>Homo_sapiens_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Pan_troglodytes_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQSFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Gorilla_gorilla_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Pongo_abelii_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIK-----------------------
------KTEFSF--------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Macaca_mulatta_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Callithrix_jacchus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSKRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVTSLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDAFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIVRT-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFSNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRIPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VFNWDSEKAT----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Mus_musculus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESESSRRMGN----ACIPLKRIAYFLCLFSVVLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CSKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNAFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEVLKIRKPNDIE
TFKIED------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIARP-------PLALRTPHLILSSSSQRPVIYQWSKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Rattus_norvegicus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESESIRRMGN----ACIPLKRIAYFLCLFSVVLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CSKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEVLKIRKPNDIE
TFKIED------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIARP-------PLTLRTPHLILSSSSQRPVIYQWSKA------TQLFINQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Oryctolagus_cuniculus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSQRMGN----ACLPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLSHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFLDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Canis_familiaris_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Felis_catus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Bos_taurus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------SLLHWSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLSHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------IQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Equus_caballus_LGI1
--------------------------------------------------------------------------------
-------------------------------------------------------------------------------M
QDGSLLQQLDPSHLAAPHRSLPRAVHCWSEEQLTNQLQVPVLKSRDTEAKEKGGLLCDLV----LEQDNHHLNSRSPVHV
WGYFFDCMESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIARM-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFINQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Loxodonta_africana_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MEAERSQRMGN----ACVPLKRIAYFLCLLSALLLT---EGKKPTKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLDHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYL--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEILKIRKPNDIE
TFNIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGASFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDADKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Dasypus_novemcinctus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSQRMGN----ACIPLKRIAYFLCLFSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLT-V---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLDHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVIADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQTLRTPHLILSSSSQRPVIYQWNKA------MQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFLDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Myotis_lucifugus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCESP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQEL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFNGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDGFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQALRMPHLILSSSSQRPVIYQWNKA------TQLFTNQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Pteropus_vampyrus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------KESERSQRMGN----ACIPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSSKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDTFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YD-ITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQALRTPHLILSSSSQRPVIYQWNKA------TQLFINQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFTRVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Monodelphis_domestica_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------MNFSGLGL----RARQSPSESRSFLFML
GEIFFNWMEAEKIKRMGSPSSASSIPLKRIAYFLCFLSMLLLT---EGKKPTKPK-------------------------
--------------CPALCT-CTKDNALCENARS--IPRSVPPDVISLSFVRSGFTEILEGSFLLTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHSFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLDTT-------NATVEEIYCENP
PEYKKRKIRSLSSKDFDCIIT---------------------------------------------------EFAASQLL
PYQSLS-IDTFTYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTVYKWNGN-----------------------------
--GFYSHQSLHQWYRDTDVEYLEIART-------PQTAKTPHLILSSSSQRPVIYQWNKS------TKLFTNQTDIPNME
DVYAV-KHFTVKGEVYICLTR---FIGDSKVMKW--GGSSFVDVQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---IQAPRSFTHVAIN-----------------------
------KHNFLFASSFKGRTQIYTHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Erinaceus_europaeus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------MESERSQRMGN----ACMPLKRIAYFLCLLSALLLT---EGKKPAKPK-------------------------
--------------CPAVCT-CTKDNALCENARS--IPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFD
VISDDAFIG---------------------------LPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNSFNCDCKLKWLVEWLGHT-------NATVEDIYCEGP
PEYKKRKINSLSPKDFDCIIT---------------------------------------------------EFAKSQDL
PYQSLS-IDVFSYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEKTFRN-YDNITGT---------
----------STVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFAN---------------KFIKIQDIEILKIRKPNDIE
TFKIEN------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIART-------PQILRTPHLILSSSSQRPVIYQWNKA------TQLFINQTDIPNME
DVYAV-KHFSVKGDVYICLTR---FIGDSKVMKW--GGSSFQDIQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYNWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQEIN---VQAPRSFTHVSIN-----------------------
------KRNFLFASSFKGNTQIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Gallus_gallus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------MGN----ASRPFRRIAYFLCLLSVLLLT---EGKKPVKPK-------------------------
--------------CPAWCT-CTKDNALCENARS--IPRSVPPDVISLSFVRSAFTKIPEGSFLLTPSLQLLLFTSNTFD
VISDDAFMG---------------------------LPHLEYLFIENNSIKSISRNTFRGLKSLIHLSLANNNLQSLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNAFNCDCKLKWLVEWLGST-------NATVEDIYCESP
PEYKKRKINSLSSKEFDCIIT---------------------------------------------------EFEVFQSL
PYQSLS-VDTFSYM--NDEHVVIAQ------------PFTGK-CIFLEWD-----HVEVMFRN-YDNITGT---------
----------STVVCKPIVIESQLYVIVAQLFGGSHIYKRDIFAN---------------KFIKIQDIEILKIRKPNDIE
TFRIAE------------------DWYFVVADSS----KAGFTTVYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEFLEIA-------------GKPHLILSSSSQRPVIYQWNKG------TNEFVKRFDIQDME
DAYAV-KHFKVKEDVYICLTR---FIGDSKVMKW--GGSAFLDLQRMPSRGS----MVFQPLQIRNYQYAILGSDYSFTQ
VYYWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---IQAPRSFIHVSID-----------------------
------KRDFLFASSFKGTTLIYKHVRVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Taeniopygia_guttata_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------LERERIKRMGN----ASKPFRRIAYFLCLLSVLLLT---EGKKPVKPK-------------------------
--------------CPAWCT-CTKDNALCENARS--IPRSVPPDVISLSFVRSAFTKIPEGSFLLTPSLQLLLFTSNTFD
VISDDAFMG---------------------------LPHLEYLFIENNNIKSISRNTFRGLKSLIHLSLANNNLQSLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNAFNCDCKLKWLVEWLGST-------NATVEDIYCESP
PEYKKRKINSLSPKEFDCIIT---------------------------------------------------EFEVYQSL
PYQSLS-VDTFSYM--NDEHVVIAQ------------PFTGK-CIFLEWD-----HVEVMFRN-YDNITGT---------
----------STVVCKPIVIESQLYVIVAQLFGGSHIYKRDIFAN---------------KFIKIQDIEILKIRKPNDIE
TFRIAE------------------DWYFVVADSS----KAGFTTVYKWNGN-----------------------------
--GFYSHQSLHAWYRDTDVEYLEIS-------------GKPHLILSSSSQRPVIYQWNKG------TNEFVKRFDIQDME
DAYAV-KHFKVKEDVYICLTR---FIGDSKVMKW--GGSAFLDLQRMPSRGS----MVFQPLQINNYQYAILGSDYSFTQ
VYYWDAEKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---VQAPRSFIHVSID-----------------------
------KRDFLFASSFKGTTLIYKHVIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Anolis_carolinensis_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------MGS----ASRALQRGG-LLCLLGVLLLLS--EGSRSGKTT-------------------------
--------------CPAWCT-CTKDNALCENARF--IPRSVPPDVTSLSFVRSAFTKIPERSFVFSPSLQLLLFTANNFD
VISGDAFLG---------------------------LPHLEYLFIENNNIKSLSNTSFRGLKSLIHLSLANNNLQTLPKD
IFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNAFKCDCKLKWLVAWVSRT-------NATIEDIYCESP
PEYKKRKINAISPTEFDCIIT---------------------------------------------------EFVVFRKL
PYQSLS-VESFSYL--NDEYVVIAQ------------PFIGK-CIFLQWD-----HVEGTFRN-FDNITGI---------
----------SVVVCKPVIVDNRLYIIVAQLFGGSHIYKRDIHAN---------------KFIKIQDIEILKIRKPNDIE
TFSIAE------------------DTYFAIADSS----KAGITTVYKWNGN-----------------------------
--GFYSDQSLHEWYRDTDVEYFEIS-------------GKPHLILSSSSQHPVIYQWSKG------TSNFIDPVDIPDME
DVYAV-KHFKVKEDIYVCLTR---FIGDSKVMKW--GGSKFLDLQRMPSRGS----MVFQPLQIKNYQYAILGSDYSFTQ
VYFWDVGKAK----------------------------------------------------------------------
---------------------------------FVKFQELN---IQAPRSFTHVFVD-----------------------
------KKDFLFASSFKGNTMIYKHIIVDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Xenopus_tropicalis_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------KIQRMGN----GSGSSAWISFFISFSFVLLLINWSEGKRPAKSK-------------------------
--------------CPIWCT-CTKDNALCENAKS--IPRTFLPDVISLSFVRSEFTEIPEGSFLHIPSLQLLLFTSNAFD
AISDDAFTG---------------------------LPHLEYLFIENNKIKSISRNAFRGLKSLIHLSLANNNLQSLPKD
VFKGLDSLTNV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNAFHCDCKLKWLVEWLDKT-------NATVEQIHCESP
PEYKGRKINSLSAKDFDCITT---------------------------------------------------EFAAYKSL
PYQSLS-VDTFTYM--NDEYVVIAQ------------PFTGK-CIFLEWD-----HVEMSFRN-YDNITGT---------
----------STVVCKPIVIEKQLYVIVAQLFGGSHIYKRDIFAN---------------KFIKIQDIEILKIRKPNDIE
TFRIDE------------------NWYFVVADSS----KAGFTTIYKWNGN-----------------------------
--GFYSHQSVHAWYRDTDVEFLEMTN-------------KPHLILSSSSQRPIIYQWNKK------SNEFAKHTEIPDTE
DVYAV-KHFTVKDDVYLCLTR---FIGDSRVIKWE-GGSDFREIQRMPSRGS----MVFQPIEINNHKYAILGSDYSFTQ
VYHWDSEKGM----------------------------------------------------------------------
---------------------------------FVKFQELN---IQAPRSFTHVSID-----------------------
------KRDFLFASSFKGTTQIYEHVIIDLSA------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Danio_rerio_LGI1a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------MGYANRSIRAYTF-LLWVAAVLLFA--ESRRGKQPR-------------------------
--------------CPSGCT-CTKDNALCENVRS--VPHSFPPDVISLSFVKSGFSEIAGGSFLHTPSLQLLLFTANSFD
LIDEDAFQG---------------------------LPHLEYLFIENNKIESISPHAFRGLKSLIHLSLAYNNLETLPRD
IFKGMDALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNLFSCDCKLKWLVEWMFST-------NATVDQLYCSGP
SPYQGKKINDLMPQSFDCITA---------------------------------------------------EFALKKTL
AFESIS-VEAFSYG--NDQYVVYAQ------------PFTGR-CNFMEWD-----HVNMEFRD-HEIILST---------
----------STVVCKPMVIDDHLFIVVAQLFGGSHIYKRDSSAN---------------KFIKIQDIDILKIRKPNDIE
TFRVDG------------------EFYFVIADSS----KAGSTTVYKWNGN-----------------------------
--GFYSHQSLHPWYRDTDVEYLEIA-------------GKPHIILSSSSQRPVVYQWSRS------QKQFDRRTDIPDME
DVYAV-KHFKVKGELFICLTR---FIGDSKVMKW--DGAMFIEIQTMPSRGS----MVFQPVSIGNWQYAILGSDYSLTQ
VYQWDAKKSQ----------------------------------------------------------------------
---------------------------------FVHFQELN---VQAPRAFSLASID-----------------------
------NREFLLASSFKGKTQIYEHLMIDLSS------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Danio_rerio_LGI1b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------MMCLRRAAVLCVLLAALVLG-----GRRRSSR-------------------------
--------------CPAPCT-CSKDNALCANTGA--IPRSFPQDVISLSFVKSGFTEIPKESFIHTPALHLLLFTANSFD
SINEDAFLG---------------------------LPHLEYLFIENNQIKSISPFAFRGLKSLIHLSLAYNNLETLPKD
LFKGMEALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNLFSCDCKLKWLVDWMFHT-------NATVDQIFCNGP
EGYQGKKINDLEAQTFDCITT---------------------------------------------------DFTLLKSL
EFQSIS-VEAFSFA--GDQFVVFAQ------------PFSGR-CSFMEWD-----HVQMEFRN-FDNITST---------
----------STVICKPLVIDSQLFIIVAQLFGGSHIFKRDVSAN---------------KFIRIQDIDILKIRKPNDVE
IFEVDG------------------ESFFIIADSS----KAGSTTIYKWNGN-----------------------------
--GFYSYQSLHPWHRDTDVEYLDIS-------------GKPHLILSSSSQRPVVYQWSRG------SAQFERRTDIPEME
DVFAV-KHFTVKNELYICLTR---FIGDSKVMRW--DGSMFTEIQTVASRGS----MVFQPFSVASWQYAILGSDYAFTR
VYRWDAKKRQ----------------------------------------------------------------------
---------------------------------FVPFQELN---IQAPRAFSLVFID-----------------------
------NREFLLGSSFKGQTRIYEHLVLDLSS------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Takifugu_rubripes_LGI1a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------EGMGLSDRGWRGRTLPFLVIAVSVISA--DGLRVRQPR-------------------------
--------------CPFGCT-CTKDNALCENVRS--VPHTFPPDVVSLSFVKTGFSGITGGSFVHTPVLQLLLFTGNSFD
FIDEDAFMG---------------------------LPHLEYLFIENNKIASISPNAFRGLKGLLHLSLAYNNLETLPRD
VFSGMEALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNNLICDCKLKWLVEWMHHT-------NATLDEIYCSGP
PSYQGKRLNDLLPHSFDCITS---------------------------------------------------EFASYQSL
KFESIS-VEAFTFG--MDQYVVFAQ------------PFAGT-CNFLEWD-----HVEMTFRT-YDTIEST---------
----------STVVCKPMVIDNHLFVIVAQLFGGSHIYKRDVSAN---------------KFIKIQDIDILKIRKPNDIE
TFMIEG------------------ESYFVIADSS----KAGSTTVYKWNGN-----------------------------
--GFYSHQSLHHWYRDTDVEYLVIS-------------NKAHLILSSSSQRPVIYQWNRS------QKQFERRTDIPDME
DVFSV-KHFHVKGELFICLTR---FIGDSKVMRW--DGAMFKELQTFPSRGS----MVFQPVSIGKWQYAILGSDYSLTQ
VYQWDAKKGQ----------------------------------------------------------------------
---------------------------------FVPSQELN---IQAPRSFSVLFVD-----------------------
------SRVFLLASSFKGKTQIYEHLIIDLSNSTF---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Takifugu_rubripes_LGI1b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------VQDFCLASMENSPKMPMRSTWLFSLVVASVFLAV--VVGKPKQPR-------------------------
--------------CPTHCT-CTKDNALCQSADI--IPRSFPREVTSLSFANSKFTEIPKESFIHSPGLHLLLFTANNLE
SINEDSFLG---------------------------LPHLEYLFIENSQIQTISPNAFNGLKTLVHLSLAFNNLETLPKD
LFRGLEALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNQFACDCKLKWLVEWIYST-------NATVDQIYCKGP
ASQLDKKINSLLPQSFDCITT---------------------------------------------------EFASYQSL
DFKTLS-VEAFSFG--NDQYVVFAQ------------PFNGK-CTFLEWD-----HVEMVFRK-YDEINST---------
----------STVICKPLVIDDQLFVIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILKIRKPNDVE
TFRIDG------------------ESFFIIADSS----KAGSTTIYKWNGN-----------------------------
--GFYSHQSLHPWYRDTDVEYMEIS-------------SKPHLILSSSSQRPVIYQWNKG------TKQFERRTDIPEME
DVYAV-KHFHVKSDLFICLTR---FIGDSKVMRW--DGALFRELQTMPSRGS----MVFQPFTLGSWQYAILGSDYSFTQ
VYRWDAKKGE----------------------------------------------------------------------
---------------------------------FVQFQEVN---IQAPRAFSPVSID-----------------------
------NRQFLLASSFKGKTQIYGHLVIDLSN------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Tetraodon_nigroviridis_LGI1a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------MGLPGRGWRGRTL-VLVVAVSVISA--DGWRVRQPR-------------------------
--------------CPYGCT-CTKDNALCENVRS--VPHTFPPDVVSLSFVKTGFSGITGGSFVHTPVLQLLLFTGNSFE
FIDEDAFMG---------------------------LPHLEYLFIENNKIASISPYAFRGLKGLLHLSLAYNNLETLPRD
VFSGMEALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNNLICDCKLKWLVEWMHQT-------NATLDEIYCSAP
PVYQGKRLNDLLPHSFDCITA---------------------------------------------------EFASYQSL
KFESIS-VEAFTFG--MDQYVVFAQ------------PFAGT-CNFLEWD-----HVEMTFRT-YDTIEST---------
----------STVVCKPMVIDNHLFVIVAQLFGGSHIYKRDVSAN---------------KFIKIQDIDILKIRKPNDIE
TFTIEG------------------ESYFVIADSS----KAGSTTVYKWNGN-----------------------------
--GFYSHQSLHHWYRDTDVEYLVIS-------------NKAHLILSSSSQRPVVYQWNRS------QKQFERRTDIPDME
DVFSV-KHFHVKGELFICLTR---FIGDSKVMRW--DGAMFRELQTFPSRGS----MVFQPISIGKWQYAILGSDYSLTQ
VYQWDAKKGQ----------------------------------------------------------------------
---------------------------------FVPSQELN---IQAPREFSVLSVD-----------------------
------NRVFLLASSFKGKTQIYEHLIIDLSNSTF---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Tetraodon_nigroviridis_LGI1b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------LQDFCLAGLGNLPKMPTRSPRLFLLVLASVLLAV--VIGKPKQPR-------------------------
--------------CPTHCI-CTKDNALCQSADI--IPRSFPREVTSLSFANSKFTEIPKESFIHSPGLHLLLFTANNLE
SINEDSFLG---------------------------LPHLEYLFIENSQIQSISPNAFNGLKTLVHLSLAFNNLETLPKD
LFKGLEALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNQFICDCKLKWLVEWIDST-------NATVDQIYCKGP
ASQLDKKINSLVPQAFDCITT---------------------------------------------------EFASYQSL
DFKTLS-VEAFSFG--SDQYVVFAQ------------PFNGK-CTFLEWD-----HVEMVFRK-YDEINST---------
----------STVICKPLVIDNQLFIIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILKIRKPNDVE
TFRIDG------------------ESFFIIADSS----KAGSTTIYKWNGN-----------------------------
--GFYSHQSLHPWYRDTDVEYLEIS-------------SKPHLILSSSSQRPVIYQWNKG------AKQFERRTDIPEME
DVYAV-KHFHVKSDLFICLTR---FIGDSKVMRW--DGALFRELQTMPSRGS----MVFQPFILGSWQYAILGSDYSFTQ
VYRWDAKKGQ----------------------------------------------------------------------
---------------------------------FVQFQEVN---IQAPRAFSPVSID-----------------------
------NRQFLLASSFKGKTQIYEHLVIDLST------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Gasterosteus_aculeatus_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------KTQRES----DALLLGLLLMLMARNVLLAV--DSKRVRPPR-------------------------
--------------CPSSCT-CTKDNALCESAGL--IPRSFPPDVISLSFVKSEFTEIPKESFIHTPALHLLLFTANNLE
SINEDAFLG---------------------------LPHLEYLFIENNQITSISPYAFRGLKTLVHLSLAYNNLETLPKD
LFKGLEALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNQFTCDCKLKWLVEWMYST-------NATVDQIYCKGP
AAQLDKKINDLVPLSFDCITT---------------------------------------------------EFASYQSL
KFESIS-VEAFSFG--NEQYVVFAQ------------PFIGK-CSFLEWD-----HVEMVFRS-FDDIDST---------
----------STVICKPLVIDNQLFVIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILKIRKPNDVE
TFRIDG------------------ESFFVIADSS----KAGSTTIYKWNGN-----------------------------
--GFYSHQSLHPWYRDTDVEYMEIS-------------SKPHLILSSSSQRPVIYQWNKT------TKLFDRRTDIPEME
DVYAV-KHFQVKSDLFICLTR---FIGDSKVMRW--DGALFRELQTMPSRGS----MVFQPFSVGSWQYAVLGSDYSFTQ
VYRWDAKKGE----------------------------------------------------------------------
---------------------------------FVHFQEVN---IQAPRAFSPISID-----------------------
------NRQFLLASSFKGKTQIYEHLVIDLSD------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Oryzias_latipes_LGI1a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------LCPQRFARMGITAKRSQWLGVLAAASLLLLV--GSKRARQPR-------------------------
--------------CPLSCT-CTKDNALCEGAGS--IPRSFPPDVMSLSFVKSEFTEIPKESFIHTPGLHLLLFTANILE
SINEDAFIS---------------------------LPHLEYLFIENNQINSISPHAFRGLKTLVHLSLAYNNLETLPRD
LFRGLDALTKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNHFTCDCKLKWLVEWIFST-------NATVDQVYCKGP
ASHLDKSINDLEPQSFDCITT---------------------------------------------------ELASHQSL
KFESIS-VEAFFFE--NNQYVVFAQ------------PFIGK-CSFLEWD-----HVEMLFRTRYDDIDST---------
----------STVICKPLVIDNQLFVIVAQLFGGSHIYKRDSSAN---------------KFIKLQGIDILRIRKPNDIE
TFSIDG------------------ESFFVIADSS----KAGTTTIYKWNGN-----------------------------
--GFYSHQSLHPWYRDTDVEYLEIS-------------SKPHLILSSSSQRPVIYQWNRT------TKLFERRTDIPEME
DVYAV-KHFQVDSDLFICLTR---FIGDSKVMRW--DGALFREAQTMPSRGS----MVFQPFAVGSWQYAILGNDYSFTQ
VYRWDAKKGE----------------------------------------------------------------------
---------------------------------FVRFQELN---IQAPRAFSPVAID-----------------------
------NRQFLVASSFKGKTQIFEHRIIDLSN------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Oryzias_latipes_LGI1b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------------------------------------SLAYNNLDTLPRD
VFKGMDALNKV---------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------DLRGNNLICDCKLKWLVEWMHQT-------NATLDQIHCSGP
PNYQGRKINDLLPHSFDCITT---------------------------------------------------EFASYQPL
KFESIS-VEAFTFV--NEQYVVFAQ------------PFAGT-CSFLEWD-----HVEMTFRT-YDTIEST---------
----------STVVCKPMVIDHHLFVIVAQLFGGSHIYKRDSSAN---------------KFIKIQDIDILKIRKPNDIE
TFMING------------------ESFFVIADSS----KAGSTTVYKWNGN-----------------------------
--GFYTHQSLHPWYRDTDVEYLEIS-------------NKPHLILSSSSQRPVVYQWNRS------QKKFDRRTDIPDME
DVFSV-KHFWVKGDLFICLTR---FIGDSRVMRW--DGAMFREVQTFPSRGS----MVFQPVSVSNWQYAILGSDYSLTQ
VYQWDTKRGQ----------------------------------------------------------------------
---------------------------------FIPSQELN---IQAPRSFSVVSVD-----------------------
------DRVFLLASSFKGKSQIFEHHEIDLSD------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Ciona_intestinalis_LGI1
--------------------------------------------------------------------------------
------------------------------------------------------------------------------LS
LLCFMILFSTSYSSSTPSTIVSCPSPCTCSYKERLVNCSNRSLRKIPLIPPWVSILSLRNNKIEATAVKQHTFMNLPNLL
ELDLSDNELRTLSVSFSGSPLLRTLTLKQTKLKHVWLGMVSASGLCKAYSEIQMNWG-----------------------
-------LIAIFLIRINVTYITNIPYHRSHNIITTIDGLTEWPSLRVLDLSFNTIRGIRSNTFINQRNLTELYLHKNNIT
TVNEHAFAG--------------------------LVSLETLSDLSRNRINHIKGLAFNGMCQLRTLLLHGNRISNLKDA
SFYSLKALTTLRMDDN----------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------RIRSVDMGWLYDLKSLEKLSLSRNKVNSISSGAWKLCKEIRH
LNLSHNDLTTIISKQFESLTVMQT---------------------------------------------LDLSRNAIVAM
EKEAFYGLRKLKKLVLSRNLISSSVEDLG----GIFRGLDSIETLLMNNN-----RIRSLSPDTFVGADKLVYLDLRNNN
ITSVQNKTFQTMKNLKRLRINSAAFLCDCQLAWFSQWLRDSNINTRS------------EGNCRCFHPPKLKGRRVVNIG
SNEFECG---------------EHPIPTLLQQPSKLTAYKGENVTLECSASATL-----------------------TKN
VSNVKSSALMSVVWRRGRSKTLSHESQ-------KIRIRKPQRIEGGHIFFTSFLILYDVTYDSDDDYSCVISNEFGHAK
STPAAHLSVYVYPTITKQPEDRTVKSGSEVIFQCQASGHPIPDISWQKDGGS------SFPAAHERRLVRTQNAPLHISE
VQPKDAGVYTCTAKSVAG--------------------------------------------------------------
----------------------VQSVSATLTVLYPPIVEKMPDKIEAVKGGNAVLKCMSSAN------------------
---PAPQVTWLLNGGVLNGTTRHFFAAGDQLLVIVNFSSLDQGEYACSV-------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------
>Ciona_savignyi_LGI1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------NRIQIIPSFSFSSYPQLRRIDLSNNEIK
EIERDAFDG---------------------------LSQLSSLVMYGNKITSLPAGIFTHMHNLQMLLMNANKIKCLRQD
VFSGLRSLTLLSLYDNKLQSISRGTFANLRSIET----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------------------------------INLLSNPLDCNCHLSWLSTWLRRS-------PVSSGNPRCAEP
RFLREFPVADINPRDFRCSTEQEARAAPTCLP-VQKCPEQCTCEGTIVRCANTGLTSVPVDDIPHDVTELYLEMNDIREI
P-ASIKKFIYLTTLDLSNNDISSIN-------DWMFSNLTRLSTLLLAYN--