>Homo sapiens_SHC1(ENSP_401303)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Gorilla gorilla_SHC1(ENSGGOP_13082)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPSAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQNLDKARQAVGGAGPPNPAVNGSAPRDLFDMKPFEDALRVPPPPQSVSM
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Macaca mulatta_SHC1(ENSMMUP_8657)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARSTAPSAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQNLDKVRQAVGGAGLPNPAVNGSAPRDLFDMKPFEDALRVPPPPQSVSM
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Mus musculus_SHC1(ENSMUSP_91940)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLKLANPAGGRLGPKGEPGKAAEDGEGSAGAALRDSGLLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAARPTLPSAQMSSHLGATLPIGQHAAGDHEVRKQMLPPPPCPGRELFDD
PSYVNIQNLDKARQAGGGAGPPNPSLNGSAPRDLFDMKPFEDALRVPPPPQSMSMAEQLQ
GEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRT
KDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVDRKV

>Canis familiaris_SHC1(ENSCAFP_25262)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDESPTTLCS
FFPRMSNLKLANPAGEPGRASKDGEGTGGAAVLDSAPLPLLQDMNKLSGGGGRRTRVEGG
QLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQV
TREAISLVCEAVPGAKGATRRRKPCSRPLSAILGRSNLKFAGMPITLTVSTSSLNLMAAD
CKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQA
FELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMR
LREAAPLGAVRPTPHVVQTPSHLGATLPVGQPVGGDPEIRKQMPPPPPCPGKELFDDPSY
VNVQNLDRARQAGGGAGPPNPAINGSVPRDLFDMKPFEDALRVPPPPQAVAMAEQLRGEP
WFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDH
RFESVSHLISYHVDNHLPIISAGSELCLQQPVERKL

>Myotis lucifugus_SHC1(ENSMLUP_2181)
MDLLPPKPKYNPLRNESLSSLEEGASGSSPPEELPSPSASSLGPILPPQAGDDSPTTLCS
FFPRMSNLKLANPAGARPGPKGEPGRVAEDGEGVAGAAVPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGASRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAPQGPARPTLPSAQNPSHLGATLPVGQPAGGDPEVHKQMPPLPPCPAGR
EIFDDPSYVNIQNLDKARQAGGGAGPPNLAVNGSAPRDLFDMKPFEDALRVPPPPQSVAM
AEQLRGEPWFHGKLNRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Pteropus vampyrus_SHC1(ENSPVAP_762)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLKLANPAGGRLGPKAEPGRAAEDGEGTTGAAVPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGATRPTPPSAQPPTQLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQHLDKARHAGAGAGPPGLAVNGGAPRDLFDMKPFEDALRAPPPPHSVAM
AEQLRGEPWFHGKLSRREAEALLQLDGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISHHMDNHLPIISAGSELCLQQPVTRRP

>Xenopus tropicalis_SHC1(ENSXETP_33635)
MDLLPKTKYNHLRNESVSSVEEALAAGPLSPSVEIMVSLPSSASSSSLAPMLPLAELSSE
SEESPTTLCSFFPKMANLKLSNPANLLNLRSFSSSMGGKESASPGEQGDTPNEGSSPESG
RTFTVFSQDMNKLSCGRKSRVEGGQLAGDEWTRHGSFVNKPTRGWLHPDDKVMGPGVPYL
VRYMGCVEVLQSMRALDFNTRTQVTREAISLVCDAVPGAKGAMRRRKTCGRSLNSILGKS
NLKFAGMPITLTVSTSSLNLMASDCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVN
QRACHILECPEGLAQDVISTIGQAFELRFKQYLKNPPKLVTPHDRMAGFDGSAWDEEEEE
LPDHAYYNDFPGKEPPIGGVVDMRLRDGVAPAVPRQSPNHMGATLPVGQVSGAEQDSRKP
QPTVQVPCSRPPNRPDLFDDPSYVNVQNLEKSRQPLRQQTARDPMGTNAVGTTTNFPVAP
VEPFEDALPSAQAVVSMEDQLKRESWYHGKMNRKEAERLLKVNGDFLVRESTTTPGQYVL
TGLQCGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNRLPIISAGSELCLQQPVERR
Q

>Danio rerio_SHC1(ENSDARP_89171)
MEYVDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDIVVSTSGVSYTVRY
MGCVEVLQSMRALDFNTRTQVTREAISVVCEAVPGAKGAQRRRKPSSRCLSSILGKSNLQ
FAGMTITLTVSTSSLNLMAIDCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRA
CHILECSEGLAQEVISTIGQAFELRFKQYLKNPPKVVTPHDRMAPFDGSAWEEEEEDLAP
PPEVPYYNNFPGKQPPPGGLVDMRTRPGHSTGPTLPYGQPSQNDIHKQPLPPLPVGVKDG
GLFDDPSYVNVDKPRLPASAAANGNAHRDAFDMKPFDAALVVSGAVALPLAEQLQNEPWF
HGPLSRRQAERLLTKDGDFLVRESGTTPGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRF
ESVSHLISYHMDNRLPIISAGSEVCLQQPVDRKA

>Takifugu rubripes_SHC1(ENSTRUP_15882)
MELAPKTKYTHFRSESLSSTDETNSNPSSVPPSSPVSPLTPSPGMPSSLSSSSLTPILPP
CSPHPAENSPTTLCSFFPRMGSLRLGVSATLLPSFKTASRPQNTRAPVESSGDDQSRARP
SPPVHHPLPPLTDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVSTS
GVSYTVRYMGCVEVLQSMRALDFSTRTQVTREAIAVVCEAVPGAKGAQRRRKPSSRCLSS
ILGKSNLQFAGMTISLTVSTSSLNLLACDCKQIIANHHMQSISFASGGDPETAEYVAYVA
KDPVNQRACHILECSEGLAQEVISTIGQAFELRFKQYLKNPPKLVTPHDRMAPFDGSAWE
EEDEEPPPPPDVPYYNNFPGKQPPPGGLIDMRTRPGATLVRSMHISPTPIEETETIPYGQ
PGQNDIHKQPLPPLPAGAKEGGLFDDPSYVNVDKPRPRVASNGNMHRDAFDMKPFDDALG
VSGHSGTSSASAAPPLVQQLQCEAWFHGGLSRKEAERLLTRDGDFLVRESGTTPGQYVLT
GQQGGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNRLPIISAGSEVCLKQPVERRA

>Tetraodon nigroviridis_SHC1(ENSTNIP_21499)
MELSPKTKYTHFRSESLSSTDETNSNLSSFPPSSPVTPLTPSPGVPSSHSSSSLTPILPP
CSPRPAENSPTTLCSFFPRMGSIRLGVSATLLPSLKIASRPQNTQAPAESSGEDRSSSSS
LQDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDSVVSTTGVSYTVRYMG
CVEVLQSMRALDFSTRTQVTREAISVVCEAVPGAKGAQRRRKPSSRCLSSILGKSNLQFA
GMTISLTISTSSLNLLACDCKQIIANHHMQSISFASGGDPETAEYVAYVAKDPVNQRACH
ILECSEGFAQEVISTIGQAFELRFKQYLKNPPKLVTPHDRMAPFDGSAWEEEDEETAPPP
DVPYYNNFPGKQPPPGGLIDMRTRPGATLEHNKWKLSNANVNGSFFSVAPCLQPYGQPGQ
NDIHKQPLPPLPAGAKEGGLFDDPSYVNVDKPRPPAASNGNMHRDAFDMKPFDDALGVSG
HGGPSSASAAPPLVQQLQCEAWFHGGLSRKEAERLLTRDGDFLVRESGTTPGQYVLTGQQ
GGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNRLPIISAGSEVCLKQPVERRA

>Gasterosteus aculeatus_SHC1(ENSGACP_15982)
MELVPKTKYTHFRSESLSSTDETNSDPSPLPPSSPATPLTPSPGLPPSLSSSSLAPILPP
SSPRQAENSPTTLCSFFPRMGSLRLGVSATLLPGGDRSSSGSSPPLHRPTAPLTAPSPPP
RPTLQDMNRLGGASRKARSEGAARKARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVT
TAGVSYSVRYMGCVEVLQSMRALDFNTRTQVTREAISVVCEAVPGAKGAQRRRKPSSRCM
TSILGKSNLQFAGMTISLTISTSSLNLLASDCKQIIANHHMQSISFASGGDPDTAEYVAY
VAKDPVNQRACHILECSEGLAQEVISTIGQAFELRFKQYLKNPPKLVTPHDRMAPFDGSA
WEEEEEDDNAAAAAAPPPDVPYYNNFPGKQPPPGGLVDMRSRPGATLPREAALMSNATFA
QKGCRLAELLPYGQPGQNDIHKQPLPPLPVGAKEGGRELFDDPSYVNVDKPRHPVAANGN
AHRDAFDMKPFDDALGVSGPGGASSSTAAPPPLVQQLQCEAWFHGSLSRREAERLLTRDG
DFLVRESGTTAGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNSLPI
VSAGSEVCLQQPVERRA

>Oryzias latipes_SHC1(ENSORLP_12223)
LVPKTKYTHFRSESLSSNDDTNSNPSSFPPSSPATPLTPSPGIPSSLSSSSLTPILPPTS
PRPAENSPTTLCSFFPRMSSLRLGVTATLLPGLKASSRSQPSQLAVESSGDDRSNSSSSP
PLHQPAPLLTAPSPPPRPPLQDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWL
HSDSVVSTTGVSYTVTYMGCVEVLQSMRALDFNTRTQVTREAIAVVCEAVPGAKGARRRK
PSSRCLTSILGKSNLQFAGMPISLTISTSSLNLLASDCKQIIANHHMQSISFASGGDPDT
AEYVAYVAKDPVNHRACHILECTEGLAQEVISTIGQAFELRFKQYLKTPPKLVTPHDRMA
PFDGSAWDEEDDEIAPPPEVPYYNNFPGKQPPPGGIIDMRTRSGATLVRRHPLMHTTQHI
RIQRGLQHRDDKPLYGQQGQNDIHKQPLPPLPGAKEGTRELFDDPSYVNVDKPRPPLAAN
GNANRDAFDMRKLDGKRKKKLLEPNIIEEPLDDALGVSGTSAPPMVQQLQNEIWFHGSLT
RREAERLLTRDGDFLVRESGTTPGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRFGSVSH
LISYHLDNRLPIVSAGSEVYLQQPVERRA
>Homo sapiens_SHC1(ENSP_401303)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSM
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Gorilla gorilla_SHC1(ENSGGOP_13082)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARPTAPSAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQNLDKARQAVGGAGPPNPAVNGSAPRDLFDMKPFEDALRVPPPPQSVSM
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Macaca mulatta_SHC1(ENSMMUP_8657)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGAARSTAPSAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQNLDKVRQAVGGAGLPNPAVNGSAPRDLFDMKPFEDALRVPPPPQSVSM
AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Mus musculus_SHC1(ENSMUSP_91940)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLKLANPAGGRLGPKGEPGKAAEDGEGSAGAALRDSGLLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAARPTLPSAQMSSHLGATLPIGQHAAGDHEVRKQMLPPPPCPGRELFDD
PSYVNIQNLDKARQAGGGAGPPNPSLNGSAPRDLFDMKPFEDALRVPPPPQSMSMAEQLQ
GEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRT
KDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVDRKV

>Canis familiaris_SHC1(ENSCAFP_25262)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDESPTTLCS
FFPRMSNLKLANPAGEPGRASKDGEGTGGAAVLDSAPLPLLQDMNKLSGGGGRRTRVEGG
QLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQV
TREAISLVCEAVPGAKGATRRRKPCSRPLSAILGRSNLKFAGMPITLTVSTSSLNLMAAD
CKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQA
FELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMR
LREAAPLGAVRPTPHVVQTPSHLGATLPVGQPVGGDPEIRKQMPPPPPCPGKELFDDPSY
VNVQNLDRARQAGGGAGPPNPAINGSVPRDLFDMKPFEDALRVPPPPQAVAMAEQLRGEP
WFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDH
RFESVSHLISYHVDNHLPIISAGSELCLQQPVERKL

>Myotis lucifugus_SHC1(ENSMLUP_2181)
MDLLPPKPKYNPLRNESLSSLEEGASGSSPPEELPSPSASSLGPILPPQAGDDSPTTLCS
FFPRMSNLKLANPAGARPGPKGEPGRVAEDGEGVAGAAVPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGASRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAPQGPARPTLPSAQNPSHLGATLPVGQPAGGDPEVHKQMPPLPPCPAGR
EIFDDPSYVNIQNLDKARQAGGGAGPPNLAVNGSAPRDLFDMKPFEDALRVPPPPQSVAM
AEQLRGEPWFHGKLNRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL

>Pteropus vampyrus_SHC1(ENSPVAP_762)
MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS
FFPRMSNLKLANPAGGRLGPKAEPGRAAEDGEGTTGAAVPDSGPLPLLQDMNKLSGGGGR
RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALD
FNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSS
LNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDV
ISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPL
GGVVDMRLREGAAPGATRPTPPSAQPPTQLGATLPVGQPVGGDPEVRKQMPPPPPCPAGR
ELFDDPSYVNVQHLDKARHAGAGAGPPGLAVNGGAPRDLFDMKPFEDALRAPPPPHSVAM
AEQLRGEPWFHGKLSRREAEALLQLDGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPE
GVVRTKDHRFESVSHLISHHMDNHLPIISAGSELCLQQPVTRRP

>Xenopus tropicalis_SHC1(ENSXETP_33635)
MDLLPKTKYNHLRNESVSSVEEALAAGPLSPSVEIMVSLPSSASSSSLAPMLPLAELSSE
SEESPTTLCSFFPKMANLKLSNPANLLNLRSFSSSMGGKESASPGEQGDTPNEGSSPESG
RTFTVFSQDMNKLSCGRKSRVEGGQLAGDEWTRHGSFVNKPTRGWLHPDDKVMGPGVPYL
VRYMGCVEVLQSMRALDFNTRTQVTREAISLVCDAVPGAKGAMRRRKTCGRSLNSILGKS
NLKFAGMPITLTVSTSSLNLMASDCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVN
QRACHILECPEGLAQDVISTIGQAFELRFKQYLKNPPKLVTPHDRMAGFDGSAWDEEEEE
LPDHAYYNDFPGKEPPIGGVVDMRLRDGVAPAVPRQSPNHMGATLPVGQVSGAEQDSRKP
QPTVQVPCSRPPNRPDLFDDPSYVNVQNLEKSRQPLRQQTARDPMGTNAVGTTTNFPVAP
VEPFEDALPSAQAVVSMEDQLKRESWYHGKMNRKEAERLLKVNGDFLVRESTTTPGQYVL
TGLQCGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNRLPIISAGSELCLQQPVERR
Q

>Danio rerio_SHC1(ENSDARP_89171)
MEYVDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDIVVSTSGVSYTVRY
MGCVEVLQSMRALDFNTRTQVTREAISVVCEAVPGAKGAQRRRKPSSRCLSSILGKSNLQ
FAGMTITLTVSTSSLNLMAIDCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRA
CHILECSEGLAQEVISTIGQAFELRFKQYLKNPPKVVTPHDRMAPFDGSAWEEEEEDLAP
PPEVPYYNNFPGKQPPPGGLVDMRTRPGHSTGPTLPYGQPSQNDIHKQPLPPLPVGVKDG
GLFDDPSYVNVDKPRLPASAAANGNAHRDAFDMKPFDAALVVSGAVALPLAEQLQNEPWF
HGPLSRRQAERLLTKDGDFLVRESGTTPGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRF
ESVSHLISYHMDNRLPIISAGSEVCLQQPVDRKA

>Takifugu rubripes_SHC1(ENSTRUP_15882)
MELAPKTKYTHFRSESLSSTDETNSNPSSVPPSSPVSPLTPSPGMPSSLSSSSLTPILPP
CSPHPAENSPTTLCSFFPRMGSLRLGVSATLLPSFKTASRPQNTRAPVESSGDDQSRARP
SPPVHHPLPPLTDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVSTS
GVSYTVRYMGCVEVLQSMRALDFSTRTQVTREAIAVVCEAVPGAKGAQRRRKPSSRCLSS
ILGKSNLQFAGMTISLTVSTSSLNLLACDCKQIIANHHMQSISFASGGDPETAEYVAYVA
KDPVNQRACHILECSEGLAQEVISTIGQAFELRFKQYLKNPPKLVTPHDRMAPFDGSAWE
EEDEEPPPPPDVPYYNNFPGKQPPPGGLIDMRTRPGATLVRSMHISPTPIEETETIPYGQ
PGQNDIHKQPLPPLPAGAKEGGLFDDPSYVNVDKPRPRVASNGNMHRDAFDMKPFDDALG
VSGHSGTSSASAAPPLVQQLQCEAWFHGGLSRKEAERLLTRDGDFLVRESGTTPGQYVLT
GQQGGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNRLPIISAGSEVCLKQPVERRA

>Tetraodon nigroviridis_SHC1(ENSTNIP_21499)
MELSPKTKYTHFRSESLSSTDETNSNLSSFPPSSPVTPLTPSPGVPSSHSSSSLTPILPP
CSPRPAENSPTTLCSFFPRMGSIRLGVSATLLPSLKIASRPQNTQAPAESSGEDRSSSSS
LQDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDSVVSTTGVSYTVRYMG
CVEVLQSMRALDFSTRTQVTREAISVVCEAVPGAKGAQRRRKPSSRCLSSILGKSNLQFA
GMTISLTISTSSLNLLACDCKQIIANHHMQSISFASGGDPETAEYVAYVAKDPVNQRACH
ILECSEGFAQEVISTIGQAFELRFKQYLKNPPKLVTPHDRMAPFDGSAWEEEDEETAPPP
DVPYYNNFPGKQPPPGGLIDMRTRPGATLEHNKWKLSNANVNGSFFSVAPCLQPYGQPGQ
NDIHKQPLPPLPAGAKEGGLFDDPSYVNVDKPRPPAASNGNMHRDAFDMKPFDDALGVSG
HGGPSSASAAPPLVQQLQCEAWFHGGLSRKEAERLLTRDGDFLVRESGTTPGQYVLTGQQ
GGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNRLPIISAGSEVCLKQPVERRA

>Gasterosteus aculeatus_SHC1(ENSGACP_15982)
MELVPKTKYTHFRSESLSSTDETNSDPSPLPPSSPATPLTPSPGLPPSLSSSSLAPILPP
SSPRQAENSPTTLCSFFPRMGSLRLGVSATLLPGGDRSSSGSSPPLHRPTAPLTAPSPPP
RPTLQDMNRLGGASRKARSEGAARKARVEGGQLGGDEWTRHGSFVNKPTRGWLHSDGVVT
TAGVSYSVRYMGCVEVLQSMRALDFNTRTQVTREAISVVCEAVPGAKGAQRRRKPSSRCM
TSILGKSNLQFAGMTISLTISTSSLNLLASDCKQIIANHHMQSISFASGGDPDTAEYVAY
VAKDPVNQRACHILECSEGLAQEVISTIGQAFELRFKQYLKNPPKLVTPHDRMAPFDGSA
WEEEEEDDNAAAAAAPPPDVPYYNNFPGKQPPPGGLVDMRSRPGATLPREAALMSNATFA
QKGCRLAELLPYGQPGQNDIHKQPLPPLPVGAKEGGRELFDDPSYVNVDKPRHPVAANGN
AHRDAFDMKPFDDALGVSGPGGASSSTAAPPPLVQQLQCEAWFHGSLSRREAERLLTRDG
DFLVRESGTTAGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNSLPI
VSAGSEVCLQQPVERRA

>Oryzias latipes_SHC1(ENSORLP_12223)
LVPKTKYTHFRSESLSSNDDTNSNPSSFPPSSPATPLTPSPGIPSSLSSSSLTPILPPTS
PRPAENSPTTLCSFFPRMSSLRLGVTATLLPGLKASSRSQPSQLAVESSGDDRSNSSSSP
PLHQPAPLLTAPSPPPRPPLQDMNRLGGASRRARVEGGQLGGDEWTRHGSFVNKPTRGWL
HSDSVVSTTGVSYTVTYMGCVEVLQSMRALDFNTRTQVTREAIAVVCEAVPGAKGARRRK
PSSRCLTSILGKSNLQFAGMPISLTISTSSLNLLASDCKQIIANHHMQSISFASGGDPDT
AEYVAYVAKDPVNHRACHILECTEGLAQEVISTIGQAFELRFKQYLKTPPKLVTPHDRMA
PFDGSAWDEEDDEIAPPPEVPYYNNFPGKQPPPGGIIDMRTRSGATLVRRHPLMHTTQHI
RIQRGLQHRDDKPLYGQQGQNDIHKQPLPPLPGAKEGTRELFDDPSYVNVDKPRPPLAAN
GNANRDAFDMRKLDGKRKKKLLEPNIIEEPLDDALGVSGTSAPPMVQQLQNEIWFHGSLT
RREAERLLTRDGDFLVRESGTTPGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRFGSVSH
LISYHLDNRLPIVSAGSEVYLQQPVERRA

>Homo sapiens_SHC2(ENSP_264554)
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA
DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA
AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR
EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ
VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL
RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT
QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL
DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE
QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV
VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP

>Pan troglodytes_SHC2(ENSPTRP_17238)
YMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLR
FAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRA
CHILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVTLPPERLAGPEESAWGDEEDSLEH
NYYNSIPGKEPPLGGLVDSRLALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGD
GYVQADARGPPGHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTA
APTVEDQWPSPPTRRSDGDFHVRESVTNPRLYVLTGMHAGQPKRLLVLDTEGV

>Macaca mulatta_SHC2(ENSMMUP_32034)
QYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNL
RFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQR
ACHILECCEGLAQSVISTVGQAFELRFKQYLHSPPKVALPPESLEMNPQRQAGGWDSNSG
LPAPSKSSSCGGLAPLGPACATRRRLSSQPTLDTSDEGPSASLRDARSLPWDVGSTGAAP
PGDGYVQADARGPPDLEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAG
MTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSV
TNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELH
LRGVVSREP

>Mus musculus_SHC2(ENSMUSP_129491)
MTQGPGGRAAPEPEAPTTFCALLPRMPQWKFAAPGSFLGRGPAATRVAGVAEAQPEPGVP
ALAAVLGACEPRCAAPCPLPALGRCRGSGTRGARVTPDVADEWVRKGGFIHKPAHGWLHP
DARVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP
NKALASILGKSNLRFAGMSISVNISVDGLNLSVPATRQIIANHHMQSISFASGGDTDMTD
YVAYVAKDPINQRACHILECCEGLAQSVISTVGQAFELRFKQYLHSPPKAVVPPERLTGL
EELAWGDDDAAADHNYYNSIPGKEPPLGGLVDSRLAVTQPCALATLGGLGQGMTPVWRDA
RGLPWDMGPSGAAPPGDGYVQADARGPHDYEEHLYVNTQGLDAVELEDTAEAPLQFEDSP
KKDLFDMRPFEDALKLHACSVAAGITAASPPLEDQWPSPPTRRAPIAPTEEQLRQEPWYH
GRMSRRAAEKLLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFE
SISHLIDYHLKNGLPIVAAESELHLRGVVSREP

>Canis familiaris_SHC2(ENSCAFP_29189)
MTQGPGGRTPPAPPAPPEPEAPTTFCALLPRMPEWKFAAPAGFLGRGPAAARTAGGAGGA
GGAGGAGGADPQPEEAAPGGVPALAAAVLGACEPRCAAPCPLPALSRCRAAGARGPRGAR
GGAGPPDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYIVRYMGCIEVLRSMRSLD
FNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASILGKSNLRFAGMSIAVSISTDGL
NLSVPATRQIIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSII
STVGQAFELRFKQYLHSPPRVAVPPERLTRPEESAWGDEDEADHNYYNSIPGKEPPPGGL
VDSRLALAQPGALGALGQGAAPARRDARSLPWDLGPSGAGPPGDGYVQADARGPRDYEDH
LYVNTQGLDAPEPPQAEDSPKKDLFDMRPFEDALKLHECSAGAGTAVAPLPVEDQWPSPP
TRRAPIAPTEEQLRQEPWYHGQMSRRAAEKLLRADGDFLVRDSVTNPGQYVLTGMHAGQP
KHLLLVDPEGVVRTKDVLFESISHLIDYHLQNGQPIVAAESELHLRGVVKREP

>Felis catus_SHC2(ENSFCAP_14316)
YMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGIRGSWKKKAPNKALASILGKTNLR
FAGMSIAVSISTDGLNLSVPATRQVIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRA
CHILECCEGLAQSIISTVGQAFELRFKQYLHSPPRVVLPPERLTRPEESAWGDEEETEHN
YYNSIPGKEPPLGGLVDSRLALTQPCAVGALGQGVSPARRDTRSLPWDLGPSGNSPPGDG
YVQADARGPRDYEDHLYVNTQGLDAPEPLQPEDSPKKDLFDMRPFEDALKLHECSAGAGA
AVAPLPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSRRAAEKLLRADGDFLVRDSVT
NPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDYHLQNGQPIVAAESELHL
RGVVKREP

>Pteropus vampyrus_SHC2(ENSPVAP_47)
YMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASILGKSNLR
FAGMSIAVSISTDGLNLSVPATRQIIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRA
CHILECCEGLAQSVISTVGQAFELRFKQYLHSPPKAVAPLERLTGLEESAWGDEEDTDHN
YYNSVPGKEPPLGGLVDSRLALTQPCALGGLGQGASPVRRDARGLQWEPGSSGTASAGDG
YVQADARGPRDYEDHLYVNTQGLDAPESLPPEDSPKKDLFDMRPFEDALKLHECSVAAGT
AAAPLPSEDQWPSPPTRRAPIAPTEEQLRQEPWYHGQMSRRAAEKLLRADGDFLVRDSVT
NPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDYHLQNGQPIVAAESELHL
RGVVKREP

>Xenopus tropicalis_SHC2(ENSXETP_14356)
MLAESRYDRFRNDSITSAEEQLALSAEAMSGQVAPSSPTGASALEPQYPEEQDVATTFCM
MIPRMGQWKFSSPTAFLSRSPSGANKELTVDKSGTGGGLGSVFGACDPVCSTPCTLQVIN
RLRGGGSGGARKSARTEAYKVQGEEWNRKGTFINKPAQGWLHPDDRLQGPGVSYIVRYMG
CIEVLRSMRSLDFNTRTQVTREAINRLYETVPGVRGTWKKKAPNKSLASILGRSNLRFAG
ISIAVNISTEGLNLSIPTSRQQVIANHHMQAISFASGGDADTTDYVAYVAKDPINQRACH
ILECCEGLAQSVISTVGQAFELRFKQFLHSPPKVAAPPDRLLVGTEEPAWGGEEEQEHNY
YNSIPGKEPPLGGLQDSRIREAGATGQLSTQININGQWSQVGSPARKPAVSHSCSQWDLE
DQAQASEGFPLTNGRAFGVRDYEEHMYVNTQNLDGLVADKEPYMIPEDSPKKDLFDMRPF
EDALKLHESSLSASQSLEDQWPSPPTRRAPVAPTEEQLRGEPWYQGKMSRREAEKLLQRD
GDFLVRDSITNPGQYVLTGMHKGQPKHLLLVDPEGVVRTKDVLFESISHLISYHLHNQQP
ILAAESELHLRQVVPRKV

>Danio rerio_SHC2(ENSDARP_114455)
MNRRTRVEGIWLGDNFTQKGSFINKPSQGWLHPDKKISSTGASYIVRYMGCIEVLKSMRS
LDFSTRTQVTREAINRLCESVPGGKTAWKKKTTNKTLQSIMGKSNLRFAGMSIGVNISID
GLSLLVPTTRQVIAHHPMQSISFASGGDSDTPDYVAYVAKDPVNQRACHILECCDGLAQN
VISTIGQAFELQFKQYLHSPPKAIPAMDSHAEYPNILSRNIRTEESAWGEDEESSEHDYY
NSIPGKEPPVGGVVDSRLRPPAGLLGHVHTHPQSKTSQMGSPAKRDANSLPATHLCYEVH
WDTENNRSSSLTSDGYLRADGHPPGSRDYEEHLYVNTQNLDNLEASVVGRRPESPKKDIF
DMRPFEDALRLHEASGVCVLEDKWPSPPRRRAPVAPTEDQLRREMWYHGRMSRRDAENLL
GRDGDFLVRDSATNPGQYVLTGMQCGLPKHLLLVDPEGVVRTKDMLFESISHLINYHLTN
KLPIVAAESELHLQQVVCRKI

>Takifugu rubripes_SHC2(ENSTRUP_23380)
MLLKPKYDRFRNESVTSSDDLMQSLAMSSKVVATPVVPSSAPSLPLPPLPPLDPGARSSL
IPKMPQWKFSNSLLSRSPSNTGSGSNSSKDSGKAAAAPSHAPVPPSSSSPQRSSTMSSAG
GPKGSFIHKPSQGWLHPDKKIAGPGASYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINR
LCEVVPGGRGAWRKKSTNKALQTVMGKSNLRFAGMSIAVNISIDGLSLLIPTTRQVIAHH
PMQSISFASGGDTDTPDYVAYVAKDPVNQRACHILECSDGLAQGVISTIGQAFELQFKQY
LHSPPKTLASVERSVRTEEPIWGEEESFSDHNYYNSIPGKEPPIGGVVDSRLRGVPQNCI
MRGQDTSEFLRRNQASYPSGQLCYELHWDTETTSSSGLTSDGYLCADGQSAGGKDYEEHQ
YVNTQNLDNLTSQGAEGPRAGRAPDSPLKDIFDMRPFEDALKLHEACAGAAGPTAAAAGG
TQVLEDQWPSPPRRRAPVAPNEEQLRREPWYHSRMSRRDAERLLIRDGDFLVRESTTNPG
QYVLTGMHCGLPKHLLLVDPEGVVRTKDMLFDSINHLIAYHLKNELPIVAAESELHLKQA
VRRKP

>Tetraodon nigroviridis_SHC2(ENSTNIP_18522)
LRAAPPGMLLKPKYDRFRNESVTSSDDLMQSLAMSSKVVATPVVPSSAPSLPLPPLDDAT
TTFCMLIPKMPQWKFSNSLLSRSPSNSSSGSSSSKDSGKAAAAPSQAPVAPTSSPQRNST
MSSAGGPVTRVEGMWLAGEDFTQKGSFIHKPSQGWLHPDKKIAGPGASYIVRYMGCIEVL
KSMRSLDFNTRTQVTREAINRLCEAVPGGRGAWRKKSMNKALQTVMGKSNLRFAGMSIAV
NISIDGLSLLIPTTRQQVIAHHPMQSISFASGGDTDTPDYVAYVAKDPVNQRACHILECS
DGLAQSVISTIGQAFELQFKQYLHSPPKSMASVERSARAEEPIWGEDEGFSDHDYYNSIP
GKEPPIGGVVDSRLRGSGAPLGHVHSQPLGCTAAQVTLQTDDVNGMGSPARRDQASYPPD
GQSAGSKDYEEHQYVNTQNLENLTSLGAEGPRGGRAPDSPKRDIFDMRPFEDALKLHPPR
RRAPVAPNEEQLRRETWYHSRMSRRDAERLLIRDGDFLVRESTTNLGQYVLTGMHCGLPK
HLLLVDPEGVVRTKDMLFDSISHLIAYHLKNELPIVAAESELHLKQAVRRKQ

>Gasterosteus aculeatus_SHC2(ENSGACP_15271)
MPQWKFSNSLLSRSPSNSSSSSGSSKDSGKAAAPQTSSSHSSSSHRHLAAVLTSCDPGCV
TPCSLQAMRGQRVVAASSGSRSGMNRRTRVEGMWLGGEDFTQKGGFIHKPSQGWLHPDKK
IAGPGASYVVRYMGCIEVLKSMRSLDFNTRTQVTREAINRLCDIVPGGKGAWRKKAQNKA
LQSVMGKSNLRFAGMSIAVNISIDGLSLLIPTTRQVIAHHPMQSISFASGGDTDTPDYVA
YVAKDPVNQRACHILECSDGLAQGVISTIGQAFELQFKQYLHSPPKTMASAERCARTEEA
MWAEDEDFSQHDYYNSIPGKEPPVGGLVDSRLRPSGALLGHIHTQPQSKTAAQQTGSPGR
REQASYPPGQLCYELHWDTETTGSSGLTSDGYLCADGQPPGSRDYEEHQYVNTQSLENLD
VLAQGPNGHRGSRAPESPKKDLFDMRPFEDALKLHEACGGPAAGAGVRVLEDQWPSPPRR
RAPVAPNEDQLRRETWYHSRMSRRDAEKLLVRDGDFLVRESTTNPGQYVLTGMHCGLPKH
LLLVDPEGVVRTKDMLFESISHLIAYHLKNELPIVAAESELHLKQVVRRKQ

>Oryzias latipes_SHC2(ENSORLP_21050)
MPQWKFSNSLLSRSPSNSSSSSNSSKDSGKAAGAPSQASSTLAAVLNSCDPVCVTPCSLQ
AIRGQRAVAAANSAAGAAEDFSHKGNFINKPSQGWLHPDKKIAGQGASYIVRYMGCIEVL
KSMRSLDFNTRTQVTREAINRLCEAVPGGRGVWRKKAFNKALQTVMGKSNLRFAGMSIAV
NISVDGLGLLIPTTRQVIAHHPMQSISFASGGDSDTPDYVAYVAKDPVNKRACHILECSD
GLAPSVISTIGQAFELQFKQYLHSPPKSMGSLERSVRPEEPVWGDDEDPSEHDYYNSIPG
KEPPIGGVVDSRLRPAGALLGHVHTQPPSKQAPQLHWDTDMTCSSGETPDGYLCADGQPT
GIKDYEEHQYVNTQSLEHLDAQGADGQRGPNDSPKKDLFDMRPFEDALKLHKACGGAGSQ
AGGGVVPILEDQWPSPPRRRAPVAPNEEQLRREPWYHSRMSRRDAEKLLVRDGDFLVRES
TTNPGQYVLTGMHCGLPKHLLLVDPEGVVRTKDMLFESISHLISYHLKNGLPIVAAESEL
HLKQVVRRKQ

>Homo sapiens_SHC3(ENSP_364995)
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ

>Gorilla gorilla_SHC3(ENSGGOP_12215)
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGKALRKAPDDG
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPMLSKAASVECISP
VSPTAPDAKMLEELQAKTWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ

>Macaca mulatta_SHC3(ENSMMUP_26786)
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPPAPRAPA
MSTARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGEGSDHPYYNSIPSKMPPPGGFLDARL
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQAPFRQNERQGSLDIYSMPEGKLHVA
PTGEAPTYVNTQQIPPQAWPTVVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVE
CISPVSPRAPDAKMLEDLQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGM
HNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ

>Mus musculus_SHC3(ENSMUSP_21898)
MSATRKSRAGDEPLPRPPRGAPHTSDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQV
TREAISRVCEAVPGAKGALKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPSKVPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPTKMPPPGGFLDARL
KGRPHAPEAAQFAGKEQTYYQGRHLGDTFGEDWQRAPTRQGSLDIYSTAEGKTHMVPVGE
TPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPMLSKAASVECISP
VTPRAPDARMLEELNAEPWYQGEMSRKEAEALLREDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTIRTKDRVFDSISHLINYHLESSLPIVSAGSELCLQQPVERKP

>Rattus norvegicus_SHC3(ENSRNOP_19442)
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGGKVSAEPAASPYLVSGEALRKAPDDGPGS
LGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGGSATPGSRAPAAS
MSATRKSRASDEPLPRPPRGAPHASDQVLGSGVTYVVKYLGCIEVLRSMRSLDFSTRTQV
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
FELRFKQYLQCPSKIPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPNKMPPPGGFLDARL
KARPHAPDAAQFSGKEQTYYQGRHLGDAFGEDWQRAPTRQGSLDIYSTPEGKAHMVPVGE
TPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPVLSKAASVECISP
VTPRAPDAKMLEELNAEPWYQGEMSRKEAEALLQEDGDFLVRKSTTNPGSFVLTGMHNGQ
AKHLLLVDPEGTVRTKDRVFDSISHLITYHLESSLPIVSAGSELCLRQPVERKP

>Canis familiaris_SHC3(ENSCAFP_3204)
MRSLDFSTRTQITREAISRVCEAVPGTKGAFRKRKPPSKMLSSILGKSNLQFAGMSISLT
ISTASLNLRTPDSKQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDG
LAQDVIGSIGQAFELRFKQYLQCPSKVPAFHDRMQSLDEPWTEEEGDGSDHPYYNSIPSK
TPPPGGFVDVRLHARPHAPDTAQFAGKEQTYYQGRHLGDPFGEDWQQTPVRQGSLDIYST
PEARVPAAPGEAPTYVNAQHIPVQATPASGSSTESSPLKDLFDMKPFEDALRNQSLGPVL
SKAASVECISPVTPRAPDAKMLEELEGEPWYQGEMSRKEAEGLLKNDGDFLVRKSATNPG
SFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLENSLPIVSAGSELCLQQP
VEKTL

>Myotis lucifugus_SHC3(ENSMLUP_6051)
MLPRTKYNHFKKDSVTSVDDLLHLSVSGGSKVSAARAAPAAAAPYLVSGDALRRAPDDGS
GSRGHLLHKVSHLKLASSGLRGLSAARERAGARLSGSCSAPSLAAPDGSAPPGPRAPAMR
AARKGRPGEEPPPSAPPASDQVLGAGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAIS
RVCEAVPGAKGAFRKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTSDSKQIIA
NHHMQSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGAIGQAFELRFK
QYLRCPSKVPALHDRMQSLDEPWTEEEGAGSDHPYYNSIPNKAPPAGGVDARLKARPHGP
DSAPFSGKEQTYYQGRHVGEPFGEDWQQTPARQGSLDTSSMPGGTAPAAPTGEAPTYMNT
PHFPPQAGPAAGSSAESSPRKDLFDMKPFEDALKNQPVGPVLSKAASVECISPVSPRAPD
AKMLEELKAELWYQGQMSRKEAEGLLKRDGDFLVRKSTTNPGSFVLTGMHDGQAKHLLLV
DPEGTIRTRDRIFDSISHLINHHLANRLPIVSAGSELCLQQPVERNP

>Pteropus vampyrus_SHC3(ENSPVAP_3507)
RKADDGPGSLGQLLHKVSHKLSSSGLRGLSAARERAGARLSGSCSAPSLAAPDGSAPPGP
RAPAMRASRKGRPGDEPPPRASPASDQVLGAGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
TREAISRVCEAVPGAKGAFRKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
SKQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVISSIGQA
FELRFKQYLQCPSKISAFHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKTPPPGGFVDARL
KVRSHVPDTAQFAGKEQTYYQGRHLGELFGEDWQQTPIRQGSVDIYSMPEGKAHVAPTGE
APTYVNTQHFPLQAGPSASSSAESSPRKDLFDMKPFEDALKNQSIGPVLSKAASVECISP
ISPRAPDAKMLEELKAEPWYQGEMSRKEAEGLLKRDGDFLVRKSTTNLGSFVLTGMHDGQ
AKHLLLVDPEGTIRTKDRIFDSISHLINHHLENSLPIVSAGSELCLQQPVERNL

>Gallus gallus_SHC3(ENSGALP_17365)
MLQRTKYNRFRNDSVTSVNDLIHNLSMNSKVSAAATASAASSYLVTPEVLRKDQEDGPTT
LCTLIHKVSHLKFSNAGSLLGIKNLSSAVKELAVSKLQGSSSASSSAAEASDNACNLVSA
TSCSQQDISKMSVGKKARSEEMHPGDEDWNQRSSIVDKPSQGWLHLSEKILGPGVTYIVK
YLGCIEVLRSMRSLDFNTRTQITREAISRVCEAVPGAKGAFKKRKPPSKVLSSILGKSNL
QFAGISIMLNISTTSLNLMTPDMKQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNRR
ACHILECCNGLAQDVISTIGQAFELRFKQYLQCPSKMPTFHDRMQSFDEPLMEEESAAAE
HPYYNNIPNKMPPPGGFINARLKAKIPTAADTAQFAAGVRREKIYYQNRHLGDKFNEDWH
EETVKQGPLDIYSMPEGKSEATARAEMPMYVNAQHINMETLLALQADAESDISGNTDSTK
ESSPEKDLFDMKLEPFEDALKNQTSEPVLSKLTSVECTSPLLCRAADWTRTEDLSIEPWY
QGEMSRKEAEQLLKKCGDFLVRKSTTNPGSYVLTGMQNGQAKHLLLVDPEGTVRTKDRVF
DSISHLINHHLENNLPIVSSGSKLCLQQPAERKH

>Xenopus tropicalis_SHC3(ENSXETP_16941)
MLQRTKYNRFKNESVTPVDDLLHNLSMNSKVTTVAGNPASPPCSAPPDVLQKDQENGPTT
LCTFIHKVSNLKLSSSGSLLGIKNLSSAVKELTGSKLQGSSPALSIAAGATENTCNLVST
PCSQQDLNKMSTGKKTPEEMHQGGEDWNQSSSFVNKPSRGWLHSNEKILGPGVTYIVKYL
GCIEVLRSMRSLDFNTRTQITREAFNRVCEAVPGTKGVFKKRKPANKNLSSILGKSNLQF
AGMSITLNISTTSLNMMTPDTKQIIANHHMQSISFASGGDPDATDYVAYVAKDPVNRRAC
HILECCDGLAQDVISTIGQAFELRFKQYLQCPSKIPVFPDRMQSLDDPLWQEEDGMTTEH
QYYNSIPNKMPPPGGIIDERLKTHISNQGDNTQSVPLEQSYYQGRHLVEKSCENFQQTVK
RQASLDIYSLPEGKSSINQTSNAPTYVNTQHINKKTLGAIQKSADSILCKSVDSSRDISP
RKDIFDMKPFEDALKNQPVLSKDASVDCSSPLLSRAAILTINEELRSEPWYVGEMCRREA
EKLLKRDGDFLVRKSINNPGSYVLTGMHNGLAKHLLLVDPEGTVRTKDRVFDSIGHLINH
HLENNLPIVSSGSELCLKQPMEGKP

>Danio rerio_SHC3(ENSDARP_139836)
MLHRAKYNRFRNESVTSVDELLHGLSMNAKVSAVPPSPPVGDPPYAPPADPDPAEESGTL
CTLINKVSNLKFTNSSGLLGIKGLPSAVKDLAVSKLQGGAAAGASSSPASSTLAAASPLE
PGSTSSGKKGRMEESQPSGEGWSLGGTGAAGCGGLVNKPSHGWLHSSEKISGPGVTYVVK
YLGCIEVLRSMRSLDFTTRSQITRGLFNILLQMTTGSDGEVINGDETPSKLLSSILGKSN
LQFAGMSINLNISTSSLNLMTPDSKQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNR
RACHILECSDGLAQDVISTIGQAFDLRFQLYLQCPSSKPSSIHDRVMSTDEPPWTEEGDE
TADHHYYNSIPGKMPPPGGFIDARLTNQSQDSSQGAGVDQTYYQGRPMFIQQEKTFNCMF
NNKRSCDIYSLPEVKAQPPKAGEVPTYVNTQHIDTQVLAALQAETETNADSSTTGAPKDS
PRKDLFDMKPFEDAIMTQTPAASELHKAASVDNSSPLLMRAAALRAHEELEDQRWYHGEM
SRRQAEKLLLHDGDFLVRKSTTNPGSYVLTGMHNGLAKHLLLVDPEGTVRTKDHIFESIS
HLIGHHRDNNLPIVSAGSELCLKQPVDRKQ

>Takifugu rubripes_SHC3(ENSTRUP_26154)
MLHRTKYNRFRNESVTSVDELLHGLPMNPKVSASPETSYTPPTEVQSFSTATASSTPACL
GSDHLEDGGTTLCTLINKVSGLKFSNSGSLLGIKGLPSAVKDLAVSKLQAASSSGGSACG
SHSVPCSQLEPAVGMSKKSRLDELQLGKPSRGWVHSSDKISGPGVTYIVKYLGCIEVLRS
MRSLDFTTRSQITREAISLVCEAVPGTKGALRKRKPPSKTLSSILGKSNLQFAGMSINLN
ISTSSLNLMTPDGKQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNRRACHILECSDG
LAQDVIGTIGQAFDLRFQQYLQCPSSKISSPHDRVLNMEELTWTEEEEESTEHPYYNNIP
GKMPPPGGIVDTRLTNQNAAQDGCQMGPGSIDQTYYQGRHCGENWGDDRKPIFIQQGSFD
IISLPESKGQAQRAEMPAYVNTQQIDAQVLAALQAEGENVTKGLASAPAKESPQKDLFDM
KPFEDAIQSEGPEHSQAAGLHKAASVDNASPLLVRSLAFRAQEELEGQTWYHGIMSRREA
EKLLQDDGDFLVRKSTTNPGSYVLTGMHNGLAKHLLLVDPEGTVRTKDHVFDSILHLIGH
HRDNNLPILSAGSELFLLQPVGRKQ

>Tetraodon nigroviridis_SHC3(ENSTNIP_21940)
MLHRTKYNRFRNESVTSVDELLHGLPMNPKVSASPETSYTPTAEVQSSSTTTASSTPASL
GSNHLEDGGTTLCTLINKVSGLKFSNSGSLLGIKGLPSAVKDLAVSKLQVGGGSGSCGSG
SPSPCGRLRVRPPRSPLLTAGAGRRHEQESVSKPSRGWLHSSDKISGPGVTYIVKYLGCI
EVLRSMRSLDFTTRSQITREAISLVCEALPGTKGALRKRKPPSKTLSSILGKSNLQFAGM
SINLNISTNSLNLMTPDGKQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNRRACHIL
ECSDGLAQDVISTIGQAFDLRFQQYLQCPSGKISSPHDRVLNMEELTWTEEEEESAEHPY
YNNIPGKMPPPGGIIDTRLTSQNTAQDGCQMGPGSIDQTYYQGRHCAENWGDDRKPVFIQ
QGSFDVISLPESKVQAQKVEMPAYVNTQQIDAQVLAALQAEAKESPQKDLFDMTEPFEDA
IHSQGPEPSQAAALSKAASVDNASPLLVRSLAFRAQEELEGQEWYHGIMSRREAEKLLRD
DGDFLVRKSTTNPGSYVLTGLHNGLAKHLLLVDPEGTVRTKDHVFDSILHLIGHHRDNNL
PILSAGSELFLLQPVGRKQ

>Gasterosteus aculeatus_SHC3(ENSGACP_21815)
MLHRTKYNRFRNESVTSVDELLHGLSMNPKVSATPQSAAETSYTPPTEVQPSAAAACSIS
TGHGSDHLEDGGTTLCTLINKVSGLKFSNSGSLLGIKGLPSAVKDLAASKLQGGGGLGSG
GGGGGGGGVPAAATSGDWNPGGGGGGLVIKPSRGWLHSSEKISGPGVTYVVKYLGCIEVL
CSMRSLDFTTRSQITREAISLVCEAVPGTKGALRKRKPPSKALSSILGKSNLQFAGMSIN
LNISTSSLNLMTPDCKQIIANHHMQSISFASGGDPDTTDFVAYVAKDPVNRRACHILECS
DGLAQDVIRTIGQAFDLRFQQYLQCPSGKLSSTHDRVLNMEELPWTEEEEESAEHPYYNN
IPGKMPPPGGFIDTRLTTQNAAADGCGVQLLDQTYYQGRHCGENWGDERKVIFIQQGSFD
ISGLPESKGQAPKTGEMPAYVNTQQIDAQVLAALQAEAEHCPQKDLFDMKPFEDAIQSQS
HPPSQPQVAAIHKTASVDNCSPLLARSVAFRAQEELQGQMWYHGQMSRRDAEKLLKEDGD
FLVRTSTTNPGSDVLTGMHNGLAKHLLLVDPEGTVRARRA

>Oryzias latipes_SHC3(ENSORLP_7238)
MLHRTKYNRFRNESVTSVDELLHGLSMNPKVSATPHSAAETPYTPPTEVQSSSGTPLSNA
PTSHGSDHLEDGGTTLCTLINKVSNLKFSNSGSLLGIKGLPSAVKDLAVSKLQGGGGSGS
SSGSSPSAATAAAASVPCSQQEPALSMSKKSRLDELLPSGEDWNPGGGGGLVSKPSRGWL
HSNEKISGPGVTYIVKYLGCIEVLRSMRSLDFTTRSQITREAISLVCEAVPGTKGALRKK
KPPSKALSNILGKSNLQFAGMSINLNISTSSLNLMTPDCKQIIANHHMQSISFASGGDPD
TTDFVAYVAKDPVNRRACHILECADGLAQDVISTIGQAFDLRFQQYLQCPSNKPSSTHDR
ILNMEELPWTEEEEESTDHPYYNNIPGKMPPPGGFIDTRLTNQNAASEGSQVCGKMATGS
VDQMYYQGRHCEGWAEERRPIIIQQGLGSFDIVGFPESKSQAAKTGEMPTYVNTQQIDAQ
VLAALQAEAENVMKGMAATTKDSPQMDLFDMKPFEDAIQSHPPSQGQTQTPVSNLHKAAS
VDNSSPLLVRSLAFRAQEELEDQTWYHGKTSRRDAEKLLKQDGDFLVRKSTTNPGSYVLT
GMHSGLAKHLLLVDPEGTVRTKDHIFDSISHLIGHHRDNNLPIVSAGSELCLLQPVARKQ

>Homo sapiens_SHC4(ENSP_329668)
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH
PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ
ESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRH
FLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV
HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC
SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN
QRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
SLPIISSGSEVSLKQPVRKDNNPALLHSNK

>Gorilla gorilla_SHC4(ENSGGOP_10158)
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH
PALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ
ESRDPGSSGPSSPETSLSRSGTAPPPQQDFVGHRATALTPDSCALPGPGEPTLRSRQDRH
FLQHLLGMGMNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV
HIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKC
SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGN
QSSVQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
SLPIISSGSEVSLKQPVRKDNNPALLHSNK

>Macaca mulatta_SHC4(ENSMMUP_12873)
MRERSQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPH
PALAPHLPAEDAALPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQ
ESRDPGSSSPSSPETSLSRSGTAPPPQPDLVSHRATALTPDSCPLPGPGEPPLRSRQDRH
FLQHLLGMGMNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECHNGMAQDVINTIGQAFELRFKQYLKNPSLDTSCESEEV
RIDSHAEESEDHEYYNEIPGKQPPAGGVSDMRIKVQATEQMAYCPIRCEKLCYLPGNSKC
SSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTLGSAGN
QSSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLL
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
SLPIISSGSEVSLKQPVRKDNNPALLHSNK

>Canis familiaris_SHC4(ENSCAFP_21819)
MRRRGRDSLAGLVLCVGLVGHPGMLHRAKYSRFRNESVTSLDESGPGGGAGGDKGSPQPP
YPALAPHLPPEDATLAAQESPTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKL
QESQDPAPSSPAPPEAGLTRAGPAPLPQQPGPVGHRATVLTPEACPLPGAGQPTPGSRQD
RHFLQHLLGMGMNYYVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVSGANGAVKK
RKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNIDNQQIIANHHMQSISFASGGDP
DTTDYVAYVAKDPVNQRACHILECRSGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESE
GVPIDDHAEEREDHEYYNEIPGKQPPAGGVSDVRIKVQATEQMAYCPIRCEKLCYLPGNS
KCSSVYENCLEQSRAIGNAQERGVQSHRDASLMKHACRVDFFNDPCYINTQAFQSTLGSA
PNQSSAHVLGSPWHREKAPETVQPGATAQPASSHSLPHVKQQLRSEDCYHGKLSRKAAES
LLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHM
DNSLPIISSGSEVSLKQPVRKDNNPGLLHSNK

>Felis catus_SHC4(ENSFCAP_20059)
MRKRGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDESSPGGSVGSKGSAPPPY
PTLAPHLPAEDATLASQESPTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQ
ESQDPAPSSPASPETSPNRAGSAPLPQPDLLGHRAAALTPDACPLPGPGEPTPGSRQDRH
FLQHLLGMGMNYYVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVSGANGAVKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNIDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECRSGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEV
PLDGPAVEREDHEYYNEIPGKQPPAGGVSDVRIKDQATEQMAYCPIRCEKLCYLPGNSKC
SSVYENCLEQSRAIGNAQERGGQCQRDAALMKHTCRVDFLNDPCYINTQGLQSTLGSSPN
QSSAHSLGSPWHRQKAPETVQPGATAQPASSHSLPHIKQQLRNEDCYHGKLSRKAAESLL
VKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDN
SLPIISSGSEVSLKQPVRKDNNPGLLHSNK

>Myotis lucifugus_SHC4(ENSMLUP_11751)
MRERSPDGLAGLALHVGLFGHPGMLHRAKYSRFRNESVTSLDEGSPGGSVGNKGSPQPPY
PALAPHLLAEDAPSPSQESPTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQ
ESQDPAPSSPASPENSLNRSGSAPPQQRDVVGRRASALTPDACPLPGPGDPTPGSRQDRH
FLQHLLGMGMNYCVKYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGATKKRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNHQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECRNGMAQDVITTIGQAFELRFKQYLKNPSLNTSCESEEV
HIDGHADERDDHEYYNEIPGKQPPMGGVSDVRVRVQATEQMAYCPIRCEKLCYLPGNSDC
SSVYENCLEQSRAIGNAHERAVPSQRDTALMKHTCRVDLFDDPCYINTQALHSALGSTRN
PGSAQLLGSLWHREKAPETVQPGATAQPASSRSLPYIQQQLRSEDCYHGKLSRKAAENLL
VKDGDFLVRESATSPGQYVLSGLQGGQKHLLLVDPEGKVRTKDHIFDNVGHLIRYHMDNS
LPIISSGSEVSLKQPVRRDNIPGLLHLNK

>Pteropus vampyrus_SHC4(ENSPVAP_11141)
MRERSQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSPGGSVGNKSSPQPPY
PALAPHLPAEDATLASQESPTPLCTLIPRMASVKLANPATLLSLKNFCLGTKEVPRLKLQ
ESQDLAPSNRASPEPSQNRAGSAPPSQQDVVGHRPTALTPDVCPLPGPGEPTPGNRQDRN
FLQHLLGMGMNYYVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKRRK
PPVKFLSTVLGKSNLQFSGMNIKLTISTYSLTLMNLDNQQIIANHHMQSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECRNGMAQDVITTIGQAFELRFKQYLKNSSLNTSCESEEV
HIDGHAEERDHEYYNEIPGKQPPAGGVSDVRIKVQAAEQMAYCPIRCEKLCYLPGNSKCS
SVYENCLEQSRAIGNAHEREVQYQRDTSLMKHTCRVDLFDDPCYINTQALQSTLGSARNQ
SSDHSLGSPWHREKAPETVQPGAMAQPASSHSLPHIKQQLRNEECYHGKLSRKAAESLLV
KDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNS
LPIISSGSEVSLKQPVRKDNNPGLLHSNK

>Gallus gallus_SHC4(ENSGALP_8011)
MRERGPQSLGAHVLYVGLLRHPGMLHRAKYSRFRNDSVTSLDEGPQNIKGSSSSSHPSAP
NLLAEDVPLGPQDACTTLCALIPRVANIKLANPSALPSLKGFCLGSKEVPRTKLTECVAV
PGGPSSPELGCLSASYPQPGPEGPHLTPRPAGGCTGRGAAEAVSRLGGSLVPSGESAEEP
GTTYSVRYMGCIEVLQSMRSLDFGTRTQVTREAISRLCEAVSGTNGAIRKRKPPVKFLSS
VLGKSNLQFSGVNIKLTISTNSLTLINVDTQQIIANHHMQSISFASGGDPDTTDYVAYVA
KDPVNQRACHILECPNGMAQEVINTIGQAFELRFKQYLKNPSSLVTSNESEAVSADGSAG
NLQEREDHEYYNEIPGKEPPAGGVLDMRMKVPTDQRSGCFIQCKKQHCLTGSPTFINIYE
NCPEENKTVGPCAERSQKTKKDATLLKSAYRTDLFDDPCYINTQALQSAVCTARGTAATQ
IHGSPRSHTKLPETVQQSATSNTAGLCVLPQIKQQLRNEDCYHGKLNRKAAESLLVNDGD
FLVRESTTSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDRIFDSVGHLIQYHMENNLPII
SSGSEVSLKQPVRKESNMGHLHYHK

>Pelodiscus sinensis_SHC4(ENSPSIP_12922)
MRERSQHSLSGHALYVGLFRHPGMLHRAKYSRFRDDSITSLEEGTQNSSLNIKGSSSSSL
SSTPHLPIEDVNLGTQDSSTTLCTLIPRMANIKLSNPSNLPGLKNFCLGTKEVPRIKLTE
CVTVPGSPTSPEISLLSCLPASYPRQDPEKLDVNTKSQDDCVLLGFESASLSKQDSPLVQ
SGEGIVKTGMTYCVRYMGCIEVLQSMRSLDFGTRTQVTREAISRLCEAVSGTNGAIKKRK
PPVKFLSSVLGKSNLQFSGMNIKLIISMSSLTLMNVDNQQIIANHHMHSISFASGGDPDT
TDYVAYVAKDPVNQRACHILECPNGMAQSVINTIGQAFELRFKQYLKNPSTLITSNESEV
MNLDGSAWNIQEREDHDYYNEIPGKEPPTGGLLDMRMKVQMDQRANCPIQCEKQYGLAGS
PKCINIYENCPEENKSVGNCGERSLKAKKDVSLLKPACKMDLFDDPCYINTQTLQTTAYT
ARGLASAQVYGSPLCHEKLTEAVQQHATTNMDSACVLSQIKQQLRNEDCYHGKLNRKAAE
TLLVNDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDSVGHLIRYH
MENNLPIISSGSEVSLKQPVRKKSNIGHMQYNK

>Ciona intestinalis _(ENSCINP_13182)
MRRNKKLVEGDQTNEWRKSGSFVNKPQRGWLHPDSSVMGPGVVYSVQYLGCVEVRQSMRT
LDFDMRTLATKEAIWRVLASTGMSPLPPAANRSGRKKPPKDVTRILGERPNLKFSQSFIN
LTISTASLTLVVSNTGQFIANHQMQSISFASGGDPDTIDYVAYVAKDPINSRACHVLKCT
DGLAQDVINTIGQAFELRFKEYLKNPPKAVTPPDRTEPLFHDGKSRWGDDEPEYYNEIPG
KLAPESGLKRLDDGSKIDEGAVVYPNHHNSQEYINNGMQSECSAPTPTLSTPTPRRTPRN
FEDHNYVNTCVMPHGQEPTNQKRPSVDAFDMRPFANTLNPPATPTSATNALQSKPWFHGH
VTRKEAEQLLSHDGDFLVRESTTTKGQFVLSGVQDGQYKHLLLVDPNGVVRTKDRQFDSV
SHLISFHRDNTLPIVSSGSVLLLRQPVTRQIER

>Branchiostoma floridae _(XP_002608644)
MVATTTWAGITGFPLTFKRKATWEVLSTPGGDGVSPCTTSAHAFLSDMTAARSSSASPVSLESSLGKETQ
DYVAYVAKDXVNSRACHVLHCPGGLAQDVITTIGQAFELRFKDFLKNPPKAVSAPDRLEDPIFEEGESAW
GDDPEYYNEIPGKLPPTGGMPPPLPAGPPPGHYQAPSNLQASDGVYSSVKDAPSRPGPTYDNKASADNLI
DFTAETPTAPVYDNPLHEPAGRGPPVSHGNDLPPEAAQPRSEVSLFDDPTYDNRRIENRPMHPDPMGAQQ
PPQQPPQRPPLPLPAQDPFNMGPFDAGLQQDPASPPHPLYQEEWFHGPMTRKQAEELLEEDGDFLVRESE
RKYDITGPVVLTCLCLCAGERKYNITGPVVLTCLCLCAGERKYDITGPVVLTCLCLCAGERKYDITGPVV
LTACWRQSQTPATGGPTGHKLE

>Apis mellifera _(XP_395635)
MATGGSSFISKPARGWLHPDHLVSKEGITYTVKYIGCLEVYTSMKSLDFETRSCVAKECINRVCEAAGLK
SADKKRRVDRKVLRAIADKPRMEHTGATINLTISSCSLALTNIENGHIIAKHEMPRISFASGGDTEILDF
VAYVAKNMQEWRACYVLECGGGLAQDVISTIGQAFELRFKEFLTKPASLHPILNGIREADRDYYNDLPGK
VPPDIGPPPVPPLPTSASTLPNLKHHHSVQNHISRSNIQNSGLHDTFSISSDRHHQQWAETGNLIDLNSD
GTSTNFNIPPEHNYVNDSVIAASRENQRDQTSLFDVFDMQPFSSAISDMNKLSPHSQKQQLKQEIWFHGS
VSRAEAESMLTRDGDFLVRESQGSPGQYVLTGMNNNTPKHLLLIDPEGVVRTKDRVFDSVSHLVNHHCDN
VLPIISADSVLVLRYPIPRRTNN

>Caenorhabditis elegans _(F54A5)
MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA
AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT
ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP
PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP
GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS
LNLIRPVPCPGSDDIE

>Anopheles gambiae _(XP_317844)
MPRNGEASSGLEKGVSSSKTAPEWLHPDHVIMNEGVTFDVRYIGCLEIKASMKKLDFPTRSQVAKECINR
VCEAASLKSSKKRRVDKRVLQCISDTPDMEHAGTNVTLTVSSKYLSLVNVDTGEIIAKHDMPRISFASGG
DTDTLDFVAYVAKDLNEWRACYVLECGGSLTQDLIATVGQAFELRYKEFFKQPETQSKFHELTRTDKVYY
NDLPDKMPPDLLTENDHHSSSQSHSSSSAKVDAVQGQTRERIPSNLIDLNTPLPCHDYVNDKHANATNNS
HSNKSISSSTIVKDVFDMRKSQLLTESWYHGSISRAQSEHLLKNDGDFLVRESAGTQGQYVLTGMQNNSP
KHLLLIDPEGIVRTKDRVFDSISHLINFHWTNSLPIISAESALLLRHPILRTTDLLSKAKLAHLNLQ