>Homo sapiens_IHH(ENSP_295731)
MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKT
LGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMN
QWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYY
ESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTF
SDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQP
GQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLA
FWPLRLFHSLAWGSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS

>Mus musculus_IHH(ENSMUSP_128056)
MESPRATQTPESPKLSQPRAHLSAHQAPSPAALPGYPAMSPAWLRPRLRFCLFLLLLLLV
PAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELT
PNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEE
SLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGG
CFPAGAQVRLENGERVALSAVKPGDRVLAMGEDGTPTFSDVLIFLDREPNRLRAFQVIET
QDPPRRLALTPAHLLFIADNHTEPAAHFRATFASHVQPGQYVLVSGVPGLQPARVAAVST
HVALGSYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFPSLAWGSWTPSEGVH
WYPQMLYRLGRLLLEESTFHPLGMSGAGS

>Rattus norvegicus_IHH(ENSRNOP_24419)
LESPRATQTPESPKLCQPRTHPSAHQAPSPVALPGYPAMSPAWLRPRLRFCLLLLLLLLV
PAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELT
PNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEE
SLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGG
CFPAGAQVHLETGERVALSAVKPGDRVLAMGEDGNPTFSDVLIFLDREPNRLRAFQVIET
QDPPRRLALTPAHLLFIADNHTEPAARFRATFASHVQPGQYVLVAGVPGLQPARVAAIST
HVALGSYAPLTRHGTLVVEDVVASCFAAVSDHHLAQLAFWPLRLFPSLPWGSWTPSEGVH
WYPQLLYRLGRLLLEESTFHPLGMSGAGS

>Bos taurus_IHH(ENSBTAP_11124)
LEPPGATRTPEPPQRSGLLVHPSAHQASSPAAPRGSPAMSPARLRPRLRFCLLLLLLLLL
VPAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKEL
TPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSE
ESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTG
GCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGNPTFSDVLIFLDREPDRLRAFQVIE
TQDPPRRLALTPAHLLFTANNHTEPAAHFRATFASQVQPGQYVLVAGVPGLQPARVAAVS
THVALGAYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAWGSWTPGEGV
HWYPQLLYRLGRLLLEEGSFHSLGVAGAGS

>Gallus gallus_IHH(ENSGALP_18493)
MKPARLLLLLSGCALLLAPAVRCCGPGRVVGSRRRPPRKLIPLAYKQFSPNVPEKTLGAS
GRYEGKIARNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPG
VKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGMLARLAVEAGFDWVYYESKA
HIHCSVKSEHLVAAKTGGCFSGRALATLENGARTPLWALRPGQRVLAMDGAGRPTYSDFL
AFLDKEPRALTAFHVIETRQPPRRLALTPTHLLFVADNASAPAAQFRPTFASHVQPGHFV
LVAVGSGGLQPAEVVGVRGRTDVGAYAPLTRHGTLVVDDVVASCFALVREQQLAQMAFWP
LRLYHSLLGGPGVQGDGVHSYSGLLYRLGRMLLPPDSFHPLGAPRAES

>Danio rerio_IHH(ENSDARP_76101)
MRLPVVFGLLVGCALIFAPVNEGCGPGRGHGKRRPPKKLTPLNYKQFSPNVAEKTLGASG
RIEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNMWPGV
KLRVTEGWDEDGNHFEDSLHYEGRAVDITTSDRDRNKYGMLARLAVEAGFDWVYYESKAH
IHCSVKSEHSVAAKTGGCFPASALVTVEDGSLKTLDSLQPGEKVLASSESDGSGTLVYSE
VIAFLDRDPSARKQFFTIETDSGAKLSLTAAHLLFVSEGNCSGSAANAELRSVFASDVLP
GQCVVSTQAAGQHGRLSRVSRIQMQEDRGVFAPLTSHGTVVVNGIVSSCYAAVDQHWLAH
WAFGPLRVLYNWGGPVGHQVTGIHWYSSLLHWIGTQVLDPAHFHPWSMMDNDR

>Takifugu rubripes_IHH(ENSTRUP_34503)
VLLFLLAPASEGCGPGRGYGKRRLPKKLIPLAYKQFSPNVAEKTLGASGRPEGKITRNSE
RFKELTPNYNTDIFFKDEEETGADRLMTQKHTHTDLLHVFGSGLSKKTPFLPSLCCLQRC
KDKLNSLAISVMNMWPGVKLRVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYAMLA
RLAVEAGFDWVYYESKAHIHCSVKSEHSVAAKTGGCFSGDAQVVLEGGVTKPMRDLRPGD
RVLSSSATEGLGPFIYSPVLSFLDRRPNVTSVFYTIGTVAGHSITLTAAHLIYVTDCVWN
ETYGDLYLDPAQEVGFSRDRGLRIVFASEVQPGQCVLTSGGKVGSQATFSPVTFVRAQRS
TGLYAPLTEHGSIVVNGVLASCYAAVDSHRLAHWALAPLRLFYTLLGPSGSQTDGLHWYP
WLLQRLGTMLLDTEHFHPWGV

>Tetraodon nigroviridis_IHH(ENSTNIP_19547)
MRISFLRLTASLCALVLLFLLAPASEGCGPGRGYGKRRLPKKLIPLAYKQFSPNVAEKTL
GASGRPEGKITRNSERFKELTPNYNTDIIFKDEEDTGADRLMTQRCKDKLNSLAISVMNM
WPGVKLRVTEGWDEDGHHSGDSLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYE
SKAHIHCSVKSEHSVAAKTGGCFHGDTQVILEGSVTKPMRDLRPGDRVLASSGGGGPLVY
SSVLSFLDRQPNATSVFYTIGTDAGHRITLTAAHLIYVTDCAWSGTHGEPYLDSVQGGRS
SRDRGLRIVFASEVRPGQCVLTSGGKLGSPATFSPVTFVHVRRSTGLYAPLTEHGSIVVN
GVLASCYAVVDSHHLAHWALAPLRFFYALMGPSGSQTDGLHWYPWLLQRLGTTLL

>Gasterosteus aculeatus_IHH(ENSGACP_20527)
MRIPFHLLTASLCATAPASEGCGPGRGYGKRRPPKKLIPLAYKQFSPNVAEKTLGASGRP
EGKITRNSERFKELTPNYNTDIIFKDEEDTGADRLMTQRCKDKLNSLAISVMNMWPGVKL
RVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYQSKAHIH
CSVKSEHSVAAKTGGCFPGDAQVTLSGGVTKRMQDLRPGDHVLASSTTDGHGPLIYSPVS
SFLDYQPNVTKTFCRIGTDTGLIITVTAAHLIFVTDCTGAKSREAGVRTVFASEVRPGQC
VLTSHGKAGSRASLSVVTFVEEQGGTGLYAPLTQHGSIVVNGVLASCYAAVDNHHLAHWV
LTPLRFFYSLMGRSEPQSHGLHWYPRLLQRLGKTLLGAGHFHPWGTEQGHR

>Oryzias latipes_IHHa(ENSORLP_2065)
MLLTTLVTCLAGCAMLLSPASEGCGPGRGHGKRRSQRKLVPLSYKQFSPNVAEKTLGASG
RYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNLWPKV
RLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYESKAH
IHCSVKSANXTFAKKKGGFVLMVTTALRDGYGLPAGEKWIFCAAHSETIFSHLIIILELD
LPKTKXFYTLQTEAGPELSLTAAHLLFVSEGNCSEGTVPGPGALKTVYASDVQPGQCVLV
LGGQSGCLSRVNRVSVAVKRGVFAPLTQQGTVVVDGVLASCYAAVNQHLLAHWSFSPLRL
MHSWTGSTGGHSEGLHWYAQLLYWLGRKLLSSGHLHPLAVAQDNR

>Oryzias latipes_IHHb(ENSORLP_20229)
PPGAMRISLFLLTASLCALVLLLAPALEGCGPGRGIGKRRFPKKLIPLAYKQFSPNVAEK
TLGASGRPEGKITRSSERFKELTPNYNTDIIFKDEEDTGADRLMTQRCKDKLNSLAISVM
NMWPGVKLRVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYNMLARLAVEAGFDWVY
YESKAHVHCSVKSEHSVAAKTGGCFPGDAQVFLEGGGTKQMRHLLPGDRVLSSSTKDGHT
SLLYSPVISFLDRQPNIMKTFYIIGTDAGFNISLTAAHLIFTADCADGGNKTKPQETFFP
SIWTDRGRSGAHLRTVFASQVQPGQCVYTSSEESEPHVRISVVTFVEEQRSTGLYAPLTQ
HGSIVVNGVLSSCYAAVDSHELSHWAFAPLRFLYSMLGSSQAQSDGVHWYPRLLHRLGEL
LLDAGHFHPWGI>Homo sapiens SHH
MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV
KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAH
IHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLT
FLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALG
PRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVL
ASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGA
ADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS

>Mus musculus SHH
MLLLLARCFLVILASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGAS
GRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPG
VKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKA
HIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDFL
TFLDRDEGAKKVFYVIETLEPRERLLLTAAHLLFVAPHNDSGPTPGPSALFASRVRPGQR
VYVVAERGGDRRLLPAAVHSVTLREEEAGAYAPLTAHGTILINRVLASCYAVIEEHSWAH
RAFAPFRLAHALLAALAPARTDGGGGGSIPAAQSATEARGAEPTAGIHWYSQLLYHIGTW
LLDSETMHPLGMAVKSS

>Rattus norvegicus SHH
MLLLLARCFLVALASSLLVCPGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGAS
GRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPG
VKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKA
HIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFL
TFLDRDEGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSGPTPGPSPLFASRVRPGQR
VYVVAERGGDRRLLPAAVHSVTLREEAAGAYAPLTAHGTILINRVLASCYAVIEEHSWAH
RAFAPFRLAHALLAALAPARTDGGGGGSIPAPQSVAEARGAGPAAGIHWYSQLLYHIGTW
LLDSETLHPLGMAVKSS

>Canis familiaris Shh
DEMLLLARCMLAVLVCALLMCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGA
SGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWP
GVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK
AHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLRPGDRVLAADDQGRLLYSDF
LTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPLNDSARVRPGQRVYVVAERGGD
RRLLPAAVHSVTLREEATGAYAPLTAQGTILINRVLASCYAVIEEHGWAHRAFAPFRLAH
ALRAADAPGAAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS

>Gallus gallus SHH
MDEMLLLTRILLVGFICALLVSSGLTCGPGRGIGKRRHPKKLTPLAYKQFIPNVAEKTLG
ASGRYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQW
PGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYES
KAHIHCSVKAENSVAAKSGGCFPGSATVHLEHGGTKLVKDLSPGDRVLAADADGRLLYSD
FLTFLDREDSSRKLFYVIETRQPRARLLLTAAHLLFVAPQHNQSEATGSTSGQALFASNV
KPGQRVYVLGEGGQQLLPASVHSVSLREEASGAYAPLTAQGTILINRVLASCYAVIEEHS
WAHWAFAPFRLAQGLLAALCPDGAIPTAATTTTGIHWYSRLLYRIGSWVLDGDALHPLGM
VAPAS

>Xenopus tropicalis SHH
MLVVTRILLLGFICTLVAPPGLACGPGRGIGKRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKITRNSDRFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV
KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYFESKAH
IHCSVKA
>Tetraodon nigroviridis SHH
MLLWTRIVLVGLLCLSLVSSGMGCGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQRRVETAAALWECFEHYRDLK
NGWNSVKAHGDDGFLIARRCKDKLNSLAISVMNQWPGVKLRVTEGWDEDGHHFEESLHYE
GRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAHIHCSVKAENSVAAKSGGCFPGS
STVTLQDGTKKLVKDLQSGDRVLAADGDGNPTYSDFITFIDRDSATRRLFHVIETDSGQK
ITLTAAHLLFVARNGSGGDGMSAVFASQVRRGQKVMVSDPERGRLAPVTVKRIYTQEHVG
SYAPVTVQGNVVVDEILASCYAVIEDHDLAHWALAPVRLAHWVSSLLSSSQPGGGGQRDG
VHWYSRLLYQVGTWLLDSQAIHPLGMSVSPS

>Danio rerio SHH
MRLLTRVLLVSLLTLSLVVSGLACGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNHWPGV
KLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAH
IHCSVKAENSVAAKSGGCFPGSALVSLQDGGQKAVKDLNPGDKVLAADSAGNLVFSDFIM
FTDRDSTTRRVFYVIETQEPVEKITLTAAHLLFVLDNSTEDLHTMTAAYASSVRAGQKVM
VVDDSGQLKSVIVQRIYTEEQRGSFAPVTAHGTIVVDRILASCYAVIEDQGLAHLAFAPA
RLYYYVSSFLFPQNSSSRSNATLQQEGVHWYSRLLYQMGTWLLDSNMLHPLGMSVNSS

>Danio rerio twhh
MDVRLHLKQFALLCFISLLLTPCGLACGPGRGYGKRRHPKKLTPLAYKQFIPNVAEKTLG
ASGKYEGKITRNSERFKELIPNYNPDIIFKDEENTNADRLMTKRCKDKLNSLAISVMNHW
PGVKLRVTEGWDEDGHHLEESLHYEGRAVDITTSDRDKSKYGMLSRLAVEAGFDWVYYES
KAHIHCSVKAENSVAAKSGGCFPGSGTVTLGDGTRKPIKDLKVGDRVLAADEKGNVLISD
FIMFIDHDPTTRRQFIVIETSEPFTKLTLTAAHLVFVGNSSAASGITATFASNVKPGDTV
LVWEDTCESLKSVTVKRIYTEEHEGSFAPVTAHGTIIVDQVLASCYAVIENHKWAHWAFA
PVRLCHKLMTWLFPARESNVNFQEDGIHWYSNMLFHIGSWLLDRDSFHPLGILHLS

>Takifugu rubripes SHH
MLLWTRIVLVGLLCLSLVSSGMGCGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNQWPGV
KLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAH
IHCSVKAENSVAAKSGGCFPGSSTVTLQDGTKKLVKHLRSGDRVLAADDDGNPTYTDFIM
FVDRDSTTRRLYHVIETDSGQKITLTAAHLLYVARNGTEGDGMSAVFASQVRRGQKVIVS
DPERSRLEPVTVERIYTQEHVGSYAPVTVQGNVVVDEILASCYAVIEDHDLAHWALAPVR
LAHWVSSLLSRSQPGGGGQKDGVHWYSRLLYQVGTWLLDGHAIHPLGMSVSPS

>Gasterosteus aculeatus SHH
MLLWNRIVLVGLICLSLVSSGMGCGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNQWPGV
KLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKAH
IHCSVKAENSVAAKSGGCFPGSSTVTLQDGTKKAVKHLQTGDRVLAGDVEGNPTYTDFIM
FIDQDSTTRRLFHVIETDSGQKITLTAAHLLFVGRNATAGERMSAVFASQVRSGQKVFVF
DAERSRLEPVTVRRIYTREHEGSFAPVTAQGTVVVDQVLASCYAVIEDHDLAHWALAPVR
LAHWVSSLLFRSQRGASAQSDGVHWYSKMLYQVGSWLLDSHSIHPLGMSVYSS

>Oryzias latipes SHH
KMLLWAKFVLVGLFCLSLVSSGMGCGPGRGYGRRRHPKKLTPLAYKQFIPNVAEKTLGAS
GRYEGKITRNSERFKELTPNYNTDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNQWPG
VKLRVTEGWDEDGHHFEESLHYEGRAVDITTSDRDKSKYGTLSRLAVEAGFDWVYYESKA
HIHCSVKAENSVAAKSGGCFPGSSTVTLENGTQRPVKDLQPGDRVLAADYDGNPVYTDFI
MFIDRDSSTSRIFYVIETESGQKVTLTAAHLLFIAHNSTQAERRMSAVFASQVRPGQKVF
VFGRGLLAPVTVKRIYTQRHEGSFAPVTAQGTVVVDQVLASCYAVIEDHSLAHWALAPVR
LAHWVSSLLFGSQPRVSAQSEGVHWYSKILYQLGTWLLDSHSIHPLGMSVSPS



>Homo sapiens DHH
MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGAS
GPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG
VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN
HVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVL
LFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV
LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL
RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG


>Mus musculus DHH
MALPASLLPLCCLALLALSAQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGAS
GPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG
VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN
HIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVL
LFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV
LAPGGDALQPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL
RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELMG




>Rattus norvegicus DHH
MALPASLLPLCCLALLALSVQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSMPERTLGAS
GPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPG
VRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRN
HIHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVL
LFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSV
LAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPL
RLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELMG

>Bos taurus DHH
ASMALPASLVPLCCLALLALPAQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSVPERTLG
ASGPAEGRVTRGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMW
PGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYES
RNHVHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTP
VLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGD
SVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFA
PLRLLHALGALLPGGAVQPTGMHWYSRFLYRLAEELLD

>Danio rerio DHH
MTLAPWLRLARLGLLTVCLYSWLVVDGRGPGPGYGGRHRQRKLTPMSYKQYVPGVSENNL
GASGRAEGRITRSSERFNELVCNYNTDIDFKDEERSNADRFMTKRCKDCLNKLAIAVMNQ
WPGVRLRVTEAWDEDGHHPPGSLHYEGRAVDITTSDRDTKKYGLLAQLAVEAGFDWVHYE
SKYHVHCSVKADHSVAVEKGGCFSASGLVTMADGVQKPMSCLWPGEKVLSVSGSGEVVFS
RVLLFLHLDRESRTSFFIITTENEKRIALTPNHLIFAAHNLKLHHHDYETVFARNVRIGD
YILTTGGDRGIQPSKVVSVSLEERMGVYAPLTEHGNLFVDGVLASNYATFQDHGLAHTVF
WPFRVLFVFFNKEMEEDLQRVAVPYICSTNQTILTSVMHSRLSSVFKWQDATRAEMENAF
LQQKEVYWYARLLHTLGRIFLDPQRFY

>Gasterosteus aculeatus DHH
PQPSPMKQSLWARLAQVGLLAVWTCVWLVQGCGPGPGYGIRSRTRRLTAMHYKQFFPNFS
ENNLGASGRAEGKITRNSERFNELVCNYNTDIVFKDEENTNADRFMTKRCKDCLNRLAIA
VMNQWPGVHLRVTEAWDEDGHHPPGSLHYEGRAVDITTDDRETEKYGLLAQLAVEAGFDW
VHYESKYHIHCSVKADHSVAVEKGGCFPGWARVTVAGGVQKSLSSLAAGDRVMALSGTGQ
VVLSQVLLFLHQDHESWSTFLSLETEDGHRLALTPHHLVFLSSHCRLDSSEYEAQFASRA
KTGDCVLIHTAEAQVRPSRIISVSEEESVGVYAPLTEAGSVFVEGVLASCYALMDDHRLA
HWAFGPVRLLSSFNHLLWEETRHVHWYAELLYSLRWTFLDSNSFYP

>Oryzias latipes DHH
MKQFCWARLVQLCLLAAWTCVWLVEGCGPGPGYGIRSRPRKLTAMHYKQFFPNFSENNLG
ASGRAEGKITRDSERFNELVCNYNPDIVFKDEENTDADRLMTKRCKDCLNRLAIAVMNQW
PGVHLRVTEAWDEDGHHPQGSLHYEGRAVDITTDDRETEKYGLLAQLAVEAGFDWVHYES
KYHVHCSVKADHSVAVERGGCFPGWARVTLAGGRQKTLSSLAPGDRVMALSDTGQVVYTR
VLSFLHQDQESVSTFLSLETEEGYTLVLTPHHLVFLAPNCGHDISEYQARFASRAKTGDC
VLISTADSQTLPSPIVSVSVAESVGVYAPLTEAGTLFVDRVLASSYALVEDHRLAHWAFG
PLRLFYSLKELLWAEAADQTTTGSISLTNIRSHFSTLTIKHNNLTEPFRMKIQEKRLSKI
HWYARLLYRFAWVLLDSNLFYP

>Homo sapiens IHH
MSPARLRPRLHFCLVLLLLLVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKT
LGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMN
QWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYY
ESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSPTF
SDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTADNHTEPAARFRATFASHVQP
GQYVLVAGVPGLQPARVAAVSTHVALGAYAPLTKHGTLVVEDVVASCFAAVADHHLAQLA
FWPLRLFHSLAWGSWTPGEGVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS


>Mus musculus IHH
MESPRATQTPESPKLSQPRAHLSAHQAPSPAALPGYPAMSPAWLRPRLRFCLFLLLLLLV
PAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELT
PNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEE
SLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGG
CFPAGAQVRLENGERVALSAVKPGDRVLAMGEDGTPTFSDVLIFLDREPNRLRAFQVIET
QDPPRRLALTPAHLLFIADNHTEPAAHFRATFASHVQPGQYVLVSGVPGLQPARVAAVST
HVALGSYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFPSLAWGSWTPSEGVH
WYPQMLYRLGRLLLEESTFHPLGMSGAGS

>Rattus norvegicus IHH
LESPRATQTPESPKLCQPRTHPSAHQAPSPVALPGYPAMSPAWLRPRLRFCLLLLLLLLV
PAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKELT
PNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSEE
SLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTGG
CFPAGAQVHLETGERVALSAVKPGDRVLAMGEDGNPTFSDVLIFLDREPNRLRAFQVIET
QDPPRRLALTPAHLLFIADNHTEPAARFRATFASHVQPGQYVLVAGVPGLQPARVAAIST
HVALGSYAPLTRHGTLVVEDVVASCFAAVSDHHLAQLAFWPLRLFPSLPWGSWTPSEGVH
WYPQLLYRLGRLLLEESTFHPLGMSGAGS

>Gallus gallus IHH
MKPARLLLLLSGCALLLAPAVRCCGPGRVVGSRRRPPRKLIPLAYKQFSPNVPEKTLGAS
GRYEGKIARNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPG
VKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGMLARLAVEAGFDWVYYESKA
HIHCSVKSEHLVAAKTGGCFSGRALATLENGARTPLWALRPGQRVLAMDGAGRPTYSDFL
AFLDKEPRALTAFHVIETRQPPRRLALTPTHLLFVADNASAPAAQFRPTFASHVQPGHFV
LVAVGSGGLQPAEVVGVRGRTDVGAYAPLTRHGTLVVDDVVASCFALVREQQLAQMAFWP
LRLYHSLLGGPGVQGDGVHSYSGLLYRLGRMLLPPDSFHPLGAPRAES

>Bos taurus IHH
LEPPGATRTPEPPQRSGLLVHPSAHQASSPAAPRGSPAMSPARLRPRLRFCLLLLLLLLL
VPAARGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPEKTLGASGRYEGKIARSSERFKEL
TPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISVMNQWPGVKLRVTEGWDEDGHHSE
ESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWVYYESKAHVHCSVKSEHSAAAKTG
GCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGNPTFSDVLIFLDREPDRLRAFQVIE
TQDPPRRLALTPAHLLFTANNHTEPAAHFRATFASQVQPGQYVLVAGVPGLQPARVAAVS
THVALGAYAPLTRHGTLVVEDVVASCFAAVADHHLAQLAFWPLRLFHSLAWGSWTPGEGV
HWYPQLLYRLGRLLLEEGSFHSLGVAGAGS

>Danio rerio IHH
MRLPVVFGLLVGCALIFAPVNEGCGPGRGHGKRRPPKKLTPLNYKQFSPNVAEKTLGASG
RIEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNMWPGV
KLRVTEGWDEDGNHFEDSLHYEGRAVDITTSDRDRNKYGMLARLAVEAGFDWVYYESKAH
IHCSVKSEHSVAAKTGGCFPASALVTVEDGSLKTLDSLQPGEKVLASSESDGSGTLVYSE
VIAFLDRDPSARKQFFTIETDSGAKLSLTAAHLLFVSEGNCSGSAANAELRSVFASDVLP
GQCVVSTQAAGQHGRLSRVSRIQMQEDRGVFAPLTSHGTVVVNGIVSSCYAAVDQHWLAH
WAFGPLRVLYNWGGPVGHQVTGIHWYSSLLHWIGTQVLDPAHFHPWSMMDNDR

>Tetraodon nigroviridis IHH
MRISFLRLTASLCALVLLFLLAPASEGCGPGRGYGKRRLPKKLIPLAYKQFSPNVAEKTL
GASGRPEGKITRNSERFKELTPNYNTDIIFKDEEDTGADRLMTQRCKDKLNSLAISVMNM
WPGVKLRVTEGWDEDGHHSGDSLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYE
SKAHIHCSVKSEHSVAAKTGGCFHGDTQVILEGSVTKPMRDLRPGDRVLASSGGGGPLVY
SSVLSFLDRQPNATSVFYTIGTDAGHRITLTAAHLIYVTDCAWSGTHGEPYLDSVQGGRS
SRDRGLRIVFASEVRPGQCVLTSGGKLGSPATFSPVTFVHVRRSTGLYAPLTEHGSIVVN
GVLASCYAVVDSHHLAHWALAPLRFFYALMGPSGSQTDGLHWYPWLLQRLGTTLL

>Takifugu rubripes IHH
VLLFLLAPASEGCGPGRGYGKRRLPKKLIPLAYKQFSPNVAEKTLGASGRPEGKITRNSE
RFKELTPNYNTDIFFKDEEETGADRLMTQKHTHTDLLHVFGSGLSKKTPFLPSLCCLQRC
KDKLNSLAISVMNMWPGVKLRVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYAMLA
RLAVEAGFDWVYYESKAHIHCSVKSEHSVAAKTGGCFSGDAQVVLEGGVTKPMRDLRPGD
RVLSSSATEGLGPFIYSPVLSFLDRRPNVTSVFYTIGTVAGHSITLTAAHLIYVTDCVWN
ETYGDLYLDPAQEVGFSRDRGLRIVFASEVQPGQCVLTSGGKVGSQATFSPVTFVRAQRS
TGLYAPLTEHGSIVVNGVLASCYAAVDSHRLAHWALAPLRLFYTLLGPSGSQTDGLHWYP
WLLQRLGTMLLDTEHFHPWGV

>Gasterosteus aculeatus IHH
MRIPFHLLTASLCATAPASEGCGPGRGYGKRRPPKKLIPLAYKQFSPNVAEKTLGASGRP
EGKITRNSERFKELTPNYNTDIIFKDEEDTGADRLMTQRCKDKLNSLAISVMNMWPGVKL
RVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYQSKAHIH
CSVKSEHSVAAKTGGCFPGDAQVTLSGGVTKRMQDLRPGDHVLASSTTDGHGPLIYSPVS
SFLDYQPNVTKTFCRIGTDTGLIITVTAAHLIFVTDCTGAKSREAGVRTVFASEVRPGQC
VLTSHGKAGSRASLSVVTFVEEQGGTGLYAPLTQHGSIVVNGVLASCYAAVDNHHLAHWV
LTPLRFFYSLMGRSEPQSHGLHWYPRLLQRLGKTLLGAGHFHPWGTEQGHR

>Oryzias latipes IHH_A
MLLTTLVTCLAGCAMLLSPASEGCGPGRGHGKRRSQRKLVPLSYKQFSPNVAEKTLGASG
RYEGKITRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNSLAISVMNLWPKV
RLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYAMLARLAVEAGFDWVYYESKAH
IHCSVKSANXTFAKKKGGFVLMVTTALRDGYGLPAGEKWIFCAAHSETIFSHLIIILELD
LPKTKXFYTLQTEAGPELSLTAAHLLFVSEGNCSEGTVPGPGALKTVYASDVQPGQCVLV
LGGQSGCLSRVNRVSVAVKRGVFAPLTQQGTVVVDGVLASCYAAVNQHLLAHWSFSPLRL
MHSWTGSTGGHSEGLHWYAQLLYWLGRKLLSSGHLHPLAVAQDNR

>Oryzias latipes IHH_B
PPGAMRISLFLLTASLCALVLLLAPALEGCGPGRGIGKRRFPKKLIPLAYKQFSPNVAEK
TLGASGRPEGKITRSSERFKELTPNYNTDIIFKDEEDTGADRLMTQRCKDKLNSLAISVM
NMWPGVKLRVTEGWDEDGHHSEDSLHYEGRAVDITTSDRDRNKYNMLARLAVEAGFDWVY
YESKAHVHCSVKSEHSVAAKTGGCFPGDAQVFLEGGGTKQMRHLLPGDRVLSSSTKDGHT
SLLYSPVISFLDRQPNIMKTFYIIGTDAGFNISLTAAHLIFTADCADGGNKTKPQETFFP
SIWTDRGRSGAHLRTVFASQVQPGQCVYTSSEESEPHVRISVVTFVEEQRSTGLYAPLTQ
HGSIVVNGVLSSCYAAVDSHELSHWAFAPLRFLYSMLGSSQAQSDGVHWYPRLLHRLGEL
LLDAGHFHPWGI

>Branchiostoma floridae HH
MAGVLARWMVTLVAISALGTHWGPSEACGPGGRFGRRRHPRKLTPFVYKQQMPAVSENTFGASGLFNGRI
TRDSERFHTLKQNFNTDIIFKDEEKTGADRFMTQTPHSQIRVLGSVLLGLTAEQVCIYLGVDRNTLQRCK
DKLNALAISVMNQWEGVKLRVTEGWDEDGFHTEESLHYEGRAVDITTSDRDRTKYGMLARLAVEAGFDWV
YYESKAHIHCSVKAESDTTATQGGCFPAESWVTRDDGNRIRMRDVRPGDKVLSMDSGGHPVFSEVLTFMD
RDSRGPWVYYTIHTDDRNITVTATPSHLVFVTESRDLSSPRIAKFMSDARPGEFLLTPDSDGGGFRKVKI
VSVTMREEKGAYAPLTVHGTVVVDNVAMSCYALIESQALAHWVFAPFRLYYQLTSSLWDGPSHDQTLQEG
VHWYPSFFYRYGISLVEPTLLHPTATDS

>Strongylocentrotus purpuratus hh
MVRADMVKWLTVQITTVLCLIALTQACHPGRSGKTSHRPRNRTPLQYKQRVPNISEDTFG
ASGPPEGRINRNDERFNTLSPNNNDDIVFKDKEGTGADRLMTQRCKDKLNTLAISVMNEW
PGIKLRVVEAWDEDQPNVEPLHAEGRAVDITTSDRDKNKYGALARLAVEAGFDWVNYESK
AWVHCSVKSESAAAKNSGGCFPGFSQASLENGRTISMLDIRVGDEVAVVNDDGALDYSDV
IMIVHRKLNDSTLFYVIETEDKSVVQLTPQHLIYVSETESSFSQSKAMFASEVRTNQFVY
TTGQNHDRGVRPKRVVSVTTRLGRTAVAPVTRQGSLVIDDVAISSYAVMRDEWIAHASFA
PVRWYSYIRHNMLGIVDTNTGQEQRVHWYTQRLYKLGKYVMSDRLFLGFDV