>Homo sapiens_SP4(ENSP_222584)
MATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPS
QGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASP
TKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQ
LISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTL
PINIGGVTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPES
PSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESEAQSSSQ
LQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQ
QQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTIT
PVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITS
VAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPG
KRLRRVACSCPNCREGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPF
ICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGT
ALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF

>Mus musculus_SP4(ENSMUSP_26367)
VADQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPG
ENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPAS
SSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGSVQYQVIPQLQTVEGQPIQIN
PTSSSSLHDSQGQIQLISAVPLQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALP
VINNVTAGGGTGQVGQPTTTTDSGTSNGNQLVSTPTTSTAPASTMPESPSSSTTCTTTAS
TTLTSSDTLVSSADTGQYASTSASSSERTIEEPQTPAATESEAQSSSQLQSNGIQNAQDQ
SNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAV
NPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQ
IAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVK
VQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVACSCPN
CREGEGRGSSEPGKKKQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFT
RSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDS
SVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF

>Rattus norvegicus_SP4(ENSRNOP_7625)
MSDQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPG
ENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPAS
SSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQIN
PTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQ
LQTLPGTQAQVVTTLPINIGGVTLALPVINNVTAGGGTGQVGQPTTTTTDSGTSNGNQLV
STPTTSTAPASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEE
PQTPAATESEAQSSSQLQSNGIQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIP
PQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLS
NLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANL
GAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQV
HLQQGQQTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKKKQHVCHIEGCGKVYGKT
SHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDH
LSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNM
EEF

>Gallus gallus_SP4(ENSGALP_17715)
FADQKKEETMPTEGEKSPEAENNNNNNKKGKTGGSQDSQPSPLALLAATCSKIGTPGENQ
ATGQQQIIIDPNQGLVQLQNQPQQLELVTTQLAGNSWQLVAASPSASKDNNVAQQGSSVA
SSAPSPSSSNNGSASPTKTKSGNSSATTPGQFQVIQVQNPSGSVQYQVIPQIQTTEGQQI
QINPANATGLQDIQGQIQLIPAGNNQAILTASNRTASGNIIAQNLANQTVPVQIRPGVSI
PLQLQTIPGTQAQVVTTLPINIGGVTLALPVINNMAAGGGSGQVGQSTEGGVSNGSQLAS
TPVTSASVSSMPDSPSSSSTSTTTASTSLTSSDTLVSSAETGQYTSTAGSSSEQPTEESQ
TTATDSEAQSSSQLQSNGLQNVQDQSGSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQS
FQLQSGQTIQTIQQQSLQNVQLQAVSPTQVLIRAPTLTPSGQISWQTVQVQNLQSLSNLQ
VQNAGLPQQLTITPVSSSGGTTIAQIAPVAVAGTPITLNAAQLASVPNLQTVSVANLGAA
GVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANAGIGAVSPDQITQVQLQ
QAQQASDQEVQPGKRTRRVACSCPNCREGEGRSSNEPGKKKQHICHIEGCGKVYGKTSHL
RAHLRWHTGERPFICNWVFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSK
HVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF

>Xenopus tropicalis_SP4(ENSXETP_16169)
MASEGGKASESENKKKGKASGSQDSQPSPLALLAATCSKIGTTGENQGAGQQQIIIDPSQ
GLVQLQNQPQQLELVTTQLAGSAWQIVAAAPPVSKENNITQQGVAIAASTAASSSINSEN
ASPTKSKPSNAATAPGQFQVIQVQTPGGNVQYQVIPQIQTVEGQHIQISPGNTTALQDLQ
GQIQFIPAGNNQAIITAGNRTASGNIIAQNLANQTVPVQIRPGVSIPLQLQTIPGAPAQV
VTTLPINIGGVTLALPVINSMPAGGGSAQIVQPTDGGVSNGNQLLSTPITTSSVSTMPES
PSSSSSSTCTTTVSATLTSSDTLVSSAETNQYTSTSASAERNTEESPSSVTDGEAQSSNQ
LQSNGLQNMSEQSNSLQQVQIVGQPVLQQIQIQQPQQQIIQAIPQQSFQLQSGQTIQTLQ
QQQLQNVQLQALSPTQVLIRAPTLTPSGQISWQTVQVQNIQSLQNLQVQNPGLPQQLTLT
PVSTSSGTTIAQIAPVTVAGTPITLNAAHFTSVPNLQTVSVANLGAAGVQVQGVPVTITS
VGGQQQGAEGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVQLQQSQPSSDQEVQTG
KRLRRVACSCPNCREGEGRGNSEPGKKKQHICHIENCGKVYGKTSHLRAHLRWHTGERPF
VCNWIFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGT
ALAIVTSGDLDSSVTGVLGSPRIVTVAAISQDSNPATPNVSTNIDEF

>Danio rerio_SP4(ENSDARP_88299)
MSDQKKEAMATDGGKASGGDGGTKGKTSGSQDAQPSPLALLAATCSKIGGVGAEGQAAAQ
QQIIIDPNQGLLQLQNPTQQLELVPAQLTGNGWQIIATSPATATKDSIQQAGANAASSEA
AAGRKVKAVGSNNAAQQQFQIIQVQNLPNSSGGIQYQVIPHLQTADGQQIQISPSNPAAL
SVQPEQIQLISTGNNQAILATPQRTGSASIVQNQTIPLQIRPSFPLQLQTIQGTQAPMVT
TLPINLGGVTLALPVINNVAGAGGSVQLLQSSDGSISNGNQLITTVTTSTADSTGSSTST
TTATGSDSVVVTSADGLSTTSMVSAESPKDNEADLTQSNGLQSTSEQAGQIQQFQIVGHP
VLQQIQIQSPQQQVVQGSIQIQPGQTLQPVQQNLQLQAFQNPAQVLIRTPTLTPSGQISW
QTVQVQNAGMPQQLTLAPVASSAGGGTFAQIAPLTLGGSPITLSAAQLPAGSGVQTVNIA
GLGAAGVQVQGVPLTITGVQGQQQGQDGVKVQSAPVTVTVGNISNAVSPEQMGQVQSPSD
QEGQPSKRLRRVACSCPNCRDGEGRNNSDPSKKKQHVCHMEGCGKVYGKTSHLRAHLRWH
TGERPFVCNWIFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHIKTHQN
KKGGAALTIITTDEMEEEVDEVLGSPRIVTVATLSHDSNPATPTTSNNLEEEFE

>Takifugu rubripes_SP4(ENSTRUP_20555)
SQPSPLALLAATCSKIGGQGGAEVAQAGAQPIQVQAGQIQLQAGQLQGQIVVDTAGGQAL
VPQQLELVPAQFTGNGWQIITTAPTMAKETSNQPVAVTVATTLANDSSPGGRKVKPVGGT
NSSPATQQQFQIIQVQNLPSAGSGVQYQVIPHLQTADGQQIHISPAQTAPIGALPEQVQL
IQTQSPSQTQAILQPANQQAILTSSANQTVPLQIRPAQSFPLQLQTLQGSQAPVMTTVPI
NIGGMTLALPVINNVGGAGAVQLIQAADGTLSVANGNQLVTTAVPGPAPGTASSGSTAVA
DGDSASDGTQMVSVGTEGAQADAQVQSSEADSQTQNQANGLQSQTDATGTVQQVIVGQVG
HQFVQQIQLQPQAQSPGQVQGQQQPQHIQTLQLAPGQTLQPIQAFQNPAQVLIRTPTLSP
SGQLTWQTLQLPSSVSLQSGLGAAVPQQLTLAPVAGGTPMGGGGLVSLSGAPLTLSAAQI
NPGSGVQTVSIAGLGAAGVQVQGVPLTITGIQGQPQGQDGVKVQSSPVTVAVGNVASGSS
MSPEQLGSVQSSSEQDGPPNKRLRRVACSCPNCRDGEGRNSGDPTKKKQHICHMEGCGKV
YGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGGEQQPCKGARFFYS
GIFFLARILCLCPREKSASSVRSAQSASCAATTSPSTSRPTRTRRVELRWQSSPLKTWRK
TLPKAWARPLTLSPWRLSRVTLTLLRPPPLITWRKRRRTTRSLSRR

>Tetraodon nigroviridis_SP4(ENSTNIP_5472)
SQPSPLALLAATCSKIGGQGGAEGAQAGAQQIQVQAGPIQLQAGQLQGQIVVDAAGGQAL
VPQQLELVPAQFTGNGWQIITTAPTMAKETSNQPVAVTVATTLANDSSPGGRKAKEVGPA
AQQQQQQQQFQIIQVQNLPSAGSGVQYQVIPHLQTADGQQIHISPAQTAPIGALPEQVQL
IQTQSPSQTQAILQPASQQAILTSTANQTVPLQIRPAQSFPLQLQTLQGSQAPVMTTVPI
NIGGMTLALPVINNVAGAGAVQLIQSADGTFSVANGNQLVTTALPGPAPASSGSTAVAEG
DGVSDGTQMVSVGAEGAQGDGQVQSGEADSQTQNQANGVQNQPDGTGTVQQVIVGQVGHQ
LVQQIQLQPQAQSPGQAQGQQQPQHIQTLQLAPGQTLQPIQAFQNPAQVLIRTPTLSPSG
QITWQTLQLPSGVSLQGGLGAAVPQQLTLAPVASGTPVGSGGLVSLSGAPLTLSAAQINP
GSGVQTVSIAGLGAAGVQVQGVPLTITGLQGQPQGQDGVKVQSSPVTVAVGNVASGSSMS
PEQLGSVQSSSEQDGPPNKRLRRVACSCPNCRDGEGRNSGDPTKKKQHICHMEGCGKVYG
KTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGGKPLDTRGRTPGRAFF
SRVLFLFPSSQGKSASSVRSAPSASCAATTSPSTSKPTRTRRAEPRWQSSPPKTWRRTPP
KAWARPLTSSPWRLSPATLTPRRPPPLITWRKRRTRTRSLSRRRTLLFTES>Homo sapiens SP1
MSDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGGGGQESQPSP
LALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTS
KEQSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGVMPNIQYQVIPQFQ
TVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQG
LANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAVTISSSGSQESGSQPVT
SGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNSQGQTPQRVS
GLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPL
SGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQ
TITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTS
GIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQPQAGRRTR
REACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTW
SYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALS
VGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVADLQSINI
SGNGF

>Mus musculus Sp1
MSDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQP
SPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTAAQLSQGANGWQIISSSSGATP
TSKEQSGNSTNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQFQT
VDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIIPNRGSGGNIIAAMPNLLQQAVPLQGL
ANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESSSQPVTS
GTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTPQRVGG
LQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAPLS
GQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQT
ITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSG
IQVHQLPGLPLAIANTPGDHGTQLGLHGSGGDGIHDETAGGEGENSSDLQPQAGRRTRRE
ACTCPYCKDSEGRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSY
CGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVG
TLPLDSGAGSEGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNG
F

>Rattus norvegicus Sp1
FLDQDHSMDEVTAVKIEKGVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGGGGGQESQPS
PLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLSQGANGWQIISSSSGATPT
SKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGLPGVMPNIQYQVIPQF
QTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGNIIAAMPNLLQQAVPLQ
GLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTISSSGSQESGSQPV
TSGTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSSGTSSQGQTSQRV
GGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQALQALQAAP
LSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQA
QTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGT
SGIQVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHDETAGGEEGENSPDPQPQAGRRT
RREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCN
WSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVAL
SVGTLPLDSGAGSEGSGTATPSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSIN
ISGNGF

>Xenopus tropicalis Sp1
MSDQEHTSDDMPTIKSENRTGGGYIQKGQDSQPSPLALLAATCSRIEPPENGNGNSQQQG
ATELDLSTAQLAQTANGWQIISTAGSASKDQAGGDASSKNRPIAPGQFVVSTPSVQNQQV
LASLQGVMPNIQYQVIPQFQTVDGQQLQFTTAPAQVSVQQDASGQFQIIPATNQQIITTN
RTGTGNILAMPNLLQQAVPIQGMGLTNNVLSGQTQYLTNVPVALNGNITLLPVNAASLTP
TSQSVTLSGTQENNSQPVTSGVAISSSQLASQANSGAYFTNANSFSTTTTPSNVSLMNCS
SAGSTPGSNVQVQTSQRSTGQLSLLTDSVQQGNGNMQKDGDQNQQQQILIQPQIVQSGQT
IQALQAAQLSGQAFSTQAISQDALQNLQIQTVPNTGPIIIRTPAVGPNGQVTWQTIQLQN
LQVQNPQAQTITLAPMQGVSLGQSGSTNTLTSMPAGTVTVNAAQLSSMPGLQTINLGALG
ASGIQVHQLQGVPLTITNATGDIASGTIR

>Gallus gallus Sp1
MSDSESPEEMAAVKGTPERGEGDGSSDSSSPAGEGQESQPSPLALLAATCSRIESPNENS
NSSQGQQGGSGELDLTAAAAQIAQSANGWQIISTGSTTPTPSKEQGSNGSNGDPSKSRPV
STGPYVVTAASNLQNQQVLTGLPGVIPNIQYQVIPQFQTIDGQQLQFATTPAQVNVQQDA
SGQLQIIPGTNQQIITSRAGTGNLIAMPNLLQQAVPIQGVGLANNTLSGQTQYVANVPVA
LNGNITLLPVNSVAASLAPTSQTVTLSGSGSPDSSSQPTTSGAAISSSNIATSHASSGSF
FTNANSYSTTTTTSNMGIMNFSSSSTVGTNVQVQTPQRAPSTDSLQSQVSGVALQPGQQK
EGDQSQQSQQQQQQILIQPQLVQGGQTIQALQTAPLSGQTFATQAISQDALQNLQLQAVP
NSGPIIIRTPTVGPNGQVSWQTIQLQNLQVQNPQAQTITLAPMQGVSLGQTGSTSTTLTP
IASLPSGTVTVNAAQLSSMPGLQTINLSALGASGIQVHQLQGLPLAIANATGEHGTQLGL
HGASGDGLGDDSAAVEEGETSPDPQPQQGRKVRREACTCPYCKDSEGRSSGDPGKKKQHI
CHIPGCGKVYGKTSHLRAHLRWHTGERPFICGWMLCGKRFTRSDELQRHKRTHTGEKKFA
CPECPKRFMRSDHLSKHIKTHQNKKGGAANSVAMNVSAVPMDTGASSEGSGGPTPSALIA
TNMVAMEAICPDGIARLASSGINVMQVADLQSINISGNGF

>Tetraodon nigroviridis SP1
MSWLRLHQCQGEQVLTTISGVMPNIQYQVIPSFQTVDGQPLQLAHAQQESAGPAAAAPGQ
QFQIVSSPNGQQIIAATNRAGAAGNIITMPSLLQGAIPIQNISLGNSVLKNQPQFLANMP
VSLNGNITLLPISTAASSGTAGDANGGDTARNPITQQQPASSNSATGYATSVSTAQTSTS
YGLTQTQNSNGVMTGTFQQNAATLGVPIQPENREGQQPQQILIQPQQVLPGGATLQGIQA
GTVATAGGQVFAAPTISQEGLQNLQIMPNAGPILLHTVGPNGQVSWQTIQIQNPAGPQIT
LAPVQTLPQLGQGQGAAAASGVSVNAVQIPGIQTINLNTLGGSGLQLQTVPLTLANAAGE
KRFACPECPKRFMRSDHLSKHIKTHMNKKVQAASASGPAGSTDSSSPAIVGTKVETGAAA
TADQHTIVTMETLSAESIARLASSGINMMQVDLHQMNGNNY

>Takifugu rubripes SP1
QPSPLALLAATCSRIDTPGESDSPSDQQNQQQQLELNQGAFTSNSNGWQVIPLNIQASSG
ANTATTDSSAVMAGGDAGKSRQLLSPSVAVGSTQGQQHQPQQYVVAQAPSMPGQQVLTTI
SGVMPNIQYQVIPQFQTIDGQPLQLAHAQQESAVPAAAAPGQQFQIVSSPNGQQLIAATN
RAGTAGNIITMPSLIQGAIPIQNISLGNGMLKNQPQFLANMPVSLNGNITLLPISTATGG
TGADTNGGDTARNQVTQQQQPVSSTGSTGYVTSVSTAQTATSYGLTQTQNSNGVMTFQQN
TANLGVPIQPESREGQPQQQILIQPQQVIQGGATLQPIQAGTVATAGGQVFAAPTISQEG
LQNLQIMPNTGSILLHTVGPNGQVSWQTIQIQNPAGPQITLAPMQTLPQLGQAQGAAAAA
GVSVNAVQIPGIQTINLNTLGGSGLQLQTVPITLANTAGDHQNLHSGGDTLDDGTAIDEG
DMSPPPQGRRNRREACTCPFCKDGEGRDPTKKKQHICHISGCGKIYGKTSHLRAHLRWHT
GERPFVCSWSFCGKRFTRSDELQRHKRTHTGEKRFACPECPKRFMRSDHLSKHIKTHTNK
KVPAASASGIAGSSDPTAVGTKVEQGAGAASDQHTIVTMETLSAESIARLASSGLNMMQV
DLHPMN

>Homo sapiens SP4
MATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPS
QGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASP
TKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQ
LISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTL
PINIGGVTLALPVINNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPES
PSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEESQTPAATESEAQSSSQ
LQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQ
QQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTIT
PVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITS
VAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDQEVQPG
KRLRRVACSCPNCREGEGRGSNEPGKKKQHICHIEGCGKVYGKTSHLRAHLRWHTGERPF
ICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGT
ALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF

>Mus musculus SP4
VADQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPG
ENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPAS
SSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGSVQYQVIPQLQTVEGQPIQIN
PTSSSSLHDSQGQIQLISAVPLQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALP
VINNVTAGGGTGQVGQPTTTTDSGTSNGNQLVSTPTTSTAPASTMPESPSSSTTCTTTAS
TTLTSSDTLVSSADTGQYASTSASSSERTIEEPQTPAATESEAQSSSQLQSNGIQNAQDQ
SNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAV
NPTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQ
IAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDGVK
VQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVACSCPN
CREGEGRGSSEPGKKKQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMFCGKRFT
RSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAIVTSGELDS
SVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF

> Rattus norvegicus SP4
MSDQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPG
ENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQLVASTPPASKENNVSQPAS
SSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQIN
PTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQ
LQTLPGTQAQVVTTLPINIGGVTLALPVINNVTAGGGTGQVGQPTTTTTDSGTSNGNQLV
STPTTSTAPASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIEE
PQTPAATESEAQSSSQLQSNGIQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIP
PQSFQLQSGQTIQTIQQQPLQNVQLQAVNPTQVLIRAPTLTPSGQISWQTVQVQNIQSLS
NLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVANL
GAAGVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQV
HLQQGQQTSDAEVQPGKRLRRVACSCPNCREGEGRGSSEPGKKKQHVCHIEGCGKVYGKT
SHLRAHLRWHTGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDH
LSKHVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNM
EEF

>Xenopus tropicalis Sp4
MASEGGKASESENKKKGKASGSQDSQPSPLALLAATCSKIGTTGENQGAGQQQIIIDPSQ
GLVQLQNQPQQLELVTTQLAGSAWQIVAAAPPVSKENNITQQGVAIAASTAASSSINSEN
ASPTKSKPSNAATAPGQFQVIQVQTPGGNVQYQVIPQIQTVEGQHIQISPGNTTALQDLQ
GQIQFIPAGNNQAIITAGNRTASGNIIAQNLANQTVPVQIRPGVSIPLQLQTIPGAPAQV
VTTLPINIGGVTLALPVINSMPAGGGSAQIVQPTDGGVSNGNQLLSTPITTSSVSTMPES
PSSSSSSTCTTTVSATLTSSDTLVSSAETNQYTSTSASAERNTEESPSSVTDGEAQSSNQ
LQSNGLQNMSEQSNSLQQVQIVGQPVLQQIQIQQPQQQIIQAIPQQSFQLQSGQTIQTLQ
QQQLQNVQLQALSPTQVLIRAPTLTPSGQISWQTVQVQNIQSLQNLQVQNPGLPQQLTLT
PVSTSSGTTIAQIAPVTVAGTPITLNAAHFTSVPNLQTVSVANLGAAGVQVQGVPVTITS
VGGQQQGAEGVKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVQLQQSQPSSDQEVQTG
KRLRRVACSCPNCREGEGRGNSEPGKKKQHICHIENCGKVYGKTSHLRAHLRWHTGERPF
VCNWIFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGT
ALAIVTSGDLDSSVTGVLGSPRIVTVAAISQDSNPATPNVSTNIDEF

>Gallus gallus Sp4
FADQKKEETMPTEGEKSPEAENNNNNNKKGKTGGSQDSQPSPLALLAATCSKIGTPGENQ
ATGQQQIIIDPNQGLVQLQNQPQQLELVTTQLAGNSWQLVAASPSASKDNNVAQQGSSVA
SSAPSPSSSNNGSASPTKTKSGNSSATTPGQFQVIQVQNPSGSVQYQVIPQIQTTEGQQI
QINPANATGLQDIQGQIQLIPAGNNQAILTASNRTASGNIIAQNLANQTVPVQIRPGVSI
PLQLQTIPGTQAQVVTTLPINIGGVTLALPVINNMAAGGGSGQVGQSTEGGVSNGSQLAS
TPVTSASVSSMPDSPSSSSTSTTTASTSLTSSDTLVSSAETGQYTSTAGSSSEQPTEESQ
TTATDSEAQSSSQLQSNGLQNVQDQSGSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQS
FQLQSGQTIQTIQQQSLQNVQLQAVSPTQVLIRAPTLTPSGQISWQTVQVQNLQSLSNLQ
VQNAGLPQQLTITPVSSSGGTTIAQIAPVAVAGTPITLNAAQLASVPNLQTVSVANLGAA
GVQVQGVPVTITSVAGQQQGQDGVKVQQATIAPVTVAVGGIANAGIGAVSPDQITQVQLQ
QAQQASDQEVQPGKRTRRVACSCPNCREGEGRSSNEPGKKKQHICHIEGCGKVYGKTSHL
RAHLRWHTGERPFICNWVFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSK
HVKTHQNKKGGGTALAIVTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF

>Tetraodon nigroviridis SP4
SQPSPLALLAATCSKIGGQGGAEGAQAGAQQIQVQAGPIQLQAGQLQGQIVVDAAGGQAL
VPQQLELVPAQFTGNGWQIITTAPTMAKETSNQPVAVTVATTLANDSSPGGRKAKEVGPA
AQQQQQQQQFQIIQVQNLPSAGSGVQYQVIPHLQTADGQQIHISPAQTAPIGALPEQVQL
IQTQSPSQTQAILQPASQQAILTSTANQTVPLQIRPAQSFPLQLQTLQGSQAPVMTTVPI
NIGGMTLALPVINNVAGAGAVQLIQSADGTFSVANGNQLVTTALPGPAPASSGSTAVAEG
DGVSDGTQMVSVGAEGAQGDGQVQSGEADSQTQNQANGVQNQPDGTGTVQQVIVGQVGHQ
LVQQIQLQPQAQSPGQAQGQQQPQHIQTLQLAPGQTLQPIQAFQNPAQVLIRTPTLSPSG
QITWQTLQLPSGVSLQGGLGAAVPQQLTLAPVASGTPVGSGGLVSLSGAPLTLSAAQINP
GSGVQTVSIAGLGAAGVQVQGVPLTITGLQGQPQGQDGVKVQSSPVTVAVGNVASGSSMS
PEQLGSVQSSSEQDGPPNKRLRRVACSCPNCRDGEGRNSGDPTKKKQHICHMEGCGKVYG
KTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGGKPLDTRGRTPGRAFF
SRVLFLFPSSQGKSASSVRSAPSASCAATTSPSTSKPTRTRRAEPRWQSSPPKTWRRTPP
KAWARPLTSSPWRLSPATLTPRRPPPLITWRKRRTRTRSLSRRRTLLFTES

>Takifugu rubripes SP4
SQPSPLALLAATCSKIGGQGGAEVAQAGAQPIQVQAGQIQLQAGQLQGQIVVDTAGGQAL
VPQQLELVPAQFTGNGWQIITTAPTMAKETSNQPVAVTVATTLANDSSPGGRKVKPVGGT
NSSPATQQQFQIIQVQNLPSAGSGVQYQVIPHLQTADGQQIHISPAQTAPIGALPEQVQL
IQTQSPSQTQAILQPANQQAILTSSANQTVPLQIRPAQSFPLQLQTLQGSQAPVMTTVPI
NIGGMTLALPVINNVGGAGAVQLIQAADGTLSVANGNQLVTTAVPGPAPGTASSGSTAVA
DGDSASDGTQMVSVGTEGAQADAQVQSSEADSQTQNQANGLQSQTDATGTVQQVIVGQVG
HQFVQQIQLQPQAQSPGQVQGQQQPQHIQTLQLAPGQTLQPIQAFQNPAQVLIRTPTLSP
SGQLTWQTLQLPSSVSLQSGLGAAVPQQLTLAPVAGGTPMGGGGLVSLSGAPLTLSAAQI
NPGSGVQTVSIAGLGAAGVQVQGVPLTITGIQGQPQGQDGVKVQSSPVTVAVGNVASGSS
MSPEQLGSVQSSSEQDGPPNKRLRRVACSCPNCRDGEGRNSGDPTKKKQHICHMEGCGKV
YGKTSHLRAHLRWHTGERPFVCNWIFCGKRFTRSDELQRHRRTHTGGEQQPCKGARFFYS
GIFFLARILCLCPREKSASSVRSAQSASCAATTSPSTSRPTRTRRVELRWQSSPLKTWRK
TLPKAWARPLTLSPWRLSRVTLTLLRPPPLITWRKRRRTTRSLSRR

>Danio rerio Sp4 
MSDQKKEAMATDGGKASGGDGGTKGKTSGSQDAQPSPLALLAATCSKIGGVGAEGQAAAQ
QQIIIDPNQGLLQLQNPTQQLELVPAQLTGNGWQIIATSPATATKDSIQQAGANAASSEA
AAGRKVKAVGSNNAAQQQFQIIQVQNLPNSSGGIQYQVIPHLQTADGQQIQISPSNPAAL
SVQPEQIQLISTGNNQAILATPQRTGSASIVQNQTIPLQIRPSFPLQLQTIQGTQAPMVT
TLPINLGGVTLALPVINNVAGAGGSVQLLQSSDGSISNGNQLITTVTTSTADSTGSSTST
TTATGSDSVVVTSADGLSTTSMVSAESPKDNEADLTQSNGLQSTSEQAGQIQQFQIVGHP
VLQQIQIQSPQQQVVQGSIQIQPGQTLQPVQQNLQLQAFQNPAQVLIRTPTLTPSGQISW
QTVQVQNAGMPQQLTLAPVASSAGGGTFAQIAPLTLGGSPITLSAAQLPAGSGVQTVNIA
GLGAAGVQVQGVPLTITGVQGQQQGQDGVKVQSAPVTVTVGNISNAVSPEQMGQVQSPSD
QEGQPSKRLRRVACSCPNCRDGEGRNNSDPSKKKQHVCHMEGCGKVYGKTSHLRAHLRWH
TGERPFVCNWIFCGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHIKTHQN
KKGGAALTIITTDEMEEEVDEVLGSPRIVTVATLSHDSNPATPTTSNNLEEEFE

>Homo sapiens SP3
MTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLA
LLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIK
DEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVIPQIQSAD
GQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVA
IGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTG
QAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSS
GQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQT
IHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQ
NTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGE
NADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVAC
TCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGK
RFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVE
AARDDTLITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNETM
E

>Mus musculus Sp3
MTAPEKPVKQEEMAALDVDGGGGGGGHGEYLQQQQQQQQQHGNGAAAAAAQDTQPSPLAL
LAATCSKIGPPSPGDDDEEAAVAAAAGVPAAAAGATGDLASAQLGGAPNRWEVLSATPTT
IKDEAGNLVQIPGAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQS
TDAQQVQIGFTGSSDNGGINQENSQIQIIPGSNQTLLASGTPPANIQNLIPQTGQVQVQG
VAIGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLIN
TGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTT
TSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQDSQQPTSQAQIVQGITP
QTIHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQ
IQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQLHP
GENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRV
ACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFC
GKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSSSTVLAS
VEAGRDDALITAGGTTLILANIQQGSVSGIGTVNTSATSNQDILTNTEIPLQLVTVSGNE
TME

> Rattus norvegicus Sp3
AAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPGAATSSGQYVLPLQNLQ
NQQIFSVAPGSDSSNGTVSNVQYQVIPQIQSTDAQQVQIGFTGSSDNGGINQESSQIQII
PGSNQTLLASGTPPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFV
PINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADT
DLFVPTSSSSQLPVTIDSTGILQQNTNSLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQ
VSTAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQLNPGT
FLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALT
STPVSLSTGQLPNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDRKSQLSGDSTL
NTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGC
GKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSK
RFMRSDHLAKHIKTHQNKKVIHSSSTVLASVEAGRDDALITAGGTTLILANIQQGSVSGI
GTVNASATSNQDILTNTEIPLQLVTVSGNETME

>Xenopus tropicalis Sp3
LAAPEQPVKREEMAAMEVDGQSEYLQQHGDSSSAGDDSDQGGGGGQTEDLAVQISGGPNR
WEVLTPAQAALKDEAGNIVQIPGGATVTSSGQYVLPIQTLQNQHLFSVAPGSDTANGTLS
NVQYQVIPQLQTSDGQQVQLGFTTSSDNGGLDQDGGQIQIIPGNHSGSLLSSSPNILTQA
GQIQHSGGSVQIQGVTIGGTSYAGQTQVVANVPIGLPGNITFVPINSVDLDSLGLTGSTE
AMTAGLTADGHLISGHGMENSENSERTAEHEHISPDGVDTNSDTDLFVPTSSSSQLPVTI
DGTGMLQQNANSLTDSPSGHVQTSDLHGNYIQTSMTDESQNIQVSASQTMVQQIHLQDSQ
PTSQAQLVQSIAQQAIQAVQGGTQGLSSQALQNLQLQLNPGTFLIQAQTVTPSGQIAWQT
FQVQGVQNLQNLQIPNSSAQQITLTPVQTLTLGQVAGGGTPVSLNAGQLPNLQTVTVNSV
DAAGIHLHHGDNSDSPTEIETHQTRQHFSSLQLSNFGIRIKEEEPDPDEWQLAGDSTVNT
NDLTHLRVQVVDDELDQPNQEGKRLRRVACTCPNCKDGAGRGTNLGKKKQHICHIPGCGK
VYGKTSHLRAHLRWHSGERPFVCTWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRF
MRSDHLAKHIKTH

>Gallus gallus Sp3
MQLMNHSQTGDLASVQLAGTPNRWEVLSAAPATIKDEAGNIVQIPGAATVTSSGQYVLPI
QSLQNQQIFSVAPGSDSSNGTVSNVQYQVIPQIQTADGQQVQLGFAASSDNSSINQETGQ
IQIIPGSNQTIIASGSPSANIQNILSQSGQVQVQGVAIGGSSFPGQAQVVANVPLGLPGN
ITFVPINSVDLDSLGLGSGSQTMTAGINADGHLINTGQAMDSSDNSERTGEQVSPEITET
ATDNDLFVPTSSSSQLPVTIDSSSILEQNANNLTTTSGQVHSSDLQGNYIQTSVSDDTQA
QNIQVSTAQPIVQHIQLQESQQPTSQAQIVQGIAQQTIHGVQASQSISPQALQNLQLQLN
PGTFLIQAQTVTPSGQITWQTFQVQGVQNLQNLQIQNAPGQQITLTPVQTLTLGQVAAGG
ALTSTPVSLSTAQLPNLQTVTVNSIDSAGIQLHQGENAGSPAGCTTLIQQHQTEHWEEVK
PEKRIVAKVTDALSGASVDMFNNINTNDLTHLRVQVVDEEGDQPHQEGKRLRRVACTCPN
CKEGGGSRGSNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMFCGKRFT
RSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKGIHSSSTVLASVEATS
DDTLITAGGTTLILANIQQGSVSGIGTVNTSGTSN

>Tetraodon nigroviridis Sp3
ATQLTGTDRWEVLTPTSEKDESGMIQIQSHGVFTSNGQYVLPLQNLQSQPVFVTSETDTS
SAASVPNIQYQVIPQIQTADGQLSFSTSTMEGAALAQDATGQIQILPDGSQTLGVSSAAN
ILNNNQNLISQTGNVQQIQGVSIGSSTFSNQGQVVTNVPVGLPGNITFVPINSVDLDSLG
LSGAQTIATGVTADGQLIMAGQPVDGSQNLAKTENHLPQTLPGNDSSANPELYVPTSSSQ
SQLHIPASEAALLTQDASLSSEATARSNSSSGLQEGFVQENQEPNVQASSAQPIIQLQQV
PIQTANGQVVPSVSPGGQGLQNVQLINPGTFIIQAQTVTPSGQIQWQTFQVQGVQNLQNL
QLPTSPPQQITLAPVQALSLGSAPVSISTGQIPNLQTVTVNSVAPNEGEAEGLGDIQIKE
EPDSGDWQLSTDSTLNTSDLSHLRGRLVDEDDQIGQEGKRLRRVACTCPNCKESGGRGSS
TGKKKQHICHIAGCGKVYGKTSHLRAHLRWHSGERPFVCSWMLCGKRFTRSDELQRHRRT
HTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKG

>Takifugu rubripes Sp3
STQLTGTDRWEVLTPTSEKDESGMIQIQSQGIFTSNGQYVLPLQNLQSQSVFVTSGTDTS
SATSVPNIQYQVIPQIQTADGQLSFSTSNMEGAGLAQDATGQIHILPDGSQTLNVSSAAN
ILNNQNLISQTGNVQQIQGVSIGSSTFNNQGQVVTNVPVGLPGNITFVPINSVDLDSLGL
SGAQTIATGVTADGQLIMANQPVDGSQNLVKTDNHLSQTLPVNANANREIYVPTSSSQSQ
LHIPVSESALLTQDTSLSSVTTAQTNSSSGLQDGFIQENQDQNIQVSSAQPIIQLQQVPI
QTTNGQVIQSVTPGGQGLQNVQLINPGTFIIQAQTVTPSGQIQWQTFQVQGVQNLQNLQL
PTTPHQQITLAPVQTLSLGSTPVSIGTGQIPNLQTVTVNSVALNEGEADTLGDIQIKEEP
DWQLSTDSTLNTSDLSHLRGRLVDEDDQIGQEGKRLRRVACTCPNCKESGGRGSSTGKKK
QHICHIAGCGKVYGKTSHLRAHLRWHSGERPFVCSWMLCGKRFTRSDELQRHRRTHTGEK
KFVCPECSKRFMRSDHLAKHIKTHQNKKGMNSGGSVVASMESTGSSDSIIATAGGTTLIL
TNIQQGSSNAQDILANAEIPLQLVTTVAASEVME

>Homo sapiens SP8
APGLLGEEPRLGSTPLAMLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSAS
CNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSS
SAAAAAAAAAAAASSSPFANDYSDGSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFK
PSHPGLGAAGEVGSAGASSWWDVGAGWIDVQNPNSAAALPGSLHPAAGGLQTSLHSPLGG
YNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGGSMLSAG
PSAPLGGSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKT
SHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDH
LSKHVKTHSGGGGGGGSAGSGSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE

>Mus musculus Sp8
MLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSGSCNVVGSSLSSFGVSGAS
RNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSP
FANDYSVFQAPGVSGGSGGGGGGGGGGSGAHSQDSSHQPVFISKVHTSVDGLQGIYPRVG
MAHPYESWFKPSHPGLGAAADVGSAGASSWWDVGAGWIDVQNPNGAAALPGSLHPAAGGL
QTSLHSPLGGYNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLA
GAGSSMLSAGPAAQLGGSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHI
PGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPV
CNKRFMRSDHLSKHVKTHSGGGGSAGSGGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPG
HRNGLE

> Rattus norvegicus Sp8
MATSLLGEEPRLGSTPLAMLAATCNKIGSPSPSPSSLSDSSSSFSKGFHPWKRSSSSSSG
SCNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTS
SSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSGAHSQDSSHQPVFI
SKVHTSVDGLQGIYPRVGMAHPYESWFKPSHPGLGAAADVGSAGASSWWDVGAGWIDVQN
PNGAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFRGSPRSSARRYSGRATCDC
PNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCG
KRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSGGGGSAGSGGGKKGS
DTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE

>Xenopus tropicalis Sp8
MLAATCNKIGSPSPSPSSLSDSSASFGKGFHPWKRSSSTSSSCTLASGSLSGFSVGGSSR
GGNGSSSAAAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSGVSGGGGGGGGSSGSV
SAASPFANEYSVFPVSGGSQEAAAAAAAAAAAAAAAASHHQPVFLSKVHASVDGLQSIYP
RVGMAHPYESWFKPSHPGEVSAAAAGGASSWWEVGAGWIDVQSPGAGAALHPGALQGSLH
SPLGGYGTDYSAAGLGHFSAGGGGGAGSGGGAAGAGNGGGGGPGSHLLSSGGQHIMDGFK
PVIGPGSYPDPSSSPLSAGSMLAPTGPLGGSPRSSARRYSGRATCDCPNCQEAERLGPAG
ASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHL
RTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSAGGAGGGAGSTGPGSGSKKGSDTDSEHS
PSTSPPCHSPDLLHPPDRNGLE

>Tetraodon nigroviridis SP8
EEPRLGSTPLALLAAACSRIGDPSPSCSPALSEPGLVKGFHPWKGGSGGTSNPGPFGVSS
ANCRNNGSGLTNTSSAFSVTTVNSFVGNNYSMYQTSLSSDNIISDSAHTQRSAFLTKFPP
AVEDIAGIYPRVPGHQSWFKPVGEAGSGTSSWWDIGTSWVDAPSPAGLPASLGVCNAEYS
SAFSPGAPQHLLPATQHLFDGFRQPVLAPYADPSAMGAPAAAAAATNPVSLPASSRSSSR
RYSGRATCDCPNCREAESPGQGGASPRRRGLHSCHIPGCGKVYGKTSHLKAHLRWHTGER
PFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFECAVCQKRFMRSDHLSKHVRTHSADGSE
DSGEAGARGGSDTDHSPPGSPAAPPAAPERLPTTGRQN

>Takifugu rubripes SP8
EEPRLGSTPLAMLAATCSRIGDPGPSCSPALSDGAPGLVKGFHPWKGGLGGSSNLGAFGV
PPGNCRNNGTGLANTNSAFSVTTVNSLMGNNYSMYQTSVSPDNIIPDSAHSQRSAFLKKF
PPSVEDLTGIYPRVHGHQSWFKPMGDTGNGTSAWWDIGTSWMDAQSPTGIPASFGACNTE
YSSPFSPSTSQHLLPAAQHLFDGFRPSVPAPYADTTKIGAPVVATNPVPLPASSRSSSRR
YSGRATCDCPNCQEAESLGPGGASPQRRGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERP
FVCNWLFCGKRFTRSDELQRHLRTHTGEKRFECAICQKRFMRSDHLSKHIRTHTADGSED
SGETGHGKGSSDTDTSLSGSPASQSA

>Homo sapiens Sp2
MAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKL
VPIKPAPLPLSPGKNSFGILSSKGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSN
ANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPIKPAPIQKS
STTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKA
RKKSLPASQPPVAVAEQVETVLIETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPK
AEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTPSGEVQTVL
VQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAA
QLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQME
QALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKTSLLRAHVR
LHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRSDHLTKHYKTH
LVTKNL

>Mus musculus Sp2
EAAEAREEDVVMSDPQMSMAATAAVSPSDYLQPAAATTQAKQPSPLALLAATCSKIGPPA
VEAAVTPPAPPQPTPRKLVPIKPAPLPLSPCKNSFSILSSKGNILQIQGSQLSTSYPGGQ
FVFAIQNPTLINKGSRSNASIQYQVPQIQGNSSQTIQVQPSLTNQIQVIPGTNQAITTPS
TSGHKPVPIKPAPVQKSSTTTTPVQSGANVVKLTGGGSNMTLTLPLNNLVNTSDIGGPAQ
LLTESPPTPLSKTNKKARKKSLPVSQPSVAVAEQVETVLIETTADNIIQAGNNLLIVQSP
GGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTEPT
PTQVYIRTPSGEVQTVLVQDSPPATAATTSTVTCNSPALRAPHLSGTSKKHSAAILRKER
PLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGN
NLTISGLSPTQIQLQMEQALAGEAQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIP
DCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQC
QKRFMRSDHLTKHYKTHLGTKGL


>Rattus norvegicus Sp2
EAAEAREEDVVMSDSQMSMAATAAVSPSDYLQPAAAATQAIQPSPLALLAATCSKIGPPA
VEAAVTPPAPPQPTPRKLVPIKPAPLPLSPCKNSFSILSSKGNILQIQGSQLSASYPGGQ
FVFAIQNPTLINKGSRSNASIQYQVPQIQGNSSQTIQVQPNLTNQIQIIPGTNQAIITPS
TSGHKPVPIKPAPVQKSNTTTTPVQSGANVVKLTGGGGNMTLTLPLNNLVNTSDIGAPAQ
LLTESPPTPLSKTNKKARKKSLPVSQPSVAVAEQVETVLIETTAENIIQAGNNLLIVQSP
GGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQTTEPT
PTQVYIRTPSGEVQTVLVQDSPPATAATTSTVSCSSPALRAPHLSGSSKKHSAAILRKER
PLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGVPVTITNTGGQQQLTVQNVSGN
NLTISGLSPTQIQLQMEQALAGEAQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIP
DCGKTFRKTSLLRAHVRLHTGERPFVCNWFFCGKRFTRSDELQRHARTHTGDKRFECAQC
QKRFMRSDHLTKHYKTHLGTKGL

>Gallus gallus Sp2
SALTADLTPVFLLPPCRLSDSMAATAAVSPSEYLQPAASTAQDSQPSPLALLAATCSKIG
PPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLGSGKNSFGILSSKGNLFQIQGSQVGTSYP
GGQLVFAIQNPTVISKGTRSSANIQYQAVPQIQAAGGQTIQVQPNLTNQIQIIPGTNQAI
LTPSSSSHKPVPIKPAPAQKSGASPVQGSSNVVKLTGGSNVTLTLPMNNLVNTTESSTQA
QVIAESPSKPGKKTRKKAMSPSQPSTVAVAEQVETVLIETTAENIIQAGNNLLIVQSPGS
GQPAVVQQVQVVQPKQESQVVQIPQQALRVVQAASATLPTVPQKSSQNIQIQTTESTPTQ
VYFKTPSGELQTVLLQEAPAVTVAPSSTSCSSPVSRNSGTVTSSKKPTARKERPLPKIAP
AGGVISLSAAQLAAAAQAMQTININGVQVQGVPVTITNAGGQQQLTVQNVSGNNLTISGL
SPTQIQLQMEQALSGEMQPGEKRRRMACTCPNCKDGEKRPGDQGKKKHICHIPECGRTFR
KTSLLRAHVRLHTGERPFVCNWVFCGKRFTRSDELQRHARTHTGDKRFECAQCQKRFMRS
DHLTKHYKTHLITKNL

>Tetraodon nigroviridis Sp2
EQQDSMAATAAVSPSEYLQPSTASSQDAQPSPFGLLAATCSKIGPPAAQAPVTSAPEQPQ
PRRLLPIKPAPIAPAPPKNLGFLSAKGNVIQLPAGLTPTTPGSPIVLTIQQSPARANNPT
PTNIQYQVVPQIQGAQTIQVMPQAGQIQLIPGTNHAIITTPMTIPAPTAATTSVTPQKTV
AIKPSPKPRKADTAAAGNVVQLPGGLTLPLNVATGEVGGAQVVTETASAPPIPVKGRRGR
KKKVAVAAQPPPPTPPPPPPPPPPPQPASPSSGPMETIVIEAGDNIIQAGNNLLIVQSPG
QPAVVQQVQVVQPKPDSQVVQIPQQALKVVQAASATLPPVPQKQALPQSLQVAQTEPSPT
QVSLSLSFSLSLFLFTPPHRVSSRVPNVPLIFISLRLFSKQHRGSGRRFSSRTPSPRRCL
LAAQAVQTISINGVHVVGLPVTITNTGRNPTWCLTGQQHLTVQTMQGGGLQLAATAGQPT
LQVDQTLTLELPSQPGEKKRRMACTCPNCKDADKRPGEVGKRKHICHVPGCEKTFRKTSL
LRAHVRLHTGERPFVCSWVFCGKRFTRSDELQRHARTHTGDKRFECSQCQKRFMRSDHLT
KHYKTHINTKNL

>Danio rerio Sp2
MDCFAEFLCVDIGWNSAWTLPGAQLPASLPADANEHQPTGISSLTNIGQREIRGVLEYCL
YQKDSMATTVAVSPSEYLQPSTTTSQDSQPSPLALLAATCSKIGPPAAQAPVSTPPSQPT
TRRLHPIKPAPIAPAPPKNLGFLSAKGNIIQLPAGLGSSGASPIVFTFQSPSRPAGTSTA
NFQYQVIPQFQGSQTIQMMPQGGQIQIIPGTNQAIITSPVTVQAATPTAPPLAPAPVPQH
KTVAIKPSTQKRRQNNASVNANIVRLPSGLTLPLNVTTGDVGGAQVLTETAAAPVKPKRG
RKRQVAIAAPAPAPQPASPPPVAEQVEALLIETTADNIIQAGNNLLIVQNPGGSQPAVVQ
QVQLLQQKSDQQVVQIPPQALKVVQAASATLPPVPQRQTVTPSVQVSPPEPTQVLIKTAS
GEWQAVQIQETTVTTPTTPTSTPTPAVVTKKVQTGTRKERTLPKIAPAGGGLITLNAAQL
ASAAQAVQTININGVQVQGVPVTITNAGGQQHLTVQTVPSAGLQLGSVQTQTQTMQIEQT
QTLALELQTQPGEKKRRMACTCPNCKDAEKKPGEVGKRKHICHIAGCEKTFRKTSLLRAH
VRLHTGERPFVCNWVFCGKRFTRSDELQRHARTHTGDKRFECNKCQKRFMRSDHLTKHYK
THINTKSL

>Strongylocentrotus(XP_793203)
MGTPETNVIRSVLMWCPDRAIDLEPSRKGRPPLAMLAATCDRVAEGSPESFPDPPKAKGF
HPFKRTTPTMSGLTAEHAASRFAHMAAPGSMLGASLPYPLAPSSSLTSPFSGELFFSRKT
EPRIPIATETAKSNTSPYGHKTGFSSETEHLAGILPPHLCGHSAYESWLKAATSASMLSR
ENGVHGFSPAFWSLPGAQASLLDLHSSAGTLPSHFGKMPTCSSASDCSALALSHSVLPYP
PLTTTNPHLFSPSQLFPPSSYNSFLPPGYDIMSLTEMRSSFFGPAGLGLSLSRAGRRYSG
RATCDCPNCQENERLAAAGQPLRKKNVHSCHIPGCGKIYGKTSHLKAHLRWHTGERPFVC
NWLFCGKRFTRSDELQRHLRTHTGEKRFSCPTCNKRFMRSDHLSKHVKTHQNNNNNSGND
NGGNADSKAAGETGKMSPIKKLASVGSSEAESSPSGTEGSPSPVSTGPGPISMSVPQSAA
LKVASP

>Strongylocentrotus(XP_784359)
MAKKSTKKGQSNYIQPSSMSQETQPSPLALLAATCSKIGTPAEGQAGAVNQGQTVTVLGQ
NQGQAVQIPGGFINAANAQQIQQALGLPPGFPLQFTTASTGVAGQQGTAAGGPMYIEVGP
GGNIPSSSVGGATPTKSINAANILSLNQQSATGGQQIVTNGNVQYNITPQYQIDSEGNLI
TTHVATPVSVSQAQAQTTQTVVRQAPTTTSQATNVAGSNVAQIALPGAGVQYIQNGQIIQ
AVAPQPAPTQQRIMLGSQTITLQLAPNAVMSNANSHDQPVVTPVYNIISSTPPQGNQDNS
AQTQQLQIQDQLQNAQIISNSGQIQAGNAANSNQATFVQVAGKPGQIILQQPQQAGQVQQ
IQVSGLQTSNTNVQTTQIRQQSGKVVASVIPQQTVQQQPQAQVIQIHQPIQGQAGTQISL
QQQPGTGYYTIQQPTPQPQQQAQTITLPVNVAGSQGSVQTITLPIQGNQLQGGSITIPQS
VLQSIQQINGGQFMQNPIVLKAPQTQVQTVHLQHGGTPVATPQSSSSQVQQQVITTDVSP
AISTANNSTIAGLPNYNVHLAPLSPGPGPAGNTSAVNINTSTAATQQQITQQQQQQISQA
LVGMKAEKQQQASWQGVIQTEATGGAQGGTVTTISTNGTNYPPTMASYELQIDQSQIPKQ
EPPKKVRRLACTCPNCKDGDGRNSEKGKKQHICHIADCGKIYGKTSHLRAHLRWHTGERP
FVCDWLFCGKRFTRSDELQRHRRTHTGEKKFVCKSCGKKFMRSDHLAKHQRTHIRKPGTV
SMKGQSGGGDAPLQVDLSQGVDEFDEEMEKVMRDPQHEAMVQDAVQEAVY