>Homo_sapiens_HTRA1
------------------------------------------------MQIPRAALLP-------LLLLLLAAPASAQLS
RAGRSAPL----AAGCPDRCEPARCPPQPE-HCEGGRARDACGCCEVCGAPEGAACGL----QEGPCGEGLQCVVPF---
GVPASATVRRRAQAGLCVCAS---SEPVCGSDA-----------------------------------------------
----NTYANLCQLRAASRRSERLHRPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV
VR-RGNEDIMITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Pan_troglodytes_HTRA1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------------------QEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV
VR-RGNEDIMITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Gorilla_gorilla_HTRA1
------------------------------------------------MQIPRAALLPL------LLLLLLAAPASAQLS
RAGRSAPL----AAGCPDRCEPARCPPQPQ-HCEGGRARDACGCCEVCGAPEGAACGL----QEGPCGEGLQCVVPF---
GVPASATVRRRAQAGLCVCAS---SEPVCGSDA-----------------------------------------------
----NTYANLCQLRAASRRSERLQLPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV
VR-RGNEDIMITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Macaca_mulatta_HTRA1
------------------------------------------------MQIPRAALLPL------LLLLLLAAPASAQLS
RAGRSAPL----ATGCPERCEPARCPPQPE-HCEGGRARDACGCCEVCGAPEGAACGL----QEGPCGEGLQCVVPF---
GVPASATVRRRAQAGLCVCAS---NEPVCGSDA-----------------------------------------------
----NTYANLCQLRAASRRSERLHRPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKRE-STLNMV
VR-RGNEDIMITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Mus_musculus_HTRA1
------------------------------------------------MQSLRTTLLS-------LLLLLLAAPSLALPS
GTGRSAPA----ATVCPEHCDPTRCAPPPT-DCEGGRVRDACGCCEVCGALEGAACGL----QEGPCGEGLQCVVPF---
GVPASATVRRRAQAGLCVCAS---SEPVCGSDA-----------------------------------------------
----KTYTNLCQLRAASRRSEKLRQPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELYRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAVTKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVTANDVSDVIKKE-NTLNMV
VR-RGNEDIVITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Rattus_norvegicus_HTRA1
------------------------------------------------MQFLRTALLS-------LLLLLLAAPSLALPS
GISRSAPA----ATVCPEHCDPTRCAPPPT-DCEGGRVRDACGCCEVCGALEGAVCGL----QEGPCGEGLQCVVPF---
GVPASATVRRRAQAGLCVCAS---SEPVCGSDA-----------------------------------------------
----KTYTNLCQLRAASRRSEKLRQPPVIVLQRGACG------QGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELYRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHQGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKTVTKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVISGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVTANDVSDVIKKE-NTLNMV
VR-RGNEDIVITVVPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Canis_familiaris_HTRA1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------------GACG------EGQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHEGR-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDHHRDFP-----
-----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSASDVSDVIKKE-NTLNMV
VR-RGNEDIMITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Felis_catus_HTRA1
--------------------------------------------------------------------------------
-------------------------------------------HRPYLGLVMDG--------------------------
--------------------------------------------------------------------------------
----------------------------------FAG------QWQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHEGK-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKKE-STLNMV
VR-RGNEDIMITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Equus_caballus_HTRA1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------GQEDPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKHRVKVELKNGAT-----------------YEA
KIKDVDEKADIALIK--------------IDHEGN-----LPVLLLGRSSELR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTS----------------------SKAKELKDRHRDFP-----
-----------------DVLSGAYIIEVIPDTPAE---AGGLKENDVIISINGQ----SVVSANDVSDVIKKE-STLNMV
VR-RGNEDIMITVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Gallus_gallus_HTRA1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------XRRAERLRQPPIIAIQRGGCG------QGQEHPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPYSK-REIPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGET-----------------YEA
KIKDVDEKADIALIK--------------IDAQGK-----LPVLLLGQSGDLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAITKKKYIGIRMMSLTP----------------------SKAGELKDRHKDFP-----
-----------------DVVSGAYVIDVIPETPAE---AGGLKDNDVIISINGQ----SITSASDVSDIIKKD-STLNMV
VR-RGNEDVMLTVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Taeniopygia_guttata_HTRA1
--------------------------------------------------------------------------------
----------SALPACPERCDRSRCPALPA-GCPGGPVPDACGCCRVCGAEEGEACGG----AGPPCGEGLQCVLPPG--
AVPASATVRKRAAAGRCQCTS---SEPVCGSDA-----------------------------------------------
----VTYASHCQLRAASRRAESLRQPPIIAIQRGACG------QGQEHPNSLRHKYN-FIADVVEKIAPAVVHIELFRK-
--LPFSK-REVPVASGSG----FIVS-EDGLIVTNAHVV------TNKNRVKVELKNGET-----------------YEA
KIKDVDEKSDIALIK--------------IDSQGK-----LPVLLLGQSADLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIKKFLTESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKAVTKKKYIGIRMMSLTP----------------------SKARELKDRHKDFP-----
-----------------DVVSGAYVIEVIPETPAE---AGGLKDNDVIISINGQ----SISSASDVSDIIKKD-STLHMV
VR-RGNEDVMLTIVPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Danio_rerio_HTRA1a
----------------------------------------------------------------MRLLILCASIILVP--
LLCDARIIKRYVIG-CPERCDKSLCPPIPP-DCLAGDILDQCDCCPVCAAGEGESCGGTGKLGDPECGEGLECAVSD---
GVGATTTVRRRGKTGVCVCKS---SEPVCGSDG-----------------------------------------------
----VSYRNICELKRVSNRAQKLQQPPIIFIQRGACGK-----GHEENPDSLRHRYN-FIADVVEKIAPAVVHIELFRK-
--NVFN--REVAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKTGTT-----------------YDA
KIKDVDEKADIALIK--------------IDAPMK-----LPVLLLGRSADLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIRQFLAESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKTATKKKYIGVRMMTLTP----------------------TLAKELKQRKNDFP-----
-----------------DVTSGAYVIEVIPKTPAE---VGGLKESDVIISINGQ----RITSASDVSTAIKTD-ESLRAV
VR-RGNEDIILTIIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Danio_rerio_HTRA1b
---------------------------------------------------------------MILVTLFCICALVTS--
LQADARLSKRYVIGGCPSHCDKSMCPTMPK-DCSTGQVMDHCNCCLVCASGEGEACGGVGKLGDPVCGESLECSVTG---
GVSYSATVRRRGKQGVCVCKS---SDPVCGSDG-----------------------------------------------
----VSYRDICELKRVSNRAQSLQQPPVLFIQRGACGT-----SLHDNPNSLRYKYN-FIADVVEKIAPAVVHIELYRK-
--MVYSK-REMAVASGSG----FVVS-DDGLIVTNAHVV------ANKNRVKVELKNGAS-----------------YDA
KIKDVDEKADIALIK--------------IDLPNK-----LPVLLLGRSADLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIRQFLAESYDRLAR----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GRGTTKKRYIGVRMMTLTP----------------------SLSKELKGRLRDFP-----
-----------------DITSGAYVIEVISKTPAA---AGGLKEHDVIISINGQ----RISTATDVSAIIKKE-SSLRVV
VR-RGNEDIILTIIPMEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Takifugu_rubripes_HTRA1a
--------------------------------------------------------MFFMQLYMFWSLSLCVIAAFAP--
VPAYAQSSNRFVVG-CPSRCDKSMCPRPPA-DCAAGQTLDVCNCCPVCASGEGEACGSNGKLGDPVCGEGLECSVTG---
GVAYTITVRRRSKSGTCMCKS---SEPVCGSDG-----------------------------------------------
----VSYRNICELKRVSRRAQKLQQPPVLFIQRGACG------KAQNNPESPRHKYN-FIADVVERIAPSVVHIELFRK-
--MTYSK-REVPVASGSG----FVVS-EDGQIVTNAHVV------ANKHRVKVELKSGGS-----------------YDA
KIKDVDEKSDIALIK--------------IDTPVK-----LPVLLLGRSSDLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGRELGLRNS--------DMEYIQTDAIIN--YGNSGGPLINLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIREFLAESYDRQSR----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GRTTAKKKYIGVRMMTLTP----------------------ALSKELKTQHRDFP-----
-----------------DITSGAYVMEVIAKTPAA---IGGLKEHDVIISINGQ----RISSASDVSTAIKKD-NKLSIV
VR-RGNEDLILTVVPVEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Tetraodon_nigroviridis_HTRA1a
----------------------------------------------------RLISESFHSPIMRLGLLLCALAMLV---
--AEARIVKRLAIG-CPEKCDKSQCAPIPA-DCLAGDALDRCDCCPVCASGEGEQCGGSG---DRDCAEGMECLVAD---
GVEVSATVRKRGAAGLCVCTS---SEPVCGSDG-----------------------------------------------
----VSYRNICELKRVSNRAVKLQRPPVILIQRGACG------EGQQNPDSLRYKYN-FIADVVEKIAPAVVHIELYRK-
--TIFTK-REVAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------FDA
KIRDVDEKADIALIK--------------IDAPMK-----LPVLLLGRSADLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIRQFLAESHDRQAR----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GQTVQKKKYIGIRMMSLTP----------------------TLAKDLKERQSDFP-----
-----------------DVTSGVYVIEVISRTPAE---RAGLHEKDVIISINGE----PISLASDVSDAIKGG-DALRMV
VR-RGNEDVILTVVPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Tetraodon_nigroviridis_HTRA1b
-------------------------------------------------------VAQLPSANMFWWLSLCAVAALA---
---EAQSSGRFVVG-CPARCDKSTCPRPPA-DCAAGQTLDACRCCPVCASGEGEACGGTGKLGDPVCGDGLECSVPG---
GVAHSGTVRRRSRSGTCTCKA---SEPVCGSDG-----------------------------------------------
----VSYRNTCELRRASRRAQRLLQPPVLFVQRGACG------KAQDNPDSPRHKYN-FIADVVEKIAPSVVHIELFRK-
--MTYSK-REVPVASGSG----FVVS-EDGQIVTNAHVV------ANKHRVKVELQSGGS-----------------YDA
KIQDVDERSDIALIK--------------IAAPTK-----LPVLLLGRSSDLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGRELGLQNS--------DMDYIQTDAIIN--YGNSGGPLINLDG-----EVVGINT
LKVT----AGISFAIP-------------------------SDKIREFLAESYDRQSR----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GRTAAKKKYIGVRMMTLTP----------------------ALAKELKTQHRDFP-----
-----------------DITSGAYVMEVIAKTPAA---VGGLKEHDVIISINGQ----RISSASDVSAAIKKD-NKLSVV
VR-RGNEDLILTVVPVEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Gasterosteus_aculeatus_HTRA1a
---------------------------------------------------------------MSLRLVLCVMALLVRPP
PAAGARRAKRFAIG-CPEKCDVSVCAPIPA-DCPAGDALDHCDCCPVCASGEGEQCGGTA---RRECAEGMECAVTG---
GVEASATVRRRGAAGVCSCTS---SDPACGSDG-----------------------------------------------
----VSYRNICELKRVSNRAMKLRQPPVIFIQRGTCG------QGQQNPDSLRLKYN-FIADVVQKIAPAVVHIELYRK-
--MMFSK-REVAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------FDA
RIKDVDEKADIAVIE--------------IDAPMK-----LPVLLLGRSADLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DIDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVA----AGISFAIP-------------------------SDKIRQFLVESHARQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKTYQKNKYVGVRMMSLTP----------------------ALTKELKEKQSDFP-----
-----------------DITSGAYVIEVIGRTPAE---AAGLQEKDVIISINGE----PIASASDVSAAIRRD-DTLRTV
VR-RGNEDVLLSIVPEEIEP------------------------------------------------------------
--------------------------------------------------------------------------
>Gasterosteus_aculeatus_HTRA1b
--------------------------------------------------------------------------------
---------------------------MPA-HCPAGQILDACHCCQVCASGEGEACGGLGKLGDPVCGEGLECSVSA---
GVAYTTTVRRRSKSGTCACKS---AEPVCGSDG-----------------------------------------------
----VSYRNVCELKRVSRRAQKLQQPPVVLIQRGACG------KARDNPDSPRHKYN-FIADVVEKIAPSVVHIELFRK-
--MTYSK-REVAVASGSG----FVVA-EDGQIVTNAHVV------ANKHRVKVELKSGGT-----------------YDA
KIKDVDEKSDIALIK--------------IDVPTK-----LPVLPLGRSSNLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGRELGLRNS--------DMEYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIREFLAEAYDRLSR----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GRAAAKKKYIGVRMMTLTP----------------------SLAKELKTRHLDFP-----
-----------------DITSGAYVMEVIAKTPAA---VAGLKEHDVIISVNGQ----RISSATDVSAAVKRD-GSLRVV
VR-RGNEDAILTVVPMEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Oryzias_latipes_HTRA1a
---------------------------------------------------------------MQLRLPVCVTALFASSW
LLAEAQIVKRAAIG-CPERCDRSACAPVLQ-DCLSGDELDRCGCCPVCASGEGAPCGAPG---DQECVEGMECVVTD---
GVEASATVRRRARAGVCTCIS---TDPVCGSDG-----------------------------------------------
----VSYRNVCELKRVSSRATELQQPPVIFIQRGACG------KGQQSPDSLRYKYN-FIADVVEKIAPAVVHIELFRK-
--MVFSK-REVSVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------YDA
KIKDIDEKADIALIK--------------IDTPNK-----LPVLLLGRSADLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKILQFLAESHDRQAK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GKTLAKKKYIGVRMMSLTP----------------------TLAKELKARHPDFP-----
-----------------DLTSGAYVMEVIGRTPAE---AAGLKERDVIISINGE----HITSANDVSTTIKRE-QNLRMV
VR-RGNEDVMLTVIPEEIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Ciona_intestinalis_HTRA1
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------GAGNTGGNTRRGAFN-FVADVVQVAGPAVVHIERLVN-
--VPFTR-RAVAVSNGSG----FLVE-SNGLIITNAHVVG------NQSALNVKLQDGRE-----------------FEG
QVIGIDEARDIAAVK--------------INCTG------LPKIPLGTTRDLR------PGEWVVAIGSPLA--------
---LKNTVTAGI-----VSNMCRAGKELGLRDE---EK--RDMEYIQTDATIN--VGNSGGPLVNLDG-----EVIGINS
MMAS----AGIGFAIP-------------------------IDYVRDFLQQLEHGQQTRVQ-------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------HTRRWIGVSMLSLTP----------------------EISSHLRARNPDFP-----
-----------------DVTTGVYVHKVTPDSPSD---IAGVQNGDVIIKINGK----QINGVSDVLETLKQN-QVLNAS
IC-RRGRTIVVRIIAEEIVH------------------------------------------------------------
--------------------------------------------------------------------------
>Homo_sapiens_HTRA2
--------------------------------------------------------------------------MAAPRA
GRGAGWSLRA-WRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGV----TEPRACLTSGTPGP--
---------RAQLTAVTPDTRTREASENSGTRS-----------------------------------------------
----RAWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAA----VPSPPPAS-PRSQYN-FIADVVEKTAPAVVYIEILDR-
--HPFLG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA
VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSSG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLSP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEQ----MVQNAEDVYEAVRTQ-SQLAVQ
IR-RGRETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Gorilla_gorilla_HTRA2
--------------------------------------------------------------------------MAAPRA
GRGAGWSLRA-WRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVRV----TEPRACLTSGTPGP--
---------RAQLTAVTPDTRTQEASENSGTRS-----------------------------------------------
----RAWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAA----VPGPPPAS-PRSQYN-FIADVVEKTAPAVVYIEILDR-
--HPFLG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA
VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSSG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLSP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEQ----MVQNAEDVYEAVRTQ-SQLAVQ
IR-RGRETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Macaca_mulatta_HTRA2
--------------------------------------------------------------------------MAAPRA
GRGAGWSLRA-WRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLCVGV----PEPRACLTSGTPGP--
---------RAQLTAVTPDTRTREASENSGTRS-----------------------------------------------
----RAWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAA----VPGPPPAS-PRSQYN-FIADVVEKTAPAVVYIEILDR-
--HPFLG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA
VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSSG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLSP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGGQ----MVQNAEDVYEAVRTQ-SQLAVQ
IR-RGRETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Mus_musculus_HTRA2
--------------------------------------------------------------------------MAALKA
GRGANWSLRA-WRALGGIFWRKPPLLAPDLRALLTSGTPDSQIWMTYGTPSLPAQVPEGF----LASRADLTSRTPDL--
---------WARLNVGTSGSSDQEARRSPGSRR-----------------------------------------------
----REWLAV-AVGAGGA-VVLLLWG-WGRGLSTVLAA----VPAPPPTS-PRSQYN-FIADVVEKTAPAVVYIEILDR-
--HPFSG-REVPISNGSG----FVVA-SDGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA
MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQN--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-TSG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLTP----------------------SILIELQLREPSFP-----
-----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEK----LAQNAEDVYEAVRTQ-SQLAVR
IR-RGSETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Rattus_norvegicus_HTRA2
--------------------------------------------------------------------------MAALKA
GRGANWSLRA-WRALGGIFWRKGPLLAPDLRALLTSGTPDPQARMTYGTPSLPARVPLGV----LASRANLTSGTPDL--
---------WVRLTVGTPGSSDQEDCGSPGSRR-----------------------------------------------
----REWLAV-ALGAGGA-VLLLLWG-WGRGPSTVLAA----VPAPPPTS-PRSQYN-FIADVVEKTAPAVVYIEILDR-
--HPFSG-REVPISNGSG----FIVA-SDGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA
MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILGSPAH---RAGLRPADVILAIGEK----MIQNAEDVYEAVRTQ-SQLAVR
IR-RGPETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Oryctolagus_cuniculus_HTRA2
--------------------------------------------------------------------------MAALRA
GRGAGWSLWG-LRALGGIRWGKGPLLTSDLRALLTSGTPDLRARMTYGTPSLRARLAVGV----PEPRAFLTSGSPDP--
---------RPRLTAGAPDSRPREASGTPGTRP-----------------------------------------------
----RVWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VPAPPPTS-PRSQYN-FIADVVEKTAPAVVYIEILDR-
--HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA
MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILGSPAH---RAGLRPGDVILAIGEQ----LVQNAEDVYEAVRTQ-SQLAVR
IR-RGSETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Canis_familiaris_HTRA2
--------------------------------------------------------------------------MAALRA
GRGAAWNLRG-WRALGGVHSGKGPLLTPDLRALLTSGIPDPRARVTYGTPSLRARWSVGV----PEPRTCLTSRTSDS--
---------RAWLAVGTPDPRTQEGSGTPGTRP-----------------------------------------------
----RIWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VLGSPPSS-PRSQYN-FIADVVEKTAPAVVYIEILGR-
--HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA
VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR
IR-RGPETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Felis_catus_HTRA2
--------------------------------------------------------------------------MAALRA
GRGAGWNLWG-WRALGGVPWGKGPLLTPDLRALLTSGTPDPRARVTYGTPSLWARLSGGV----PEPRTCLTSGTSDS--
---------RARLTAGSPDLKTREVSETPGTRP-----------------------------------------------
----RIWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VLGSPPTS-PRSQYN-FIADVVEKTAPAVVYIEILGR-
--HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLLSGDT-----------------YEA
MVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR
IR-RGPETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Bos_taurus_HTRA2
--------------------------------------------------------------------------MAALRA
GRGAGWSLRG-WRALWGGRWGKGPLLTPDLRALLTSGTPDPRTRVTYGTPSFRARLSVGV----PEPRTCLRSRTSDL--
---------RARLIAGTPDPRTPEDSGTPGTRL-----------------------------------------------
----RVWLAV-ALGAGGA-VLLLFWG-GGRGPPAVLAS----VLGSPPTS-PRSQYN-FIADVVEKTAPAVVYIEILGR-
--HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA
VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPAKDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----SGISFAIP-------------------------SDRLREFLHRGEK-KNSWFG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR
IR-RGQETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Equus_caballus_HTRA2
--------------------------------------------------------------------------MAALRA
GQGAGWSLRG-WRALGGVRWGKGPLLTPDLRALLTSGTSDPRARVTHGTPSLQARLSGGV----PEQRTCLTSGTSDS--
---------RAQLTGGNPDPRTREDSGTPGTRP-----------------------------------------------
----RVWLAV-ALGAGGA-VLLLLWG-GGRGPPAVLAS----VLGSPPTS-PRSQYN-FIADVVEKTAPAVVYIEILGR-
--HPFSG-REVPISNGSG----FVVA-ADGLIVTNAHVV------ADRRRVRVRLPSGDT-----------------YEA
VVTAVDPVADIATLR--------------IQTK---EP--LPTLPLGRSADVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRPARDLGLPQT--------NVEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----AGISFAIP-------------------------SDRLREFLHRGEK-KNSSLG-ISG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SQRRYIGVMMLTLTP----------------------SILAELQLREPSFP-----
-----------------DVQHGVLIHKVILDSPAH---RAGLRPGDVILAIGEQ----LVQNAEDIYEAVRTQ-SQLAVR
IR-RGPETLTLYVTPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Anolis_carolinensis_HTRA2
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------------SPPPPR-----------------------------------------------
----WRWAAMGACGAGAGLLLLLFFP---RKPAEARPP----VPSPPPSP--RSTYN-FIADVVERTAPALVYIEILGR-
--HPFSG-REVPISNGSG----FVVS-SDGLIVTNAHVV------ANRRRVRVRLASGEL-----------------YDA
TVRLVDQVADIATLK--------------ISPK---KP--LPTLRLGRSSEVR------QGEFVVAMGSPFA--------
---LQNTITSGI-----VSSAQRGGRELGLSSS--------DIEYIQTDAAID--FGNSGGPLVNLDG-----EVIGVNT
MKVT----PGISFAIP-------------------------SDRLRAFLEKEEKSKDSWFGGKKE---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------GKRRYIGVMMLTLTS----------------------SILSELKMRDPSFP-----
-----------------DISYGVLIHKVIIGSPAH---QAGLKAGDVVVEINGR----ASRRAEDVYEAVRTQ-DHLTLL
VH-RGYEALLLTITPEVTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Danio_rerio_HTRA2a
-----------------------------------------------------------------------------MAT
SHVNRCLLRTITRCHRDSSRQLN-LTTVRALGHFSNFSSGKEEHVETVDPPRGSGGGSGT----SRLAVALGLGLGGA--
-----------AAVFSLRGEDNKDALQRTVAVK-----------------------------------------------
----NLLIDS---------------------ILPTVQC----ASPFKPDS-PRYKYN-FIADVVEKSTPAVVYIEIVGR-
--HPFSG-REVPISNGSG----FIVS-SDGLIVTNAHVV------ANKRGVRVKLTNGET-----------------YNA
TVQDVDQAADIATIK--------------INVK---NP--LPTLRLGKSSDVR------QGEFVVAMGSPFS--------
---LKNTITSGI-----VSSAQRGSKELGLSNS--------NMDYIQTDATID--FGNSGGPLINLDG-----EVIGINT
MKVT----AGISFAIP-------------------------SDRVRLFLDRSADKQNSWFG-ESGWKRRYIGVMMLTLTP
RHPFSGREVPISNGSGFIISSDGLIVTNGHVVANKCGVRVKLTNDETYNATVQDVDQAADIASIKINVKNPLPTLRLGKS
SDVRQGEFVVAMGSPFSLKNTITSGIVSSAQRGSKELGLSNSNMDYIQTDATIDFGNSGGPLINLDGEVIGINTMKVTAG
ISFAIPLFLDRSADKQKSWFGESESKRRYIGVMMLTLTP----------------------SIIKELRMRDPSFP-----
-----------------DVSHGVLIHRVIVGSPAN---RAGMKPGDVIIEINGV----KVNTSEEIYNAVRTS-ESLNVV
VR-RGADLLMLHMTPESTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Danio_rerio_HTRA2b
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------------------------------------------------------------LFR-
--HPFSG-REVPISNGSG----FIIS-SDGLIVTNAHAV------ANKRGVRVKLTNGET-----------------YNA
TVQDVDQAADIATIK--------------INVK---NP--LPTLRLGKSSDVR------QGEFVVAMGSPFS--------
---LKNTITSGI-----VSSAQRGSKELGLSNS--------NMDYIQTDATID--FGNSGGPLIHLDG-----EVISINT
MKVT----AGISFAIP-------------------------SDRVRLFLDRSADKQNSWFG-ESG---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------SKRRYIGVMMLTLTP----------------------SIIDELRMRDPSFP-----
-----------------DVSHGVLIHRVIVGSPAN---RAGMKPGDVIIEINGV----KVNTSEEIYNAVRTS-ESLNVV
VR-RGADLLMLHMTPESTER------------------------------------------------------------
--------------------------------------------------------------------------
>Takifugu_rubripes_HTRA2a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------PDS-PRYKYN-FIADVVEKSTPAVVYIEILGR-
--HPFSG-REVTVSNGSG----FLIS-TDGLIVTNAHVV------ANKRGVRVKLNNGEM-----------------YNA
TVQDVDQVADIATIK--------------ISVK---NP--LPTLPLGCSAQVR------QGEFVVAMGSPFA--------
---LRNTITSGI-----VSSAQRGSKELGLSNT--------NMDYIQTDAAID--FGNSGGPLINLDG-----EVIGINT
MKVT----AGISFAIP-------------------------SDRLRLFLDRAEQKKSSWFR-DSD---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------TRRRYIGVMMLTLTP----------------------SIIAELKLRDPSFP-----
-----------------EVTHGVLIHRVIMGSPAN---RAGMIPGDIVVEINGA----KANTSEEVYEAVRSS-DHISML
VQ-RGGELLQLRVTPEYTE-------------------------------------------------------------
--------------------------------------------------------------------------
>Takifugu_rubripes_HTRA1b
---------------------------------------------------------------MRLWVVLCATVLLA---
--AEARIVKRLAIG-CPDKCDKSQCAPVPA-DCLAGDVLDRCDCCPVCGAGDGEQCGGTD---DRECAEGLECLVTD---
GVEVSATVRRRGTAGMCVCTS---SQPVCGSDG-----------------------------------------------
----VSYRNICELKRVSNMAVKMQRPPVIFIQRGACG------EGQQNPDSLRYKYN-FIADVVEKIGPAVVHIELYRK-
--MMFTK-RELAVASGSG----FVVS-EDGLIVTNAHVV------ANKHRVKVELKSGAT-----------------FDA
KVRDIDEKADIALIK--------------IDAPTK-----LPVLLLGRSADLR------PGEFVVAIGSPFS--------
---LQNTVTTGI-----VSTTQRGGKELGLRNS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDKIRQFLAESHDRQSESNGRFQHFHPFPSS--------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------GQTTTQKKFIGIRMLSITP----------------------TLAKELKEKQPDFP-----
-----------------DVTSGVYVIEVISRTPAA---RAGLQDKDVIISINGE----QISSSSDVSEIIKTG-SVLRTV
VR-RGNEDVILTIIPEEMEP------------------------------------------------------------
--------------------------------------------------------------------------
>Gasterosteus_aculeatus_HTRA2a
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------------------------------PDS-PRFKYN-FIADVVEKSTPAVVYIEIVGR-
--HPFSG-REVPVSNGSG----FIIS-SDGLIVTNAHVV------ANKKGVRVKLTNGET-----------------YNA
TVKDVDPVADIATIK--------------ISAK---SP--LPTLALGRSSDVR------QGEFVVAMGSPFS--------
---LRNTITSGI-----VSSVQRGSKELGLSNS--------NMDYIQTDAAID--FGNSGGPLINLDG-----EVIGINT
MKVT----PGISFAIP-------------------------SDRLTLFLDQAAKKKNSRSG-ESA---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------TKRRYIGVMMLTLTP----------------------SIISELKLRDRSFP-----
-----------------DVAYGILIHRVILGSPAD---RAGMLPGDVVVEINGV----KVNTSEEIYQAVRSG-DKITTV
VQ-RGHQLLRLQITPESTEP------------------------------------------------------------
--------------------------------------------------------------------------
>Oryzias_latipes_HTRA2a
-------------------------------------------------------------------------MAVSAAV
RKCFVSALVTQARCQRLNALPKNTFSRASSAVTCGHGEPTGRKSLYDRAEAEGDSGQSGG----SVLWTSLGLGLCGA--
-----------AFL-----DSQKDKGVRGDSKS-----------------------------------------------
----RRFLEL---------------------LLPSAHC----ASPFKPDS-PRFKYN-FIADVVEKSTPAVVYIEILGR-
--HPFSG-REVPVSNGSG----FIIS-SDGLIVTNAHVV------ANKRGVRVKLTNGDM-----------------YHA
SVQDVDPVADIATIK--------------ITTKDVQNP--LP-IETGQSSDIR------QGEFVVAMGSPFA--------
---LRNTITSGI-----VSSAQRDSKELGLSNP--------NMEYIQTDATID--FGNSGGPLINLDG-----EVIGINT
MKVT----AGISFAIP-------------------------SDRLKIFLDQAAKKTKSSVG-ESR---------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------TKARYIGVMMLTLTP----------------------SIITELQLRDPMFP-----
-----------------NVTHGILIHRVIIGSPAS---RAGMLAGDIVVEINGV----KVNTSEEIYKAVRSS-DRITML
VQ-RGKELLRLQVTPEFIDP------------------------------------------------------------
--------------------------------------------------------------------------
>Branchiostoma_floridae_HTRA2
---------------------------------------------------------------------MTRTGFYLR--
----------------------TCSTS--VGNNTSKGYK--YLRDSGIVVGCFAWGYVIG---------KFG--------
-------------------------------VP-----------------------------------------------
----YIWPSTDSADKEKSS--IVKKVDAAEPFYGGEGYG---------GIPRSKQFN-FIADVVEIASPAVVYIEIQGKN
--PFTGG-RA-PTSNGSG----FIVR-EDGLVVTNAHVVAN--KRY----VKVRLQDGRL-----------------LDG
VVTLVDQAADIAAVKI-------------INCNTP-----LKTVKLGNSSTLR------PGEWVVAMGSPLS--------
---LSNTITAGV-----ISSVQRGSRELG-----LR-H--NDMDYIQTDAAIN--FGNSGGPLVNLDG-----EVIGVNT
MKVT----TGISFAIP-------------------------IDKVKEFLKNVEEKEKAQKG-WFGR--------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------GQVAPPSPPKRRYLGVTMVTLTP----------------------NIIMELQERRTDFP-----
-----------------DVRTGVLVHRIIVGSPAY---SAGIRPGDVITSINGR----QVTSARDIYDAVNS-GQQLNIT
CH-RGRTVHHLQVTPEEAD-------------------------------------------------------------
--------------------------------------------------------------------------
>Drosophila_melanogaster_HTRA2
--------------------------------------------------------------------MALRGSHRLEVI
FKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFS--------------------
------------------------------LGA-----------------------------------------------
----VVSAAIIQREDLT--------PTIAA--SKMTG--------------RRRDFN-FIADVVAGCADSVVYIEIKDTR
HFDYFSG-QPITASNGSG----FIIE-QNGLILTNAHVVIN--KPHT--MVQVRLSDGRT-----------------FPA
TIEDVDQTSDLATLR--------------IQVNN------LSVMRLGKSSTLR------SGEWVVALGSPLA--------
---LSNTVTAGV-----ISSTQRASQELG-----LR-N--RDINYLQTDAAIT--FGNSGGPLVNLDG-----EAIGVNS
MKVT----AGISFAIP-------------------------IDYVKVFLERAAEKR--KKGSAYKT--------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------GYP-VKRYMGITMLTLTP----------------------DILFELKSRSQNMPS----
-----------------NLTHGVLVWKVIVGSPAH---SGGLQPGDIVTHINKK----EIKNSSDVYDALADNSKTLDIV
IL-RGVKQMHVTITPEDP--------------------------------------------------------------
--------------------------------------------------------------------------
>Apis_mellifera_HTRA2
----------------------------------------------------------------------------MAAP
LTRTSWTVLRRNHFQYKQFLTVSCVNR-FSQYKYSHQQDKKFRTSEKTVRNVLFYTIFFS--------------------
------------------------------GFG-----------------------------------------------
----YVLYKWKDDCQNRFSNLIKSMFTIYAKPVSWDGG------------NNRNKYN-FIADVVEKSAPAVVYIEIQNNR
RFDFQTG-KPFNISNGSG----FIVE-SDGLILTNAHVVTA--KPHT--TVKVRLYDGSV-----------------YTG
TVEDIDVHSDLATVR--------------INKTN------LPVMKLGSSSNLR------PGEFVVAIGSPLA--------
---LSNTITSGV-----ISSVNRHSQELG-----LL-N--KQMAYIQTDAAIT--FGNSGGPLVNLDA-----EAIGINA
MKVT----SGISFAIP-------------------------IDYAKDFLRKAELRR-KNKGTQFAM--------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------EKT-KTQYIGITMLTLTP----------------------DLFYELQKKLKGIPH----
-----------------NIRYGVLVYKVIVGSPAH---LGGLQAGDIITQVNDE----PVVSSASIYKAIEA-AKILRMT
VI-RGLEVLHLRIEPEEI--------------------------------------------------------------
--------------------------------------------------------------------------
>Anopheles_gambiae_HTRA2
------------------------------------------------------------------MHCALR---RPALF
LQRRLLAVVQLAPHNNLRAFGGTGEHG--RSDG-SGEHSDSWSAQKAGLTATLALAGMFG--------------------
------------------------------LLA-----------------------------------------------
----YNTRPDQSKRKATGWPAFGFLPTVSAKTSATAG--------------NRQQYN-FIADAVEISAPAVVFIEIRDRQ
RVDFFTR-EPVTVSNGSG----FIIE-RDGLILTNAHVVVS--KPHT--LVTVRLTDGRT-----------------FPG
QVEHVDPTSDLATVR--------------IRCDN------LPTLRLGSSADLR------PGEWVVALGSPLA--------
---LNNTVTAGV-----VSSTQRASQELG-----LR-G--KDINYIQTDAAIT--FGNSGGPLVNLDG-----EAIGINS
MKVT----SGISFAIP-------------------------IDHAKAFLRKIHETAGTAGGRRLSS--------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------GAPSYRRYIGITMLSLTP----------------------DILHELQQRNHNFPP----
-----------------TVRGGVLVWKVIQGSPAH---SGGLQPGDIITHINGK----EINSSGDVYELLAAQEKKLAIT
IY-RGQQPATVHVFPEDTTA------------------------------------------------------------
--------------------------------------------------------------------------
>Homo_sapiens_HTRA3
-----------------------------------------------------------------------MQARALLLA
ALAALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC-------
------------VRGLCRCRW---SHAVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA
TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQREGRELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP-----
-----------------EVSSGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE
VR-RGNDDLLFSIAPEVVM-------------------------------------------------------------
--------------------------------------------------------------------------
>Pan_troglodytes_HTRA3
-----------------------------------------------------------------------MQARALLLA
ALAALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC-------
------------VRGLCRCRG---SHAVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA
TIKDIDKKSDIATIK--------------IHPK-----------------------------------------------
-------------------------------------------------------YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP-----
-----------------EVSSGIYVQEVAPNSPSQ---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------
>Gorilla_gorilla_HTRA3
-----------------------------------------------------------------------MPARALLLA
ALAALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC-------
------------VRGLCRCRW---SHAVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA
TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQREGRELGLQDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKDL--------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
----------------------ANWKKRFIGIRMRTITP----------------------SLVDELKASNPDFP-----
-----------------EVSSGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE
VR-RGNDDLLFSIAPEVVMDP-----------------------------------------------------------
--------------------------------------------------------------------------
>Pongo_abelii_HTRA3
------------------------------------------------------------------------------LA
QPLPARVTEEPPAAPASLAWSVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC-------
------------VRGLCRCRW---SHAVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDS-----------------YEA
TIKDIDKKSDIATIK--------------IHPKKK---P-TLCCCVGHSADLR------PGEFWWAIGSPFA--------
---LQNTVTTGI-----VSTAQRGGQGAGPPGT---P----TWDYIHCFLPLQ--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQTKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP-----
-----------------EVSSGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE
VR-RGNDDLLFSIAPEVVM-------------------------------------------------------------
--------------------------------------------------------------------------
>Macaca_mulatta_HTRA3
--------------------------------------------------------------------------------
------------------------------------------------------XCGSPL---DSPCGESLEC-------
------------VRGLCRCRW---THAVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLRQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIITNAHVVSSNNAASGRQQLKVQLQNGDS-----------------YEA
TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQREGRELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKQIKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLVDELKASNPDFP-----
-----------------EVSSGIYVQEVTPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLTE-SPLLLE
VR-RGNDDLLFSIAPEVVM-------------------------------------------------------------
--------------------------------------------------------------------------
>Callithrix_jacchus_HTRA3
-----------------------------------------------------------SPTPPPAAGPAAMQARALFLA
ALVALALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGGPL---DSPCGESLEC-------
------------VRGLCRCRW---THAVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------LGLHQLSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVTSRNTASGRQQLKVQLQNGDS-----------------YEA
TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGQSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQREGRELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITRFLTEFQDKHIKGKE-------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------LTYWKKRFIGIRMRTITP----------------------SLVDELKASNPDFP-----
-----------------GVSRGIYVQEVAPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAILNE-SPLLLE
VR-RGNDDLLFSIAPEVVIGP-----------------------------------------------------------
--------------------------------------------------------------------------
>Mus_musculus_HTRA3
-----------------------------------------------------------------MQARALLPATLAILA
TLAVLALAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGRPL---DSPCGDSLEC-------
------------VRGVCRCRW---THTVCGTDG-----------------------------------------------
----HTYADVCALQAASRRALQVSGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSSSTASGRQQLKVQLQNGDA-----------------YEA
TIQDIDKKSDIATIV--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVA----AGISFAIP-------------------------SDRITRFLSEFQNKHVKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLVEELKAANPDFP-----
-----------------AVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLADSSELQEAVLNE-SSLLLE
VR-RGNDDLLFSIIPEVVM-------------------------------------------------------------
--------------------------------------------------------------------------
>Rattus_norvegicus_HTRA3
-----------------------------------------------------------------MQARALLPATLATLA
TLAVSVLAREPPAAPCPARCDVSRCPSP---RCPGGYVPDLCNCCLVCAASEGEPCGRPL---DSPCGDSLEC-------
------------VRGVCRCRW---THTVCGTDG-----------------------------------------------
----HTYADVCALQAASRRALQISGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSSNTASGRQQLKVQLQNGDA-----------------YEA
TIQDIDKKSDIATIL--------------IHPNKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVA----AGISFAIP-------------------------SDRITRFLSEFQDKHVKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLVEELKTANPDFP-----
-----------------AVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLVDSSELQEAVLNE-SSLLLE
VR-RGNDDLLFSIMPEVVM-------------------------------------------------------------
--------------------------------------------------------------------------
>Canis_familiaris_HTRA3
--------------------------------------------------------------------------------
---------------------------------------------------------RLL---VSPCEKSVEC-------
------------ARGVFRCGW---AHPVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALELSGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSTNAVSGRQQLKVQLQNGDT-----------------YEA
TIKDIDKKSDIATIK--------------IHPKKK-----LPALLLGRSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVA----AGISFAIP-------------------------SDRITRFLTEFQDKHVKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLVEELKASNPDFP-----
-----------------SVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLADSSELQEAVLTE-SPLLLE
VR-RGNDDILFSISPEVVL-------------------------------------------------------------
--------------------------------------------------------------------------
>Felis_catus_HTRA3
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-------------QAASRRALQLSGTPVRQLQKGACP------SGLHQLTSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSTSNAVSGRQQLKVQLQNGDT-----------------YEA
TIKDIDKKSDIATIQ--------------IHPKKK-----LPALLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYVQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVA----AGISFAIP-------------------------SDRITRFLTEFQDRHAKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLLEELKASDPDFP-----
-----------------SVSSGIYVQEVVPNSPSQS--RGGIQDGDIIVKVNGR----PLADSSELQEAVLTE-SPLLLE
VR-RGNDDLLFSIAPEVVL-------------------------------------------------------------
--------------------------------------------------------------------------
>Equus_caballus_HTRA3
------------------------------------------------------------------------------LA
GLAALALATELPAAPCPASCDVSRCPSS---RCPGGYVPDLCNCCLVCAAGEGEPCGRPL---DSPCGESLEC-------
------------ARGVCRCRW---AHAVCGTDG-----------------------------------------------
----HTYANVCALQAASRRALQLSGTPVRQLQKGACP------SGLHHLTSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-EAGLIVTNAHVVSSTNSVSGRQQLKVQLQNGDT-----------------YEA
TIQDIDKKSDIATIK--------------IHPKKK-----LPALLLGHSGDLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVA----AGISFAIP-------------------------SDRITRFLTEFQDKHIKD---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------WKKRFIGIRMRTITP----------------------SLLEELKASNPDLP-----
-----------------TVSSGIYVQEVVPNSPSQ---RGGIQDGDIIVKVNGR----PLADSSELQEAVLNE-SPLLLE
VR-RGNDDLLFSIAPEVVV-------------------------------------------------------------
--------------------------------------------------------------------------
>Gallus_gallus_HTRA3
---------------------------------------------------------------MRLSLLSPLLLLCLSR-
--SRGSAELPAARAKCPTRCDVSKCPSP---SCPSGYVPDRCNCCLICAAGEGDSCGRKE---DPPCGDSLDCRYPMG--
---------KRFAKGVCQCKL---SVQVCGSDG-----------------------------------------------
----RTYDNICQLKAVSRKALQHGLPAVAQVQKGACES------GHLQSSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-DSGLIVTNAHVVSSTNAISGRQQLKVQLQNGDT-----------------YEA
TIRDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITQFLTESLDKQNK----------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
-----------------------DSKKRFIGIRMLTITP----------------------ALVEELKHNNADFP-----
-----------------DVRSGIYVHEVVPNSPSH---RGGIQDGDIIVKVNGR----PLMTSSDLQEAVMNE-SPLLLE
VR-RGNDDLLFNIEPEIVM-------------------------------------------------------------
--------------------------------------------------------------------------
>Taeniopygia_guttata_HTRA3
--------------------------------------------------------------------------------
-------------AKCPARCDVSTCPSP---SCPSGYVPDRCGCCLICAAGEGDSCGRKE---DPPCGDSLDCRYPMG--
---------KRFAKGVCQCKL---SAQVCGSDG-----------------------------------------------
----RTYDNICQLKAVSRKALQHGLPAVAQVQKGACES------GRSMSSSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIMS-DSGLIVTNAHVVSSTNAISGRQQLKVQLQNGDT-----------------YEA
TIKDIDKKSDIATIK--------------IHPKKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRITQFLTESHDKQSKG---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------KTDGKKRFIGIRMLTITP----------------------ALVEELKHSNADFP-----
-----------------DVRSGIYVHEVVPNSPSH---RGGIQDGDIIVKVNGR----PLLTSSDLQEAVMNE-SPLLLE
VR-RGNDDLLFNIEPE----------------------------------------------------------------
--------------------------------------------------------------------------
>Anolis_carolinensis_HTRA3
--------------------------------------------------------------------------------
----------PAGDRCPARCDVSRCPSS---ICPSGYVPDGCNCCLVCAAGEGEACGRAE---DPPCGEGLQCRSFNA--
---------EPERRGVCQCKL---GAAVCGSDG-----------------------------------------------
----RSYANACRLQTAARQALQQGRPPVRQVQKGACRAA---STGHQQLNSPRFKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-HNVPLSSGSG----FIMS-DTGLIVTNAHVVSSSSTVTGRQQLKVQLQDGDT-----------------YEA
KIKDIDKKSDIATIK--------------INPRKK-----LPALSIGQSGDLR------PGEFVVAMGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLKDS--------DMDYIQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVT----AGISFAIP-------------------------SDRIAQFLSENYDKKGNS---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------KIDGKKRFIGIRMLTITP----------------------VLMEELKVNNPDFP-----
-----------------DVISGIYVHEVVPNSPSQ---RGGIEDGDIIVKVNGR----PLKTSADLQDAVMNE-SPLLLE
VR-RGNDDLLFNIEPEVVIP------------------------------------------------------------
--------------------------------------------------------------------------
>Xenopus_tropicalis_HTRA3
--------------------------------------------------------ETPQLSELPISLLLRMKLCAWLPL
CALLTLLSGATRTGACPARCDVSRCPSP---ICPSGYVPDRCNCCLICAAGEGEPCGREG---DPPCGDSLQCKPPPG--
---------MRGLKGSCQCKH---TNPVCANDG-----------------------------------------------
----QTYDNLCQLKAASRRALQKGHSPVVLVQKGACQSA---SIGHQHPNSPRYKFN-FIADVVEKIAPAVVHIELFLR-
--HPLFG-RNVPLSSGSG----FIIS-DLGLIVTNAHVVSSSNTVSGRQYLKVQLHNGDS-----------------YEA
TIKDIDKKSDIATIK--------------IYPRKK-----LPVLLLGHSADLR------PGEFVVAIGSPFA--------
---LQNTVTTGI-----VSTAQRDGKELGLRDS--------DMDYVQTDAIIN--YGNSGGPLVNLDG-----EVIGINT
LKVA----AGISFAIP-------------------------SDRITKFMTESQDKKYKA---------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
---------------------NNDGKKRFIGIKMLTITP------------------