>Homo sapiens_PDE2A(ENSP_334910) MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE >Macaca mulatta_PDE2A(ENSMMUP_19727) QDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKV WFTDQDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQPPRPIQKGNAHVFLDCLMTWRP AVAQDPRHCPQALYCSIWALQQHQLELVFDGGVVDDESYEIRIPADQGIAGHVATTGQIL NIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDL ATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAI DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYH NWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLA ALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRI FKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDL EKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWT KVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE >Mus musculus_PDE2A(ENSMUSP_127521) MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAG LRQAARDALSAVLPKVETVYTYLLDGESRLVCEDPPHELPQEGKIREAVISQKRLSCNGL GPSDLLGKPLARLVAPLAPDMQVLVIPLLDKETGSVAAVILVHCGQLSDSEEQSLQVVEK HALVALRRVQALQQRRPEAVQNTSVDASEDQKDEKGYTDHDRKILQLCGELFDLDATSLQ LKVLQYLQQETQATHCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTMGRLGQVVEDKQC IQLKDLTSDDVQQLQNMLGCELQAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDEHV IQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLS NAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHP LFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCG ISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTY TPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVS HFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSV MERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAE VGYDRNNRQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPM EMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIR GLPSNNSLDFLDEEYEVPDLDGTRAPVNGCCSLE >Felis catus_PDE2A(ENSFCAP_12233) MGQACGHSILCRSQQYPAARPAEPVLSRGWGLXXPPPPPQPCADSLQDALLSLGSVIHIA GFQRAVKEALSAVLPKVETVYTYLLDGESRLVCEDPPHELPQEGKVREAVISRKRLGCNG LGPSDLPGKPLARLMAPLAPDTQVLVMPLVDKEAGAVAAVILVHCGQLSDSEEWSLQAVE KHALVALRRVQALQPRGPGAASAAVRNPPAGVAGDQKGGVAHTDQDQKILQLCGELYDLD ASSLQLKVLQYLQQETQASRCCLLLVSEDNLQLSCKVIGDKVLEEETSFPLTTGRLGQVV EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLGGDLFTD QDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL QKMAEVGYDRTNKQHHSLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH KFTIRGLPSNNSLDFLDEEYEVPQLDGTGAPVNGCFSLDAE >Anolis carolinensis_PDE2A(ENSACAP_2806) FQVSDDEYTKLLNENILPVSNIDTDFAKFTYTPRSLPDDDTSMAILSMLQDMNFISSYKI DRQTLVRFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELVNYLEDIEIFALFISCM CHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTQGCNIFDHFSRKDY QRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDPKNKQHHSLLICLLMTSCDLSDQTK GWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL QDLFPRSAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYDLQTMGEDSEDSIR MNGCLEDGHLEEGEELE >Takifugu rubripes_PDE2A(ENSTRUP_23076) QDALLRLAAVVDVHSLRAAFRDSVQDLLPHTECVCVYMLDGESRLICDEPPHELPKEGKI RSIVNQLNRRQCNGLPLSELPEKYRACLAAPLPAHRRAIIIPILDQKQSEAIAVLLVGCN SLSDQDEVHLNTLEKHTLVAHKRMNKITLPASSLPPQASSQPFFRTVHDALLHLDISGHD YSQLDRDILQLCGELFDLDAASLQLKVINYLQQQTQSECCCLLLVSEDNHQLFCQVVGDK VLEEEISFPLTFGHFGQVVQKKQSITLQDITAEECRQMSTMLGCKIMSMLCVPVASRATG QVVALACAFNKQGGQRHTEADEHAIQHCFCYTSTVLTSTLAFQKEQKLKVECQALLQVAK NLFTHLDDVSVLLQEIIVEARNLSGAEICSVFLLDRLSHELVAKVFDGGVVSDEEKEFRI PADQGIAGHVATTGQILNIKDAYSHPLFYRGVDDSTGFRTRNILCFPIKDETNEVIGVAE LVNKMNGPWFNRFDEDLATAFSIYCGISIAHSLLYKRVHEAQFRSHLANEMMMYHMKVSG EEVSKLLVSGIEPIKEIDPCFAEFTYTPRSLSDDSTPMCVLSMFEDMGFINTYKIDLHTL ARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLGLSRYLQDIEILALFVSCMCHDLD HRGTNNSFQVASQSVLAALYSSEGSVMERHHFAQAIAILNTVGCNIFEKFSRKDYQRMLD LIRDIILATDLAHHLRIFKDLQKMADDGYNPKSQTHRSMLLCLLMTSCDLSDQTKGWKTT RKIAELIYKEFFSQGDLEKAMGNRPSEMMDREKAYIPELQISFMEHIAMPIYKLLSELFP GAAELYERVAANREQWTKVSHKFTIRGLPSNNSLDFLDQEYELLQSEGALTSDDQCLNGC LDDAE>Homo sapiens_PDE5A(ENSP_347046) MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPL NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTME PLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE LVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN >Macaca mulatta_PDE5A(ENSMMUP_9576) MERAGLSFGRQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAE RVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEG TVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLI SADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAALGEPL NIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDE KDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIIS FMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDMLTREHDTNKINYMYAQYVKNTME PLNIPDVSKDKRFPWTTENTGNVSQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGK VKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETREL QSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWIL SVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGV NNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAI LATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAE LVASEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCF PLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN >Mus musculus_PDE5A(ENSMUSP_69011) MERAGPNSVRSQQQRDPDWVEAWLDDHRDFTFSYFIRKATRDMVNAWFSERVHNIPVCKE GIRAHTESCSCSLQQSPHADNTTPGAPARKISASEFDRPLRPIVVKDSEGTVSFLSDSGK KEQMPLTPPRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLV CEDSSKDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYEDPR FNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFC GIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIF IVDEDCPDSFSRVFHMECEEVGKPSDPLTREQDANKINYMYAQYVKNTMEPLNIPDVTKD KRFPWTNENMGHVNTPCIGSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKIKAFNQNDEQ FLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALSAAVVPS AQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNV AYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEH PLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIDEYKTTLKIIKQAILATDLALYIK RRGEFFELIRKNQFSFEDPLQKELFLAMLMTACDLSAITKPWPIQQRIAELVAAEFFDQG DRERKELNMEPADLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCLPLLDGCRKNR QKWQALAEQQEKMLLNGESSQGKRD >Felis catus_PDE5A(ENSFCAP_9620) MVNAWFAERVHTIPVCKEGIRSHTESCSCPSQQSPRADSSAPGTPTRKISASEFDRPLRP IVVKDSEGTVSFLSDSEKKEQMPLTPPRFDNDEGDQCSRLLELVKDISSHLDVTALCHKI FLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEASNNCIRLEWNKGIVGH VAAFGEPLNIKDAYEDPRFNAEVDQITGYRTQSILCMPIKNHREEVVGVAQAINKRSGNG GTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQAKVLLDLASLIFEEQQSLEVI LKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTRERDANRINYM YAQYVKNTMEPLNIPDVSKDKRFPWTNENTGSVSQQFIRSLLCTPIKNGKKNKVIGVCQL VNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHA SAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM KHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLETLALLIAA LSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYK TTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITK PWPIQQRIAELVATEFFDQGDRERKELNIEPADLMNREKKNKIPSMQVGFIDAICLQLYE ALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESSQAKRN >Gallus gallus_PDE5A(ENSGALP_19524) MERSCHPSPEQEAVEAWLDDHCDFTRSYFVRKATREMVNAWFAERVHTIPVCKEGTKSQS ESCACQQLACSENTNSGTPARKISASEFDRPLRPIFVKDSVGAVSFLSGSEKKEQMPLQS PRTGTSAGDRCSRLLELVKDISSHLDVTALCHKIFLHIHELIAADRYSLFLVCEDSSNEK FLVSRLFDVAEGSTLEEASNNCIRLEWNKGIVGHVAAIGQPLNIKNAYEDPRFNAEVDQI TGYKTQSILCMPIKNHREEVVGVAQAINKKSGTGGTFTEQDEKDFAAYLAFCGIVLHNAQ LYETSLLENRRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQRCTIFIVDEDCTD SFSSVFHMEAEELEDSAENQKRDCDTNKINYMYAQYVKNTMEPLNIPDVCKDRRFPWTTD SAESVSQHIKSLLCTPIKNGKKNKVIGVCQLVNKMEENSGKIKAFNRNDEQFLEAFVIFC GLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEESRELQVTAAAVVPSAQSLNLTDF NFSDFELSDFETTLCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAF NTAQCMFAALKSGKIQSKLTDLETLALLIATLSHDLDHRGVNNSYIQRSEHPLAQLYCHS IMEHHHFDQCLMILNSPGNQILSSLSIEEYKATLKMIKQAILATDLALYIKRRGEFFELL RKKQFNWEDPMQKELFLAMLMTACDLSAITKPWPVQQRIAELVATEFFDQGDKERKELNI EPTDLMNREKKNKIPSMQVGFIDAVCLQLYEALTHVSEACYPLLDGCRKNRQKWQSLAEQ QEKNLINGESNQAKRN >Anolis carolinensis_PDE5A(ENSACAP_13103) KAWILLFWDFLLNLLRERRGREMVNAWFSERVHTIPVCKEGTKTHSETCSCSTLQTTRSE NTNSTPPARKISASEFDRPLRPIVVKDSIGTVSFLSDSEKKEQMPLQSRTLRTDAGDQCT RLLELVKDISSHLDVTALCHKIFLHIHELIAADRYSLFLVCEDSSNEKFLVSRLFDVAEG TTLEEASNNCIRLEWNKGIVGHVAALGQPLNIKDAYEDPRFNAEVDQITGYKTQSILCMP IKNHREEVVGVAQAINKKSGGGGTFTEQDEKDFSAYLAFCGIVLHNAQLYETSLLENRRN QVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQQCTIFIVDEDCSDSYSSVFHMEFEE LEDSNETHKRDYDTNQINYMYAQYVKNTMEPLNIPNIRQDKRFPWTPFNVNNVNAQKVCP KQLLLTTEKELGEKNETPNDPGVCQLANKMEENSCKIKAFNRNDEQFLEAFVIFCGLGIQ NTQMYEAVERAMAKQMVTLEVLSYHASAADEEARELQVTAAAVVPSAQSLGLTDFYFSDF ELSDMETSLCTIRMFTDLNLVQNFQMKHEVLCRWILSVRKNYRKNVAYHNWRHAFNTAQC MFAALKSGKIQNKLTDTEVLSLLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHH HFDQCLMILNTPGNQILSGLSVEEYKATVKMIKQAILATDLALYIKRRGEFFDLLRKKQF NLEDPYQKELFLAMLMTACDLSAITKPWPVQQRKTQIAELVAAEFFDQGDKERQELNIEP TDLMNREKKNKIPSMQVGFIDAICLQLYEALTHISEACYPLLEGCRKNRQKWQALAEQQE NNLINGESNQPKRN >Xenopus tropicalis_PDE5A(ENSXETP_8757) QVVGVAQAINKKSGSNGTFTDQDEKDFAAYLAFCGIVLHNAQLYETSLLENRRNQVLLDL ATLIFEEQQSLEVILKKIAATILSFMQAQRCTIFIVDEDSPDTFSSVFHMESDELEESAD AVKREYDVSKMNYMYAQYVANTMEAINIPDICKDTRFPWTNGNEEKNFKHIQSLLCSPIK NAKKNKVIGVCQLVNKVDENSGKIKAFNKNDEQFLEAFAIFCGLGIQNTQMFEVVERAMA KQMVTLEILSYHASAAEEETMELQVTAGAIVPSAQSLKLTEFYFSDFELSDMETTLATSR MFTDLNLVQTFQMKYEKTLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALRTGKIQG KLNDLEILALMIATLSHDLDHRGVNNSFIQRSEHPLAQLYCHSIMENHHFDQCLMILNSQ GNQILSGLSVQDYKTVLKMIKQAILATDLALYIKRRSDFFELVNKKKFKWDDPSQKELFL AMLMTACDLSAITKPWPVQQRIAELVASEFYDQGDKERRELNIEPIDLMNREKKDKIPSM QVGFIDAVCLELYEALTQISESCYPLLDGCQRNRQMWQILAEQQEKNLVNGAKSQPEVKC NMD >Danio rerio_PDE5A(ENSDARP_68115) MEVYPSDSERMMEAWLDDNLEFAHSYFVRKASREMVNAWFAERVHSIQPSREPSKAVPEP VTAVHSLGPTDVVPSSSPAPSTPTRKISASEFDRPLRPIVVKDAEGSFTFLSDTERVQMP LPPSQRPGSDNGTDEGGGIRDRGNGDRCARLLELVRDVSSHLDLTALCHKIFLHTHELIA ADRYSLFLVGEDSSNRKFLVSRLFDVAEGSTLEESSNSGIRLEWNKGIVGYVAATGQPLN IKNAYEDSRFNAEVDQITGYKTQSILCLPIKNHRDEVVGVAQAINKKCGENSTFTEQDEK DFSSYLAFSGIVLHNAQLYETSQLENRRNQVLLDLASLIFEEQQSLEVLLRKTVATILSF MQAQECTVFISDRETANTFASVFHMEYEEIAGSTDFPNRECDVNKINYMYAQYVKNTMET LNITDTTKDQLFSWTSEDPQSTNCQIKSLLCTPIRNGKKDKVIGVCQLVNKMDEASGEVK AFNRNDEQFLEAFAVFCGLGIQNTQMYEAVERAMAKQEVTLEVLSYHASAAEEETRALQV TAAATIPSAQSLRLMDYSFSDFDLTDAETTQATIRMFVDLKLVQNFQIKYKSLCQWILSV KKNYRKNVVYHNWRHAFNTSQCMFAVLKSGRVQNNLSDLETLALMIATLSHDLDHRGVNN SYIKRSDHPLAQLYCHSTMEHHHFDQCLMILNSPGNQILSGLSLDEYKATLKMIEKAILA TDLAVYMKKRTEFFELAKNSQFEWEDDCHRDLLRSMLMTACDISAITKPWPVQKKIAELV ATEFFEQGDKERRELNIEPIDLMNREKQDKIPSMQVSFIDAICTQLYEALTGISEFCSPL LEGCRKNRQNWKILAEQGEEAALLNGEL >Takifugu rubripes_PDE5A(ENSTRUP_25606) ESERMEAWLDDHLEFTRSYFIRKASREMVNAWFAERVHSIHPSAPKENPPQHPRTQQSSA DSAVTAPSPVPGTPTRKISASEFDRPLRPIVVKDAEGSLTFLSDADRETVPVRAAAMGEG GGVHVGGCDEAGSWCGRDRCARLLELVKEVSSHLDVTALCHKIFLHINELIAADRYSLFL VGEDSSNRKFLVSRLFDVAEGSTVEESSSSCIRLEWNKGIVGHVAATGQPLNIKNAYEDS RFNAEVDLITGYKTHSILCLPIKNHRDEVVGVAQAINKKSGDDAAFTDQDEKDFSAYLAF SGIVLHNAQLYETSQLENRRNQVLLDLASLIFEEQQCLKVLLRKFAGTILSFMQAQACTV FIADEDSMNSFSSVFHMEYEELGEVLDVPKRDCDVSQINYMYAQYVKNTMQTLNIADVTK DQRFPWTGENPDHTNDQIKSLLCTPIRNGKKDKVIGVCQLVNKMDEASDSVKAFNRNDEQ FLEAFAIFCGLGIQNTQMYETVERAMAKQEVTLEVLSYHATASEEESRELQVTVVATVPS AQSLRLLDFSFSDFELSDTETTLATIRMFVDLNLVQNFQMKYMNLCRWVLSVKKNYRKSV AYHNWRHAFNTAQSMFALLKSGRLQNNLNDLEVLALMIATLSHDLDHRGVNNSYIQRSDH PLAQLYCHSTMEHHHFDHCLMILNSPGNQILSSLSLDEYKSTLKMIERAILATDLALYMK RRGEFFELTKNSQFVWEDEQHRDLLRSMLMTACDISAITKPWPVQQRIAELVATEFFEQG DKERRELNIEPSDLMNREKKDKIPSMQVSFIDAICTQLYETLAGMSEYCSPLLEGCQKNR QQWKHLAEECEKGLVNG >Oryzias latipes_PDE5A(ENSORLP_25741) SLCQWILSVKKNYRKSVAYHNWRHAFNTAQCMFALLKSGRLQNNLSDLEILALMIATLSH DLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMILNTPGNQILSGLSLDEYKATL KMIEKAILATDLALYMKKREDFFELTKNNQFVWVDEHHRDLLRSMLMTACDISAITKPWP VQKRVAELVATEFFEQGDKERRELNIEPTDLMNREKRDKIPSMQVSFIDAICIQLYETLA GLLEHCSPLLEGCQKNRQHWKRLAEDCEK >Homo sapiens_PDE6B(ENSP_420295) MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY SGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC NGGPAPKSSTCCIL >Macaca mulatta_PDE6B(ENSMMUP_40713) MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDRCPPDCNSFRELCQVEESEALL ELVQDMQENINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVKDVAEQCPHFSSFADELTDYKTKNILATP IMNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLDLKIYHLSYLHNCETRRGQVL LWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWPVLMGESQP YSGPRTPDGRELGHSPLHTHVQPGLVPLTPAHTTPPADHWALASGLPSYVAESGFVSPVL SGAPTALPSLGEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLM ESLTQFLGWSVMNTDTHDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPA DCDEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQE VLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHD IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIH LMDIAIIATDLALYFKKRAMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACD LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPHVDQNKAAELPKLQVGFIDFV CTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKGVGRGHTKQEGTNRAVGTE ICNGGPAPKSSTCCIL >Mus musculus_PDE6B(ENSMUSP_31456) MSLSEEQVRSFLDGNPTFAHQYFGKKLSPENVAGACEDGWLADCGSLRELCQVEESAALF ELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGIAELATRLFSVQPDSLLE DCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSSFADELTDYVTKNILSTPI MNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATLNLKIYHLSYLHNCETRRGQVLL WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWPVLMGEAQPY SGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALASGLPTYVAESGFICNIMNA SADEMFNFQEGPLDDSGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMES LTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADC EEDELGKILKEELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVL VRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLM DIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLS AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKVGTE VCNGGPAPKSSTCCIL >Felis catus_PDE6B(ENSFCAP_7623) MSLSGEQVQQFLDQNPSFADEYFGKKLSPENVAGAHEDGQPVDCASFRELCQVEESTALF ELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGVAELATRLFSVQPGSVLE DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNIKDVTECPHFSSFADELTDYVTKNILATPI MNGKDVVAVIMAVNKLDGPCFTSEDEDVFLKYLNFGTLNLKIYHLSYLHNCETRRGQVLL WSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEAQPY SGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALASGLPTYVAESGFICNIMNA PADEMFKFQEGPLDDSGWTIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES LTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQLVLPTRERLGKEPADC EEDELGTILKEVLPGPNKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVL VRFLFSVSKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM DIAIIATDLALYFKKRTMFQKIVDESKNYEDRKSWVEYLSLETTRKEIVMAMMMTACDLS AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEEKQQQEERTTVKKGGTE ICNGGPAPKSSTCCIL >Gallus gallus_PDE6B(ENSGALP_32161) MSISEDDVEKFLDGNPAFAKQYFEKKLKTESCDDNESEILFELIQDMQESINMEKVVFKT LRRIRSLIHADRCSLFMYRQRNGTPELATRLFNIQEGSTLEECLVSPDCEIVYPLDLGIV GYVAQTKKTMNIKDVSECPQFSSFVDELTDYTTKSILATPILNGKDLVAVILAINKLNGP FFTNSDETLFLKYLNFASLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHK AFYTVRAYLNCDRYSVGLLDMTKQKEFFDLWPVLLGEVPPYSGPRTPDGREIVFYKVIDY ILHGKEDIKVIPNPTPDHWALVTGLPTYVAESGFICNIMNAAADEMFNFQEGPLDESGWT IKNVLSMPIVNKKEEIVGVVTFFNRKDGKPFDEQDETLMESLTQFLGWSVLNTDTYDKMN KLENRKDIAQDMVLYHVKCDKDEIQEILPTREKLGKEPSECEEEELASILKEQLPGPTKF EIYEFRFSDFDCTELELVKCGIQMYYELGVVKKFQIPQEVLVRFVYSVSKGYRKITYHNW RHGFNVAQTMFTLLMTGKLKRYYTDLEAFAMVTAALCHDIDHRGTNNLYQMKSQNPLAKL HGSSILERHHLDFGKFLLSEESLNICQNLNRRQHEHMIHLMDIAIIATDLALYFKKRTMF QKIVDESKTYDNTTAWTDYLSLETTKKEVVMAMMMTACDLSAITKPWEVQSKVALLVAAE FWEQGDLEISVLQQQPIPMMDRRKAAELPKLQVGFIDFVCTFVYKEFSRFHEEIQPMLDG LLNNRNEWKTRADEYDAKMKALEEEKKKEEEKMAAQKDGITCNGGTAPTSKTCSIL >Anolis carolinensis_PDE6B(ENSACAP_1148) MSVNKDEVETFLDNNLDFAKQYFERKLGDKTLCATASFHQCSEDGVDFGGLGQNETETLF ELIQDMQESINMEKVVFKTLKRISVLIQADCCSLFMYRQRNGTPELATRLFNIRKDSTME ESLVAPDCEIVFPLDMGIVGYVAQNKKTVNIQNVDECDYFSTFVDELTGYTTRNVLATPI MNGKEVVAVIMAVNKSGAQFFSSADENLFLKYLNFAALNLKIYHLSYLHNCETRRGQVLL WSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMSKQKEFFDLWPVLMGEVPPY SGPRTPDGREIAFYKVIDYILHGKEDIKVIPNPKPEHWALVSGLPTYVAETGFICNIMNA ASDEMFAFQEGPVDESGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEILMES LTQFLGWSVLNTDTYDKMNKLEYRKDIAQDMVLYHIKCDKNEIQAILPTREKLGKEVSEC DEEELAAILKEQLPDPEEYEIYHFHFSDLEWTEFDLVKCGIQMYYELGVVKKFQIPQEVL VRFIFSVSKGYRKITYHNWRHGFNVAQTMFTLLMTGKLKQYYTDLEALAMVTAALCHDID HRGTNNLYQMKSQHPLAKLHGSSILERHHLEFGKFLLSEESLNIYQNLNRRQFEHVNNLM DIAIIATDLALYFKKRTMFQKIVDESKTYDNEKEWAEYLSLEATKKEIIMAMMMTACDLS GIAKPWEVQSKVALLVAAEFWEQGDLEISVLQQQPIPMMDRRKAAELPKLQVGFIDFVCT FVYKEFSRFHPQIQPMYERLLNNRKEWKALADDYDANMKALEEKRKEEEAKTVNSKGAIL TCNGESVPPSSTCCII >Danio rerio_PDE6Ba(ENSDARP_123023) MSVKKEDVEKFLDGNPDFTKTYFDKKLKPGAVASIMRVPESKVDMDSFKEIVSVEEGAIF YDLITDMQENVNMEKVIFKILKRISALIHADRCSLFMYRQRNGIAELATRLFNVNKDSEL DDCVVAPDSEIVFPLDIGIVGHVAQTKKQVNVKDVTQDSHFSTFVDELTEYTTHNLLAAP IMNGKDVVAVIMAVNKTTGPHFTDEDMDLFLKYLKVGSLNLKIFHLSYLHNCETRKGQLL LWSANKVFEELTDIERQFHKALYTVRAYLNCDRYSVGLLDMTKEKEFFDIWPVLMGEQPP YSGPVTPDGREIIFYKVIDYILHGKEDIKVIPNPTADHWALASGLPTYVAESGFICNIMN AASEEMFKFQTEALDDSGWTIKNVLSLPIVNKKEEIVGVATFYNRKDGKPFDEHDEQLME ALTQFLGWSALNTDTYDKMNKLENRKDIAQDMVLYHVKCRDDEIQDILKTREYFDREPRD CEEEELLEILKKELPGPKKFEIYAFHFSDFDCTELQLVMCGIQMYYEVGVVKKFQVPQEV LVRFMYSVSKGYRRITYHNWRHGFNVGQTMFTLLTTGKLKQYYTDLEVMAMITAGFLHDI DHRGTNNLYQVKSQNPLAKLHGSSILERHHLEFGKFLLGEESLNIFQNLNRRQTEHVFHL IDIAIIATDLALYFKKRTMFQKIVDLSETYEERKKWIDFMSLETTRKEIVMAMMMTACDL SAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAAELPKLQCGFIDFVC TFVYKEFSRFHPEIKPMFDGILNNRMHWKERQEEYEAKLKAMEEAVKARQEAAAKNAANS NSTGGSGSKTCSIC >Danio rerio_PDE6Bb(ENSDARP_392) MAAVDKDVAEKFLDSNPMFAKQYYDSRFRAKVVSDLLSTTKQTAVDISSHHELSSMEECE IIFDMVRDMQENLHMERAVFNLMRHLSFMIRADRMSLFMYRQRNGIAELATRIFNVHKDA TLEECLVPPDSEIVYPLDTGIVGHVATAKKTVNVPDVTKDSHFSDFVDNLTEYETKNVLA TPIMNGKDMVAVMMAVNKIGAPHFTAQDEETLKKYLNFANLVLRVFHLSYLHNCETRRGQ VLLWSASKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKTKEFFDLWPVLMGEV PPYSGPKTPDGREVIFYKVIDYILHGKEDIKVIPNPPADHWALVSGLPTYVAENGLICNI MNAAQDEFFEFQKEPLDESGWMIKNVLSLPIVNKKEEIVGVATFYNRKDGKPFDEMDETL MESLTQFLGWSVLNTDTYDKMNKLENRKDIFQDMVMYHVKCRKDEIQNILNTREMYDKEP DECEEDELEDILNEVLPDSEESEIFEFHFCDFEFSELDLVKCGIKMYYELGVVDKFHIPR ETLVRFVYSVSKGYRKITYHNWRHGFNVGQTMFTLLMTGDLKRYYTDLEAMAMVTAGLCH DIDHRGTNNLYQMKSGNPLAKLHGSSILERHHLEFGKTLLRDEALNIYQNLNRRQHETVI HLMDIAIIATDLALYFKKRTMFQKIVDQSKTYDSWDSWTKYMMLETTRKEIVMAMMMTAC DLSAIAKPWEIQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAEELPKLQCGFIDF VCSFVYKEFSRFHVEITPMLERLLNNRKEWNALKEIHEAKVAKLDEAKKAKEEAHANSDH KQGNSVQPAAQSKTCVIS >Gasterosteusaculeatus_PDE6B(ENSGACP_22195) MVDAAAAEQFLDANPQFAKQYYDANFRPKVVSDLLDGNRKAAMDISAFHDLTAVEESEVL FDLMRDIQDNLQMEKSVFNLMKHLSFMMRADRMSLFMYRQRNGVAELATRLFNVNKDSQF DDCLVPPDSEIVYPLDMGIVGHVASTKKMVNIADVSESAHYSEFVDELTEYKTKSVLAIP IMNGKDMVAVMMALNKLDGPRFTAKDEETLNKYLNFGNLILRVFHLSYLHNCETRKGQVL LWSASKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKTKEFFDLWPVLMGEVPP YDGPKTPDGREIIFYKLIDYILHGKEDIKVIPNPPADHWVLVSGLPTYVAETGLICNIMN AGQDDFFKFQKIPLDDSGWTIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLME SLTQFLGWSVLNTDTYDKMNKLENRKDIFQDMVMYHVKCRKDEIQHVLNTRERWGKEPDE CEEEALQEILSEVLPDSKKCELFEFHFYDFHHTELELVKCGIKMYYELKVVDKFHIPRET LVRFIYSLSKGYRRITYHNWRHGFNVGQTMFTLLMTGDLKRYFTDLECMAMVTAGLCHDI DHRGTNNLYQMKSGNPLAKLHGSSILERHHLEFGKTLLRDEALNIYQNLNRRQHDTVIHL MDIAIIATDLALYFKKRTMFQKIVDQSKTYENWNEWTKYMMLETTRKEIVMAMMMTACDL SAIAKPWEIQSKVALSVAAEFWEQGDLERTVLEQVPIPMMDRTKADELPKMQCGFIDFVC AFVYKEFSRFHVEITPMLDRLMNNRKEWNALKEVHEAKMAAIEEAKKAKEEVAAGARQGR YMFPNPPPGAAPRSSSCSTP >Oryzias latipes_PDE6B(ENSORLP_12384) MGVGKEDVEKFLLENPAFAKTYFAKKLSPSSISKVSGLPEKQIDFSQFQELSQIEESRLM YDVIKDMQENVNMEKVVFKILKRISSLIHADRCSLFMYRQRNGIGELATRLFNVSMDSVL EDCVVQPDSEIVYPLDLGIVGNVALTKKNVNVKNVKESQHFSSFVDELTDYETRNVLAAP ILNGKDMVAVIMALNKTTGPHFTAEDEDLFLKYLKIASLNLKIFHLSYLHNCETRKGQLL LWSANKVFEELTDIERQFHKALYTVRAYLNCDRYSVGLLDMTKEKEFFDIWPVLMGEQAP YAGPVTPDGREVIFYKVIDYILHGKEDIKVIPNPTPDHWALQSGLPTYVAESGFICNIMN AGADETFKFQTEALDDSGWTIKNVLSLPIVNKKEEIVGVATFYNRKDGKPFDDHDEQLME ALTQFLGWSALNTDTYDKMNKLENRKDIAQDMVLYHVKCRNDEIQNVLNTREVYGCEPAE CEEEDLLDILKKELPPLIKKFEIYEFRFSDFNCTELDLVKCGIQMYYEVGVVKKFQIPQE VLVRFMYSVSKGYRKITYHNWRHGFNVGQTMFTLLTTGALKRYYTDLEVMAMITAGFLHD IDHRGTNNLYQVKSGNPLAKLHGSSILERHHLEFGKFLLSDESLNIYQNLNRRQVDHVIH LTDIAIIATDLALYFKKRTMFQKIVDLSKTYEEEKKWVDFMSLETTRKEIVMAMMMTACD LSAITKPWEVQSKVALSVAAEFWEQGDLERTVLEQQPIPMMDRNKAAELPKLQCGFIDFV CTFVYKEFSRFHPQIQPMLDGILNNRKEWNARKEEYEAKLKAIEEEMAAKEAAKAAKAAQ NNSSGGGSKTCSVC >Homo sapiens_PDE6A(ENSP_255266) MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEI IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV LEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIM NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW ECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGN QPGGNPSPGGATTSKSCCIQ >Macaca mulatta_PDE6A(ENSMMUP_6320) MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKVISDLLGAKEAAVDFSNYHSPSSVEESEI IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAV LEDCLVMPDQEIVFPLDMGVVGHVAHSKKIANVPNTEEDEHFCDFVDILTEYKTKNILAS PIMNGKDVVAIIMAVNKVDGSHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVP PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIM NAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM ESLAQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW ECEEEELAEILQAELPDAEKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE ALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACD LSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV CTFVYKEFSRFHKEITPMLDGITNNRKEWKALADEYDAKMKVQEEEKQKQQSAKPAAAGN QLGGNPSPGGATTSKSCCIQ >Mus musculus_PDE6A(ENSMUSP_25468) MGEVTAEEVEKFLDSNIGFAKQYYNFHYRGKVISDLLGAKEAAVDFSNYHDVNSVEESEI IFDLLRDVQENLQAEKCTFNVMKKLCFLLRADRMSLFMYRTRNGIAELATRLFNVHKDAV LEDCLVMPDSEIVFPLDMGVVGHVAHSKKIANVPNTEEDEHFCDFVDNLTEYQTKNILAS PIMNGKDVVAIIMAVNKIDEPHFTKRDEEILLKYLNFVNLIMKVFHLSYLHNCETRRGQI LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAP AYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPADHWALVSGLPTYVAQNGLICNIM NAPAEDFFEFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDMDETLM ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW ECEEEELAEILQGELPDAESYEINKFHFSDLPLTELELVKCGIQMYYELRVVDKFHIPQE ALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTACD LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYEAKMKALEEEKQKQQAAKQAASGN QPGGNPTPGGAPASKSCCIQ >Felis catus_PDE6A(ENSFCAP_3345) MGEVTAEEVEKFLDSNVSFAKQYYNLRYRAKVISDMLGAKEAAVDFSNYHSLNSVEESEI IFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRVRNGIGELATRLFNVHKDAV LDECLVVPDSEIVFPLDMGVVGHVAHSKKLANVLNTEEDEHFCDFVDILTEYQTKNILAS PIMNGKDVVAVLMAVNKLNEPHFTKRDEEILLKYLNFANLIMKVYHLSYLHNCETRRGQI LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAP PYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLICNIM NAPAEDFFEFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLM ESLAQFLGWSVLNPDTYESMNKLENRKDIFQDMVKYHVRCDNEEIQTILKTREVYGKEPW ECEEEELAEILQGELPDAEKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQE ALVRFMYSLSKGYRRITYHNWRHGFNGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDI DHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHM MDIAIIATDLALYFKKRTMFQKIVDQSKTYETEQEWTQYMMLEQTRKEIVMAMMMTACDL SAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVC TFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKALEEEKQKQQAGVQAAAGNQ PGGNPGSAGGAPASKSCCIQ >Homo sapiens_PDE6C(ENSP_360502) MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA AEDSGGGDDKKSKTCLML >Macaca mulatta_PDE6C(ENSMMUP_19304) MGEINQDAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT SNFDDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL ATPIVMGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSVILKLHHTSYMYNIESRRS QILMWSANKVFEELTDVERQFHKALYTVRTYLNCERYSIGLLDMTKEKEFYDEWPIKLGE VEPYKGPKTPDGREINFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPITEHGLIQCGIRLFFEINVVEKFKV PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEEGAEKA AEDSGGGDDKKSKTCLML >Mus musculus_PDE6C(ENSMUSP_25956) MGEISQEAVERYLEKNPCFAKEYFDKKLRVEALGVIFKNSHAGVQTGLSLPEMTQVEESA VCLELLQCMQDEAGSAEQMAHRALQRLAQLLQADCCSMFSCRARNGIPEVASRLLNVTPT SKFEDNLVAPDREVVFPLDIGIVGWVAHVKKALNVSDVKKNSHFSDFMDKQTGYVTRNLL AVPIVAGKEVLAVVMAVNKISAPEFSKQDEEVFSKYLSFVAVALRLQHTSYLYSVESRRS QILMWSANKVFEELTDVERQFHKALYTIRTYLNCDRYSIGLLDMTKEKEFYDEWPIKLGE VEPYKGPKTPDGREIIFYKIIDYILHGKEEINVIPSPPADHWTLVSGLPTYVAENGFICN MLNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEH ITETLTQFLGWSLLNTDTYERVNKLESRKDIAQEMVMNLTKATPDEISSILKFKEKLNVE VIEECEERQLLAILKEDLPDPRTADLYEFCFSDFPITEHELVKCGLRLFLEINVVEKFKV PVEVLTRWMYTVRKGYRPVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF CHDIDHRGTNNLYQMKSTSPLARLHGTSILERHHLEYSKTLLQDESLNIFQNLNKRQFET VIHLFEVAIIATDLALYFKKRTMFQKIVDTCEQMQSEEETIKYVTSDPTKKEVIMAMMMT ACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRSKKDELPKLQVGFI DFVCTFVYKEFSRFHGEITPMLNGLQNNRVEWKSLAEEYEAKVKVTEEEAGKQEEEASDG KAATDLGGSAEDKKSKTCLML >Felis catus_PDE6C(ENSFCAP_21685) MGEISQEAVEKYLEDNPQFAKEYFAKRLAEAPGPCGALSPADEWALCAELLRAVQEEARG AEPAVHGALQKLAQLLQADRCSLFACRARNGTPEVASRLFDVTPTSRFEDNLVGPDREVV FPLEIGIVGWVAHTKKAVNVPDVHKNSHFSDFMDKQTGYVTKNLLATPIMIGKEVLAVVM AVNKVNASEFSKEDEEVFSKYLSFVSVILKLHHTQYLYSVESRRSQILMWSANKVFEELT DVERQFHKALYTIRTYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREV IFYKIIDYILHGKEEIKVIPTPPADHWTLVSGLPTYVAENGFICNMLNAPADEYFTFQKG PVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEYDEHITETLTQFLGWSLLN TDTYDKMNKLENRKDIAQEMLMSQTKATPDEVKSILKIKEKLNIDVIEDCEEKQLVTILK EDLPDPQTVDLYEFRFSDFPITEHELIRCGLRLFFEINVVEKFKVPVEVLTRWMYTVRKG YRSITYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQM KSTSPLAKLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLA LYFKKRTMFQKIVDACEKMETEEEAVKYVTIDPTKKEVIMAMMMTACDLSAITKPWEVQS QVALLVANEFWEQGDLERTVLQQQPIPMMDRNKKDELPKLQVGFIDFVCTFVYKEFSRFH KEITPMLTGLQNNRVEWKSLADEYDAKMKVIEEETKKQEEGNMAAKEDSGGGSDDKKSKT CLML >Gallus gallus_PDE6C(ENSGALP_10688) MGEVNKDAVEKYLENNPQFAKEYFDRKMRAEVLGSIFQVSPGDVKEGVSFKDMSRLEECN ILFELLTEIQDEAGSMEKIVHKTLQRLSQLLAADRCSMFICRSRNGIPEVATRLLNVTPT SKFEENLVNPDKETVFPLDIGIAGWVAHTKKFFNIPDVKKNNHFSDYLDKKTGYTTVNMM AIPITQGKEVLAVVMALNKLNASEFSKEDEEVFKKYLNFISLVLRNHHTSYLYNIESRRS QMLLWSANKVFEELTDIERQFHKALYTIRMYLNCERYSVGLLDMTKEKEFYDEWPIRLGE AEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWCLISGLPTYVAENGFICN MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEEIVGVATFYNRKDGKPFDEYDEQ IIETLTQFLGWSVLNTDTYDKMNKLENRKDIAQEMLMYQTKATPTEVESILKYKEKLNVK SIEECDEKDLIRILKEELPDPKDLELYEFRFSDFPVTEHGLITCGIRLFFEINVVEKFKV PAEVLTRWMYTVRKGYRDITYHNWRHGFNVGQTMFTLLMTGRIKKYYTDLEAFAMVAAAF CHDIDHRGTNNLYQMKSAAPLAKLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET VLHLFEVAIIATDLALYFKKRTMFQKIVDAIEKMETEEEAIKYISIDPTKKEVIMAMMMT GCDLSAITKPWEVQSKVALMVANEFWEQGDLERTVLQQQPIPMMDRNKGDELPKLQVGFI DFVCTFVYKEFSRFHKEITPMFDGLQNNRVEWKTRADEYEEKMKVIEEQKKKEEEAAAKK AENAAGGGGGGEDGKSKTCIVL >Anolis carolinensis_PDE6C(ENSACAP_7118) MGGISKDDVEKYLENNPQFAKEYYDRKLRLEAVGSVFKVNPGDVKDGISFKEMTKLEESQ MLFELLLQIQEQDMEQDMEKIVHKVLQRLCQLLAADRCSMFVGRSRNGIPEMAARLLDVT PTSKYEDNLIPPEKEIVFTLDIGIVGWVAHTKKLFNIPDVKKNNHFSDSVDKQTGYTTIN MLATPIIHNKEVLAVIMVLNKKTEPEFSKEDEEVFKKYINFITIAIKHNHISNMYNLEMR KSQMLLWCGNKVFEELTDIERQFHKALYTIRIYLNCERYSVGLLDMTKEKEFYDEWPIKL GEAEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPSPPADHWCLASGLPTYVAENGFI CNMMNAPSDEYFNFQKEAFDETGWIVKNVLSLPIVNKKEEIVGVATFYNRKDGRPFDEYD EQITEMLTQFLGWSVLNTDTYDKMNKLENRKDIAQEMLMYQTKATPEEIQSILKWKEKLK VDSIEDCDEKQLLKILKEELPDPSNVELYEFRFSDFPVTEHELIKCGIRLFFEINVVEKF KVPAEVLTRWMYTVRKGYRDITYHNWRHGFNVGQTMFTLLMTGKIKKYYTDLEAFAMVSA AFCHDIDHRGTNNLYQMKSAAPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQF ETVLHLFEVAIIATDLALYFKKRTMFQKIVDAIEKMEKEEEAIRYISTDPTKKEVIMAMM MTGCDLSAITKPWEVQSKVAIMVANEFWEQGDLERNVLQQQPIPMMDRNKSEELPKLQVG FIDFVCTFVYKEFSRFHKEITPMFDGLNNNRVEWKSRADIYEEKMKAIEEEKKKQEEAEA KKGGAHYWGGGLPTGSPSTSFIIIR >Xenopus tropicalis_PDE6C(ENSXETP_8075) EMKKEDIEKYLENNPQFAKEYFDKKLRSETVGALFNSKELVLKDGVSFREMTKIEEADIL LELIKEIQDDCNMEKTVHKVLQRMAYLLQADCCSMFGFRSRNGIPELATRLFNVTKSSKF EDNLVAPESEIVFPLDIGIVGWVAHTKKSFNVPDVKKNTHFSDFADKQTGYTTKNLLAAP ILQGKEVLAVMMAVNKQNAAEFSKEDEEVFHKYLNFISVVLKYNHINYLHNIETRKSQVL LWTANKVFEELTDIERQFHKALYTVRVYLNCERYSVGLLDMTKEKEFYEEWPIKLGEVPP YKGPKTPDGREVIFYKIIDYILHGKEEIKVIPTPPEDHWSLVSGLPTYVAENGFICNMMN APADEFFKFQKEAVDETGWTIKNVLSLPIVNKKEEIVGVATFYNRKDAKPFDEYDEQITE ALTQILGWSVLNTDTYDKMNKLENRKDIAQEMLMYQLKCTPKELQSILKTKEKLNKEVEE CEETELLKILKEELPDPITAELYEFHFSDLPVSEHDLIKSGIRLFFEINAVDKFKVPVEV LTKWMYTVRKGYRDITYHNWRHGFNVGQTMFTLLMTGKLKKYYSDLEAFAMVAAAFCHDI DHRGTNNLYQMKSQAPLAKLHGSSILERHHLEFSKTLLQDESINIFQTLNKRQFENVIHL FEVAIIATDLALYFKKRTMFQKIVDTTEQMQSEDERIKYIICDPTKKEIIMAMMMTGCDL SAITKPWEVQSKVALMVANEFWEQGDLERTVLQQQPIPMMDRNKSDELPKLQVGFIDFVC TFVYKEFSRFHKEILPMYDGLQNNRVQWKSQADVYEEKMKILDEQKKKEEPNGGNPGQGG ELVKSKTCTLL >Danio rerio_PDE6C(ENSDARP_97279) MADKDSVEKYLENNPQFAKEYFDKKVRCEVIAAAFEEKLDIKDPASFKDVTQVQEAAILF DMIQDMHSQPVMEKAMHKVLQRICLLVNADRCSYFISRARNGIPELATCLFDVTPTSKYE ANLVNPQSEIVFPTDTGIVGQIVTTKKPANVPDVKQNPRFSDFVDKQTGYTTKNMMAAPL MQGKDPLGVVMAINKVGANEFSKEDEDVFSKYIIFATVIALQHYTNYMYNVESRRSQVLL WSASKVFEELTDIERQFHKALYTVRTYLQCERYSCGLLDMTKEKEFYDEWPIKLGDVEPY KGPKTPDGREIIFYKIIDYLLEGKEEIKVIPNPPADHWALVSGLPSYVAENGFICNMMNV AADEYFTFQKEAVDETGFVIKNVLSLPIVNKKEEIVGVATFFNRKDGKPFEEQDEQITEA LTQFLGWSVLNCDTYDKLNRMEWRKEIAEEMVMYQTKATPAEVQQILNTKEKFDQNPEDC DQKEMYKLLRANIPEAKDVDLLEFSFSDFPLTETDLIKCGIRCFFELGVVEKFKVPAEVL TRWMYTVRKGYRDITYHNWRHGFNVGQTMFCLLQTGKLRRYYTDLDAFAMVAAAFCHDID HRGTNNLYQTKSASPLAKLHGSSILERHHLQYSKNLMAEENVNIFQSLQKRQFETVQHLH DVCIIATDLALYFKKRTMFQKIVDATEPMTKEEEMVAHVANNPIRKEIIMAMMMTGCDLS AITKPWEVQSKVALMVAAEFWEQGDLERTVLDQQPIPMMDRNKSDELPKMQCGFIDFVCS FVYKEFSRFHKEITPMFDGLNNNRVHWKELADIYQAKIDAIANEKKRLEEEQAKKGGEEG GEGGKSKTCTIF >Takifugu rubripes_PDE6C(ENSTRUP_28323) FNMADKDTVEKFLDNNPEFAKVYYEKKVKADVITAAFNNQVQVKDPASYKDLSTIQEAEF IFELIKEIQSSNPLEKILHKILQRIALLIQADRCSYFGCRARNGTPELSTILFDVTHNSP LEKNIVNPNVEIVFPTDMGVVGWTAHSKKPQNIPDVKKDSHFSDFVDKQTKYTTKCVITA PVMSGKEPIGVIMALNKQGAEDFSKSDQELFNKYVNFAAVVVMQAHTSYMWDVESRKSQV LLWAASKVFEELTDIERQFHKALYTVRTYIKCERYSVGLLDMTKDKEFFDEWAIKLGDQE PYKGPKTPDGREISFYKIIDYLLEDKEEIKVIPGPPADHWALVSGLPSYVAENGMICNMM NAAADDYFTFQKEAVDESGWKIKNVLALPIVNKKEEIVGVATFFNRKDGKPFDENDEQII ESLTQFLGWATLNSDTYDKLNRTEWRKEVAQEMLMYQTKASLSDVQTILNTQEKFGSDPE DCDQKEMYKLLKSNIPDAKTVDLHEFHFSDFPLSEFELIKCGIRCFFELGVVEKFKVQAE TLTRWMYTVRKGYRDITYHNWRHGFNVGQTMFTLLLTGKLKKYYSDLDAFAMVAAGFCHD IDHRGTNNLYQTKSLSPLAKLHSSSVMERHHLEYSKTLMEDENLNIFQNLQKRQFETVQH LFEVCIIATDLALYFKKRTMFQKLVESMQAMPEEKERISYVSNNPTRKEIIMAMMMTACD LSAITKPWEVQSKVALMVAAEFWEQGDLERTVLEQQPIPMMDRNHADELPKMQCGFIDFV CSFVYKEFAHFHSEIQPMFDGLNNNRCEWKALADVHEAKIKAIEDGKKKPEEPDQSKPSA TDVTSLITVVNIPSLLFL >Oryzias latipes_PDE6C(ENSORLP_6480) VKMADKDSVEKYLDNNPQVAKDYFDKKIRAEALTAAFSQTVDVKDTASFKDVNAIQESAI IFELVKELQKVENMEKSLHKVLQRVALILQADRVGFFQCRSRNGIPELSSSLFDVTPTSK FESNLVNPQAEIVFPLDMGIVGHTANSKKPQNVPDVTKNPKFSDFVDKQTGYKTKCMLTF PLMAEKECLGVVMMLNKIGADAFTAEDEKLFHKYMTFAQVITLQHYTTYMFNVESRRSQV LLWSASKVFEELTDIERQFHKALYTVRTYLQCERYSVGLLDMTKEKEFYDEWPVKLGDVE PYKGPKTPDGREIIFYKIIDYLLEAKEEIKVIPGPPADHWALISGLPTYVAENGFICNMM NVAADDYFTFQKEAVDETGFVIKNVLSLPIVNKKEEIVGIATFFNRKDGKPFDEHDEQIT EALTQFLGWSVLNCDTYDRLNRMEYRKDIAQEMLMYQSKCTPAELQSILNTKEKFDAEPE DCDQKEMYKLLKSNIPPADNVDGESLYSFAFSDFPVSEFGLIKAGIRMFFELGVVEKFKV PAETLVRWMYTVRKGYRAITYHNWRHGFNVGHTMFCLLQTGKLRKYYSDLDAFAMVAAAF CHDIDHRGTNNLYQTKSASPLAKLHGSSIMERHHLEYSKTLMGEECLNIFCNLQKRQFEN VQHLFDVCIIATDLALYFKKRTMFQNIVNATEPMTDEKEATAYISNNSIRKEIVMAMMMT GCDLSAITKPWEVQSKVALMVAAEFWEQGDLERSVLDQQPIPMMDRNCAEQLPKMQCGFI DFVCSFVYKEFSRFHKEIQPMFDGLNNNRAHWNELAEVYNAKMKAIEDEKKRLEEEEAKK GKEQKHGAGGGEVGKSKTCTIS >Homo sapiens_PDE11A(ENSP_286063) MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT NRSKWEELHQKRLLASTASSSPASVMVAKEDRN >Macaca mulatta_PDE11A(ENSMMUP_2693) MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS LAHSTCKGGSSIGGGIGPNGSAHSQPLPGGGDCGGVPLSPSWASGSRGDGNLQRRASQKE LRKSFARSKAIHVNRTYDEQATSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV NLPQYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL FLVERAAAGKKSLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC ERCSVLLLEDIESPVVKFTKSFELLSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI PLVSELAINDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM VLYHNWRHAFNVCQLMFAMLTTAGFQEILTEMEILAVIVGCLCHDLDHRGTNNAFQAKSG SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY FERRTEFFELVSKGEYDWNIKNHRDVFRSMLMTACDLGAVTKPWEISRQASELVTSEFFE QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAA NRSKWEELHQKRLLASTASSSPASVMVATEDRN >Mus musculus_PDE11A(ENSMUSP_97572) MAASRLDFGEVETFLDRHPELFEDYLMRKGKQELVDKWLQRHTSGQGASSLRPALAGASS LAQSNAKGSPGIGGGAGPQGSAHSHPTPGGGESAGVPLSPSWASGSRGDGSLQRRASQKE LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV NLPQYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP DAYQDRRFNDEIDKLTGYKTKSLLCMPIRNSDGEIIGVAQAINKVPEGAPFTEDDEKVMQ MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESVEKSSYSDWLINNSIAELVA STGLPVNVSDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM VLYHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSD SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY FERRTEFFELVRKGDYDWSITSHRDVFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE QGDRERSELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNAKLKPMLDSVAA NRRKWEELHQKRLQVSAASPDPASPMVAGEDRL >Felis catus_PDE11A(ENSFCAP_17362) MTASHLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSESQGAVGPRPAVASTNS LAHSGGRRSGSVGGGPGPNSSANSQPTLGGGDCGGVPLSPSWASGSGGDGSLQRRASQKE LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV NLPQYPPTAMDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL FLVEGAAAGKKSLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSVAELVA STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKAFD DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDNQVLSYHATCSKAEVDKFKAA NIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNY RMVLYHNWRHAFNVCQLMFAMLTTAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAK SGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLT LYFERRTEFFELVSKGEYDWNIKNHRDVFRSMLMTACDLGAVTKPWEISRQVAELVTSEF FEQGDRERSELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSV AANRSKWEELHQKRLLVPAASPSSASVVAAGEDRN >Gallus gallus_PDE11A(ENSGALP_14983) MAADGGLDVAAVESFLDRHPELVERWLKRRNSLPKAPAGGPSEERRVGGGWGGAGGPGAG GLQRRASQKELRKSFARSKAIHVNLTYDEHVHARAQEPLSSVRRRALLRKASSLPPTTAH ILSALLESRVSLPQYPPPALDYKRYLKEHNERQFFLELVKDISNDLDLTSLSYKILIFVC LMVDADRGSLFLVEGAAAGKKSLVSKFFDVHAGTPLLPCGSTENSSEVQVPWGKGIIGYV AEHGETVNIPDAYQDRRFNDEIDKLTGYKTNHFCVCPKNSDGEIIGVAQAINKTPGGAPF LMTMKKKVMQMYLPFCGIAISNAQLFAASRKEYDRSRALLEVVNDLFEEQTDLEKIVKKI MHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELLSPKCSADTENSFKEGVEKSPSYSDW LINNSIAELVASTGLPVNISDAYQDPRFDAEADQIFGFHIRSVLCVPIWNSSHQIIGVAQ VLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSK AEVDKFKAANIPLVSELGIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCR WLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQEILTEIEILALIVGCLCHDLDHR GTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKDYSDLMQLLK QSILATDLTLYFERRTEFFELVGKGGYDWNVKNHREIFRSMLMTACDLGAVTKPWEISRQ AAELVTSEFFEQGDRERSELKLIPSAIFDRNRKDELPRLQLEWIDSICMPLYECLVKLNV KLKPMLDSVAKNRGKWEELHHQRLPSQAASSSSFPSTFTMSLKDIN >Anolis carolinensis_PDE11A(ENSACAP_11888) GSSGAVPLAWAEESGALHRRASQKELRRSFARSKAIPVNRTYEEPGRARAQEPSLRSARR RALLRKASSLPPTTAHILSALLESRVNPPACPPTALDYKRQLKQHNERQFFLELVKDISN ELDLRALSYKILIFVCLMVDADRGSLFLVEAGAAGKKSLVSKVFDVHAGTPLLPCCCCGG AAEDANEAQVPWGKGIIGYVAEHGQTVNLPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRS SDGEIIGVAQAINKTPGGAPFTDDDEKVMEMYLPFCGIAISNAQLFAASRKEYDRSRALL EVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCS ADTENSFKDSLEKTSSSYSDWLVNNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFH IRSVLCVPIWNSSHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVK KSWAKQSVALDVLSYHATCSKAEVDKFKAANLPLVTELGIDDIHFDDFSLDMDAMITAAL RMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQEI LTEIEILALIVGCLCHDLDHRGTNNAFQAKIGSALAQLYGTSATLEHHHFNHAVMIIQSE GHNIFANLSSKDYSDLMQLLKKSILATDLTLYFEKRAEFFELVNKGDYNWNIKSQREIFR SMLMTACDLGAATKPWEISRQVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPRL QLEWIDSICMPLYQVLVKVNGKLKPMLDSVVVNRRNWEELHQQRLLSKAAATEPTKSSSS SSSSSQSAKCPKDIN >Xenopus tropicalis_PDE11A(ENSXETP_18528) MSEPALDFSKVERYLDNHPELFEDYLIRKGKHQMVERWMKRNQLAKTPSSSSADDKSKDC WSNRGDGLQRRASQKELRKSFARSKAINVNRTYDEHVNSRAQEPLTSMRRRALLRKASSL PPTTAHILSALLESRVNIPQYPSTAIDYIYYLKEHNERAFFLELVKDISNELNLTSLCYK ILIFVCIMVDADRCSLFLVEGTANKKSLVSKFFDVHAGTTLLPSCSTENSNEVQVPWGKG IIGYVAEHGETVNIPDAYQDRRFSDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKT PGGAPFIEDDEKVMQMYLPFCGIAISNAQLFAASRKEYDRSRALLEVVNDLFEEQTDLEK VVKKIMHRAQNLLKCERCSVLLLEDIESPVVKFTKSFELLSPKCSADTENSFKDSVEKSS YSDWLVNNSIAELVASTGLPVNISDAYQDPRFDVEADQFSGFHIRSVLCVPIWNSSHQII EGVAQVLNRIDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYH ATCSKAEVDKFKAANIPLVSELSIADIHFDDFCLDVDAMISAALRMFMELGMVQKFKIDY ETLCRWLLTIRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQEVLSDTETLALIVGCLCH DLDHRGTNNAFQAKSGSALSQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSQEYSDL MQLLKQSILATDITLHFERRNEFFELVNKGDYNWNVKSHRVIFRSMLMTACDLGAATKPW EISRQVAELVTSEFFEQGDRERLELKMTPSAIFDRNRKDELPRLQLEWIDNICFPLYESL VKINGKLKPMLDSVTTNRGKWEELHRKQGNSSSTSYPTPASSPQPAIECLLKT >Danio rerio_PDE11A(ENSDARP_87859) MAGANMVFSDVETFLDEHPELLEDYLNRKGKASMVEKWMKSHPKTPEKAASACAKDSWAS RGDGLQRRASQKELRKTFARSKAINANRTYDEHVNSRAQEPLTSMRRRALLRKASSLPPT TAHILSALLESRVNIPQYPSTAVDYKYYLKEHNEREFFLELVKDISNDLDLTSLSYKILV FVCIMVDADRCSLFLVEGPTNKKTLVSKFFDVHAGTTVLPSLSNSDEVQVPWGKGIIGYV AEHGETVNIPDAYQDHRFSDEIDKLTGYKTKSLLCMPIHNSDGEVIGVAQAINKSPNGAL FTQDDEKVLLAQCFMPFCGIAISNAQLFAASRKEYDRIKSTLHLCTKAGRLHNVFLEIWS DFMHRAQTLLSCWCYLLQVVKFTKSFELLSPKCSADMENSFKDSMDKSSYSDWLINNSIA ELVASTGLPVNISDAYQDPRFDAEADQFSGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDG KPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKTEVDKFK AANIPLVCELGIDKLSFDDFSLDVDAMVTAALRMFMELGMVQKFKIDYETLCRWLLTVRK NYRMVLYHNWRHAFNVCQCMFSMLTTAGFQETLTEMETLALIVGCICHDLDHRGTNNAFQ AKTGSALSLLYGTSATLEHHHFNHAVMILQSEGHNIFSNLSSHEYGELMQLLKQSILATD LTLYFQNRNSFFELVNKGEYNWNVKEHREMCRSMLMTACDLGAVTKPWEISHKVAELVTS EFFEQGDRERSELKLTPSTQTKTNRKTGKGRLFSKFKWICAPLYETFAKLNPKLQPMMDL IKANRAKWEELHHRHQRISQEASIPASPDHAEVSSSCS >Takifugu rubripes_PDE11Aa(ENSTRUP_44767) MAVPKMVFSDVESFLDSHPELFEDYLNRKGSSSMVEKWLKNHQAGKSEAEPKEEKSSVCK DSWASKCDGLQRRASQKELRKTFARSKAINVNRTYDEHVNSRAQEPLTSMRRRALLRKAS SLPPTTAHILSALLESRVNIPQYPSTAVDFKYYLKEHNEREFFLELVKDISNDLDLTSLS YKILVFVCIMVDADRCSLFLVEGTGNKKTLVSKFFDVHAGTTVLPSMNSGEVQVPWGKGI IGYVAEHGETVNIPDAYQDRRFSDEIDKLTGYKTKSLLCMPIQNSDGEIIGVAQAINKSS SGELFTEDDEKVLQMYLPFCGIAISNAQLFAASRKEYDRSRALLEVVNDLFEEQTDLEKI VRKIMHRAQTLLKCERCSVQLLEDIESPVVKFTKSFELLSPKCSADAESSFKDSMEKSSY SDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQFSDFHIRSVLCVPIWNSNHQIIG VAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHAT CSKTEVDKFKAANIPLVCELGIDKLSFDDFSLDVDAMITAALRMFIELGMVQKFKIDYET LCRWLLTVRKNYRMVLYHNWRHAFNVCQCMFAMLTTQTAGFQETLTDVEILALIVGCVCH DLDHRGTNNAFQAKTGSALSLLYGTSATLEHHHFNHAVMILQSEGHNIFCNLSSTEYSDL MQLLKQSILATDLTLYFENRNSFFELVSIGEYNWNVKTHRDMCRSMMMTACDLGAVTKPW DISRKVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPGLQLEWIDGICAPLYETL VKLNPKLQPMVDMINANRVKWEELDKKRQHDHGASVPASPCSAAEGSETGGVPCCSNNTP PTHVS >Takifugu rubripes_PDE11Ab(ENSTRUP_38601) FTMTTFDFSDVEAFLDCHPDLFEEYLVRKAKCDQVGRWLKEHQPSKVSAAEERRGAPRDQ TWSTNPEALRRRSSHMELRRNFARSKATTAHRTYDEHVNLSEYEYESSMRRRALLRKASS LPPTTAHILSALLESRVNVPQYASSAIDYKYRLKETNEREFFLELVKDISNDLDLTNLSY KILINVCILVDADRCSLFLVEGPAHKRTLVSKFFDVHSGTTVRPSSSTLNSNEVQVPWGK GIIGYVAEHGETVNIPNAYEDHRFSDEIDKLTGYKTQSILCLAICNSDGEVIGVVQAINK NPMGTPFTEDDEKVLQMYLPFCGISISNAKLFSESRKEYERSRALLEVVNDLFEEQTDLE KIVRKIMQRALTLLQCERCSVLLLEDIDSPVVKFSKTFELMSPLCTMDHDISFLGRISME KLSCSDWLINNSIAELVASTGLPVNISDVCQDPRFDAEADQASGFHIRSVLCVPIWNRTH QIIGVAQILNRLDRKTFNDADQRLFEAFVIFCGLGINNTMMYNQVKKTWAKQSVALDMLS YHATCSKVEVDRLKAAKIPLSSELGIDEFHFNDFSLDNDAMITASLRMFLELGVVQKFKI DYEVLCRWLLTVRKNYRTVAYHNWRHAFNVSQCMFIMITTASFQDLLSDAEILALMVGCL CHDLDHRGTNNAFQAKTGSALALLYGTSATLEHHHFNHAVMILQSEGHNIFANLCSKEYS NMMQLLKQAILSTDLTLHFERRTKFFESVLSGEFKWTDEGHREVFRSMLMTACDLGAVTR PWKISKQVAELVTSEFFEQGDRERAELKLTPAPIFDRNRKDELPDLQLEWIDGICKPLYK TLLKLNRKLQPMVDEMDANRNKWQDLCLSETRRASLTNQSADLSQNPESCENRE >Homo sapiens_PDE10A(ENSP_438284) MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV AQKAAASED >Macaca mulatta_PDE10A(ENSMMUP_31087) AAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVS AETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYEL SSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTISAYVAKSR KTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSH QEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAK NLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGE VLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDEN NFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTAEEWQGLMRFTLPVRLC KEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKH AVTVAHCMYAILQNNHALFTDLERKGLLIACLCHDLDHRGFSNTYLQKFDHPLAALYSTS TMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMY QTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQ PIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGE ETATWISSPSVAQKTAASED >Mus musculus_PDE10A(ENSMUSP_86485) MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK TNKAKDEPSPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIRIATKAD GFALYFLGECNNSLCVFIPPGMKEGQPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGD ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF QVDHKNKELYSDLFDIGEEKEGKPIFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMRFNLPARICRDIELFHFDIG PFENMWPGIFVYMIHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI LQNNNGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQS HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKRD EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLNQWEKVIRGEETAMWISGPGP APSKSTPEKLNVKVED >Felis catus_PDE10A(ENSFCAP_11932) MATLYGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKPEDESAPKEVSRYQ DTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCVF TPPGIKEGKPRLIPAGPIAQGTTISAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQS VLCLPIVTAIGDLIGILELYRHWGKEAFCMSHQEVATANLAWASVAIHQVQVCRGLAKQT ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIG EEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNI LCMPIVSRGSVIGVVQMVNKLSGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECI YRVTMEKLSYHSICTAEEWQGLMHFNLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRS CGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHGLFTDLERKGLL IACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSS EYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCS VTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPC YTTLTQIFPPTEPLLQACRNNLSQWEKVIRGEESAVWVSSQPGAHEPSEKLPVKMGD >Gallus gallus_PDE10A(ENSGALP_18787) MEDGSNSASCFRRFTDCFLNTRRRGSWMQQTTRSYVEGLTDEKVKAYLSLHPQVLDEFVS ESVSAETVEKWLKRKNNRQEDESTPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLL LYELSSIIKIATKADGFALYFLGECNNSLCVFTPPGAKEGQPRLIPAGPIAHGTTVSAYV ARSRKTLLVEDILGDERFPKGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAF HLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIM IYAKNLVNADRCALFQVDHKNKELYSDLFDIGEENDGKPVFKKTKEIRFSIEKGIAGQVA RTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSK TDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSVCTAEEWQNLMHCTLP PHIYKEIELYHFDISPHEDVWPAIFVYMVHQSCGTACFELEKLCRFTMSVKKNYRRVPYH NWKHAVTVAHCMYAILQNNQGLFTDLERKGLLVACLCHDLDHRGYSNSYLQKFDHPLAAL YSTSTMEQHHFSQTVSILQLEGHNVFSNLSSSEYEQVLEIIRKAIIATDLALYFGNRKQL EELHQAGALNLKNQAHRDRVIGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKK TGIQPIPMMDRDKKDEVPQGQIGFYNAVAIPCYTTLAQIFPPTGPLLRACRDNLNQWEKV TRGEEASIWITSQSVAPGTSDSLPVKTDD >Anolis carolinensis_PDE10A(ENSACAP_3347) MNCSQKIFFHWGKSGIRNKLEGLTDEKVKAYLSLHPQVLDEFVSESVSSETVEKWLRRKN HIDEDVSTPKHVNRYQNSDMQGVVYELNSYIEQRLDIGVNNQLLLYELSGVIRMAINADG FALYFLADCNNSLCVFTPPGIKDGQPQLIPVGPIQQGTTVSAYVAKSRETLLVEDILGDE RFPKGTGLESGTRIKSVLCLPIVNAIGDLIGILELYRYWGNETFHLSHQEVATANLAWAS VAIHQVEVSRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQ VDEKNNELYSDLFDIGEEQEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPR FNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKLSGSAFSKTDENNFKMFAVFCALA LHCANMYHRIRHSECIYRVTMEKLSYHSVCTEEEWQNLMDCKLPPHLCKEIELYHFDISP YEDFWPAIFIHMIHQCCGIGWRISREDTQDKEECSAMLSALSLYVESDVVEEGFDLEKLC RFTMSVKKNYRRVPYHNWKHAITVVHCMYAILQNNHTVFTDLERRGLLVACLCHDLDHRG YSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSNLSSSDYEQVLEIIRKA IIATDLALYFGNRKQLEELHQGRTLNFKNQAHRDRVIGLMMTACDLCSVTKLWHVTRLTA SDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQIGFYNAVALPCYTTLAQILPPTA PLLRACKENLKQWEKVIRGEEAYGWIPTQSNSTGSDSLPVKIDD >Danio rerio_PDE10A(ENSDARP_27138) MEDGPPSTSCFRRFTDCFLGSSLTDEKVKAYLSLHPQMLDEFVLESVSSETVDRWLKRKS STQPADDSSAKEVSRYQDTNMQSVVYELNSYMEQRLDTGGDNKLLLYELCNIIKTATKAD GFALYFLGECNNSLCLFTPTGAKEGLPGLIPSGPITFGTTIAAHVAKTRKTLLVEDIMGD ERFPHGTGQDSGIRVHSVLCLPILTAIGDLIAILELHRHLGREPFNLSHQEVATANLAWA SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF QVDHNNKELYSDLFDIGEENEGKPVFRKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP RFNREVDLYTGYTTRNILCMPIVSRGTVIGVVQMVNKLGGSAFTKTDENNFKMFAVFCAL ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWKTLTQLTLPSAIYKEIELFHFDIA PFEELWPAIFVYMVHNSCGKTSFELEKLCRFTMSVRKNYRRVPYHNWKHAVTVAHCMYAI LQKTTGIFTELERKGLLIACLCHDLDHRGYSNSYLQKFDHPLAALYSTSTMEQHHFSQTV SILQEGHNIFSNLTSGEYEQVLEIIRKAIIATDLALYFGNRKQLAELLSTGALDLNNRAH RDRVIGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKIGMQPISMMDRDKKDE VPQGQVGFYNAVAIPCYTTLSELFPPSVPLLEACRENLSQWERIVQGEDVSAWSSTEEAE VSETSDSDQLKWTTESVAPFPQHHPQPARDTGLPVDSPTSCRDGRKCRGQADEDTFRKKI NKT >Takifugu rubripes_PDE10A(ENSTRUP_29340) MEDGPSSTSCFRRLTDCFLGASLTDEKVKAYLSLHPQMLDDFVLESVSTETLDRWLKKKT SSGPADDASAKEVSRQYQDTNMQGVVYELNSYMEQRLDTGGDNKLLLYELCNIIKTATKA DGFALYFLGESNNSLCLFTPTGAKDGPPSLIPSGPIAFGTTIAAHVAKTRRTLLVEDIAG DERFPDGTGQDSGIHVHSVLCLPILTAIGDIIAVLELHRHRGKEPFNLSHQEVATANLAW ASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCAL FQVDHNNKELYSDLFDIGEENEGRPVFRKTKEIRFSIEKGIAGQVARTGEVLNIPDAYAD PRFNREVDLKTGYTTRNILCMPIVSRGTVIGVVQMVNKLSGCAFTKTDENNFKMFAVFCA LALHCANMYHRIRQSECIYRVTMEKLSYHSICTSEEWKTLTQLNLPAPIYKEIEMFHFDI NPFEEIWPAVFIYMVHNSCGKSSFELEKLCRFTMSVRKNYRRVPYHNWKHAVTVAHCMYA ILQKTSGMFTELEKKGLLIACLCHDLDHRGYSNTYLQKFDHPLAALYSTSTMEQHHFSQT VSILQLEGHNIFSNLNSSEYEQVLEIIRKAIIATDLALYFNNHQQLTELLSSEALDLNNY SHRDRVIGLMMTACDLCSVTKKWQITRLTANDIYAEFWAEGDEMKKIGLQPIPMMDRDKK DEVPQGQVGFYNSVAIPCYTTLSKLFPPSNPLLKACKENLSMWEKIACGEVEDVVTSPPY DSGPVKGVEPTSRVAG >Homo sapiens_PDE2A(ENSP_334910) MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE >Macaca mulatta_PDE2A(ENSMMUP_19727) QDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKV WFTDQDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQPPRPIQKGNAHVFLDCLMTWRP AVAQDPRHCPQALYCSIWALQQHQLELVFDGGVVDDESYEIRIPADQGIAGHVATTGQIL NIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDL ATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAI DSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYH NWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLA ALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRI FKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDL EKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWT KVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE >Mus musculus_PDE2A(ENSMUSP_127521) MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAG LRQAARDALSAVLPKVETVYTYLLDGESRLVCEDPPHELPQEGKIREAVISQKRLSCNGL GPSDLLGKPLARLVAPLAPDMQVLVIPLLDKETGSVAAVILVHCGQLSDSEEQSLQVVEK HALVALRRVQALQQRRPEAVQNTSVDASEDQKDEKGYTDHDRKILQLCGELFDLDATSLQ LKVLQYLQQETQATHCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTMGRLGQVVEDKQC IQLKDLTSDDVQQLQNMLGCELQAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDEHV IQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLS NAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHP LFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCG ISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTY TPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVS HFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSV MERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAE VGYDRNNRQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPM EMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIR GLPSNNSLDFLDEEYEVPDLDGTRAPVNGCCSLE >Felis catus_PDE2A(ENSFCAP_12233) MGQACGHSILCRSQQYPAARPAEPVLSRGWGLXXPPPPPQPCADSLQDALLSLGSVIHIA GFQRAVKEALSAVLPKVETVYTYLLDGESRLVCEDPPHELPQEGKVREAVISRKRLGCNG LGPSDLPGKPLARLMAPLAPDTQVLVMPLVDKEAGAVAAVILVHCGQLSDSEEWSLQAVE KHALVALRRVQALQPRGPGAASAAVRNPPAGVAGDQKGGVAHTDQDQKILQLCGELYDLD ASSLQLKVLQYLQQETQASRCCLLLVSEDNLQLSCKVIGDKVLEEETSFPLTTGRLGQVV EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLGGDLFTD QDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL QKMAEVGYDRTNKQHHSLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH KFTIRGLPSNNSLDFLDEEYEVPQLDGTGAPVNGCFSLDAE >Anolis carolinensis_PDE2A(ENSACAP_2806) FQVSDDEYTKLLNENILPVSNIDTDFAKFTYTPRSLPDDDTSMAILSMLQDMNFISSYKI DRQTLVRFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELVNYLEDIEIFALFISCM CHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTQGCNIFDHFSRKDY QRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDPKNKQHHSLLICLLMTSCDLSDQTK GWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLL QDLFPRSAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYDLQTMGEDSEDSIR MNGCLEDGHLEEGEELE >Takifugu rubripes_PDE2A(ENSTRUP_23076) QDALLRLAAVVDVHSLRAAFRDSVQDLLPHTECVCVYMLDGESRLICDEPPHELPKEGKI RSIVNQLNRRQCNGLPLSELPEKYRACLAAPLPAHRRAIIIPILDQKQSEAIAVLLVGCN SLSDQDEVHLNTLEKHTLVAHKRMNKITLPASSLPPQASSQPFFRTVHDALLHLDISGHD YSQLDRDILQLCGELFDLDAASLQLKVINYLQQQTQSECCCLLLVSEDNHQLFCQVVGDK VLEEEISFPLTFGHFGQVVQKKQSITLQDITAEECRQMSTMLGCKIMSMLCVPVASRATG QVVALACAFNKQGGQRHTEADEHAIQHCFCYTSTVLTSTLAFQKEQKLKVECQALLQVAK NLFTHLDDVSVLLQEIIVEARNLSGAEICSVFLLDRLSHELVAKVFDGGVVSDEEKEFRI PADQGIAGHVATTGQILNIKDAYSHPLFYRGVDDSTGFRTRNILCFPIKDETNEVIGVAE LVNKMNGPWFNRFDEDLATAFSIYCGISIAHSLLYKRVHEAQFRSHLANEMMMYHMKVSG EEVSKLLVSGIEPIKEIDPCFAEFTYTPRSLSDDSTPMCVLSMFEDMGFINTYKIDLHTL ARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLGLSRYLQDIEILALFVSCMCHDLD HRGTNNSFQVASQSVLAALYSSEGSVMERHHFAQAIAILNTVGCNIFEKFSRKDYQRMLD LIRDIILATDLAHHLRIFKDLQKMADDGYNPKSQTHRSMLLCLLMTSCDLSDQTKGWKTT RKIAELIYKEFFSQGDLEKAMGNRPSEMMDREKAYIPELQISFMEHIAMPIYKLLSELFP GAAELYERVAANREQWTKVSHKFTIRGLPSNNSLDFLDQEYELLQSEGALTSDDQCLNGC LDDAE >Homo sapiens_PDE3B(ENSP_282096) MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELR PPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLS PLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGD AGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSL PSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSL GETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEAR NMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKG DRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGP FNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDT ADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSG KSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLD LILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRIN HGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQ AVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDN DTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEE KCKADGNKLQVENSSLPQADEIQVIEEADEEE >Macaca mulatta_PDE3B(ENSMMUP_1027) MRRDERDAKAMRSLQQPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELR PPPASPQQPRRGSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLS PLFSIACAFFFLTCFLTRTKRGPGPGRSGGSWWLLALPACCYLGDFLVWQWWSWPWGDGD AGSPATHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCLLVLLLASFVWWVSFTSLGSL PSALRPLLSGLVGGAGCLLALALDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSL GETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLAVLNEAR NMVSDLLIDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKG DRKLNKGLNRNSSPTPQLRRSSGTSGLLPVEQSSRWERNNGKRPHQEFGISSQGCYLNGP FNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSPNYGPMAAGSLTNRSPIEFPDT ADFLNKPSIILQRSLGNAPNTPDFYQHLRNSDSNLCNNCGHQILKYVSTSESDSTDCCSG KSGEEENIFSKESFKLMETQQEEKTEKKDSRKLFQEGDNWLTEESQNEQQTNIEQEVSLD LILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQF MNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRIN RGRIAYISSKSCSIPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQ AVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFD FLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFY EQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIEAEEDN DTESGDDEDGEELDTDDEEMENNLNPKPPRRKSRRQIFCQLMHHLTENHKIWKEIIEEEE KCKADGNKLQVENSSLPQADEIQVIEEADEEEERQFE >Mus musculus_PDE3B(ENSMUSP_32909) MRKDERERDAPAMRSPPPPPASAASPPESLRNGYVKSCVSPLRQDPPRSFFFHLCRFCNV EPPAASLRAGARLSLGVLAAFVLAALLGARPERWAAAAAGLRTLLSACSLSLSPLFSIAC AFFFLTCFLTRAQRGPGRGAGSWWLLALPACCYLGDFAAWQWWSWLRGEPAAAGRLCLVL SCVGLLTLAPRVRLRHGVLVLLFAGLVWWVSFSGLGALPPALRPLLSCLVGGAGCLLALG LDHFFHVRGASPPPRSASTAEEKVPVIRPRRRSSCVSLGESAAGYYGSGKMFRRPSLPCI SREQMILWDWDLKQWCKPHYQNSGGGNGVDLSVLNEARNMVSDLLIDPSLPPQVISSLRS ISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSGRTSFPTPQLRRS SGASSLLTNEHCSRWDRSSGKRSYQELSVSSHGCHLNGPFSSNLFTIPKQRSSSVSLTHH AGLRRAGALPSHSLLNSSSHVPVSAGSLTNRSPIGFPDTTDFLTKPNIILHRSLGSVSSA ADFHQYLRNSDSNLCSSCGHQILKYVSTCEPDGTDHPSEKSGEEDSSVFSKEPLNIVETQ EEETMKKACRELFLEGDSHLMEEAQQPNIDQEVSLDPMLVEDYDSLIEKMNNWNFQIFEL VEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATD VLHAVWYLTTRPIPGLPQIHNNHETETKADSDGRLGSGQIAYISSKSCCIPDMSYGCLSS NIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLS RPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSEND RLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEATLGLPISPFMDRSSPQL AKLQESFITHIVGPLCNSYDAAGLLPGQWIETEEGDDTESDDDDDDDDGGGEELDSDDEE TEDNLNPKPQRRKGRRRIFCQLMHHLTENHKIWKEIIEEEEEKCKAEGNKLQVDNASLPQ ADEIQVIEEADEEEEQMFE >Felis catus_PDE3B(ENSFCAP_19173) MILWDWDLKQWYKPHYQNSGGGSGVDLSVLNEARNMVSDLLIDPTLPPQVISSLRSISSL MGAFSGSCRPRINPLTPFPGFYPCSEVEDPAEKGDRKLHKGLHSRNSLPTPQLRRSPGTS GLPPIEQSSSRWERSNGKRPHQEFGISSQGSYLNGPLSSNLLTMPKQRSSSVSLTHHIGL RRAGAFPSLSPVNSPSHGPVSAGSLMNRSPVEFPATASSLTKPSVILHRSLGSAPNSPDF YQHVRNSDSSLCNSCGHQILKYVSTSESESGIDCHSGKSGDEDNTVSSKQSFSLTEVQHE VETENTDCRKLFLEGDTHLTEEAQNEQQPNIEQEASLDLILIEDYDSLIEKMSNWNFQIF EVVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTLQFMNYFRALENGYRDIPYHNRIHA TDVLHAVWYLTTRPIPGLQQIHNDHATGNETDSDGRMNPGQMAYISSRSCSIPDESYGCL SANIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLY LSRPEYNFLLNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNE NDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSP QLAKLQESFITHIVGPLCNSYDAAGLLPGEWIEAEEDEDAESCYDEEEGEELDTDDEEIE DNLNPKPRRRKGRRRIFCQLMHHLTENHKIWKEIIEEEEKCKADGNKLQVENSSLPQADD IQVIEEADEEEERQFE >Gallus gallus_PDE3B(ENSGALP_3882) MILWDWDLKQWYKPYYQNAGSGTGVDLSVLNEARSMLTDLLTDPSLPPQVISSLRSINSL IGAFSGTCRPKANPFTPFPGFFPCPEVDDPAEKGDRKPLKGLISRNSLPTPQLRRSSGVS GIPPIESPSSKWERSNSKRPHQDYNVSSQGSHSNGSFGANLLAIPKQRSSSLTLAHHMGS RRAGASPGLSPVGSPTHGSVSSGSWSPVEFPDTADFLTKPSININKPPAHTFSSPDYQQQ VKTPVGYVCSSCGRQILKPIPSLEEEFVEYKDKKSGEVGSSSLSKEPFHQAEETKDEKKE IITQTQNNSLVVQSPKLETMITEHESLMEKMNNWNFQIFDLVQEMGDQSGRILSRVTYTL FEDTGLFEIFKIPIKEFMNYFCALEDGYRDIPYHNRIHATDVLHAVWYLTTRPIPGFQQI HNEHVLATDMDEAGGGVHDQVSYISSKSCSITDDSYGCLASNIPALELMALYVAAAMHDY DHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLFLSRPEYNFLSNLDHVEFKRFR FLVIEAILATDLKKHFDFLAEFNSKANDIDSHGIEWSNENDRLLVCQICIKLADINGPAK VRELHLKWTEGIVNEFYEQGDEEASLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSY NAAGLLPGQWVDEEEGAESNEDDDGAQLESDDEEIEDDLILKAQRRKGRRIFCQLIHHLS ENHKIWKKAIEEEEKAEGAKLLTEISSLPQADEIQVIEEADEEDERQLGEEKTC >Anolis carolinensis_PDE3B(ENSACAP_12439) MNSRNSLPTPQLRRSSGATGLLPIEPSSRWDRSTGKRVHLEYNSSSQGSYPNGPLNTNLL TIPKQRSSSVTLAHSIGSKRAGTSQNPIPMTSPSSGFIFGGYHRSPVEFPDTADFLTKPS INMNKSLGCTFSSSEFQQQIRTSSHYTCSSCGRQLFKSVAASLSESVAEYQNHKTGEDGN TDVSKDSAHFIEKQQSETGEIKNHNNWMDQTKKLMALEDHDSLIEKMNTWNFQIFDLVKR MGDKSRRILSQVAFTLFQDTGLFESFKIPTRQFMNYFQALENGYRDIPYHNRIHATDVLH AVWYLTTRPIPGFQQIHSVSVTGADSDTENGILAGHVSYVSSKSCTILDENYGCLASNIP ALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWSLFLSQPE YNFLPNLDHVQFKRFRFLVIEAILATDLKKHFDFLAEFNAKVNDINGHSIEWSSESDRLL VCQICIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEASLGLPISPFMDRHSPQLAKL QESFITHIVGPLCNSYDAARLLPGQWVDEKDNESSDEYDAGELDSEEDEIDDFGTKLQRR KRQQIFCQLIHHLNENHKIWKKITEEEELNKSEESKQAENTSLGQSDEIQVIEEADEEEE HHQGEEKTF >Danio rerio_PDE3B(ENSDARP_84073) MAVREEGEVLHSKIRQQQHDGVVGNANSAESFRNGYVKSCVTPLKQDHPRGFLFNVCRFC NEDILKSKLFRGSAIYVGALAVLALSCFVSRSFQSEHGVLELRTFLLDFSQSVSPLFSIG CAYFFLTLYLRRTKRESSRCWLLSLPASCYLGDLMVVRLLQWGEEHHQMQMMGRLLFVLG CVGLLTLVPTLKLKHSVLILVFASLVWLLSFTSLGCLSPSLRPVLSCVAGVSGSLLALCF DHYYPPRESAGRVPNAEEKVPVIRPRRRSSCVSLGETSTSYYGSCKMPRRPSLPCISREQ MILWDWDLKQWYKPQYQGAVSGNGVDLSVINEARNLVSELLMDPSLSPHALSSLRSVSSL MGAFSGSCRPRVNPFTPFPGFYPCAEMDDPSERGERKPVKGLSSRNSLPTPQLRRSSASS SLPPLDPASSRWERTNGKRSHSELSSFVSNGPNSNLLTIPKQRSSSVTLSYGHTLSRRPG ASPSLSPVTSPSHSPPAGPGSSLVTRSPVEFPDTADFLTKPSVNLHKPLGYTMSSPDFQQ QYRTSASTPLCTSCGRQMLKGVPSVEVVEGHHTTANEMQRTRSADGAEYGGENLIREESL EAESQEERTSDTAGEKVNSQPEEEEQTSSTEQSSLDPEGDEEFRLDLMLVEHEELMEKIN TWNFQIFELMDLTGGKTGRILSYVAYTLFQDTGLFEIFKIPVREFMTYFCALENGYRDIP YHNRVHATDVLHAVWYLTTQPIPGFQQIHNEHVTGSDTDSDSGISPGRVAYATSKSSSFQ DDSYGCLAWNVPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHA ASAWSLFLSRPEFNFLCNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNSKVNDVNSP GIDWTNENDRLLVCQVCIKLADINGPAKDRSLHLKWTEGIVNEFYEQGDEEGTLGLPISP FMDRSAPQLAKLQESFITHIVGPLCNSYDAAGLLPGYWIDEEGSDDEEETEDNETEDEEL DEDLEPKRRKRRRRLFCNIMQHLTENHKVWKKTIEEEEKAKELETQQKQQQQQQSEGPSL PPSTSSSDDIQVIQEEAEEEERQ >Takifugu rubripes_PDE3B(ENSTRUP_44336) RPVVPTVASADMILWDWDLKHWYKPQYQGASTGNGVDLSVINEARNLVSDLLMDSSLPPQ SVSTLRSISSLMGTFSGSCRPRVNPFTPFPGFYPCDEVEDSAERSERKSIKGLSSRNSLP TPQPRRSSTSSSCSTLPSLDSASARWERNTGKRSHPDLNLSSPGLSNGPNANLLTIPKQR SSSVTLTYHAGPRRSGASPSLSPVASPAHSPVAMGMGSTSSLIRPPVEFPDTADFLTKPS VSLNLHKPLASTLSSPDFQQAFRGAAFPVCTSCGRQIAKGGDTSRLPFSNEAQRRREESV EMEASADGRQDAAGKLVQTEEEEEEEAAEESSSTEQPTQEAEVEQEFILDPVLEEHETFM EKMNTWNFQIFELVDKTGGKTGRILSYVTYTLFQDACLFEIFKIPVREFMTYFSALESGY RDIPYHNRVHAADVLHAVWYLTTRPIPGFQQIHSEHVTGSDTGGMISYASSKSCSISDDS YGCLAWNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAAAA WSLYLSQPEFNFLVNLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNSKVNDVNSPGID WTNENDRLLVCQVCIKLADINGPAKIRDLHLKWTEGIVNEFYEQGDEEAKLGLPVSPFMD RSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGYWINQEGSDEDDEEGQVETDTDEEEDD EMEDELEPTAERRKSRRRLFCSIMQHLAENHKVWKKTIEEEEKSKELGKPQQQPDSLPSS LPTSPSDDIQVIQEEEEGEECDERMSGEEGSA >Homo sapiens_PDE3A(ENSP_351957) MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRK LSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAP GGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGV GEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYL AYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEM SGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDL LADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLA IPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWN NPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVS KISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADE PLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYA PETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFE DMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVIN DHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDH PGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFL VIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKEL HLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAG LMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLL QNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPD Q >Macaca mulatta_PDE3A(ENSMMUP_10834) MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRAEPASPRDSGCRGCLGDLVLQPLRRSRK LSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAEEEEEAAPGAEGGVFPGPRGGAP GGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGV GEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYL AYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEM SGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGSRGSQSSGTSITVDIAVMGEAHGLITDL LADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLA IPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSRWHTAP AGRLTHYIWLEVSFEYGKANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKIS AVQFPESADTTVKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLE RSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPET MMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMG LFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVISDHG STSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGR TNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIE AILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQ WTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMP GKWVEDSDESGDTDDPEEEEEEAAAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNH KMWKKVIEEEQRLAGVENQSLDPTPQSHSSEQIQAIKEEEEEKGKPRGEKIPTPKPDQ >Mus musculus_PDE3A(ENSMUSP_38749) MAVRGEAAQDLAKPGLGGASPARVARGNHRHRGESSPSPRGSGCCWRALALQPLRRSPQL SSALCAGSLSVLLALLVRLVGGEVGGELEKSQEAAAEEEEEEGARGGVFPGPRGGAPGGG AQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDG RLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVAWTSVLRTVALVSLERFKVAWRPYLAYL AAVLGLLLARYAEQILPQCSGPAPPRERFGSQLSARTKEEIPGWKRRRRSSSVVAGEMSG CSGKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSGTSITVDIAVMGEAHGLITDLLAD PSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKQAISK RLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWN APGLTTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLAKISPVPSPSSSPPQGSPASSPVS NSASQQFPESPEVTIKRGPGSHRALTYTQSAPDLSPQIPPPSVICSSCGRPYSQGNPADG PSERSGPAMLKPNRTDDTSQVTSDYETNNNSDSSDILQNEEEAECQREPQRKASACGTYT SQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLMENIGRKCGRILSQVSYRLFE DMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIG DHGSASDSDSDSGFTHGHMGYVFSKMYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDH PGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFL VIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKEL HLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAG LMPGKWVDDSDDSGDTDDPEEEEEEAETPHEDEACESSIAPRKKSFKRRRIYCQITQHLL QNHMMWKKVIEEEQCLSGTENQSLDQVPLQHPSEQIQAIKEEEEEKGKPRAEETLAPQPD L >Felis catus_PDE3A(ENSFCAP_905) MGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLL STQLTFQAIHKPRVNPVISFSENYTCSDSEENSEKDKLAIPKRLRRSLPPGLLRRVSSTW TTTTSATGLPTLEPAPVRRDRSASIKLHEAPSSSAVCPDSWNNPVMMTLTKSRSFTSSYA VSAANHVNSKKPNRPGALAKISPLSSPCSSPPQGTPASSPVSKISAVQFPESANTAAKQG LSSHRALTYTQSAPDLSPQILPPPVICSSCGRPYPQGTPAAVPLERSSAAIRTPSRTDDT TQVTSDYETNNNSDSSDIVQNEDETECPREPLRKASACGTYTSETMIFLDKPVLAPEPLV MDNLDSIMEQLNTWNFPIFDLVEKIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNY FHALEIGYREIPYHNRIHATDVLHAVWYLTTQPIPGHSTVINDHGSASDSDSDSGFTHGH MGYVFSKMYNVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL YNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVA KFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTEGIVNEFYEQGDE EASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDD PEEEEEEEEAPNEEETCENNEAPNFYRNNSFSLNRRVQCIYXQHLLQNHKMWKKVIEEEQ RLAGIESQSLDQSPQQHSSEQIQAIREEEEEKGKPRGEEIPTL >Gallus gallus_PDE3A(ENSGALP_36646) MGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRTVSNLL NTQLTFQAIHKPRVNPLVSFSENYTCSDSEECPEKGEKLAIPKRLRRSLPPGLLRRVSST WTTTTSATGLPTLEPAPVRRDRSASIKPHESSSSSKVNSTDSWNSSLLMTITKSRSFSTS YAMSPTNHLNAKRQSRQGIPPNISPLTSPCHSPLQGTPATSPTGKTSSVSFPDSTDTDTK QGLKPHKVLTATQSAPSLSEPNISPSVICSSCGRPYNQIEAGDGTLDRSDGTTHTLNRTD DPAQATSDYETNNSDSSDIVQNDDETDCSKEKARKGSVCRTYAPETIILQDKPVLAPEPL VMDNLDPLMEQLNSWNFPIFDLVEKIGKKCGRILSQVSYRLFEDMGLFETFKIPVREFMN YFHALECGYREIPYHNRIHATDVLHAVWYLTTQPIPGLPTVINDHGSASDSDSDSGITHG HMGYVFSKTYTPTDDSYGCLAGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAV LYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFV AKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKDLHLQWTEGIVNEFYEQGD EEASLGLPISPFMDRSAPQLAHLQESFITHIVGPLCNSYDSAGLMPGKWIEDSDESGDTD EHEEEETAEMETCENAESRKKKFKRRKIYCQITQHLLQNHKMWKKVIEDEERLAGTEKQG AEQSTLHPSSEQIQAIREEDEEKGKPKRDEEENTTVEPNQ >Anolis carolinensis_PDE3A(ENSACAP_17252) MGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLL NTQLTFQAIHKPRVNPLASFSENYSCSDSEECSEKGEKLKRIRKNLPPGLLRRVSSTWTT TTSATGLPTLEPAPVRRDRSASIKLHDTSSSSSDSWNNPLLMSITKSRSFSASYAMSAAN HLNSKRPSRQGIPPNISPLTSPSHSPIHGTPAHSPTSKTSNEQFPESTVTASKQTLKPHK VLGCTQSAPAIAEPVLPSPVICSSCGRPYNQIEPGEGTLDRSDGTAHTLNRTDDPAQATS DYETNNSDSSDIVQNDDETDCSKEQAQMDSNCRTYTPETIILHPLLPSEEKPILAPEPLI MDNLDPLMDQLNNWNFPIFDLVDKIGKKCGRILSQVSYRLFEDMGLFETFKIPVKEFMNY FHALECGYREIPYHNRIHATDVLHAVWYLSTQCIPGLPTVINDHGSASDSDSDSGITHGH MGYVLSKTYAPADDTYGCLAGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVL YNDRSVLENHHAAAAWNLFMSRSEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVA KLNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKHKDLHLRWTEGIVNEFYEQGDE EASLGLPISPFMDRSAPQLANLQESFITHIVGPLCNSYDSAGLMPGKWVEDNDDLGDTDD PDEEDSTDMDTCENPESRKKRRKIFCQITQHLVENHQMWKKVIEEEERKAGIEKQALEQP ATLHPSSEQIEAIKEEEEEKGKPKPEEDSTIPETNQ >Danio rerio_PDE3A(ENSDARP_119110) MALESVRNGYVRTCVTPVEQDCWHSCLRSRRSLSSAVCVASLSVLLALLWDAERTHAHSG SHLVTLVELVWQLLSPVLTLVCAFFWVGVYLLRCGVLIRTAVFLLTVCHLGEAAAQSLLD AQQLYSFTATALVLLACLASGALMVVRLGQGISVLLFISIIRTVSLLSLQKVRASWRPYL AYLLGLLGVLLARYADRLLPEQGASHREGSRGDIPVFKRRRRSSSVVSSDMAQHGQSRSK SHRRTSLPCLQREQMLPQQEWDNKRGARGSQSSGTSVTVDIAVMGEAHGLISDLLADQSL APNICSTLRAVSNLLNTQLTFQPLHHRPRLGPLLAFSDGHTCSDSEEAPEKGERLAIPKR LRRSLHPGLLRRISSTWTTTTSATGLPTLEPGPVRRDRSASIKAPHDGPSSSLVNSDSWN NSNMLSISKSRSMSASYAASSNTTNHIYSKSRRGCSSSTISPLASPCHSPPVQSSPLTSP TNKTPSVELPDPELPPPRSPHKALTHSQSAPSSSAALWPPPTPLCSSCGRPYSKQRHSDG STEPAERTQQSDEPAMMSSDYDSTYETNHSDSSDFAQTDEDREARRTLTLATLIPAEEKP ILAPEPLLMEGLEPLLCQINNWNFPIFSLVEKTNGRCGCILSQMSYRLFVDTGLFETFKI >Takifugu rubripes_PDE3A(ENSTRUP_43548) LFTLLCAFFWVGVYLIRCGVLIRTTLSLLTLCHLGAAAAWSLLDGTDEQLFSFTTAAVVV LVCVATGALMVARLNQGISVILYISIVRTVSLFSLHKVRANWRPYVAYLVGVLGILLARY ADELLPNQGRHKEGCTPVTGAREEIPVFKRRRRSSSVIASDMAHSQSSSKSHRRTSLPCI QRDQMLSRSEWDHKRGSRGSQSSGTTVMVDIAVMGEAHGLITDLLADPSLPANTSTSLRA VSKLLSTQLTFQPLHRPRPVPLLSPSDAYTLSDSEDGPEKGEKTSIHKRLRRSLHPGLLR RISSTWTTTTSATGLPTIEPGPVRRDRSASIKQYHETLTCSEGRAANASSFQWDLAKTAP RFRGAGEELFNDSCSVNPCSSANGPRLQGPIQLSAPSQKTEKRIGGASASSSTFIKSISC PEKAGFTTFRGCRYYSLPRRQSVAFLCALKIPSLLVHICGRSYIKLSHGEGSLDKGDRLP RSAEDHVVVSSDYDSTHEANHSDSSDVAHTEEDTEEGKSSAQNVILHQLIPPEDKPILAP EPLLMEDLDPWMSQLNNWNFPIFTLMEKTNGKCGQVLSQVAYRLFEDTGLFETFKIPVKE FMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTQAVPGLPSLVADHGSASDSDSDSGI THSHMGFLVSKTYTVSEDGYGCLSGLIPALELMALYVAAAMHDYDHPGRTNAFLVATSAP QAVLYNDRSVLENHHAAAAWNLFMSHPEYNFLVNLDHVEFKRFRFLVIEAILATDLKKHF DFLAEFNAKVGDDPSTGIDWSNENDRLLVCQMCIKLADVNGPLKCKDLHLQWTEGIVNEF YQQGDEESSMGLPISPFMDRAAPQLAKLQESFITHIVGPLCNSYDSASLIPGRWVEPNPE ADEPESTENEEDEEDTAEEDISTSSETSQKAAPKKRRKVFCHITQHLLENHEMWKKVIAE DAQKQAQGGESVLLNNVAEPILAIHEEEEEPGSREELAEGEEPEE >Gasterosteusaculeatus_PDE3Aa(ENSGACP_13254) WVRLMFSKIRSSHRIRSVVCVGSLSLLLALLVKCADWRAETSSSADNRLSHTSSLFHLVS GCAAELLQTCWSVVPPPLTLACAFFWVGVYLIRCGVLIRTVVSLLTLCHLGEAAARSLLD GTDERLFSFATAAVVVLVCVAAGSLMVARLNQGISVVVFISLVRTISLFSLHKVRATWRP YVAYLVGVLGILLVRYADKLLPNQGRHKEGCTPVTGAREDIPVFKRRRRSSCVVASDMAH SQSNSKSRRRTSLPCIQRDQMLPRSEWDYKRGSRGSQSSGTTVMVDIAVMGEAHGLITDL LADPSLPPNTCTSLRAVSNLLTTQLTFQSLHRPRPASLLNPGDAYTFSDSEEGPEKGEKT SIHKRLRRSLPPALLRRISSTWTTTTSATGLPTIEPGPVRRDRSASIKPFHEALTCRYHH SNKPSKSTCSKSLSNAKTYMTHSTVFSTRRPGKKGPIESPLRSSEPPARELLSSSPSISF PKEAAFTTFGESYGQPRLALSTNIWRTGLRLTPNVFYSNIFCRFGCGRPYIKLSHGEGSI DKGDRIPRSAEDQAVVSSDYESTHEANHSDSSDVAHTEEDTEEGKNPGQNVILHPLIPPE HLSQDQPILAPEPLVMEDLQPLMSQLTNWNFPIFSLMEKTNGKCGRILSQVSYRLFEDTG LFETFKIPVNEFMNYFHALENGYRDIPYHNRVHATDVLHAVWYLTTQAVPGLPSLITDHS SASDSDSDSGITHSRVGFLVSKTYTVSEDGYGCLSGLIPALELMALYVAAAMHDYDHPGR TNAFLVATSAPQAVLYNDRSVLENHHAASAWNLFMSRPEYNFLVNLNHGEFKRFRFLVIE AILATDLKKHFDFLAEFNAKVGDDPSTGIDWSNENDRLLVCQMCIKLADINGPLKCKDLH LQWTEGIVNEFYEQGDEESSLGLPISPFMNRAAPQLAKLQESFIAHIVGPLCNSYNSASL IPGRWVEPNHTSTSSEASRKNNVVVQSYEAKVVAQLSISFPEKGTSKKRRKVFCQITYHL LENHEMWKKVIAVEAQQQGQGAESVHLNNVAEPILAIHEEEEEPGSREELVEGEDLEE >Gasterosteusaculeatus_PDE3Ab(ENSGACP_11543) YCVHPVCALACAFFWGGLYLLRCGVLIRTAVFLLAVCLLGEAAAQFLLRGAEEEQLLSHP ATLVVLGCLGSGALLVVRLRQGVSIVVFVSVIRAASVVSLGSLRASWRPYLAYLLGLLGV LLARYADRLRPAPGTSGTGCCGSVTGAKEEDIPVFKRRRRSSSISASEMMAHSQSNSKSH RRTSLPCIPRDQLHIMCQPEWDFKRALSRSQPSSTSVVVDIAVMGEARGLISDLLADPSL PPNTCSSLKAVSNLLGTQISLQPLHRLRIPADTHTCSDSEEGPERAERLAIPKRIRRSLP PGLLRRISSTWTTTTSATGLPTLEPGPVRRDRSASIKHTGDRLSISESWNNSVMMTISKS RSMSASCAVSVTSNHLHGKPPGRRFPSSNESPLGSPCPSPPVQGTPVSSPTVTTCSVQLP EPPGPLAERSPDPVAHKSHHKALTHSQSAPSSTTPYWRPPSLCGSCGRPFNHRLNRRAES ADKGDRIPHPDERAVASSDYDSTYDSTYETNHSDSSDFAQNEEEGEGGKKLPEEKPILAA EPVTLPELEPLLSQLNNWNFPIFSLVEKTQGCILSQVSYKLFEDTGLFETFRIPVQEFMN YFHALENGYRVIPYHNRTHATDVLHAVWYLTTQPVPGLPTALTENGMNSVDSENGINAGA TCFLVSKMNSVLEDGYGSLAGLIPGLELMALYVAAAMHDYDHPGRTNAFLVATSAPQALL YNDRSVLENHHAASAWNLFMSRPEYNFLANLEHVEFKRFRFLVIEAILATDLKKHFDFLA EFNAKVGEEGVSGIDWTNENDRLLVCQMCIKLADVNGPLKCKELHLQWTEGIVNEFYEQG DEEATLGLPISPFMDRSAPQLAKLQESFIAHIVGPLCSSYDSAALMPGCCVDLPEGESDP EEEKDEEKEERDTEQDGMTDEEASTSSNTSQERETKKVSRRKVFCQITQHILENHEMWKR VIAAEEEAERADPNCIGSPTDPITSIHEEEEEQASKEESVDGLDQSESSGEKEEDP >Oryzias latipes_PDE3Aa(ENSORLP_5649) SSRRLASAVCVGTLSVFVAALVKRAEWRAEASSGADGALSQALSPLLLVAGCAAELLQTC WSAVSLLFTLVCAFFWVGVYFIRCGVLIQTALSLLTLCHLGEVAAWSLLDGTDEHLFSFT TAAALVLVCLAAGALMVARLNQGISVIVFISVVRTISLLSLQKVRATWRPYVAYLVGVLG ILLARYADKLLPNQGRHKEGCTPVTGSREEVPVFKRRRRSSSVIASDMAHSQPNSKSHRR TSLPCIQRDQQMLSRSDWDHKRGSRGSQSSGTTVMVDIAVMGEAHGLITDLLADPSLPPN TCTSLRAVSNLLTTQLTFQPLHRPRPAPLLNPNDAYTCSDSEEGPEKGEKTSIHKRLRRS LHPGLLRRISSTWTTTTSATGLPTIEPGPVRRDRSASIKPYHESLTCRKTFNSRKIFDLT RTEVFPTQRDSQLLQPLNGALKKKKTQTGKLTRMSPLSSLCHSVPVGGQLSSTNTDTSSF TFTEKLNLVSQMLLAAWTPLTILTVHPSLKPTFVFFPILCCNCGRPYIRLSHGEGSVDKG DRIPRSASPTEDQVVVSSDYDSAHEANHSDSSDVAHTEEDTESPQRKSKNISNTFKFYNF FMDKPILAPEPLLMEGLDPLLDQLNSWNFPIFTMMEKTNGKRGQILSQVSYKLFEDTGLF ETFKIPVKEFMNYFHALESGYRDIPYHNRVHATDVLHAVWYLTTQAVPGLPSLLTDHGSA SDSDSDSGITHSHMGFLVSKTYTVSEDGYGCLSSLIPALELMALYVAAAMHDYDHPGRTN AFLVATSAPQAVLYNDRSVLENHHAASAWNLFMSHPEYNFLVNLDHVEFKRFRFLVIEAI LATDLKKHFDFLAEFNAKVGDDPTNGIDWSNENDRLLVCQMCIKLADINGPLKCKDLHLQ WTEGIVNEFYEQGDEESSLGLPVSPFMDRKAPQLAKLQESFITHIVGPLCNSYDSAGLIP GKWVEPNPDEEDTEAAENDEDEEDTVEEDASSSSEVSEKATLKKRRKVFCQITQHLLENH EMWKKVIEKEEEEAQNAGQGTDSVHLNNVSEPILVIDEEEEESGSKEEQVEGERPEE >Oryzias latipes_PDE3Ab(ENSORLP_10351) FQSSGTSVVVDIAVMGEAHGLISDLLADPSLPPNTCSSLKAVSNLLSTQISLQPLHRPRI PPDTRPCSDSEDGPEKPERLALPKRSENLNSRNSWPSPFTLFKTEEGLVSLLNKLTSSQS YKGKQTTHSVILSLLGVSPECPGSSLEFPIRKDMASFLYLTFTKPLGRSGGTPVPSPTIK MCPVQLPEPAGPQTERTPVSVAPKSHHRALTHSQSAPNSTTIHWRPPSLCGSCGRPFNNE RAVALSDYDSTYDSTYETNHSDSSDFAQNEEDGEGGKKPSVLRESCRECPAEDIVLHPLL PSPEVANGTSTRTPMMPELEPLMSQLNNWNFPIFSLVERTHGKTGCILSQVSYRLFEDSG LFETFKIPIKEFMNYFHALENGYRDIPYHNRIHATDVLHAVWYLTTQPVPGLPTLRTENG IHTATNSANGITPRATSFLASRINLELEEEYGSLAGLIPGLELMALYVAAAMHDYDHPGR TNAFLVATSAPQALLYNDRSVLENHHAASAWNLFMSQPEYNFLMNLEHVEFKRFRFLVIE AILATDLKKHFDFLTEFNAKVGDEGVSGIDWTNENDRLLVCQMCIKLADVNGPLKCKELH LQWTEGIINEFYEQGDEEASLGLPISPFMDRSAPQLAQLQESFITHIVGPLCHSYDNAAL MPGRWVDLAEGGLEIDMVKEGQGTEEEDTADEDASTGSDTSQQHEAKSKRKVFCQITQHL LENHEMWKRLIAAETPEETQAEVPICISSPTDPI >Ciona intestinalis_(ENSCINP_32055) ESVLLLELAREISDTDDQDKFCFQALRHVVSIVNAEKCSLFWMRDSAKGDSKELASRLWN ITPKSTFDDVVCDSKNELVVPVGVGIAGLVAETKEAVIVSNVYEHPNFNKTIDEKTGFES RDLLCQPLVLKREDKVVGVVEVVNKKNKEPFTTEDAQVLEHFLVLCNLAIQNCRGAAQIT RLQQAATVSFLWQVNILFVGLSYYRIRFHKEVVMQISDLIQCERYTLAIALIDNCNIEGC LQFAKSYDLLLQKPKASMFDDEDQPIVKTVEVNNIAGYIFIYKKKQQSITNGIADVLRFL SMHSTLTAANCTKTLLNDICFIFMFEECKLLDDAKKEFSLKSALCVAFYDGTDRLLGVLH LGNKKKKGFDENDEAVIQSVRPYIMNGLLFANGFNSIVINKAKTDVAEDTVRFHIRPWQD EVDRVVVSLAVYGNRKWSLIIMDAAFFSQNEPIPEGEKYNLYQFTFSDLLMSDDETVMGA MRMFLDLDAFNLFHIRQETMLRWLITTRRCYRPVYYHNWRHGLNVAHTMFLLLDRMTPGI DKAFNDREKFALVVACFCHDIDHRGTNNAFLIRAGAPLAILYNTSTLENHHYDTCLRISS IDGNNIFESFTKEQFESACELMKHAILATDLALYFQRRNTFKKLLEKPFEERDFVQNNDN RMLLMSMMMTACDLSSITKPWEVQQKMAKLVTSEFYDQGDQERALFGTEPMPMMDRRKID DLPKMQIGFIDGVCSMAYEMMADFCPGYAPLRDGMRANRQSWKDLASE >Ciona intestinalis_(ENSCINP_10920) EEYIIANVRLETLNRWCTKKRSQLQNDSVAGEGKRILEKETKSIYNNSELLFEKISTGNY LHPLYMLCSHLQTSTMSTSFTFYAVGGTCDTIHLYNPELPQWQNDPPPESRTSILPSYPV EEGGTVASHVASTQQSVTIDDITMDERFPKGTSTLESAAVSVMCLPVALPNGDLIGVVEF CRAWHNAEYTFETLAMAQTTLTWATMAIDKTQVSSGLEQQNAMSNFLLQVSRTYLDDITD VDNIIQHIMRFAKTLVSADRCALFLHDKEAGELYSNLFDNGEVMDGKSVFSKKTELRFSV TKGIAGASVRTKQTLNIPDAYSDPRFNRAVDKATGYTTKSILCIPIMSNDEVYGVVEMIN RKDGGSFTMNDQNNFQMFAVFCALALRYSKVHTRLQKDQCRHAILKEKYFYHSQYSKADY NELIKAQKDDETFVLPPNFDRFHFSLFHLDKKLMSYFINMVIELAGSGSHLLPSANVMTD FILTVRENYRDIQYHNWQHAMTVTHAMFCMLKQNLEIFDEVERYALLVACVCHDLDHRAR SNQFLQKTSHPLALLYPASTMEYHHISMAKDILGRKESKVFQNMTNEEYEKAMYVLKEAI LATDLALYFGNRGQIEELLTQGEFDFDNQQHRTSAIGLMMTACDLSSSAKDWSVTRQNLL DLHYEFWEEGDQRKKLGIKPLLPMMDRALEEDLAEGQVGFYSNVSIKCFESLARVLPSCE PLAIRGKENLGHWRKEAEIVKEKKEEKRKIAEKEKQREERLKQEGLGLTLRGGMWVVEES RPTS >Ciona intestinalis_(ENSCINP_11667) MLLGVRLTKGGSSNQICNESQHYLSNFSHDHIPERHVSQSISHSNNCSKETFNKTKRTPS TRVLSDAAHRLDAFMPCVVLMKKQASISHKQCLSIGMHPNPRKTKRRASLDVIKEHNVLT EGLRWRDVMNRRRTSLPAILASSKRKAVMSSTLVDTSTLVEIQSTLEKLGKSPALVESLV EDLQNLLKPYKTDHVRPRQVVWLHDSGTDGSDDDVVSTPRHSAGKRSASRRNEWNPSKDI FSTTTTATGLPTEEPAPAKPKRLPKISKEKSPLVSPLDSRCSSPVIDSSIRANLGRRKTY PSLPSSGSQVYFPSSHNLLSVHKKFPTVSSDYESCDNDDVTSPIARSKSVNEKDSDPLDL HHLQHHLHHDEEDNEFLTSTSQLDDDITIMEEVVTCRGNQWSDDELTDDGYNFFLHYQQK LLESVYKWNFPIFTLAQQTDCVLSQMAFKLFQDTGLFETFKIPKQEFVQYMRALEEGYRN IPYHNRIHAADVLHGCWYLSTQAIPGFHESSALFSSDSSDSDSGTGTSHNHCQVNNIGHG SLAQAIPALELMSLYLAAAMHDYDHPGRTNAFLVETRHPLAILYNDRSVLENHHASSSWG LLYSDPRFNFLKNLDTAEWKRLRFLVVEAILATDLKKHGEILSQFSVKSQNGLNWSADAD RLLVCQMVIKLADIGGPAKERNLHITWTKAICEEFFIQGDEERELGVPVSPFMDRERPQV AELQRTFINNLIKPIVQSMYKTGILAGKAEDNEADESPMEDQSQCLLLEQLKDNLNFWEV KTPTSGHEEMNEAFKLALHVDLSMRNSRTNLNIPNHTEPIDDVIITNKTDNDVNNKQQCN DCVTTNNTTIRNSPSKLGTIPKLQPPKIVINHKVSSHTS >Ciona intestinalis_(ENSCINP_11667) MLLGVRLTKGGSSNQICNESQHYLSNFSHDHIPERHVSQSISHSNNCSKETFNKTKRTPS TRVLSDAAHRLDAFMPCVVLMKKQASISHKQCLSIGMHPNPRKTKRRASLDVIKEHNVLT EGLRWRDVMNRRRTSLPAILASSKRKAVMSSTLVDTSTLVEIQSTLEKLGKSPALVESLV EDLQNLLKPYKTDHVRPRQVVWLHDSGTDGSDDDVVSTPRHSAGKRSASRRNEWNPSKDI FSTTTTATGLPTEEPAPAKPKRLPKISKEKSPLVSPLDSRCSSPVIDSSIRANLGRRKTY PSLPSSGSQVYFPSSHNLLSVHKKFPTVSSDYESCDNDDVTSPIARSKSVNEKDSDPLDL HHLQHHLHHDEEDNEFLTSTSQLDDDITIMEEVVTCRGNQWSDDELTDDGYNFFLHYQQK LLESVYKWNFPIFTLAQQTDCVLSQMAFKLFQDTGLFETFKIPKQEFVQYMRALEEGYRN IPYHNRIHAADVLHGCWYLSTQAIPGFHESSALFSSDSSDSDSGTGTSHNHCQVNNIGHG SLAQAIPALELMSLYLAAAMHDYDHPGRTNAFLVETRHPLAILYNDRSVLENHHASSSWG LLYSDPRFNFLKNLDTAEWKRLRFLVVEAILATDLKKHGEILSQFSVKSQNGLNWSADAD RLLVCQMVIKLADIGGPAKERNLHITWTKAICEEFFIQGDEERELGVPVSPFMDRERPQV AELQRTFINNLIKPIVQSMYKTGILAGKAEDNEADESPMEDQSQCLLLEQLKDNLNFWEV KTPTSGHEEMNEAFKLALHVDLSMRNSRTNLNIPNHTEPIDDVIITNKTDNDVNNKQQCN DCVTTNNTTIRNSPSKLGTIPKLQPPKIVINHKVSSHTS >Ciona savignyi_(ENSCSAVP_15022) MSLYLAAAMHDYDHPGRTNAFLVETRHPLAILYNDRSVLENHHASSSWGLLYSDPRYDFL KNLDTAEWKRLRFLVVEAILATDLKKHFVILSQFGVKSQNGKGISWSADEDRLLVCQMVI KLADIGGPAKKRNLHMTWTKAICEEFFIQGDEERELGLPVSPFMDREQPQVAELQRTFIN NLIKPIVQSMHKSGILAGKVEESEESEVVESNESLLLEQLKDNLNFWKAKQPACGHEEMN EAFKLALPVDLSIRETNPAFSTQRVNVTITDNPICRVNKPDNLSSTEGITSSQHIVSSKP >Ciona savignyi_(ENSCSAVP_15022) MSLYLAAAMHDYDHPGRTNAFLVETRHPLAILYNDRSVLENHHASSSWGLLYSDPRYDFL KNLDTAEWKRLRFLVVEAILATDLKKHFVILSQFGVKSQNGKGISWSADEDRLLVCQMVI KLADIGGPAKKRNLHMTWTKAICEEFFIQGDEERELGLPVSPFMDREQPQVAELQRTFIN NLIKPIVQSMHKSGILAGKVEESEESEVVESNESLLLEQLKDNLNFWKAKQPACGHEEMN EAFKLALPVDLSIRETNPAFSTQRVNVTITDNPICRVNKPDNLSSTEGITSSQHIVSSKP >Ciona savignyi_(ENSCSAVP_9294) MATEAQLNRELVEAWLDDHAEFAFDYFTRKATQTMVNTWLADRVIRIAGSDRKISSIERS PTKHDNDPTIRPPSTSGDSTGRKTPIRKISHEEIKPGHLPLKPMVLTDEMGSPSFYTPDS ATSPSLTRRMNNQRDMIMDLVIDIASDLDVTSVSHRILQNVSILVDADRCSLFLMRERDG EKFLVSRLFNVSKESTLEDNVVVKDEIKMKLGQGIAGMVALTGTTLNIPDAYKDHRFNQS VDKKTGYRTRSILCMPIRDGDKRIVGVAQVINKTEGAFTSKDEKIFASYLGFCGVAIHNA QIFEKVQLENRRNEILLDLARVLFEEQSSLSTVMDTILTHTVSLLSCERASVLLANPSQP ENVFEHTFEHVDESTITSNLNFDKNSPQRNKVPLNIAITSYVRQTGQIVNIENASSDQRF EFLEDTELGFTTRSLLCIPIWDSFRQVIGVIQLINKHHRVGPRFTKSDEQILEAFAIFCG LGISNTRMYEETARLAAKQQVILEVLSYHAVASPLETNALLTNDIPSSKSLGILKYEFDD TTLSDLDTVRASVRMFIDLKLVEKFRINHETLCRWVASVKRNYRPVSYHNWRHAFNVCQS CFCMVKTGGLDTVFSDFEKLALLVSCLSHDLDHRGTNNAFQAKIEHPLARLYSTSTMEHH HYNQCLMLLQSDGCEILSHLSSTEYAQVIKLIQHAILSTDLAIYFKKRGEFFNILRSENA DWKGNDSHRELLRSLVITGCDIAGITRPWKVQKEIAQLVAEEFFEQGDIEKTKLHQEPPD MMNRKLKHKLPKMQIGFIDSICLPLYEALSDVEPGLQPLLNGCLDNRRHWE >Ciona savignyi_(ENSCSAVP_900) YQYKVGLVYFQPKSHNPFIFMKITDGNYLYPLYLLCGQLQIATLSTGFTLYAVGGSGDTI HLYNPELPEWKDNPPPQNRYQIGKHGTVASHVAVTRQPVVVHDVNMDDRFPKGTSSQDSD ALSVLCMPIALPNGDLLGVVEFIRTWHKAGYTLDTVEMAQTFFTWATMAIHKTQVSCGLE KQSAMSNFLLEVSRTYLDDLTDVDNIIQHIMRFAKSLVSADRCAFFLHDMEREELYSNLF DAGEVIDGQTVFSKDTEIRFHVSKGIAGAAVTTKQILNIPDAYSDPRFNREVDKATGYTT RSVLCIPIMGGDEVHGVVEMINRRGGGAFTMTDQNNFQMFAVFCALALRYSKVHTRLQND QSRYMILKEQYCYQSRYSNEDYENLTLLQQDEDNFVLPPNFDRFYFSLFHLDKELMGYFI KMVHNSADTCSLLPPADVLTQFTLTVRANYRNIHYHNWQHAMTVSHSMYCMLKDNVEIFD EVERYALLVACLCHDLDHRALSNQFLQKTSHPLAQLYPTSTMEYHHINMMDIIGRKDCTV FEKLNSTEYERAVYVMKEAILATDLALYFGNRGQIEELLTQGDFDFDNQQHRTSAIGLMM TACDLSSSAKDWEVTRNNLLDLHFEFWDEGDQRKRLGIEPLLPMMDRDLEEDLAEGQVGF YSNVSIKCFESLARVLPSCEALAANGKENLERWRQ >Caenorhabditis elegans_(R08D7) MLELRRNSSPSSAHPSPQTNCQNSQRGDGLHHHHHEAASGSTCCGGMTVFTGANAAKSSN EPAGSASPTVWRKTSHPPLHFNNNETRNRNLQMQLKNRGTKDDWGASLRYDIEEPTSSGL LELLPDVPIVRKLSRPLVKMDDQDDACSVASNESDRTVLSPLVPMSIFDQFLCLTNNLSA LISCIIAEAKKNTEAEDYAVFLHDEDNKQMVLFNNETMLMTGKKFDMGYGIVGKVASTMR TMNIRDVSRCPFFNEEIDEQFSIKARNLIAFPLIDSSCSLIGVIVLYNKENGFSRHDEKY IKRFSYFVANSIAHAILAKQIEEVRTRIHMVEEFKIQGEDAVIEEVDIMRLVNDPLRDWR YFSQNFADFSFPPRSVGENHFHRASMMFFEDLGFSMLYKLNKRKLSYLVLRVSAGYRPVP YHNWSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQSLQK TPLSVLYSTEGSVLERHHFAQTIKLLQQEECSILENLPAADFRTIVNTIREVILATDISA HLRKQERIKTMISEGYNPMSFDHRYLLMCLVMTASDLSDQAKNFHNAKRIAENIYLEFFA QGDLELQLGVKPLEMMDRTNAYVPTVQIDFLFKIGVPVFQLLASVVPEGRTTSEAIDANH LCWVALDEEVRNNPSATNTLEYLRDENLERRIYDRVRKQDPRAAEIASKRFEPVYANGSV PQTQDILDHRFDGYDKKYQIGCSGGQNQSNGKQQQIRSLQKIRSKTSEDDALLKPMDNGG SVAASSTRRGSRTPRRLWRRARQLISSMSSSCASCSPLPSRRQVSEDSESC >Caenorhabditis elegans_(E01F3) MSPGPPAVGGVSPPVMVPGSAPPFQPTHQYFQHHYHQTPPGKLRDRSPRLSAEMRKNRDT ATSSPASSGVSIQQRRGSTTQNSGVGSIGLPVLGGRGRGVMSDGHMQRTFHEAMRQRRTS LPANSLSLNGAKVTGSSLSEAKGLIADMLMNKELPGNVASCLRAVTMLLEQRPLPLNGLL NDFGLPSVVENPYGGESMVVGASKPRISNITFSTVTSATGLPTVPAEPNKARSSSYWKTE ASPSNNNEHETPVDLLRKISVSRKESGTHVDTVVTTIDGQRYDTRELDTDPDLAETAVWS FPIFQMSRKHPQTILSRLTYNIFQQAELFRIFKVSPIKFFNFFHALEKGYWEIPYHNRIH AADVLHGCYYLSAHPVRSTFLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAM HDYDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKR FRYLVLEYILATDLKQHFEIIMTFTERLTEIDVQVETDRLLIGKLLIKMADINSPTKPYG LHRQWTDRICEEFYEQGDDERRRGLPITPYMDRGDAQVAKLQDSFIAHVVSPLATAMNEC GLLPILPGLDTSELIINMEHNHRKWKEQIELENGGSYEAQITCNGGTAVNGVIEEESAST SDSPDPRRDSPLDSDLSQVPFTICCSIAEEEYV >Caenorhabditis elegans_(C32E12) MDDASVLKYLQENPKLVEDFVVSNEISPETFKRWAVRRTMKYKNVKNGTSGGTGAWTEPD LSMKRRVILETSDNRTRILYEITQCCGQLIGTNSIELIVQNDEGAFSCRKTENGELKLKK VKTSKSADYIQTIVNAGNQTIAEIHFYTQLDSTEKSIVNAVCTWAAATNYYSELYTHKQE GSDGQDIHENIAKQRKLSNFLLDVARSIFHDIVSMDAVIIKVMNFAQKLVDADRASLFLV DSKNAQIYARIFDVGTGDEEHVRVNSEGQKEIRFDMSKGIAGYVASTGEGLNIENAYEDE RFNADVDSKTGYTTKTILCMPILIRGIVIGVVQMVNKHDGVFTRQDEDAFEIFAVYCGLA LHHAKLYDKIRRSEQKYRVALEVLAYHSVCNADEVNKLKKIEINNRIVELETIDFNGMRL SELEKPLYAVYMFKTLFADTLRFDTEDLIRFVLTVRKNYRRVAYHNWAHGWSVAHAMFAT LMNSPDAFTKLEALALYVSCLCHDLDHRGKNNAYMKTMSTPLASIYSTSVMERHHFNQTV TILQQDGHNILKSLSSEDYKKTLSLIKHCILATDLALFFSNKAKLNVILDNNTFDINRQE HRLLTQAVMMTGCDLVASAKPWNIQTETVKVIFEEFYDQGDAERLSGKEPIPMMDRQQAH MLPQMQVGFMRGICMPCYDLIARIFPKNDKMRERCEYNAKKWEELAEEQRKKQEALAQQN GEANETQE >Caenorhabditis elegans_(E01F3) MSPGPPAVGGVSPPVMVPGSAPPFQPTHQYFQHHYHQTPPGKLRDRSPRLSAEMRKNRDT ATSSPASSGVSIQQRRGSTTQNSGVGSIGLPVLGGRGRGVMSDGHMQRTFHEAMRQRRTS LPANSLSLNGAKVTGSSLSEAKGLIADMLMNKELPGNVASCLRAVTMLLEQRPLPLNGLL NDFGLPSVVENPYGGESMVVGASKPRISNITFSTVTSATGLPTVPAEPNKARSSSYWKTE ASPSNNNEHETPVDLLRKISVSRKESGTHVDTVVTTIDGQRYDTRELDTDPDLAETAVWS FPIFQMSRKHPQTILSRLTYNIFQQAELFRIFKVSPIKFFNFFHALEKGYWEIPYHNRIH AADVLHGCYYLSAHPVRSTFLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMALFTAAAM HDYDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKR FRYLVLEYILATDLKQHFEIIMTFTERLTEIDVQVETDRLLIGKLLIKMADINSPTKPYG LHRQWTDRICEEFYEQGDDERRRGLPITPYMDRGDAQVAKLQDSFIAHVVSPLATAMNEC GLLPILPGLDTSELIINMEHNHRKWKEQIELENGGSYEAQITCNGGTAVNGVIEEESAST SDSPDPRRDSPLDSDLSQVPFTICCSIAEEEYV >Nematostella vectensis_(XP_001636689) MCHRKTSSSVRIQQGTTIAAYVAYTLKPVRTTDILGDERFPQGTGVDSKCTTAQSILCQPIVQSNGELVG TIELSRMVGRDPFDEEDEEVFNSYLVWGGISLYYAEMYLHMHKHRKLTEFLLNVTRSIFQDIVSMDTVIM KIMNYAQTLVDADRTSLFLVDNKTNELYARIFDIGGSLEDSRSSQLQKEIRFPKTKGVAGYVATSGETLN ISDAYHDDRFNREIDIQTGYTTRTLLCMPIFIRGNIIGVVQMVNKKSGVLIMCFSSDEKSFQTFAIYCGL ALHHAKLYDKIRRSEQKHRVALEVLSYHSKCSEGELHRLKELDCPDPYPDLETYEFDSYSLDSEVMPKLV IFQTRNLFSLSRFDLDELYRFVLTVRKNYRKVPYHNWTHAFAVAHCMYLVIRSGHNNFTGLEALAMFFAC LCHDLDHRGRTNSWMKNEGTPLAAVYSTSTMEHHHFNQTITILQHEGHNIFSQLNSAEYKTVLGYMKECI LATDLALFFGNKAKLKDVVDKGTFSWDDQEHRRLLRAICMTACDLSACTKPWRIQYKIVEVIYQEFYAEG DLEKAQGKQPIPMKDRNTAHELPAHQVGFLVGICLPCYELLGKVIPGTKPLVDGGK >Nematostella vectensis_(XP_001635720) MGLNKESKLDLKNSNEREFFFEIVRDIANDLDLKTLSYKILVNVGILTNADRCSLFLVEGPKGKQWLVSK VFDVHIGSLNVSSAKEAIDHQREIRVPLGVGLVGYAAETGETVNIPDAYADPRFNQDVDKQTGYHTKSLL CKPVKNNEGEVVGVAQIINKNPGGVPFTKEDEKVCDMYLTFCGIGITNAKLFELSAIEFNRNRALLELVH DIFEEQTSLEKVVHKIMKRALGLLKCEKCSVLLLTQPELRFSRVFNLKTTGRITSNTRYGFILLLVSEGH NDRSFTSRVAKLVAATGKTMNIPDASQDTRLADSSNVEKKGFSPILCMPIRNNKFEIIGVAELINRLDNK PFDENDETLFEAFAIFCGLGIHNTMIYDQMARAKAKQQVALEVLSYHVAAKKTEVEKIRDTQVPKAVDIN LHSFKFDDFSLAADDMLIASLRMFKDCGFIEEFHIDYEVLSRWILTVKNNYRNVIYHNWRHAFNVAQSMF CMLTTGGMASVITKLECLGLIVGCLCHDLDHRGTNNAFQAKTDSPLSKLYGTSTLEHHHFNHAVIILSTE GFSPILSDEYRQVISYIKHSILSTDLATNFKQRPKFFALVESGEFDPYNMDHRDMLKAMMMTACDLNGTT KPWEIQKEVVNLVTREFFEQGDMERERYNMEPMAIMDRQKIDELPKLQVQFFETTGLPVFKVLAKLNNKL QPLVDGAESNKRRWQKLDAERGLAS >Nematostella vectensis_(XP_001631585) MINLEDASTEQKVESWLDEHPEFVQSYFARKANRSLVDSWLHSRSHARTPSGTPPPSGSSTPVRKISASE FEGRGILKPLVNVVDGQLSFLSPSEPSRKRSTAHRNRKSRLELQQLDEKEVLMELVKDISNDLDVQSLCH KILQNVSILLNADRCSLFLCQGPKEGPRFLVSKVFDVNAESKLEDVQCLEEIRIPWGTGIVGYVAETGET VNIPNAYEDARFNKEIDKKTGYTTRSILCMPIKDHDGEVIGVAQVINKTGKSTDSAFTIDDEQIFLKYLV FCGIGINNAELYERAQLEIRRNQVLLDLARTIFEEQTSLHNIVHKIMMITQSLLQCERCSVLLVDPTSKT LFAQAFDLEAKDYLQNDDDDKTVEVRFPINIGITGHVATTGETLNIPDAYADERFDPTVDQVSGFTTKTI LCMPIKNASGDIIGVVQLLNKVDGTPFNKNDENLFEAFAIFCGMAIHSTVMYENVNKAMAKRKVALEVLS YHAVSPLEEAIKLKEEPLPPITSLRLIDFAFDDMSISDDDTLKGCLAMLCDLKIVETFQIDYLTLCRFVL TIKKNYRPVMYHNWRHAFNVAQTMYAMLKKPSIGKYFTVIEQYALIVACLSHDLDHRGTNNSFQIKSATP LAQLYSTSTMEHHHFDQCIMIINSQGNEIFNTLSADEYNKIIKLLEASIIATDLALYFQRRGDFFKKVEN RELDWSDDSSKDLLRAMMMTACDLSAITKPWLVQKRTAHLVAEEFFQQGDLEQEELHSTPLPTMDRRKKD ELPQMQVGFIDAVCLPLYKAFSQFDDNLKVLKDGCRENRRQWQKLAEDHKAREVSCRTRV