>Homo sapiens_PDE1B
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD

>Mus musculus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK
FRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCLKNLDLWCFDVFSLNRAADDHALR
TIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLR
TGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVF
RMMQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKA
LSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQ
IGFIDFIVEPTFSVLTDVAEKSVQPLADDDSKPKSQPSFQWRQPSLDVDVGDPNPDVVSF
RATWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD

>Rattus norvegicus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK
FRSIVHAVQAGIFVERMFRRTYTAVGPTYSTAVHNCLKNLDVWCFDVFSLNRAADDHALR
TIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLR
TGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVF
RMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKA
LSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQ
IGFIDFIVEPTFSVLTDVAEKSVQPLTDDDSKSKSQPSFQWRQPSLDVDVGDPNPDVVSF
RSTWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD

>Bos taurus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGPSEEKPKF
RSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNVDLWCFDVFSLNRAADDHALRT
IVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRT
GMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFR
MMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKSMKTALQQLERIDKSKAL
SLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQI
GFIDFIVEPTFSVLTDVAEKSVQPTGDDDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFR
STWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPASPAEDEHNQNGNLD


>Equus caballus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLESGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPK
FRSIVHAVQAGIFVERMFRRTYTSVGPTYSAAVLNCLKNLDLWCFDVFSLNRAADDHALR
TIVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLR
TGMVHCLSEIEILAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVF
RMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKSMKTALQQLERIDKSKA
LSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQ
IGFIDFIVEPTFSVLTDVAEKSVQPQADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSF
RSTWTKYIQENKQKWKERAASGITNQMSIDELCPCEEEAPSSPAEDEHNQNGNLD

>Xenopus tropicalis_PDE1B
MESPSVDKDLLEGCTSPFELKSAPSKKMWVKLRSLLKYMVKQLENGEVNIVELKKNLEYT
ASLLEAVYIDETRQILDTDDELPEMRSDSVPSEVRDWLASTFTQQTRSTGRRSEEKPRFR
SIVHAVQAGIFVERMFRRSYTAVGPNYSAAVVNSLKHLDLWDFDVFVLNRVSEDHALKTI
VFELLSRHNLNSRFKIPVAFLMSFLDSLESGYGKYKNPYHNQIHAADVTQTVHCFLLRTG
MVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSDCAILYNDRSVLENHHVSAVYRI
MQDDEMNIFVNLTKDEFTELRSLVIEMVLATDMSCHFQQVKTMKTSLQQLETIDKSKALS
LLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGLPFSPLCDRKSTLVAQSQIG
FIEFIVDPTFSVLTDVAEKTVLPLVEERSKSKSTASVNQSSSQWRQPSIDDHSEMGDINA
DIKSFRTTWTKYIQENKQKWKERAASGITNQTSVDELSPCEEQHSTEENGNLD

>Takifugu rubripes_PDE1B
MAELLRIRKKRLQIPISRLRSILKQLEEKNVDFEEIKKNLDFTASLLEAVYLDGTRQCLE
TEDDLQQLQSDGVPAEVTDWLASTFTRRVRQPARRSDEKPKFRSIVHAVQAGIFVERMFK
RAYTAALPDQPAAVVNCLRDVDRWSFDVFALNSASSDRALQTVFFELIARYGLNGRFKIP
ISCLTEFLSAVERGYCKHNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAA
AIHDYEHTGTTNNFHIHTKSEFALIYNDRSVQESHHLSAAFRLLQNEQMNIFVNLTREEW
MELRSLVIEMVLSTDMSSHLSQVKAIKACLQQQERIDKPKALSLLLHTADISHPSKPWPL
HSRWTKALMEEFFRQGDREAELGLPFSPLCDRNSTLVAESQIGFIDFIVYPTFSLLTDMA
EKIVIPLVEENPGPPDPCNRHSNLWRESSRGLQWSLAHITAELVSFRSTWTRHTEDNKFK
WKESGCNG

>Tetraodon nigroviridis_PDE1B
MAEMLRIRKKRLQIPISRLRSILKQLEEKNVDYEEIKKNLDFTASLLETIYFDGTRQCLE
TEDDLQQLQSDGVPAEVTDWLASTFTRRVRRPVRRSDEKPKFRSIVHAVQAGIFVERMFK
RAYTAALPDQPTAVVNCLRDVDRWSFDVFALNSASSDRALQIVFFELIARYGLNGRFKIP
ISCLTEFLSAVERGYCKYNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAA
AIHDYEHTGTTNNFHIHTMSEFALIYNDRSVQESHHLSAAFRLLQNEQMNIFINLTREEW
MELRSLVVEMVLSTDMSSHLLQVKAMKACLQQQERIDKPKALSLLLHTADISHPSKPWPL
HSRWTKALMEEFFQQGDREAELGLPFSPLCDRKSTLVAESQIGFIDFIVYPTFSLLTDMA
EKVVIPLVEENPGPPDPCNRHSNLWRESSRGLQWSLAHITAELVSFRSTWTRHTEDNKFK
WKESGSNGMS>Homo sapiens_PDE1A
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKH
DETHS

>Mus musculus_PDE1A
MGSTDTDIEELENATYKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKPEEKPKFRS
IVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKSQSSNYGASSSSTMIGFHVADSLRRSNTKGS
VCDGSYAPDYSLSAVDLKSFKNNLVDIIQQNKERWKELAAQGELDLHKNSEELGNTEEKH
ADTRP

>Rattus norvegicus_PDE1A
MGSTDTDIEELENATYKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
IVHAVQAGIFVERMYRKNYHMVGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMI
YELFTSNDLINRFKIPVSCLIAFAEALEVGYSKHKNPYHNLVHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAVHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILVNLSKDDWRDLRNLVIETVLATDMSGHFQQIKNIRSSLQQPEGIDRAKTMSL
ILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKPESSNYGASSSSTMIGFHVADALRRSNTKGC
MSDGTYAPDYSLSAVDLKSFKNNLVDIIQQNKERWKELAAQGELDLHKNSEDLEEKHADT
HP

>Bos taurus_PDE1A
MDDHVTIRRKHLQRPIFRLRCLVKQLEKGDVNVIDLKKNIEYAASVLEAVYIDETRRLLD
TDDELSDIQSDSVPSEVRDWLASTFTRKMGMMKKKSEEKPRFRSIVHVVQAGIFVERMYR
KSYHMVGLAYPEAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIP
VSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAA
AIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNVLINLSKDDW
RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGLDKAKTMSLILHAADISHPAKSWKL
HHRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDST
EKIIIPLIEEDSKTKTPSYGASRRSNMKGTTNDGTYSPDYSLASVDLKSFKNSLVDIIQQ
NKERWKELAAQGEPDPHKNSDLVNAEEKHAETHS

>Canis familiaris_PDE1A
MDDHVTIRKKHLQRPIFRLRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLD
TEDELSDIQTDSVPSEVRDWLASTFTRKMGMMKKKSEEKPKFRSIVHAVQAGIFVERMYR
KSYHMVGLVYPEAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIP
VSCLISFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAA
AIHDYEHTGTTNNFHIQTRSDVALLYNDRSVLENHHVSAAYRLMQEEEMNVLINLSKDDW
RDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDKAKTMSLILHAADISHPAKSWQL
HYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDST
EKIIIPLIEEASKTDTSSYGASRRSNMKGTMNDGTYSPDYSLASVDLKSFKNNLVDIIQQ
NKERWKELAAQGEPDLHKNSEDLVNAEEKHVDTHS

>Equus caballus_PDE1A
MGSTAADTEELENTTFKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNIVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMKKKKSEEKPKFRS
IVHAVQAGIFVERMYRKSYHVVGLAYPEAVIVTLKDVDKWSFDVFALNEASGEHSLKFII
YELFTRYDLINRFKIPVSCLIAFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNVLINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKSWQLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIIIPLIEEDSKTENPSYGASRFGTFMGXHVADLFRRSNIKGT
MNDGTYSPDYSLACVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLANAEEKH
ADIHS

>Ornithorhynchus anatinus_PDE1A
MGSTATELEEYGSTSLKYLIGEQTEKMWQRLKGILRCLVKQLEKGDVNVVDLKKNIEYAA
SVLEAVYIDETRKLLDTEDELSDIQSDSVPLEVRDWLASTFTRKMGMAKKKTEEKPKFRS
IVHAVQAGIFVERMYRRTSNMAGLAYPAAVIVTLKDVDKWSFNVFALNDASGEHSLKFMM
YELFTRYDLISRFKIPVSCLISFAEALEVGYSKFKNPYHNLIHAADVTQTVHYILLHTGL
MHWLSELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEDMNILTNLSKDDWRELRGLVVEMVLSTDMSGHFHQIKTMRNTLQQPEGVDKGKAMSL
ILHAADISHPAKSWDLHHKWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTERIVVPLIEESCRSESSCLPCSPSPTSQNSDGGLTATDTQKKPS
GKLTSNEGPSSSNYSLASVDLKSFKNNLVDIIQQNKERWKELALQERVLRSDRKLKKKHR
PAPGAKLEDKGSSSDSKDIKESSGGQSLMGASAPDPAANPSGSRPQLWLKSGPIPRPDGD
DGDIEIERHFLSSSQVEEVFM

>Taeniopygia guttata_PDE1A
MTQDQQDTCALLEQQLATRLRCLVKQLEKGDINVVDLKKNIEYAASVLEAVYIDETRKLL
DTEDELSDIQSDSVPLEVRDWLASTFTREMGIVKRRPEEKPKFRSIVHAVQAGIFVERMY
RKTSSMVGLAYPAEVIVTFKDVDKWSFDVFALNEASGEHSLKFMMYELLTRYDLLSRFKI
PVPNLISFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMIHTGIMHWLTELEILAMIFA
AAVHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILANLNKDD
WRELRSLVIEMVLSTDMSGHFQQIKTMRHTLQQAQGVDKAKAMSLILHAADISHPAKSWE
LHYRWTMALMEEFFRQGDKEAALGLQFSPLCDRKSTLVAQSQIGFIDFIVEPTFSLLTDS
MEKIVMPLIEEATKSESPAFGTPSQNSLGAVSNAEAQRRPGFKSTGDGGTHTENSLATVD
LRGFKDNLMKIIQANKERWKELAAEGEPKHCKSEDIVKATEQTEALVQN

>Gallus gallus_PDE1A
MTQDLQDTCALLEQQLGTRLRCLVKQLEKGDINVVDLKKNIEYAASVLEAVYIDETRRLL
DTEDELSDIQSDSVPLEVRDWLASTFTREMGIVKRRPEEKPKFRSIVHAVQAGIFVERMY
RRTSSMVGLAYPAEVIVTFKDVDKWSFDVFALNEASGEHSLKFMMYELFTRYDLLNRFKI
PVPNLITFAETLEVGYSKYKNPYHNLIHAADVTQTVHYILIHTGIMHWLTELEILAMIFA
AAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILANLTKDD
WRELRSLVIEMVLSTDMSGHFQQIKTMRHTLQQAEGVDKAKAMSLILHAADISHPAKSWE
LHYRWTMALMEEFFRQGDKEAALGLQFSPLCDRKSTLVAQSQIGFIDFIVEPTFSLLTDS
MEKIVMPLIEEASKSESPAFGTPGQNNLGAVSNVDAQRRHNFRSTASDGAAHTENSLATV
DLRSFRDNLMQIIQANKERWKELAVEVRYKLLMVSVTVGSGGKGISLEIPVYLMPSEEEL
VKNVDEQEKDQSRNSTDAQLQEETRSRQNESSQGSGGTACPPRPIVLQVVTSNTSLSDES
NSEKCTNSDPNQKDLTDAQQETQNTDPLNDTSVKLLYTAVC

>Anole lizard_PDE1A
MGSTGTERNEGMDSALLKYPIRGHTEKMWQRLKGILRCLVKQLEKGDVNIIDLKKNIEYA
ASVLEAVYIDETRKLLDTDDELSDMRTDSVPMEVRDWLASTFTRKMGMTKRRPEEKPKFR
SIVHAVQAGIFVERMYRRTSSMVGLAYPSEVITTFKDVDKWSFDVFALNEASGGHSLKFM
MYELLIRYDLVSRFKIPVPSLISFAETLENGYSKHRNPYHNLIHAADVTHTVHCILLLTG
IMHWLTELEILAMIFAAAIHDYEHTGTTNNFHIQTRSDVAMLYNDRSVLENHHVSAAYKI
MQEDEMNILLNLSKDEWRELRTLVIEMVLSTDMSGHFQQIKTIRHTLQETEGIDKAKAMS
LILHAADISHPSKTWNLHFRWTKALMEEFFQQGDKEAELGLPFSPLCDRKSTMVAQSQIG
FIDFIVKPTFALLTDSMEKIVLPLIVEASKSETSTITSRKTVNMGGLHFKQKYHHLEVQK
KLTIKTSTCSGLSAVDLNRFKEDLFQIVQENKDRWKDLAEKG

>Xenopus tropicalis_PDE1A
MESTAFESEDPEYPSSNFETRESNDKMVQRLQGILRCLVKQLEKGDINVTDLKNNIEYAA
SVLEAVYIDETRRLLDTEDELSDIHTDSVPLEVRDWLASTFTRKMGMRKRRPEEKPKFRS
IVHAVQAGIFVERMYRRSSNIAGLTYPSSVIASMKDVDRWAFNVFTLNEASGEHALKFMV
YELFTRYDLTNRFKIPVSNLVSFVEALEVGYSKYKNPYHNLVHAADVTQTVHYIILHTGI
MHWLTELEILAMIFAAAIHDFEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRIM
QDDEMNIFINLSKDDWRDLRTLVIEMVLSTDMSGHFQQLKTMRSTLQQPEGIDKAKAMSL
ILHAADISHPAKPWDMHLRWTNLLMEEFFRQGDKEAALGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFTLLTDSTEKIVFPLIEEAAKSDNSVFDKSSQNNSEVVRGTDTPRKPSVRTS
QMDGSSPSEYSLATVDLHHFKKNLVEIIQQNKERWKELAAQERNLKSTHKSEGGTGGT

>Danio rerio_PDE1A
MDEDVTIKRKLLHRPIFRLRCLVKQLDKGEVNVVDLRKNIEYAASVLEAVYIDETRRLLD
TEDELSDIQADSVPMEVRDWLASTFTRKMGVVRRRPEEKPRFRSIVHAVQAGIFVERMYR
RTSNMAGLTYPPSVITALKDVDKWSFDVFKLQEASSDHALKFLVYELLTRYDLISRFRIP
VSSLVSFVEALEIGYSKHRNPYHNLIHAADVTQTAHYLMLHTGVMHWLTELEILAMVFAA
AIHDFEHTGTTNNFHIQTRSEVAILYNDRSVLENHHVSAAYRLMQEDEMNILVNLSKDDW
RELRTLVIEMVMSTDMSCHFQQIKTMRNSLQQPEGIDKAKALSLMLHAADISHPAKGWKL
HYRWTQALMEEFFRQGDKEAELGLPFSPLCDRKATMIAQSQIGFIDFIVEPTFSVLVDTT
EKIISPLIEEAVKSGGVRRSSLTGRGSAAVVESVQRHSDRGSNDECGGSTDYSLCGIDQK
HVRHLLSEIIQNNKERWKELSVQGLTQISLSLHTASQKTGHSQLANKQHERMSDLQEEPM
RSTQLTLSQENHDSESKSLNELNNTDSTHSSQDSLDQSSQSPTEGAGDASPEEHSSETLP
WNGKSA

>Oryzias latipes_PDE1A
LYSSHQLIIIICTQVFKYIHLQKRRKIMTGILMLKAALEQMDRGVVDLQELRRNLELAAA
MLDAVYTDETRRLLDTEDELSDLQAESVPSEVRDWLACTFSRRTGLSKRRPEEKPRFRSI
VHAVQAGIFVERMYRRTSNMAGLTYPPTALNALKEVDQWSFDVFTFHDATGEHALKFIVY
DLLTRYDLINRFRIPVQALVQFVEALESGYSKHRNPYHNLIHAADVTQTAHFLMLHTGLM
HWLSELEILAMVFAAAIHDFEHTGTTNNFHIHTRSEVAILYNDRSVLENHHVSAAYKLMA
EEDMNILVNLNKDDWRELRSLVIEMVMSTDMSCHFQQIKTMRNSLTQTDSIDKVKVLSLM
LHAADISHPAKAWPLHYHWTHSLMEEFFRQGDKEVELGLPFSPLCDRKATMIAQSQIGFI
DFIVEPTFSVLIDTTDKVIGPLIEEDRKARETGNRRPSLTGSGSVTVESVQRHSSGLHGN
SDDGPTDFSLTAIDLPALRLHLSSVIVSNKERWKELSVHGKYTVHKSSLSLLQQAQISKA
THH

>Homo sapiens_PDE1B
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD

>Mus musculus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK
FRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVHNCLKNLDLWCFDVFSLNRAADDHALR
TIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLR
TGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVF
RMMQDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKA
LSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQ
IGFIDFIVEPTFSVLTDVAEKSVQPLADDDSKPKSQPSFQWRQPSLDVDVGDPNPDVVSF
RATWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD

>Rattus norvegicus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELRELRSDAVPSEVRDWLASTFTQQTRAKGRRAEEKPK
FRSIVHAVQAGIFVERMFRRTYTAVGPTYSTAVHNCLKNLDVWCFDVFSLNRAADDHALR
TIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKNPYHNQIHAADVTQTVHCFLLR
TGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVF
RMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKSKA
LSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQ
IGFIDFIVEPTFSVLTDVAEKSVQPLTDDDSKSKSQPSFQWRQPSLDVDVGDPNPDVVSF
RSTWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPSSPAEDEHNQNGNLD

>Bos taurus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQTRAKGPSEEKPKF
RSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNVDLWCFDVFSLNRAADDHALRT
IVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRT
GMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFR
MMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKSMKTALQQLERIDKSKAL
SLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQI
GFIDFIVEPTFSVLTDVAEKSVQPTGDDDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFR
STWTKYIQENKQKWKERAASGITNQMSIDELSPCEEEAPASPAEDEHNQNGNLD


>Equus caballus_PDE1B
MELSPRSPPEMLESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLESGEVNIEELKKNLE
YTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPK
FRSIVHAVQAGIFVERMFRRTYTSVGPTYSAAVLNCLKNLDLWCFDVFSLNRAADDHALR
TIVFELLTRHNLISRFKIPTVFLMTFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLR
TGMVHCLSEIEILAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVF
RMMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKSMKTALQQLERIDKSKA
LSLLLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQ
IGFIDFIVEPTFSVLTDVAEKSVQPQADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSF
RSTWTKYIQENKQKWKERAASGITNQMSIDELCPCEEEAPSSPAEDEHNQNGNLD

>Xenopus tropicalis_PDE1B
MESPSVDKDLLEGCTSPFELKSAPSKKMWVKLRSLLKYMVKQLENGEVNIVELKKNLEYT
ASLLEAVYIDETRQILDTDDELPEMRSDSVPSEVRDWLASTFTQQTRSTGRRSEEKPRFR
SIVHAVQAGIFVERMFRRSYTAVGPNYSAAVVNSLKHLDLWDFDVFVLNRVSEDHALKTI
VFELLSRHNLNSRFKIPVAFLMSFLDSLESGYGKYKNPYHNQIHAADVTQTVHCFLLRTG
MVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSDCAILYNDRSVLENHHVSAVYRI
MQDDEMNIFVNLTKDEFTELRSLVIEMVLATDMSCHFQQVKTMKTSLQQLETIDKSKALS
LLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGLPFSPLCDRKSTLVAQSQIG
FIEFIVDPTFSVLTDVAEKTVLPLVEERSKSKSTASVNQSSSQWRQPSIDDHSEMGDINA
DIKSFRTTWTKYIQENKQKWKERAASGITNQTSVDELSPCEEQHSTEENGNLD

>Takifugu rubripes_PDE1B
MAELLRIRKKRLQIPISRLRSILKQLEEKNVDFEEIKKNLDFTASLLEAVYLDGTRQCLE
TEDDLQQLQSDGVPAEVTDWLASTFTRRVRQPARRSDEKPKFRSIVHAVQAGIFVERMFK
RAYTAALPDQPAAVVNCLRDVDRWSFDVFALNSASSDRALQTVFFELIARYGLNGRFKIP
ISCLTEFLSAVERGYCKHNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAA
AIHDYEHTGTTNNFHIHTKSEFALIYNDRSVQESHHLSAAFRLLQNEQMNIFVNLTREEW
MELRSLVIEMVLSTDMSSHLSQVKAIKACLQQQERIDKPKALSLLLHTADISHPSKPWPL
HSRWTKALMEEFFRQGDREAELGLPFSPLCDRNSTLVAESQIGFIDFIVYPTFSLLTDMA
EKIVIPLVEENPGPPDPCNRHSNLWRESSRGLQWSLAHITAELVSFRSTWTRHTEDNKFK
WKESGCNG

>Tetraodon nigroviridis_PDE1B
MAEMLRIRKKRLQIPISRLRSILKQLEEKNVDYEEIKKNLDFTASLLETIYFDGTRQCLE
TEDDLQQLQSDGVPAEVTDWLASTFTRRVRRPVRRSDEKPKFRSIVHAVQAGIFVERMFK
RAYTAALPDQPTAVVNCLRDVDRWSFDVFALNSASSDRALQIVFFELIARYGLNGRFKIP
ISCLTEFLSAVERGYCKYNNPYHSHVHAADVTQTLHCLLLRSGLVHWLTELEVMASLFAA
AIHDYEHTGTTNNFHIHTMSEFALIYNDRSVQESHHLSAAFRLLQNEQMNIFINLTREEW
MELRSLVVEMVLSTDMSSHLLQVKAMKACLQQQERIDKPKALSLLLHTADISHPSKPWPL
HSRWTKALMEEFFQQGDREAELGLPFSPLCDRKSTLVAESQIGFIDFIVYPTFSLLTDMA
EKVVIPLVEENPGPPDPCNRHSNLWRESSRGLQWSLAHITAELVSFRSTWTRHTEDNKFK
WKESGSNGMS

>Homo sapiens_PDE1C
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKR
SGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR
LAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGE
QQQNGDFKDGKNKTDKKDHSNIGNDSKKTDDSQE

>Mus musculus_PDE1C
MESPTKEIEEFESNSLKHLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLNSINSSDAKR
SGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKAR
LAAEEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDNPRGKNSKGEKAGEKQQ
NGDLKDGKNKADKKDHSNTGNESKKTDDPEE

>Rattus norvegicus_PDE1C
MTDTSHKKEGFKKCRSATFSIDGYSFTIVANEAGDKNARPLARFSRSKSQNCLWNSLIDG
LTGNVKEKPRPTIVQDTRPPEEILADELPQLDSPEALVKTSFRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSINSSDAKR
SGVKSSGSEGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKAR
LAAEEKQKEMEAKSQAEQGTTSKAEKKTSGETKGQVNGTRTSKGDNPRGKNSKGDKAGEK
QQNGDLKDGKNKADKKDHSNTGNESKKADGTKKRSHGSPAPSTSSTSRLTLPVIKPPLRH
FKRPAYASSSYAPSVPKKTDDHPVRYKMLDQRIKIKKIQNISHHWNKK

>Bos taurus_PDE1C
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAASVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SEEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQEDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDEPSQTGGTGQRRSSLNNISSTDAKR
SGVKSSGSEGSAPINNPVIPVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKAR
LAAEEKQKEMEAKSQAEESASGKAEKKTSGEAKNQVNGTRTNKSNNPHGKNSKTEKSSGE
KQQNGDLKDGKNKTGKKDQSDVGNDSKKTDGKSIIPIIFFHKMCNLMQAC

>Canis familiaris_PDE1C
MAKMLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVP
SEVRDWLASTFTRQMGMMLRRSEEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAV
IEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVG
YSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNF
HIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILINLSKDDWREFRTLVIEMVMA
TDMSCHFQQIKAMKTALQQPEVIEKPKALSLMLHTADISHPAKAWELHHRWTMSLLEEFF
RQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQ
TGGIGQRRSSLNSISSADAKRSGVKSTGSEGSAPINSSVIPVDYKSFKATWTEVVHINRE
RWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEEGAAGKTEKKTSGEAKNQVNGT
RTNKSDNPRGKNSKSEKSSGEKQQNGDLKDGKNKTDRKDQSNVGSDSKKTDDSEE


>Equus caballus_PDE1C
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SEEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPAAVIEALKDVDKWSFDVFSLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HLSAAYRLLQEDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIEKPKALSLMLHTADISHPAKAWELHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTAQRRSSLNNISSADAKR
SGVKSTGSEGSAPINNSVIPVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKDR
LAAEEKQKEMEAKSQAEEGAAGKAERKTSGETKNQVSGTRTNKSDNPRGKNSKAEKSSGE
KQQNGDLKDGKNKTEKKDQSNVGNDSKKTDGTKKRSQGSPAPSTSSASRLTLPVIKPALR
HFKRPAYASSSYAPSVPKKTDEHPARYKMLDQRIKMKKIQNISRTWNRK

>Monodelphis domestica_PDE1C
MESPIREIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEHAASVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR
SEEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFTLNEAS
GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH
HISAAYRLLQEDEEMNILSNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE
AIDKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS
TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDEPSQPGGPGHRRSSLNSISPSDAKR
SSVRSTGSEGSASINNNVLTVDYKTFKTTWTEVVHVNRERWRAKIPKEEKAKREAEEKAK
QEAEEKKKEMEAKSQAESEGAPGKPEKKKSGEGKSQANGGRPNPPGKPASKGDKAAHAGD
DKNKTDKKDQSNAGNDSKKADEPEKRPTNGGKYVETIGPK

>Ornithorhynchus anatinus_PDE1C
MIFRFPPAALYDSSTRAKEADSGGSKSQNCLWNSLIDGLTGNVKEKAKAAIIHDPRAPEE
ILADDLPQLDSPEALVKTSFRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRR
LLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSEEKPRFKSIVHAVQAGIFVER
MYRRTSNMVGLSYPPAVIEALKNVDKWSFDVFTLNDASGDHALKFIFYELLTRYDLISRF
KIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAII
FSAAIHDYEHTGTTNNFHIQTRSDSAILYNDRSVLESHHVSAAYRLLQEDEEMNILSNLS
KDDWREFRALVIEMVMATDMSCHFQQIKAMKSALQQPEEIDKPKALSLMLHTADISHPAK
AWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVL
TDMTEKIVTPLLDEPPQTGATGYRRSSLNNLSPSEAKRCSVKSTGSEGSTSLNSSVLAVD
YKTFKATWTEVVHVNRERWKAKVPKGELQGDKDKMEQSGFGSDSKKTDAFSATGSVDASE
HEDGCEWRGPTKAGNSTSIYVL

>Taeniopygia guttata_PDE1C
MESPTKEIEEFENNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLWSLLKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDDLSDIQSDSLPSEVRDWLASTFTRQMGMMLKR
TEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIGVLKNVDKWSFDVFALNDAS
GDHALKFIFYELLTRYDLINHFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVAQTV
HYLLFKTGTVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENH
HVSAAYRLLQDDEEMNILSNLSKDDWREFRALVIEMVLATDMSCHFQQIKAMKNALQQPE
GIDKSKALSLLLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRNS
TMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEASLSGMSGFRRSSLNSISPSEVKR
SSVKSTGSEGSASLNCSILTVDFKSFKATWTEVVQQNREKWKAQATKEEKAKKEAEGNAY
QGTDKKERDEQDGKPDEDVTERKTEKSKEPNPGESTRTDSSKNPGNGTWQRGMSKREAYQ
GGNATRTDKKMDHHHTLGEEKQHVQNGELTEDNKLDRKEV

>Gallus gallus_PDE1C
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKR
TEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIGVLKNVDKWSFDVFALNDAS
GDHALKFIFYELLTRYDLINRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLFKTGVVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENH
HVSAAYRLLQDDEEMNILSNLSKDDWREFRALVIEMVLATDMSCHFQQIKAMKNALQQPE
GIDKPKALSLLLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKS
TMVAQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIDEASRSGMSGFRRSSLNSISPSEVKR
SSVKSTGSEGSASLNCSILTVDFKCFKATWTEVVQQNREKWKAQATKGEIKEDCMADKKD
QSGVGSESKKTDGYIHRYFKKTDVVAWYLGHMASGDQQVTTKFTGHHNLTSDIVLHLLY

>Anole lizard_PDE1C
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD
LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDSVPSEVRDWLASTFTRQMGMMLKR
TEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIAVLKNVDKWSFDVFALNDAS
GEHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLFKTGVVHWLTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDTAILYNDRSVLENH
HLCAAFRLLQDDEEMNILSNLSKDDWREFRTLVIEMVLATDMSCHFQQIKAMKNALQQPE
GIDKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDKEAELGLPFSPLCDRKS
TMVPQSQIGFIDFIVEPTFTVLTDMTEKIVTPLIEEASHSGMTGFRRSSLNSISPSEVKR
SSVKSTGSEGSASLNCSILTVDFKCFKTTWTELVQQNREKWKAQATKEEKTKKETEENAQ
QGADEKKTEEREGKKQAEESSGTKTDKKASKSSVNGTHQTGDNKHEASQGKNITQVEKES
ESNPTAGQQKQVQNGELKNDNKSESKNQGNELRKSEGSKQHMKTAPVPDSTNRLTLPVIK
PPMHHLKKPNFASTSTTLPPFHMKTEDSLMKYKLLDQRDRMKKIQHISHHWNRK

>Danio rerio_PDE1C
MSELSSKKQGFKKCRSATFSIDGYSFTIGKNSWSASLATPPMRHRCFCLHSYRETGFFLP
DRADSLYRLPGAQHSPGLVHAAHDLTDCRHVAKAPLRLRCLVKQLERGEASVVDLKKNLE
YAASVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPR
FRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVITALKHVDTWSFDVFTLNDASGDHSLK
FIFYELLTRYDLINRFKIPVSALVSFVEALEVGYGKHRNPYHNLIHAADVTQTVHYLLLK
TGMVHWLTELEIFAMLFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRAVQENHHVSAAY
RLLQEDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPEGIDKPK
ALSLLLHTADISHPAKNWNMHYRWTTSLLEEFFRQGDKEAELGLPFSPLCDRKSTMVAQS
QIGFIDFIVEPTFTVLTDMIEKIMTPLIEEASPAGLAGFRRSSLNNIPSDGKRSSVRSTG
SEGGTSVNSSINAVDFKTFKSTWNEEVHKNREKWKAQAAKDLEEKAKQEEMEENEKKKDT
DTQSSDDNTKTEDKINTDSNAKSPDKQKEDTRPEKDSKTDQEDSGKAKVDNKEPTEQQPR
EKEGNKDPGGMNGAQTPSDGKEPETSSDTDNSQRVHNGSEELNSPDSDDSESKRSYDVSQ
WKRRSKCAKYLLSSADSEDEHSNCGISPSSDSAAAASAPHAD

>Takifugu rubripes_PDE1C
MESPTKEIEEFESTALKYLQPEQIEKIWLRLRGLRKYKKTSQRLRCLVKQLERGEASLND
LKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRR
NEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVISVLKNVDKWSFDVFALNEAS
GDHALKFIFYELLTRYDLISRFKIPISSLVSFVEALEVGYSKHKNPYHNLIHAADVTQTV
HYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRSVLESH
HVSAAYRLLQDDDEMNILYNLSKDDWRELRALVVEMVLATDMSCHFQQVKAMKNFLQQPE
GIDKPKALSLLLHTADISHPAKNWDLHHHWTTSLLEEFFRQGDKEADLGLPFSPLCDRKS
TMVAQSQIGFIDFIVVPTFTVLTDMMERIVTPLIDEASHSGFAGFRRSSLNSISSEEAKR
QSVKSVGSDSSSSGPGSLLTVDIKNFKAMWNEEVYQNRERWKAQACKEAEERAKREAEEQ
TQQEVEEEEPKSEASSSPQEANTGKMEQ

>Oryzias latipes_PDE1C
SKEEKVQVRLILRCLVKQLERGEASLNDLKKNLEYAASVLESVYIEETRRLVDTEDELSD
IQSDSVPSEVRDWLASTFTRQMGLMLRRNEEKPRFRSIVHAVQAGIFVERMYRRTSNMVG
LSYPASVISVLKNVDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISAVVSF
VEALEVGYNKHKNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEH
TGTTNNFHIQTRSDTAILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDWRELRAL
VVEMVLATDMSCHFQQVKAMKNFLQQPESIDKPKALSLLLHTADISHPAKSWDLHHRWTT
SLLEEFFRQGDKEADLGLPFSPLCDRKSTLVAQSQIGFIDFIVVPTFTVLSDMMERIVTP
LIEEASHSGLAGF


>Gasterosteus aculeatus_PDE1C
MESPTKEIEEFESTSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRCLVKQLERGEASLTD
LKKNLEYAALVLESVYIEETRRLVDTEDELSDIQSESVPSEVRDWLASTFTRQMGLMLRR
NEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVISVLKHVDKWSFDVFALNEAS
GDHALKFIFYELLTRYDLISRFKIPISAVVSFVEALEVGYSKHKNPYHNLMHAADVTQTV
HYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRSVLEHH
VSAAYRLLQEDDEMNILYNLSKDDWRELRALVVEMVLATDMSCHFQQVKTMKNFLQQPEG
IDKPKALSLLLHTADISHPAKSWNLHHRWTTSLLEEFFRQGDKESELGLPFSPLCDRKST
MVAQSQIGFIDFIVVPTFTVLTDMMESIVKPLIDEASHAGFSGFRRSSLNSISSEEAKRH
SVKSSDSSSSGHSSLLTVDLKNFKALWNEEVYQNRERWKAQAAKEAEERAKREAEEQAQQ
EEAMEPQEAHTEPE

>Tetraodon nigroviridis_PDE1C
LRCLVKQLERGEASLNDLKKNLEYAASVLESVYIEETRRLVDTEDELSDIQSESVPSEVR
DWLASTFTRQMGLMLRRNEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPSVISVL
KNVDKWSFDVFALNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKH
KNPYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQT
RSDTAILYNDRSVLESHHVSAAYRLLQDDDEMNILYNLSKDDWRELRALVVEMVLATDMS
CHFQQVKAMKNFLQQPEGIDKPKALSLLLHTADISHPAKNWDLHHHWTTSLLEEFFRQGD
KEADLGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMMERIVTPLIDEASHSGFS
GFRRSRHSLNSISSEEAKRQSVKSMGSDSSSSGPSSLLTVDIKNFKHVDEEVYQNRERWK
AQACKGEREQEQRCGCYLHR

>Apis mellifera_(XP_001120223)
MIDFTHHDLIQIKKVNIDSQFQFHRGLGRRCREVLSCAKKRLQKSAEVASPPDRRATRDD
IAVSSPGASPNVNATTSCTGTTSSRLHNPSSPGRNGQLSKQGTLTIVRRSSGKNKSIGGS
FESSPPPHSPDTLSSSQSVDLDEILDNVDLTTDSLPAVDTPDACDKAALRLRCLLRQLQH
GEISAELLQRNLHYAARVLEAVFLDETKDYINATTRYRPLDAEIIISQKQVSQRGCSIDS
ISSQPMNPSPGTGLSSASLGSALDSDGQQGHAVVTQKRKLRTPVWARLLSTNKTRLADED
DELSEVQPDAVPPEVREWLASTFTRQLATTRRKADEKPKFRSVAHAIRAGIFVDRIYRRV
TNTALMQFPQEVVKVLKTLDDWSFDVFSLNEAAMGAPVKYLGYDLLNRYGMIHKFKVPAT
VLECFLGRVEEGYCRHRNPYHNNLHAADVAQTMHYILCQTGLMNWLTDLEIFATLVAAII
HDYEHTGTTNNFHVMSGSDTALLYNDRAVLENHHISASFRIMREDECNILQNLSREEFRE
FRSLVIDMVLATDMSFHFQQLKNMKNILSLAEPSVDKSKAVSLVLHCCDISHPAKRWDLH
HRWTMQLLEEFFRQGDKEKALGLPFSPLCDRNNTLVAESQIGFIEFIVEPSMQVCSDMLE
TVLTPLNVKESVDESNNGSGGESRRFKIGKPWIPCLAENKRIWKEQAVRGIWNKILVRCV
EFDIVVLKRNT

>Drosophila melanogaster_(NP_001137817)
MGDTLDETPPTRRDKPQTLNIGQEEQGSDPASGNTSSPVSSIAIPAARVPRHRLRHADRD
QKRDHSSDGLVSSGELRDEFMGIDAQPRRESLNSCEVGSPGTMSSSLGKAGRLNSSRYPS
GGAGAIGLSVMGNLVGTTTRKCVLTLDGYSYVIVASTPESLPSKRDEASGGPGSSGGTSG
AATSSSSSGGGAASGAASGSVGPASGTATGTGSASGGAGGVSTPAQEAASPTVSELSGSG
SNATINGQVARHGSLTIIRRTNSRNFTQFDGQLASPSSTACSSTAPGIGFAQTPLSEPLA
ERLSFRASGGSNGSASAGDSRSSNQGPSNSGPAASAAVKMQPSSPNATNYLADNIQISSA
NLSQTEMVVGRDSADYTAMHSINVGVGNSFLRGDTDIPQESGHSFETPSNMSFTAGQWDT
ESLPPVDTPDALNKAAGRIRSLLRRMDHETVAYEDMQRNLHYAARVLEAVFIDESREGCN
GNCKNLNCSRHSHGRDDQQQDNNNSNRSCSLQEASPGGAGAGVTPGADNQDSIESRTKGV
SQAPQTHSGPTGPPSNTSSETIAQPAPKLQPALETVRESVMEESPSKDPGDKGPPPPAST
STLTSQTTTSSSATAEPSAKAAESQAGSAGSSGSCSNPAAVHRQRRLRTPTWARSMSTNK
TRLADEDDELSEVQPDAVPPEVREWLASTFTRQMATSRRKSDEKPKFRSVAHAIRAGIFV
DRMYRRVSSSALTAFPPDVVRLLKNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIH
KFKIAPGILEAFLHRVEEGYCRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFA
SLLAALLHDYEHTGTTNNFHVMSGSETALLYNDRAVLENHHASASFRLLREDEYNILSHL
SREEFRELRGLVIEMVLGTDMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHP
AKQWGVHHRWTMLLLEEFFRQGDLEKELGLPFSPLCDRNNTLVAESQICFIDFIVEPSMG
VMSDMLELILAPIAPMNKSKPATLVEHETTANSTTNSAIVIPNSGITPSMDKPRDHRTEA
KTTAAECLARKSVTGTTASKFNIPKPWLTCLVENKRIWKEQAVKDAEARALATAAEEAAA
AAAAEAEESKPETETADGEQSEPAAEPADGAAA

>Strongylocentrotus purpuratus_(NP_001091918)
MEGKPNPTEKGKSHVANPPNNANANKESPGSPRARVEGKKMEYRIIKKTDTKRRLRRQES
QSMDEESLASIDLEVSESMPPATSPQGAVLAALRLRSLVLRLEREEISKKYLKENLEYAA
SVLDTLKQDEASRYHYHEEEDDLSEVTSDEVPEQVRHWLTSTFSRQSTKSRLGDEKPRFR
SIVQALRTGLFIDRMFRRTSATAGTVLPAKVIQIFKTIDDWSFVDDWSFDIFLLDTETDG
HALKFLATEVLSRYDLQTKFKIPHSVLGAFLDAMELGYSKYGNPYHNLLHAADVTQTVHH
MLARMGLVHWLSDLEIFASLLAAIIHDFEHTGTTNAFHVNTKSDMAMFYNDRAVLENHHI
SSSFRLMRDDERNILANLSKEEYTELRNLVIDMVLATDMSFHFQQIKQMKSMISTTEALD
KPKVMALTLHCADISHPSKEWKFHYKWTTLLIREFFRQGDREREMGLPISPLCDRNSTLL
AESQIGFIDFIVDPSMNICGDMIDRILREELNSASNSPSADSVVRNKRNSIPMARPCSAP
RSASVPAPANNNSMNDRDRPSSPGRVSIGRRNSIPVRCLRSWHENLHKNKSKWRDFGQQE
HTGVKVLDIDEDPIVQKPNKDVFHKSDTNDDSAARKTSNANGIEEEEAPHDQATTSGSTA
GAAESSGSAHAPGRQGSGER

>Anopheles gambiae_(XP_319716)
QTQNNRRLADEDDELSEVQPDAVPPEVREWLASTFTRQLATTRKKSDEKPKFRSVAHAIR
AGIFVDRIYRRVSSTALMQFPPEVVRVLKTLDDWSFDVFALAEAGNCQPVKYLGYDLLNR
YGMIHKFKVPPATLETFLTRIEEGYCRFRNPYHNNLHAADVAQTVHHVLCQTGLMHWLTD
LEIFATLLAALIHDYEHTGTTNNFHVMSGSDTAMLYNDRAVLENHHISAAFRVLKEDDCN
VLQNLSRDEFRELRTLIIDMVLATDMSFHFQQLKNMRNLLTLAEPQVDKSKALSLVLHCC
DISHPAKRWDIHHKWTMLLLEEFFRQGDLERELGLPFSPLCDRNNTLVAESQIGFIEFIV
EPSMTVCADMLEIVLAPIAPI

>Ciona intestinalis_(XP_002123743)
ESNSVSSEHIRQNIEYAIAVMESRYVNRIADISDDEVPATLSGEGPVPPEIKRWLVQTFT
SHTRNRKESENKRSLRSVVHAVQAGMFVDRMFRKTSVGPMFKTYSKVTYSIQNIDSWSYN
VFELERISEGNSLKFVFYELLNKYDLIRKFKIPLKSLFAYCTKLQRGYRKHNNRYHNPIH
AADVAQSLNCLLVNSGFVHWLSDVEMFSMIMAAIVHDLEHSGTTNTFHTNTRSPLAQMYN
DKSVLENHHISSAFRLLNEEDCDILANFSKDDYQEARTLMIDMVLATDMSQHFGQLKRLQ
SNLQHPENLEKSRAMCLMIHSADINHPSKPWNLHCRWTERLVVEFFEQGDQERGLGLPLS
PLCDRHTTMVAQSQIGFIDYVIKPTFDVLYDI

>Ciona savignyi_(ENSCSAVP_11923)
EHIRRNIEYAIAVMESRYVNRVVEIPDDEVPATLSGEGPVPPEIKRWLVQTFTSRRADVR
GRKESETRRSLRSVVHAVQAGMFVERMFRKTSVGVQNLPPEVQEHFKNIDSWSYDVFELD
RISDGNSLKFVFYELLNKYDLIRKFKIPLKSLFAYSARLQRGYRKYNNRYHNPIHAADVA
QSLNCLLVSSGFVHWLSDLEMFSMIMAAVVHDLEHSGTTNTFHTNTRSPLAQMYNDKSVL
ENHHISSAFRLLNEEDCDILVNFSKDDYPSKEARTLMIDMVLATDMSQHFGQVKKLQSNL
QHPESLEKSRAMCLMIHSADINHPSKQWELHCRWTERLVVEFFEQGDQERKLGLPLSPLC
DRHTTMVAQSQIGFMDYVIKPTYDVLFDIFRNVNGPVVRDAILSLRRAS

>Branchiostoma floridae_(XP_002217565)
MSCGILHVCLHRKLVPDEDDLSEVEPDAVPTEVRDWLASTFTRQMQVSTRARTEKPRFRSIVQAVRACNR
VDRLCRKLSGSGVNYPPGVVNLLKNLDDWSFDVFAVNVASNSQALRYVAYEVLKTYDLLVKFKINSGVLF
KFLDALESGYGKHSNPYHNQLHAADVTQTTHYLLYSTGLVQWLADVEILAVVLSAAIHDVEHTGETNSFH
VMSKDVWCIRTMLYNDRAVLENHHISTNESWVSASQMSQMGTLRTLTIDMVLATDMSFHFQQVKQIKSLL
SCPESIDKSKALSLLLHTADIGHPAKPWHLHARWTEQLMEEFFRQGDKEKALGLPFSPLCDRNTTVIADS
QIGFIDFIVDPTFQVMGDMLEKILTPLAP

>Branchiostoma floridae_(XP_002250062)
MFSSFYEFLLFLYDVAIVCIMVMCVIYINYVIVTRWIPVLIGFAWRLVQEYLPPHISRKGDIILTQIEAD
YYAFIDWFEGLRYKLKEWWYREPVVEPVEEDSGEERRRSSVDLSLITAMITSQTASSEEKQNGGQTIVKV
ANSGEKNAVENDTQGCSVQPLKASSSNESVSGKRLTPRKKGSPPRRQGPSKEDLTMSLELCTDNLPPTDS
LEALEKASKRIRKICTFLQSRGNVPSNLLKRNLHYIADVLEIVATDDARRFIDEDDELSEVEPDAVPMEV
RDWLASTFTRSASVTKSGEKEKKTFRSIVQAVRAANLSLDDWSFDVFALNEATNGQALRYVTYEIMMRYD
LLAKFKIGVGTLFNFLEALEVGYSKYQNPYHNLVHGADVTQTMHSILFQTGLVQWLTDVEIFAVVFSAAI
HDFEHTGETNNFHVMSRDFRTLVIDMVLATDMSYHFAQVKQMKSLLSCPDNIDKAKALSLVLHTADISHP
AKNWTLHEHWTELLMEEFFRQGDKEQELGLPFSPLCDRKTTMVASSQIGKYSKGGFIDFIVQPSFEIMSD
MLDKVVAPISPRGSLANQSSATISEKVEAEGSPQNGDQSEEPFEFKVDRVWDGHLTGNKVKWKEQSTKDQ
AEKEAREKAAQKAKEDAEKRDQSPLDDKAEEKKDAENPPKITANGTVSPGNAVDLKVKPSTSPENDDQVS
TKEEAVGTASPEHAEKRTTEEDKPGKIESITVKSVTKRKESGV

>Nematostella vectensis_(XP_001629364)
EIDENLENELDSVNEEVREWIATTFARGPGAARRKSMVRRHTFRGVVHAVKASLYVNKMLKNATERYKMH
VPENVQKAFEWTFDVFALSESCEGHPLRYIGYEVLHRRDMLRNFKIHAMTLDRFLQDVETGYKRHSNPYH
NDCHAADVTHTVHYFLECMGVSKYLSDLEVFGLLLSAIIHDLEHTGTTNAFHINSRSDLALLYNDRSVLE
NHHVSCAFRILQDDEKNILSGLNLEQYADVRSLMIDTVLATDMSSHFEQLRLMKVALVAGSPIENREVVQ
LLLHVADISNPTKDWTIHRQWTTKIMEEFFTQGDMEIELGLDVSPLCDRSTTLIPESQIGFIDFIVSPAL
EVCSEVLE