>Homo sapiens_RAPGEF4(ENSP_380271) MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Gorilla gorilla_RAPGEF4(ENSGGOP_8927) MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFSTGDERAQK RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVATFELMSSKDLAYQM TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Mus musculus_RAPGEF4(ENSMUSP_88336) MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Rattus norvegicus_RAPGEF4(ENSRNOP_10630) PNKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQ CCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEH EDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTADDLEIIYDELLHI KALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCT LHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDV LVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFV MMHCVFMPNTQLCPALVAQYPFPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQED DVAMAFLEEFYVSVSDDARMMVAFKEQLAELEKTVKQISEDAKAPQKKHKVLLQQFNTGD ERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMN SGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKD LAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCS QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAE FESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIA NTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Bos taurus_RAPGEF4(ENSBTAP_53320) MVAAHAAHSSSSAEWIACLDKKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCG YYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILD NTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDTFPSKEQ TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT ELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPL PTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSH LSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGD DFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEK VPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCV FMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAM AFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQ KRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGE KVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQ MTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSK RVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESL MDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTAR TVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Loxodonta Africana_RAPGEF4(ENSLAFP_8236) MVAAHAAHSSSSTEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPANTITKVPSEKILRAGKILRNVILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMMQQTQCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRASNQGNSQSQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVF MPNTQLCPALVAHYHAQPSQGTEQEKMDYTLNNKKRVIRLVLQWAATYGDLLQEDDVAMA FLEEFYVSVSDDARMIAALKEQLPDLEKIVKQILEEAKAPQKKHKVLLQQFNTGDERAQK RQPIRGSDEVLFKVYCMDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMSSGGEK VLLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFTDNLVNFEKMRMIANTART VRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Monodelphis domestica_RAPGEF4(ENSMODP_11330) MVAGHAAHFSSSAEGIPCRDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETSANNDRHFIFQTP LIEPHVPLRPAKTITQVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTEL VDWMIQQTPCVHSRAQAVGMWQVLLEEGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPT EEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELIHIKALSHLS TTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDF GKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVP AGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETVRLEQPLNEVTDSVLNDFIMMHCVFM PNSQLCPALVAQYPFIPSQGTEQDKMDYALNNKRRVIRLVLQWAALYGDLLQEDEVAMAF LEEFYVSVSDDSRMIAALKDQLPELEKMVKQISEDAKAPQKKHKVLLQQFNPVEDRAQKR QPVRGSDEILFKVYCLDHTYTTIRVPVSASVKEVISAIADKLGSGEGMIIVKMSSGGEKV VLKPNDVSVFTTLTVNGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMT IYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCAQLSKRV QLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKIYAEFESLMD PSRNHRAYRLTVTKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTVRTV RYCRSQTFNPDAALANKNHQDVRGYVRQLNVIDNQRTLSQMSHRLEPRR >Gallus gallus_RAPGEF4(ENSGALP_10246) GRGEPPPPPAGCAATSSLSNMVAAHTSHSASSGEWIACLDKRPLERSSEDVDIIFTRLKE VKAFEKFHPNLLQQICLCGYYENLEKGITLFRQGDIGSNWYAVLTGSLDVKVSDTSNHQD AVTICTLGIGTAFGESILDNTPRHATIVTREYSELLRIEQKDFKALWEKYRQYMSGLLTP PYGVMETGSNNDRMPDKKNTPLIDSHIPHRPSKTITQVPSEKILRAGKILRNTILSRAPH MIRDRKYHLKTYRQCCVGTELVDWMMQQSTCVHSRSQAVGMWQVLLEEGVLNHVDQEHHF QDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQIGPDAHMRMILRKPPGQRS IDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHPKAGTVLFNQGEEGTSWYIILKG SVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDV EANTVRLKEHDQDVLVLEKIPAGNRVSNQGSSQPQHKYIVMSGTPEKILEHFLETMRLEA TLNEATDSVLNDFIMMHCVFMPNSQLCPALMAHHGTYHAQPSQGTEQEKMDYALNNKRRV IRLVLQWAALYGDLLQEDEAAMAFLEEFYVSVSDDTRMIAALKEQLPELEKIVKQVAEEP KAPQKKHKVLLQLFNTSDDRAQKRQPIRGSDEVLFKVYCIDQTYTTIRVPVSSSVKEVIS AVADKLGSGEGLIIVKMSSGGEKVVLKPHDVSVFTTLSVNGRLFACPRDQFDSLAPLPEQ EGPSAGTVGTFELMSSKDLAHQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFL RRFNEIQFWVVTEICLCSQLSKRVQLLKKYIKIAAHCKEYKNLNSFFAIIMGLSNVAVSR LSLTWEKLPSKFKKIYAEFESLMDPSRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTHEG NKTLTDNLVNFEKMRMIANTVRTVKFCRSQSFNPDAALANKNHQDVRSYVRQLNVIDNQR TLSQMSHRLEPRRA >Xenopus tropicalis_RAPGEF4(ENSXETP_16383) PIMVAAHTAHSTSSAEWIACLDKRPLERSGEDVDIIFARLKEVKAFERFHPNLLQQICFC GYYENLEKGITLYRQGDIGTSWYAVLTGSLDVKVSETNNHQDAVVICTLGVGTAFGESIL DNTPRHATIVTRENSELLRIEQKDFKTLWEKYRQYMAGFLAPPYGVLETGSNDSKLSDKE NTPLIENQIPIRPAKTITEVPSERILRAGKTLRNAILTRAPHMIRDRKYHLKTYRQCCVG TELVDWLMQQSSCVHSRTQAVGMWQVLLEDGVLNHVDQEYYFQDKYLFYRFLDDEHEDAP MPTEEEKKESDEELQDTLLLLSQIGPDAHMRMILRKPPGQRSADDLEIIFEELIHIKALS HLSTTVSPFLELHCILKKKVFQSRRSTKIIIFNQGEEGTSWYIILKGSVNVVIYGKGVVC TLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQD VLVLEKILAGSQGSAQGNTQSPYKYTVMSGNPEKLLEHFLETMRLDPSLNDATADTALDD FILMHCVFMPNSQLCPALMSQYHAQPSQGTEQEKLDYTLNNKRRVIRLVQQWATLYGDLL REDEVSMAFLEHFHKGTNAKIESKKLVAALSRDLQKIKRLIMNISEDAKGQQKKHKVLLR QFSTGDERLQKRQAIRSSDELLFKVYCIDHTYTTIRVAVAASVKEVLSAVADKLGSGDSL ILVKISSAGEKVVLKPNEISVFTTLSVNGRLFACPRDQFDSLTPLPEQEGPSAGTMSTFE LMSSKDLAYQMTIHDWDLFSCVHELELIYHTFGRQNFKKTTANLDLFLRRFNEIQFWVVT EICLCPQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLSLTWEKLPSKF KKIYAEFENLMDPSRNHRAYRLTVAKLDPPIIPFTPLLIKDMTFTHEGNKTFIDNLVNFE KMRMIANTLRTIRYCRSVPFNPDASLAGKNHQDVRNYVRQFNVIDNQRTLSQMSHRLEPR RA >Danio rerio_RAPGEF4(ENSDARP_114027) MISPKMVAAHTSSHPSASADWIVCLDKRPEERSGEDVDIIMVRLKSVKAFEKFHPPLLQQ ICLCGFYECLEKGITLYRQGDIGTNWYTVLSGSLDVKVSETANHQDAVTICTLGIGTAFG ESILDNTPRHATIVTREFSELLRIEQKDFRNLWENYRQCMAGLLVPPYGVMDSGPNADRM PDKENLSNSSPGLSPKHLNKVPSEKILRAGKVLRNIILSRAPHMIRDRKYHLKTYRRSCI GTELVDWLLQHTSCVHSRVQAVGMWQVLLEEGVLNHVDQEPTFQDKYLFYRFLDDESEDS GMPSEEDKKESDEELQDTLLLLSQIGPDAHLRMILRKQPGQRTVDDLEIIYEELLHIKAL SHLSTTVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE GDDFGKLALVNDAPRAASIVLREDFCHFLRVDKEDFNRILRDVEANTVRLKEHEEDVLVL EKANNRSSSSSPLKYTVMSGTPEKILEHLLETMKLDCQFSESDPALDDFLLMHCVFVPNS QLCPLLMTQYPSLIKPYCFSTKTPHQASQGSEQERMDYTLNNKRRVVRLVLQWASINTDH LQEEDSSFSFIQEFYEMVCEDSRLTPALKDHLPELEKIIKQNSDDGRPSQKKHKVLLRQF STGNDRLQKRQPIKSTDENKELLKPSDVSIFSSLSINGRLFVCPRDQIDSLTPLPEQEGP SAGSMSTFELMSSKDLAHQMTLYDWELFHCVHEHELIYHTFGRHHFKKTTANLDLFLRRF NEVQLWVVTEVCLCPALSKRVQLLKKFIKIAAHCKEFKNLNSFFAIIMGLGNPAVCRLSQ TWEKLPSKFKKFYGEFENLMDPSRNHRAYRLTMAKLEPPIIPFMPLLIKDMTFTHEGNKT FTDRLVNFEKMRMIANTVRIIRYCRSQPFDQEAPQATGKSHQDVRTYVRHISVIDNQRSL SQLSHRLEPRRT >Takifugu rubripes_RAPGEF4(ENSTRUP_45217) MVAAHPSSHSSESAQWIICLDKRPAERSGEDVDIILARLKKAKAFEHFHPSLLHQICLCG FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSYHQDAVVICTLGTGTAFGESILD NTPRRATIVTREFTELLRIEQREFRCLWERYHHCMAGLLVPSYGVMESACSADRMPNKEN VSDNPFVSIGKHQNKVPSEDILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELV DWQMQQSSCVRSRLQAVGMWQVLLEEGVLNHVDQELSFQDKYLFYRFLDDEQEDALFPSE EERRESQEELQDTLLLLSKIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST TVKRELAGVLIFESHAKAGTVLFSQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG KLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHGQDVLVLERSLG NSRSSIHGASSSQYKYTIMSGTPEKILEHLLEMMRLDSQFTESADSALDDFVLTHPVFIP NSQLCPVLMAHYHAQASQGCEQERMDYTLNNKRRVIRLVMRWAAVHGDHLLEEEDVVAFL QEFLVAVSNDAKVLPALREQLAKLEITVKHYTEDARISRKKHKVFLRQFSTGEEKLQKRQ PIKSNDEILFKVYCCDNTYTTIRAPVAASVRELISSLAEKLGSTEDLLLVSLGSAGEKVI FKPNDVSVFSTLSINGRLFVCRRDELDSLTPLPEQVEPSAGLSSNFELMSSKDVACHMTS YDWELFNCVHELELIYHTFGRQNIQKTTVNLDLFLRRFNEIQFWVITEMCLCSQLSKRVQ LLKKFIKIAAHCKEYKNLNGFFAITMGLSNPAVCRLNMTWEKLPSKFRKFYREFENLMDP SRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTQEGNKTFIDTLVNFEKMRMIANTVKILR YCRSQPFSPDSPQAGKSHSDVRAYVRQFNVIDNQRTLSQLSHSLEPPRS >Tetraodon nigroviridis_RAPGEF4(ENSTNIP_20064) MVVAHASSHPSESAEWIICLDKRPAERSGEDVDIILARLRRVKALERFHPSVLQQICRCG FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSYHQDAVVICTLGTGTAFGESILD NTPRHATIVTRECTELLRIEQRAFRSLWERYHHCMAGLLVPPYGVMESACSADRMPNTEN ISDDAFVSADKHQNKVPSENVLRAGKILRNAILSGAPHMIRDRKYHLKTYRRCCVGTELV DWQMQQSSCVRSRVQAVGMWQVLLEEGVLSQVDQELSFQDKYLFYRFLDDEQEDAPFPSE EEERESQEELQDALLLLSQIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST TVKRQLAGVLIFESHTKAGTVLFSQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG KLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHGQDVLVLERSLG NSRTSVHGASSSQYKYTIMSGTPEKILEHLLEMMRLDSQFTESADSALDDFLLTHPVFIP NSQLCPVLMAHYHAQASQGCEQERMDYTLNNKRRVIRLVMQWAALHGDHLQDEEDSVVFL QEFLVAVSNDAKVLPALRDQLAKLETTVKHYAEDARVSQKKHKVFLRQFSTGEEKLQKRQ PIRSNDEILFKVYCCDNTYTTIRASVAASVRELMGALAEKLGSAEDLLLVSLGSAGEKVI FKPNDVSVFSTLGINGRLFVCRRDELDSLSPLPEQVEPSAGLSSNFELMSSKDVACHMTS YDWELFSCVHEFELIYHTFGRQNFRKTTVNLDLFLRRFNEIQFWVITEMCLCSPLSKRVQ LLKKFIKIAAHCKDYRNLNGFFAVTMGLSNPAVGRLSLTWEKLPSKFRKFYREFENLMDP SRNHRAYRLTAAKLDPPIIPFMPLLIKDMTFAHEGNKTFVDNLVNFEKMRMIANTVKILR HCRSQAFSPDSPPAGKNHSDVRAYVRQFNVIDNQRTLTQLSHGLEPPRP >Gasterosteus aculeatus_RAPGEF4(ENSGACP_6371) MVAARTSSHSSESVEWIICLDKRPAERSGEDVDIILARLKNVKAFERFPPILLQQICLCG FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSSYQDAVTICTLGAGTAFGESILD NTPRHATIVTREFSELLRIEQREFRSLWEKYHQCMAGLLAPPYGVMESGCSGDTMPDKEN ISNNSFVSVSKHQNKVPSEKILRAGRILRNAILSGAPHMIRDRKYHLKTYRRCCVGTELV DWQIQQSSCIHSRVQAVGLWQVLLEEGVLNHVDQELSFQDKYLFYRFLDDEQEDAPLPGE AEGKESQEELQDTLLLLSQIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST TVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG KLALVNDAPRAASIVLREDNCHFLTVDKEDFNRILRDVEANTVRLKEHGQDVLVLEKSLG SSRASTHGASSSHYKYKVISGTPEKILEHLLEMMRLDSQFTESADSALDDFVLTHCVFIP NGQLCPVLMAHYHAEALQGSEQEKRDYTLNNKRRVIRLVMQWAAVHRDHLQEEDTSVAFL EEFVTAVSNDVKALPALGDQLTELERSLKRNTDDARVSKKKHKVLLRQFSMGDEKLQKRQ PIKSNDEILLKVYCCDHTYTTIRVPVGASVREVVGAVADKLGSAEDLLLVGLSSAGEKVI FKPNDVSVFSTLSINARLFACRRDQLDSLTPLPEQEGSSTGPLASFELMSSKDVAYHMTS YDWELFHCVHELELLYHTFGRQNLKKTTVNLDLFLRRFNEIQFWVITEMCLCSQLSKRVQ LLKKFIKIAAQSCKEYRNLNAFFAVIMGLSNPAVCRLSQTWEKLPSKFKRFYGEFENLMD PSRNHRAYRLTVAKLEPPIIPFMPLLIKADMTFTHEGNRTFIDYLVNFEKMRMIANTLKI VRYCRSQAFSPDSTQASKNQAEVRTYVRQFKVIDNQRTLSQLSHRLEPRRS >Oryzias latipes_RAPGEF4(ENSORLP_21824) MVAARTSAHSSQTADWINSLDKRPEERSSEDVDIILARLKKVKAFKGFNPSLLQQICLCG FYEGLEKGIMLYRQGDIGTSWYTVLSGSLDVKVSETSSYQDGVTICTLGTGTAFGESILD NTPRHATIVTREFSELLRIEQKEFRSLWEKFYYCMAGLLVPPYGVMESTCGSDRIPDKEN IPFVPLSKHPNKVGNSIFPTLSEKILHAGKILRNAILSKAPHMIRDRKFHLKTYRQCCVG TELVDWLMQQSSCVHSRPQAVGMWQVLLEEGVLNHVEQEMNFQDKYLFYRFLEDEREDAP LPSEEEKGESQEELQEALLFLSQTGPDAHLRMILRKPSSDRAADDLEIIYEELLNIKALS HLSTTVKRELAGVLIFESHAKAGTVLFNQGDEGTSWYIILKGSVDVVIYGKGVVCTLHEG DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLEEHGQDVLVLE KTLGSARNSADGSSAVHYKYRVMSGTPEKILEHLLKMMRLDLQFTESVTDSALDDFVLMH CVFVPNSQLCPLLRAHYHAQASQGSEQEKLDYALNNKRRVICMIMKWATVHDDQLQQEDV AFLQESLISASNDATWLPALGDQLTELERVVKRCAEAAMASQKKHKVFLRQFSLGEEKPQ KRQPIRGSDEILFKVYCCDHTYTTIRVPVAASVQEVISAVADKLGSVEELNLVHLSSAGE KTIFKPNDVSVFSTLSVNGRLFACRRDQLDSLTPLSEQGGPSSGSLSSFELMSSKDVAYH LTSYDWELFHCVHELELIYHTFGRQHINKTSVNLDLFLRRFNEIQFWVITEICLCSQISK RVQLLKKFIKIAAHCKDYKNLNAFFAIIMGLSNPAVSRLSQTWEKLPSKFKKFYGEFENL MDPSRNHRSYRLIFSKLEPPVIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIAKTVK IVRYCRSQTFSEDAPLPSKHHPDVWTYVRQFNVIDNQRILTQLSHGLEPRRS>Homo sapiens_RAPGEF2(ENSP_264431) MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV >Pan troglodytes_RAPGEF2(ENSPTRP_28421) MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV >Gorilla gorilla_RAPGEF2(ENSGGOP_24246) MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV >Macaca mulatta_RAPGEF2(ENSMMUP_13870) MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS TTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE TSPVAPRAGSQQKAQSLLQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGVGRMERRTMMEPDQY SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSITSVTTEETKSVPMPAHIAV ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV >Mus musculus_RAPGEF2(ENSMUSP_114119) MKPLAAPANHGVLGQQEKQSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSCS KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFS TTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPE GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE VATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKKFEEVINQETFWVASEILRETN QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL QDLFDPSRNMAKYRNVLSGQNLQPPVIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSANATVLDVAQTGGHKKRVRRSS FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATSTLPKNPGDKKPVKSE TSPVAPRAGPQQKVQPQQPLAQPQPPHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSP QALKKILSLSEEGSLERHRKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFS DSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYS LGSYAPVSESRGLYAAATVISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQ TIQHQRSWETLPFGHTHFDYSGDAASIWASGGHMDQMMFSDHSTKYNRQNQSRESLEQAQ SRASWASSTGYWGEDSEGDTGTIKRRGGKDVSAEAESSSMVPVTTEEAKPVPMPAHIAVT PSTTKGLIARKEGRYREPPPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARP TEAPAPGQTPPAAAASRPGSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV >Rattus norvegicu_RAPGEF2(ENSRNOP_37119) SQLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGL PETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFAN MTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNS FGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHR ELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLE WFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACA AKAKRRSMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSSSKATEAGLKRGDQILEVNG QNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKAS RYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQS QDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTPDLPDQVLRVFKADQQ SRYIMISKDTTAKEVVIQAIREFAVTATPEQYSLCEVSVTPEGVIKQRRLPDQLSKLADR IQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEP TEYIDDLFKLKSKTSCANLKKFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHC RECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLS GQNLQPPVIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPA LMFRTRKKKWRSLGSLSQGSANATVLDVAQTGGHKKRVRRSSFLNAKKLYEDAQMARKVK QYLSNLELEMDEESLQTLSLQCEPATSTLPKNPADRKPVKSETSPVAPRAGPQQKAQPQQ PLAPPQPSHKVSQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERH RKQAEDTISNASSQLSSPPTSPQSSPRKGYALALSGTVDNFSDSGHSEISSRSSIVSNSS FDSVPVSLHDERRQRHSVSIVESNLGVGRMERRTLMEPDQYSLGSYAPVSESRGLYAAAT VISSPSTEELSHDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHF DYSGDATGIWASGGHMDQIMFSDHSTKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEG DTGTIKRRGGKDVSTEAESSSMVPVTTEEAKPVPMPAHIAVTPSTTKGLIARKEGRYREP PPTPPGYVGIPIADFPEGPCHPARKPPDYNVALQRSRMVARPTEAPAPGQTPPAATASRP GSKPQWHKPSDADPRLAPFQPQGFAGAEEDEDEQVSAV >Bos taurus_RAPGEF2(ENSBTAP_29739) MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL TYRTFLCSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN LEREKMGGHLRLLNIACAAKAKRRLMTLTKPAREAPLPFILLGGSEKGFGIFVDSVDSAS KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTATPDQYSLCEVSVTPE GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE VATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKTFEEVINQETFWVASEILRETN QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPTDKKPVKSE TSPVAPRAGLQPKAQPQPQPPQPPHKLNQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQA LKKILSLSEEGSLERHRRPAEDTISNTSSQLSSPPTSPQSSPRKGYTLAPSGTVDNFSDS GHSEISSRSSIVSNSSFDSLPVSLPDERRQRPSVSIVETSLASGRLERRPAVEPDQYSLG SCAPLSESRGLYAAATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNIQTI QHQRSWETLPFGHTHFDYPGDAAGLWASSSHMDQIMFPDHSAKYSRQSQSRESLDQAQSR ASWASSTGYWGEDSEGDTGTIKRRGGKDVSLDADSSSMTAVTAEEAKPAAMAAHIAVTPS AAKGLIARKEGRYREPPPTPPGYVGIPITDFPEAHPHPARKPPDYTVALQRSRMLARPAE PPAPGSARPAPRPQWHRPGDGDPRAGPCAPPGLTAEEDEDEQVSAV >Loxodonta Africana_RAPGEF2(ENSLAFP_0251) LRGIFYLEKEAFSTQEMAFLVRCYANCLQPWSSKLPADFTKLHLADSLHPQVTHVSASHS GCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDI VRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLND GEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMKTKVDDCQFVCI AQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEE HSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEG DPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFLLLGGSE KGFGIFVDSVDSGSRATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTN LFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANT VGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSN PDLLQSHHRILDFSTTPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVVQAIREFAVTTT PDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELL RESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLKSKTSCANLKTFEEVINQ ETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTW EKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDS KVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNAAVLDV AQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNLELEMDEDSLQTLSLQCEPATNT LPKNPGDKKPVKSETSPVAPRAGSQQKAQPQPPSQQQPLPHKISQGLQVPAVSLYPSRKK VPVKDLPPFGINSPQALKKILSLSEEGSLERHKKPAEDTVSNASSQLSSPPASPQSSPRK GCTLAPSGTVDNFSDSGHSEISSRSSIVSNSSFDSVPVSLHDERHQRHSVSIVETSLGVG RLERRAVMEPDQYSLGSYAAVSESRGLYATATGISSPSTEELSQDQGDRASLDAADSGRG SWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPPGLWASSSHMDQIMFSDHSTKY NRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSVEAESSSLAPVPTE EAKPAPVPAHIAAPSSTAKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPD YTVALQRSRMVARSSEVPGPSPVQQPHGHPASSRPVNKPQWHKPNESDPRLAPYQSQGFS AEEDEDEQVSAV >Taeniopygia guttata_RAPGEF2(ENSTGUP_5920) LPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPE TAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMT MSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGRTEILCMGNSFG VSPTMEKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHREL DRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWF NDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAK AKRRLITLTKPSREAPLPFILLGGSEKGFGIFVDSVDFGSKATEAGLKRGDQILEVNGQN FENIQLTKAMEILRNNTHLSITVKTNLFVFKELLTRLSEEKRNGAPHLPKIGDIKKASRY SIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKTRISILPQKPYNDIGIGQSQD DSIVGLRQTKHIPPALPVSGTLSSSNPDLLQSHHRILDFNTTPDLPDQVLRVFKADQQSR YIMISKDTTAKEVVIQAIREFALTATPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQ LSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTE YIDDLFKLKSKTGCTNLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRE CKNFNSMFAIISGLNLAPVARLRTTWEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQ NLQPPIIPLFPVIKKDLTFLHEGNDSKVEGLVNFEKLRMIAKEIRHVGRMASVNMDPALM FRTRKKKWRSLGSLSQGSANAAVLDVAQAGGHKKRVRRSSFLNAKKLYEDAQMARKVKQY LSNLDLEMDEESLQTLSLQCEPATNTLPKNTGDKRSGKSETSPVAPRAGIQQKVQQQHKV NQALQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLDRHKKQSEDTVSSA SSQLSSPPTSPQSSPRKGYTLAPSSTVDNFSDSGHSEISSRSSIVSNSSFDSMPVPLHDE RRQRHSVSIVETNLGVGRIDRRIMIEPDQYSLGSYAPLSETRGLYAGATVLSSPSTEELS QDQGDRASLDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHAHFDSSGDGAGLWA SGGHMDQLMFPDHGTKYGRQSQGREGLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGK DVSIEADTSSITSVPAEETKPAPVPPHTAAASSSTKGLVARKEGRYREPPPTPPGYVGIP IAEFAEGGSHPARKPPDYNIALQRSRMVARTCETHGTATPQQQSHGHSTGRPVNKPQWHK PNESDPRLAHYPSQGFSTEEDDTEQITQI >Xenopus tropicalis_RAPGEF2(ENSXETP_26249) QDLEIVYSYLHGMEALSNLREHQLRLMCETVRYERHEANEVLYYPDDIGTCWYILLSGSV FIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQSRRR FRKINQKGERQTIIDTVESYPVGKPPLPRGYHTLPADFTKLHITDSLHPQVTHVSSSHSG CSITSDSGSSSLSDIYQQATESEPGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDI VRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTVVLND GEELDSWSVILNGSVEVTYPDGRTEILCMGNSFGVSPTMEKEYMKGVMRTKVDDCQFVCI AQQDYCRILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEE HSVVDPTYIEDFLLTYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEG DPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLITLTKPSREAPLPFNLLGGSD KGFGIFVDSVDPGSKAAETGLKRGDQILEVNGQNFENIQLTKALEILRNNTHLSLTVKTN LFVFKELLARMLEEKRNSAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVSKKGKANT VGGRNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGLRQTKHMPATLPVSGTLSSSN PDLLQSHHRILDFNTTPAEQPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFALTA VPDAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQDL LRESQISLLQLSTIEVATQLSMRNFELFRNIEPTEYIDDLFKLKMKTGCTNLKNFEEVIN QETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRTT WEKLPSKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGND SKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTSGKVLLSLKRSLSQGSTNATVL DVAQSGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSDLDLEMDEENLQTLSVQCEPAT NTLPKNPCEKRAGKPDTSPVAPRAAAQHKQQQQQQTKVNQALQVPAVALYPSRKKVPVKD LPPFGINSPQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQCSPRKGYTMA ASGTVDNFSDSGHSEISSRSSIVSNSSFDCVHLHDDRRQRHSLSIVETNLGVGRADRRAI IDADQCSLGSYAPVAETRGLYAGATVLSSPSMEELSQDQGDRASLDAADSGRGSWTSCSS GSHDNIQTIPHQRSWETLPFGHVHFDNTADGSGFWATGGHMDHGIFPDHSTKYGRYSQGR EPLDQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVALEAETSSITSMTPEETKPLPV PTHVAVTASSAKGLIARKEGRYREPPPTPPGYVGIPIADFADGHPPLSRKPPDYNVALQR SRMMARRSESEGSAATSPPSHNQTSGRTANKPQWHKPNEADPRLALYQAQGVTEKDDADD EQVSAV >Danio rerio_RAPGEF2(ENSDARP_4657) MASYVDNSFRQAVMVNPSDRTQQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEA NEVLYYPDDIGTCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVV DYMDENEEYFQRQASHRQSRRRFRKINQKGERQTIIDTVDPYPAGKPPVARGYHTLPADF SRLHLADGIHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEPGDMDLSGLPETAVDS EEDDDEEDIERASDPLMSRDIVRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRR ELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTHPDSRNEILCMGNSFGVSPTM EKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGT RKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDFLLTYRTFLPSPMVVGKRLLEWFHDPSL RDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFEYNLEREKMCGHLRLLNIACAAKAKLRV VTLTKPSREAPLAFTLLGGSEKGFRIFIDSVEPGSKAAEAGLKRGDQILEVNGQNFENVP LSKANEILKNNTHLSITVKTNLLVFKELLARPDQDQEQEQEEEPDRKNGAPHIPKIGDIK KASRYSIPDLAVDVEQVMDLEKASKKAKANSAGGRNKLKKIFDKTLTSILPPKPYNDVGV GQSQDDSIVGLKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFNNQPDMSDQVLRVFKA DQQSRYIMIGKDTTAKEVVAQAIREFALTAAAEAYSLCEVSVTPEGVIKQRRLPEQLSKL ADRIQLSGRYYLKSNMETETLCSDEDAQELLRESHISLLQLSTVEVATQLSMRAFELFCA IEPTEYIDDLFKLKTRLTGPPSLKLFEEAINRETFWVATEVVREANQLKRMKIVKHFIKI ALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFSDLQDLFDPSRNMAKYR NLLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMAAVN MDPALMFRTRKKKWRSLGSLSQGSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMA RKVKQYLSNLTLETNEESLQTLSMQCEPSINTLPKSSGDRKRPDTSPVVSRAATHQRQQL QKANQALQVPAVALYPSRKKVPVKDLPPFGTSSPQSLKKILSLSEEAGDRHRKQAEDSVS NNSSQLSSPPTSPHSSPKKGYGRAGDYLSDSGHSEISSRSSLVSTSSLDMGQDERRQRYG GTAGEGHGSGHRLERRATADPDQYSLGSYSSMQDCRGLYAGATVLSSPSSEELTQDQGDR VSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWEALAEGAGLWGSRGSWASACSSSSSVA CWGEDSEGDTGTIKRRGGRDVTTDPETSSITSTGSEESRQHSRRPSPITAGNTKASITRK DGRYRDPPPTPPGYTALTITDVTEGTPHSGRKPPDYTTALQRSRLVTHSLDSQQPPAAGK PDPRGREEDEAVEVEEEGECLSPKLRAQRRRGPHTAVPPRP >Takifugu rubripes_RAPGEF2(ENSTRUP_9873) SQDLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGSCWYILLSGS VFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQSRR RFRKINQKGERQTIIDTVDPYPAGKPPIARGYHTLPADFSRLHLADGLHPQVTHVSSSHS GCSITSDSGSSSLSDIYQATENEPGDMDLSGLPETAVDSEEDDDEEDIERSSDPLMSRDI VRDCLEKDPMDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLND GEELDSWSVILNGSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCI AQQDYCCILNQVEKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEE HSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVLLWVNNHFNDFEG DLAMTHFLEEFENNLEKEKMCGHLRLLNIACAAKAKPRLVTLTKSARDSPLAFSLLGGQE KGFPIFIDTVEPGSKAAEVGLKRGDQILEVNGQNFENVQLTKANEILKNNTHLSITVKTN LLVFKELLTRPEHDHDLDAEEEHDRKNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLE KASKKAKTNTVGGRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIVGMKQSKQIPQPL PVSGNLSSSNPDLLQSHHRILDFNNQPDMTDQVLRVFKADQQSRYIMIGKDTTAKEVVAQ AIREFALTAAADAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETL CSDEDAQDLLRESQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKLRSKLSSAS LKRFEEAINHETFWVATEVTREPNQLKRMKTIKHFIKIALHCRECKNFSSMFAIISGLNL APVSRLRGTWEKVPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKD LTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQ GSANAAVLDVTQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSKLSLETNEDSLQTL SLQCEPSISTLPKNASGKRPDTSPVVSRAASQQRGQLAKGNQALQVPAVALYPSRKKVPV KDLPPFGTSSPHSLKKILSLSEEGNERHRRQPEDTMSNASSQLSSPPTSPQSSPKKGYTR MGDAYSDSGHSEISSRSSLVSNSSFDMAQDERRLRHSGLGESHIGGSRLERRATTDPDQY SLGSYSSMQDCRGIYTGCPTVLSSPSSEELTQDQGDRVSLDAADSGRGSWTSCSSGSHDN IQTMQQGRSWETLAFGGGGGGLGGLPPGGPDSLLGGSAALWAAQARGSWASASSSSSSAA YWGEDSEGDTGTIKRRGGKDINADPETSSITSTGSEEAKQLGRPSPSPITAGGKGLLSRK ESRYREPPPTPPGYTALSISDLGDGHQQPPTATTSTLTHTGRRPPDYTTALQRSRMVTQS PDS >Tetraodon nigroviridis_RAPGEF2(ENSTNIP_16020) MKPLAPSDSNGVPSQQDKPPLPADFSRLHLADGLHPQVTHVSSSHSGCSITSDSGSSSLS DIYQATENEPGDMDLSGLPETAVDSEEDDDEEDIERSSDPLMSRDIVRDCLEKDPMDRTD DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS VEVTYPEGRTDILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQVEK NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTAERLTMHLVEEHSVVDPTYIEDFLL TYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTHFLEEFENN LEREKMCGHLRLLNIACAAKAKPRLVTLTKPARDSPLAFSLLGGQEKGFPIFIDAVEPGS KAAEVSLKRGDQILEVNGQNFENVQLTKANEILKNNTHLSITVKTNLLVFKELLTRPEHD HDLDAEEEHDRKNSAPHLPKIGDIKKASRYSIPDLAVDVEQVMGLEKASKKAKTNTVGGR NKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIVGMKQSKQIPQPLPVSGNLSSAGSNYS CVCDCPDMTDQVLRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAADAYSLCEVSV TPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDEDAQDLLRESQISLLHLS TVEVATPLSMRAFELFPIEPTEYIDDLFKLRSKSSSSSLKRFEEAINHETFWVATEVTRE PNQLKRMKTVKHFIKIALHCRECKNFSSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFG DLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLR MIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSANAAVLDVTQTGGHKKRVRR SSFLNAKKLYEDAQMARKVKQYLSKLSLETNEDSLQTLSLQCEPSISTLPKNAGGKRPDT SPVVSRAASQQRGQLAKGNQALQVPAVALYPSRKKVPVKDLPPFGTSSPQSLKKILSLSE EGNERHRRQPEDTMSNASSQLSSPPTSPQSSPKKGYTRMGDANSDSGHSEISSRSSLVSN SSFDMVQDERRLRHSGGSRLERRATTDPDQYSLGSYSSMQDCRGIYTGCPTVLSSPSSEE LTQDQGDRVSLDAADSGRGSWTSCSSGSHDNIQTMQQGRSWETLAFGGGGGGIGGLPPGG PDSLLGGSAALWAAQARGSWASASSSSSSAAYWGEDSEGDTGTIKRRGGKDINADPETSS ITSTGSEEAKQLGRPSPSPITAGGKGLLSRKESRYREHRPRAPGYTALSISDLGDGHQHA STVPASTATHTGRRPPDYTTALQRSRMVTQSPDS >Gasterosteus aculeatus_RAPGEF2(ENSGACP_21953) DLEIVYSYLHGMEALSNLREHQLRIMCETVRYERHEANEVLYYPDDIGSCWYILLSGSVF IKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVVRNAPRRNLGLKRGSLSGRRGFIQ LSHPCEARTAIEHEYVNVFLELPADFSRLHLADGLHPQGPHVSSSHSGCSITSDSGSSSL SDIYQATENEPGDMDLSGLPETAVDSEEDDDEEDIERASDPLMSRDIVRDCLEKDPMDRT DDDIAEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILN GSVEVTYPEGRTEILCMGNSFGVSPTMEKEYMKGVMKTKVDDCQFVCIAQQDYCCILNQV EKNMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTYIEDF LLTYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVLLWVNNHFNDFEGDSAMTRFLEEFE NNLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRDSPLAFSLLGGQEKGFRIFLDAVEP GSKAAEVGLKRGDQILEVNGQNFENVQLIKANEILKNNTHLSITVKTNLLVFKELLTRPE QDHDADGEEEHDRKNGAPHLPKIGDIKKASRYSIPDLAVDVEQVMGLEKASKKAKSNSVG GRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIVGMKQSKQIAPALPVSGNLSSSNPD LLQSHHRILDFNNQPDMSDQVLRVFKADQQSRYIMIGKDTTAKEVVAQAIREFALTAAPE AYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKSNMETETLCSDDDAQDLLRE GQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDDLFKHRSKAGSASLKRFEEAINDET FWVATEVTREPNQIKRMKTVKHFIKIALHCRECKNFNSMFAIISGLNLAPVSRLRGTWEK LPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQPPIIPLFPVIKKDLTFLHEGNDSKV DGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTRKKKWRSLGQGSANAAVLDVTQTGG HKKRVRRSSFLNAKKLYEDAQMARKVKQYLSHLSLESNEESLQTLSMQCEPSISTQEENE RHRRQPEDT >Oryzias latipes_RAPGEF2(ENSORLP_25047) ADRPADRAADRAADRGHPVRTTKDLEIVYSYLHGMEALSNLREHQLRMMCETVRYERHEA NEVLYCPEDIGSCWYILLSGSVFIKESMFLPRSSFGKRSAGSLRRGCECIVLEPSEMIVV DYMDENEEYFQRQASHRQSRRRFRKINQKGERQTIIDTVDVNSYLNLPADFSRLHLADGL HPQVTHVSSSHSGCSITSDSGSSSLSDIYQATENEPGDMDLSGLPETAVDSEEDDDEEDI ERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRKQLCAVMVFA VVERAGTIVLNDGEELDSWSVILNGSVEVTYPDSRTEVLCMGNSFGVSPTMEKEYMKGVM KTKVDDCQFVCIAQQEYCCILNQVEKNMQRVEEEGEIVMVKEHRELDRTGTRKGHIVIKG TAERLTMHLVEEHSVVDPTYIEDFLLTYRTFLSSPMVVGKKLLEWFHDPSLRDKVTRVVL LWVNNHFNDFEGDPAMTRFLEEFENMLEKEKMCGHLRLLNIACAAKAKPRLVTLTKPSRD SPLGFSLLGGQEKGSRIFIDAVEPGSKAAEVGLKRGDQILEVNGQNFENVQLSKASEILK NNTHLSITVKTNLLVFKELLTRPEHDHDTDVEDDHDRKNGAPHQPKIGDIKKASRHSIPD LAVDVEQVMGLEKASKKAKANTVGGRNKLKKIFDKTLTSILPPKPYNDVCVGQSQDDSIL GMKQSKQIPPALPVSGNLSSSNPDLLQSHHRILDFNNQPDMSDQVLRVFKADQQSRYIMI GKDTTAKEVVVQAIREFALTAAPEAYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGR YYLKSNMETETLCSDEDAQDLLREGQISLLQLSTVEVATQLSMRAFELFCAIEPTEYIDD LFKRRSKTGSASLKRFEEAINHETFWVASEVTREPNQLKRMKIIKHFIKIALHCRECKNF SSMFAIISGLNLAPVSRLRGTWEKLPSKYEKLFGDLQDLFDPSRNMAKYRNVLNNQNLQP PIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIRHVGRMASVNMDPALMFRTR KKKWRSLGSLSQGSANAAVLDVNQTGGHKKRVRRSSFLNAKKLYEDAQMARKVKQYLSNL SLETNEESLQTLSLQCESSISTLPKNTGGKRPDTSPVVSRAASQQRGQLAKGNQALQVPA VALHPSRKRVPVKDLPPFGTSSPQSLKKILSLSEEGNERHRKPPEDTVSNASSQLSSPPT SPQSSPKKGYGRMGDAYSDSGHSEISSRSSLVSNSSFDMTQEERRLRHSGGVGEFHSGGP RMERRATTDADQYSLGSYSSMQDCRGIYAGCPTVLSSPSSEELTQDQGDRVSLDAADSGR GSWTSCSSGSHDNIQTMQQGRSWETLLLGGGSSGGSIGGPEILGGLGGHAALWAAQTRAS WASVSSSSSSAAYWGEDSEGDTGTIKRRGGKDVNADAETSSITSTGSEEAKLLSRPTPSP IPSGVSSKARKDGRYREPPPTPPGYTALTISDLSEGQHPRRRPPDYTTALQRSRMVTQSP DSHQAQQGSKHRGAGPQRTCSPAEGQEPEEEEEEGESMSAK >Homo sapiens_RAPGEF3(ENSP_395708) MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ FYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL PNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA YVQQLKVIDNQRELSRLSRELEP >Pan troglodytes_RAPGEF3(ENSPTRP_8316) MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ FYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG KVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSD FLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSML HTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWL PNQDEPLPGSSCAIRVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDL VSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMCRFNELQYWVAT ELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKV RKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFE KMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWA YVQQLKVIDNQRELSRLSRELEP >Gorilla gorilla_RAPGEF3(ENSGGOP_16046) MKVGWPGENCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLL EHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRK YHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQ FYRFPGPEPEPVGTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL VTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG KVVLVLERASQGAGPSRPPTPGRNRRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLS DFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSM LHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVW LPNQDEPLPGSSCAIRVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQ VLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLD LVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVA TELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHK VRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINF EKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTW AYVQQLKVIDNQRELSRLSRELEP >Macaca mulatta_RAPGEF3(ENSMMUP_0652) MVLRKMHRPRSCSYQLLLEHQPPSCIQGLRWTPLTNSEESLDFSESLEQASTERVFRAGR QLHRQLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDE GALCHVKHDWAFQDRDAQFYRFPGPEPEPVGAHEMEEELAEAVALLSQRGPDALLTVALR KPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTS WYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDF NRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLE AMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHQYPSSPTGMVEQERSTYICNKR QQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDARLSNLLREQWPERRRHHRLEN GCGNASPQMKARNLPVWLPNQDEPLPGSSCAIRVGDKVPYDICLPDHSVLTLQLPVTASV REVMAALAQEDGWTKEQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELT PHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIYYVLGPQHLRDVTTA NLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAQGRDREMTETDFSKKLGAP LSAVNFLSAWEAGSPVLACDRAWDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEG NHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQ SLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP >Mus musculus_RAPGEF3(ENSMUSP_116426) MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVF EHRRPSCIQGLRWTPLTNSEDSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRK YHLRLYRHCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQ FYRFPGPEPEPTGTQDVEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL VTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG KVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSD FLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQEHSTYICNKRQQILRLVGRWVALYS PMLHSDPVATSFLQKLSDLVSRDARLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAP VWLPNQEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTK GQVLVKVNSAGDVVGLQPDARGVATSLGLNERLFVVDPQEVHELTPHPEQLGPTLGSSEM LDLVSAKDLAGQLTDHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYW VATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLP HKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDVTFIHEGNHTLVENLI NFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQGSRISTCSEQSLSTRSPAS TWAYVQQLKVIDNQRELSRLSRELEP >Rattus norvegicus_RAPGEF3(ENSRNOP_61597) MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVF EHRRPSCIQGLRWTPLTNSEGSLDFRVSLEQATTEHVHKAGKLLYRHLLATYPTLIRDRK YHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQ FYRFPGPEPQPAGTHDVEEELVEAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEEL LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL VTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG KVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSD FLLTHSVFMPCTQLFAALLHHFHVEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYS PMLRSDPVATSFLQKLSDLVSRDTRLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAP VWFPNHEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTK GQVLVKVNSAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHELTPHPEQLGPTLGSSEM LDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYW VATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLP HKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLI NFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQASRISTCSEQSLSTRSPAS TWAYVQQLKVIDNQRELSRLSRELEP >Bos taurus_RAPGEF3(ENSBTAP_8976) MKVGWPGEGRWQVGLAVEGDSILGAPPLGGLPDVVPEGTLLNMVLRRMYRSRSCSYQLLL EHQRPSCIQGLRWTPLTSSEESLDFSVSLEQASAERVLRAGKQLHRHLLANCPNLIRDRK YHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWAFQDRDTQ FYRFPGPEPEPVGVHELEEELVEALALLSQRGPDALLTVALRKPPGQRTDEELDLIFEEL LHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGL VTTLHEGDDFGQLALVNDAPRAATIILGEDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHG KVVLVLERTSQGTGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSD FLLTHSVFMPTAQLCAALLHHFHAEPAGGSEQERSSYICNKRQQILRLVSQWVTLYGPTL RTDPVATSFLKKLSDLVSRDTRLSNLLREQWPERRRHHRLENGCGNVSPQMKARNVPVWL PSQDEPLPSSNCAIRVGDKVPYDICRPDHSMLTLQLPVTASVREVMAALAQEDGWTKGQV LVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELTPHPDQLGPTVGSAEGLDL VSTKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVAT ELCLCSVPGLRAQLLRKFIKLAAHLKEQKNLNSFFAIMFGLSNSAISRLAHTWERLPHKV RKLYSALERLLDPSWNHRVYRLALTKLSPPLIPFMPLLLKDMTFIHEGNHTLVENLINFE KMRMMARAARMLHHCRSHSNVPLSPLRSRVSHLHEDSQAVRVSTCSEQSLSTRSPASTWA YVQQLKVIDNQRELSRLSRELEP >Loxodonta Africana_RAPGEF3(ENSLAFP_12377) SQVGWPGESRWHLGLAVEASPALGASPAGGLPDVVPEGTLLNMVLRRMHRPRSCSYQLLL EHRSPSCIQGLRWTPLTDSEESLDFSVSLEQASTERVLRAGKQLHRHLLATCPNLIRDRK YHLRLYRQCCSGRELVDGILALGLGVHSRSQAVGVCQVLLDEGALSHVKHDWTFQDRDAQ FYRFPGLEPEPVGAHEMEEELVEAVSLLSQRGPDALLTVALRKPPGQRTDEELDLVIEEV LIEARGHLFNSVKRELAAVLLFEPHCKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKEGL GLEDGQLSSCDGGRPECVDHWVWLVLQDVEAKTMRLEEHGKVVLVLERTSQGAGPSCPPT PGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPSTQLCAALLH QYPPQPQAEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGPVLRTDPVATSFLQKLSDL VSQDARLSNLLKEQWPERRRHHRLENGYGNASPQMKARNMAVWLAGQDEPLPNSNCAIRA GDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDSWTKEQVLVKVNSAGDAIGLQPD ARGVATSLGLNERLFVVNPQEVHKLTPHPEQLGPTVGSAEGLDLVSAKDLAGQLTDHDWS LFNSIHQVELIHYVLGPQHLRTVTTANLERFMRRFNELQYWVATELCLCPVPGLRAQLLR KFIKLAAHLKEQKNLNSFFAVMFGLSNSAVSRLAHTWERLPHKVRKLYSALERLLDPSWN HRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCR GHSNVPLSPLRSRVSHLHEDSQASRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSR LSREMEP >Xenopus tropicalis_RAPGEF3(ENSXETP_9345) HIMDKAHRDRLAAYLFSSHFRLLQGTWHTPLPDIKSQEEYKQTVKQVVTHKVWRAAKVLH TYLLTVSPAMMRDRKHHFRSHRQCCSGKELVDWLLGISHGLQSRSQAVGIWQVLVDEGAL VHVRQEPNFHDKDSQFYRFVKAELHVDPLLTDKDTEEEVQESLVLLSQLGPAALLTMILR KPPCQRTEEELEVIFEELLHIKAVSHLSNSVKKELASVLIFESHAKAGTVLFNQGDKGTS WYIIWKGSVNVITHGKGLVATLHEGDDFGQLALVNDAPRAATIVLREDNCHFLRVDKHDF NRILRDVEANTVRLKEHGKVVLVLEKNPQISAGNNHQPAGASNQKYTVMSGTADKILEHL LETIKLDSCTEGIFLTDSFAGDFLLTHSIFMPTTQLCQALLHQFNVEPSEVNEPEKATYS LHKRQNILHLVSLWVALYGKLLEAEPSAKSFLEKLSEHVSRDPRLLAFWRENLQDRRKTR TLEVSSGNHSPQIKINSFGNLFSSLEEDASSNTYTIRAGDKVPYDIYRPDHSCITTMLPV NASVQEVISSLATKNGYNRDQIVVKVNSSGERVCLKHEDTGVFTSLGLNERIFICYNHEL NNVTPLPEQLGPNTSSSDILELISSKDLAHQMTDNDWNLFKSIHQVELIYHTFGKQRFRN ATTANLERFMRRFNEVQFWVATEVCLCQEEERRALLLKKFIKLAAYLKEQKNLNSFFAVM FGLSNTAVSRLSRTWQKLPNKFRKLYSIFERLMDPSWNHRSYRLAVAKLSAPLIPFLPLI LKDLTFLHEGNRSTLDSLVNFEKMRMIAKTVQMFHSCRSQAYIPLSPLRPRPVNILEDPS AARISACSEHSMTLRSPATTWAYIQHMKVIDNQKKLMELSRSLEP >Danio rerio_RAPGEF3(ENSDARP_98662) MEEIHARMFSFFKQILSAKKKNRLESPAVMCSADTLLRSTLRSSLQKTPLPDAVDTQDTI KQFLSDRILKAARVVYSTLMEGNPGLIRDRKHHLKTYRQCCSGKELVDWLMKLNDCFQSR SQAVGMWQVLVDEGILGHVKQELNFHDKDTQFYRFMEAEFDLNHTTNEKDSKDDELQESL SLLIQMGPDALLTMILRKCPSQRTPEDLEVIYEELLHVKAVAHLSTSVRKELASVLVFES HAKAGTVLFSQGDKGTSWYIIWRGSVNVITHGKGLVTTLHEGDDFGQLALVNDAPRAATI ILREDNCHFLRVDKQDFIRILKDVEANTVRLEEHGKVVLVLEKSSAQDTPSCNKYTVMSG TPEKILEHMLEAIKLETNGADFIDPCVTDFLLTHPVFMPCSQLCAALQHHYQAEPSEGSD LEKAAYALNTKQKVVKLVCHWVALFALLLRDDPVASEFLEKFREGVMADSRLSSMLREQL RDRRKTKIMENGCHTLTKLNQKFDWFSAYEEPVGKLRSIKAQDKVLYEIFKPDHKAVTVM LPVDASVNDILTTLVDPDRNYVLVKMNSSGDRVQLKLETTAVSASLGVNEKLFLCTSSQV EQLTPDKEQLGPEKSTMDTLEQICSKDMASQHTSYDWELFMAMHEVELVYYVFGREKFPG STTANLERFVRRFNEVQYWVVTELCLCEDLGKRAILLKKFIKMAVVLKEQKNLNSFFAVM FGLSNSAVQRLNKTWERLPNKTKRIYCAYERLMDPSRNHRAYRLTIAKLSPPYIPFMPLL LKDMTFIHEGNKNYTDKLVNFEKMRMIARTVKTVRDCRSQPYVPSSPQKGLTERMFLDAQ AIRISTYSDQSLNLRSATSIRQYIQNLKVIDNQKKLTQLSRALER >Takifugu rubripes_RAPGEF3(ENSTRUP_36942) EMHLFRSHQYQVFPDRLSVETPTIRGISWTPLPESLGSKDTMKQFLSDRVVKAARSVYSV MIEKNPGLIRDRKYHLKTYRQCCSGKELVDWLMKQSDCLQSRSQVVGMWQVLVDEGILVH VKQELNFHDKDTQFFRFRDSECGLNHVTNERDAEDELQEGLSLLSQLGPDALLTMILRKC PSQRSAEDLEVIYEELLHVKAAAHLSTSVRKELAAVLVFESHAKAGTVLFSQGDKGTSWY IIWKGSVNVITHGKGLVTTLHEGEDFGQLALLNDAPRAATIILREDNCHFLRVDKQDFIR ILKDVEANTVRLEEHGKTVLVLEKSSDRAEQTGAGSNSKYTVMSGTPEKILEHLLETIKL DSNGNDGIDPCVSDFLLTHKVFMSSSQLCSALLHQYPVAELSKGSDQEKASYILTAKRKV VKLVCHWVALYDLLLKEDPVALDFLERLKKEVAADYRLSGILKEQFRERRRTRILDNGYQ SLCRNINSTDTFLDCEEPVGRLQPIRAHDKVLYEICRADSKALTVMLPVNTTVQDVISAV VKPGGDHVLVKMNSAGERAQLKLDAAAVYTALGVNERLFICTSSQVEKLFPLKEQQGPER GTADILGQMGSKDIATELTNYDWELFAAMHEAELIYYVFGRHKFPGATTANLERFVRRFN EVQHWVVTELCLCEDLVKRAVLLKKFIKIASVLKEQKNLNSFFAVMFGLSNSAVRRLYKT WERIPSKTKRIYCSYERLMDPSRNHRAYRLTVAKLGPPYIPFMPLLLKDMTFINEGNPNY LEKLVNFEKMRMIAKTVKVVRGCRSHPYTPSSPQRSLADRMFLDGPTTRMSTCSEHGLLL RSPSNIRHYVQNLKVIDNQRKLTQLSRTLE >Tetraodon nigroviridis_RAPGEF3(ENSTNIP_15500) LGRMEMHLFRSYRYRVFPDRLSVETPTIRGISWTPLPESLDPKCSMKQFLSDRIVKAARS VYSVMVEKNPGLIRDRKHHLKTYRQCCSGKELVDWLLKQSECLQSRSQVVGMWQVLVDEG ILLHDKVKQELNFHDKDAQFYRFRDDGCSPNHVTNEREAEEELQEGLSLLAQLGPDALLT MILRKCPSQRSAEDLEVIYEELLHVKAAAHLSTSVRKELAAVLLFESHAKAGTVLFSQGD KGTSWYIIWKGSVNVITHGKGLVTTLHEGEDFGQLALLNDAPRAATIILREDNCHFLRVD KQDFIRILKDVEANTVRLEEHGKSVLVLEKSSDTAAADRSRQQLQVRYTVMSGTPEKILE HLLETVKLDSSGSDAVDACVSDFLLTHRVFMSSSQLCSALQLQYPDAEPSEGSDQDKASY VLATKQRVVKLVCHWVALYGLLLKDDPVALDFLEKLKKEVGADFRLSSIVKEQFRERRRT RILENGYQSLSRRQQNQNFDWFSHCEEPVGRLQPIRARDKVLWEISRPDGKALALMLPVD ASVQDVISAVGKPGGDQVLVRMNSAGERAELKLDAAAVFTALGVNERLFLCSSSQVEKLF PLKEQQGPERGTADILEQMSSKDVAAELTNYDWELFTAMHEVELIYYVFGRHKFPGAVTA NLERFVRRFNEVQHWVATDLCLCTDLVKRALLLKKFIKIAAVLKEQKNLNSFFAVMFGLS NSAVRRLHKTWERIPSKTKRVYCSYERLMDPSRNHRAYRLTVAKLGPPYIPLMPLLLKDM TFINEGNANHVDKLVNFEKMRLMARTVKVVRGCRSQPYTAPSSPQRSLADRVFLEGPATR MSTCSEHGLLRSPGNIRHYIQNLKVIDNQRQLTQLSRTLEC >Gasterosteus aculeatus_RAPGEF3(ENSGACP_14548) DEMHLFRSHNYRVYPDRSSVETPSIRGISWTPLPEALNSKDTMKQFLSDRVVKAARSVHS VMIDGNPGLIRDRKHHLKTYRQCSSGKELVDWLMKQNECLQSRSQAVGMWQVLVDEGILV HVKHELNFHDKETQFYRFQDSEFGLNHISNEKDSEEELQESLSLLSQLGPDALLTMILRK CPSQRSAEDLEVIYEELLHVKAVAHLSTSVRKELAAVLVFESHAKAGAVLFSQGEKGTSW YIIWKGSVNVITHGKGLVTTLHEGEDFGQLALLNDAPRSATIILREDNCHFLRVDKQDFI RILKDVEANTVRLEEHGKTVLVLEKRTEWAQQGGAGNSKYTVMSGTPEKILEHLLETIKL DSNGNDSIDPCVSDFLLTHKVFMSTSQLCAALQHQYPEAELSEGSEQEQASYILTTKQKV VKLIGQWVALYGLLLKEDPVALDSLERLKKEVAGDFRLFSILKEQFRERRRTKLLFYRSE NGYQTLSRNQPFDWFSNCEEPVGRLQPIRAKDKVLYEIYRPDNKPLTLMLPVNTSVKDVM SAIVKPGGDHILVKMNSMGERAQLKMDANAVYTALGLNERLFICTSSQAEKLMPLKEQQG PERGTTDLLEQMGSKDIANELTNYDWELFTAMHEVELVYYIFGLHKFPGAITANLERFVR RFNEVQYWVVTELCICEDLVKRAILLKKFIKIAAVLKEQKNLNSFFAVMFGLSNSAVHRL YKTWERIPSKIKRIYCAYERLMDPSRNHRAYRLAVAKLSPPYIPFMPLLLKDMTFINDGN PNYVDKLVNFEKVRMIAKTVKIVRGCRSQPYVPSSPQRGLADRMFLEGPSTRISTYSELA FPLRSPSSIRHYIQNLKVIDNQRKLTQLSRTIEC >Oryzias latipes_RAPGEF3(ENSORLP_19634) RLIEAGNLPSCGTFASFLYFFFSCKHLCVTNPSSSILTNGEHNISFEFVVSVQFLSDRVV KAARSVYSVMNEKNPGLIRDRKHHLKTHRQCCSGKELVDWLMKQNECLQSRSQAVGMWQV LVDEGILVHVKHELNFQDKEAQFYRFQDSDFGLSHIPNEKESEEELQEALALLSQLGPDA LLTMILRKTPSQRTPEDIEVIYEELLHVKAAAHLSTSVRKELAAVLVFESHAKAGTVLFS QGDKGTSWYIIWKGSVNVITHGKGIVTTLHEGEDFGQLALLNDAPRAATIILREDNCHFL RVDKQDFIRILKDVEANTVRLEEHGKTVLVLEQSTQSARQGSAGTNSKYTVMSGTPEKIL EHLLETIKLDSNGYDPIDPCVIDFLLTHKVFMPTSQLCPALQHQYPQMLDQAELSEGSEQ EKDAYIIDTKQKVVKLISHWVAVYGFLLKEDPVAMDFLEEQAMKKEVAADSRLSGMLKEQ YRERRRTKVLENGHHSLSRPLKQNQHFDWFSNCDEALGRIQPIKAKDKILYEIYRPDHKA LTLMLPVDSPVQDVLSGVVEPGGGHVLVKMNSTGDRAELKLEASAVYTALGLNERLFICT SSEVEHLRPLKEQQGPEQGTTDILEQIGSKDMAAELTNFDWELFTAVHEVELVYYIFGRN KFPGAITANLERFVRHFNKLQYWVVTELCLCEDLMKRALLLKKFIKIASVLKEQKNLNSF FAVMFGLSNSAVQRLYKTWERIPSKIKRIYCTYERLMDPSRNHRAYRLAVAKLNPPYIPF MPLLLKDMTFIHEGNPSYVDKLVNFEKMRMLAKTVNIVRGCRSQPYVPSSPQRGLADRMF LEGPATRLSTYSDHSLPQRSPTNIRLYIQNLKVIDNQRQLTQRSRALEC >Homo sapiens_RAPGEF4(ENSP_380271) MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Gorilla gorilla_RAPGEF4(ENSGGOP_8927) MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFSTGDERAQK RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVATFELMSSKDLAYQM TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Mus musculus_RAPGEF4(ENSMUSP_88336) MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Rattus norvegicus_RAPGEF4(ENSRNOP_10630) PNKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQ CCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEH EDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTADDLEIIYDELLHI KALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCT LHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDV LVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFV MMHCVFMPNTQLCPALVAQYPFPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQED DVAMAFLEEFYVSVSDDARMMVAFKEQLAELEKTVKQISEDAKAPQKKHKVLLQQFNTGD ERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMN SGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKD LAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCS QLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAE FESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIA NTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Bos taurus_RAPGEF4(ENSBTAP_53320) MVAAHAAHSSSSAEWIACLDKKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCG YYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILD NTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDTFPSKEQ TPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGT ELVDWMLQQTPCVHSRTQAVGMWQVLVEDSVLNHVDQEHHFQDKYLFYRFLDDEHEDAPL PTEEEKKECDEELQDTMLLLSQMGPDAHMRMVLRKPPGQRTMDDLEIIYEELLHIKALSH LSTTVKRELAAVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGD DFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEK VPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCV FMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDILQEDDVAM AFLEEFYVSVSDDARMLAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQ KRQPIRGSDEVLFKVYCVDHTYTTIRVPVAASVKEVLSAVADKLGSGEGLIIVKMSSGGE KVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTMGTFELMSSKDLAYQ MTIYDWELFNCVHELELIYHTFGRHHFKKTTANLDLFLRRFNEIQFWVVTEICLCSQPSK RVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESL MDPSRNHRAYRLTVAKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTAR TVRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Loxodonta Africana_RAPGEF4(ENSLAFP_8236) MVAAHAAHSSSSTEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT PLIEPHVPLRPANTITKVPSEKILRAGKILRNVILSRAPHMIRDRKYHLKTYRQCCVGTE LVDWMMQQTQCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV PAGNRASNQGNSQSQQKYTVMSGTPEKILEHFLETIRLEPALNEATDSVLNDFVMMHCVF MPNTQLCPALVAHYHAQPSQGTEQEKMDYTLNNKKRVIRLVLQWAATYGDLLQEDDVAMA FLEEFYVSVSDDARMIAALKEQLPDLEKIVKQILEEAKAPQKKHKVLLQQFNTGDERAQK RQPIRGSDEVLFKVYCMDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMSSGGEK VLLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFTDNLVNFEKMRMIANTART VRYCRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP >Monodelphis domestica_RAPGEF4(ENSMODP_11330) MVAGHAAHFSSSAEGIPCRDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN TPRHATIVTRECSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETSANNDRHFIFQTP LIEPHVPLRPAKTITQVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTEL VDWMIQQTPCVHSRAQAVGMWQVLLEEGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPT EEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELIHIKALSHLS TTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDF GKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVP AGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETVRLEQPLNEVTDSVLNDFIMMHCVFM PNSQLCPALVAQYPFIPSQGTEQDKMDYALNNKRRVIRLVLQWAALYGDLLQEDEVAMAF LEEFYVSVSDDSRMIAALKDQLPELEKMVKQISEDAKAPQKKHKVLLQQFNPVEDRAQKR QPVRGSDEILFKVYCLDHTYTTIRVPVSASVKEVISAIADKLGSGEGMIIVKMSSGGEKV VLKPNDVSVFTTLTVNGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMT IYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCAQLSKRV QLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKIYAEFESLMD PSRNHRAYRLTVTKLDPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTVRTV RYCRSQTFNPDAALANKNHQDVRGYVRQLNVIDNQRTLSQMSHRLEPRR >Gallus gallus_RAPGEF4(ENSGALP_10246) GRGEPPPPPAGCAATSSLSNMVAAHTSHSASSGEWIACLDKRPLERSSEDVDIIFTRLKE VKAFEKFHPNLLQQICLCGYYENLEKGITLFRQGDIGSNWYAVLTGSLDVKVSDTSNHQD AVTICTLGIGTAFGESILDNTPRHATIVTREYSELLRIEQKDFKALWEKYRQYMSGLLTP PYGVMETGSNNDRMPDKKNTPLIDSHIPHRPSKTITQVPSEKILRAGKILRNTILSRAPH MIRDRKYHLKTYRQCCVGTELVDWMMQQSTCVHSRSQAVGMWQVLLEEGVLNHVDQEHHF QDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQIGPDAHMRMILRKPPGQRS IDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHPKAGTVLFNQGEEGTSWYIILKG SVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDV EANTVRLKEHDQDVLVLEKIPAGNRVSNQGSSQPQHKYIVMSGTPEKILEHFLETMRLEA TLNEATDSVLNDFIMMHCVFMPNSQLCPALMAHHGTYHAQPSQGTEQEKMDYALNNKRRV IRLVLQWAALYGDLLQEDEAAMAFLEEFYVSVSDDTRMIAALKEQLPELEKIVKQVAEEP KAPQKKHKVLLQLFNTSDDRAQKRQPIRGSDEVLFKVYCIDQTYTTIRVPVSSSVKEVIS AVADKLGSGEGLIIVKMSSGGEKVVLKPHDVSVFTTLSVNGRLFACPRDQFDSLAPLPEQ EGPSAGTVGTFELMSSKDLAHQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFL RRFNEIQFWVVTEICLCSQLSKRVQLLKKYIKIAAHCKEYKNLNSFFAIIMGLSNVAVSR LSLTWEKLPSKFKKIYAEFESLMDPSRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTHEG NKTLTDNLVNFEKMRMIANTVRTVKFCRSQSFNPDAALANKNHQDVRSYVRQLNVIDNQR TLSQMSHRLEPRRA >Xenopus tropicalis_RAPGEF4(ENSXETP_16383) PIMVAAHTAHSTSSAEWIACLDKRPLERSGEDVDIIFARLKEVKAFERFHPNLLQQICFC GYYENLEKGITLYRQGDIGTSWYAVLTGSLDVKVSETNNHQDAVVICTLGVGTAFGESIL DNTPRHATIVTRENSELLRIEQKDFKTLWEKYRQYMAGFLAPPYGVLETGSNDSKLSDKE NTPLIENQIPIRPAKTITEVPSERILRAGKTLRNAILTRAPHMIRDRKYHLKTYRQCCVG TELVDWLMQQSSCVHSRTQAVGMWQVLLEDGVLNHVDQEYYFQDKYLFYRFLDDEHEDAP MPTEEEKKESDEELQDTLLLLSQIGPDAHMRMILRKPPGQRSADDLEIIFEELIHIKALS HLSTTVSPFLELHCILKKKVFQSRRSTKIIIFNQGEEGTSWYIILKGSVNVVIYGKGVVC TLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQD VLVLEKILAGSQGSAQGNTQSPYKYTVMSGNPEKLLEHFLETMRLDPSLNDATADTALDD FILMHCVFMPNSQLCPALMSQYHAQPSQGTEQEKLDYTLNNKRRVIRLVQQWATLYGDLL REDEVSMAFLEHFHKGTNAKIESKKLVAALSRDLQKIKRLIMNISEDAKGQQKKHKVLLR QFSTGDERLQKRQAIRSSDELLFKVYCIDHTYTTIRVAVAASVKEVLSAVADKLGSGDSL ILVKISSAGEKVVLKPNEISVFTTLSVNGRLFACPRDQFDSLTPLPEQEGPSAGTMSTFE LMSSKDLAYQMTIHDWDLFSCVHELELIYHTFGRQNFKKTTANLDLFLRRFNEIQFWVVT EICLCPQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLSLTWEKLPSKF KKIYAEFENLMDPSRNHRAYRLTVAKLDPPIIPFTPLLIKDMTFTHEGNKTFIDNLVNFE KMRMIANTLRTIRYCRSVPFNPDASLAGKNHQDVRNYVRQFNVIDNQRTLSQMSHRLEPR RA >Danio rerio_RAPGEF4(ENSDARP_114027) MISPKMVAAHTSSHPSASADWIVCLDKRPEERSGEDVDIIMVRLKSVKAFEKFHPPLLQQ ICLCGFYECLEKGITLYRQGDIGTNWYTVLSGSLDVKVSETANHQDAVTICTLGIGTAFG ESILDNTPRHATIVTREFSELLRIEQKDFRNLWENYRQCMAGLLVPPYGVMDSGPNADRM PDKENLSNSSPGLSPKHLNKVPSEKILRAGKVLRNIILSRAPHMIRDRKYHLKTYRRSCI GTELVDWLLQHTSCVHSRVQAVGMWQVLLEEGVLNHVDQEPTFQDKYLFYRFLDDESEDS GMPSEEDKKESDEELQDTLLLLSQIGPDAHLRMILRKQPGQRTVDDLEIIYEELLHIKAL SHLSTTVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHE GDDFGKLALVNDAPRAASIVLREDFCHFLRVDKEDFNRILRDVEANTVRLKEHEEDVLVL EKANNRSSSSSPLKYTVMSGTPEKILEHLLETMKLDCQFSESDPALDDFLLMHCVFVPNS QLCPLLMTQYPSLIKPYCFSTKTPHQASQGSEQERMDYTLNNKRRVVRLVLQWASINTDH LQEEDSSFSFIQEFYEMVCEDSRLTPALKDHLPELEKIIKQNSDDGRPSQKKHKVLLRQF STGNDRLQKRQPIKSTDENKELLKPSDVSIFSSLSINGRLFVCPRDQIDSLTPLPEQEGP SAGSMSTFELMSSKDLAHQMTLYDWELFHCVHEHELIYHTFGRHHFKKTTANLDLFLRRF NEVQLWVVTEVCLCPALSKRVQLLKKFIKIAAHCKEFKNLNSFFAIIMGLGNPAVCRLSQ TWEKLPSKFKKFYGEFENLMDPSRNHRAYRLTMAKLEPPIIPFMPLLIKDMTFTHEGNKT FTDRLVNFEKMRMIANTVRIIRYCRSQPFDQEAPQATGKSHQDVRTYVRHISVIDNQRSL SQLSHRLEPRRT >Takifugu rubripes_RAPGEF4(ENSTRUP_45217) MVAAHPSSHSSESAQWIICLDKRPAERSGEDVDIILARLKKAKAFEHFHPSLLHQICLCG FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSYHQDAVVICTLGTGTAFGESILD NTPRRATIVTREFTELLRIEQREFRCLWERYHHCMAGLLVPSYGVMESACSADRMPNKEN VSDNPFVSIGKHQNKVPSEDILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELV DWQMQQSSCVRSRLQAVGMWQVLLEEGVLNHVDQELSFQDKYLFYRFLDDEQEDALFPSE EERRESQEELQDTLLLLSKIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST TVKRELAGVLIFESHAKAGTVLFSQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG KLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHGQDVLVLERSLG NSRSSIHGASSSQYKYTIMSGTPEKILEHLLEMMRLDSQFTESADSALDDFVLTHPVFIP NSQLCPVLMAHYHAQASQGCEQERMDYTLNNKRRVIRLVMRWAAVHGDHLLEEEDVVAFL QEFLVAVSNDAKVLPALREQLAKLEITVKHYTEDARISRKKHKVFLRQFSTGEEKLQKRQ PIKSNDEILFKVYCCDNTYTTIRAPVAASVRELISSLAEKLGSTEDLLLVSLGSAGEKVI FKPNDVSVFSTLSINGRLFVCRRDELDSLTPLPEQVEPSAGLSSNFELMSSKDVACHMTS YDWELFNCVHELELIYHTFGRQNIQKTTVNLDLFLRRFNEIQFWVITEMCLCSQLSKRVQ LLKKFIKIAAHCKEYKNLNGFFAITMGLSNPAVCRLNMTWEKLPSKFRKFYREFENLMDP SRNHRAYRLTVAKLDPPIIPFMPLLIKDMTFTQEGNKTFIDTLVNFEKMRMIANTVKILR YCRSQPFSPDSPQAGKSHSDVRAYVRQFNVIDNQRTLSQLSHSLEPPRS >Tetraodon nigroviridis_RAPGEF4(ENSTNIP_20064) MVVAHASSHPSESAEWIICLDKRPAERSGEDVDIILARLRRVKALERFHPSVLQQICRCG FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSYHQDAVVICTLGTGTAFGESILD NTPRHATIVTRECTELLRIEQRAFRSLWERYHHCMAGLLVPPYGVMESACSADRMPNTEN ISDDAFVSADKHQNKVPSENVLRAGKILRNAILSGAPHMIRDRKYHLKTYRRCCVGTELV DWQMQQSSCVRSRVQAVGMWQVLLEEGVLSQVDQELSFQDKYLFYRFLDDEQEDAPFPSE EEERESQEELQDALLLLSQIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST TVKRQLAGVLIFESHTKAGTVLFSQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG KLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHGQDVLVLERSLG NSRTSVHGASSSQYKYTIMSGTPEKILEHLLEMMRLDSQFTESADSALDDFLLTHPVFIP NSQLCPVLMAHYHAQASQGCEQERMDYTLNNKRRVIRLVMQWAALHGDHLQDEEDSVVFL QEFLVAVSNDAKVLPALRDQLAKLETTVKHYAEDARVSQKKHKVFLRQFSTGEEKLQKRQ PIRSNDEILFKVYCCDNTYTTIRASVAASVRELMGALAEKLGSAEDLLLVSLGSAGEKVI FKPNDVSVFSTLGINGRLFVCRRDELDSLSPLPEQVEPSAGLSSNFELMSSKDVACHMTS YDWELFSCVHEFELIYHTFGRQNFRKTTVNLDLFLRRFNEIQFWVITEMCLCSPLSKRVQ LLKKFIKIAAHCKDYRNLNGFFAVTMGLSNPAVGRLSLTWEKLPSKFRKFYREFENLMDP SRNHRAYRLTAAKLDPPIIPFMPLLIKDMTFAHEGNKTFVDNLVNFEKMRMIANTVKILR HCRSQAFSPDSPPAGKNHSDVRAYVRQFNVIDNQRTLTQLSHGLEPPRP >Gasterosteus aculeatus_RAPGEF4(ENSGACP_6371) MVAARTSSHSSESVEWIICLDKRPAERSGEDVDIILARLKNVKAFERFPPILLQQICLCG FYECLEKGITLYRQGDIGTSWYAVLSGSLDVKVSETSSYQDAVTICTLGAGTAFGESILD NTPRHATIVTREFSELLRIEQREFRSLWEKYHQCMAGLLAPPYGVMESGCSGDTMPDKEN ISNNSFVSVSKHQNKVPSEKILRAGRILRNAILSGAPHMIRDRKYHLKTYRRCCVGTELV DWQIQQSSCIHSRVQAVGLWQVLLEEGVLNHVDQELSFQDKYLFYRFLDDEQEDAPLPGE AEGKESQEELQDTLLLLSQIGPDAHMRMILRKHPSERTADDLEIIYEELLHIKALSHLST TVKRELAGVLIFESHAKAGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFG KLALVNDAPRAASIVLREDNCHFLTVDKEDFNRILRDVEANTVRLKEHGQDVLVLEKSLG SSRASTHGASSSHYKYKVISGTPEKILEHLLEMMRLDSQFTESADSALDDFVLTHCVFIP NGQLCPVLMAHYHAEALQGSEQEKRDYTLNNKRRVIRLVMQWAAVHRDHLQEEDTSVAFL EEFVTAVSNDVKALPALGDQLTELERSLKRNTDDARVSKKKHKVLLRQFSMGDEKLQKRQ PIKSNDEILLKVYCCDHTYTTIRVPVGASVREVVGAVADKLGSAEDLLLVGLSSAGEKVI FKPNDVSVFSTLSINARLFACRRDQLDSLTPLPEQEGSSTGPLASFELMSSKDVAYHMTS YDWELFHCVHELELLYHTFGRQNLKKTTVNLDLFLRRFNEIQFWVITEMCLCSQLSKRVQ LLKKFIKIAAQSCKEYRNLNAFFAVIMGLSNPAVCRLSQTWEKLPSKFKRFYGEFENLMD PSRNHRAYRLTVAKLEPPIIPFMPLLIKADMTFTHEGNRTFIDYLVNFEKMRMIANTLKI VRYCRSQAFSPDSTQASKNQAEVRTYVRQFKVIDNQRTLSQLSHRLEPRRS >Oryzias latipes_RAPGEF4(ENSORLP_21824) MVAARTSAHSSQTADWINSLDKRPEERSSEDVDIILARLKKVKAFKGFNPSLLQQICLCG FYEGLEKGIMLYRQGDIGTSWYTVLSGSLDVKVSETSSYQDGVTICTLGTGTAFGESILD NTPRHATIVTREFSELLRIEQKEFRSLWEKFYYCMAGLLVPPYGVMESTCGSDRIPDKEN IPFVPLSKHPNKVGNSIFPTLSEKILHAGKILRNAILSKAPHMIRDRKFHLKTYRQCCVG TELVDWLMQQSSCVHSRPQAVGMWQVLLEEGVLNHVEQEMNFQDKYLFYRFLEDEREDAP LPSEEEKGESQEELQEALLFLSQTGPDAHLRMILRKPSSDRAADDLEIIYEELLNIKALS HLSTTVKRELAGVLIFESHAKAGTVLFNQGDEGTSWYIILKGSVDVVIYGKGVVCTLHEG DDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLEEHGQDVLVLE KTLGSARNSADGSSAVHYKYRVMSGTPEKILEHLLKMMRLDLQFTESVTDSALDDFVLMH CVFVPNSQLCPLLRAHYHAQASQGSEQEKLDYALNNKRRVICMIMKWATVHDDQLQQEDV AFLQESLISASNDATWLPALGDQLTELERVVKRCAEAAMASQKKHKVFLRQFSLGEEKPQ KRQPIRGSDEILFKVYCCDHTYTTIRVPVAASVQEVISAVADKLGSVEELNLVHLSSAGE KTIFKPNDVSVFSTLSVNGRLFACRRDQLDSLTPLSEQGGPSSGSLSSFELMSSKDVAYH LTSYDWELFHCVHELELIYHTFGRQHINKTSVNLDLFLRRFNEIQFWVITEICLCSQISK RVQLLKKFIKIAAHCKDYKNLNAFFAIIMGLSNPAVSRLSQTWEKLPSKFKKFYGEFENL MDPSRNHRSYRLIFSKLEPPVIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIAKTVK IVRYCRSQTFSEDAPLPSKHHPDVWTYVRQFNVIDNQRILTQLSHGLEPRRS >Homo sapiens_RAPGEF5(ENSP_343656) MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQ LVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEEN NDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQ DDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHL EEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHL VSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDE YSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILK VVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAE NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG NKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALF ELSHRIEPRV >Pan troglodytes_RAPGEF5(ENSPTRP_56753) MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQ LVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEEN NDKRVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQ DDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHL EEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHL VSQWIALYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDE YSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILK VVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAE NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG NKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALF ELSHRIEPRV >Gorilla gorilla_RAPGEF5(ENSGGOP_20894) LLEADCDTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRVNLKGFYR RSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDE CSYLYCEFEREEEWQNGVKLLLQLVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAV QRELAAVIALKARKSAIEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQ KLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESH WRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRMGR HSICTYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKTIYRNVL DDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET EEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGDKEKHELQ PNDLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDW SLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVK KFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLN HKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCR TNQFGSDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV >Mus musculus_RAPGEF5(ENSMUSP_105313) MTTGDCQTLSRRISNPYLEHSPSQIYGENSSCAGRALRNIIILQAADLVKDRVNLKGFYR RSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMSSVDQHLYFQDNYVFYQFSSDE CSYLYCEFEREEEWQKGVKLLLELVHLIPARAGICDLSHQKTEDSEESSDEILARLTSAV QRELAAVIALKARKSAIEQDDENADKHVTVTEANNGPDPQAGVMCKLQERDDIGRIELVH KLARENCQFLQTEKKESEKLEQQDDEVTMVQVKEQGQSVLVLKKVASCGPAPTSGSAEND ARYVVVSGTPEKILEHLLNDLHLAEVQHKETETLLDDFLLTYTVFMTTDDLCQALLRHYS AKKYQGEEENSDVPCRKRKVLHLVSQWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYP ILEKELKEFQKILGVYRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHV YITEHSYISVKAKVSSTAQEILKVVAEKLQRAEEDLALVAITFSGEKHEFQPNDLAISKS LEASGRIYVYRKDLADTLNPLAENEESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQ ELIYFTFSRQGNGENTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHC KAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFK KMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDVS PKEQQELKSYVNHLYVIDSQQALFELSHRLEPRA >Rattus norvegicus_RAPGEF5(ENSRNOP_7112) TLSRRISNPYLDHSPSQIYGENSSCAGRALRNIIILQAADLVKDRVNLKGFYRRSCVGSE LVDWLLEHCPFVQCRSMAIGVWQLLLDMGIMSSVDQHLYFQDNYVFYQFSSDECSYLYCE FEREEEWQKGVKLLLELVHLIPARAGICDLSHQKAEDSEESSDEILARLTSAVQRELAAV IALKARKSAIEQDDENTDKHVTVTEANDDAPDPQAGVMCKLQERDDIGRIELVHKLAREN CQFLQTDKKEPEKSEQQDDEVTMVQVKDQGQSVLVLKKVASCGPAPTTGSAESDARYVVV SGTPEKILEHLLNDLHLAEVQHKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQG EEENSDVPCRKRKVLHLVSQWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKEL KEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYVTEHS YISVKAKVSSTAQEILKVVAEKLQRAEEDLALVAIMFSGEKHEFQPNDLAISKSLEASGR IYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFT FSRQGSGEHTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQQNL NSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPK IPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDMSPKEQQE LKSYVNHLYVIDSQQALFELSHRLEPRA >Bos taurus_RAPGEF5(ENSBTAP_33741) WGSGPCQTLSRRISNPYLEHTPSQIYGENSSCAGRALRNIIIVQAADLIKDRANLKGFYR RSCVGSELVDWLLEHCPFVQCRSMAIGVWQLLLDMGILSSVDQHLYFQDTYVFYQFSSEE CSYLYCEFEREEEWQNGVRLLLQLVPLIPSRAGICELSHQKIEDSEESSDEILARLTSAV QRELAAVIALKARKSALAQDEENSDKHVTVTEAEAAADPQAGMMCKLQERDDIGRIELVQ KLARESCQFLQTDKKEQEKSEHQLKQDDEVTTVEVKEQDQNVLVLKKVQSCGPAPQAGSA ESDWRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLR IYSAKKYQGKEENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKTIYRNVLDDVY EYPILEKELKEFQKILGMHRRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTESEEIF CHVYITEHSYVSVKATVSSTAQEILRVVAEKIQHAEDDLALVAVTFSGDKEKHELQPNNL AISKSLDASGRIYVYRKDLADTLNPFAENEESQQRSIRILGMNTWDLALELMNFDWSLFS SIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSPLGKRVQLVKKFIK IAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAY RDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQF GGDISPKEHPELKSYVHHLYVIDSQQALFELSHRIEPRV >Loxodonta Africana_RAPGEF5(ENSLAFP_12495) TLSRRISNPYLDHTPSQIYGESSSCAGKALRNIIIVQAADLIKDRVNLKGFYRRSCVGSE LVDWLLEHCPFVQCRSMAVGVWQLLLDMGIMLSVDRHLHFQDTYVFYQFSSDECSCLYCE FEREEEWQNGVKLLLHLVPLIPARSGICELSHQKIEDAEETSDEILARLTSAVQRELAAV IALKARKSAIEQDEENSDKHIAVPEAEGVPQSQAGVMCKLQERDDIGRIELVQKLARENC QLLQTDKKELEKSEHQDDEVTTVQVKEQDQNVLVLKKVPGGGPAPTSGSTENDWRYVVVS GTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGK EENSDVPCRKRKVLHLVSQWIALYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELK EFQKILGMHRRHTVDEYSPQRKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSY VSVKAKVSTTAQEVLKIVAEKIQHAEEDLALVAVTFSGDKHELQPNDFAISKSLEASSRI YVYRKDLADTLNPFAESEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTF SRQGSGEHTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLN SFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKI PFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGGDVSPKEHQEL KSYVNHLYVIDSQQALFELSHRIEPRA >Monodelphis domestica_RAPGEF5(ENSMODP_1532) LPTFDVPYFKYIDEEDEEDEWSNRSQSSTEDESSDSLLSDRYVVVSGTPEKILEHLLNDL HLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALPPQHWPHGPAHLFSLTLRTYSAKKYH GREETCDIPRRKRKVLHLVSQWIGLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPVLEKE LKELQKMLGLHRRHTVDEYSPHRKNKALFHQFSLKENWLQHRGTVGETEEIVVCHVSLVN DSDPNMYVSVRDAAMSTGFLPVSRLCSHSVSFDFLKEKHELQPNDLAISKSLELSGRIYV YRKDLSETLSPLVESEESQQRSLRILGMNTWDLAMELMNFDWSLFNSIHEQELIYFTFSR PGSSENTVNLSLLLQRCNEVQLWVATEILLCSQLCKRVQLVKKFIKIAAHCKAQRNLNSF FAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPF MPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRSLRHCRNSHFGGDVSPKEHQELRS YVHHLHVIDNQQVLFELSHRIEPRA >Gallus gallus_RAPGEF5(ENSGALP_17724) QTVLQTLSRRISNPYLETPSNKIYGESSSCAGRALRNIFTLQASDLIKDRVYLTGICRRS CVGSELVDWLLEHCPFVKCRSTAVGVWQLLLDMGIILSVDRELYFRDTYTFYQFSADECT YLFCEFEKEGGWKNAVKLLLQLLPLSPPRIDVCNLPDQKIEDTAETNAEILARLTSAVQR ELAAVIALKARKSAIHQNEENSSQEIRGLEELKTASDAQAGVLCKLQERDDIGRIELVQK LARENCQFLQADRKQPEKTDQNKEEEVTLCQVARESKKEIPRKNIARCKQAAPTRGCETE DCRYVVVSGTPEKILEHLLSDLHLEAAQDKETETLLDDFLLTYTVFMTTDDLCQALLSTY CAKNHQGKEDDSDVSCRKRKVLHLVSQWTSLYKDWLHEDEHLKQFLKTIYRNVLDDVYEY PILEKELKEFQKILGMHRRHTVDEYSPHRKNKTFFHQFSLKENWLQHRGTMNEAEEIFCR VYITEHSYVSVKAQVTTSAQEIVKIVAEKIQYPEEELALVIITFSGEKHELQPNDLAISK SYESSSRMFVYRRDLTDSLNPFAENEELQQRSVRILGINTWDLALELTTFDWSLFNAIHE QELIYFTFSRQGSAENTENLSLLLQRCNEVQLWVATEILLCSQLCKRVQLVKKFIKIAAH CKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFTELESLTDPSLNHKAYRDAF KKMKSPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRSLRHCRNNQFGNEV PSKEHHELKPYIHHLHVIDNQQALFELSHRIEPRA >Xenopus tropicalis_RAPGEF5(ENSXETP_16124) MHFFQCFSLSTKRIPSLYVDNSATKLYGESVSCAGRALRNAVRSQTPELIRDRMYLTCIC RKSCVGSELVDWLLQHCPFVQCRYTAASIWQILLKLGILLSVDKQLCFQDTYVFYQFSSE ECGDAGCEFGRDKGWLMGVRLLKQLAPLVPLTSNMCDVSADKLDHSNEANNKVLQIQALA RLTSAVQRELAAVIALKARKSAIGQNSWTGSKQSTCQESQVPPLPQAGVMCKLHGREEFR RIDFVQKLKRETNCICLRSSNNEADYIWKQDEEESTVQVKEEDQDVLVLKKVLSESPAPT AGSAENDWRYMVVSGTPEKILEHLLNDLHLDEVQDKDTDTLLDDFLLTYTVFMTTDDLCK ALLRQYPSETKYEGKAESPEALCTKRKVLLLASQWTALYKDWLHEDEHSKLFLKTLYRYV LDDVYEYPILEKELKEFQKVLRIHRRHTVDEYSPHRKNKALFHQFSLKENWLQHRGNANE IEEIFCRVYITDHSYVSIRAKVSSSAQDILKTVAERIQLSEEDLALVTVTYCGEKQELLP NELVLSKSLEPSSRIYTYRKSDTLNPFAENEETQHRSVRLLGINTWDIAFELTSFDWSLF NSIHEQELIYFTFSRQGKGENTLNLSLLLQRCNEVQLWVATEILLCNQPGKRVQLLKKFI KIAAHCKAQRNLNSFFAIIMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKA YRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADAVRSVRYCRNNQ FGNDLPQKERQEAKFYSNHLHVIDNQQTLFELSHRIEPRV >Danio rerio_RAPGEF5a(ENSDARP_100132) MELVNESPSFKDLVCKVLEVHKSRTDPPRLLKNGSQFKKNLEVIISQKPPPDSILCSNAG QTRHQACVNNVPCAGQALRNAVLSNCQDNWKTHVKLAKIIRRTYIGIELVEWLMDHCEFI QNREIASKIWNVLLDLGILLSVEQNNIFEDSRSLYQFTFKECEAQSCDFRNQVNWRSAVH LLLQLVPHEQLCGGTQRRCKEDKQKTPDACNPVLQMRALEHFTSTVQNELLAALARKAQT KSMEEDSNPQHNTDTPGSSSTPAVLKQVPGAGTRDREEISRLEMVQRLAKDGCRLLHSPL RVNERPAEPLGDAAVRVCERSHEVLLPKRTTSLKSPSSSSSSWSRRYAAVPASPEKVLEH VLGQLRLDEEQKSLQSRETDSLLDDFLLTYPVFMSTSDLCQALLGHYCSKKGRMKEEWRE SLLRKRKVLHLLSQWSSLCTELPQDDDNTKLFLKTLYRHVLDDLYEFPPLEKDLKELQKL LRMQRRHTVDEYSPQRKNKALFHQLSLKESWHPMRGPERERKEVLCRVYVTVDSYVSVRT HSEVCVQELLRAVAERLDCAEDDMVLMALTYPGEKVVLELDQCVFSSSLSAAERLHVFRR DLTEIMSPFTDNGQQCSGKMLSMNTWDVSVSLTNCDWSLFSNIHEQELVYFTLSRDSSSG HTVALEQLLQRCNETQQWVMTEVLLCSTLCKRVQLFKKFIKIAAHCKAQRNLNSLFAIIL GLNSPAVSRLTQTWEKVPGKFRKLFSELESLTDPSLNHKAYRDAFRKMKSPKIPFLPLLL KDITFIHEGNKTFLDNLVNFDKLHMIADTVRIIRQCRTDHMGNLLFQKDSMEVRTYINYL HLIDNQQTLFELSHRLEPKT >Danio rerio_RAPGEF5b(ENSDARP_103378) MKTLYRYVLEDVYEFPTLEKDLKEFQKLLRRRHTVDDYSPHQKNKALYQQLSLKENSVSL RASPVESRDVMCRVYVSCDSYLSMRVKPAVVAQELLHIVSQRMDRCEDDMMLLAQTYSGE KRVLQPHDSIYSESLVAPGRLIACRRDLSEILPPLTECPDLGQKPVRLLGINTWDVAVAL TNFDWNLFNSIHEQELIFYTFSRQASSGHTVALEFLLQRCNEVQQWVMSEVLLCPSLSKR VQLLKKFIKIAAHCKAQRNLNSSFAIIMGLNTAAVSRLNQTWEKVPGKFKKLFSELELLT DPSMNHKAYRDAFKKMKPPKIPFMPLLLKDITFIHEGNKTFHDNLVNFEKLHMIADTVRL IRHCQMDQTGNELSAVDSAEVRSSVHYLHIIDNQQTLFELSHRLEPRV >Takifugu rubripes_RAPGEF5a(ENSTRUP_40407) MCILHDKEDLSRLEMVQRLAKDGCRFLQNHSKGPERPSEKSDEVIRVCLRERGHSVLVLQ RMSSEQPTPAASSGAEREEARDRRFVVVSGTPEKILEHLLDDLTLEEDQGTTHGNESDTL LDDFLLTYPVFMSTGDLCQALLGQYPYKRKVKEDGREALERKRKVLFLVSQWMELCNDFL RDDERVKHFMKTLCSYVLDDLYEHPALEKDVRELQRLYMLHRRHTTDEYSPQRKSKALFH QLSLRDNGLQSRGLLRENKEALCHVYITMDSFLSMRVHAGVTAQELLQAVEERMDVPQGD LLLVAVTYPGGRLLLQPQDRIFSDCLRPIGRLHVCKKDLGEILNPFTDNSELHQRTARML TLNTWDVAVALTQLDWAIFHSVHEQDLVYFTFSRHSSSSSSSSSSRTVGLELLLQRCNEV QLWVMTEVLLCPLLCKRVRLIKKFIKIAAHCKAQKNLNCFFAIIMGLNTAAISRLSQTWE KIPGKFKKLFSELEAITDPSLNHKAYRDSFKKMKAPKIPFLPLLLKDITFIHEGNKTFHD NLVNFEKLHMIADAVRFLRQCQRDHMGNGIIQKSSSEARAHIDYLHVIDNQQTLFELSHR LEPRT >Takifugu rubripes_RAPGEF5b(ENSTRUP_21305) CAGRSVRNAFLSHGPYPAKDKIHLARIIRRSYVGVELVQWLCEQCVYVRCRTTAVRVWQV LLELGVLLSVDQRVIFSDSNTYYQFSFEECDSPSCEFRSNEGEWPEAVRLLLQLAPYVQF RSGGGANSPSQSHDSTLTGIATRAKLVCIVQSELAAALARKTRKALSEQDSETMELSGVC TLRGGGGGGGGGIGTCNREELTSRLGLETVQRLAKDGCRLLQNHNHRLSDKNQADEALGR VCLKERGRDVLVLQRVKSSVTSPSDRPSPTSSGGGSREDDCDKRYVVVSGTPLKILEHLL SDLRLDDQRGAPESRESEMLLDDFLLTYLVFMTTHDLCQALLGTYSSTRCRGQEEGKDAL FRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKTLYRCVLEDLCEFPTLEKDLKEFQKLLR RRHTVDDCPPNQKGKQMYQQLSLKENCVSLRSPAADTREVICCVYVSADSYLSVHTHPSL EAHELLRIVSLKLDRAEEEMVLAVMSNTGERRLLQPSDCVYSESLTPQGKLVACRRDVTE ILPPLSDSTELSRRPVRLLGINTWDVAAALTHLDWTLFKSIHEQELAYYTLSHPPGAGHT AALSVLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIAAHCKAQRNLNSAFAIIMGL NTAAVSRLNQTWEKCPGKFKKLFSELELITDPSLNHKAYREAFKKMKPPKIPFMPLLLKD ITFIHEGNKTFHDNLVNFEKLLNPQHMIADAVRMIRHCQSDQPGNEVIGVDSAEVRGSVQ YLHIIDNQQTLFELSHKLEPRA >Tetraodon nigroviridis_RAPGEF5(ENSTNIP_2394) MCILHDKEDLSRLEMVQRLAKDGCRFLQNHSKGPERPSEQSDEAVLVCLRERGHSVLVLQ RMSSEQPTPSASSRAEREEARDRRYVVVSGTPEKILEHLLNELTLEEDQPKEAETLLDDF LLTYPVFMSTSDLCQALLDSTYCTKRCRGKEDGREALERKRKVLYLVSQWMELCNDFLRD DERIKHFMKTLCSYVLDDLFEHPSLEKDVGELQKLYMLHRRHTTDEYSPQRKSKALFHQL SLRDNGLQSRGVLRESKEALCHVYVTINSFLSVRVHAGVMAQELLQAVAERMDVPQGELL LVAVTYPGGRLLLQPQDRILSDCLRPIGRLHVCRKDLGEILNPFTDNSELQQTAARMLTL NTWDVALALTNLDWAIFHSVHEQELVYFTFGRHSSSSSRTVALELLLQRCNEVQLWVMTE VLLCPLLCKRVQLIKKFIKIAAHCKAQRNLNCFFAIILGLNTAAVSRLSQTWEKIPGKFK KLFSELEAITDPSLNHKAYRESFKKMKAPKIPFLPLLLKDITFIHEGNKTFHDNLVNFEK LHMIADAMRFLRQCQRDHMGNDISQKSSSEARAYIDYLHVIDNQQTLFELSHRLEPRA >Gasterosteus aculeatus_RAPGEF5a(ENSGACP_10631) TSASRLPHSSSADSSSDSTSRAEPVTMPTFDVPYFRYIDDEGTEGDEGWSSSRSMSSIEE DSSTDSVVSDRYMVVSGTPEKILEYLLDDLTLDDDQGTTPTKESDILVDDFLLTYPVFMS TGDLCQALLGQYPCKRYRGKEDRKEALERKRKVLHLVSQWMSLCRGFLREDEHVKLFTKT LYRYVLDDLYEHPFLEKDVRELQKLYQLHRRQAVDEYSPQRKGKALFHQLSLKENSLQSR GTQGETKAALCHVYVTMDSFLSMRAHAGMVAEELLQAVAERMEVPLEKLVLLAVTYNGGR HLLQPQDRVFSDSLRPVGRLHVCRKDLGEVLNPFTDNSELQQRTARMLSINTWDVAVALT DFDWTIFESIHEQELVYFTFSRHSSSSHTVALELLLQRCNEVQLWVMTEVLLCSALCKRV QLIKKFIKIAAHCKAQRNLNCFFAIIMGLNTAAVSRLGQTWEKIPGKFKRLFAELETITD PSLNHKAYRDSFKKMKAPKIPFPPLLLKDITFIHEGNKTFHDNMVNFEKLHMIADTLRLI RQCQKDHMGNGITQKSSSEVRAYIDYLHIIDNQQTLFELSHGLEPRA >Gasterosteus aculeatus_RASGEF5b(ENSGACP_8098) RRSYVGVELVQWLCEQCVYVRCRTTGVRVWQVLLELGVLLSVDQRVMFSDSNSYYQFSFE ECDSASCDFRSNEGEWPEAVRLLLQLAPYIQFRSGGGANSPHPRSEEDSEGNRDICSEML QIQQVQNELAAALARKTRKALSEQDSESTDTSQQEPQTPSEESSPGTGTVCGREELTGRL GLEAVQRLAKDGCRLLQNHNYRVPDRTQADNEAVGRVCLKERGRDVLVLRRVTSSVTSPS DRPSPTSSGGGSREEDCDKRYVVVSGTPLKILEHLLSDLRLDDQRGAPECRESETLLDDF LLTYLVFMSTNDLCQALLGQYPSDRCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEE EHVRSFMKTLYRCVLEDLYEFPTLEKDLKEFQKLLRRRHTVDDCPPNQKSKQMYQQLSLK ENCLQLRSPPSETKEVICCVHVSADSYLSVHTHHSLEGHELLRIVGQKMDRAEEDMVLAV ASHTGERRVLQPSDCVYSESMTPQGKLVACRRDLTEILPPLTDSAELSRRPVRLLGINTC DVAAALTHLDWSLFKSIHEQELAYYTLSRVPGTGHTAALSVLLQRCNEVQQWVMSEVLMC TSLNKRVQLLKKFIKIAAHCKAQRNLNSAFAIIMGLNTAAVSRLNQTWEKCPGKFKKLFS ELELITDPSLNHKAYREAFKKMKPPKIPFMPLLLKDITFIHEGNKTFHDNLVNFEKLHMI AETVRMIRHCQSDQPGNEVIGVDSAEVRASVHYLHIIDNQQTLFELSHKLEPRA >Oryzias latipes_RAPGEF5a(ENSORLP_8886) LTMPTFDVPYFRYIDDEGAEGEEEWSCSRSMSSIEEDSSADSAVSDRYVVVSGTPEKILE HLLSDMTLDDDCGTTQGKESDKLLDDFLLTYPVFMSTSDLCQALLGQYPHKRHRGMEEPK EALERKQKVLHLVSHWMSRCKDFLREDQHVKLFLKTLYRYVLNDLYEHPTLEKEMGELQK LYQLHRRHTGDEDSPHRKSKALFHQLSWKENVPQSRGSQRETKEVLCHVYVTMDSYLSMR VHSEVVVQELLQAVAERMGVSQGELLLVAITCTGGRLLLQPQERVFSASFRSVERLHVCR KDLSEVQNPFVDNSEIQQRTARVLSLNTWDVAVALTDLDWTIFDSMHEQEVIYFTFNRHV CSTYTMALELLLQRCNEVQLWVMTEVLLCPTLCKRVQLIKKFIKIASHCKAQRNLNCFFA IFMGLNAAAVSRLSHTWEKVPGKFKKLFSELEAITDPSLNHKAYRESLKKMKVPKIPFLP LLLKVDITFIHEGNRTFHNNMVNFEKLHMIADMVRLIRQCQKDRMGNGITQKSSSEVRAY IDCLHVIDNQQTLFELSHRLEPRA >Oryzias latipes_RAPGEF5b(ENSORLP_4879) TSMLATLAEAEEDEDEADSEDEDGTNSDTFDVPHLRYIDDDSKEEEKEGSWVDTDCWNSS SYRYVVVSGTPLKILEHLLSDLRLDDQRGAQENRESEMLLDDFLLTYLVFMSTHDLCQAL LVTYGGARCRGQEEGKDALFRKRKVLQLVSHWSRLYKDFLKEEEHVRSFMKTLYRCVLED LYEFPSLEKDLKEFQKLLRRRHTVDDCPPNQKSKQMHQQLSLKENYLHLRTPQTEHKEVM CCVYVSADSYLSVHTHPSLEAHELLRIVGMKMDRAEEDMVLAVVSHTGERRVLQPSDCVY SESLTPNGKLVACRRDLNEVLPPLADSAELNKRPVRLLGINTWDVATALTHLDWTLFKSI HEQELVYYTLSRPPGSGHTAALSLLLQRCNEVQQWVMSEVLMCVSLNKRVQLLKKFIKIA AHCKAQRNLNSAFAIIMGLNTAAVSRLNQTWEKCPGKFKKLFSELELITDPSLNHKAYRE AFKRMKPPKIPFMPLLLKDITFIHEGNKTFHDNLVNFEKLHMIADTVRNIRHCQSDQAGN EVIGVDSADVRASVHCLHIIDNQQTLFKLSHKLEPRA >Homo sapiens_RAPGEF6(ENSP_296859) MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLL WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKG SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRKKRWRSLGSLSQG STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSL QWEPAYGTLTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPI RKKGQTKDPALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTL IPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEH ASGIGDHSQHGPGWTLLKPSLIKCLAVSSSVSNEEISQEHIIIEAADSGRGSWTSCSSSS HDNFQSLPNPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKS WTSSSSLSDTYEPNYGTVKQRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCV TSPKKDDRYREPPPTPPGYLGISLADLKEGPHTHLKPPDYSVAVQRSKMMHNSLSRLPPA SLSSNLVACVPSKIVTQPQRHNLQPFHPKLGDVTDADSEADENEQVSAV >Pan troglodytes_RAPGEF6(ENSPTRP_29440) MNSPVDPGARQALRKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG NQVLFCSETIARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN AKDNEDSILQREIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTENPH PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEI DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV VEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVR TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGTKLLEWFKIDSLRDKVTRIVLL WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES PLQFSLNGGSEKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKAVEILRN NTHLALTVKTNIFVFKELLFRTEQEKSGVPHIPKIAGKKSNRHSIQHVPGDIEQTSQEKG SKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVFHA VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC SDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKTGNTHL KRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA SVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM TFLHEGNDSKVDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLD VQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGT LTKNLSEKRSAKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKD PALNTSLPQKVLGTTEEISGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDN LSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALEKTEHASGIGDHS QHGPGWTLLKPSLIKCLAVSSSVSNEEISHEHIIIEAADSGRGSWTSCSSSSHDNFQSLP NPKSWDFLNSYRHTHLDDPIAEVEPTDSEPYSCSKSCSRTCGQCKGSLERKSWTSSSSLS DTYEPNYGTVKRRVLESTPAESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDR YREPPPTPPGYLGISLADLKEGPHPHLKPPDYSVAVQRSKMMHNSLSRLPPASLSSNLMT CVPSKIVTQPQRHNLQPFHPKLADVTDADSEADENEQVSAV >Macaca mulatta_RAPGEF6(ENSMMUP_8111) MAPTLFQKLFSKKTGLGAPGRDARDPDCGFSWPLPEFDPSQIRLIVYQDCERRGRNVLFD SSVKRKNEDISVSDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSGNQVLFCSETI ARCWYILLSGSVLVKGSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVENAKDNEDSILQ REIPARQSRRRFRKINYKGERQTITDDVEVNSYLSLPADLTKMHLTDNPHPQVTHVSSSQ SGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDDEEEDEEIDRTDPLQGRD LVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILE DGQELDSWYVILNGTVEISHPDGKVENLFMGNSFGITPTLDKQYMHGIVRTKVDDCQFVC IAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKATPERLIMHLIE EHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIVLLWVNNHFNDFE GDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLQFSLNGGS EKGFGIFVEGVEPGSKAADSGLKRGDQIMEVNGQNFENITFMKALEILRNNTHLALTVKT NIFVFKELLFRTEQEKSGVPHIPKIAEKKSNRHSIQHVPGDIEQTSQEKGSKKVKANTVS GGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSP DLLQPTTSMLDFSNPSDIPDQVIRVFKVDQQSCYIIISKDTTAKEVVCHAVHEFGLTGAS DTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELVK ESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLNSKAGNTHLKRFEDIVNQE TFWVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWE KLPSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSE VDGLVNFEKLRMISKEIRQVVRMTSANMDPAMMFRQRSLSQGSTNSNMLDVQGGAHKKRA RRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQMMSLQWEPAYGTLTKNLNEKRS AKSSEMSPVPMRSAGQTTKAHLHQPHRVSQVLQVPAVNLHPIRKKGQTKDPALNTSLPQK VLGTTEEVSGKKHTEDTISVASSLHSSPPASPQGSPHKGYTLIPSAKSDNLSDSSHSEIS SRSSIVSNCSIDSMSAALQDERCSSQALPVPEPTGALEKTEHPSGIGDHSQHGPGWTLLK PSLIKCLAVSSSVSSEEISHEHVIIEAADSGRGSWTSCSSSSHDNFQSLPNPKSWDFLNS YRHTHLDDPIAEVEPTDCEPYSCPKSCSRTCGQCKGSLERKSWASSSSLSDTYEPNYGTV KRRVLESTPTESSEGLDPKDATDPVYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPG YLGISLADLKEGSHPHLKPPDYSVAVQRSKMMHNSLSRLPRASLSSNLMACVPSKIVTQP QRHNLQPFHPKLADVTDADSEADENEQVSAV >Mus musculus_RAPGEF6(ENSMUSP_98766) MNSPVDPGARQALRKKPPERTPEDLNIIYSYLHGMEILSNLREHQLRLMSTRARYERYSG NQMLFCSETIARCWYILLSGSVLVKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN SKDNEDSILQREIPARQSRRRFRKINYKGERQTIIDGVDINNYLSLPADLTKMHLTDNPH PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEEEEI DRTDPLQGRDLVRECLEKEPADKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMVFEV VEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMHGAVR TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDNLRDKVTRIVLL WVNNHFNDFEGDPAMTQFLEEFERNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES PLHFCLTGGSEKGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENITLAKALEILRN NTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDMEQAPQEKG NKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQA VQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC SDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTHL KQFEDIVNQETFWVASEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA PVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM TFLHEGNDSKVDGLVNFEKLRMIAKEIRHIIRMTSANMDPAMMFRQRKKRWRSLGSLSQG STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDIDTDEEKFQMMSL QWEPAYGTLTKNLTEKRSAKSSEMSPVPLRSVGQTAKVHLHQPHRVSQVLQVPAVNLHPI RKKGQAKDHVLSTSLPQKGLGPTEEVSVKKHTEDTISVASSLHSSPPASPQNSPRKGYTL TPSSKCDNLSDSSHSEISSRSSIVSNGSVDSMSAAGQDERCSSHSLAVPEPTGALEKTDH PSGISDHSQLAHGWMLSKPCLIKGVAVSSSLSSEEMSHEHVVLEAADSGRGSWTSCSSSS HDNFQSLQNQKSWDFLNSYRHMHLDDPIAEVEPTDCEPCACPKGCSRTCGQCKGSLETNQ LRQSWASSSSLSDTCEPNYGTVKRRVLESAPAEAPDGLEPRDTTDPVYKTVTSSTDKGLI VYCVTSPKKGDRYREPPPTPPGYLGISLADLKEGPHPHLKPPDYSVAVQRSKMMLNSLSR LPPAPPSSHTSAWVPSKIGSQPQRHSHPKLADVADADSEADENEQVSAV >Rattus norvegicus_RAPGEF6(ENSRNOP_13481) MNSPVDPGARQALRKKPPERTPEDLNIIYSYLHGMEILSNLREHQLRLMSTRARYERYNG NQMLFCSETIARCWYILLSGSVLVKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN SKDNEDSILQREIPARQSRRRFRKINYKGERQTIIDGVDVNNYLSLPADLTKMHLTDNPH PQVTHVTSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEEEEI DRTDPLQGRDLVRECLEKEPADKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV VEQAGAVILEDGQELDSWYVILNGTVEISHPDGKIENLFMGNSFGIVPTLDKQHMRGVVR TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDSLRDKVTRIVLL WVNNHFNDFEGDPAMTRFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRES PLHFSLTGGSEKGFGVFVEVVEPGTKAADAGLKRGDQIMEVNGQNFENITFAKALEILRN NTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDIEQVPQEKG NKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQA VQEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC SDEDAQELLKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTHL KQFEDIVNQETFWVATEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA PVARLRGTWEKLPSKYEKHLQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM TFLHEGNDSKVDGLVNFEKLRMIAKEIRHIIRMTSANMDPAMMFRQRKKRWRSLGSLSQG STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDIDTEEEKFQMMSL QWEPAYGTLTKSLTEKKSARSSEMSPVPLRSAGHTAKVHLHQPHRVSQVLQVPAVNLHPI RKKGQTRDHVLSTNLPQKGLGPTEEVSGKKHTEDTISVASSLHSSPPASPQSSPRKGCTL TPSSKCDNLSDSSHSEISSRSSIVSNGSVDSMSAAGQDERCSAHSLAVPEPTGAWEKTDH PSGISDHSQLAHGWMLSKPSLIKGVAVSSSLSSEEMSQEHVVLEAADSGRGSWTSCSSSS HDNFQSLQNQKSWDFLNSYRHTHLGDPIAEVEPPDCEPCACPKGCSRTCSQCKGSLETNQ LRQSWASSSSLSDTWEPNYGTVKRRVLESTPAEAPDGLEPRDTSDPVYKTVTSSTDKGLI VYCVTSPKKGDRHREPPPTPPGYLGISLADLKEGSHPHLKPPDYSVAVQRSKMMLLNSLS RLPPAPPSSHTSAWVPSKIGSQPQRHSLQPSHPKLADVADADSEADENEQVSAV >Bos taurus_RAPGEF6(ENSBTAP_0910) MGEKPDGNKQLLLRKIAAQARITPVLQDLNTIYSYLHGMEILSNLREHQLRLMSARARYE RYSGNQVLFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMI VVENSKDNEDNILQREIPARQSRRRFRKINCKGERQTITDDVDINSYLSLPADLTKMHIA DNPHPQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEE DEDIDRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVM IFEVVEQAGAVILEDGQELDSWYVILNGTVEISHPDGKVDNLFMGNSFGITPTLDKQYMH GVVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIV IKGTPERLIMHLIEEHSIVDPTYIEDFLLTYRTFLASPLDVGTKLLEWFKIDSLRDKVTR IVLLWVNNHFNDFEGDPAMTQFLEEFEKNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKA SRESPLHFSLSGGSEKGFGIFVESVEPSSKAADAGLKRGDQVMEVNGQNFENITFVKALE ILRNNTHLALTVKTNIFVFKELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDLEQTS QEKGNKKIKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSL AIMPIPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEV VCQAIHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMET ETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLESKTG NTHLKEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISG LNLASVARLRGTWEKLPSKYDKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVV KKDMTFLHEGNDSKVDGLVNFEKLRMIAKEIRQVVRMTSANMDPAMMFRQRKKRWRSLGS LSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQ MMSLQWEPAYGTLTKNLNEKKSMKSSEMSPVPLRSAGQTTKAHLHQPHRGSQVLQVPAVN LHPIRKKGQGKDPATLSTGLPQKILGTAEEVSGGKKHTEDTVSVASSLHSSPPVSPQGSP RKGYTLIPSAKSDNLSDSSHSEISSRSSIVSNCSVDSMSTALQDERCSSQAVAVPESTGA LEKTEHSSGIGDHSQLGPGWTLSKPSLINKSLAVSSSVSNEEISHEHIIIETADSGRGSW TSCSSSSHDNFQSLPNPKGWEFLNSYRPTHLDGPIAEVEPTDCEHYSCPKGCSRTCGQCK GSLETNQMRQSWASSSSLSDTYEPNYGTVKRRVLENTPAESSEGLDHKEGIDPVYKTVTS STEKGLIVYCVTSPKKEDRYREPPPTPPGYMGISLADLKEGPHLHLKPPEYSVAVQRSKM MHNSLSRLPPASLSSSPVACVPSKIVIQPQRHKLDVTDGDSEADENEQVSAV >Loxodonta Africana_RAPGEF6(ENSLAFP_0396) MNSPVDPGARQALKKKPPERTPEDLNTIYSYLHGMEILSNLREHQLRLMSARARYERYSG NQILFCSETIARCWYILLSGSVLMKDSMVLPPCSFGKQFGGKRGCDCLVLEPSEMIVVEN SKGNEESILQREIPARQSRRRFRKINYKGERQTITDDVEINSYLSLPADLTKMHLTDNPH PQVTHVSSSQSGCSIASDSGSSSLSDIYQATESEVGDVDLTRLPEGPVDSEDEEEEDEEI DRTDPLQGRDLVRECLEKEPADKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEV VEQAGAIILEDGEELDSWYVILNGTVEISHPDGKIENLFMGNSFGITPTLDKQYMHGVVR TKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKGHIVIKAT PERLIMHLIEEHSIVDPTYIEDFLLTYRTFLESPLDVGIKLLEWFKIDSLRDKVTRIILL WVNNHFNDFEGDPAMTRFLEEFEKNLEDTRMNGHLRLLNIACAAKAKWRQVVLQKVSRES PLHFGLNGGSEKGFGIFVEGVEPGSKAADAGLKRGDQIMEVNGQNFENITFVKALEILRN NTHLALTVKTNIFVFKELLSRTEQEKTGVPHIPRIAEKKSNRHSIQDVPGDIEQTSQEKG NKKVKANTVSGGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGTRHCRHSLAIMP IPGTLSSSSPDLLQPTTSMLDFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVCHA VHEFGLTGASDTYSLCEVSVTPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLC SDEDAQELVKESQLSMLQLSTIEMATQLSMRDFDLFRNIEPTEYIVDLFKLDSKTGNTHL KEFEDIVNQETFWVASEILTESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLA PVARLRGTWEKLPNKYEKHFQDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDM TFLHEGNDSKVDGLVNFEKLRMIAKEIRQVVRMTSANMDPAMMFRQRKKRWRSLGSLSQG STNSNMLDVQGGAHKKRARRSSLLNAKKLYEDAQMARKVKQYLSSLDVETDEEKFQIMSL QCEPAYGTLTKNLGEKRSAKSSEMSPAPMRSAGQTAKAHLHQSHRVSQVLQVPAVNLHPI RKKGQTKDSVTLSTSLPQKVSGTTEEISGKKHTEDTISVASSLHSTPPASPQGSPRKGYT LIPPAKSDNLSDSSHSEISSRSSIVSNCSVDSMSAALQDERCSSQALAVPESTGALGKTE PPSGIGDHSQLGPGWTLSKPSLIKGLAVSSSMSSEEISHEHIIIEAADSGRGSWTSCSSS SHDNFQNLPNPKSWDFLNSYRHTHLDGPIAEVEPTDCDPYSCPVACSRTCGQCRGSLETN QLRQSWASSSSLSDTYEPNYGTVKRRVSENTPAEPSEGLDAKDGTDPMYKTVTSSTEKGL IVYCVTSPKKDDRYREPPPTPPGYMGISLADLKEGPHPHLKPPDYSVAVQRSKMMHNSLP RLPPAPLSSSPMACVPSKIVTQPQRHNLQLCHPKLADVTDADSEADEDEQVSAV >Monodelphis domestica_RAPGEF6(ENSMODP_32034) ATESEIGDVDLTGLPEAPVDSEDEEEEDEDIDRTADPLLGRDLVRECLEKEPADKTDDDI EQLLEIMHQLPAFANMTMSVRRELCSVMIFEVVDQAGAVILADGQELDSWYVILNGTVEI SYPDGKNESLCMGNSFGIIPTLDKQYMNGVVRTKVDDCQFVCIAQQDYWRILNHVEKNTH KVEEEGEIVMVQEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSVVDPTYIEDFLLTYR TFLESPLEVGNKLLEWFKLDSLRDKVTRVVLLWVNNHFNDFEGDPAMTGFLEEFEKNLED TKMKGHLRLLNIACAAKAKWRQILLQKTSRESPLFFSLSGGSEGFGIFVEGVEPGSKAAE AGLKRGDQIMEVNGQNFENITLGKALEILKNNTHLSLTIKTNIFVFKELISRTKQEKNGV PHIPKIAEKKSNRYSIPDMPGDMEQIFPQEKGNKKIKANTVSGGRNKIRKILDKTRFSIL PPKLFSDGSVSQSQDDSVLGTRQCRHSLAIMPIPGTLSSSSPDLLQPTTSMLDFSNPTDI PDQVIRVFKADQQSCYIIISKDTTAKEVVSHAVHEFSLTGAPETYSLCEVSVSPEGVIKQ RRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLRESQITLLQLSTIEVATQL SMRDFELFRNIEPTEYIDDLFKLNSKTGNTHLKEFEDIINQETFWVASEILTESNQLKRM KIIKHFIKIALHCRECKNFNSMFAVISGLNLAPVARLRGTWEKLPSKYEKHLRDLQDLFD PSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSKVDGLVNFEKLRMIAKEIR QVVRMTSANMDPAVMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKK LYEDAQMARKVKQYLANLNVETDEEKFQIMSLQWEPAYSTLNKNLSERRSTKSSEMSPVP LRSVGQITKAHLHQPNRMSQVLQVPAVNLYPIRKKGPTKDHIAFGPSASQKIVGMSEEVS GKKPAEDTLSMASSLHSSPPASPQGSPRKGYAHIPSAKSENFSDSSHSEISSRSSIVSNC SVDSMSAALQEDRCLPQSLSGVDSVGTAEKKENPPVTTDHIQHVAGWTLPKPSLVKGLAV PSSVSTEEISHDHITIEAVDSGRGSWTSCSSSSHDNFQNIQNQKSWDLLNSYRHTHLDVP IAEVEPTNCEPYLYAEGYTLTNCQPKDGTEWVQSRQSWASSSSLSDTYETNYGTVKRRVV EDSTVEPDETLDSHASTDTTYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPPGYMGIS LADIKEGPPHHPHLKPPDYSVAVQRSKMVHSNLSRLSSASLGSEPMACISSKIPSQPQWH ILQPSHPKLAGVTDADSEADENEQVSAV >Gallus gallus_RAPGEF6(ENSGALP_39237) DLNTIYSFLHGLDILSHFREHQLRIMSSSARYERYKGNQVLFCSETIARCWYILLSGSVL MKDSMFLPPCSFGKQSGGKRGCECIILEPSEMIVVENSKDNEESILQREVPLRQSRRRFR KINQRGERQTITDNVDASSYLSLPADLTKMHLTDNPHPQVTHVPSSQSGCSIASDSGSSS LSDIYQATESEMGDVDLTGLPEAPVDSEDEEEEEDEDIDRTSDPLLGRDVVRECLEKEPA DKTDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVI LNGTVEISYPDGKSESLCMGNSFGITPSLDKQYMNGVVRTKVDDCQFVCIAQQDYWRILN HVEKNTHKVEEEGEIVMVKEHRELDRSGTRKGHIVIKATPERLIMHLIEEHSIVDPTYIE DFLLTYRTFLTSPLEVGNKLLEWFTVDSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEE FEKNLENTKMKGHLRLLNIACAAKAKWRQITLQKPSRDSPLFFSLLGGSDKGFGIFVETV EIGSKAAEAGLKRGDQIMEVNGQNFENITFAKALEILRNNTHLSITVKTNIFVFKELLCR IGQEKNGIPHIPKIAEKKNNRYSIPDMPGDVEQMFPREKGNKKLKANTVSGGRNRIRKIL DKTRFSILPPKLFSDGGVSQSQDDSIVGTRQCRHSLAIMPIPGTLSSSSPDLLQPTTSIL DFSNPSDIPDQVIRVFKADQQSCYIIISKDTTAKEVVSHAVNEFNLTGAPETYSLCEVSV SPEGVIKQRRLPDQFSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLKESQISLLQLS TIEVATQLSMRDFELFRNIEPTEYIDDLYKLDSKTGNAHLKQFEDVINQETFWVAMEILA EPNQLKRMKIIKHFIKIALHCRECKNFNSMFAVISGLNLAPVARLRGTWEKLPGKYEKHL RDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSKVDGLVNFEKL RMIAKEIRQVVRMTSANMDPAVMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARR SSLLNAKKLYEDAQMARKVKQYLSNLNVETDEEKIQILSLQCEPAYSTLTKNLSERRGAK SSEMSPVPLRSIGQTTKAHQQNRMSQVLQVPSVNLYPSRKKGLTKDHVTFSTGSPQKSLS LSEEVSSKKQTDDTMSMASSLHSSPPASPQGSPRKGYALIPSTKSDNFSDSSHSEISSRS SIVSNCSVDSMSAALQDERSLSQSLLVVDTAGMERKEHSQAEYGQPCPGWSVTRPALIRG MAFTSSMSNEEISHEHITVEAADSGRGSWTSCSSSSHDNFQNIPNQKSWDLLNSYRHTQL DGPIAEVDPTNCYSEEAYLYSEAFAKNNRQSKASTELDQSRQSWASSSSLSDTYETNYGT IKRRGLENSTSEQAEVLDSKPGTDTAYKTVTSSTEKGLIVYCVTSPKKDDRYREPPPTPP GYMGISLADIKEGSPHHPHLKPPDYSVAVQRSKMLHSDLSRLSSAPLGSDPVACIASKMP QWHSRQPSGPQLADMPGADSEEDEDEQVSAV >Xenopus tropicalis_RAPGEF6(ENSXETP_18397) DLKTVYSYMHRMDILSHLREHQLRLMSATARYERYSANQVLFCSESLARCWYILLSGSVL VKNSMFLPPCSFGKQSGGKRGCDCIVLEPSEMIVVENTGENNDGILHRETSIRQSRRRYR KINQHGERQTITDNGDAASYVLLPTDLSKIHLTDSPHPHVTHVPSSQSGCSIASDSGSSS LSDIYQATESEMGDVDLTGLPEAAVDSEDEEEDEDIERASDTMLTRDIVRECLEKEPTDR TDDDIEQLLEFMHQLPAFVNMTMSVRRKLCSVMIFEVVEQAGAIIIEDGQELDSWYVILN GIVEISHSDGRMENLCMGNSFGINPSLETQYMDGVVKTKADDCQFVCIAQQDYFRILNHV EKNTHKVKEKGEIVMVNEHRELDRSGTRKGHIVIQGTPERLILHLIEEHSVVDPTYIEDF LLTYRTFLSSPLEVGDKLLEWFKDDSRRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFE RNLENAKMKGHLRLLNIACAAKAKLRQVTLLKPSRESPFYFNVVGGSDKGFGMFIESVEP GSKATEAGLKRGDQIMEVNGQNFETIVYAKALEILKNNTHLSITVKTNIFVFKELLNRIG QEKKNGVPHIPKIAEKKNNRYSIPDLPNDVEQMFPRDRASKKMKANTVSGGRNRIRKILD KTRFSILPPKPFSDGHVIQSQDDSIVGTRQCRHSVAIMPIPGTLSSSSPDLLQATTNILD FSNPTDIPDQVIRIFKADQQCCYIIIGKDTTAKEVVIQALHEFSLTGSTDTYSLCEVSVS PEGVIKQRRLPDQLSKLADRIQLNGRYYLKNNMETETLCSDEDAQELLRESLISLLQLST IEVATQLSMRDFELFRNIEPTEYIDDLFKIDSKTSAAHLKQFEEVINQETFWVATEILRE PNHLKRMKIVKHFIKTALHCRECRNFNSMFAIIRSGLNLAPVARLRGTWEKLPSKYEKLL RDLQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDITFLHEGNDSKVDGLVNFEKL RMIAKEIRHVIRMTSANMDPAVMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGGHKKRARR SSFLNAKKLYEDAQMSRKVKQYISNLSVEIDEEKIQLMSLQCEPAYSTLAKNLSERRSAK SDLSPAPLRPSGQTTKAHIHQQNRMSQVLQVPTVNLYPMRKKAPTKEHLPCTSGSSQKIS GLTDEVTVKAQLEDSVSLVSSLHSSPAASPQGSPHKGYAHNPSAKSDNFSDSSNSEISSR SSLVSNCSVDSMSLTLQDEKCVPHSHAESMGLSERKDVHPSSEYNQPCSSWLHARHPAVR NFIACASSEDIAHDHISVEPVDSGRGSWTSCSSSSHDNFQTLQKGLDRLSTYRQSHIDSP IAETESANCSTDETCSEDCTKGKRHSNNSLELNESRQSWASSSSMSDTYETNYGTIKRRV LDTEEKTEALGQQLDVFYKTVTSTTEKGLIVYCVTSSQKDSRYREPPPTPPGYQGISLAD IKEGQPHQAHLKPPDYSVAIQRSKMIHKDLSRLSSA >Takifugu rubripes_RAPGEF6(ENSTRUP_14901) SSSISSLFVSSILQSPPQRTHQDLHTIYCHLYHMDVLSHLREHQLRSMCTSARYERHGAN HILFYPDSIATCWYILLSGSVFVKEHMYLARCCFGRQLGGRRGCECITLEPSEMIVVDNG SEGDDSFLQREGSQRRSRRRFRRINPRGERELITDGQEPSGYTKLPGDLNKMHLTDHAHQ QVMHVPPSQSGCSIASDSGSSSLSDIYQATESELGDVDLSGLPEAVVDSEEDEEEDEDLE RASDTLLGRDLVRECLEKDPVDRNDDDIEQLLEFMHQLPAFANMTMSVRRELCSVMVFEV VEQAGTVILHNKQELDLWYVILNGAVEFSYPDGRMETLCMGNSFGISPSLDKQYMNGEVR TKGDDCQFVCIAQEDYWRILNHVEKNTHKVEEEGEIVMVKEHRELDRSGTRKGHIVIKGT PDRLIMHLVEEPSVVDPTYIEDFLLTHRTFLSNPMDVGKKLFEWFQVDTLRDTVTRIVLL WVNNHFNDFEGNPAMTRFLEDFEKLLETTKMKGHLRLLNIACAAKAKLRQITLQKASRDS PLHFSVQGGSERGFGVFVDSVEEGSKAAETGLKRGDQIMEVNGQNFDNISITKAVDILRN NTHLSLTIKTNIFVFKELLSRVMHEKKNGGPHIPKIQEKKGNRFSIPDLPGDMEFPSDHK SNRKLKANTVSGGRNKIRKMLEKTRFSILPPKPFSDGGMVQSQDDSIVGTKQCRHSVAIM PIPGNLSSSSPDLLQPATSVLDFSNPADIPDQVIRVFKADQQSCYIIISKDTTAKDVVAH TVNEFGLVAAPETYSLCEVSVSPEGVIKQRRLPDQLSKLADRIQLNGRYYLKNNMETETL CSDEDAQDLLRESQISLLQLSTMEVAAQLSMRDFDLFRNIESTEYVDDLFKLDTSIGSGN LKQFEEVINKETFWVASEILKEPNALKRMKTIKHFIKIALHCRECKNFNSMFAIISGLNL APVARLRSSWEKLPSKYEKLFGDLQDVFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKD LTFLHEGNDSTVDGLVNFEKLRMIAKEIRHVVRLTSANMDPALMFRQRKKRWKSLGSLSQ GSTNSNMLDVQGGAHKKRVRRSSLLNAKKLYEDAQMARKVKQYLSNLTVETDEEKHQVMS LLCEPSYSTLSKYLSERRSTKSDMSPVSLRSALPSAKTQNRVSQVLQVQVPLNHLRKKST AKDTGTPNSNSPQVVKKPPVSSSEEWSSKRPSDDAVSLISSLHSSPTVSPHGSPRKGYAF LPASKADNLSDSSHSEISSRSSICSVDSMPAPGPDDRCSSGNRTAAGAAMPSPAAVADGT AATYTHSNADYSQPSTSNSSPLARGYVPRGSTFTSSASTEELTPDHASLDSVADSGRSSW TSCSSNSHDSFQSLPPSSCRPWDHGIHGHPLAFAHLGGFKHTQLAGPIAEIEAATQAWMN EDAAAKQHSRNSSSDLSNQSRQSWASSSSLSDTYEGNYGTIKRRNTAEHPSSPTSEEGGQ STDHVYKTVTSSTEKGLIVYCVTSPAKDERYRAPPPTPPGYQGLALGDLGLADAVVSGPG GLGPRPPHLRPPDYSVALQRSKLLQSPGASGGLAEARRLAANRLLQHQEDRSSGSTQGHS RPASICLPAQDLADSDDGTHEQVSAV >Tetraodon nigroviridis_RAPGEF6(ENSTNIP_19179) LGQSESVQLPGDLNKMHLTDHAHQQVMHVPPSQSGCSIASDSGSSSLSDIYQATESELGD VDLSGLPEAAVDSEEDEEEDEDLERASDTLLGRDLVRECLEKDPVDRNDDDIEQLLEFMH QLPAFANMTMSVRRELCSVMVFEVVEQAGTIILHNKQELDLWYVILNGAVEISYPDSRME TLCMGNSFGISPSLDKQYMHGEVRTKGDDCQFVCIAQEDYWRILNHVEKNTHKVEEEGEI VMVKEHRELDRSGTRKGHIVIKGTPERLIMHLVEEPSVVDPTYIEDFLLTYRTFLSNPME VGKKLLEWFQVDTLRDTVTRIVLLWVNNHFNDFEGNPAMTRFLEEFEKLLETTKMKGHLR LLNIACAAKAKLRQITLQKASRESPLYFSVQGGSERGFGIFVDSVEEGSKAAETGLKRGD QIMEVNGQNFENIPITKAVDILRNNTHLSLTIKTNIFVFKELLSRVLHEKKNGGPHIPKI QEKKGNRFSIPDLPGDMECPLTQEPRKCSNTVSGVSFLSPFNSNPPLTPIPALLCSDGGM VQSQDDSIVGTKQCRHSVAIMPIPGNLSSSSPDLLQPATSVLDFSNPADIPDQVIRVFKA DQQSCYIIISKDTTAKDVVAHSVNEFGLIAAPETYSLCEVSVSPEGFIKQRRLPDQLSKL ADRIQLNGRYYLKNNMETETLCSDEDAQDLLRESQISLLQLSTMEVAAQLSMRDFELFRN IESTEYLDDLFKLDTSIGSRNLKQFEEVINQETFWVASEILKEPNTLKRMKTIKHFIKIA LHCRECKNFNSMFAIISGLNLAPVARLRSSWEKLPSKYEKLFGDLQDVFDPSRNMAKYRN VLSSQSMQPPIIPLFPVVKKDLTFLHEGNDSTVDGLVNFEKLRMIAKEIRHIVRLTSANM DPALMFRQRKSLPPSCMSLSQGSTNSNMLDVQGGAHKKRVRRSSLLNAKKLYEDAQMARK VKQYLSNLTVETDEEKFQFMSLQCEPSYSTLSKYLSERRSTKSDMSPVSLRSALPSAKTQ NRVSQVLQVQVPLNPLRKKSNAKDTGPPNSNSPQVVKKPPVSSSEEWNTKRPSDDTVSTV SSLHSSPTVSPQGSPRKGYTFLPAGKADNLSDSSHSEISSRSSICSVDSMPAPGPDERCS GTNRTAAGVATTTPAMVTDSTAHTHFNADYSQPSTSNSSPSARGYVPRGSAVTSSASTEE LTPDHTSLDSVADSGRGSWTSCSSNSHDSFQSLPSSSCRPWDHGIHGHPLAFAHLGGFKH TQLAGPIAEMEAATQAWLKEDGAAKQHSRNSSSDLSNQSRQSWASSSSLSDTYEGNYGTI KRRNASEHPSSPTNEEGGQSTDHVYKTVTSSTEKGLIVYCVTSPSKDERYRAPPPTPPGY QGLALGDLGLADGSASGPGGLGPRPPHLRPPDYSVALQRSKLL >Homo sapiens_RAPGEFL1(ENSP_394530) MLIHPRGLPSSSHRRKINSTYFYILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEGPE GLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQL VETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIR SRLSASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINS HLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDY VFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQD LLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPP VIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNH LQTKAYVRQFQVIDNQNLLFELSYKLEANSQ >Pan troglodytes_RAPGEFL1(ENSPTRP_15539) MEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTL RLHQLVETVELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHS YVTIRSRLSASVQDILGSVTEKLQYSEEPTGREDSLILVAVSSSGEKVLLQPTEDCVFTA LGINSHLFACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHEL EFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALC KQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVIS KMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDME ASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ >Gorilla gorilla_RAPGEFL1(ENSGGOP_4973) GGPSGGQRSLQRRQSVSRLLLPAFLREPPAEPGLEPPPEEGGEPAGVAEEPGSGGPCWLQ LEEVPGPGPLGGGGPLRSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLNRVLERLAG GATRDSAASDILLDDIVLTHSLFLPTEKFLQELHQYFVRAGGMEGPEGLGRKQACLAMLL HFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVETVELKIPEENQ PPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGS VTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLFACTRDSYEAL VPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETAN LELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDN AAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLT FLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVI DNQNLLFELSYKLEANSQ >Mus musculus_RAPGEFL1(ENSMUSP_103103) MKPLEKFLKKQTSQLAGRAVTGGPGGGPGCCGGPGGGGGPGGGGGPAGGLRPLQRRQSVS RLLLPAFLREPPTEPGLEPPVEEEGGEPLGVSEEPGSGGPCWLQLEEVPGPGPIGSGVPL RSPSSYSSDELSPGEPLASPPWAPLGAPERPEHLLNRVLERLAGGTTRDSSASDILLDDI VLTHSLFLPTEKFLQELHQYFVQSRNVEGPEGLGRKQACLALLLHFLDTYQGLLQEEEGA GHIIKELYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRI DSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAERED ALILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEVQVSPGDTEI HRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVA TEVLLCEAPGKRVQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGK FKNLFRKFEGLTDPCRNHKSYREVISKMKPPLIPFVPLILKDLTFLHEGSKTLVDGLVNI EKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVIDNQNHLFELSYKLEAN SQ >Bos taurus_RAPGEFL1(ENSBTAP_20265) MKPLEKFLKKQTSQLAGRTVAGGPGGGPGSCGGPGGGGGPGGGGGPAGGPRPLQRRQSVS RLLLPAFLREPPAEPGLEPPPEEDGGEPTGVAEELGSGGPCWLQLEEVPGPGPLGGGGPL RSPSSYSSDELSPGEPLTPPPWAPLGAPERPEHLLNWVLERLAGGATRDSAASDTLLDDI VLTHSLFLPTEKFLQELHHEFLQAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGA GRIIKDLYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFHRI DSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGRED SLILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSFEALVPLPEEIQVSPGDTEI HRGEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVA TEVLLCEAPGKRAQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGK FKNLFRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNI EKLHSVAEKVRTVRKYRSQPLCLDMEASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEAN SQ >Loxodonta Africana_RAPGEFL1(ENSLAFP_20681) MKPLEKFLKKQTSQLAGRTVTGGPGGGPGSYGGPGGGGGPGGGGGPAGGTAPLQRRQSVS RLLLPAFLREPPAEPGLEPPPEEEGGEPAGVTEEPGSGGPCWLQLEEVSGPGPLGGGGPL RSPSSYSSDELSPGEPLTSPPWAPLGAPERPEHLLIRVLERLTGGATRDSAASDILLDDI VLTHSLFLPTEKFLQELHQYFVRAGGMEGPEGLGRKQACLAMLLHFLDTYQGLLQEEEGA GRIIKDLYLLIMKDESLYQDLREDTLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRI DSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAGRED SLILVAVASSGEKVLLQPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEIQVSPGDTEI HRVEPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVA TEVLLCESPGKRAQLLKKFIKIAAICKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGK FKNLYRKFENLTDPCRNHKSYREVISKMKPPVIPFVPLILKDLTFLHEGSKTLVDGLVNI EKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEAN SQ >Monodelphis domestica_RAPGEFL1(ENSMODP_16388) PTERFLQELYHFVQSDGIEGAEGLGRKQACLAVLLHFLETYQGLLQEEECAGRIIKDLYL LIMKDESLYQDLREETLRLHQLVETVELKIPEESQPPSKQVKPLFRHFRRIDSCLQTRVA FRGSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVSEKLQYSEESGGREDSLILVAVAS SGEKVLLQPSEDCVFTTLGINSHLFACTRDCYEALVPLPEEIQVSPGDTEIHRVEPEDIA NHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEPL GKRAQLLKKFIKIAAICKQNQDLLSFYAVIMGLDNAAVSRLRLTWEKLPGKFKNLFRKFE NLTDPCRNHKSYREVVSKMKPPVIPFVPLILKDLTFLHEGSKTLLDGLVNIEKLHSVAEK VRTIRKYRSRPLCLEMEASPHHLQTKAYVRQFQVIDNQNLLFELSYKLEANSQ >Xenopus tropicalis_RAPGEFL1(ENSXETP_58901) MKPLEKFLKKQSSHLSGPRHLHRRQSVSKILPSFLRDTPGDSSGGERCEEDPSGGPPPSQ DCLELPDGLRSPLSFSSDELSPSEPLTPPPGSGGWTLSPPGPLLAPDTPEALLGRVLEQL LSAPRLNEAAELALDDFILTHTLFMPTEELLLQLQQRLASCLRYTTPAWEGSDPLQRKQA VLSSLLHLLDIYKDALQEEERTFQLIKDFYVLVMRDAPNFPQLEGSVIRLHRLVESAELR LTDGSATQCSKQVKPLFRHFRRIDSCLQPRVAFRGSDEIFCRVYMPDHSYVTIRSRLSAS VSDILTSVSEKLQYSEEQGQREEPLILVAVTSAGDKVLLKPDDGCIFTTLGINSHLFACN REELRSLVPLPEEVQLPPEDSHIHRIEAEDLANQLSAFHWELFSCVHELEFIDYVFHVER GRRETANLELLLQRCSEVQHWVSTQTLLCEGPARRTQLLKKFIKTAAICKQNQDLLSFFA IVMGLDNGAVSRLRVTWEKLPGKCKNLFRKFENLTDPCRNHKSYREMVSRMRPPVIPFIP LILKDLTFLHEGSKTFIDGLVNVEKMHAIAEKVRTVRKYRSNQLRLDTDVSPTHLQNKAY VRQFQVIDNQNLLFELSCKLEPNTQ >Danio rerio_RAPGEFL1(ENSDARP_100483) MPAGMKPLEKFLKKQTNALTRAGGFGEKATGTGASRRRASLSRVVPFFRETSPESGPARE VFSPETEEAPCWPSATADIRSPSLSSDEQSSEASLDTNWTPLPADTPENLALALLDSVAG KRYANCTEILLDDFMLTHPIFLAPDKFQQVLLQQFSSEGKQGEGWPGWDGAERKLAVLTV AFRYLDTYRDLLQEEGDRSNTFPKELYLCAVDELNRFPELVEDVLKLQRWTEILHSPAEE DKESRKKQVRPLFRHFRRIDACLQPREAFRGSDEIFCRVYTPDHSYVTIRSRLSCRVGEI LALVKEKLQYSEDQPTQPANLILVAVTSSGEKAVFRPSDEAVFTTLGVNTHLFACEPAEL ESLIPLPEEIHWTPGDSKLHDMSAEEVANQLVVFDWELFSCVHEVEFVCYVFHGEQARWR PLNLELILQRCSEVQHWVATEILQCQSLPKRIQLLRKFIKIAALCKQQQDLLSFLALVLG LDNPAVSRLRLTWEGLPGKFRKQFQQFESIADPSRNHKSYRDLLASLRAPLIPFTPLLLK DLTFLHESCKTFHGELVNFEKMHKVAEMVRSIRRYRSSQLAMEAEPSPSHLQTKAYVRQL QVIDNQNLLFEMSSKLEPKDM >Tetraodon nigroviridis_RAPGEFL1(ENSTNIP_5787) DGVRRKRAVLSVAFRYLDTYRELLQEEGDRSNSFPKELYLCAVEQLRRYPELVEDVLKLQ RWTEILNCPSDEEKETRKKQVRPLFRHFRRIDACLQPREAFRGSDEIFCRVYTPDHSYVT IRSRLSCRVGEILALVREKLQYSEEQPVLPGNLVLVAVTSAGEKAVFRPSDEAVFTTLGV NTHLFTCEPSELDSLLPLPEEIHWSPGDSKLHDMSAEEVATQLVVFDWELFSCVHEVEFL CYVFHGEQARWRPLNLELVLQRCSEVQHWVATEILQCQSLPKRVQLLRKFIKIAALCKQQ QDLLSFLAVVLGLDNPAVNQLRLTWEGLPGKFKKQFQQFESIADPSRNHKSYRELISSLR PPLIPFTPLLLKDLTFLHESCKTFHGELVNFEKIDVVSRDVRGPTKACFKPAAMDTETSP SHLQTKAYVRQLQVIDNQNLLFEMSCKLEPRDT >Gasterosteus aculeatus_RAPGEFL1(ENSGACP_1453) SAPLFLSQLHETFSLETQGEEGGGGGSEVARKRAVLSVVFRYLDTYRELLQEEGERSNSF PKELYLCAVQELSQYPELVEDVLKLQRWTEILNSPSVAEKESRRKQVRPLFRHFRRIDAC LQPREAFRGSDEIFCRVYTPDHSYVTIRSRLSCRVGEILALVREKLQYSEDQPVLPGNLV LVAVTSAGEKAVFRPSDEAVFTTLGVNTHLFTCEPSELDSLLPLPEEIHWTPGDSKLHDM SAEEVANQLVAFDWELFSCVHEVEFVCYVFHGEQSRWRPLNLELVLQRCSEVQHWVATEI LQCQSLPKRVQLLRKFIKIAALCKQQQDLLSFLAVVLGLDNPAVSRLRLTWEGLPGKFRK QFQQFESVADPSRNHKSYRDLITSLRPPLIPFTPLLLKDLTFLHESCKTFHGELVNFEKM HKVADMVRIIRRYRSSQLAMDTETSPPHLQTKAYVRQLQVIDNQNLLFDMSCKLEPKDT >Ciona intestinalis_(ENSCINP_1063) MYSYLIQTKPDIITEHQSDEEISGLADDDVVTYRNCCFGHELVAWLCGYIKTTNLALISE LSRFHVNGLWQVLLEEGLVYHVRHEQYFEDTRYLYQFHNEVTEYAQTAEELEVTEDKMGW VLAYLNQSSPDTMLRTALRKLPEHRTSEELELIYDEILHMKALTQLSDQVKQQLAAVLQF EFYHKSGETIFHQGDEGRSWYIISKGSVDVVIQGKGVVCTLHEGDDFGSLAIVNDAPRAA TIVTTKPNCQFLRVDKYDFNKIHEEVESKTVRLKEHGKDVLILQKSLKTKEGGTSAYVGS RGQKRYNISAGTAEKIVNHILESLQPWVKPRHEENLEDFLLTFRFFTTTQKLCDLLLQRY NSEVVNGAECSRSLKKRVVYLVVRWSYISTHLFIQDLVVQNFLQVLRENIAEDIQKNLAY LELQIRFSCDQCNSCQYFNSDEVGNVLTVGETIQRYPSPSSHDEQCAIHDNDEVLLKIYD LQSSYTTVKVPICLTCEETVNAACEKINRSPNKMLLFEVQENNDIHAIPKHQMSVATSTK LNSRLYMCIPDERDELASIQLPPPTIQPTTCMETVSSLEIAYHVTQHDWQLMNNIHLPKL LSFIPINNRLFSSLKMYGNMFGFMAVMIGIGNQAISRLHGTWDKLPTKYRKLVDEFETIL DPSRKHRNYRVFVSSTNSARIPYFPLLMKDLTFQHEGNDTFNKNGLVNFEKMHMLSNSIR LVVHGCSRSLDIIQPACSVLSSKTNKVIISPLNNQFFESTKTAEESRNYTREVSVITNQI LLNEMSNKLEP >Ciona savignyi_RAPGEFL1(ENSCSAVP_13142) EESQQISEEELVSALADLKRKSPDAMFRSALRKLPEHRTATELEMIYDEILHINALKELS NEIKKQLTKVIQFEFHQQVGTTLFHQGDEGRSWYVILSGVVDVLIHGKGVVCSLHEGDDF GNLAIVNDAPRAATIVTAQPNCQFLRVEKFDFVKILNEVEAKTDRLKEHGKDVLILEKNS LKSRSGSMADTLTPSNYKYSIARGTVDKILEHILRYIQPWVLTGMEDSMEDFIITYKLFT DSKHLCEYLLKQYRAGDSLKKGVVYFVVRWSHIHTYIFHEDPDIQSFLKELRKQVIQDVL ENEIYEELQEDLECVYKPHGKPGLLNRRSSNNGTSGASQVVLTVGTSVQRYPMSKQNGAE PIHDSDKVLLKIYDWNNTYTTVKLPISATCGEIIAAACEKLSNSPSDFKLVELHENHDTN EIPKRQTSVATAVSLNSRLYLTTTGDHPYLVNKQSASKTIEASHMETVSSLEIAYHLCKH NWNLMNNIHILEFLFKTCGGHKFKWTTSNLNVMARRFNQLAYWPPTEICLCANINKRVQL LRKFIKWDTYLKMYHDMFGFMAVMIGIGNQAVSRLHDTWDKLPSKYRKMVQGFEGILDPS RNHRNYRLFVASTESTRIPYFPLIMKDLTFMQEGNDTFKDDLVNFEKMRMTSKLIRQVVD GCRNPLEVDNLLETTKTAGTTKKYAITCPVITNQVVLNEMSNTVEPKRT >Branchiostoma floridae_(XP_02600702) MVQQWSRIVGDAFIESKTIKAFLEELCLAVSEDCQTWPELKEDLAALEKLMSSMPEKSRASISGTLRRLP KELSEEKQTRRRRIKPSDENIFKVYFADHTYSTLRLAISASAEETVQSTAEKLCLGEDLVLCEVKSTGER VVLKESDVSVTTGLSLNGRLFIAPREHLDSLTPLPEQEGPKQSTCATIELMSSREMAYQMTLYDWELFNC VHENELIYHIFGRHKFGKITSNLDLLLRRFNEVQFWVVTEMCLTPQVGKRVQLLRKFIKIAAYCKEYQNL NAFFAIIMGLGNIAVSRLSQTWERLPNKFKRMFAEFESFMDPSRNHRVYRLAMSKLQPPIIPFIPLLMKD MTFTHEGNKTYYDGLVNFEKMHMISSTIRTIRQCGSEPFNFDPPPVVKNIQEVRNYVRSLNVIDNQRTLT QLSHKLEPRRS >Strongylocentrotus purpuratus_(XP_784278) MEMLLSHRVITVPPPPPKTALLHPESSPSVDSQGRSRRSSRKSRSPSPQRTSPARTHDGLDPIHPALPIV KVPSDKQSHTGTIFRTLILAKSPNLIKDRKNNLRTYRKCMVGSEMVDWLMQQGQMTLVRSRPQAIGMWQA LLEEGVITEVNREHPFQDAEHQYRFREDDLGITSTPTSSQKKAAEEELPEIVGILAKVAPDAMMRLILRK PPQERSVDDLEIIYEELLHIKALAHLSGMVKRQLTSVLVFECHEKAGTVLFHQGDEGRSWFIILRGSVNV VKYGKGVVCTLHDGDDFGKLALVNDAPRAASIVLREDNCQFLRVDKYDFNRILRDVEANTVRLKEHGQDS LVLEKIPTSTQHSNNNKHHHVSYRYSVMAGVPEKMLEHLLETRIDSKYDPTDTFLEDFLLTHIVFMPSEK LCPALLQHYHSERTSSRGPEQETIDHIVNNKRRVVQLVCLWHVVAGYAFKQDTTIMQFLETLFSAVCDDC PAYPSLQDPLASLEQVLKAVKSTKDSGSHTWQVQTQVLSESRTHQEDELRRTPIKAKDETIFKVYCADHT YTTLRVHMDTSVTNIIQTVSEKMCLGNDLVLCEVKSSGERLSFHQKDVCIATSLSCNGRIFITLRDHLDA LTPLPEQEGPSEGSVSFLEPTSSRELAYQMTMYDWQLFLCTHECEFIYHTFGRHKYRRITANLDVFLRRF NEVQSWIVTELCLTSHISKRVHLLKKFIKIAAHCKEYQNMNSFYAIIMGLSHMSVSRLAQTWDKLPNKLK RVFSDFEALMDPSRNHRVYRLALSKMRPPIIPFMPLLIKDMLFTHEGNKTYFEGLVNFEKMHLVASIMRV VKYCRSENFKLDSPPAVKNVKEIVSYVRNLQVIDNTKRLMQLSYTLEPPKT >Drosophila melanogaster_(FBpp0302889) MDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGR FWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELL RVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPNPALPI TETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTR AQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHI REALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIF VFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPR AATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKY TVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHE DAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEET SIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYC ADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTG LSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHE YELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAY CKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFV GKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEP PSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTRKL >Apis mellifera_(XP_392340) MHRPPHPHPITDHRQVNLVFDDTFSQGLTGRPELYQKSNRSSHSSDTSSAYSGSDTMTSVQGSLDADPDA DDVDLSGLVESIVDSDEEEDLAESMDSLTVRDPVRECLEKDPMERTEDDIETLLEFTQQLKAFTNMTLAV RRALCAVMVFAVVERAGMIVLNDGEELDSWSVLINGAVEIEHSNGEIEQLHLGDSFGILPTMERLLHRGV MRTKCDDCQFVCVTQADYFRIQHQGEENTRRHEENGRVILVTELRGALDGGARRGHVVIRGTPERLMLQL IEENSITDPTYIEDFLLTHRTFIDSPLLVASQLLEWFDQAQVRDRVARVVLLWVNNHFTDFETDPAMMEF LEAFEAGLEREKMQGQQRLLNIACAAKARTRNVTLARPTRDEVLHFSILGGYERGFGIFISKVDKKSKAE DVGLKRGDQILEVNGQSFEHVNHARALEILRGSTHLSITVKSNLLAFKEMLQMPDDSPRPRGRANKSEIS RLQSDPRARLSTHVDTVTPVNPLNPLVGGVPLLIPDSNVSPCKDAKKEHKGFMTLGPKKKLQKALIKMNI LPKNTINDGVHVDDPLAPPHTPPGTGGLAQTTNLYHSKSNPDLTSLYCYDDLRAPDYPEHVLKVYKADQT CKYLLIHKETTAHEVVMLALQEFGITEGSSNFSLAEVSVGEGGMIKQRRLPDQLQNLAERIGLSSRYYLK TNGISETFVADEQAPELIRESQVHFLQLNAVEVAIQLTLQDFSIFRQIESTEYVDDLFELKSRYGVPMLR QFAELVNREMFWVVTEVCSEHNLVRRSKIIKQFIKIARQCKECKNFNSMFAIVSGLGHGAVSRLRASWEK LPSKYQRLFSDLQELMDPSRNMSKYRQLVASEQTQPPIIPFYPVVKKDLTFIHLGNDSRVEGLVNFEKLR MIAKEVRTLTNMCSSPYDLSIMLERGGQPPSSAMVALNQMTTGNQGGQTATVKRRKKSTAAPNPKKMFEE AQMVRRVKAYLANMKVITDEERLHALSVECEPHAGAAAVAAVPLNASRGRRHPSPTLSTTSSASSTSEGR KSIQGTKFGAASPQAVRKMLALSDPHKTRPYQPKHCPPPLPVPGLALHSSGLEPSPGAPRRVGSGSRVPM HERSHSDTPSSLPPPVDLSAESSSVTSLSNLQPLRKTLTSGSVTSSDSGHSTQLDSHSGSSVEAGGSPPP PQRRHSAMQGSVLRGGAPPFPHAVAVLPPLPANHNQNHNHNHHHHHHHHHHHHHHQHYYDHHHHQPQNPQ GFSGTTGLGVGLGVPAALPPPGAGTTIMTTMTTMTTMTSMTTMRPGIGSAQCRQPPAYKVAAQMARLHRL GRAHSHEGVTYRNDHEDDDEESAQVSAV >Anopheles gambiae_(XP_308514) PCDRNLRDCELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRYWYAVLGGQLEVRY HAADTKDGKLSVTLCNLGVGATFGESILHDLPRDSTVVTKTTCELLRVEQQDFRLIFEKNKELMNDIITN CRLKNGFGQSMQTTSTVQTNVQQQPSPTKKQLSPDHPNPAAPITEIPSPAMSRMGWALRTLLVSDNTSCL KDRKVGGKFIRKCAPGTELVEWLLNLSPIVHTRTQAAGMWQALLEEGVLCHVAKEQPFKDKCFLYRFKSD EDGTAGGAPTSDDVNHANEHIREALPALLHRGPDATLRMILRKPSHERTQEELELVYEELLHIAALSHLS TSIKRELASIIVFEAHAHAGTVLFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKEGDDFGKLALINDAP RAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLILERVAKQRGYSAFKYTVMSGTPQKM LEHLLETRLGGQAGPNDPFLDDFLLTHIVFMPTPLLIDELAANYHADADIDLRQASEEDQEYFLTSKRRV VQFIQRWVLAVRHAVFDDPLAVEFIEELATDVEAEPALQEEASIIHHVLTQLSRYQEDRQMNATQKWKLP PNGQPICLFSGNTHSKTVIRPDDDIIFRVYCADHTYCTLRFPMATTAEVIKACAADKLQIARLPEDLLLV EVKSSGERVVFKDNDVSVPTALSLNGRIFVSPKDHLDALTPLPEQEVPTEAPDVDFEALSTKDVAYHMTL FDWDLFWAVHEYELLYHTFGRHHFNKITSNLDVFIRRFNEIQYWVVTEIVSTTNLTKRMSLVKKFIKLAA FCKEYQNLNAFFAIVMGLSNTAVSRLSMTWDKLPSKFRKLFTEYEALIDPSRNHRAYRMSVGKLQPPVIP FMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRAVRFCRSRHLVLDPPSPKNENEIRNYIRCFRTI DNQRVLNSMSQKVEPRRS >Caenorhabditis elegans_(T20G5.5) MERIVSRVRRLSPLHTFSDALLISLLSESDFQPDSIQQGVVLFEKDEPTEYWYLLLSGEV QLYSKTYTGDFNHLKTLRCGALFGDLSTLTHSCSCLVTRPAQLIRIAQNHFLSVYNKHGD HLQPFIIIMHDILTDETPSDPIHPHSSGLFNGQRSMDLISTEINPSEIVSVSTNGMLSKM ILPSIPNQREKPMNRVVVNQQKNEERNFIEFHNPTGIEKQIRDSGGILHRKMLTDNHQVI RDITTEHTRVQNCMIGAEMIDWLLTLFVSTSTTCSSLSRIQMSAIWQVLLNNGLISHIDG EHQFLDKTNSYYRWVQQFRSRNKVAPSIEEVSKSITLLSSVAPETLFLMIVSKPGFERSP EELEVVYEELTFIKALSHLSTMVKRQLSNFVKVEQYVHAGSVVFRQGEIGVYWYIVLKGA VEVNVNGKIVCLLREGDDFGKLALVNDLPRAATIVTYEDDSMFLVVDKHHFNQILHQVEA NTVRLKDYGEDVLVLEKVDIPRGAALENSNSCNFNCGYSVMAGKAEKILEYVLETRIDAL GDDISELDVFVEDFILTHDAFMPDNTVCNFLKSYYFRTPYRATRDSITDSCTEEVRCKRR VVQFVYVWCSLLRVNFFLNPVTNSFVEELFCHVIDDRKRLGGMEDILTRIGSIRSTRENM QLVLARHPAIVLDCGVLSAHTPCPVLPSDVCNQIIYLADTTCFVLPIRVDKTAEEICELS RRRMSFSAEPLNLVEVKSNGEKLIFSPNDRAIPTVLSLNSKLYVVNREEIPLLVPMEDQN GPTPSSHSSILHLIDSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPFNLDLL VRRFNEVQHWSTTEILLATEENRMEILKKFISIATIAREYRDLLTVFAITLGLSHTSISR LTLTWSKLPPASLKTFSELENLLDPTRNHRMYRLLVSKMSSPYIPFVPLILKDLMFIHQG NKSFYNGLVNFEKMHMFAKIFRSFRQCKSQMDNGAEHEFIEPQSLIRNLRVIDNQKKLMQ LSYEIEPKSAPKRNVIFH >Nematostella vectensis_(XP_01629461) DLMVNMVYLQNELVFKKVHPHVVRQICFYAYYEDLEPGTVLYRQDAKGLNWYAILTGSVNICVSQTSKIE DAVTLCCLGPGSTFGESVLDGSPRTATAITNDYCELLCVNGEYLKTIFQQNRRYLVGIELPGEQCNTVEV TEADGESTLKLELQLKLSQIMLNAAVVLHNKMVKSAPHLFKERSCNSGTFPDCFAGSEAVDWLLDSSRQV HSRFHAVSVFQALLEEGRDHHNLDQRDHHYRNQCDHHYRDQRDHITVTSVTIITVTSVTIITATSVTIIT VTSVTIIGVISVPNARSQEDVDTIYEELLRIKSLSYISSTVKKEMAAAVVLESCEHKGTVLFNQGDEGDS WYIILKGSVNVVVLGKGIVCQLHTWDDFGRLSLVNNAPRAASIETCEDNCHFLRVSKETFDNILKDVESS SLVLKEHGSDVLVLEEFKDRVPVNEKGQFKEKSYYAVMAGTASKMVDYLLQIPTNKETEKIVNNVFLYRH RSPSQRSLSLSFSTHQHHHQNNYYHHHHHHHHQHRHLQRMLRVSWEFRGSKGLFMTSAEDFCIRRLVYTF LAHSCNTAFLCYILENRPTMKKSRHMFQRNIVFQRRTMSFSSRRGGTADLKQPRRSKMTPIEKDDYVTFR VYCADHTYSTVRMRYGDTAQMIVDTAKERLLLGDDCVLCEVKSSGERLVFQGNEISVITRISINSKLFIA PKEHIDSLTPLMEQEGPECGTRLIEVISSREIAYYLTQYEYELFERCNIYEFIYQSFDREKFGQISANLD ICLSRFNEVHYWVITEICLATQLSKRVFLLKKFIKIASYCKDYKNLNSAFAIIMALNCAAISRLTQTWEK IPNKYKKLYRELDAILDPSGNHRVYRLVVAKMKPPVIPFMVLIMKDITIINYGNKTFVNELVNFEKMRMI TISLRLVEYCRSAPFDTPAPSSLKIPSEVPSYVRNLQVIDNGKTLTQLSYRLEPPTNN >Hydra magnipapillata_(XP_02155415) MDSDDEILPNESAAVRDIVRDCLEKEPGERTENDINILMDFMQRLPAFNKLTHNIKVEMCKVMVFAVVDE AGAIVMSDGEEMDSWSVILNGSVEILYEDQPPKTLHLGDSFGVKTTQEQMFHKGVMKTRVDDCQFVCIAQ NEYWRIFSHGEASCRKVEEEGEVVMVTEHRVQDGGSRQGQVVIKGTPERLLDHLMEDHSVIDPTYVEDFL LTYVVFFNKSHDIASKLLKWFERPQLKDKVTRVMLLWVNNHFSDFEGDVFMESCLERFEYLLEAKKMLGQ LRLLNMACSAKSKPRIINLQRLSKETHLDFSICGGREKGFPIFVSKVNYDSKAAELGLKRGDQIIEVNAQ ALDQFSCSKAIDFLMSNAHLCLTVKTNTIGFKEVIQPTAKKTQSSHGSLDETVLSQQIGALDLRVSNNKL GTSTISRSSSDVNNVKGNKKAKNFSDMTDSLASISGSSTLPKNSKLKRAMLKFSFMPRSPSERELNKLDY QDSTQPFTRSFTKPSQDSHNQTNADDNHSTDDEYEDTVIKVYRSDHTSKFFILRKDTIAKQVVISALEAF GITDYASKSYFLCEVTVTEDGLIKQKRLPEKTSNLASRISLNSRYYIKASISEGPISDEVAQEIAREANF NLLQLTPLDVAKELTLQDFDLFRNVDSREYIYNLFESNNERKSKNLRCVEQTTNTEMFWVISEICLESNI AKRVKLLKYYIKVAKYCKDFKNYNSMYAVISGLANTAISRLKHTWEKLPQKHEDMFQDLLDLMDPSRNMS KYRNMFTGEQCYPPIIPWFPIVKKDMTFLHLGNDTHVDGLVNFEKLRMIAREVRRVYNPGENNVALSVVS IMTGAPNRRSGRGFVKDPKKTYEEIQTSRKIRQYLEKLSSRHYTEKELIEMSYNCEPPLTLTAPGVSQRS RSKPPPLTNSNKSAEDKSESSRTNSVSSLESTVTSNQPPRRKLPTPTSSTTSAETSSLPGSRNFRPPYSF TANEDQVDSVLYDNGVEQLSGVEKFPEDLLIRNKWIVAICSKHFIQESYIVCGWSSKKQLKKDAILGIK