLVLGLVA--CVSTQINYLNK
ALDIFNT-SLVTPIYYVFFTTSVLLCS-----AILFKEWGHMGPDDVIGTLSGFLTIIIGIFLLHAFKDVSVSLANLAVS
MRKEERAFPA---NANGLAAHAT--YKVLRNESG------------EEAEERE---------------------------
-------------------------
>Tetraodon_nigroviridis_NIPA2_b
--------------------------------------------------------------------------------
------------------------------------------------MEV-NRLDFYIGLALAVSSSVFIGASFILKKK
GLLRLARKGSTRA--GQGGHAYLKEWLWWA--GLIS---MGIGEAANFAAYIFAPATLVTPLGALSVLVS---AVFSSYF
LNERLNIHG--------KVGCLLSILGSTVMVIHAPQEEEVGSLDAMADKLKDP--GFIVFAACV--------VGSSLLL
IFAVAPRFGQKNVLVYILICSVVGSLSVSCAKGLGIGIKELFAGEA-----VLKHPLFWSLLICLVI--CLSVQINYLNK
ALDIFNT-SIVTPIYYVFFTTSVMTCS-----AILFKEWLNMSVDGIVGTLSGFFTIVLGIFLLHAFKDIPFTWDSLPVF
IRKGPQGFPW---GHQSYTALP--NPNPLVENEV-------------KLPRDGSTTGGLSPDHRSQ--------------
-------------------------
>Gasterosteus_aculeatus_NIPA2_a
--------------------------------------------------------------------------------
-----------------------------------------------MGQDRGKYDFYLGLGLAVSSSIFIGGSFILKKK
GLLRLARKGSTRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLV--S-AVLSSHF
LTERLNLHG--------KLGCVLSILGSTTMVIHAPKEEEISSLEHMAEKLVDP--GFFIFATLV--------IIVALIF
IFVVAPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAVAGHS-----VASNPLSWILLLGLVA--CVSTQINYLNK
ALDIFNT-SLVTPIYYVFFTTSVLSCS-----AILFKEWGHMGAADVIGTLSGFLTIIVGIFLLHAFKDVSVSLASLAVS
MRKEERPSPA---AANGTASH----YELLL--RG------------ESPEDMEMGPPFESVSRRNGAMTL----------
-------------------------
>Oryzias_latipes_NIPA2_a
--------------------------------------------------------------------------------
-----------------------------------------------MGQDRGKYDFYIGLGLAISSSIFIGGSFILKKK
GLLRLAKKGSTRA--GQGGHAYLKEWLWWA--GLLS---MGAGEAANFAAYAFAPATLVTPLGALSVLVRCS-AVLSSYF
LTERLNLHG--------KLGCMLSILGSTTMVIHAPKEEEISSLEHMSKKLVDPATGFVVFATLV--------VIVALIF
IFVVGPRHGQTNILVYITICSVIGALSVSCVKGLGIAIKEAIAGTN-----VVKNPLAWVLLFSLVG--CVSTQINYLNK
ALDIFNT-SLVTPIYYVFFTTSVLTCS-----AILFKEWEHMGADDVIGTLSGFITIIVGIFLLHAFKDLNVSLAALAVS
MRKDDRPFPV-----NGVTSHST--YELVHEEST------------EDMEEREMGPPFDTISRRNGSMAS----------
-------------------------
>Oryzias_latipes_NIPA2_b
--------------------------------------------------------------------------------
------------------------------------------------MEG-NRVNFYIGLSLAVSSSAFIGASFILKKK
GLLRLASKGSMRA--GQGGHAYLKEWLWWA--GLIS---MGVGEAANFAAYAFAPATLVTPLGALSVLVS---AVLSTYF
LNEQLNIHG--------KVGCLLCILGSTVMVIHAPQEEEVGSLTAMAEKLKDP--GFIVFAVCV--------VGSSLVL
IFAVAPRFGQKNVLVYILICSVIGSLSVSCVKGLGIGIKELFSGTA-----VLKEPLFWSLVICLVI--CVSVQINYLNR
ALDIFNT-SIVTPIYYVFFTTSVMACS-----AILFKEWLRMTADGVVGTISGFLTIILGIFLLHAFKDIPFHWNSLPLY
LQKDPRDFSR---GQQPYETLS--SRDLETEGEA-------------GLSKSGRLNGGWRQHQSTA--------------
-------------------------
>Ciona_intestinalis_NIPA2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------MGEKLRDP--IFVTYAVAV--------LLVSLYL
IFYVAPRHGTSNVMVYISICSLLGSFSVSCVKGVGMVFKGFAAGDN-----VWIKPLTYVLIIGLVL--SVSTQVNYLNK
ALDVFNT-SMVTPVYYVLFTTTVLTCS-----AILFKEWNDMDARSVIGMLAGFGTIVTGIFFLHAFKDINFSLNDL-PK
FSKNGASD---QSVHYTTMMRN----H-TDERRE-------------LLDEVDLTMYSEDDEENSAVLFNKKPKDTLQNG
RIQR---------------------
>Ciona_savignyi_NIPA2
--------------------------------------------------------------------------------
--------------------------------------------------VAYGGGFYIGLGLAVSSSIFIGGSFILKKK
GLLRLAAKGTTRAG--DGGHAYLKEWMWWA--GLIT---MGAGEAANFLAYAFAPASLVTPLGALSVLVS---AVLSSYF
LDERLNLHG--------KMGCVLSILGSTVIVIHAPQTEEVADLADMGVKLRDP--IFVTYAVIV--------LAVSLYL
IFYIAPRHGTSNVMIYISICSLLGAFSVSCVKGVGLVVKGAAAGDP-----VWLQPLTYLLILGLIA--SVSTQVNYLNK
ALDVFNT-SMVTPVYYVLFTTTVLLCS-----AILFKEWNAMDPRSVIGMLAGFGTIVTGIFFLHAFKDINFSLSDL-PK
FVKNVGANGVVESVKYTSVRKA----HRSDERSE-------------LLDQVD-AIYSEEDE-SSNVL------------
-------------------------
>Strongylocentrotus_purpuratus_NIPA2
------------------------------------------------------------------MSPVAESDEPHKNI
TGAVWHELQQAISTQATSMTTITPSFMSTSNS---------TMACDISEETMTSEDFYIGLTLAICSSGFIGSSFVIKKQ
ALIKISAH-AVRAG--DGGHAYLREWLWWA--GFLL---LGLGELCNFMAYAFAPATLVTPLGALSVIVS---AVLSSYV
LNETLNLLG--------KLGCILCIMGSIIIVLHTPADEAFHTLGWLATRLRSP--SFVIYVCLV--------AASCLAL
VFAIGPRWGHTNILVYVLVCSLMGSLTVMASKGVGIAFVQLFDGTN-----TFVDPLTWILILLMVV--FITIQMHFLNK
SLDIFNT-AVITPIYYVFFTASVLIAS-----SLLFEDWRAMTATDIIAVLDGFGVIIVGIFLLHTFRDFSLSLTDLPSA
EKPSTSTG-----ATSVHRPRTDSEDCYINTESA------------CLLNDFNSKNDGILSEKDIA--------------
-------------------------
>Drosophila_melanogaster_NIPA2
--------------------------------------------------------------------------------
MNSDGEASSLQMPQVTVGGMLPVEANQSPETA------------PLSMAETVSNTDFYIGVGLAISSCFFIGSSFIIKKK
ALIRLSRYGEVRAS--AGGFGYLREWIWWA--GLLT---MGVGEAANFAAYAFAPASLVTPLGALSVIIS---AVMASRF
LNEKLNLLG--------KIGCFLCILGSTIIVIHSPKEKEIEDLQLLFDMLLDP--VFILYVICI--------VGSTVFV
ACFIAPRHGHTNVVVYIFLCSGIGSLTVMSCKALGLAIRQTLNNGGN----VFLTWMPWFLILVTVT--FIAIQMNYLNK
ALDIFNT-SIVTPVYYVMFTTLVIAAS-----AILFKEFTHMRFDDILGDVCGFLIVITAVFLLNAFRDIDISLNDVRGL
MRPKM-----------QRVSQF-------DEEVL-----------------VTSNTKERRLSYGSSDIFRKA--------
-------------------------
>Apis_mellifera_NIPA2
--------------------------------------------------------------------------------
--------------------------MSSITK------------IAFEVQLYNTTNFYIGLGLAISSSIFIGASFIIKKK
ALIRLQRRGALRAS--SGGFGYLKEWMWWT--GFLS---MGIGEAANFAAYAFAPASLVTPLGALSVLIS---AILASKY
LHEKLNLLG--------KIGCLLCILGSTILIIHSPKEEEINTLNELLDKVKDP--GYIVYILIV--------IICSILI
IFYFGPIYGKQNIIVYICLCSSIGSLTVTSCKGLGLALKETIFGFSN----GFSNWLTWAFLFSVIL--CVSIQMNYLNR
SLDLFET-TIVTPIYYVFFTTLVIIAS-----AILFKEWENMSAEDILGSFCGFLTIIIAIFLLNAFKEMDISYENIRRM
LQPKR-----------KLFINSNNQWNNRDEERL-----------------ITRLETELNHTYGAQALTRTI--------
-------------------------
>Anopheles_gambiae_NIPA2
--------------------------------------------------------------------------------
-------------KITRGVKKMPSAGAAAPPP------------PPAIDELYMERDFYIGLALALSSSIFIGSSFIIKKI
GLLRLSRVGSVRAS--AGGFGYLRDWIWWA--GLIC---MGVGEAANFAAYAFAPASLVTPLGALSVIVA---AVMASRF
LKERLNLLG--------KLGCFLCIVGSTIIVIHSPKEGEVEDLNLLIDMLQDP--TFITYVVLI--------LSLALFI
GCCIGPRYGHKHVAVYILLCSAIGSLTVMSCKALGLALRDTLSGKSN----DFGMWLPYFLIIVTVV--FVGIQVNYLNK
ALDIFNT-SIVTPIYYVIFTTLVITAS-----AILFKEWRHMRPEDIIGDLCGFFVVIVAVILLNAFREMDISLSDVKGI
MRPKR-----------ELLSH-----------------------------------------------------------
-------------------------
>Nematostella_vectensis_NIPA2
-------------------------------------------------------------------------------M
AVSTSAWPSTQGIATSDRMSRDASEAS--------------------------SRDFYTGLGLAISSSVFIGSSFIVKKK
GLLRVAQRSGVRAG--QGGYAYLKEWLWWI--GMIS---MIFGEIANFSAYAFAPAILVTPLGALSVLVS---AVLASYF
LDEKQNLHG--------KVGCILSIIGSTVLVIHAPQEEAVDTIEQLESKLIEP--GFIIYAVMV--------VLLAFVL
IWRYAPKYGKTNILVYIAICSLIGSLSVMGCKGVGIVLKQTLKGDS-----QVGNPVSWALLFTVLT--CATTQINYLNK
ALDIFNT-SLVTPIYYVMFTLLTIIAS-----AILFKEWKLMDTKDTIGSICGVLTIILGVFLLHAFKNVKFSLKDLNFF
QKQKGSRS----IQIGDGAEA-----MLMR------------------SVEEGSPDDED-EEIASSKLLTNNINHT----
-------------------------
>Hydra_magnipapillata_NIPA2
---------------------------------------------------------------------------MAVHL
HIAEIIDTATNTSLSTTTINMATSQIN--------------------------YGDYYKGLALALSSCVFIGTSFIVKKK
GLLRVSRTSGSRAG--EGGYAYLKEWMWWI--GLIT---MVVGEAANFTAYAFAPAILVTPLGAISVIVR---EIDEG--
LSKS-----------------AMKMVG----IKHG---IPKNTLQAFTGRL------FIGYTLLV--------LLISIFL
IIYVSPKYGKTNILVYIAICSLFGSLTVSACKGLGIAIKETLAHNS-----QVSNPIAWMLLIGGAL--CIMVQMNFLNK
ALDIFNT-SIVSPIYYVMFTTFAIIAS-----AILYKEWAKLNAKDALGSVCGFLTIIIGVFLLHAFKDIKFSFQDL---
-YGSVTIS----KNLTDGEAN-----VLIT------------------ELE---SDEEN-DSNISNNYLTSKF-------
-------------------------