>Homo sapiens_GLI2(ENSP_390436) METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHA PLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHP YVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQM TLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSD ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSES AVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKED LDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTRE QKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGC NKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQR NDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGA QSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLR KHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPA GLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASP LGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGP PPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHE APGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLA RGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDE GTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKN NMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDS TQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTIS GALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQS YPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPT GRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAP DHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTV DSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGI SNMAVGDMSSMLTSLAEESKFLNMMT >Mus musculus_GLI2(ENSMUSP_54837) METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAVAAAVAAHGVPQQLLPAFHAPLPI DMRHQEGRYHYDPHSVHSVHGPPTLSGSPVISDISLIRLSPHPAGPGESPFSAHHPYVNP HMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQMTLMA SHPTPYGDLLMQSGGAASAPHLHDYLNPVDASRFSSPRVTPRLSRKRALSISPLSDASLD LQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQR GLGSAFGHTPPLIQPSPTFLAQQPMTLTSISTMPTQLSSSSSNCLNDANQNKQNSESAVS STVNPITIHKRSKVKTEAEGLRPASPLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCH WADCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGE KPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSN EKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHVRAPLLKENGDNEASA EPGGRGPEESVEASSTSHTVEDCLHIKAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNN DSGMEMPGTGPGSLGDLTALADTCPGADTSALAAPSTGGLQLRKHMSTVHRFEQLKREKL KSLKDSCSWAGPAPHTRNTKLPPLPVNGSVLENFNNTGGGGPAGLLPSQRLPELTEVTML SQLQERRDSSTSTMSSAYTVSRRSSGISPYFSSRRSSEASPLGGLRPHNASSADSYDPIS TDASRRSSEASQCSGGGPGLLNLTPAQQYNLRAKYAAATGGPPPTPLPGLDRVSLRTRLA LLDAPERALPGACPHPLGPRRGSDGPTYSHGHGHGYAGAAPAFPHEGPNSSTRRASDPVR RPDPLILPRVQRFHSTHNMNPGSLPPCADRRGLHVQSHPSVDSNLTRNAYSPRPPSINEN VVMEAVAAGVDGPGLECDLGLVEDELVLPDDVVQYIKAHTGGTLDDGIRQGYPTEGTGFP ENSKLPSPGLQGHRRLAAADSNMGPSAPGLGGCQLSYSPSSNLNKSNMPVQWNEVSSGTV DALPTQVKPPPFPHSNLAVVQQKPAFGQYPGYNPQSVQSSSGGLDSTQPHLQLRGAPSAS RGSYTQQPRQPAAGSQCLGMSAAMSPQASYSQAHPQLSPNIVSGSLNQFSPSCSNMAAKP SHLGLPQQMEVVPNATIMNGHQREHGVPNSSLAAVSQPHPVLSYPQQDSYQQGSNLLSSH QPGFMESQQNAGFGLMQPRPPLEPNTASRHRGVRSGQQQLYARTTGQAMVTSANQETAEA MPKGPAGTMVSLAPQPSQDTGRAQDQNTLYYYGQIHMYEQNGGCPAVQPQPPQPQACSDS IQPEPLPSPGVNQVSSTVDSQLLEPPQIDFDAIMDDGDHSSLFSGALSPTLLHNLSQNSS RLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT >Rattus norvegicus_GLI2(ENSRNOP_9963) MTLTSITVPTQLGSNSSNCISDANQNKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPAS PLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIHG EKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLR SHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHV KTVHGPDAHVTKKQRNDVHLRAPLLKENGDNEAGAEPGGRGPEESVEASSTSHTAEDCLH IKAIKTESSGLCQSSPGAQSSCSSEPSPLGSVPNNDSGVEMPGTGPGSLGDLTALDDTSP GADTSALAVPSTGGLQLRKHMTTMHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLP VNGSVLENFNNTGGCGPAGLLPNQRLPELTEVTMLSQLQERRDSSTSTMSSAYTVSRRSS GISPYFSSRRSSEASPLGGIRPHNASSADSYDPISTDASRRSSEASQCSGGGPGLLNLTP AQQYSLRAKYAAATGGPPPTPLPGLDRVSLRTRLALLDAPERALPGACPQPLGPRRGSDG PTYNHGHGYVGAAPALPHEGPNGSTRRASDPVRRPDPLVLPRVQRFHSIHNMNPGPLPPC TDRRGLHLQSHPSVDGSLTRHAYSPRPPSINENVVMEAVAAGVEGAGLESDLGLVEDDLV LPDDVVQYIKAHTGGALDDSTRQVYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMSPSA PGLGGCQLSYSPSSSLNKSNMPVQWNEVSSGTVDALPTQVKPPSFPQSNLVQQKPAFAHY PGYSPQALQSGSGGLDSTQPHLQLRGAPSASRGSYTQQPRLPATGSQCLGVTAAMSPQAN YSQTHHQLSPNVVSGSLNQFAPSCSNMAAKPSHLGLPQQMEVVPNATIISGHQRELGIAS SSLAAVSQPHPVLGYPQQDGYQQVSGLPSSHQPSFMESQQNTGFGLMQPRPPLEPNTASR HRGVRSGQQQQQLYARTAGQAVVTSANQETAEAMPKGTAGTVVSLTPQPSQDTGRSQDQN TLYYYGQIHMYEQNGGCPAMQPQPPQPQGCSDNIQPEPLPSPGVNQVSSTVDSQLLEPPQ IDFDAIMDDGDHSSLFSGALSPSLLHNLSQNSSRLTTPRNSLTLPSIPVGISNMAVGDMS SMLTSLAEENKFLNMMT >Danio rerio_GLI2a(ENSDARP_10693) METTSPTSTEKKELKPSVLDGSSFTDLPKKPSPTTASRAPHLFSTFHTPIPIDMRHHEGR YHYEPHPLHPMHGPHGLAGSPVISDISLIRLSPHAAATGESPFNPPHPYVNPHMEHYLRS VHSSPTLSMISAARGLSPAELTHEHLKERSLFGLPPPPPGANPSEYYHLIASHRSPYGDL LMQTGAAAAHLPDYMSPVDMSRFPSPRLTPRVSRKRALSISPVSDASIDLQTMIRTSPNS LVAYINNSRSSSAASSSYGHLSVGAISPSFTFPHPITPVAYHQLLSQQRGLNAFGHTPPL LQPSPALSSRQQTLVAAAALNNTTSSSTSSSTADTSTESSQNAGGDPAVSSTVNPMIFKR SKVKTEAEGPHPISPGSQDHLELREELDKDECKQEPEAVYETNCHWEGCAKEYDTQDQLV HHISNDHIHGEKKEFVCRWVECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYS RLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRY TDPSSLRKHVKTVHGPEAHVTKKQRGDAPPKPHPPKGNGENEAHTKHVRGRTDGSGEANS TTRGVEDCQHVKTIKTENTVMYQSSPGGQSSCSSEPSPLGSATNNDSGVEMAMHSGGSLG DLSALDDTPVVDSTGSPGTSAGVGLQLRKNRAGLLQLEHIKKEKLKTVRDSCSWANAPPQ VRNTKLPPIPSIDSLLDAPNMGTQMSVPPTQHLGDLSSYEMTMLNQLHERRDSSTSTMSS AYISRRSSGISPCYSSRRSSEASQFGVRNNNVSSADSYDPISTDLSRRSSEASQCGGTGG LPSLLNLTPAQHYSLKAKYAAATGGAPPTPLPNMDRMSLKTRMAMYNDSQDSSAHLHHAQ GVVNSRRCSDTGYGAPGMMPHEVPANLPRRASDPVRRTTLDPLSLPRVQRFNSISNMNLS RLPAYDRRAFNMQNNTWSDGSLHRHPFSQRPPSISENILMENMATDGGDQQGDDLVLPDD MVQYLRSQNGNSNHDSGISVNGGHALEFHGNMTSQQQQFYGQRRMGMAGINGSHVEPVPE QIADPQGMNKNNMPVQWNEVSSGSADAVSRVPKQQQQQLRGNLTVVQQKQNFGSYQGFGS NQQIVPMSQNLASLQQAYPQRNIQRMNTVQQFRQSISNPCQNIGEQVNRQDLSYNSNQRL ICNSMGPPNGRMVQNQELQNYRSNLMHMNNINQQNYVPLTQTAFQNAGRGLIQPRPPSEP KPLNRQHSGSGMVQPNGCSLSNVNSSEASPKRPGEVGQHSNGNGTMYYSGEIHMLDNGID YGSPMSPCTNQAPVASVSTMASPGVNQVTSTVDSTQSLDHTQIDFDAMLDDGDHSSLMSG TLSPGLLQSISQNSSRLTTPRNSVTLASVPAGIGNMAIGDMSSMLTALAEESKFLNMMA >Danio rerio_GLI2b(ENSDARP_15266) MEAGVPAPAEKKDCKSSPLEGNVFSEMPKKPSPSSLSRGPHHIFPTFHSPIPIDVRHHEG RYHYDPHALHALHGPPGLAGSPVISDISLIRLSPGAAGEAFLPPHSYVSPHVEHYLRSAH SSPTLSMISAARGLSPAEVAHEHLKERGLFGLPPPPGASPADYYHLMAGHRNPYGELLMQ GAGAAAAAAHLPEYFTSVDVSRFPSPRMTPRLSRKRALSISPLSDASIDLQTMIRTSPNS LVAYINNSRSSSAASSSYGHLSVGGISPSFPFPHSINPVAYQQLLTQQRGLSAFGHTPPL IQPSPTFSSRHPLSLSTLPTPTTNDTETKNSNGESAVSSTVNPLGNKRSKVKTELGGPRP VSPYSPEHLSSAQDLKEDMDDCKQEAELVYETNCHWEGCSKEYDTQEQLVHHINNEHIHG EKKEFVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLR SHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHV KTVHGPEAHVTKKQRGDLPSRPHPPKENGENEAGAKMAEEKIEANSTTRGVEDYLQVKSI KTENSMMYQSSPGGQSSCSSEPSPLGSASLHGGGVEPAGLSGGSVGDLSALDDVPIVDST VSTGILGLHLRKNAGPAHRLTHLKQEKLKSVRDSCSWANTAPPAPCTKLPPINTGSLLDG LCDPGLSISSPRLGDLCPGETTVLSQLVERRDSLASTVSSAYTFSRRSSGISPCYSSRRS SQTSQPGGRHNNISSADSYDPISTDLSRRSSEASLYGGIFSLTPAQHYRLKAKYAAATGG APPTPLPNIDCKTLLGDSHEIPIHPPLVPRRCSDTGYANRSVLPHEVTANITRRASDPVR RIAAERHSLYNSVNPYPTLHPLASSRHFYSTSESNVNRQQYPPRAPSISENVMMETLPDD MESCNGVEDGLMMADDAVQCITTQNADSPQHTGVAHRNQSFGSPQHCHLQRRLALVEGNM NAVARQTASSQQTFPGSANATKIPMPVQWNEVSSGTVDSSRSQTKQGSGRGNLQQKQNLS SFLNVNSNQQVGLMSHNLALSPVQRSVEFNSLRINQRQANAEFLHGYLQGSASNDISLGL LNPSGKSLTVQPGGVQNNRVCAQAQSHATFPNNQGNYSQMSSNQQGYIVASQNVNGNLLL QPRPPTEPKPYSTQHSGPTTTAAQSNFSPAYDTSEASPKKSSSMFYTGQIHMFDSSGAMP CPSSVGSPETNQVSSTVDSSGADPPQIDFDAMLDDGDHSSLMSGTLSPALLRSLSQNSSR LTTPRNSVTLPPVAAGISNMAIGDMSSMLTALAEESKFLNMMS >Takifugu rubripes_GLI2(ENSTRUP_4513) MENSATTAAEKKECKSSGLDGSPSEIPKKLSPTTLSRGAHHLFPTFHTPIPIDVRHHEGR YHYEPHPLHPMHGPPGLTGSPVISDISLIRLSPHAAPGSGESPFSPPHPYMSPHMEHYLR SVHSSPTLSMISAARGLSPAEVSHEHLKERTLFSLPPPPPGANPTEYYHLMASQRSPYGD LLMQSGEMGPHLFSKPFIGPLSAVSRFSSPRLTPRLSRKRALSISPLSDASIDLQTMIRT SPNSLVAYINNSRSSSAASSSYGHLSVGPGISPSFGFPPHINPVAYQQLLSQQRGLSAFG HTPPLIQPSPSSFSTRQHPLSASAMSAALNNSNSDTRGSFSSVCQSASGDPAVSSTVNPL TTKRSKVKTEAEGLLPISPSSQDHGGGILDLSEDLDKDECKQEPEAVYETNCHWEGCTKE YETQDQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF EGCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCK IPGCTKRYTDPSSLRKHVKTVHGPEAHITKKQRSDVPPRPQPPKGNGVNEANSRHGAKGV EGKIEANSTSGGMEDCLQIKSIKTENSMTYQSSPGGHSSCSSEPSPLGSTNNNDSGVEMA MHSGGSFGDLSAQDECPMVDSTVPAGGQQAVMGLHLRKAVGHPGTVTIKLENIKKERLKT VSTSDWVNSAAQPLQGQRSSVKLPPIPAVGSLLENSTLMSNSSISYPGQRRGDLSSCEVT LLNQLNERRDSTTSTISSAYTISRRSSGISPGYSSRRSSEASQFGANRHNNISSADSYDP ISTDLSRRSSEASQCGGGGLGGGATLPSLLSLTPAQHYRLKAKYAAATGGAPPTPLPNMD RMSLRTRMALYSDSQEASLNQFHQPSPGTVPRRCSDMGYGTRSMMPHEVPGNLPRRASDP VRRPTLDPLSLSRFQRYNSMNNMNPLNVSTAERYQSLVTQGYTRSDGNLQRYPFAPRPPS ISENVAMENMVMDGMTGADQNGEDDLVLPDDMVQYLRSQNTGPSANNLGQVDFHSNHQNH GFQTGMAPPPSYYSQRRMAMVDATMTHSAQDSQQPFSAPPENMNKNNMPVQWNEVSSGTV DSTAKLSKPQHHPLRGNLAVVQQRHNFSSFQGQGQALSSNHQVVPMSQNVSMQYVPVNFG EHMSPQQGFGQEFIPNSISGSTSMRPAQNVVASSELQRGRTQTDGGSLQPRPPAEPKSNM RQHPGSNMMHPNRVAKSSALSPCDGTETSEASPKRRSGPAAHNSSSENSVFYTGQIHMFE PSFDAPMSPCASEPPANSTSAANMASPGVNLVSSSTIDSSTGVSGGPQHPQIDFDTMLDD GDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGNMAIGDMNSMLTALAEE SKFLNMMS >Tetraodon nigroviridis_GLI2(ENSTNIP_20986) MAAPRLDAHPAPRPRGFSTSVSRFSSPRLTPRLSRKRALSISPLSDASIDLQTMIRTSPN SLVAYINNSRSSSAASSSYGHLSVGPGIRNPVGGILDLSEDLDKDECKQEPEAVYETNCH WEGCTKEYETQEQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGE KPHKCTGCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTHSNEV GPQLAAMPCSVHPNSELESPSFQKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKK QRSDMAPRPQPPKGNGVNEANSRHGAKGVEGKLEANSTSGGMENCLQIKSIKTENSMMYQ SSPGGHSSCSSEPSPLGSTNNNDSGVEMAMHSGGSFADLSAQDESPMVDSTVPAGGQQAG VGLHLRKAVGHSGTVTIKLENIKKERLKTVSTSDWVSSAAQPLQGQRSSVKLPPIPAVGS LLENSTMMSNSSVCYPGPRKGDLSSCEVTLLNQLNERRDSTTSTISSAYTVSRRSSGISP GYSSRRSSEASQFGANRHNNVSSADSYDPISTDLSRRSSEASQCGVGGGATLLSLTPAQH YRLKAKYAAATGGAPPTPLPNMDRMSLRTRMALYSDSQEASLHQFHQPPTGAVPRRCSDM GYGTRSMMPHEVPSSLPRRASDPVRRPPLDPLSLPRVQRYNSMNNMNPLNVTTAERYQSL LAQGYTRSDGNLQRYPFAPRPPSISENVAMENMAMDGMAGGDQNGEDDMVLPDDMVQYLR SQNTDPSANNSCQVDYHSNHQNQGFQAGIAPPPAYYSQRRMAMVDASMPHSGQDSQQPFS APPANTNKNNMPVQWNEVSSGTVDSTSKLSKQQHHPLRGNLAVVQQRHNFSSFQGPSQAL SSNQQVVPMSQNVSTQAYANHSNQRLTHASQPQQQQQRQYIPANFGQHMSPQQGFGQEFI PNSISGSTSMRPAQNGMASSEPQSYRARTQTDGYCRVNPMDVQQNYNVLTQQHQSIHSGA RGSLQPRPPAEPRSSLRQHLGSNMMPPNRVPKSSALSPCDGNETSEASPKRCSGLAAQNS NSENSVFYTGQIHMFEPSFDAPMSPCASEPPANSTTAASMASPGVNLVSSSTTDSSTGAS GGAQHPQIDFDTMLDDGDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGN MAIGDMNSMLTALAEESKFLNMMS >Gasterosteus aculeatus_GLI2(ENSGACP_2018) HLFPTFHTPIPIDMRHHEGRYHYEPHPLHAMHGPPGLTGSPVISDISLIRLSPHVAPGTG ESPFSPPHHYVSPHMEHYLRSVHGSPTLSMISAARGLSPAEVTHEHLKERALFNLPPPPP GANPTDYYHLMASASQRSPYGDLLIQSTAHLPEYISPMDVSRFSSPRLTPRLSRKRALSI SPLSDASIDLQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGGISPSFSFPHPINPVA YQQLLSHQRSLNAFGHTPPLIHPSPSSFSARQHPLAASPMTTSHNTSSSEANQCVNTCKN ASGDPAVSSTVNPLSTKRSKVKTEAEGPLPISPSSQDHCGGILDLSEDLDKDECKQEPEA IYVTDCHWEGCSKEYDTQDQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVH MRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKH QNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRSDAPPRPQPPRGD GENGANSKIADGRVEANSTSRGVEDCLQVKSIKTENSMTYQSSPGGHSSCSSEPSPLSSA NNNDSGVEMALHSGGSFGDLSALDDCPMVDSTVSAGGQQAGVGLQLRKAVGHVGTVTIKL ENIKKERLKTVRDSCPWVNSAPQPPQGQRSSMKLPPIPAVGSLLESSNMISNLSGSYPGQ RIGDLSSSEITLLNQLNERRDSTTSTMSSAYTMSRRSSGISPCYSSRRSSEASQFGTNRH NNISSADSYDPISTDLSRRSSEASHCGGGGVGGGGLPSVLSLTPAQHYRLKAKYAAAIGG APPTPLPNMDRMSLRTRMALYGDPQEGTLHPFHQPDFGTVPRRCSDIGYGTRSMMPHEVP TSLPRRASDPVRRPTLDPLSFPRVQRYNSMNSMNPVNGPPAERHQALTMQGYTRSDGSLQ RYPFAPRPPSISENVAMENMAVDGMIIGGEQGGEDDMVLPDDVVQYLRSQNSGPSGHNLG QGDFHSNNLTKGYQTGMTSSASFYAQRRMAMADANMTQSGQDMQSQQPFSAPPGNVNKNN MPVQWNEVSSGTVDTTKKLSKQHQHPLRGNLAVVQPRHNLGSFQGQGQGLGSNQQVVPMS QNMSIQGYANHNSQRMMSIPPQQHQQLRQCNPVNMSEQMSPQQGFGQEIIPNSISGSTSV RPTRNNMAVTEVHSYRARTQVDGYCHVNQVDQQQNYSVVSQQHNIHNGGRGMLQPRPPIE PKAIARQQTGSSMMQPNRIPKSSDLNPSFGTDTSEASPKRPTGSSAHNCNSANPNSAMLY SGQVHMFAPTSVSFDASMPPSASHAPASNTTAADHMASPGVNHVSSSTVDSSTNAAAGTE HAQIDFDTLLDDGDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSVTLTSVPAGIGNMAIG DMNSMLTALAEENKFLNLIS>Homo sapiens GLI1 MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP PNMAVGNMSVLLRSLPGETEFLNSSA >Mus musculus GLI1 MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETS SCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSP GGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQARGPRATC QLKSELDMMVGKCPEDPLEGDMSSPNSTGIQDHLLGMLDGREDLEREEKPEPESVYETDC RWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTG EKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHS NEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKRE REGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDL SSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVS LDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARG SGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFK SLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLN PYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPEN WGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSE GSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLV CNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPA SANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPE VGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTP SPSGPPNMAVGNMSVLLGSLPGETQFLNSSA >Rattus norvegicus GLI1 MFNPMTSPQVNSYGEPCCLRPLPSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGSARETS SCTEGSLFPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS YGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTQGSMMLHPQSRGPRATCQLK SELDIMVGKCPEEPLEGDMSSPNSTSTQDHLLGMLDGREDLEREEKPEPESVYETDCRWD GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEK PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREG GSGREESRLTVPEGTMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSL DEGPCVAATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDR RSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLTPAQHYMLRARYASARGSGT PPTAAHSLDRIGGLPAPPWRSRAEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLG CVHTPPSVATGRNFDPHLPTSVYSPQPPSITENVAMDTRGLQGELEVGTSMMGNDLNPYM DFSSADTLGYGGPEGTAAESYGSKGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPETWGE FPSHAGVYPGTKALGTAYNQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSP DPQPLFSHHSQLPPPQYLQSGPYPQPPHDCLSLESRPGLNFNPSSHSTGQLKAQLLCNYV QSQQELLWEGRSRGGIPNQELPYQSPKFLGGSQVSQSPTKVPAAAAAATFGSGFASPALA NHKSVSYPAPSPCHETFTMGVNRPPHRPAAPPRLLPPLPPCYGPLKVGDANPSCGHPEVG RLGAGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEAQGLSPPPSHEQGDSSKNTPPP SGPPNMAVGNMSVLLGSLPGETQFLNSSA >Tetraodon nigroviridis GLI1 MYNPMTSAIAHGAGTGIGLCTDQYMRPPQALPPHSMMGHRGMPPPEGGNSTPYCNQSNMM PSHHNFCQAQGNSDQIGSGDGSRFSTPRSMLKLSKKRALSISPLSDASVDLQTVIRTSPN SLVAFVNSRGNANGASSYGHLSVGAMSPSLGYTSNISCQSRQQGSLYGGGGVTPLGHTPG PCQGSRLPPHNPRLHAPPKHGHLKTEPGLSSVMDGMNVKSLEERSEGDVASPSSTGTQDP LLGLLDGRDDLDKEDGKPEQEAIYETNCHWESCNKEFDTQDQLVHHINNEHIHGEKKEFV CHWQDCSREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEK PYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGP EAHITKKHRGDTGPRPPGSAMTPGGQSSELLLEKEEARRDDCKLMAPETSLKSQPSPGGQ SSCSSERSPLGSANNNDSGVEMNLNAAGSLEDLTALEDGVGGGGGGGGEPGNVGGTMAMS AQALKRLENLKIDKLKQICRPSPPARCAGSKLPAIPGTGDNMGMCVPPPLLSNRRVMELS SHELGGSASVGCSNDRRGSGTSSLSSAYTVSRRSSMVSPYLSSRRSSEVSQMGGTAGGGC HSFGSEIVADPLSPETNRRGAPCPGGGLPGLSNLTPAQQYNLKAKYAAATGGPPPTPLPN MEQMGATTARRGGYLSEYQGQPLPPFLTQGGPRRHSANTEYGTGVIYPHQAPGNNTRRAS DPLSPGHDSLRCPDQAYMHGRYQNPGGDVSSKAGNSTGQARPFQSEGMSNSLLQQTEYSM STCQLSPSAPHYPSIGQGGDAGGRWSDNHSHIPTPAHELQSQQGLQYTDAQHTHFNSQPG LYNSPGGTHKLVIKPEQQFHVGMGGRDACQSAKLQQQRMLLQQAQGYPQPAGAVMMRNSS SSNCGFQAQNQTTFASGGSVSLGCAGKALSDGQRSETPMMQVKEMMVRNYVQSQQALMWE QQQEQQQQNPTGDSKSVPLSPYAESGPIANALENLDLDNTRIDFTSIIEDAESSSFGPIN NTLEGQPGPSSQASSRLTTPQNSVSLSAESGLSNMAVGDMTSMLTSLAGENKFLNTLS >Gasterosteus aculeatus GLI1 MPVDMQPHQGLYHYETSPSHPSRGLVPSDQSPYTDVSSLRAPLLNGHPQDCRAMYNPMTP SMAHGSGQGIGNCMDQYMRPPQAPPPHSMMGHRGMPPTDGGNSTAYCNQNNMMSSHHNFC QFQSSSDQIGSGDGSRFSTPRSILKLSKKRALSISPLSDASVDLQTVIRTSPNSLVAFVN SRCNPNGASSYGHLSVSAMSPSLGYSSNINCQSRQQVSMYGGGGGTPLGGHSTGPCQASR LPPHNPRLHAPPKHGHLKTEPGLGGVMDGMNVKSLEERSEGDVASPSSTGTQDPLLGLLD GRDDLDKEDGKPEPEAIYETNCHWESCNKEFDTQDQLVHHINNEHIHGEKKEFVCHWQEC SREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEH EGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITK KHRGDTGPRPPGSAMTPGGQSSELLLEKEETRREDCKLLAPETTLKSQPSPGGQSSCSSE RSPLGSANNNDSGVEMNLNAAGSLEDLTALEDGVAGGGEPVGVGTMGMSSQALKRLENLK IDKLKQIRRPTPPGRCSNNRLPALPGPGENMGMCAPSPLLSNRRVMELSNHELGGGAPIG CSSNDRRGSGTSSLSSAYTVSRRSSMVSPHLSSRRSSEVSQMGGTGGGGCHHLSAEKSVG DPLSPETNRRGAPCPGGGLPGLPNLTPAQQYSLKAKYAAATGGPPPTPLPNMEQPGTPAR RGVLSEYQGQPLPPFLQKGGPRRHSANTEYGTGVIYPHQAPGNHSRRASDPVRSVADPQA LPKRFNSLNNVAMMGRRNALHRGSDTSLARHLYSPRPPSITENVMMEAMGMEPHLAPIDA RDRSMMMPPGERSFMGYQQQHQSLGGVGGPLGNQLSPSHDSLSCPDQVYMQGPYQNQGGE VTSRAGGNPMGQVRPIHSEGISNALLQQAEYSMSTCQLSPSGPHYPSIGQGGDAGGPWSD SHGQNQRGLQYSDPSLQPQQTQAHFNNQTGLYSSPDGTHKLTIKPEQQFHPGMGGGNACQ SAKLQQQQRMLVQQPQGYPQQTGQVLMGNSNNPSCDFQGQNQNSFPAAGGLSLGCAGTAL ADGQRSETPMMQVKEMMVRNYVQSQQALMWEQQQEQQQQSGIKPPPLSDNMDMSGQTAIM QHSPQHQNQTLYSSQPYPSYPNQNLAMSPPGHSRGPGSVTPKDQQLAGLQVSCYGQEMVV PRPPQGRKPLSRQNSLSQVGVGYLGSPPHLSPVHSASSPRRVVRLPPVQHPQHQQNEMFS PSNNNMYYSGQISMDMDKHMDPQIGTCLNQPHTMRSNLDPTGGTKTSPMTPYPESGPISN ALEHLDLDNARIDFTSIIDDAESSSFSPINNPLHGLPGSSSQASSRLTTPQTSGLSNMAV GDMTSMLTSLAGENKYLNTLS >Danio rerio GLI1 MPVDMQPHQGLYHYDNTSNQPSRGLAPSVRSPYSSEASSVCVALSGGQSVNSREMYNPSM APGACMEPYMRAPHAPPPHSMMGHRGMPPPEGMSGAPYCNQNMMTSHHNLPHNQHTSELM ASGDASCFSTPRSMLKLSKKRALSISPLSDASVDLQTVIRTSPNSLVAFVNSRCGPNNPS SYGHLSVGTMSPSLGFSSSINYSRPQGNIYSHPVPSCIGAPARLPPHNPRLHTPAKHTHL KTEPVLGSVMDSINIKGLEDHSEGDVASPSSTGTQDPLLGLLEGRDDLDKEEKPEPEAIY ETNCHWESCSKEFDTQEQLVHHINNEHIHGEKKEFVCHWKDCSREQRPFKAQYMLVVHMR RHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQN RTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPEAHITKKHRGDTGPRPPGLTTAGQ SSELLIEKEERNREDCKLLAPDNTLKSQPSPGGQSSCSSERSPLGSANNNDSGVEMNLNA AGSLEDLTTQEDSGNAGVSESSATISSGGMCMSVQALKRLENLKIDKLKQIRRPTPPGRN AGNKLPALSATGEMMSMCAPSPLLSNRRVMELSAPDMGGVTGMSCPPNDRRGSGTSSLSS AYTVSRRSSMVSPYLSSRRSSDVSHCQSVMGGEVPGDPLSPQNSQRAGLCQNSGGLPGLP SLTPAQQYSLKAKYAAATGGPPPTPLPNMDQAGTPARHVGFLRECQGQPLPPFLQQGGTR RHSANAEYGTGVIYPHQAPGNNTRRASDPVRSAADPQGLPKVQRFNSLSNVSLMSRRNAL QQCGSDAALSRHMYSPRPPSITENVMMEAMGMDGNTEGRQQGNMIPGGDRSYMGYQHNPH QASQLSPGQESLGCIDQVYQSQMQGQYQREESCSTGVMGQADIANNLLQQAEYGMSTCQL SPSGPHYPSQGDGSGPWGQTNQLHSPGMQYQGAGMQGQHYTQQGIYDPTSNPNLQRVTVK PEQFHPSMGGSSSCQNTKALHQNRHNANMQTYPLQGQGIMNRSSSASCDFHHSQMGTQPN QGGSFQSGTGINLALAESRRSQTPMHQMKEMMVRNYVQSQQALLWEQQQEQSVSEKPDGM DMGQTQMMQHSPQHQQANQNLYPGNTYQGYPNQNLMSPQQNRVPGSVKEQMQSSCYGPDM IPRPPQVRKSLSRQNSLSQQAGGAYLGSPPHLSPVHSTASPRRGVRLPPVQQQQQQQQQH SENFNNNNNPMYYSGQMHMHHDLEKTPEGPCLAQQHLTSSDPTTKPTSISYPDPAPMSNA LEHLDLENAQIDFTSIIDDQEPSSYSPINAPIGHNQCSSQTSSRLTTPQNSITLPSGLSN MAIGDMSSMLTSLAGENKYLNTLS >Takifugu rubripes GLI1 MPVDMQPHQGLYHYDSSPGQPSRGLVPSDQSPYSDVSSLRAPFLNGLPQDCRTMYNPMAS SMTHGSGPGIGLCTDQYMRPPQALPPHSMMGHRGMPPPEGGNSTPYCTQSNMMPSHHNFC QAQGNSDLIGSGDGSRFSTPRSILKLSKKRALSISPLSDASVDLQTVIRTSPNSLVAFVN SRGNANGASSYGHLSVGAMSPSLGYTGNISCQSRQQGSIYGGGGVTPLGGHTPGPCQGSR LPPHNPRLHAPPKHGHLKTEPGLSGVMDGMNVKSLEERSEGDVASPSSTGTQDPLLGLLD GRDELDKEDGKTEQEAIYETNCHWESCSKEFDTQDQLVHHINNEHIHGEKKEFVCHWQEC SREQRPFKAQYMLVVHMRRHTGEKPHKCTFEGCNKAYSRLENLKTHLRSHTGEKPYVCEH EGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHITK KHRGDMGPRPPGSAMTPGGQSSELLLEKEETRRDDCKLMAPETSLKSQPSPGGQSSCSSE RSPLGSANNNDSGVEMNLNAAGSLEDLTALEDGVGGGGGGESASAGGTMGMSAQALKRLE NLKIDKLKQICRPSPPARCGSNKLPALPGTGENLGMCVPSPLLSNRRVMELSSHELGGSA SAGCSNDRRGSGTSSLSSAYTVSRRSSMVSPYLSSRRSSEVSQMGGTAGGGCHVFGSEQI VADPLSPETNRRGAPCPGAGLPGLSNLTPAQQYNLKAKYAAATGGPPPTPLPNMEQIGTT ARRGGVLSEYQGQPLPPFLTQGGPRRHSANTEYGTGVIYPHQAPGNNTRRASDPVRSAAD PQALPKRFNSLNNVALMGRRNALQHRGSDTSLSRHLYSPRPPSITENVMMEAMSMDTHLT PLDSRDHSMMMPPGERSFIGYQQQHQAHGGGASLSNQLSPSHDSLSCPDQAYMHGCYQNP GGDVTSKDGNSIGQARPHQSEGMTNTLLQQTEYSMSTCQLSPSAPHYPSISQSGNAGGRW GNNHSQIQSSPHELQSQQGMQYTDASLQSQQTHFNNQPGLYNGPGGTHKLVIKPEQQFHP VMGGRDACQSAKLQQQRMLLQQTQGYPQQTGQVMMRNSSNSSCGFPVQNQNTFASGGSVS LGCAGKALSDGQRSETPMMQVKEMMVRSYVQSQQALMWEQRQEQQQQSGIKPALSDNVDL AAQTAMIQHSPQHQNQNLYPNQPYPSYPNQNMIMSPPSRGPSSVPPKDQQLTGLQGSCYG QEMAPRPPQGRKPLSRQNSLSQVGGVYIGSSPHLSPVHSSSPRRGVRLPPVQHPQHPQNE MFSPSNNNNNLYCSGQVNLDKIIDSQNGPCLNQQHGMGSGLDPTSDPKSAPLGPYPESGP ISNALENLDLDNTRIDFTSIIDDAESSSFGPVNSTLQGQPGSSPQASSHLTTPQTSMSLT AGSGLSNMAVGDMTSMLTSLAGENKYLNTLS >GLI2 Homo sapiens METSASATASEKQEAKSGILEAAGFPDPGKKASPLVVAAAAAAAVAAQGVPQHLLPPFHA PLPIDMRHQEGRYHYEPHSVHGVHGPPALSGSPVISDISLIRLSPHPAGPGESPFNAPHP YVNPHMEHYLRSVHSSPTLSMISAARGLSPADVAQEHLKERGLFGLPAPGTTPSDYYHQM TLVAGHPAPYGDLLMQSGGAASAPHLHDYLNPVDVSRFSSPRVTPRLSRKRALSISPLSD ASLDLQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQIL SQQRGLGSAFGHTPPLIQPSPTFLAQQPMALTSINATPTQLSSSSNCLSDTNQNKQSSES AVSSTVNPVAIHKRSKVKTEPEGLRPASPLALTQGQVSGHGSCGCALPLSQEQLADLKED LDRDDCKQEAEVVIYETNCHWEDCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTRE QKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGC NKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQR NDVHLRTPLLKENGDSEAGTEPGGPESTEASSTSQAVEDCLHVRAIKTESSGLCQSSPGA QSSCSSEPSPLGSAPNNDSGVEMPGTGPGSLGDLTALDDTPPGADTSALAAPSAGGLQLR KHMTTMHRFEQLKKEKLKSLKDSCSWAGPTPHTRNTKLPPLPGSGSILENFSGSGGGGPA GLLPNPRLSELSASEVTMLSQLQERRDSSTSTVSSAYTVSRRSSGISPYFSSRRSSEASP LGAGRPHNASSADSYDPISTDASRRSSEASQCSGGSGLLNLTPAQQYSLRAKYAAATGGP PPTPLPGLERMSLRTRLALLDAPERTLPAGCPRPLGPRRGSDGPTYGHGHAGAAPAFPHE APGGGARRASDPVRRPDALSLPRVQRFHSTHNVNPGPLPPCADRRGLRLQSHPSTDGGLA RGAYSPRPPSISENVAMEAVAAGVDGAGPEADLGLPEDDLVLPDDVVQYIKAHASGALDE GTGQVYPTESTGFSDNPRLPSPGLHGQRRMVAADSNVGPSAPMLGGCQLGFGAPSSLNKN NMPVQWNEVSSGTVDALASQVKPPPFPQGNLAVVQQKPAFGQYPGYSPQGLQASPGGLDS TQPHLQPRSGAPSQGIPRVNYMQQLRQPVAGSQCPGMTTTMSPHACYGQVHPQLSPSTIS GALNQFPQSCSNMPAKPGHLGHPQQTEVAPDPTTMGNRHRELGVPDSALAGVPPPHPVQS YPQQSHHLAASMSQEGYHQVPSLLPARQPGFMEPQTGPMGVATAGFGLVQPRPPLEPSPT GRHRGVRAVQQQLAYARATGHAMAAMPSSQETAEAVPKGAMGNMGSVPPQPPPQDAGGAP DHSMLYYYGQIHMYEQDGGLENLGSCQVMRSQPPQPQACQDSIQPQPLPSPGVNQVSSTV DSQLLEAPQIDFDAIMDDGDHSSLFSGALSPSLLHSLSQNSSRLTTPRNSLTLPSIPAGI SNMAVGDMSSMLTSLAEESKFLNMMT >Mus musculus GLI2 METSAPAPALEKKEAKSGLLEDSSFPDPGKKACPLAVAAAVAAHGVPQQLLPAFHAPLPI DMRHQEGRYHYDPHSVHSVHGPPTLSGSPVISDISLIRLSPHPAGPGESPFSAHHPYVNP HMEHYLRSVHSSPTLSMISAARGLSPADVAHEHLKERGLFSLAAPGTNPSDYYHQMTLMA SHPTPYGDLLMQSGGAASAPHLHDYLNPVDASRFSSPRVTPRLSRKRALSISPLSDASLD LQRMIRTSPNSLVAYINNSRSSSAASGSYGHLSAGALSPAFTFPHPINPVAYQQILSQQR GLGSAFGHTPPLIQPSPTFLAQQPMTLTSISTMPTQLSSSSSNCLNDANQNKQNSESAVS STVNPITIHKRSKVKTEAEGLRPASPLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCH WADCTKEYDTQEQLVHHINNEHIHGEKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGE KPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSN EKPYICKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRNDVHVRAPLLKENGDNEASA EPGGRGPEESVEASSTSHTVEDCLHIKAIKTESSGLCQSSPGAQSSCSSEPSPLGSAPNN DSGMEMPGTGPGSLGDLTALADTCPGADTSALAAPSTGGLQLRKHMSTVHRFEQLKREKL KSLKDSCSWAGPAPHTRNTKLPPLPVNGSVLENFNNTGGGGPAGLLPSQRLPELTEVTML SQLQERRDSSTSTMSSAYTVSRRSSGISPYFSSRRSSEASPLGGLRPHNASSADSYDPIS TDASRRSSEASQCSGGGPGLLNLTPAQQYNLRAKYAAATGGPPPTPLPGLDRVSLRTRLA LLDAPERALPGACPHPLGPRRGSDGPTYSHGHGHGYAGAAPAFPHEGPNSSTRRASDPVR RPDPLILPRVQRFHSTHNMNPGSLPPCADRRGLHVQSHPSVDSNLTRNAYSPRPPSINEN VVMEAVAAGVDGPGLECDLGLVEDELVLPDDVVQYIKAHTGGTLDDGIRQGYPTEGTGFP ENSKLPSPGLQGHRRLAAADSNMGPSAPGLGGCQLSYSPSSNLNKSNMPVQWNEVSSGTV DALPTQVKPPPFPHSNLAVVQQKPAFGQYPGYNPQSVQSSSGGLDSTQPHLQLRGAPSAS RGSYTQQPRQPAAGSQCLGMSAAMSPQASYSQAHPQLSPNIVSGSLNQFSPSCSNMAAKP SHLGLPQQMEVVPNATIMNGHQREHGVPNSSLAAVSQPHPVLSYPQQDSYQQGSNLLSSH QPGFMESQQNAGFGLMQPRPPLEPNTASRHRGVRSGQQQLYARTTGQAMVTSANQETAEA MPKGPAGTMVSLAPQPSQDTGRAQDQNTLYYYGQIHMYEQNGGCPAVQPQPPQPQACSDS IQPEPLPSPGVNQVSSTVDSQLLEPPQIDFDAIMDDGDHSSLFSGALSPTLLHNLSQNSS RLTTPRNSLTLPSIPAGISNMAVGDMSSMLTSLAEESKFLNMMT >Rattus norvegicus GLI2 MTLTSITVPTQLGSNSSNCISDANQNKQNSESAVSSTVNPITIHKRSKVKTEAEGLRPAS PLGLTQEQLADLKEDLDRDDCKQEAEVVIYETNCHWADCTKEYDTQEQLVHHINNEHIHG EKKEFVCRWQACTREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLR SHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYICKIPGCTKRYTDPSSLRKHV KTVHGPDAHVTKKQRNDVHLRAPLLKENGDNEAGAEPGGRGPEESVEASSTSHTAEDCLH IKAIKTESSGLCQSSPGAQSSCSSEPSPLGSVPNNDSGVEMPGTGPGSLGDLTALDDTSP GADTSALAVPSTGGLQLRKHMTTMHRFEQLKREKLKSLKDSCSWAGPAPHTRNTKLPPLP VNGSVLENFNNTGGCGPAGLLPNQRLPELTEVTMLSQLQERRDSSTSTMSSAYTVSRRSS GISPYFSSRRSSEASPLGGIRPHNASSADSYDPISTDASRRSSEASQCSGGGPGLLNLTP AQQYSLRAKYAAATGGPPPTPLPGLDRVSLRTRLALLDAPERALPGACPQPLGPRRGSDG PTYNHGHGYVGAAPALPHEGPNGSTRRASDPVRRPDPLVLPRVQRFHSIHNMNPGPLPPC TDRRGLHLQSHPSVDGSLTRHAYSPRPPSINENVVMEAVAAGVEGAGLESDLGLVEDDLV LPDDVVQYIKAHTGGALDDSTRQVYPTEGTGFPENSKLPSPGLQGHRRLAAADSNMSPSA PGLGGCQLSYSPSSSLNKSNMPVQWNEVSSGTVDALPTQVKPPSFPQSNLVQQKPAFAHY PGYSPQALQSGSGGLDSTQPHLQLRGAPSASRGSYTQQPRLPATGSQCLGVTAAMSPQAN YSQTHHQLSPNVVSGSLNQFAPSCSNMAAKPSHLGLPQQMEVVPNATIISGHQRELGIAS SSLAAVSQPHPVLGYPQQDGYQQVSGLPSSHQPSFMESQQNTGFGLMQPRPPLEPNTASR HRGVRSGQQQQQLYARTAGQAVVTSANQETAEAMPKGTAGTVVSLTPQPSQDTGRSQDQN TLYYYGQIHMYEQNGGCPAMQPQPPQPQGCSDNIQPEPLPSPGVNQVSSTVDSQLLEPPQ IDFDAIMDDGDHSSLFSGALSPSLLHNLSQNSSRLTTPRNSLTLPSIPVGISNMAVGDMS SMLTSLAEENKFLNMMT >Tetraodon nigroviridis GLI2 MAAPRLDAHPAPRPRGFSTSVSRFSSPRLTPRLSRKRALSISPLSDASIDLQTMIRTSPN SLVAYINNSRSSSAASSSYGHLSVGPGIRNPVGGILDLSEDLDKDECKQEPEAVYETNCH WEGCTKEYETQEQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGE KPHKCTGCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTHSNEV GPQLAAMPCSVHPNSELESPSFQKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKK QRSDMAPRPQPPKGNGVNEANSRHGAKGVEGKLEANSTSGGMENCLQIKSIKTENSMMYQ SSPGGHSSCSSEPSPLGSTNNNDSGVEMAMHSGGSFADLSAQDESPMVDSTVPAGGQQAG VGLHLRKAVGHSGTVTIKLENIKKERLKTVSTSDWVSSAAQPLQGQRSSVKLPPIPAVGS LLENSTMMSNSSVCYPGPRKGDLSSCEVTLLNQLNERRDSTTSTISSAYTVSRRSSGISP GYSSRRSSEASQFGANRHNNVSSADSYDPISTDLSRRSSEASQCGVGGGATLLSLTPAQH YRLKAKYAAATGGAPPTPLPNMDRMSLRTRMALYSDSQEASLHQFHQPPTGAVPRRCSDM GYGTRSMMPHEVPSSLPRRASDPVRRPPLDPLSLPRVQRYNSMNNMNPLNVTTAERYQSL LAQGYTRSDGNLQRYPFAPRPPSISENVAMENMAMDGMAGGDQNGEDDMVLPDDMVQYLR SQNTDPSANNSCQVDYHSNHQNQGFQAGIAPPPAYYSQRRMAMVDASMPHSGQDSQQPFS APPANTNKNNMPVQWNEVSSGTVDSTSKLSKQQHHPLRGNLAVVQQRHNFSSFQGPSQAL SSNQQVVPMSQNVSTQAYANHSNQRLTHASQPQQQQQRQYIPANFGQHMSPQQGFGQEFI PNSISGSTSMRPAQNGMASSEPQSYRARTQTDGYCRVNPMDVQQNYNVLTQQHQSIHSGA RGSLQPRPPAEPRSSLRQHLGSNMMPPNRVPKSSALSPCDGNETSEASPKRCSGLAAQNS NSENSVFYTGQIHMFEPSFDAPMSPCASEPPANSTTAASMASPGVNLVSSSTTDSSTGAS GGAQHPQIDFDTMLDDGDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGN MAIGDMNSMLTALAEESKFLNMMS >Gasterosteus aculeatus GLI2 HLFPTFHTPIPIDMRHHEGRYHYEPHPLHAMHGPPGLTGSPVISDISLIRLSPHVAPGTG ESPFSPPHHYVSPHMEHYLRSVHGSPTLSMISAARGLSPAEVTHEHLKERALFNLPPPPP GANPTDYYHLMASASQRSPYGDLLIQSTAHLPEYISPMDVSRFSSPRLTPRLSRKRALSI SPLSDASIDLQTMIRTSPNSLVAYINNSRSSSAASSSYGHLSVGGISPSFSFPHPINPVA YQQLLSHQRSLNAFGHTPPLIHPSPSSFSARQHPLAASPMTTSHNTSSSEANQCVNTCKN ASGDPAVSSTVNPLSTKRSKVKTEAEGPLPISPSSQDHCGGILDLSEDLDKDECKQEPEA IYVTDCHWEGCSKEYDTQDQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVH MRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKH QNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRSDAPPRPQPPRGD GENGANSKIADGRVEANSTSRGVEDCLQVKSIKTENSMTYQSSPGGHSSCSSEPSPLSSA NNNDSGVEMALHSGGSFGDLSALDDCPMVDSTVSAGGQQAGVGLQLRKAVGHVGTVTIKL ENIKKERLKTVRDSCPWVNSAPQPPQGQRSSMKLPPIPAVGSLLESSNMISNLSGSYPGQ RIGDLSSSEITLLNQLNERRDSTTSTMSSAYTMSRRSSGISPCYSSRRSSEASQFGTNRH NNISSADSYDPISTDLSRRSSEASHCGGGGVGGGGLPSVLSLTPAQHYRLKAKYAAAIGG APPTPLPNMDRMSLRTRMALYGDPQEGTLHPFHQPDFGTVPRRCSDIGYGTRSMMPHEVP TSLPRRASDPVRRPTLDPLSFPRVQRYNSMNSMNPVNGPPAERHQALTMQGYTRSDGSLQ RYPFAPRPPSISENVAMENMAVDGMIIGGEQGGEDDMVLPDDVVQYLRSQNSGPSGHNLG QGDFHSNNLTKGYQTGMTSSASFYAQRRMAMADANMTQSGQDMQSQQPFSAPPGNVNKNN MPVQWNEVSSGTVDTTKKLSKQHQHPLRGNLAVVQPRHNLGSFQGQGQGLGSNQQVVPMS QNMSIQGYANHNSQRMMSIPPQQHQQLRQCNPVNMSEQMSPQQGFGQEIIPNSISGSTSV RPTRNNMAVTEVHSYRARTQVDGYCHVNQVDQQQNYSVVSQQHNIHNGGRGMLQPRPPIE PKAIARQQTGSSMMQPNRIPKSSDLNPSFGTDTSEASPKRPTGSSAHNCNSANPNSAMLY SGQVHMFAPTSVSFDASMPPSASHAPASNTTAADHMASPGVNHVSSSTVDSSTNAAAGTE HAQIDFDTLLDDGDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSVTLTSVPAGIGNMAIG DMNSMLTALAEENKFLNLIS >Danio rerio GLI2b MEAGVPAPAEKKDCKSSPLEGNVFSEMPKKPSPSSLSRGPHHIFPTFHSPIPIDVRHHEG RYHYDPHALHALHGPPGLAGSPVISDISLIRLSPGAAGEAFLPPHSYVSPHVEHYLRSAH SSPTLSMISAARGLSPAEVAHEHLKERGLFGLPPPPGASPADYYHLMAGHRNPYGELLMQ GAGAAAAAAHLPEYFTSVDVSRFPSPRMTPRLSRKRALSISPLSDASIDLQTMIRTSPNS LVAYINNSRSSSAASSSYGHLSVGGISPSFPFPHSINPVAYQQLLTQQRGLSAFGHTPPL IQPSPTFSSRHPLSLSTLPTPTTNDTETKNSNGESAVSSTVNPLGNKRSKVKTELGGPRP VSPYSPEHLSSAQDLKEDMDDCKQEAELVYETNCHWEGCSKEYDTQEQLVHHINNEHIHG EKKEFVCRWDECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLR SHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHV KTVHGPEAHVTKKQRGDLPSRPHPPKENGENEAGAKMAEEKIEANSTTRGVEDYLQVKSI KTENSMMYQSSPGGQSSCSSEPSPLGSASLHGGGVEPAGLSGGSVGDLSALDDVPIVDST VSTGILGLHLRKNAGPAHRLTHLKQEKLKSVRDSCSWANTAPPAPCTKLPPINTGSLLDG LCDPGLSISSPRLGDLCPGETTVLSQLVERRDSLASTVSSAYTFSRRSSGISPCYSSRRS SQTSQPGGRHNNISSADSYDPISTDLSRRSSEASLYGGIFSLTPAQHYRLKAKYAAATGG APPTPLPNIDCKTLLGDSHEIPIHPPLVPRRCSDTGYANRSVLPHEVTANITRRASDPVR RIAAERHSLYNSVNPYPTLHPLASSRHFYSTSESNVNRQQYPPRAPSISENVMMETLPDD MESCNGVEDGLMMADDAVQCITTQNADSPQHTGVAHRNQSFGSPQHCHLQRRLALVEGNM NAVARQTASSQQTFPGSANATKIPMPVQWNEVSSGTVDSSRSQTKQGSGRGNLQQKQNLS SFLNVNSNQQVGLMSHNLALSPVQRSVEFNSLRINQRQANAEFLHGYLQGSASNDISLGL LNPSGKSLTVQPGGVQNNRVCAQAQSHATFPNNQGNYSQMSSNQQGYIVASQNVNGNLLL QPRPPTEPKPYSTQHSGPTTTAAQSNFSPAYDTSEASPKKSSSMFYTGQIHMFDSSGAMP CPSSVGSPETNQVSSTVDSSGADPPQIDFDAMLDDGDHSSLMSGTLSPALLRSLSQNSSR LTTPRNSVTLPPVAAGISNMAIGDMSSMLTALAEESKFLNMMS >Danio rerio GLI2a METTSPTSTEKKELKPSVLDGSSFTDLPKKPSPTTASRAPHLFSTFHTPIPIDMRHHEGR YHYEPHPLHPMHGPHGLAGSPVISDISLIRLSPHAAATGESPFNPPHPYVNPHMEHYLRS VHSSPTLSMISAARGLSPAELTHEHLKERSLFGLPPPPPGANPSEYYHLIASHRSPYGDL LMQTGAAAAHLPDYMSPVDMSRFPSPRLTPRVSRKRALSISPVSDASIDLQTMIRTSPNS LVAYINNSRSSSAASSSYGHLSVGAISPSFTFPHPITPVAYHQLLSQQRGLNAFGHTPPL LQPSPALSSRQQTLVAAAALNNTTSSSTSSSTADTSTESSQNAGGDPAVSSTVNPMIFKR SKVKTEAEGPHPISPGSQDHLELREELDKDECKQEPEAVYETNCHWEGCAKEYDTQDQLV HHISNDHIHGEKKEFVCRWVECSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCSKAYS RLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRY TDPSSLRKHVKTVHGPEAHVTKKQRGDAPPKPHPPKGNGENEAHTKHVRGRTDGSGEANS TTRGVEDCQHVKTIKTENTVMYQSSPGGQSSCSSEPSPLGSATNNDSGVEMAMHSGGSLG DLSALDDTPVVDSTGSPGTSAGVGLQLRKNRAGLLQLEHIKKEKLKTVRDSCSWANAPPQ VRNTKLPPIPSIDSLLDAPNMGTQMSVPPTQHLGDLSSYEMTMLNQLHERRDSSTSTMSS AYISRRSSGISPCYSSRRSSEASQFGVRNNNVSSADSYDPISTDLSRRSSEASQCGGTGG LPSLLNLTPAQHYSLKAKYAAATGGAPPTPLPNMDRMSLKTRMAMYNDSQDSSAHLHHAQ GVVNSRRCSDTGYGAPGMMPHEVPANLPRRASDPVRRTTLDPLSLPRVQRFNSISNMNLS RLPAYDRRAFNMQNNTWSDGSLHRHPFSQRPPSISENILMENMATDGGDQQGDDLVLPDD MVQYLRSQNGNSNHDSGISVNGGHALEFHGNMTSQQQQFYGQRRMGMAGINGSHVEPVPE QIADPQGMNKNNMPVQWNEVSSGSADAVSRVPKQQQQQLRGNLTVVQQKQNFGSYQGFGS NQQIVPMSQNLASLQQAYPQRNIQRMNTVQQFRQSISNPCQNIGEQVNRQDLSYNSNQRL ICNSMGPPNGRMVQNQELQNYRSNLMHMNNINQQNYVPLTQTAFQNAGRGLIQPRPPSEP KPLNRQHSGSGMVQPNGCSLSNVNSSEASPKRPGEVGQHSNGNGTMYYSGEIHMLDNGID YGSPMSPCTNQAPVASVSTMASPGVNQVTSTVDSTQSLDHTQIDFDAMLDDGDHSSLMSG TLSPGLLQSISQNSSRLTTPRNSVTLASVPAGIGNMAIGDMSSMLTALAEESKFLNMMA >Takifugu rubripes GLI2 MENSATTAAEKKECKSSGLDGSPSEIPKKLSPTTLSRGAHHLFPTFHTPIPIDVRHHEGR YHYEPHPLHPMHGPPGLTGSPVISDISLIRLSPHAAPGSGESPFSPPHPYMSPHMEHYLR SVHSSPTLSMISAARGLSPAEVSHEHLKERTLFSLPPPPPGANPTEYYHLMASQRSPYGD LLMQSGEMGPHLFSKPFIGPLSAVSRFSSPRLTPRLSRKRALSISPLSDASIDLQTMIRT SPNSLVAYINNSRSSSAASSSYGHLSVGPGISPSFGFPPHINPVAYQQLLSQQRGLSAFG HTPPLIQPSPSSFSTRQHPLSASAMSAALNNSNSDTRGSFSSVCQSASGDPAVSSTVNPL TTKRSKVKTEAEGLLPISPSSQDHGGGILDLSEDLDKDECKQEPEAVYETNCHWEGCTKE YETQDQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRHTGEKPHKCTF EGCSKAYSRLENLKTHLRSHTGEKPYLCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCK IPGCTKRYTDPSSLRKHVKTVHGPEAHITKKQRSDVPPRPQPPKGNGVNEANSRHGAKGV EGKIEANSTSGGMEDCLQIKSIKTENSMTYQSSPGGHSSCSSEPSPLGSTNNNDSGVEMA MHSGGSFGDLSAQDECPMVDSTVPAGGQQAVMGLHLRKAVGHPGTVTIKLENIKKERLKT VSTSDWVNSAAQPLQGQRSSVKLPPIPAVGSLLENSTLMSNSSISYPGQRRGDLSSCEVT LLNQLNERRDSTTSTISSAYTISRRSSGISPGYSSRRSSEASQFGANRHNNISSADSYDP ISTDLSRRSSEASQCGGGGLGGGATLPSLLSLTPAQHYRLKAKYAAATGGAPPTPLPNMD RMSLRTRMALYSDSQEASLNQFHQPSPGTVPRRCSDMGYGTRSMMPHEVPGNLPRRASDP VRRPTLDPLSLSRFQRYNSMNNMNPLNVSTAERYQSLVTQGYTRSDGNLQRYPFAPRPPS ISENVAMENMVMDGMTGADQNGEDDLVLPDDMVQYLRSQNTGPSANNLGQVDFHSNHQNH GFQTGMAPPPSYYSQRRMAMVDATMTHSAQDSQQPFSAPPENMNKNNMPVQWNEVSSGTV DSTAKLSKPQHHPLRGNLAVVQQRHNFSSFQGQGQALSSNHQVVPMSQNVSMQYVPVNFG EHMSPQQGFGQEFIPNSISGSTSMRPAQNVVASSELQRGRTQTDGGSLQPRPPAEPKSNM RQHPGSNMMHPNRVAKSSALSPCDGTETSEASPKRRSGPAAHNSSSENSVFYTGQIHMFE PSFDAPMSPCASEPPANSTSAANMASPGVNLVSSSTIDSSTGVSGGPQHPQIDFDTMLDD GDHSSLMSGTLSPGLLQSLSQSSSRLTTPRNSLPLASVPAGIGNMAIGDMNSMLTALAEE SKFLNMMS >Homo sapiens GLI3 MEAQSHSSTTTEKKKVENSIVKCSTRTDVSEKAVASSTTSNEDESPGQTYHRERRNAITM QPQNVQGLSKVSEEPSTSSDERASLIKKEIHGSLPHVAEPSVPYRGTVFAMDPRNGYMEP HYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHMTSALSSSPTYPDLPFIRISPHR NPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISATRGLSPTDAPHAGVSPAEYYHQ MALLTGQRSPYADIIPSAATAGTGAIHMEYLHAMDSTRFSSPRLSARPSRKRTLSISPLS DHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYSSAPVSLHMH QQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQNKPTSE SAVSSTGDPMHNKRSKIKPDEDLPSPGARGQQEQPEGTTLVKEEGDKDESKQEPEVIYET NCHWEGCAREFDTQEQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT HSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDIHPRPPPPRDSGSHS QSRSPGRPTQGALGEQQDLSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPI SNYSNSGLELPLTDGGSIGDLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHVKL ERLKQVNGMFPRLNPILPPKAPAVSPLIGNGTQSNNTCSLGGPMTLLPGRSDLSGVDVTM LNMLNRRDSSASTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIST DASRRSSEASQSDGLPSLLSLTPAQQYRLKAKYAAATGGPPPTPLPNMERMSLKTRLALL GDALEPGVALPPVHAPRRCSDGGAHGYGRRHLQPHDAPGHGVRRASDPVRTGSEGLALPR VPRFSSLSSCNPPAMATSAEKRSLVLQNYTRPEGGQSRNFHSSPCPPSITENVTLESLTM DADANLNDEDFLPDDVVQYLNSQNQAGYEQHFPSALPDDSKVPHGPGDFDAPGLPDSHAG QQFHALEQPCPEGSKTDLPIQWNEVSSGSADLSSSKLKCGPRPAVPQTRAFGFCNGMVVH PQNPLRSGPAGGYQTLGENSNPYGGPEHLMLHNSPGSGTSGNAFHEQPCKAPQYGNCLNR QPVAPGALDGACGAGIQASKLKSTPMQGSGGQLNFGLPVAPNESAGSMVNGMQNQDPVGQ GYLAHQLLGDSMQHPGAGRPGQQMLGQISATSHINIYQGPESCLPGAHGMGSQPSSLAVV RGYQPCASFGGSRRQAMPRDSLALQSGQLSDTSQTCRVNGIKMEMKGQPHPLCSNLQNYS GQFYDQTVGFSQQDTKAGSFSISDASCLLQGTSAKNSELLSPGANQVTSTVDSLDSHDLE GVQIDFDAIIDDGDHSSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPAVHEHHQHGYRG HEFFADLPSGRKQIPCSYAIGFRKKRLQPTEINRS >Mus musculus GLI3 MEAQAHSSTATERKKAENSIGKCPTRTDVSEKAVASSTTSNEDESPGQIYHRERRNAITM QPQSVQGLNKISEEPSTSSDERASLIKKEIHGSLPHLAEPSLPYRGTVFAMDPRNGYMEP HYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPSALSSSPTYPDLPFIRISPHR NPTAASESPFSPPHPYINPYMDYIRSLHCSPSLSMISAARGLSPTDAPHAGVSPAEYYHQ MALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDSTRFPSPRLSARPSRKRTLSISPLS DHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSYGHLSASAISPALSFTYPSAPVSLHMH QQILSRQQSLGSAFGHSPPLIHPAPTFPTQRPIPGIPTVLNPVQVSSGPSESSQSKPTSE SAVSSTGGPMHNKRSKIKPDEDLPSPGSRGQQEQPEGTTLVKEEADKDESKQEPEVIYET NCHWEGCTREFDTQDQLVHHINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRH TGEKPHKCTFEGCTKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT HSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHS QSRSPGRPTQGAFGEQKELSNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPI SNYSNSGLELPLTDGGSVADLSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHIKL ERLKQVNGMFPRLNPILPSKAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFTV LNTLNRRDSNTSTISSAYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPIST DASRRSSEASQGDGLPSLLSLTPVQQYALKAKYAAPTGGPPPTPLPHMERLSLKTKMALL GEGRDSGVTLPPVHPPRRCSDGGGHTYRGRHLMPHDALANSVRRDSDPVRTVSENMSLAR VQRFSSLNSFNPPNLPPSVEKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALEALTM DADANLNDEDLLPDDVVQYLNSQNQTGYGQQLQSGISEDSKVAHEPEDLDLAGLPDSHVG QEYPALEQPCSEGSKTDLPIQWNEVSSGTSDLSSSKLKCGQQRPRQQPRGFGLYNNMVVH PHNLWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYGSQL NRQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDFSLSVAPNELAGNTVNGMQTQDQM GQGYIAHQLLSGSMQHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDNSSQPSSMA AIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLCSTVQN YSGQFYDQTMGFSQQDRKAGSFSLSDANCLLQGTCTENSELLSPGANQVTSTVDSFESHD LEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPIPIHGHHQHG YRGYEFFADLPCRRKQVPCSYAVGGRQGGPQTQRLK >Rattus norvegicus GLI3 HINNDHIHGEKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSR LENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYT DPSSLRKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKEL SNTTSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSIA DLSAIDETPIMDSTISTATTALALQGRRNPAGTKWMEHIKLERLKQVNGMFPRLNPILPS KAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFTVLNTLNRRDSNTSTISSAYL SSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQGDGLPSLL SLTPVQQYRLKAKYAAATGGPPPTPLPHMEKLSLKTRMALLGEGRDSGVTLPPVHPPRRC SDGGGHTYSRRHLLPHDALANSARRASDPVRTVSENMSLPRVQRFSSLNSFNPPNLPPSV EKRSLVLQNYTRQESTHPRYFQASPCPPSITENVALEALTMDADASLNDEDFLPDDVVQY LNSQNQTGYGQQLQSSISEDGKVAREPEDLDLPGLPDSHVGQQYPALEQPCSEGSKTDLP IQWNEVSSGSSDLSSSKLKCGQRPTVQQARGFGLYSNMVVHPQNLWKVGTGPAGGSQTLG ENGSSYSDPEHFAVHSGDGLGPSGDTFHEQAYKTQQYGSQLSRQPLTSSVLDSACGAGIQ GSKLKGNSLQENGGLLDFGLSMAPNELADNIVNGIQTQEQMGQGYIAPQLLSGSMQHQGP SRPGQQVLGQVGATSHINIYQGTESCLPGTQDKISQPSSMAVIRGYQPCASYGGSRRQAM PRGSLTLQQGQLSDVSQTSRVNSIKMEAHGQSHQLCSSMQNYSGQFYDQTMGFSQQDRKA GSFSLSEANCLLQENGSENSELLSPGVNQVTSTVDSFESHDLEGVQIDFDAIIDDGDHTS LMSGALSPSIIQNLSHSSSRLTTPRASLPFPSLSMSTTNMAIGDMSSLLTSLAEESKFLA VMQ >Gasterosteus aculeatus GLI3 PGLAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYINPYMDYIRSLHSSPSISVLSA TRGLSPADVISSSFLQKRLLYSAPHTGLTTAEYYHQMALLAGHRSPYATDLLPSVASTAG ATSATALHMEYLQAMENSRFSSPRLPSRPSRKRPLPISPLSDHSFDLQTRIRHSPNSLVT MLNNSRSSSSTSGSYGHLSAGAISPALSFAYPSTPVALHMHQQLLGRQPGMVGSAFGHSP PLIHPSPAYATQRPVPGIPPSGLSASERSALSSDSAQTKPTSESAVSSTGDPMHHKRSKM KPEEELPSPGAVSVQSLGRRGGNCFCFCLIKIDHPDGMTLVKEEGDKDESKQEPEVVYET NCHWENCCREFDTQEQLVQHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLVVHMRRH TGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRT HSNEKPYVCKIQGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDLPLGGYTDQREYNHA TSKQDECLQVKSIKTEKPMTSQPSPGGQSTCSSDQSPVSHYPCSGVQLAVSAGRSLGEGH CVGERAPIMDSTVSTATAAMLTLQARRSVGRPLRWMEHMKMERLKQVNGALPRLGPLSPT PPPKGSTLPNILGKENSNITTDLCLNPAVRNKLSPDSIFPVWLLERSGVKTDVVWVLISS YCVKLNSSGISPCFSSRRSSQASQSEGTAAAAHHHRRLHNLSSSDSYDPISTDASRRSSE ASHGSRGMLTLTPAQHYHLKAKYAAATGGPPPTPLPNMERMSLKTRMAMMDEGGSNQSLP PLVRPHCCGDGANGYANGYAGHAGHRRRVLYPGEGPLNGNRRASDPVRTQAGDMGSLPPV QRFNSLNNLHPLPPLSHHSTPEARSFSLQSYTRSEGNLQRGLQHSPYTPSIAEHAALEAL AMEDEAGLLLGDEDMLPDDLVQYLHSQAQVDGGSYMHIEEQIASSQRDASHPPMEEMGQI QAAGLDMGHAGSHGLLQQQQQTAERTSPSKLPIQWNEVSSGSADRSPQREQIHRAQCGRW PAAEHGPVPFGRFGNMVVQQQVPLDFQNSCVQANQSQGACFVNPAVKLETPPNSCMEMRG FGRPNFAQIIDGPLQQGFKHPPPGGPPKQSHFQQNHSQMGSNLILSRSSVDILPSVSQGA AAHHNRQIHVPRPPDGYRNSARIQQYLNAETSGESQAGLNKQQQLQRSGDHCSLAHQVSG LKLEASDHGYLEQGFGDCLSYAPLDCKASPFPVLEDQCLLNSMVESAGQVVGGGGGGGNS AALLSPGTDQVTSTMEGAVPGILDDGVGLDFGAMLEDGYDQGSLVSGVLSPSIFQGLSRT SSRLTTPRASAAFHSVAPGLNNMAIGDMSSLLTTLAEESKFLAILQ >Tetraodon nigroviridis GLI3 EDDSSGTPFHRERRNAISSHAPTPGGLDRSISEEPSTSTEERPSLLKKELHGSLAHLGDH ALPYRGTLFAMDPRNGYLDSHYLRATLRCRQPVSAGGFLVCLLPKWHPHRYVSAAPQFFP TFHPPVPIDDRHTQGRYIYEPSPVPPLHVFWYPASHRERIRPLSAPRDEGHFFILLSNCP KRIRWNFGGRRPPALAGSPAFSDISLIRISPQRNPSVGAESPFHPPHPYISPYMDYIRSL HSSPSISVLSATRGLSPADAPHTGLTTAEYYHQMALLAGHRSPYAADLLPSLAATAGASG AAASHVEYLHAMESSRFSSPRLPSRPSRKRPLPISPLSEPSFDLQTMIRNSPNSLVNILN NSRSSSSTSGSYGHLSAGAISPALSFAYPPTPVALHVHQQLMGRQPSIVGSAFGHSPPLI HPSPAFTTQRPVPGIPASGISASERSAISSDSSQTKPTSESAVSSTGDPMHHKRSKMKPE EELPSPGAVSIQDHPDGMTLVKEEGDKDENKQEPEVVYETNCHWENCCREFDTQEQLVQV RHKRQVQRRLVGDVGGAALSLFSDEELALHAEAAAHINNDHIHGEKKEFVCRWEDCSREQ KPFKAQYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCN KAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRG DYPRPPPQPREPGSNGQGRSPGQLPLGGYTDQREYTHSTSKPEECLQVKSIKTEKPMTSQ PSPGGQSTCSSDQSPVSTHPYGRVQLAVSAGRSPGEGLEESEEKEENEEADEECEEGEQA PIMDSTVSTASTAMLALQARRSVGRSLRWMEHVKMERLKQVNEALPRLGPLSPTPPPKVS TLPTILGKGSCLGRQWGVTAPQPPAHGELGSTELTVLNLLRDRRDSSGSATSSAYLSSSR RSSGISPCFSSRRSSQASQNEATMAAVYHRRLHNLSSTDSYDPISTDASRRSSEASHCGG GGGGMLSAGGCGGAFGLGVGGGGGSRGMLSLTPAQHYHLKAKYAAATGGPPPTPLPNMER MMGDALVRPHRCADGSPGSVNGHTGHSGYRRRVLYPGEGSANRNRRASDPVRSQAPDACS LPPVQRFSSLNNLHPLPPLSHHSIPENCSLSLQNSARSEGNMQRILQHSAYNPSIAEHAA LEALAMEEDGGAGLLLGDEDMLPDDLVQYLHSQVQSDSCAFMNVEEQLASSQRDPSYPSM EELEQIQSSGLDMSYSGSHGLQQQIAERRSPSSLPIQWNEVSSGSADRS >Takifugu rubripes GLI3 METQSQASSAAEKKKKVETIAATKGLVARNDISEKAVASSTTSNEDDSSGTPFHRERRNA ISSHAPTASGLDRSISEEPSTSTDDRPSLLKKEQHSSLPHLADHALPYRGTLFAMDPRNG YLDSHYAAPQFFPTFHPPVPIDDRHTQGRYIYDPSPVPPLHVPPALAGSPAFSDISLIRI SPQRNPSVGAESPFHPPHPYISPYMDYIRSLHSSPSISVLSATRGLSPADAPHAGLTTAE YYHQMALLAGHRSPYATDLLPSLAATASASGAVAPHVEYLHAMESSRFSSPRLPSRPSRK RPLPISPLSEHSFDLQTMIRNSPNSLVNILNNSRSSSSTSGSYGHLSAGAISPALSFAYP PTPVALHVHQQLIGRQPSIVGSAFGHSPPLIHPSPAFATQRPVPGIPPPGISASERSAIS SDSSQNKPTSESAVSSTGDPMHHKRSKLKPEEELPSPGAVSIQDHPDGMTLVKEEGDKDE SKQEPEVVYETNCHWENCCREFDTQEQLVQHINNDHIHGEKKEFVCRWEDCSREQKPFKA QYMLVVHMRRHTGEKPHKCTFEGCAKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSN ASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGDYPRP PPQPREPGTNGQGRSPGQLPLGGYTDQREYNHSTSKQEECLQVKSIKTEKPMTSQPSPGG QSTCSSDQSPVSTYPYSRVQLAPIMDSTVSTASTAMLTLQARRGVGRPLRWMEHVKMERL KQVNEALPRLGPLSPTPPPKVATLPNILGKGSCLGRQWGVTAPQPPINGELGSTELTVLN LLRDRRDSSGSAASSAYLSSSRRSSGISPCFSSRRSSQASQNEATTAAAHHRRLHNLSST DSYDPISTDASRRSSEASHCGGGAGGGGGGPLSGGCGGVFGLGVGGGGGSRGMLSLTPAQ HYHLKAKYAAATGGPPPTPLPSMERVMDDGGSNQTLPPLVRPHRCSESSWGNTGGYVGHS GSRRRVLYPGEGALNRNRRASDPVRTQAPDACGLPPVQRFSSLNNLHPLPPLAHHSIPEN CSLSLQSSTRSEGNMQRFLQHSTYNPSIAEHAALEALAMEEDGGSGFLLGDEDMLPDDLV QYLHSQVQSDSLSLLNIEDQLASSQRDTSYPSMEEFEQIQSSGLDMSYPGSHSLQHQIAE QKSPSSLPIQWNEVSSGSADKSPHRKQNQQTAYGRWTGSGNGCASAPFGRFQNMVVQQQV PLEFQNNCPNASQPQGACSVNPAVKLETLPNSCMELRGTRGTFGRSTFPQGLDGPLPQVF KQQPANGAPRQSHSQLKHHSTTPSQDGADPGSSLNNLSGLSHGAALSLHRQVHVPHPPNS YRTFARAQQGHNSSNMLTNTKQQLMRRNGDHCSLAHQVSGLKLEAPDQGYSESGYGQSLS YGEGDCKASSFLALKDQCLLGSITEPLGQSEGINGTAPVALLSPGADQVTSTVDSLGPPL DQGTSLDFGAILEDGFDQGSLGTSSRLTTPRASAAFHSVAPGLNNMAIGDMSSLLTTLAE ESKFLAIMQ >Danio rerio GLI3 MEPQFQTSSSTEKRMENVVGTNSAPTRTDISEKAVASSTTSNEDDSSGSPYHLERRNTIS AQTDVVNTSGKVSEEPSTSTDERLPLVKKELQSFLHRLADHTLPYRGTLFAMDLRSGYLD PHYTAPQFFRAFHHPVPIDDRHTQGRYIYEPSPVPSLHMPPALAASPTFSDISLIRISPH RNPSMGTDSPFNPSHPYINPYMDYIRSLHSSPSLSMVSAARGLSPADTHHTGLTTAEYYH QMALLVGHRSPYADLIPSVGSTTGPASSALHMEYLQAMESSRFPSPRLINRPSRKRPIPN SPSLSDPSFDLQAMIRTSPNSLVTILNNSRSSSSNSGSYGHLSAGTISPALSFAYPPTPV ALQMHQQLISRQPGIVGSAFGHSPPLMHSALAFSTQRPVPAIQTSSLAPTERSIVSNDSQ SKPTSESAVSSTGDPMNHKRSKLKPEEEPPSPRAVSMQEQMNGMTLVKEEGDKEEGKQEP EVVYETNCHWDGCCREFDTQEQLVHHINNDHIHGEKKEFVCRWEECSREQKPFKAQYMLV VHMRRHTGEKPHKCTFEGCSKAYSRLENLKTHLRSHTGEKPYVCEHEGCNKAFSNASDRA KHQNRTHSNEKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHVTKKQRGETYPRPPPQP REPGATTDQKEYTHATSKQDECLQVKSIKTEKPMTSQSSPGSQSSCSSDQSINGPHVSQG VQLTVNSIGLAGEVAMLEDMENEEEDEENREGEKEDAPIMDSTVSTATSSAATIVLQTHR SVGRPLRWMEHVKMERLRQVNGAVPRLGFLPPTPPRKGQAMPALTGKGQCLGRMTSVRVP PCPEPSNTELTILSLLHERRDSSGSNTSSAYLSSSRRSSGISPCFSSRCSSQASLSEYSP HRHIHNLSATDSYDPISTDASRRSSEASQYDGGSSSAVVFGGSGVFKGSGMGSRGDLNLT PAQHYSLKAKYAAATGGPPPTPLPSMGHINLKTHFALKEDRKDTGQLTLPPLVRSRRCSD GAHNSHDSQAVYQRKGTYFGGGPGKNDRRASDPTHHKQNLSSYGLPQVRHFSSLNNMTSS PNPASYGYSNREDHSLNLQNSTCHVDSFQSGLHSPCPPSIMEQSALENIFMNQDGLLLRV NENIQSDFMQYLHSQDQESIIIQDNHRPIFNPADDQNFLSPQQQQEGVEQEDTRIDLMPI QSNEVSSASADVTIPRQPFQRCGRWSDQSGSVSNAFGRFGNMVVQQQPIDFIDQHSALQH MGGISYGCRNSEQHLQVAKPAQEKSRMKTGIKTESSSTFQLESKHSNFGRPDFSHIFSAP IHQKCSQHTVVSQSYPQQNQITNQDSSNLFLQRPGNCSLLLAYRPQPAVNTSYSTRQDIN SHNVQSCHPQSLNNRLGTSCSLSNQVSVVKLDQVNHLQINSCSTIQQQKPVFIDKCFDPE ESKLSHAIVQSCLMESLMAEKERTSKVLLSSGVGQVTSKVERSPAEKVGLGICSIGGDSY DQGSVVSSSRLSNSHDSFAFHSVDPGTNNMAISDMNSLLTTLAEESKFLAIIQ >Branchiostoma floridae GLIA MASTSPGVTKEPERRPAESSESKSDKSRHHGEAKSAETSIKKEAASSSEYAHPRLEPSRPGFPHPPLISE HRSTYPYPSFGLDPRNGYVDPHFMSPVMPFHQPIPVDARTNEGRYTFDPHNVYHVPIHSPPFGGSPVLSD VSMLRLTPHRPHSDPTSPLHGPHPAFRLNPFFSPYHGTPPLSALSQARGLSPHDGMTAAEYYHMAAMSQQ RMYSDMPPLSGGSGSIAIDLPTDGSRFSTPRTAARHGRKRALSISPLSGECLDLNSMIRTSPNSLVAFIN GGSRSGSSASTGSYGHLSASAMRTESGAESKPGTQSSANMPFSAPMPMFPYPTSPAMQQFHNRLMRQKSP FHFGMPHASPFAAPLPAGMAMLAAQGAMPPSSSAATHTETKASLGDAFTMEPSESKRSKVKYEGSQGSPD DVPSTTFPAESRSETSMAEGTNEDAEPPVYETNCHWDGCSKEFDTQDQLVHHINNDHIHGEKKEFVCRWS ECTREQKPFKAQYMLVVHMRRHTGEKPHKCTEIMPQISLRTLPVLPFEGCNKAYSRLENLKTHLRSHTGE KPYVCEHEGCNKAFSNASDRAKHQNRTHSNAKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHQTKKHK TLGPTPRPRDPPSEKRDQDSVSSPPDSNGVHSSTTNPAASQGSPGQKPTEGHKPTGQTCDAQQSVYGSSP HHDSGVEMNANSGSLPDLSTLDDQVISDSSISSTVPTSRASGVMVAARPGLVPRAPRIGNKPSNQRRRMR LSSGTPGPTSPPRSDSVQLPPIEKTGSRGPSAQGSHSSVEAANRRTNELRASDLSQTSRTSSLGSLGSRK DSASTVSSYYSSRRSSEASPFPESIFSSRRSSQASPFPGINRRTSNGSLYSPNDSYDPISLGSSRKSSDA SSLSMNVNELGINIEQQQMLRARFIQATGRPPTAVCGNDSRPESRRGDRKEKENVEEPNPRRQSDLGHYN RLKGTPLPKEVKDGPHRRSSAPQKNDVVTNLPDVPRDHSFNKHTPLPPVTPQPPPQIKKAFSPSKVKQAF SPKSASTSMQGVAEEFPMDLIENEPDVIIPDEMVQFLNSQTGDDPREMVPNFEQVGTTPTFVEDIPPMQV NPIQGDGFSNMGSPQQAFSPNRQPMPPIQQQQAFNQSQQVLSPSRQSYKMSQPMGSQPLSPMEVNMAALD HSPNPPTYNASQMSPAQQFSPASYDPNLNSPSCRVQQNYSQMGMQSPVPNYASPTRQAQNMAPKLPNMQP QMLSPQQRQQSQQQQLQQQMQSQQQQMQQMQKLQQMQKMQQMQKMQQMQKMQQMQKMQQMQKMQQVQKMQ QMQQQQQQQQQAQMQNMQVQRQMQNMQKQSQLQQQMQNLQQQQRLQQQNLQQNYNMQQMQNLQSQMQLSP NVQQQMQNLQLSPSGQQYLPEGAQQMQYQANVQFYNLQNQSGRPLENPTQVNVVHSTIEPHHSPQRPDGA ADINLENVAMPTQNPMGFPAGNAGYTQDQSTNFVGGVNMSTPMVPPETPGSASNMVINDMSSLMASLAEE NRYLNMMG >Branchiostoma floridae GLIB MASTSPGVTKEPERRPAESSESKSDKSRHHGEAKSAETSIKKEAASSSEYAHPRLEPSRPGFPHPPLISE HRSTYPYPSFGLDPRNGYVDPHFMSPVMPFHQPIPVDARTNEGRYTFDPHNVYHVPIHSPPFGGSPVLSD VSMLRLTPHRPHSDPTSPLHGPHPAFRLNPFFSPYHGTPPLSALSQARGLSPHDGMTAAEYYHMAAMSQQ RMYSDMPPLSGGSGSIAIDLPTDGSRFSTPRTAARHGRKRALSISPLSGECLDLNSMIRTSPNSLVAFIN GGSRSGSSASTGSYGHLSASAMRTESGAESKPGTQSSANMPFSAPMPMFPYPTSPAMQQFHNRLMRQKSP FHFGMPHASPFAAPLPAGMAMLAAQGAMPPSSSAATHTETKAGEPSSSIVSSTMEPSESKRSKVKYEGSQ GSPDDVPSTTFPAESRSETSMAEGTNEDAEPPVYETNCHWDGCSKEFDTQDQLVHHINNDHIHGEKKEFV CRWSECTREQKPFKAQYMLVVHMRRHTGEKPHKCTEIMPQISLRTLPVLPFEGCNKAYSRLENLKTHLRS HTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNAKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPEAHQT KKHKTLGPTPRPRDPPSEKRDQDSVSSPPDSNGVHSSTTNPAASQGSPGQKPTEGHKPTGQTCDAQQSVY GSSPHHDSGVEMNANSGSLPDLSTLDDQVISDSSISSTVPTSRASGVMVAARPGLVPRAPRIGNKPSNQR RRMRLSSGTPGPTSPPRSDSIQLPPIEKTGSRGPSAQGSHSSVEAANRRTNELRASDLSQTSRTSSLGSL GSRKDSASTVSSYYSSRRSSEASPFPESIFSSRRSSQASPFPGINRRTSNGSLYSPNDSYDPISLGSSRK SSDASSLSMNVNELGINIEQQQMLRARFIQATGRPPTAVCGNDSRPESRRGDRKEKENVEEPNPRRQSDL GHYNRLKGTPLPKEVKDGPHRRSSAPQKNDVVTNLPDVPRDHSFNKHTPLPPVTPQPPPQIKKAFSPSKV KQAFSPKSASTSMQGVAEEFPMDLIENEPDVIIPDEMVQFLNSQTGDDPREMVPNFEQVRTTPTFVEDIP PMPVNPIQGDGFSNMGSPQQAFSPNRQPMPPIQQQQQAFNQSQQVLSPSRQSYKMSQPMGSQPLSPMEVS MAALDHSPNPPTYNASQMSPAQQFSPASYDPNLNSPSCRVQQNYSQMGMQSPVPNYASPTRQAQNMAPKL PNMQPQMMSPQQRQQSQQQQLQQQMQSMQSQQQQMQQMQKLQQMQKMQQMQKMQQMQKMQQMQKMQQMQK MQQVQKMQQLQQQQQQQAQMQNMQVQRQMQNMQKQSQLQQQMQNLQQQQRLQQQNLQQNYNMQQMQNLQS QMQLSPNVQQQMQNLQLSPSGQQYLPEGAQQMQYQANVQFYNMQNQSGRPLENPTQVNVVHSTIEPHHSP QRPDGAADINLENVALPTQNPMGFPAGNAGYTQDQSTNFVGGVNMSTPMVPPETPGSASNMVINDMSSLM ASLAEENRYLNMMG >Ciona savignyi GLI METAGKNDIDVLHQKCGKDFSREEKATPQTHLPPDHKIEGSEHHSRRSEAPKPGKQSAFF SSQDENEAREEAVVSSSTSPSDKRTKRSSSPDHNEHLRQQNDELRHQSRHQSVREAATST TTFEDEFEKQFHGNENLGVTSSDGRPPSCGTPLGKIKEETSSNNRKVMLLGNAHQFTKPS PSNRNMTSSQAGNTNCNGEDRRYPIGNPHTQVDPHSRDGRYPFEPRTMNNAPGFSGSPIH SDISLIPMSPQQSANPFNYNSSLEFYMGGLSQGGLRSPTMSILSQARNLSPHHSIQELEK LCYPYYNAHQSNMSVNGAQQNSNQSLPGNFSQNINPLAYYQLMQQQQRLLAVAARNDRNL ALSLEKQEDFGRFPSPLCRSRARKRPLSISPCFSDTGLDITAMIRTSPNSLLPFGGLTNS RSSSVASGGSYGHLAAGGISPTFGYQTPMMTSPQHLHAHLLSRQMQSSFAGQLMPGFPTN QGAFDKPNSRFDPNISTRNYLPHVGASAASNDMCNPHRDNKNFSKHSVDPQSPNVQFNNN NNNSNSIPGISPGGHGANEENDVVYDTNCSWVNCSLEFDTQEQLVHHINNDHIHGDKKEF VCRWIGCARDQRPFKAQYMLVVHMRRHTGEKPHRCTFEGCSKAYSRLENLKTHLRSHTGE KPYVCEYPSCTKAFSNASDRAKHQNRTHSNEKPYACKQAGCTKRYTDPSSLRKHVKTVHG PEAHVTKRMKAEREREGKREPNIKQEPGMDKDKRKGDAGGTKRTCHPLSPGSNPPSNDQN PPSNMNPRSNQSSCTSGSDVSVTPQNSPHMTSQNNDSGVDVNVGANEGDSDGDIVVDENP QPDSTSGGVGVQSRHRGTVRASLVPRLVNKKMQNLSIGGNIESYVDIGGYDDQRKLGMHK AESFTEVSSTTAFPAKQKNATFPRKLPLTPHRQVALLNQDRRDSGTVSDGSRKSSLASQN SRRSSQNTGGINVAGSYDPISLDSSRRSSSNVTSGSSALNPYQLHRLRSRFNENAGLPPP TPVDREGYTKSQLSRWLKDDTPIPDRGGYLYNPQQRPSLPQMGPPKPPMEDRRRSEPRSS ARTPLPPHLGGGVAFRRASDPTRKSPQMDPTRLPNVQRHNSWNSIHPLPGIKPQGCAYPG AVPCNPSNQPPMQQVQRQRSISNSSNYYGGESGYHSHGSNMALHQPSYQVNEQVLMENFN NDVINGDVTYNGQVYGKSDHWHQQTTPHPHQTMTPASVGSMPPHQRFPQNGHINQNPFPR SFNNNPNVGPNKGVQDANATRYYGNPHFNPNAQMGGQVHGHPTMRPQKMTQQNVTQQFGN PDFMQLPYNAPSPYIAQRQSVQNQGRSPNMINSGNVEMHLGHQNRTANQITPRPPVSSTS SNQNRMRLQRVRQSGSSSVTSYNQAPSVTSQSNGQAGRTNYTPDAQIPDEFLQQEFIDSI PELHPETHRENEPNENQPYVKMAADSTTGPDLDGITGNFCYQDDDAMSGTNTDVTLPPMS AFSSRMATPMMGKYPPQIPTNQHPASNMAINSMSSMLSTLEEENKYLNLLPQ >Strongylocentrotus purpuratus (XP_001195249) MSSVSKQVTEPNNNQVTSSVDLDNHQSKGMDDPNTVSSTSHMEGSPSAPAPGGDHRDDDGAHGGEEDIPV VTDCEWDDCHRKFDTLDQLVQYDNHLFFFLLKFVCNLLQHINNDHIHNERKEFICHWRDCIREEKPFKAQ YMLVVHMRRHTGEKPHKCSFEGCYKAYSRLENLKTHLRSHTGERPYVCEFQGCTKAFSNASDRAKHQNRT HSNAKPYACKITGCTKRYTDPSSLRKHVKTVHGPEAHVTKRQRGDKRDPPSGSGGEKEGRKGDDMDKKSP GDVKPITKAISVSSNSTNNNRTKGVPQECHTSAHQSVHLSAPVNDYSSSPHNDSGVEMNATGGSIGDLTS IDDEKLIQDDQISSNVGDLGDGIGHRGRMGRRGGGGGRGSLTVTTAPTIIGRTTSPFMERSIKIKAGMSR PTHKAKTGVHILPQMPPPPPPPLQQQLPPVINNNNHGIDYKPKARNIEKLIFEERCDSSQSMTGNLDNLG NRRGSDHSTVSSYFSGRSSEASPFFMGSQFSSRRSSQASSYMSSMSSRRTSGASQWSGHMGMNSPYDPIS IGSSRRSSEASSLNGPTGLPGLTLAQQRSLQARYEQTIMQQNSGDERFGMTPSPMPPPGYRRLSGVASMP PHPPRTPLPNEIPGNEIRRGSEPISSNQNSHMNRRYSSFNNKQPLPLPENMKNFRPAFHNIHHPPTIHEQ DGGSGREQWQNIPQNHYEHGTIPEESMDTGGSGGPEEFMFPDEMVQFLDDQCKQEMQWTGQRQMPAGGGG GDGGRGFNQPHGNNHPGHNQMQGGYNMQPLNSDALDHVQQIVPETMESETENKMPYNSQGASAGYPQQEN VVNPTISNMAVTDMSSMLTSLAEENRFLSIM >Drosophila melanogaster (Ci) MDAYALPTYFPLAYSELQFLASRRAAAVAAAATVLPGSPCINQHHPTDVSSSVTVPSIIP TGGTSDSIKTSIQPQICNENTLLGNAGHQHNHQPQHVHNINVTGQPHDFHPAYRIPGYME QLYSLQRTNSASSFHDPYVNCASAFHLAGLGLGSADFLGSRGLSSLGELHNAAVAAAAAG SLASTDFHFSVDGNRRLGSPRPPGGSIRASISRKRALSSSPYSDSFDINSMIRFSPNSLA TIMNGSRGSSAASGSYGHISATALNPMSHVHSTRLQQIQAHLLRASAGLLNPMTPQQVAA SGFSIGHMPTSASLRVNDVHPNLSDSHIQITTSPTVTKDVSQVPAAAFSLKNLDDAREKK GPFKDVVPEQPSSTSGGVAQVEADSASSQLSDRCYNNVVNNITGIPGDVKVNSRLDEYIN CGSISIPSNEYDCANADTTDIKDEPGDFIETNCHWRSCRIEFITQDELVKHINNDHIQTN KKAFVCRWEDCTRGEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCFKAYSRLENLKTHLRS HTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYICKAPGCTKRYTDPSSLRKHVK TVHGAEFYANKKHKGLPLNDANSRLQQNNSRHNLQEHNIDSSPCSEDSHLGKMLGTSSPS IKSESDISSSNHHLVNGVRASDSLLTYSPDDLAENLNLDDGWNCDDDVDVADLPIVLRAM VNIGNGNASASTIGGSVLARQRFRGRLQTKGINSSTIMLCNIPESNRTFGISELNQRITE LKMEPGTDAEIKIPKLPNTTIGGYTEDPLQNQTSFRNTVSNKQGTVSGSIQGQFRRDSQN STASTYYGSMQSRRSSQSSQVSSIPTMRPNPSCNSTASFYDPISPGCSRRSSQMSNGANC NSFTSTSGLPVLNKESNKSLNACINKPNIGVQGVGIYNSSLPPPPSSHLIATNLKRLQRK DSEYHNFTSGRFSVPSYMHSLHIKNNKPVGENEFDKAIASNARRQTDPVPNINLDPLTNI SRFSTTPHSFDINVGKTNNIASSINKDNLRKDLFTVSIKADMAMTSDQHPNERINLDEVE ELILPDEMLQYLNLVKDDTNHLEKEHQAVPVGSNVSETIASNHYREQSNIYYTNKQILTP PSNVDIQPNTTKFTVQDKFAMTAVGGSFSQRELSTLAVPNEHGHAKCESFHHQSQKYMNT DIGSKQQSALPSAHQRQTEKSNYNQIIDSSMTSLPELNVDSIYPRNETENIFKVHGDHDN EIQCGIISQSQMSPSTNLNNDGQFSTVNMQPITTSKLFPPEPQKIVCDTQASNTSVMHLD TYQRTLEYVQSCQNWMETNNTSTNQIQSLPGMPVNNTLFPDVSSSTHPYHGTNMVINDMT TSLTSLLEENRYLQMMQ >Apis mellifera(XP_624136) LSSSTTAIGTAATGGGGGASSGASGGGGGGSGGGGGGAAGNGTSGGDFLRRSHPLSEHTA LHPAYRLNYMDHLYHQLQASTHSPNASLHGLGGLGPEYLLHAAGPASTLASSEFPFSIDV SASSRLGSPRASAIRASRKRALSSSPYSDRFDIDSMIRFSPNSLASIVNGSRSSSASGSY GHLSAAMSPALGMHPGMAPHLQQLQAHLLRSAAAAALLPHAHPLQRPAPPPPPPHPHPHA HGLSPHSQLYPGVPPHSTASATLGPHGGGLPPKTESAESCRKASESTTRSVTAEADTSSR RTSTKVKREPATTTTNATTTTAPPTHPQGLSPSEDLRDEPGDFIETNCHWRDCGLEFPTQ DDLVKHINNDHIHANKKSFVCGWEECSREEKPFKAQYMLVVHMRRHTGEKPHKCTFEGCF KAYSRLENLKTHLRSHTGEKPYTCEYPGCSKAFSNASDRAKHQNRTHSNEKPYVCKAPGC TKRYTDPSSLRKHVKTVHGAEFYANKKHKGGGGDGGGSDEAGAGGHSPSRSEDLHPKTPS LSSPSVKSESEANSPPSMMQQQGSPLVGGCNDEVAGVGTLTGDGVALAEEPWNEEPDDLD IADLPVALRAMVGGMESQQQQQPPPPASRNRLKGRLNAKGMPNLPVSVSSMRGTRGMGPQ GNIGDLNRRITDLKMEGGGSARQTSLSDLQLRLQPLSEPRRDSNSTVSTYYGSMKSTDFG SRRSSQASGVSAVRMGQTGPGSFYDPISPGTSRRSSQMSTTSGRMNPPNLQGPYSTSNLV VQTQNMSLQGIQGIPGDWNGPSGHCTQLSGDRRMSEPTRGHQTQRNSPPVPPRPRSAQLP EHHPNQEVILDEVGEGEMVENKLVIPDEMMQYLNQVQAGGTQVNCRSPLPICQSPICTNP LHYQRQIQPTCNYNQSHQQTCYPSSQSAQPCTNYQNTSPSPYNQCPSSRPPQSNSQYCPP PTYPLQPNGGQVLSPAAGQVMSPGSHYAPSHISDQPLTSPAAGALAPQHPPQNLPQNSAQ LTRNCPQNHMHHGYYPNYNCQGQMNANCTGNPNGQVNHHTNSTCAPPNHNTMTQQQCVQM RSAGNCQQLSSHCTQQPVIPNQTTMSHPNTQCGQVANQCTRPIVTPNGQMPNLHSVQQTT VPNQCAQMSPHCSQLNMNNQAKPITNMTNLQGCQQQVQQPTTPCLQMANCAHPNSGHRPI TDNTLSKRTSPQLCSAQQTNCRMQQQQHTCTHNCQARTNPPNHQYNCNCQWGYDQCYHEQ TGTAMPEIQCRDISQSQQGSPIKPPQGMRQDSYRRTLEYVQQCRNWSGNAQTHETNVSSS THPISLPQPLPSSANMVVNDMTSSLSSLLEENRYLQMIQ >Caenorhabditis elegans (Tra) MAPSTEDPDTVVEAQRRGSFSKKKNANGWNKVELVDQCAKQMGSEDKQPGGGDVKTENDP SKNGLGSATSNFIQSSVPPSHQTLSNPLQLSPPAEASVAQQSGASQVFPTFQAALGASSD ELLQPNATSSSTSSSASTSSIVPVVKFTNQTAPNGSTVATSVGQNVRLTINGKRVGRPPG TFKRPQNNAANSSNSGNDSDMMGDHDLTCRWKSCNSSFQTLKALVDHVQESHVQSTEQEH HAWRCEWEGCDRNETFKALYMLIVHVRRHTGEKPNKCEYPGCGKEYSRLENLKTHRRTHT GEKPYKCEFADCEKAFSNASDRAKHQNRTHSNLKPYSCQIPQCTKSYTDPSSLRKHIKAV HGDDEYEKAKKSRPANYSNRRRPDHRLAPPTGAMSHPYLATPNSGASVVAHSSVHQQNFI NMALAQHHHNAQRAQQLMAATGNVMPMMDPASAAAAAQAQAHHQAQAQMLQTHMMQQAQI QAAAQMQAQVQHQAAMQAHAMQQAQMVLQNNLLGAQSLLSPFSPLLPPSRAPNVMAMLQT PPTPTSVAPMFDIMTSRAPMAPVVSAPTAPAPLVPAPVPASPVFDELREQMREVEPLQQQ QQQEPMDQDLQDIRVDGDSDDEDEEEPRTPSGALLLPRGGNNGDGGFGGSGSSRASSGSG TMELSAAPISQNGSRASGSGERGMRSFLIADILQLAADFQNERLLSDVLDLAIFDTRDVR SLHNIYQVYIRAHKAIPITRRPLDWNETHQLHNLYHDPRFNRAEHQDSPAIRDRDTRFWR TIAEANTMRQRQIEPVPLDDDDEGYFDEMVHRVQNGRLNEQFMEGFESDDDDGFEDEDDV PGLGIAVYRGRRRVRREALKQANLDIQEAETAGRNVGGFGDEEDRNNRGHDQDRSFLDHY YPPMVVVVETESPQIVRDQEMMRQFEEAKKNVETDEIKKRAEAMQFGTSSSHHHTKTLLI QRALFDKTSSVRRSLLQFITISVDQEELRQSCHATSAPQGAHVVHNVVDEFDSIMRAQED SNNRILLSLDIPAPSAVTGVSGSITHADNSALQLQQEQPTSSFSSWFPEDDPIYALPPPP PPPAPPRRRRSADNKDDSENIPKKPRHQF