>Homo_sapiens_FGF18
--------------------------------------------------------------------------------
----------------------------------------------MYSAPSACTCLCLHFLLLCFQ-VQV---------
-------------------------------------------------------------------LVAEEN-VDFR--
--------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS-------
---------GKHIQVL------------GRRIS--ARGEDGDKYA------------------QLLVETDTFGSQVRIK-
-------GKETEFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN-----------
YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T
RENQQDVHFMKRYP-KGQP-------------------------------------------------------------
--------------------------------------------------------------------------------
-----ELQKPFKYTT---VTKRSRRIR---PTHPA---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Canis_familiaris_FGF18
--------------------------------------------------------------------------------
----------------------------------------------MYSAPSACTCLCLHFLLLCFQ-VQV---------
-------------------------------------------------------------------LAAEEN-VDFR--
--------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS-------
---------GKHIQVL------------GRRIS--ARGEDGDKYA------------------QLLVETDTFGSQVRIK-
-------GKETEFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN-----------
YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T
RENQQDVHFMKRYP-KGQA-------------------------------------------------------------
--------------------------------------------------------------------------------
-----ELQKPFKYTT---VTKRSRRIR---PTHPG---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Bos_taurus_FGF18
--------------------------------------------------------------------------------
----------------------------------------------MYSAPSACTCLCLHFLLLCFQ-VQV---------
-------------------------------------------------------------------LAAEEN-VDFR--
--------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS-------
---------GKHIQVL------------GRRIS--ARGEDGDKYA------------------QLLVETDTFGSQVRIK-
-------GKETEFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN-----------
YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T
RENQQDVHFMKRYP-KGQA-------------------------------------------------------------
--------------------------------------------------------------------------------
-----ELQKPFKYTT---VTKRSRRIR---PTHPG---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Gallus_gallus_FGF18
--------------------------------------------------------------------------------
-------------------------------------------VPYPPSRCSGLFCSWFLLCCFL---TVM---------
-------------------------------------------------------------------FVAEEN-VDFR--
--------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS-------
---------GKHIQVL------------GRRIS--AKGEDGDKYEA-----------------QLLVETDTFGSQVRIK-
-------GKETDFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN-----------
YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T
RENQQDVHFMKRYP-KGQV-------------------------------------------------------------
--------------------------------------------------------------------------------
-----EIQKPFKYTT---VTKRTKRIR---PTNPS---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Anolis_carolinensis_FGF18
--------------------------------------------------------------------------------
-----------------------------------------------------MLNLFLLPSLFLKK-TQM---------
-------------------------------------------------------------------FVAEEN-VDFR--
--------------------------------------IHVENQTRARDDVSRKQLRLYQL-------YSRTS-------
---------GKHIQVM------------GRRIS--AKGEDGDKY-A-----------------QLLVETDTFGSQVRIK-
-------GKETDFYLCMNRKGKLVGK---------------PDGTSKE----------CVFIEKVLENN-----------
YTALMSAKYS------------------------------GWYVGFTKKGRPR----KGPK------------------T
RENQQDVHFMKRYP-KGIV-------------------------------------------------------------
--------------------------------------------------------------------------------
-----DLQKPFKYTT---VTKRTRRIR---PTNPS---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Danio_rerio_FGF18_a
--------------------------------------------------------------------------------
-----------------------------------------------WKKMASISCRYIQMMLVMCNPLQ----------
-------------------------------------------------------------------VFGVDG-VNFS--
--------------------------------------VHVENQTRARDAMSRRQHRVYQL-------YSRTS-------
---------GKHVQVL------------GRKIS--ARGDDGDKY-A-----------------QLVVEADTFGSQVRIR-
-------GKETNFYLCMNRKGKLVGK---------------KASNRGAD---------CVFIEKVLENN-----------
YTALMSARYT------------------------------GWYVGFTKRGRPR----RGPH------------------T
LPNQQDVHFMKRFPPGEQP-------------------------------------------------------------
--------------------------------------------------------------------------------
-----DL-MPFRFTT---VSKRSKKVR---AARPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Danio_rerio_FGF18_b
--------------------------------------------------------------------------------
----------------------------------------------MRSVLWSAVVLCYQVVLLFYSPLQ----------
-------------------------------------------------------------------VLAVDN-VNFG--
--------------------------------------VHVENQTGVRDGLSRKHHRVYQI-------YSRTS-------
---------GKHVQVL------------GKKIT--AMGEDGDKY-A-----------------QLVVEADTFGSQVRIR-
-------GKETNYYLCMNRKGKLIGK---------------KDSSVNGG---------CVFIEIMLENN-----------
YTAWMSAHYV------------------------------GWYVGFTKKGRPR----RGPN------------------T
LPNQRDVHFMKRFPPGEQP-------------------------------------------------------------
--------------------------------------------------------------------------------
-----DL-QPCSFTT---VSKRSKRVQQPSASPPPLP-------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Takifugu_rubripes_FGF18_a
--------------------------------------------------------------------------------
----------------------------------------------MWSLLSTLTVLCIQMLLVMCNPLQQ---------
-------------------------------------------------------------------VLGVDG-VNFS--
--------------------------------------VHVENQTQVRDTMSRRHHRVYQL-------YSRTS-------
---------GKHVQVL------------GRKIS--ARGEDGDKYEA-----------------QLVVEADTFGSQVRIR-
-------GKETNFYLCMNNRGKLVGM---------------TANNRSED---------CVFVEKVLENN-----------
YTALMSARYA------------------------------DYYVGFTKKGRPR----RGRK------------------M
LPNERDVHFMKRFPPGEQP-------------------------------------------------------------
--------------------------------------------------------------------------------
-----NLTTPFRFTT---VSKRGKRVR---ATGPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Tetraodon_nigroviridis_FGF18_a
--------------------------------------------------------------------------------
----------------------------------------------SSGSHFFCFYRCIQMLLVMCNPLQ----------
-------------------------------------------------------------------VLGVDG-VNFS--
--------------------------------------VHVENQTQVRDTMSRRHHRVYQL-------YSRTS-------
---------GKHVQVL------------GRRIS--ARGEDGDKYEA-----------------QLVVEADTFGSQVRIR-
-------GKETNFYLCMNRRGKLVGK---------------KASNRSAD---------CVFVEKVLENN-----------
YTALMSARYT------------------------------DWYVGFTKRGRPR----RGPN------------------T
LPNQQDVHFMKRFPPGEQP-------------------------------------------------------------
--------------------------------------------------------------------------------
-----NLTTPFRFTT---VSKRGKRVR---ATGPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Gasterosteus_aculeatus_FGF18_a
--------------------------------------------------------------------------------
--------------------------------------------VLLSLLITFCICLRMPTSRCVCVLSQQ---------
-------------------------------------------------------------------VLSVDG-VNFS--
--------------------------------------VHVENQTQVRDTMSRRQHRVYQL-------YSRTS-------
---------GKHVQVL------------GRRIS--ARGEDGDKFEA-----------------QLVVEADTFGSQVRIR-
-------GKATDFYLCMNRRGKLVGK---------------KASNRSDD---------CVFVEKVLENH-----------
YTALMSARHA------------------------------GWYVGFTKRGRPR----RGPQ------------------T
LPNQQDVHFMKRFPPGEQP-------------------------------------------------------------
--------------------------------------------------------------------------------
-----DFTTPFRFTT---VSKRGKRVR---ATGPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Oryzias_latipes_FGF18_a
--------------------------------------------------------------------------------
----------------------------------------------MWSLLSTLTVLCIQMLLVMCNPLQ----------
-------------------------------------------------------------------VLGVDG-VNFS--
--------------------------------------VHVENQTQVRDTMSRRHHRVYQL-------YSRTS-------
---------GKHVQVL------------GRRIS--ARGEDGDKYEA-----------------QLVVEADTFGSQVRIR-
-------GKETNFYLCMNSRGKLVGK---------------KASNRSAD---------CVFVEKVLENH-----------
YTALMSARYT------------------------------DWYVGFNKRGRPR----PGSR------------------T
QPNQQDGHFMKRFPPGEQP-------------------------------------------------------------
--------------------------------------------------------------------------------
-----DLTTPFRFTT---ISKRGNRVR---ANGPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Ciona_intestinalis_FGF18
--------------------------------------------------------------------------------
---------------------------------------------MRPSI-CKDIYANLYRFLLGIIVLGDIAS------
-------------------------------------------------------------------GIPPNYIRD----
--------------------------------------YIKSEIFQENVSQSSSTRRYCEI-------YSKRT-------
---------SNHIRIL------------GKKVD--GRGRRGSNH------------------AKLIIHSKGLWGRIMIQ-
-------GVQTERFLCMNKRGRLVGKN-------------YRKAINDPK---------CLFFEEMLENY-----------
FDAFSNSKFR------------------------------DWHIGFHSNGRPK----RGPH------------------T
KEIGTDEMFIKKCTASSGMVPNPTAASNEKYKWIIGEFERDVKRHNKKKKRAPLS-------------------------
----------VLRPNYSVTRDSSTADEVMLADSSRTLSTLPPYVQAEIERRRSLYPVLRQQRRLDVTIPPAGGTVSAMDP
LYSSPKHRKLPRRNKPRRSRQNKKRKHRRHKSKWRSTVPTDIVDSDFQPTTGT---FTTPFPINSVSEPEAGFIRTP---
TTAPGLHRQRSRSGRRRPKQRRRTKKVHGRKQKTGRRNRKRANT------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Homo_sapiens_FGF17
--------------------------------------------------------------------------------
---------------------------------------------MGAARLLPNLTLCLQLLILCC-QTQ----------
--------------------------------------------------------------------GENHPSPNFN--
--------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS-------
---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK-
-------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN-----------
YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S
RQNQREAHFIKRLYQGQLPFPN----------------------------------------------------------
--------------------------------------------------------------------------------
---HAEKQKQFEFVG-SAPTRRTKRTRRPQPLT-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Mus_musculus_FGF17
--------------------------------------------------------------------------------
---------------------------------------------MGAARLLPNLTLCLQLLILCC-QTQ----------
--------------------------------------------------------------------GENHPSPNFN--
--------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS-------
---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK-
-------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN-----------
YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S
RQNQREAHFIKRLYQGQLPFPN----------------------------------------------------------
--------------------------------------------------------------------------------
---HAERQKQFEFVG-SAPTRRTKRTRRPQSQT-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Canis_familiaris_FGF17
--------------------------------------------------------------------------------
---------------------------------------------MGATCLLPNLTLCLQLLILCC-QTQVTAK------
--------------------------------------------------------------------GENHPSPNFN--
--------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS-------
---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK-
-------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN-----------
YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S
RQNQREAHFIKRLYQGQLPFPN----------------------------------------------------------
--------------------------------------------------------------------------------
---HAERQKQFEFVG-SAPTRRTKRTRRPQPLT-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Bos_taurus_FGF17
--------------------------------------------------------------------------------
---------------------------------------------MGAARLLPNLTLCLQLLILCC-QTQG---------
----------------------------------------------------------------------NEVKPRER--
--------------------------------------EHERDRCAPCRRVSRQEVVCFSP-------IQRCR-------
---------WTQIQKS------------GPLLHPWAGSPNGRRFLPLPT-------------AKLIVETDTFGSRVRIK-
-------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN-----------
YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S
RQNQREAHFIKRLYQGQLPFPN----------------------------------------------------------
--------------------------------------------------------------------------------
---HAERQKQFEFVG-SAPTRRTKRTRRPQPLT-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Loxodonta_africana_FGF17
--------------------------------------------------------------------------------
---------------------------------------------MEAARLLPNLTLCLQLLILCC-QTQVTAK------
--------------------------------------------------------------------GENHPSPNFN--
--------------------------------------QYVRDQGAMTDQLSRRQIREYQL-------YSRTS-------
---------GKHVQVT------------GRRIS--ATAEDGNKF------------------AKLIVETDTFGSRVRIK-
-------GAESEKYICMNKRGKLIGK---------------PSGKSKD----------CVFTEIVLENN-----------
YTAFQNARHE------------------------------GWFMAFTRQGRPR----QASR------------------S
RQNQREAHFIKRLYQGQLPFPN----------------------------------------------------------
--------------------------------------------------------------------------------
---HAERQKQFEFVG-SAPTRRTKRTRRPQPIT-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Danio_rerio_FGF17_a
--------------------------------------------------------------------------------
----------------------------------------------MYGINQRYLYISFHFFVVWC-HAQG---------
--------------------------------------------------------------------EKNHPSPNFK--
--------------------------------------QYVREQGSLTDQLSRRQVRVYQL-------YSRTS-------
---------GKHVQIR------------GHRVS--ATADDGNSY------------------ARLYVETDTFGSRVRIK-
-------GAESGRYLCMNRRGKLVGK---------------PNGRGRD----------CIFTEIVLENN-----------
YTALENARHE------------------------------GWFVAFTRKGRPI----RASK------------------T
RQNQREVHFIKRLHKGPQPFP-----------------------------------------------------------
--------------------------------------------------------------------------------
---NAEQPKHFEFIS-FPSTRRAKRNRKHQTAS-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Takifugu_rubripes_FGF17_a
--------------------------------------------------------------------------------
---------------------------------------------VALSNPIPLFCRSIHFFVLWC-HAQKK--------
--------------------------------------------------------------------GENHPSPNFK--
--------------------------------------QYVRTQGEVSDQLSRRQVRVYQL-------YSRTS-------
---------GKHVQIQ------------GKRVT--ATAEDGNIY------------------ARLLVETDSFGSRVRIR-
-------GAESGHYLCMNRRGKLVGK---------------PNGRSRE----------CIFSEIVLENN-----------
YTALQNAKYE------------------------------GWYVAFSRKGRPI----KASR------------------T
RQNQREVHFIKRLHAGPPPFP-----------------------------------------------------------
--------------------------------------------------------------------------------
---NMDQSKHFEFFR-FSATSRAKRNRKSGTVS-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Tetraodon_nigroviridis_FGF17_a
--------------------------------------------------------------------------------
----------------------------------------------MQGITQRCVYISLHFLALWC-QAQ----------
--------------------------------------------------------------------GENHPSPNFK--
--------------------------------------QHVRTQGAASDPLSRRQVRVYQL-------YSRTS-------
---------GQHVQIQ------------GRRVT--ATAADGSPH------------------ARLFVETDSFGSRVRIR-
-------GAESGRYLCMNRKGKLVAK---------------PNGESRE----------CIFSEIVLENN-----------
YTAFQNAKYE------------------------------GWYVAFSRKGRPI----KASR------------------T
RENQREVHFIKRLHAGPPPFP-----------------------------------------------------------
--------------------------------------------------------------------------------
---NVDQSQHFEFIR-LSGTRRAKRNRKTRTFS-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Gasterosteus_aculeatus_FGF17_a
--------------------------------------------------------------------------------
----------------------------------------------MYGINQRCIYISFHLFVLWC-HAQKK--------
--------------------------------------------------------------------GENHPSPHFK--
--------------------------------------QYVRTQGAGTDQLSRRQVRVYQL-------YSRTS-------
---------GKHVQIH------------GRRVT--ATAEDGDVF------------------ARLFVETDTFGSRVRIR-
-------GAESRRYLCINRKGKLVGK---------------PNGRSRD----------CIFTEIVLENN-----------
YTAFQNAKYE------------------------------GWYVAFTRKGRPV----KASR------------------T
RENQREVHFIKRLHTGPPSFP-----------------------------------------------------------
--------------------------------------------------------------------------------
---NTDQSKQFEFIR-FPAASRAKRNRKSRTFS-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Drosophila_melanogaster_FGF17
---------------------MRRNLRLDWRALALLGALLSFIIAWRGLVSAMPLMAMDNNLTDSSGSTNTSTSSTSKYN
STNNSNLFSNSYLQSDHSRSSLVPSAVSERSVNQPTNQSINAEFNQSLSTHPTAITSTPQTQTQTQIQSQYPSQAE----
-------------------------------------------DSDQLEEPLGFVISAMPNEHLAVLSRTERSIRHQNQQ
QQKKHHHHHQQQQQQQHQQQQPMSPADNNFIGSKSKRLSNPRSSLNINSSSSNTPISNLDR-------NERSTVP-----
QSHLAW--TSRKIQLYIK----------NRILQILRDGVVNGTQDENSE-------------FTILQRSTVDVGRIKLQ-
-------SVATCLYLCMDACGVPYGS----------------KDFTDD----------CVFNENMGLQN-----------
YNTYSSTYHSQAR----------------------R----VFYLALNGSGQPR----RTQIPASRSLGKLSTYTNAITET
VPQERVEQLIAKNFGANRVKHGVRQLCDTGKPLIELIDVARFKAPPHCSSN-----------------------------
--------------------TSGSSSSISSSSSSSSKSSSNSSSSYVPVSAISSLSSISNSSQSESGHISSSLSGSSNSN
SSSNSSSSNSSSNSSRPSGSKANKKKKPKCKPHEQEDTHNCQKRGGAGAGALRKLGPKAKRCKELREKAAAEKRAPPNCG
KKNGARKNPTEAAKAVQQRPKGNIQHGGKKKPNKAGKQRQNGGKKQQQQQQHQLQQQPLQHQAKSISGGKRKHRKLDAST
TTTMATSLGTPPSSHWESSSPLPAFSLSETSDRVERNVRMSSGEEQDQDNDQDQEQSDPGEQGEEETEGDGGSLEDASYE
DSSSEAQGRSGAGGDDSLYYDFLCLQLIAMVLLRKRAIL-----------------------------------------
------------------------------------------------
>Anopheles_gambiae_FGF17
----------------------MLSGRIRRRALALLGALLLVILVWPPCCATMPKPLSVTSPQAPWDVVPPARPHPAAAV
MPVPVQPSWTSGEGTFAPKRHHVPIGPGSERHQNEQHQQQQQEPAESESRKSRRVSEFYRLLRALSPATQPRPTFEPNER
TQSEVSAAVQLNLPPRENSRAGRVAR------DYLIEPIDKNKSQSARPASALDLPQDNAPVRVHARFDDTNRSPALSRS
RREALPANPHRHQHQLAPAGAPMNGTGVWHGRRGGGGHRHHHQHHQQQQQQNRNIESNLER-------NERSAN------
LSHITG--ATRKIQLFIK----------NRYIQLLPDGTVNGTSDDLSD-------------YTILQRTTVGIGQIKIQ-
-------AVATCLFLCMDTCGSVYGS----------------KEFTDD----------CIFNEQMEQHH-----------
YNTYSSTQHSNAR----------------------R----TLYLALNKTGQPR----KIQIPVNRTLGKLATYTKALTLT
VAHDRVEQLISRLFGADHVRHGLNHLCETGQPLVELTAKEMRPRPVCGAQAGPMKGIAAATSTGGGGGGGGKKNGQQNTA
GKDEKEGLRQKKKKKRRKCREDEVPGEHCFRPGASGAGVGGTNSGKKKAGPNQGQSRGNSSISSDSGSISPSGSNSSVGS
SSAGTNQSASLNNVTGSSSSSSSSSSSSSSSISNSSSANSLIASISNGGPVRPGQPSAQLTATPNARKPKPTKKLPGGPR
NGTQPPSGGNTGTTGGGPSRKPKKPNQQSQNQQQQMANGKRNGTGGNSAKPSPAKIKLVGASIVTSKLSHPKPASLMIAR
TVRPTTPFPLVTARPTSGPTTVSNDLLDTSQQSDDSELDMDDALQASAELVDELDDLDEGMLTVPGHAINFVDEEDLDDM
EF------------------------------------------------------------------------------
------------------------------------------------
>Homo_sapiens_FGF8
--------------------------------------------------------------------------------
-----------------------------------------------MGSPRSALSCLLLHLLVLCLQAQEGPG------
----------------------------------------RGPALGRELASLFRAGREPQGVS---QQVTVQSSPNFT--
--------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS-------
---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR-
-------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN-----------
YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPRGHHT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Mus_musculus_FGF8
--------------------------------------------------------------------------------
-----------------------------------------------MGSPRSALSCLLLHLLVLCLQAQVRSA------
----------------------------------------AQKRGPGAGNPADTLGQGHEDRP---FGQRSRAGKNFTNP
APNYPEEGSKEQRDSVLPK----------------VTQRHVREQSLVTDQLSRRLIRTYQL-------YSRTS-------
---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR-
-------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN-----------
YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPRGHHT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Canis_familiaris_FGF8
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------LG---APGQSSIIMACCVFFNFLKVTVQSSPNFT--
--------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS-------
---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR-
-------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN-----------
YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPRGHHT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Bos_taurus_FGF8
--------------------------------------------------------------------------------
-----------------------------------------------MGSPRSALSCLLLHLLVLCLQAQEGPG------
----------------------------------------GGPALGRELASLFRAGRESQGVS---QQVTVQSSPNFT--
--------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS-------
---------GKHVQVL------------ANKR-INAMAEDGDPF------------------AKLIVETDTFGSRVRVR-
-------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN-----------
YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPRGHHT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Loxodonta_africana_FGF8
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------PI------------------AKLIVETDTFGSRVRVR-
-------GAETGLYICMNKKGKLIAK---------------SNGKGKD----------CVFTEIVLENN-----------
YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPRGHHT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEQSLRFEFLNYPPFTRSLRGSQRTWAPEPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Gallus_gallus_FGF8
--------------------------------------------------------------------------------
----------------------------------------------------------FMHLFVLCLQAQ----------
--------------------------------------------------------------------VTVQSPPNFT--
--------------------------------------QHVREQSLVTDQLSRRLVRTYQL-------YSRTS-------
---------GKHVQIL------------DNKK-INAMAEDGDVH------------------AKLIVETDTFGSRVRIK-
-------GAATGFYICMNKKGKLIGK---------------SNGKGKD----------CVFTEIVLENN-----------
YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPKGHQT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEPHRRFEFLNYP-FNR-RSKRTRNSSARVRP--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Anolis_carolinensis_FGF8
--------------------------------------------------------------------------------
-----------------------------------------------MNFFSSIFSYLVLHLFAFCLQAQ----------
--------------------------------------------------------------------VTVQSPPNFT--
--------------------------------------QHVREQSLVTDQLSRRLVRTYQL-------YSRTS-------
---------GKHVQIL------------DNKK-INAMAEDGDAH------------------AKLIVETDTFGSRVRIK-
-------GAETGFYICMNKKGKLIGK---------------SNGKGKD----------CVFTEIVLENN-----------
YTALQNAKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPKGHQT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEPHRRFEFLNYP-FNR-RSKRTRNSSPKPSP--------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Xenopus_tropicalis_FGF8
--------------------------------------------------------------------------------
-----------------------------------------------MSYITSILGYLLLHLFVICLQAQARAG------
---------------------------------------RIG----SPTEREGIRRESEAPRGEVSTQVTVQSPPNFT--
--------------------------------------QHVREQSLVTDQLSRRLIRTYQL-------YSRTS-------
---------GKHVQIL------------GNKK-INAMAEDGDPH------------------AKLIVETDTFGSRVRIK-
-------GAETGYYICMNKKGKLIGK---------------TSGRGKD----------CVFSEIVLENN-----------
YTALQNVKYE------------------------------GWYMAFTRRGRPR----KGSK------------------T
RQHQREVHFMKRLPKGHHT-------------------------------------------------------------
--------------------------------------------------------------------------------
----TEPHKRFEFINYP-FNR-RSKRTRYSSSR-----------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Danio_rerio_FGF8_a
--------------------------------------------------------------------------------
-----------------------------------------------MRLIPSRLSYLFLHLFAFCYY------------
------------------------------------------------------------------AQVTIQSPPNFT--
--------------------------------------QHVSEQSKVTDRVSRRLIRTYQL-------YSRTS-------
---------GKHVQVL------------ANKK-INAMAEDGDVH------------------AKLIVETDTFGSRVRIK-
-------GAETGFYICMNRRGKLIGK---------------KNGLGKD----------CIFTEIVLENN-----------
YTALQNVKYE------------------------------GWYMAFTRKGRPR----KGSK------------------T
RQHQREVHFMKRLPKGHQ--------------------------------------------------------------
--------------------------------------------------------------------------------
----IAEHRPFDFINYPFNRRTKRTRYSGER-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Takifugu_rubripes_FGF8_a
--------------------------------------------------------------------------------
-----------------------------------------------MRPIPSRLSYLFLHLFAFCYYAQEAFD------
------------------------------------------PTWREFSMELAAIFIRDHTPQSIVAQVTNQSPPNFT--
--------------------------------------QHVSEQSKVTDHVSRRLIRVYQL-------YSRTS-------
---------GKHVQVL------------PNKK-INAMADDGDVH------------------AKLIVETDTFGSRVRIK-
-------GAETGFYICMNKRGKLVGK---------------KNGQGRD----------CIFTEIVLENN-----------
YTALRNARYE------------------------------GWYMAFTRRGRPR----KGSR------------------T
RQHQREVHFMKRLPKGQQPVH-----------------------------------------------------------
--------------------------------------------------------------------------------
----PSHHRPFDFIHYPFNQRTKRTRHSSERPNPR---------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Tetraodon_nigroviridis_FGF8_a
--------------------------------------------------------------------------------
-----------------------------------------------MQTISSRLSYLFLHLFAFCYY------------
------------------------------------------------------------------AQVTNQSSPNFT--
--------------------------------------QHVSEQSKVTDHVSRR-IRIYQL-------YSRTS-------
---------GKHVQVL------------PNKK-INAMADDGDVHV-----------------AKLIVETDTFGSRVRIK-
-------GAETGFYICMNKRGKLIGK---------------KNGQGRD----------CIFTEIVLENN-----------
YTALRNARYE------------------------------GWYMAFTRRGRPR----KGSR------------------T
RQHQREVHFMKRLPKGQQPVH-----------------------------------------------------------
--------------------------------------------------------------------------------
----PSHHRPFDFIHYPFNQRTKRTRYSSES-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Gasterosteus_aculeatus_FGF8_a
--------------------------------------------------------------------------------
---------------------------------------------RAICFMLPRLN-KCLHLFSFCYF------------
------------------------------------------------------------------AQVTNQSPPNFT--
--------------------------------------QHVSEQSKVTDRVSRRLIRVYQL-------YSRTS-------
---------GKHVQVL------------PNKK-INAMADDGDVH------------------AKLIVETDTFGSRVRIK-
-------GAETGFYICMNKKGKLIGK---------------NNGHGRD----------CIFTEIVLENN-----------
YTALRNARYE------------------------------SWYMAFTRRGRPR----KGSR------------------T
RQHQREVHFMKRLPKGQQPAH-----------------------------------------------------------
--------------------------------------------------------------------------------
----TSHHRPFDFVHYPFRQRTKRTRYSSER-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Oryzias_latipes_FGF8_a
--------------------------------------------------------------------------------
----------------------------------------------FTSLIPPVIGHGFLHLFAFCHY------------
------------------------------------------------------------------AQVTNQSSPNFT--
--------------------------------------QHVSEQSRVTDHVSRRLIRVYQL-------YSRTS-------
---------GKHVQVL------------SNKK-INAMAEDGDVH------------------AKLIVETDTFGSQVRIK-
-------GAQTGLYICMNKKGKLIGK---------------KNGQSRD----------CIFTEIVLENN-----------
YTALRNAHYN------------------------------DWYMAFTRRGRPR----RGSQ------------------T
RQHQREVHFMKRLPRGQQVIH-----------------------------------------------------------
--------------------------------------------------------------------------------
----SSQHRPFDFIHS-FSQRTKRTRYSSER-------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------------------------------------
>Ciona_savignyi_FGF8
--------------------------------------------------------------------------------
---------------------------------------------MRPKITCENLYATICRFLLCVIIFGDETN------
-------------------------------------------------------------------AISNKRIED----
--------------------------------------YITMALSRS--QTTASTRRYYEI-------YAKAT-------
---------SSRVQIL------------GKRVN--AKGVRGNKY------------------SKMAILSTSFGGRIMIQ-
-------GVETGRVLCMNRKGRLVGKV-------------LRRAKHDLK---------CQFNDLMMPNL-----------
FDYFTNVAHP------------------------------KWYVAFNSHGRPK----KGPT------------------T
KLGQVETMFLKRPIETFGYPSGAPVTDDSRFGEIARAMIKQIRGHPRRKHSR----------------------------
----------AFTGSNRLMRDSPSAGEVMFPDAN--SPSLPPDVEAEMARRRSVLSDVQRQLSLDVTIPAHAPTVSATGP
PDWSTRVQVRYRGQRKRNKRKRKNKKLRKVRKKPMPTVPTNVMDTDFDIQATTRPHLPTARPFAGLVRNVSGLPTFPSAV
RTTESRHAGRRHGTKKRNKKRKSSLRKRGRRRRTRMRNRNSVNT------------------------------------
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