>Homo sapiens S1PR1
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS

>Pan troglodytes S1PR1
MGSTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKETLLANSSDPSSPAWNSAAANRTIPPTPRRTMGTTQRPLCLLET
STLLPRTGSCPPTGSALYLVAGHPSVWKKISGLRLLPGRSCCKPEGGRGRIRTAWWCRVL
VGRVSSCEQCTGKGGDQVPAWNIFSTPLEL

>Gorilla gorilla S1PR1
MGSTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Pongo abelii S1PR1
MGSTGVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Macaca mulatta S1PR1
MGSTSVPLVKALRSSVSDYVNYDIIVRHYNYTGKLNTSADRENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALPSCSTVLPLYHKHYILFCTVFIACWAPLFILLLLDVGCKVKTCDILFRAEYF
LVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSD
NSSHPQKDDGDNPETIMSSGNVNSSS

>Callithrix jacchus S1PR1
MGSTSVPQVKAPRSPISDYVNYDIIVLHYNYTGKLNTSADKDIKLTSVVFILICCFIILE
NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREG
SMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGW
NCISTLPSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIS
KASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVL
NSGSNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKIKRPIIAGMEFSRSKSDNSSHPQ
KDDGDNPETIMSSGNVNSSS

>Mus musculus S1PR1
MVSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIM
GWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Rattus norvegicus S1PR1
MVSSTSIPVVKALRSQVSDYGNYDIIVRHYNYTGKLNIGVEKDHGIKLTSVVFILICCLI
ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFL
REGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPI
MGWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRK
NISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVL
AVLNSGTNPIIYTLTNKEMRRAFIRIISCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSS
HPQKDDGDNPETIMSSGNVNSSS

>Oryctolagus cuniculus S1PR1
MGPTNIPLVKALRNSVSDYVNYDIIVRHYNYTGKLNISADKENGIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIM
GWNCISTLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFKAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGVEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Canis familiaris S1PR1
MGSTSVPLVKALRSPVSDYVNYDIIVRHYNYTGKLNTSADKENGIKMSSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLVLGGLPIM
GWNCIGALASCSTVLPLYHKHYILFCTTVFTLLLLAIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRILSCCKCPGGDPAGKFKRPIIAGVEFSRTSLSMVAE
ICLKKSSLSTVWYPAGSLVSQEEQTSKTR

>Felis catus S1PR1
MGSTSVPLVKTHRSSVSDYVNYDIIVRHYNYTGKLNVSADENGIKLSSVVFILICCFIIL
ENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLRE
GSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGFPIMG
WNCINMLASCSTVLPLYHKHYILFCTTVFTLLLLAIVILYCRIYSLVRTRSRRLTFRKNI
SKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAV
LNSGTNPIIYTLTNKEMRRAFIRILSCCKCPSEDSAGKFKRPIIAGMEFSRSKSDNSSHP
QKDDGDNPETIMSSGNVNSSS

>Bos taurus S1PR1
MGSTRIPLVKALHSPVSDYVNYDIIVRHYNYTGKLKISADKDNGIKLISVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNRFRSFLLISACWVISLILGGLPIM
GWNCISTLPSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLGVFIACWAPLFILLLLDVGCKVKTCDILFRTEYFLVLA
VLNSGTNPIIYTLSNKEMRRAFVRIMSCCKCPSRDSASKFTRPIIAGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Equus caballus S1PR1
MGSTSIPLVKALRSSVSDYVNYDIIVRHYNYTGKLNISVDKENGIRLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIM
GWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSTGKFKRPIIAGVEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Dasypus novemcinctus S1PR1
MGSTSVPLSKTLRTSISDYGNYDIIVRHYNYTGKLNLSADKDKGIKLTSVVFILICCCII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIM
GWNCIGVLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
VSKASRSSEKSLALLKTVIIVLSAFIACWAPLFILLLLDVGCKVKTCDILYRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDATGKIKRPIMAGMEFSRSKSDNSSH
PQRDDGDNPETILSSGNVNSSS

>Myotis lucifugus S1PR1
KAPDAGRAMGSTSSALSDYSNYDIIIRHYNYTGKLNLGQDKDSGLKVTSAVFILICCCII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYIMNLLFSGANTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHHESSSSRSFLLISACWVISLVLGGLPIM
GWNCLGLLPSCSTVLPLYHKHYILFCTTVFTVLLLSIVILYCRIYSLVRTRSRRLTFRKN
ASKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVRTCDILFKAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCRCPSTDTPGKFKRPIIAGVEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Pteropus vampyrus S1PR1
MGSTSIPLVKALRSPVSDYVNYDIIVRHYNYTGKLNLGTDKDSSIKVTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYAVNLLFSGANTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNESNSSRSFLLISACWIISLILGGLPIM
GWNCISMLPSCSTVLPLYHKHYILFCTTVFTVLLLSIVILYCRIYSLVRTRSRRLTFRKN
TSKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFKVEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIKIMSCCKCPRGDTTGKFKRPIIAGVEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Monodelphis domestica S1PR1
TMGSTSVPSVKAFPSSVSDYVNYDIIVKHYNYTGKLNSSAEGGLKVTSVLFILICCFIIL
ENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLRE
GSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIMG
WNCIGYLHSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNI
SKASRSSEKSLALLKTVIIVLSAFIACWSPLFILLLLDVGCKVNTCKILYKAEYFLVLAV
LNSATNPIIYTLTNKEMRRAFVRIMSCCKCPSRDSGAKFKRPIIGGMEFSRSKSDNSSHP
QKDDGDNPETIMSSGNVNSSS

>Erinaceus europaeus S1PR1
MGSTSLPVVKALRSSVSDYVNYDIIIRHYNYTGKLNISVDKENVIKPTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGLPIM
GWNCIGALPSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILYRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSTGKFKRPIIAGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Ornithorhynchus anatinus S1PR1
AMGSPGSPYPKPGAVPDYVNYDIIIRHYNYTGKLNPGAESQLKLTSVLFIVICCFIILEN
IFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYMANLLLSGATTYTLTPAQWFLREGS
MFVALSASVFSLLAIAIERYITMFKMKLHNGSNSVRSFLLISGCWVVSLVLGGLPIMGWN
CINELQSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCLIYSLVKTRSRRLTFRKNASK
ASRSSEKSLALLKTVIIVLSAFIACWAPLFILLLLDVGCKVKTCSILFKAEYFLVLAVLN
SATNPIIYTLTNKEMRRAFTRIICCCKCPPADSGGKVKWPIVGGMEVSRSKSDNSSHPQK
DEGDCPETIMSSGNVNSSS

>Gallus gallus S1PR1
MSSGTTAPVRVVSSLTNTDVNYVIKEHYNYTGKLNENADSGIKVTSVVFIIICCFIILEN
IFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGHKTYSLTPSQWFVREGS
MFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISVILGGLPIMGWN
CISLLSNCSTVLPLYHKHYILFCTTVFTGLLLSIVVLYCRIYSMVRTRSRRLTFRKNITK
ATRSSEKSLALLKTVIIVLSAFIACWAPLFILLLLDVGCRVKTCPILYKAEYFLVLAVLN
SATNPIIYTLTNKEMRRAFIKILCCCKCPPTDSGTKFKRPIIGGMEFSRSKSDNSSHPQK
EEGDRPETIMSSGNVTSSS

>Taeniopygia guttata S1PR1
VNYVIKEHYNYTGKLNESVDTGIKVTSVVFIIICCFIILENIFVLLTIWKTKKFHRPMYY
FIGNLALSDLLAGVAYTANILLSGHKTYSLTPNQWFVREGTMFVALSASVFSLLAIAIER
YITMLKMKLHNGSNSFRSFLLISACWVISTILGGLPIMGWNCKNLLSNCSTVLPLYHKHY
ILFCTTVFTGLLLSIVVLYCRIYSMVRTRSRRLTFRKNITKATRSSEKSLALLKTVIIVL
SVFIACWAPLFILLLLDVGCKVKTCPILYKAEYFLVLAVLNSATNPIIYTLTNKEMRRAF
IKILCCCTCPPADSGTKFKRPIIGGMEFSRSKSDNSSHPQKEDGDHPETIMSSGNVTSSS

>Anolis carolinensis S1PR1
MEELYEKGLCRSIGVSNFLIDHLEQLKEDCQITPHVNQVEYHPFQRPQELVNYCRRRNIV
FEGYCPLAKGEALSHPNIIQLAKKYARTPAQICIRWSIQNGIVTIPKSTKPERIQENCQD
SGFCGYPEGGRRWSSRHLDVADQAAGEISTPRCFLTSFWRTAIQAGTMDTTRDPRMKDTP
RVSDYVNYDIIIKHYNFTGKLNENADTEIKVSSVVFILICCFIILENIFVLLTIWKTKKF
HRPMYYFIGNLALSDLLAGVAYTANILLSGHKTYTLTPVQWFLREGSMFVALSASVFSLL
AIAIERYITMLKMKLHNGSNSFRCFLLISACWVVSVILGGLPIMGWNCIGSLKRCSTVLP
LYHKHYILFCTTVFTGLLLSIVVLYCRIYILVRTRSRRLTFRKNAAKATRSSEKSLALLK
TVIIVLSVFIICWSPLFILLLLDVRCEVRSCPILLKTEYFIVLAVLNSATNPIIYTLTNK
EMRRAFIKIMWCCKCPTTDTGTKFKRPIIGGIEFSRSRSDNSSHPQKDEGDSPETIVSSG
NVTSSS

>Pelodiscus sinensis S1PR1
MGSTSSRQKKILNDTVSDYVNSEIIKKHYNYTGKLNEKADSGIKVTSVVFIIICCFIILE
NIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGHKTYSLTPAQWFVREG
SMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISMILGGLPIMGW
NCLDQLHSCSTVLPLYHKHYILFCTTVFTGLLLSIVVLYCRIYSMVRTRSRRLTFRKNFS
KATKSSEKSLALLKTVIIVLSAFIACWSPLFILLLLDVGCKVKACSILFKAEYFLVLAVL
NSATNPIIYTLTNKEMRRAFIKILCCCKCPSADSGAKFKRPIIGGMEFSRSKSDNSSHPQ
KDEGDCPETIMSSGNVTSSS

>Xenopus tropicalis S1PR1
MTPTSATQRRNEYYDHEIIIEHYNYTGKYKGNLSTDIKPTSIIFIIICCFIVLENILVLL
TIWRTKKFHRPMYYFIGNLALSDLLAGTAYTANILLSGPHTYKLTPVEWLIREGSMFVAL
SASVFSLVAIAIERYITMLKMKLHNGSKSSRSFLLISGCWILSLFLGGLPIMGWNCIKQI
SACSTVLPLYHKHYILFCTTIFCALLMAIVILYARIYFLVRTRSRSLTFKRNLARPSRSS
EKSMALLKTVIIVLSVFILCWSPLFIFLLLDFGCKVKTCPVLFKAEYFLSLAVLNSATNP
IIYTLTNREMRRAFLKMACCSHCSIFGSSSKVKRPIITGMEFSRSKSDNSSHPQKDEGEY
PVTLMSSGNVTSSS

>Danio rerio S1PR1 a
MDDLIARHYNFTGKFRKVHKDPGLKADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMY
YFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASVFSLLAIAIE
RHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKA
YILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVI
IVLSCFIACWAPLFILLLLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMR
RAFIKMLNCGVCVQPSGKFSRPIMGAEFSRSKSDNSSHPNKDEPEYSPRETIVSSGNITS
SS

>Takifugu rubripes S1PR1 a
VGPTDQTRKRRQASVEPLYYSDLISKHYNYTGKFRKTQQDSGLKADSVVFIIVCCFIILE
NILVLTTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREG
SMFVALAASVFSLLAIAIERHLTMLKMKLHNNGNTCRVFLLISAVWMVAAVLGGLPVMGW
NCIQIMTQCSTVLPLYHKTYILFCTTVFSIILMAIVVLYARIYALVRTRSRKLVFRKVSN
GRGNSGANVKSSEKSMALLKTVFIVLSCFIACWAPLFILLLLDTACQTLSCPILYKAEWF
LALAVLNSAMNPLIYTLTSNEMRRAFLKTLLCCTSCLRSKVKFSSPIMGAEFSRSKSDNS
SHPNREDGEQSPRGTRTASSGTITLCS

>Tetraodon nigroviridis S1PR1 a
DLISKHYNYTGKFRKTQEDSGLKADSVVFIIVCCFIILENILVLTTIWRTKKFHKPMYYF
IGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASVFSLLAIAIERH
LTMLKMKLHNNGNTWRVFLLISAVWMVAAVLGGLPVMGWNCIQKMSRCSTVLPLYHKTYI
LFCTTVFSIILMAIVVLYARIYTLVRTRSRKLVFRKVSNGRGNAGAAVKSSEKSLALLKT
VFIVLSCFIACWAPLFVLLLLDTACQTLSCPILYKAEWFLALAVLNSAMNPLIYTLTSNE
MRRAFLKTLLCCTACLRPKATFTSPIMGAEFSRSRSDNSSHPTREDGEHSPRGRRTASSG
NVTLSS

>Gasterosteus aculeatus S1PR1 a
SDEISSFIPVCRQKERDDAMAEPNYSDLIAKHYNYTGKYRKTQQDAGLKADSVVFIIVCC
FIILENILVLTTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQW
FIREGSMFVALAASVFSLLAIAIERHLTMLQMKLHNNGNTCRVFLLISAVWMVAAVLGGL
PVMGWNCIRSVTSCSTVLPLYHKTYILFCTTVFSIILMAIVVLYARIYALVRARSRRLVF
RKPTNGRGSAGANMKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDAGCETLSCPILY
KAEWFLSLAVLNSAMNPLIYTLTSNEMRRAFLKTLLCCTACLRPKAKSSGPIMGAEFSRS
SDKYLKRSVLLPLPNNHRSVK

>Gasterosteus aculeatus S1PR1 b
PSAITMSPSTGNLLRMFRSYHNNTVILEHYNFTGKLDAKDYKEGLKPQDIAFLLVCLFIV
AENAVVLLAIWKNKKFHLPMYYLLGNLTLSDLLAGFTYMVNILTSGATTMLLTPVLWFLR
EGGVFIMLAASVISLLAIAIERHVTMVRMKPYQGDKQGRMFALIGASWVLSVFLGVLPVL
GWNCMGRLDQCSTVLPLFSKSYILFCITVFSAILMSIVVLYVRIFRIVKFNTQRLASVPQ
RKGLYRKSQKYMALLKTVTIVLGVFIACWLPLFILLLLDFHCPAKSCSVLFKADYFLVIA
MLNSLLNPIIYTLTSKDMRRAILRLLCRHCLLTKDGQVKKIGIPFLECSTSKTDVASHRL
EGLETTVSSGNLTPST

>Oryzias latipes S1PR1 a
VVSVPIPYLRHIRLQTMAESSYSDLIAKHYNFTGKFRKTQQDSGLKADSVIFIIVCCFII
LENILVLATIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFLR
EGSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGNTCRVFLLISTVWMIAAMLGGLPLM
GWNCIHRMSECSTVLPLYHKTYILFCTTVFSIILMAIVVLYARIYTLVRTRSSKLVFRKV
TNSRGNPSANTKSSEKSLALLKTVIIVLSCFIACWAPLFILLLLDVACETLSCPILYKVD
WFLALAVLNSAMNPLIYTLTSNEMRRAFLKTLLCCTTCIRPKAKFTGPIMGAEFSRSKSD
NSSHPHKEEGEYSPKETTAVSSGNATSSS>Homo sapiens_S1PR1(ENSP_305416)
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS

>Macaca mulatta_S1PR1(ENSMMUP_23379)
MGSTSVPLVKALRSSVSDYVNYDIIVRHYNYTGKLNTSADRENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALPSCSTVLPLYHKHYILFCTVFIACWAPLFILLLLDVGCKVKTCDILFRAEYF
LVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSD
NSSHPQKDDGDNPETIMSSGNVNSSS

>Mus musculus_S1PR1(ENSMUSP_50897)
MVSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSSRSFLLISACWVISLILGGLPIM
GWNCISSLSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKAKTCDILYKAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIVSCCKCPNGDSAGKFKRPIIPGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Canis familiaris_S1PR1(ENSCAFP_29624)
MGSTSVPLVKALRSPVSDYVNYDIIVRHYNYTGKLNTSADKENGIKMSSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLVLGGLPIM
GWNCIGALASCSTVLPLYHKHYILFCTTVFTLLLLAIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRILSCCKCPGGDPAGKFKRPIIAGVEFSRTSLSMVAE
ICLKKSSLSTVWYPAGSLVSQEEQTSKTR

>Felis catus_S1PR1(ENSFCAP_6424)
MGSTSVPLVKTHRSSVSDYVNYDIIVRHYNYTGKLNVSADENGIKLSSVVFILICCFIIL
ENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLRE
GSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISLILGGFPIMG
WNCINMLASCSTVLPLYHKHYILFCTTVFTLLLLAIVILYCRIYSLVRTRSRRLTFRKNI
SKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAV
LNSGTNPIIYTLTNKEMRRAFIRILSCCKCPSEDSAGKFKRPIIAGMEFSRSKSDNSSHP
QKDDGDNPETIMSSGNVNSSS

>Pteropus vampyrus_S1PR1(ENSPVAP_5341)
MGSTSIPLVKALRSPVSDYVNYDIIVRHYNYTGKLNLGTDKDSSIKVTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYAVNLLFSGANTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNESNSSRSFLLISACWIISLILGGLPIM
GWNCISMLPSCSTVLPLYHKHYILFCTTVFTVLLLSIVILYCRIYSLVRTRSRRLTFRKN
TSKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFKVEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIKIMSCCKCPRGDTTGKFKRPIIAGVEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS

>Gallus gallus_S1PR1(ENSGALP_41717)
MSSGTTAPVRVVSSLTNTDVNYVIKEHYNYTGKLNENADSGIKVTSVVFIIICCFIILEN
IFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGHKTYSLTPSQWFVREGS
MFVALSASVFSLLAIAIERYITMLKMKLHNGSNSFRSFLLISACWVISVILGGLPIMGWN
CISLLSNCSTVLPLYHKHYILFCTTVFTGLLLSIVVLYCRIYSMVRTRSRRLTFRKNITK
ATRSSEKSLALLKTVIIVLSAFIACWAPLFILLLLDVGCRVKTCPILYKAEYFLVLAVLN
SATNPIIYTLTNKEMRRAFIKILCCCKCPPTDSGTKFKRPIIGGMEFSRSKSDNSSHPQK
EEGDRPETIMSSGNVTSSS

>Xenopus tropicalis_S1PR1(ENSXETP_29045)
MTPTSATQRRNEYYDHEIIIEHYNYTGKYKGNLSTDIKPTSIIFIIICCFIVLENILVLL
TIWRTKKFHRPMYYFIGNLALSDLLAGTAYTANILLSGPHTYKLTPVEWLIREGSMFVAL
SASVFSLVAIAIERYITMLKMKLHNGSKSSRSFLLISGCWILSLFLGGLPIMGWNCIKQI
SACSTVLPLYHKHYILFCTTIFCALLMAIVILYARIYFLVRTRSRSLTFKRNLARPSRSS
EKSMALLKTVIIVLSVFILCWSPLFIFLLLDFGCKVKTCPVLFKAEYFLSLAVLNSATNP
IIYTLTNREMRRAFLKMACCSHCSIFGSSSKVKRPIITGMEFSRSKSDNSSHPQKDEGEY
PVTLMSSGNVTSSS

>Danio rerio_S1PR1(ENSDARP_62632)
MDDLIARHYNFTGKFRKVHKDPGLKADSVVFIIVCCFIILENVLVLLTIWRTKKFHKPMY
YFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASVFSLLAIAIE
RHLTMLKMKLHNNGKTCRVFMLISTVWFIAAILGGLPVMGWNCIDSINNCSTVLPLYHKA
YILFCTTVFSVILMAIVILYARIYALVRTRSRKLVFRKVANGRGSNKSSEKSMALLKTVI
IVLSCFIACWAPLFILLLLDVACQTLTCSILYKAEWFLALAVLNSAMNPLIYTLTSNEMR
RAFIKMLNCGVCVQPSGKFSRPIMGAEFSRSKSDNSSHPNKDEPEYSPRETIVSSGNITS
SS

>Takifugu rubripes_S1PR1(ENSTRUP_24703)
VGPTDQTRKRRQASVEPLYYSDLISKHYNYTGKFRKTQQDSGLKADSVVFIIVCCFIILE
NILVLTTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREG
SMFVALAASVFSLLAIAIERHLTMLKMKLHNNGNTCRVFLLISAVWMVAAVLGGLPVMGW
NCIQIMTQCSTVLPLYHKTYILFCTTVFSIILMAIVVLYARIYALVRTRSRKLVFRKVSN
GRGNSGANVKSSEKSMALLKTVFIVLSCFIACWAPLFILLLLDTACQTLSCPILYKAEWF
LALAVLNSAMNPLIYTLTSNEMRRAFLKTLLCCTSCLRSKVKFSSPIMGAEFSRSKSDNS
SHPNREDGEQSPRGTRTASSGTITLCS

>Tetraodon nigroviridis_S1PR1(ENSTNIP_5798)
DLISKHYNYTGKFRKTQEDSGLKADSVVFIIVCCFIILENILVLTTIWRTKKFHKPMYYF
IGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFFREGSMFVALAASVFSLLAIAIERH
LTMLKMKLHNNGNTWRVFLLISAVWMVAAVLGGLPVMGWNCIQKMSRCSTVLPLYHKTYI
LFCTTVFSIILMAIVVLYARIYTLVRTRSRKLVFRKVSNGRGNAGAAVKSSEKSLALLKT
VFIVLSCFIACWAPLFVLLLLDTACQTLSCPILYKAEWFLALAVLNSAMNPLIYTLTSNE
MRRAFLKTLLCCTACLRPKATFTSPIMGAEFSRSRSDNSSHPTREDGEHSPRGRRTASSG
NVTLSS

>Gasterosteus aculeatus_S1PR1(ENSGACP_17890)
SDEISSFIPVCRQKERDDAMAEPNYSDLIAKHYNYTGKYRKTQQDAGLKADSVVFIIVCC
FIILENILVLTTIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQW
FIREGSMFVALAASVFSLLAIAIERHLTMLQMKLHNNGNTCRVFLLISAVWMVAAVLGGL
PVMGWNCIRSVTSCSTVLPLYHKTYILFCTTVFSIILMAIVVLYARIYALVRARSRRLVF
RKPTNGRGSAGANMKSSEKSMALLKTVIIVLSCFIACWAPLFILLLLDAGCETLSCPILY
KAEWFLSLAVLNSAMNPLIYTLTSNEMRRAFLKTLLCCTACLRPKAKSSGPIMGAEFSRS
SDKYLKRSVLLPLPNNHRSVK

>Oryzias latipes_S1PR1(ENSORLP_17674)
VVSVPIPYLRHIRLQTMAESSYSDLIAKHYNFTGKFRKTQQDSGLKADSVIFIIVCCFII
LENILVLATIWRTKKFHKPMYYFIGNLALSDLLAGVVYTANILLSGANTYKLTPTQWFLR
EGSMFVALAASVFSLLAIAIERHLTMLKMKLHNNGNTCRVFLLISTVWMIAAMLGGLPLM
GWNCIHRMSECSTVLPLYHKTYILFCTTVFSIILMAIVVLYARIYTLVRTRSSKLVFRKV
TNSRGNPSANTKSSEKSLALLKTVIIVLSCFIACWAPLFILLLLDVACETLSCPILYKVD
WFLALAVLNSAMNPLIYTLTSNEMRRAFLKTLLCCTTCIRPKAKFTGPIMGAEFSRSKSD
NSSHPHKEEGEYSPKETTAVSSGNATSSS

>Homo sapiens_S1PR2(ENSP_466933)
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV

>Pan troglodytes_S1PR2(ENSPTRP_60209)
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADVAAPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAFSTLNSLLNPVIYTWRSRDLRREVL
RPLQCCRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV

>Macaca mulatta_S1PR2(ENSMMUP_8664)
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADVAGPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVL
RPLQCWRPGVGVQGRRRDGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV

>Mus musculus_S1PR2(ENSMUSP_53394)
MGGLYSEYLNPEKVLEHYNYTKETLDMQETTSRKVASAFIIILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGHVTLSLTPVQWFAREGSAFITLSASV
FSLLAIAIERQVALAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLNQLEACS
TVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLG
VFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVL
RPLQCWRRGKGVTGRRGGNPGHRLLPLRSSSSLERGMHMPTSPTFLEGNTVV

>Canis familiaris_S1PR2(ENSCAFP_26380)
MGNLYSEYLSPNKVREHYNYTKETLDTQETASRQAALVIIIILCFAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDMLTGVAFVANTLLSGPVTLGLTPIQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISVALGGLPILGWNCLGHLEACS
TVLPLYTKHYVLCVVTIFSVILLAIVALYVRIYCVVRSSQADVAGPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVRSCPILYKAHYFFAFATLNSLLNPVIYTWRSRDLRREAQ
RFGKR

>Felis catus_S1PR2(ENSFCAP_12060)
MGSLYSEYLSPSKVLEHYNYTKETLDTQETTSRWVALVIIVLICFTIVVENLMVLIAVAR
NSKFHSAMYLFLGNLAASDLLTGVAFVANTLLSGPVTLGLTPLEWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIVASWLISLVLGGLPILGWNCLGHLEACS
TVLPLYTKHYVLCVVTIFSVILLAIVALYIRIYCVVRSSHVDVTGPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVRSCPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVL
RPLQCCRRAAGVQGRRGGTPGHRLLPLRSSSSLERGTHMPTSPTFLEGNTMV

>Pteropus vampyrus_S1PR2(ENSPVAP_3478)
MGSLYSEYLSPTKVQEHYNYTKETLDTQETPSRKVASALIIILCCAIVVENLLVLIAVAR
NSKFHSAMYLFLGNLAASDLLAGVAFIANTLLSGSVTLRLTPVQWFAREGSAFITLSASV
FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIAASWLISLALGGLPILGWNCLGHLEACS
TVLPLYAKHYVLCVVTIFSAILLAIVVLYIRIYCVVRSSHADVAGPQTLALLKTVTIVLG
VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAFATLNSLLNPVIYTWCSRDLRREVL
RPLQCWRQAAGVQGRRSGTPGHHLLPLRSSSSLERGTHMPTSPTILEGNTVV

>Danio rerio_S1PR2(ENSDARP_53105)
MTTCRLFAGFCQAVTMSKYSQYFNKTLIQVHYLTAKEMTAEELRDRIESKQSLSSLNILF
VVICSIIILENLLVLIAVFRNKKFHSAMFFFIGNLAFSDLLAGSAYIANIFLSGPRTFHL
TPVQWFIREGTAFIALSASVFSLLAIAIERYIAITKVKVYGSNKTCRMFLLIGACWVMSI
LLGGLPIIGWNCINNLDDCSAVLPLNTRYYIRFVVTIFSIILLSIVILYVRIYLIVRTSH
QEATNSPAYALLKTVTIVLGVFIICWLPAFTILLLDTSCKMKQCPILNNAGIFFSFATLN
SALNPLIYTLRSKDMRKEFLRVLCCWGLLNCGRPPHRCMVPLKSSSSMEHCTNKHEHQSI
PIMQDCTTCV

>Tetraodon nigroviridis_S1PR2(ENSTNIP_2390)
MKSKYSQYYNKSLIQCYYIFAKNLTPQDLSKRNDNKNQLPTLNIVIVVLCTIIILENLLV
LIAVCRNKKFHSAMFFFIGNLAFSDLLTGSAYIANIFLSGSRTFELMPIQWFIREGTAFI
ALAASVFSLLAIAVERYLAITKVKVYGATKTCRMFLLIGASWVTSILLGGLPILGWNCIN
NLPECSAVLPLYSKKYILFVVTIFSIILLSIVILYVKIYLIVRSSRQEATNSATYSLLKT
VTIVLGVFILFWLPAFTILLLDSFCNIQFCSILSEAQMFFGFATLNSALNPVIYTLRSKD
MRKEFLRVLCCWGVLQSGRPSDRCLVPLKSSSSLEHCTHKHEHQTMPIMQDCTTCV

>Gasterosteus aculeatus_S1PR2(ENSGACP_18176)
LGSVRVPSFTYSMKSKYSQYYNQSLIHSYYTFAKNMSTQELAKRIENKKKLSSLDMVIVV
LCTIIILENLLVLIAVCRNKKFHSAMFFFIGNLAFSDLLAGSAYIANIFLSGSRTFDLMP
VQWFIREGTAFIALAASVFSLLAIATERYIAITKVKVYGSTKTCRMFLLIGACWVTSILL
GGLPIMGWNCINDLPECSAVLPLYSKKYILFVVTIFSLILLSIVILYVRIYLIVRSSHQE
ATNLPAYALLKTVTIVLGVFIMCWLPAFTILLLDTSCRIQFCPILSKAEFFFSFATLNSA
LNPVIYTLRSKDMRKEFLRVLCC

>Oryzias latipes_S1PR2(ENSORLP_6996)
VGRTSYPPAVFCPFHKSKYSQYYNTNLIRLHYAHAKNMSKAEIHERESEKDHPDLLSIII
LVICTIIIFENLLVLMAVWRNKKFHSAMFFFIGNLAFSDLLAGCAYIVNIILSGPRTYSL
CPVQWFIREGTAFIALAASVFSLLAIAIERYVAITKVKVYGSNKSCRMFLLIGACWVTSI
LLGGLPILGWNCIFDLGDCSTVLPLYSKKYIVFVVTVFSLILLSILILYVRIYLIVRSSN
QVTTNMQAYSLLKTVTIVLGVFIVCWLPAFTILLLDSSCSIQVCTILDKAKIFFGFATLN
SALNPVIYTLRSKDMRREFLRVLCC

>Homo sapiens_S1PR3(ENSP_350878)
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN

>Pan troglodytes_S1PR3(ENSPTRP_55915)
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMV
LIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFV
ALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLH
NLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPVLFKAQWFIVLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAP
SSCIMDKNAALQNGIFCN

>Macaca mulatta_S1PR3(ENSMMUP_26785)
XREHYQYVGKLAGRLMEASEAGTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFF
IGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERH
LTMIKMRPYDANKKHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYI
AFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWS
PLFILFLIDVACRVQACPVLFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCL
VRGRGARASPIQPALDPSRSKSSSSNNSTHSPKVKEDLPHTAPSSCIMDKNAALQNGIFC
K

>Mus musculus_S1PR3(ENSMUSP_85293)
MATTHAQGHQPVLGNDTLREHYDYVGKLAGRLRDPPEGGTLITTILFLVTCSFIVLENLM
VLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGRKTFSLSPTVWFLREGSMF
VALGASTCSLLAIAIERHLTMIKMRPYDANKKHRVFLLIGMCWLIAFSLGALPILGWNCL
ENFPDCSTILPLYSKKYIAFLISIFTAILVTIVILYARIYCLVKSSSRRVANHNSERSMA
LLRTVVIVVSVFIACWSPLFILFLIDVACRAKECSILFKSQWFIMLAVLNSAMNPVIYTL
ASKEMRRAFFRLVCGCLVKGKGTQASPMQPALDPSRSKSSSSNNSSHSPKVKEDLPRVAT
SSCIIDKNRSFQNGVLCK

>Canis familiaris_S1PR3(ENSCAFP_3210)
MCLRRPLLGSGAEPLRARAMATVVPPRARPSPGNGNETETLHEHYNYVGKLEGRLREAPE
GSMPTTVLFLIICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNIL
MSGKRTLSLSPTLWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKKHRVFLL
IGMCWLIAFSLGALPILGWNCLHNLPDCSTILPLYSKRYIAFCISIFTAILVTIVILYAR
IYFLVKSSSRRVASPHNSERSMALLRTVVIVVSVFIACWSPLFILFLVDVACRVKQCAIL
FKAQWFIVLAVMNSAMNPVIYTLASKEMRRAFFRLVCTCLVRRWGARSSPTQPALDPSRS
KSSGSNNSSPSPKSKEDPPQIAASPCIMDGNKTLQNGILCK

>Felis catus_S1PR3(ENSFCAP_3879)
QHYNYVGKLEGRLKEAPEGSTLTTVLFLVICSFIVLENLMVLIAIWRNNKFHNRMYFFIG
NLALCDLLAGIAYKVNILMSGKRTLSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLT
MIKMRPYDANKKHRVFLLIGMCWLIALSLGALPILGWNCVHDLPDCSTILPLYSKKYIAF
CISIFTAILVTIVILYARIYFLVKSSSRRVASPHNSERSMALLRTVVIVVSVFIACWSPL
FILFLVDVACRVKECAVLFKAQWFIMLAVLNSAMNPVIYTLASKEMRRAFFRLVCTCLVR
GRGARSSPTQPALDPSRSKSSGSNNSSPSPKSKEDPPQRVASPCITDGNK

>Myotis lucifugus_S1PR3(ENSMLUP_6014)
LYEHYNYVGKLAGRLTDAPEGSALTTVLFLVICSFIVLENLMVLIAIWKNKKLHNRMYFF
ISNLALCDLLAGIAYKVNILMSGKRTLSLSPTVWFLREGSMFVALGASTCSLLAIAIERH
LTMIKMRPYNANKKHRVFLLIGMCWLIALSLGALPILGWNCLQNLPDCSTILPLYSKKYI
AFCISIFTAILVAIVILYARIYCLVKSSSRRVANPQHSERSMALLRTVVIVVSVFIACWS
PLFILFLVDVACKVKECAVLFKDKWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCL
VRAQGTRSLPIQLTLDPSKSKSSGSNSSPSPKSKEDITQTAPSPCITDRNK

>Xenopus tropicalis_S1PR3(ENSXETP_62916)
NMASGSLPSKKLEPRRCDEVINRHYNYTGKLKERELDHMDMTEIVFLIICSLIVLENLMV
LIAIWKNNRFHNRMYFFIGNLALCDMLAGIAYIVNICMSGSKTMDISLTAWFVREGSMFI
ALGASTFSLLAIAIERHLTMIKMRPYDANKKYRVFLLIGTCWLISFSLGALPILGWNCIE
DLPNCSTILPLYSKRYVGFCISIFIAILIAIVILYARIYILVKSSSRRVTNHSNSERSMA
LLRTVVIVVGVFIACWSPLFILLLIDVACEVKTCSILYKAQWFIALAVLNSALNPVIYTL
ASKEMRRAFFRLVCSCLVKTNNSRSLPIQPTPDQSRSKCSSSSNSPKHKSIIQTNGHRNT
SN

>Danio rerio_S1PR3(ENSDARP_136495)
MINQHIYNHYNFTGKLDNRNETKGAPMDPKIMAFYVVCSLIVLENLIVLVAIWRNHKFHN
RMYFFIANLALCDLLAGVAYIANILMSGQRTLHLSPAEWFIREGSMFVALGASIFSLLAI
AIERHLTMIKMRPYDANKNYRVFLLIGTCWLIAITLGSLPILGWNCLEDLPQCSTILPLY
SKNYVAFCITIFISLLLAISILYARIYVLVKSSSRKVTKHSNCERSMALLRTVSIVVGVF
IACWTPIFVLLLIDVACGPKRCPVLLKADWFVALAVLNSAMNPVIYTLASREMRRAFYKL
ICGCLVKDGVVGCKNTDPSRSKSSSNCPRVAEQENQDVCNS

>Tetraodon nigroviridis_S1PR3(ENSTNIP_21941)
MMINPQIYLHYNYTGKLDHRPTMGASPGTVDAKTVAFLVVCGFIVLENLTVLLAIWRNHR
FHNRMYYFIGNLALCDLLAAVAYLVNLLLSGEKTLQLSPVRWFIREGSMFVALSASIFSL
LAIAIERHLTMIKMRPYDASKNYRVFLLIGTCWLVAVSLGALPLLGWNCLGDLPDCSTIL
PLYSKKYVAFCIIVFIVLLLAISVLYARIYILVKSSSQKVSKHRNSEHAMSLLRTVIIVV
GVFIACWTPIFVLLLLDVACERRCSILYRADWFIGVAVLNSAMNPVIYTLASREMRRAFL
GLACAFCYRVKGSGTDSGNKQSLEPSRSRSKSWSSQNHPNQSQQSSRPAGLDRERETGHG
EITVVAGGTTQVVPRREGK

>Gasterosteus aculeatus_S1PR3(ENSGACP_21811)
KMINPQIYLHYNYTGRLDHRPTIGASPGAVDAKTVVFLVICSCIVLENLAVLVAIWRNHR
FHNRMYFFIGNLALCDTLAGVAYLVNLLLSGEKTLQLSPALWFVREGSMFVALCASIFSL
LAIAIERHLTMIKMRPYDASKNYRVFLLIGACWLIAISLGALPILGWNCLDNLPDCSTVL
PLYTKKYVAFCITVFIVLLVAMSVLYARIYILVKSSSQKVSKNRNSEHAMSLLRTVTIVV
GVFIACWTPILVLLLVDVACARSCPVLYEADWFIGLAVLNSAMNPVIYTLASREMRRAFL
GLACGVCYGGKASAKVGGNRRPLEPSRSRKSWSSQNNPNQGRGSSVQAEAEEGKETDTSH
GEVSLVAGGAGHATAPVGQQDIGGR

>Oryzias latipes_S1PR3(ENSORLP_7246)
HYNYTGKLGHRNCSGSSPGTVDAKTTVFLIICCLIVLENLTVLVAIWRNHKFHNRMYFFI
GNLALCDLLAGVAYAVNLFLSGEKTLQLSTTVWFIREGSMFVALSASIFSLLAIAIERHL
TMIKMRPYNSNKNYRVFLLIGACWVVGITLGALPILGWNCLDNLSDCSKVLPLYSKKYVA
FCITVFMGLLLAMSILYARIYILVKSSSRKVSKHSSSEHAMSLLRTVIIVVGVFIVCWTP
VFILLLVDVSSEERFFIIYNAEWFIIVAMLNSAMNPVIYTLASREMRRAFLGLICGACYR
HRGSATGSGNRQYLEPSRSRSKSWSSQNNPNQQHQPSSMSCDLDAGAWWHLQLGSMCN

>Homo sapiens_S1PR4(ENSP_246115)
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI

>Pan troglodytes_S1PR4(ENSPTRP_17428)
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI

>Macaca mulatta_S1PR4(ENSMMUP_22418)
MNATGTPVAPESCQQLAAGGHSRLIVMHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTGRVYSFIGLCWLLATLLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFASVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLGFLCCGCLRLGMRGPGDCLARAVEAHSGTSTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI

>Canis familiaris_S1PR4(ENSCAFP_28441)
MNGTGPPAAAPESCQQLAASGHSRLIVLHYNHSGRLAGRAGPDEGSLGVLRGVFVAASCL
VVLENLLVLVAIATRMRSRRWVYYCLVNITLSDLLTGVAYLANVLLSGARTFHLAPAQWF
LREGLLFMALAASTFSLLFTAGERFATMVRPVAESGASKRGRVYGFIGLCWLLAALLGLL
PLLGWNCVCAFPRCSSLLPLYSKAYILFCVGVFACILAAIMALYGAIFRVVRANGQKAPR
APARRKARRLLKTVLMILLAFVVCWGPLFGLLLADVFSSTDWAQEYLRGMDWILALAVLN
SAVNPLIYSFRSREVCQAVLGFLCCGCLRLGLRGPRDCLAQVTEAQSSTTDSSLRPRDSF
RGSRSLSFRMREPLTSISSVRSV

>Felis catus_S1PR4(ENSFCAP_6609)
MNGSGSPAEAPESCQQLAAGGHSRLIALHYNHSGRLAGRGGPEEGGLGVLRGLFVAVSCL
VVLENLLVLLAIVSRMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFLLAPTEWF
LREGLLFMALAASTFSLLFTAAERFATMVRPVAKSGAGKTGRVYGFIGLCWLLAVLLGLL
PLLGWNCVCSFRRCSSLLPLYAKEYILFCVAVFACILAAIMVLYGAIFRVVQANGQKASR
VLARRKARRLLETVLMILAAFLVCWGPLFGLLLADVFSSNDWAQEYLRGMDWILALAVLN
SAVNPLIYSFRSREVCQAVLGFLCCGCLRLGLRGPGDCLAKAAEAHSEASTTDSSLRPRD
SFRGSRSLSFRMREPLSSISSVRSI

>Pteropus vampyrus_S1PR4(ENSPVAP_11082)
MNTTGSPAEAPEACQQLAASGHSQLIVLHYNHSGRLLGRAEPEDGGLGVLRGLFVAVSSL
VVLENLLVLAAIVTRMRSRRWVYYCLVNITLSDLLTGLAYLVNVLMSGPQTFHLAPASWF
LREGVLFMSLAASTFSLLFTAGERFATMVRPVAESGNTKRGRVLGFIGLCWLLAALLGLL
PLLGWNCVCAFQSCSSLLPLYSKAYILFCVVIFACILATITVLYGAIFRVVRANGQKASR
HPVRRKARRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDWILALAVLN
SAINPLIYSFRSREVCRAVLGFLCCGCLRLGLRGPGDCLARAAEAHSGASTTDSSLRPRD
SFRGSRSLSFRMREPLTSISSVRSV

>Xenopus tropicalis_S1PR4(ENSXETP_31380)
PSCGTMNLTQEHLFCLELMANRNINIILWHYNLTGRLSGRSSKGIGIFHLLGILISVLII
LENLSVLLALLRDPRMRRWVHCCLGNIALSDLLAGISYLLNLFLSGPTTFRLSPALWFLR
EGLLFTTLAASTFSLLVTAVERYCTMVILVTENNSVKSMRVQGVIVLCWVLAGVVGFLPL
LGWNCLCKIESCSSLLPLYSRTYLFFSIILLGVTLLGIIAAYCTIYYLVCTSGRRVAETN
SSRRSFHLLKTVLIILSAFVICWSPLFFFLIVDFTCSPPSCKSPLGLEWVLAVAVLNSAI
NPLIYSFRSSEMRRAVLELFCCVCIRAGVKPPACCQLGTEITSGSSNEGSYKNRSSVRLS
RALSVRSPLTSISSAPSQ

>Danio rerio_S1PR4(ENSDARP_112534)
MEVLRSFSSASSCPDVYNWTSNSLILEHYNYTGRLHHRKPSKKSVSAVTVLFLCFSVFII
LENLMVLLAVLFRVRLRHRWIFICIANIALSDLLTGTSYVVNICMSGEQTFRLTPILWLF
REGLLFVALAASIFSLLLIAVERYATMMKPVHQKTATKTYRVYIMMLLCWITAFIIGFLP
LMGWNCVCDLRSCSTLLPLYSKSYILFALVIFFIILLTIGVLYFAIYCHVRSSTETISAR
SRKRSLRLLKAVISIVGVFMVCWGPLFILLLVDFFCYSRSCSPLFNPEWVIALAVLNSAM
NPLIYSFGSLELRKAIATLLCCSCLKAGLCDPKTFMSKETSSTSGSRHSSLRNSFSKVRN
LSTSPPPEPKNGKKTRLSSTTSCLSASSG

>Takifugu rubripes_S1PR4(ENSTRUP_30129)
HYNHTGRLQNRIMSNGQTQISTTSALFLFLSILIILENLLVLVAISSRIRHSRRWVYVCI
ANITLSDLLTGTAYVVNICLSGSKTFHLTLPLWLFREGLLFVALAASIFGLLLIAVERCM
TMMKPLPQKSAGKSYCRIFSFVALCWFWALVIGFLPLLGWNCICSLEGCSTLLPLYSKSY
IFFSVIIFFIILLTIGVLYGAIYCHVHRSAQQGLQRSRRHSLSLLKTVITIVGVFIVCWG
PLFLLLLVDFFCVSRQCGLLFTADVCISLAVFNSALNPIIYALGSSEMRKAMTELLCCCC
LRSDFCHPDTFTSKETSSTSESRRDSLRNSFN

>Tetraodon nigroviridis_S1PR4(ENSTNIP_128)
LVSPTLCPQVYTLPGNLSANSSLNYVILRHYNHTGRLQNRNTSNVYPHLSGSRLFFLCLS
VFITLENLLVLGYIHHSRRWVYICIANITLSDLLTGTAYVVNICLSGSTTFHLSLPLWLF
REGMLFVALAASIFGLLLIAVERYLTMIRPLPQKSARKSYCRIFSLVALSWFMALVIGFL
PLLGWNCICSMEECSTLLPLYSKSYIFFSLLIFFFILLTIGVLYAAIYCHVHRSTQLGQQ
HSRKRSVALLKTVVTIVGVFILCWGPLFTLLLVDFFCDSRQCPILFSADICICLAVLNSG
LNPIIYALGSSEMRKAMAKLLCCSC

>Gasterosteus aculeatus_S1PR4(ENSGACP_13913)
VILRHYNHTGRLQNRTTSDPHNYISASMAVFLFFSIFIILENLLVLVAVISRIAHSRRWV
YVCIANITLSDLLTGAAYLVNICMSGSQTFRLTPALWLFREGVLFVALAASIFSLLLIAV
ERYTTMIKPLPQKAAKKTYCRIYGLVALCWILAMVIGFLPLLGWNCVCSLDGCSTLLPLY
SKSYIFFSLIIFFLILLAIGVLYGAIYCHVHKSAQLGSLRSRKRSLDLLRTVITIVGVFM
LCWGPLFLLLMVDFFCDSRQCALLFSADFCISLAVLNSGLNPVIYALGSSDMRKAIAKLL
CCCCLKAGLCRPDTFTSKETSSTSGSRRDSLRNSFNKVRNLSVASPPATPSKPRKA

>Oryzias latipes_S1PR4(ENSORLP_21851)
LAMNSLSFLTSPSSCPHLYNYPNTTSPNASAGISYVILLHYNHTGRLQNRTFSSAQSHIS
VSMAVFLSFSFFIVLENFLVLLAVISRIRHSRRWVYVCIANITLSDLLTGTAYLVNICMS
GRQTFRLTPALWLFREGMLFVALAASIFSLLLIAVERYTTMMTPLPQKSTRNTYYRIYGL
VALCWALALAIGFLPLLGWNCVCNLDECSTLLPLYSKTYVLFSLVIFFLILLAIGVLYGA
IYCHVHKSAQLGPQRSRKRSLALLKTVITIVGVFMLCWGPLFLLLIVDFFCVSRQCALLF
SADFCISLAVLNSGLNPIIYALGSSDMRKAIAELLCCCCLRAGLCRPDTFTSKETSSTSE
SRRDSLRNSFSKVRNLSVASPPSTPSKPRKT

>Homo sapiens_S1PR5(ENSP_416915)
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

>Gorilla gorilla_S1PR5(ENSGGOP_12447)
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

>Callithrix jacchus_S1PR5(ENSCJAP_12320)
MESWLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLRLSPALWFAREGGVFVALA
ASVLSLLAIALERSLTMARRGPAPAASRGRTLAMAATAWGMSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILGAICALYVRIYCQVRANARRLQARPGTAGATLTRA
RRTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARACPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHPCGRGPGGSPQSGSPAEASGGLRRCLPPGLDGSF
SRSERSSPQRDGLDTSGSTGSPGAPTAARTLVPEPAAD

>Mus musculus_S1PR5(ENSMUSP_113843)
MEPGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAAVCLAVCAFIVLENLAVLLV
LVRHPRFHAPMFLLLGSLTLSDLLAGAAYATNILLSGPLTLRLSPALWFAREGGVFVALA
ASVLSLLAIALERHLTMARRGPAPAASRARTLAMAVAAWGASLLLGLLPALGWNCLGRLE
TCSTVLPLYAKAYVLFCVLAFLGILAAICALYARIYCQVRANARRLRAGPGSRRATSSSR
SRHTPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARACPVLLQADPFLGLAMANS
LLNPIIYTFTNRDLRHALLRLLCCGRGPCNQDSSNSLQRSPSAAGPSGGGLRRCLPPTLD
RSSSPSEHLSPQQDGVDTSCSTGSPGVATANRSLVPTATD

>Canis familiaris_S1PR5(ENSCAFP_26216)
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVSLAVCALIVLENLAVLFV
LARHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLRLSPALWFAREGGVFVALA
ASVLSLLAIALERRLTMARRGPAPASRRGRTLALAGAAWGVSLFLGLLPALGWNCLGRLD
SCSTVLPLYAKAYVLFCVLAFLGILATICALYGRIYCQVRANARRLRERPGASGGASTRA
RRPPRSLALLRTLSLVLLAFLMCWGPLFLLLLFDVACPARACPVLLQADPFLGLAMANSL
LNPIIYTFTNRDLRHALVRLLCCGRRPCTREQDASQGSGSPAGASEGLNRWLPPGLDGSC
RHLGRLSPQPDGLDTSGSTGGPGAPTASWTLVHAPAAD

>Pteropus vampyrus_S1PR5(ENSPVAP_3494)
MEPGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCALIVLENLAVLFV
LGRHPRFHAPMFLLLGSLALSDLLAGAAYAANILLSGPLTLRLSPALWFAREGGVFVALA
ASVLSLLAVALERSLTMAHRGPAPASRRGRILALAAAVWGISLFLGLLPALGWNCLGHLD
ACSTVLPLYAKAYVLFCVLIFLSILTAICALYARIYCRVRANSRRLRARPGVVGGPCSGA
RRTPRSLPLLRTLSLVLLAFMACWVPLFLLLLLDVACPARACPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLCLICCGRRPCGGGPGASQRSGSAAGASDGLHPWLPPGLDGST
SRSEHSSPQRDQLETSGSTVAPTAAGTLVPATAAD

>Danio rerio_S1PR5(ENSDARP_115650)
MEASYAASAAIEPTPPPMTSSPGYMFSMFREYQSNAVIMAHYNFTGKLKENKYRDGLKPE
AIAFLIICLLIVVENAIVLVAIWKNKKFHMPMYYLLGSLTLSDLLAGFTYMVNIVTSGAN
TLKMTPVLWFLREGGVFITLAASVISLLAIAIERHVTMVRMKPYQGAKRGRMFGLIGASW
LLSILLGILPIMGWNCIGNLDECSTVLPLYAKSFILFCITVFTLVLMSIVVLYVRIFRIV
KSNTQRLGFGTQRKGLARKSQKYLALLKTVTIVLGVFIACWLPLFVLLLLDFSCPAQSCE
VLFKADYFLGIAMINSLLNPIIYTLTSKDMRRAILRLVCSYCLLTKDGQVKKFGMPFLDC
STSRAEVPSHRLEGLETTVSSGNFTPSTIKAIYPRILKS

>Takifugu rubripes_S1PR5(ENSTRUP_10450)
VASSGSIGVGEIYRHFFQEYQAISVLVEHYNYTGKLKDRYREGLKPEGIAFLVVCLLIVL
ENAVVLVAIWRNKKFHLPMYYLLGNLTLSDLLAGITYMANIIMSGPNTLKLTPLLWFLRE
GGVFITLAASVISLLAIAIERHVTMVTMRPYHGAKRGRMVALIGASWALAGFLGVLPILG
WNCIHSLDQCSTVLPLYAKSYILFCVTVFSAVLLAIVVLYVRVFRIVRINTQRQRLGLSG
SLRKGLARKSQKYIALLKTVTIVLGVFIACWLPLFLLLLLDFFCPTRIWLLYKADYFLGV
AMVNSLLNPIIYTLTSKDMRRAILRLLCRPCLMTKDGQVKKIGMPFLECSFSKTELPSQK
LEGGVETTVSSGNVITTP

>Tetraodon nigroviridis_S1PR5(ENSTNIP_7191)
SVLVKHYNYTGKLQKDRYREGLKPEGIAFLVVCLLIVLENAVVLVAIWRNKKFHLPMYYL
LGNLTLSDLLAGITYMANIIMSGPNTLKLTPLMWFLREGGVFITLAASVISLLAIAIERH
VTMVTMRPYHGAKRGRMLALIGASWALAGFLGVLPILGWNCIHSLDQCSTVLPLYAKSYI
LFCVTVFSAVLLAIVVLYVRVFRIVRINTKRQRLGLSGNLRKGLARKSQKYIALLKTVTI
VLGVFIACWLPLFLLLLLDFFCPTRTYWLLYKADYFLGVAMVNSLLNPIIYTLTSKDMRR
AILRLLCRPCLMTKDGQVKKIGMPFLECSFSKTDVASQKLEGGLDTTVSSGNVITTP

>Gasterosteus aculeatus_S1PR5(ENSGACP_25745)
MTSSSFMLSQSILRCQKNEYQDNSVLVQHYNYTGKLQKDRYREGLKPENIAFLVVCLLIV
LENAVVLIAIWRNKKFHLPMYYLLGNLTLSDLLAGITYMANIIMSGHNTLRLTPLLWFLR
EGGVFITLAASIISLLAIAIERHVTMVTMRPYHGAKRGRMLALIAASWALAGFLGVLPIL
GWNCIRRLDQCSTVLPLYAKSYILGCVSVFSAVLLAIVVLYVRVFRIVRTNTQRQRLGLS
GSMRKGLARKSQKYIALLKTVTIVLGVFIACWLPLFVLLLLDFFSPTRSCPLLYKADYFL
GVAMVNSLLNPIIYTLTSKDMRRAILRLLCRPCLMTRDGQVKKIGMPFLECSFSKSEVTA
QKLEGGMETTISSGNVITNS

>Oryzias latipes_S1PR5a(ENSORLP_19248)
SSAPSAVPQSAGMVSRFSQYLRNAVISEHYNYTGKLKEDKYKEGLKPEAIAFLLVCLLIV
VENAIVLVALWKNKKFHVPMYYLLGNLTLSDMLAGLTYMANIMTSGHITLKMTPILYFLR
EGGVFITLAASVISLLAIAIERHVTMVRMKPYQGDKQGRMCALIVGSWMLSVFLGILPVL
GWNCIGRLEQCSTVLPLYAKSYILFCITVFSAILMSIIVLYVRIFRIVKSNTQRLASVPQ
RKGFYRRSQKYMALLKTVTIVLGVFIACWLPLFILFLLDFSCAVKLCKILFKAEYFLGIA
LINSLLNPIIYTLTSKDMRKAIIRLLCQPCLITENGQVRKIGVHFLDCSTTKMEGTSHRL
EGLETTVSSGNFTHSV

>Oryzias latipes_S1PR5b(ENSORLP_4722)
WFLLYIKFICPNKSVIVDHYNYTGKLKDDRCHVGLKPESIALLVLCGIIILENAVVLIAI
WRNKKFHLPMYYLLGNLTLSDLLAGIAYIANILMSGPHTLKLTPLLWFLREGGVFITLAA
SVICLLAIAIERHFTMMAMRPYHGAKRGRMVALIIASWALAGFLGVLPILGWNCIGKLDQ
CSTVFPLYDKSYILFCVSVFSAVLLAIVVLYARVFHIVRTNTQRQRQGLTGPTRRSLSRK
SKKYIALLKTVTIVLGVFIACWMPLFVLFLLDFFCSSGKCELLYKADYFLGLAMINSLLN
PIIYTLTSRDMRVAILRLLCLPCLIATGGQINRFGTFLEYSFSRSEVGSQRLDVGQESII
STGNIINTSSPIKSIYPKLFKS

>Drosophila melanogaster_(FBpp0084947)
MSAFRYFSITDFSFEGPLLPLHAATTSKDAKDSDSPSSELNIPYTVFEVLVAIVSIIGNV
LVIIVFRRERKLRRRTNYYIVSLAMADLLVGALGIPFAILASMGLPRNLHACLFTVSLLV
VLCTISIFCLVAVSVDRYWAILYPMAYSRNVRTRTAIFIISMCWVAGTIVGFLPLFGWHA
DVNHNQECLFVEVMDYNYLVFLYFATIITPALLMLAFYTHIYRVIIKQVRQIVTMNPASD
LSRRSSAAVVQVTTPGRGGHTGTMLRVLGAARKRDVKATQNLSIIVLFFMICWIPLYTIN
CIKAFCPDCYVHPKLTLFCIILSHLNSAVNPVLYAYHLKDFRAALKNLLLKMMGVDIDQQ
AEAIHRFSVASQHRLQSMDSNMRSTQPRLYVGEYSPIWLRQQQEALKNSQLLPKCGVVSP
CFNNINQTVAAVASVTTDLEREMWNIVEASSGAELGETSYEFPSPAPGSQRSSERNSSST
VPPAPPAPAKPSVPSASYDNHNYSFSQDEDEDDDDLEFEDVFVPASSVPNPVQPGIDPVE
LRRSLALVMREKLRSDDTDSRPMGNNQDLPIDEQSRERPLSTQTSPTNGPLPALLRAKLL
AGNSNSAHCLPGSTASPAPQEQSGIFVIDSEASPGSNGHKPKYRKGTAFTRSSLKKSRSC
NCSSIAKGRGVHDEPSSNLCRDQESSVLPQHPQPANHPTENFFSPLRSVGSFMQHSNLFH
FLQPHAARPTSSTASSTASTPTPSPPPMGQAQEESVPVGLTTSSPSLLATSAES

>Apis mellifera_(XP_394893)
MEFPSNISELANNLTVTALNASTHSELNLPYTVCEILVAVCAVFGNGLVIIVFSKEKKLRRRTNYYIISL
ATADLLVGLFAIPFAILASIGLPKNLHACLFTVSVLIVLCTISIFCLVAVSVDRYWAILHPMGYSRTVRT
KTAIGIICVCWIAGTLVGFLPLLGWNAGKKSNEKCIFTEVMDYDYLVFLYFATIIFPALLIAAFYAHIYR
VVVKQLQQIVTMNPGRRTGNQTTGTMLRLLGAARKREVKATQNLSRIVIFFIICWIPLYTINCVMAFCPW
CRVNDVVMNFCIILSHLNSAGNPLLYAYHLKDFRAALKNFMWNLLFPHNNMKSSVVSVIHERGSLVDSQR
QYHRQIGGLSSSKRPTSSLLRQVTDVRSKGLSVSRDISIRDKETGNASSSSQSDKQEDDNMSQNSNEFQR
NESDKFENNRIDSNISKSSSHITSMELQTYKPLMPLLPAEIDNVEETPPASIFVIEVDVNHMESVHKKVN
EELTENKDKG

>Anopheles gambiae_(XP_310647)
MTATGLLAGNATDECLRANGTPGWGNGTGDEPPEATVRLNLPYALLEATVALMAIFGNTLVIVAFRTERR
LRRRTNYYIVSLASADLLVGTLGIPFAVLASIGLPRNLHACLFTISLLVVLCTISIFCLVAVSIDRYWAI
LHPLAYSRNMRTKTTLYIISMCWLAGFIVGFLPLFGWHEQPAEDACLFVKVMNYDYLVFLYLVTIIIPAV
LLLAFYIHIYRVIVRQRKQILSVNSIDSRCMASIEDGTGSCSQSGRHATKRRTQRKDQYSGTMLRVLRAA
QNREVKATQNLSIIVLFFMLCWMPLHTINCIVAFCPQCHIHAPVMLLVITLSHLNSALNPLLYAYHLKDF
RAALKRLLLSLFGIAPRPAPPRDCVNCISALAQQHQQQQIFP

>Hydra magnipapillata_(XP_012556376)
MIVVHIHKIINTSSEIKKEEESKGRNTSKLNVYSVIAFCEIGCDYNIINRNAVYFFITTDVLFGITSILS
LTAISLERMFAVKFPTRHFNLSSALVFIVIAFTWFIGIVFSVAQFFISFQNVRWYIAFLLVFAYIFPLFI
IVVSYCIIYCAIRMMRDNSNQDGKTKQELRVAKIISIIIGLFFICWSPFFILNTVHLFCKEVYCRKLPIW
LINITKMLHYSHSMMNFFVYGYRSPDFRHIFRAFLKCRLSLMQGRVRSLSESINLEQSSSFKRERNIENS
EEVLVTLASDEI